POTENTIAL TARGETS FROM HUMAN (RESULTS FROM SUB-STRUCTURAL SIMILARITY SEARCHES)
1) User may click on the DrReposER ID (the second column) to get information on the binding sites and drug molecule.
2) Click View (the second last column) to view matched residues and superposition in the NGL viewer (upper right part).
3) User may also click on the Dock (the last column) to get script for molecular docking in UCSF Chimera through AutoDock Vina.

DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3G8I_A_RO7A1_1
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR ALPHA)		1jxk ALPHA-AMYLASE,
SALIVARY
(Homo
sapiens)		5 / 12VAL A 234
TYR A  67
ILE A 230
VAL A 175
TYR A 131
None
None
PCA  A   1 ( 4.5A)
None
None
1.25A18.86
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3G8I_A_RO7A1_1
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR ALPHA)		2p54 PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR ALPHA
(Homo
sapiens)		10 / 12CYH A 275
CYH A 276
SER A 280
TYR A 314
MET A 330
ILE A 339
ILE A 354
HIS A 440
VAL A 444
TYR A 464
735  A 469 ( 4.0A)
735  A 469 (-2.9A)
735  A 469 (-2.8A)
735  A 469 (-3.9A)
735  A 469 ( 3.2A)
735  A 469 ( 4.1A)
735  A 469 (-3.7A)
735  A 469 (-4.0A)
735  A 469 ( 3.9A)
735  A 469 (-4.6A)
0.67A100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3G8I_A_RO7A1_1
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR ALPHA)		2p54 PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR ALPHA
(Homo
sapiens)		10 / 12CYH A 275
CYH A 276
TYR A 314
MET A 330
ILE A 339
ILE A 354
MET A 355
HIS A 440
VAL A 444
TYR A 464
735  A 469 ( 4.0A)
735  A 469 (-2.9A)
735  A 469 (-3.9A)
735  A 469 ( 3.2A)
735  A 469 ( 4.1A)
735  A 469 (-3.7A)
735  A 469 (-2.9A)
735  A 469 (-4.0A)
735  A 469 ( 3.9A)
735  A 469 (-4.6A)
0.87A100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3G8I_A_RO7A1_1
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR ALPHA)		2p54 PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR ALPHA
(Homo
sapiens)		7 / 12SER A 280
TYR A 314
MET A 325
ILE A 354
HIS A 440
VAL A 444
TYR A 464
735  A 469 (-2.8A)
735  A 469 (-3.9A)
None
735  A 469 (-3.7A)
735  A 469 (-4.0A)
735  A 469 ( 3.9A)
735  A 469 (-4.6A)
1.24A100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3G8I_A_RO7A1_1
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR ALPHA)		2p54 PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR ALPHA
(Homo
sapiens)		7 / 12TYR A 314
MET A 325
ILE A 354
MET A 355
HIS A 440
VAL A 444
TYR A 464
735  A 469 (-3.9A)
None
735  A 469 (-3.7A)
735  A 469 (-2.9A)
735  A 469 (-4.0A)
735  A 469 ( 3.9A)
735  A 469 (-4.6A)
1.11A100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3G8I_A_RO7A1_1
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR ALPHA)		2p54 PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR ALPHA
(Homo
sapiens)		5 / 12VAL A 255
CYH A 275
CYH A 276
ILE A 354
TYR A 314
735  A 469 (-4.0A)
735  A 469 ( 4.0A)
735  A 469 (-2.9A)
735  A 469 (-3.7A)
735  A 469 (-3.9A)
1.33A100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3G8I_A_RO7A1_1
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR ALPHA)		2p54 PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR ALPHA
(Homo
sapiens)		10 / 12VAL A 255
CYH A 275
CYH A 276
SER A 280
TYR A 314
MET A 330
ILE A 339
ILE A 354
VAL A 444
TYR A 464
735  A 469 (-4.0A)
735  A 469 ( 4.0A)
735  A 469 (-2.9A)
735  A 469 (-2.8A)
735  A 469 (-3.9A)
735  A 469 ( 3.2A)
735  A 469 ( 4.1A)
735  A 469 (-3.7A)
735  A 469 ( 3.9A)
735  A 469 (-4.6A)
0.78A100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3G8I_A_RO7A1_1
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR ALPHA)		3b0q PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA
(Homo
sapiens)		5 / 12CYH A 285
SER A 289
MET A 364
HIS A 449
TYR A 473
MC5  A   1 (-3.6A)
MC5  A   1 (-2.6A)
MC5  A   1 (-3.7A)
MC5  A   1 (-3.9A)
MC5  A   1 (-4.9A)
0.92A61.85
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3G8I_A_RO7A1_1
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR ALPHA)		3b0q PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA
(Homo
sapiens)		5 / 12SER A 289
MET A 334
MET A 364
HIS A 449
TYR A 473
MC5  A   1 (-2.6A)
None
MC5  A   1 (-3.7A)
MC5  A   1 (-3.9A)
MC5  A   1 (-4.9A)
1.27A61.85
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3G8I_A_RO7A1_1
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR ALPHA)		3dzu PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA
(Homo
sapiens)		5 / 12SER D 289
MET D 334
MET D 364
HIS D 449
TYR D 473
PLB  D 701 ( 3.9A)
None
PLB  D 701 ( 4.8A)
None
None
1.33A61.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3G8I_A_RO7A1_1
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR ALPHA)		3ojy COMPLEMENT COMPONENT
C8 ALPHA CHAIN
COMPLEMENT COMPONENT
C8 BETA CHAIN
(Homo
sapiens)		5 / 12VAL B 473
ILE A 195
ILE B 381
VAL B 373
TYR B 300
None
1.28A18.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3G8I_A_RO7A1_1
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR ALPHA)		3q6m HEAT SHOCK PROTEIN
HSP 90-ALPHA
(Homo
sapiens)		5 / 12VAL A 600
CYH A 598
CYH A 597
MET A 575
ILE A 642
None
1.48A22.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3G8I_A_RO7A1_1
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR ALPHA)		3uo7 G/T
MISMATCH-SPECIFIC
THYMINE DNA
GLYCOSYLASE
(Homo
sapiens)		5 / 12VAL A 247
ILE A 237
ILE A 137
MET A 192
VAL A 135
None
1.42A20.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3G8I_A_RO7A1_1
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR ALPHA)		4elj RETINOBLASTOMA-ASSOC
IATED PROTEIN
(Homo
sapiens)		5 / 12VAL A 288
CYH A 221
ILE A 297
VAL A 190
TYR A 173
None
1.45A17.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3G8I_A_RO7A1_1
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR ALPHA)		4qae NEUTROPHIL
GELATINASE-ASSOCIATE
D LIPOCALIN
(Homo
sapiens)		5 / 12MET A  49
ILE A  68
MET A  70
VAL A  66
TYR A  56
None
1.27A18.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3G8I_A_RO7A1_1
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR ALPHA)		4qae NEUTROPHIL
GELATINASE-ASSOCIATE
D LIPOCALIN
(Homo
sapiens)		5 / 12TYR A 138
ILE A  68
MET A  70
VAL A  66
TYR A  56
None
1.25A18.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3G8I_A_RO7A1_2
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR ALPHA)		1fch PEROXISOMAL
TARGETING SIGNAL 1
RECEPTOR
(Homo
sapiens)		4 / 7LEU A 487
GLN A 366
LEU A 355
VAL A 374
None
0.84A21.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3G8I_A_RO7A1_2
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR ALPHA)		1zbu 3'-5' EXONUCLEASE
ERI1
(Homo
sapiens)		4 / 7LEU A 239
GLN A 343
VAL A 210
LEU A 227
None
0.83A21.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3G8I_A_RO7A1_2
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR ALPHA)		2c0l PEROXISOMAL
TARGETING SIGNAL 1
RECEPTOR
(Homo
sapiens)		4 / 7LEU A 524
GLN A 403
LEU A 392
VAL A 411
None
0.82A22.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3G8I_A_RO7A1_2
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR ALPHA)		2dlz PROTEIN VAV-2
(Homo
sapiens)		4 / 7LEU A  31
LEU A 104
VAL A  62
LEU A  88
None
0.94A19.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3G8I_A_RO7A1_2
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR ALPHA)		2dm0 TYROSINE-PROTEIN
KINASE TXK
(Homo
sapiens)		4 / 7LEU A  95
LEU A  32
VAL A  43
LEU A 110
None
0.67A14.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3G8I_A_RO7A1_2
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR ALPHA)		2ekx CYTOPLASMIC
TYROSINE-PROTEIN
KINASE BMX
(Homo
sapiens)		4 / 7LEU A  90
LEU A  27
VAL A  38
LEU A 105
None
0.78A16.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3G8I_A_RO7A1_2
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR ALPHA)		2gr9 PYRROLINE-5-CARBOXYL
ATE REDUCTASE 1
(Homo
sapiens)		4 / 7LEU A 153
VAL A   3
LEU A 148
LEU A 108
None
0.80A22.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3G8I_A_RO7A1_2
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR ALPHA)		2je1 ACIDIC LEUCINE-RICH
NUCLEAR
PHOSPHOPROTEIN 32
FAMILY MEMBER A
(Homo
sapiens)		4 / 7LEU A  34
LEU A 112
VAL A  82
LEU A 120
None
0.91A22.83
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3G8I_A_RO7A1_2
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR ALPHA)		2p54 PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR ALPHA
(Homo
sapiens)		7 / 7LEU A 247
GLN A 277
LEU A 321
VAL A 332
LEU A 344
LYS A 358
LEU A 460
None
735  A 469 (-4.4A)
735  A 469 ( 4.3A)
735  A 469 (-3.8A)
735  A 469 ( 4.2A)
None
735  A 469 (-4.3A)
0.64A100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3G8I_A_RO7A1_2
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR ALPHA)		2pid TYROSYL-TRNA
SYNTHETASE
(Homo
sapiens)		4 / 7GLN A 225
LEU A  98
VAL A 170
LEU A  87
YSA  A 384 (-3.3A)
None
None
None
0.86A22.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3G8I_A_RO7A1_2
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR ALPHA)		2vif SUPPRESSOR OF
CYTOKINE SIGNALLING
6
(Homo
sapiens)		4 / 7LEU A 457
LEU A 398
VAL A 408
LEU A 487
None
0.94A18.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3G8I_A_RO7A1_2
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR ALPHA)		2yd0 ENDOPLASMIC
RETICULUM
AMINOPEPTIDASE 1
(Homo
sapiens)		4 / 7GLN A 851
LEU A 860
VAL A 875
LEU A 898
None
0.95A15.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3G8I_A_RO7A1_2
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR ALPHA)		2zgh GRANZYME M
(Homo
sapiens)		4 / 7LEU A 107
GLN A  91
LEU A  54
VAL A  29
None
0.74A22.14
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3G8I_A_RO7A1_2
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR ALPHA)		3b0q PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA
(Homo
sapiens)		5 / 7GLN A 286
LEU A 330
LEU A 353
LYS A 367
LEU A 469
None
MC5  A   1 (-4.4A)
MC5  A   1 (-4.7A)
None
MC5  A   1 (-4.1A)
0.72A61.85
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3G8I_A_RO7A1_2
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR ALPHA)		3b0q PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA
(Homo
sapiens)		5 / 7LEU A 255
GLN A 286
LEU A 330
LEU A 353
LYS A 367
None
None
MC5  A   1 (-4.4A)
MC5  A   1 (-4.7A)
None
0.92A61.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3G8I_A_RO7A1_2
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR ALPHA)		3b97 ALPHA-ENOLASE
(Homo
sapiens)		4 / 7LEU A 170
LEU A 162
LEU A 226
LEU A 275
None
0.89A24.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3G8I_A_RO7A1_2
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR ALPHA)		3cuq VACUOLAR
PROTEIN-SORTING-ASSO
CIATED PROTEIN 36
VACUOLAR-SORTING
PROTEIN SNF8
(Homo
sapiens)		4 / 7LEU B 249
LEU B 352
LEU B 257
LEU A 109
None
0.91A24.91
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3G8I_A_RO7A1_2
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR ALPHA)		3d5f PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR DELTA
(Homo
sapiens)		4 / 7GLN A 286
LEU A 330
VAL A 341
LYS A 367
None
L41  A 501 (-4.9A)
L41  A 501 ( 4.4A)
None
0.88A70.41
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3G8I_A_RO7A1_2
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR ALPHA)		3d5f PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR DELTA
(Homo
sapiens)		4 / 7GLN A 286
VAL A 341
LYS A 367
LEU A 469
None
L41  A 501 ( 4.4A)
None
L41  A 501 (-3.8A)
0.56A70.41
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3G8I_A_RO7A1_2
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR ALPHA)		3d5f PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR DELTA
(Homo
sapiens)		5 / 7LEU A 255
GLN A 286
LEU A 330
VAL A 341
LEU A 353
None
None
L41  A 501 (-4.9A)
L41  A 501 ( 4.4A)
None
0.70A70.41
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3G8I_A_RO7A1_2
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR ALPHA)		3d5f PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR DELTA
(Homo
sapiens)		5 / 7LEU A 255
GLN A 286
VAL A 341
LEU A 353
LEU A 469
None
None
L41  A 501 ( 4.4A)
None
L41  A 501 (-3.8A)
0.60A70.41
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3G8I_A_RO7A1_2
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR ALPHA)		3dzu PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA
(Homo
sapiens)		5 / 7LEU D 255
GLN D 286
LEU D 330
LEU D 353
LEU D 469
None
None
PLB  D 701 ( 4.1A)
None
None
0.72A61.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3G8I_A_RO7A1_2
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR ALPHA)		4keg MALTOSE-BINDING
PERIPLASMIC/PALATE
LUNG AND NASAL
EPITHELIUM CLONE
FUSION PROTEIN
(Escherichia
coli;
Homo
sapiens)		4 / 7LEU A 290
LEU A  43
LEU A  20
LEU A  76
None
0.92A19.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3G8I_A_RO7A1_2
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR ALPHA)		4x4w CCA TRNA
NUCLEOTIDYLTRANSFERA
SE 1, MITOCHONDRIAL
(Homo
sapiens)		4 / 7LEU A 273
VAL A 225
LEU A 216
LEU A 194
None
0.84A21.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3G8I_A_RO7A1_2
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR ALPHA)		4x90 GROUP XV
PHOSPHOLIPASE A2
(Homo
sapiens)		4 / 7LEU A 144
LEU A 376
VAL A 159
LEU A 298
None
0.76A20.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3G8I_A_RO7A1_2
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR ALPHA)		5ho4 HETEROGENEOUS
NUCLEAR
RIBONUCLEOPROTEINS
A2/B1
(Homo
sapiens)		4 / 7LEU A 171
LEU A  47
VAL A  75
LEU A  28
None
0.90A21.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3G8I_A_RO7A1_2
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR ALPHA)		5sxg DNA DC->DU-EDITING
ENZYME APOBEC-3B
(Homo
sapiens)		4 / 7LEU A 259
VAL A 275
LEU A 216
LEU A 377
None
0.94A13.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3G8I_A_RO7A1_2
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR ALPHA)		5w2m DNA DC->DU-EDITING
ENZYME APOBEC-3F
(Homo
sapiens)		4 / 7LEU A 255
VAL A 271
LEU A 218
LEU A 372
None
0.62A11.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3G8I_A_RO7A1_2
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR ALPHA)		6b9x HEPATITIS B VIRUS X
INTERACTING PROTEIN
RAGULATOR COMPLEX
PROTEIN LAMTOR4
(Homo
sapiens)		4 / 7LEU E 119
GLN E 159
LEU D  46
VAL E 126
None
0.91A20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3G8I_A_RO7A1_2
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR ALPHA)		6f7p SERRATE RNA EFFECTOR
MOLECULE HOMOLOG
(Homo
sapiens)		4 / 7LEU A 227
VAL A 254
LEU A 268
LEU A 238
None
0.76A16.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3G8I_A_RO7A1_2
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR ALPHA)		6f8d SERRATE RNA EFFECTOR
MOLECULE HOMOLOG
(Homo
sapiens)		4 / 7LEU A 227
VAL A 254
LEU A 268
LEU A 238
None
0.75A15.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3G9E_A_RO7A1_1
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		1ezf FARNESYL-DIPHOSPHATE
FARNESYLTRANSFERASE
(Homo
sapiens)		5 / 12LEU A 186
VAL A 142
ILE A 146
LEU A  47
TYR A  44
None
1.28A22.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3G9E_A_RO7A1_1
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		2d7t ANTI
POLYHYDROXYBUTYRATE
ANTIBODY FV, HEAVY
CHAIN
ANTI
POLYHYDROXYBUTYRATE
ANTIBODY FV, LIGHT
CHAIN
(Homo
sapiens)		5 / 12GLY H  49
VAL H  79
ILE H  51
LEU L  89
TYR L  36
None
1.22A18.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3G9E_A_RO7A1_1
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		2he3 GLUTATHIONE
PEROXIDASE 2
(Homo
sapiens)		5 / 12LEU A  64
VAL A  21
ILE A  14
LEU A  86
TYR A  95
None
1.13A22.92
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3G9E_A_RO7A1_1
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		2p54 PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR ALPHA
(Homo
sapiens)		7 / 12CYH A 276
LEU A 321
ILE A 339
LYS A 358
HIS A 440
LEU A 460
TYR A 464
735  A 469 (-2.9A)
735  A 469 ( 4.3A)
735  A 469 ( 4.1A)
None
735  A 469 (-4.0A)
735  A 469 (-4.3A)
735  A 469 (-4.6A)
1.39A61.94
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3G9E_A_RO7A1_1
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		2p54 PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR ALPHA
(Homo
sapiens)		6 / 12CYH A 276
SER A 280
LYS A 358
HIS A 440
LEU A 460
TYR A 464
735  A 469 (-2.9A)
735  A 469 (-2.8A)
None
735  A 469 (-4.0A)
735  A 469 (-4.3A)
735  A 469 (-4.6A)
0.86A61.94
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3G9E_A_RO7A1_1
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		3b0q PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA
(Homo
sapiens)		12 / 12GLY A 284
CYH A 285
SER A 289
HIS A 323
TYR A 327
LEU A 330
VAL A 339
ILE A 341
LYS A 367
HIS A 449
LEU A 469
TYR A 473
MC5  A   1 ( 4.5A)
MC5  A   1 (-3.6A)
MC5  A   1 (-2.6A)
MC5  A   1 (-3.8A)
None
MC5  A   1 (-4.4A)
MC5  A   1 (-4.6A)
MC5  A   1 (-4.5A)
None
MC5  A   1 (-3.9A)
MC5  A   1 (-4.1A)
MC5  A   1 (-4.9A)
0.54A100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3G9E_A_RO7A1_1
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		3d34 SPONDIN-2
(Homo
sapiens)		5 / 12GLY A  48
LEU A 158
VAL A 213
ILE A  19
LEU A  68
None
1.26A24.57
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3G9E_A_RO7A1_1
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		3d5f PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR DELTA
(Homo
sapiens)		7 / 12CYH A 285
HIS A 323
LEU A 330
LYS A 367
HIS A 449
LEU A 469
TYR A 473
L41  A 501 (-3.5A)
L41  A 501 (-3.8A)
L41  A 501 (-4.9A)
None
L41  A 501 (-3.9A)
L41  A 501 (-3.8A)
L41  A 501 (-4.8A)
0.65A62.92
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3G9E_A_RO7A1_1
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		3d5f PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR DELTA
(Homo
sapiens)		6 / 12HIS A 323
LEU A 330
VAL A 334
LYS A 367
HIS A 449
TYR A 473
L41  A 501 (-3.8A)
L41  A 501 (-4.9A)
None
None
L41  A 501 (-3.9A)
L41  A 501 (-4.8A)
1.39A62.92
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3G9E_A_RO7A1_1
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		3dzu PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA
(Homo
sapiens)		5 / 12CYH D 285
TYR D 327
LEU D 330
VAL D 339
HIS D 449
PLB  D 701 (-3.2A)
None
PLB  D 701 ( 4.1A)
None
None
0.91A100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3G9E_A_RO7A1_1
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		3dzu PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA
(Homo
sapiens)		5 / 12GLY D 284
CYH D 285
LEU D 330
VAL D 339
HIS D 449
PLB  D 701 (-3.3A)
PLB  D 701 (-3.2A)
PLB  D 701 ( 4.1A)
None
None
0.93A100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3G9E_A_RO7A1_1
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		3dzu PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA
(Homo
sapiens)		7 / 12GLY D 284
LEU D 330
VAL D 339
ILE D 341
HIS D 449
LEU D 469
TYR D 473
PLB  D 701 (-3.3A)
PLB  D 701 ( 4.1A)
None
PLB  D 701 (-3.6A)
None
None
None
0.68A100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3G9E_A_RO7A1_1
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		3dzu PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA
(Homo
sapiens)		6 / 12GLY D 284
SER D 289
ILE D 341
HIS D 449
LEU D 469
TYR D 473
PLB  D 701 (-3.3A)
PLB  D 701 ( 3.9A)
PLB  D 701 (-3.6A)
None
None
None
0.91A100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3G9E_A_RO7A1_1
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		3dzu PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA
(Homo
sapiens)		5 / 12HIS D 323
TYR D 327
HIS D 449
LEU D 469
TYR D 473
None
1.19A100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3G9E_A_RO7A1_1
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		3dzu PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA
(Homo
sapiens)		6 / 12SER D 289
TYR D 327
ILE D 341
HIS D 449
LEU D 469
TYR D 473
PLB  D 701 ( 3.9A)
None
PLB  D 701 (-3.6A)
None
None
None
1.00A100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3G9E_A_RO7A1_1
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		3dzu PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA
(Homo
sapiens)		7 / 12TYR D 327
LEU D 330
VAL D 339
ILE D 341
HIS D 449
LEU D 469
TYR D 473
None
PLB  D 701 ( 4.1A)
None
PLB  D 701 (-3.6A)
None
None
None
0.80A100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3G9E_A_RO7A1_1
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		3gqc DNA REPAIR PROTEIN
REV1
(Homo
sapiens)		5 / 12GLY A 797
LEU A 743
VAL A 821
ILE A 819
LYS A 749
None
1.21A21.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3G9E_A_RO7A1_1
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		3j0a TOLL-LIKE RECEPTOR 5
(Homo
sapiens)		5 / 12GLY A 270
LEU A 303
VAL A 300
ILE A 264
LYS A 326
None
1.27A16.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3G9E_A_RO7A1_1
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		4d86 POLY [ADP-RIBOSE]
POLYMERASE 14
(Homo
sapiens)		5 / 12SER A 823
HIS A 829
LEU A 833
ILE A 918
LEU A 827
None
None
ADP  A1201 (-3.9A)
None
None
1.26A21.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3G9E_A_RO7A1_1
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		4fod ALK TYROSINE KINASE
RECEPTOR
(Homo
sapiens)		5 / 12GLY A1326
SER A1206
LEU A1257
VAL A1229
ILE A1322
None
1.21A22.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3G9E_A_RO7A1_1
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		5ddb MENIN
(Homo
sapiens)		5 / 12GLY A 163
CYH A 165
LEU A 103
VAL A 101
ILE A  97
None
1.09A20.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3G9E_A_RO7A1_1
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		5exr DNA POLYMERASE ALPHA
SUBUNIT B
(Homo
sapiens)		5 / 12GLY D 255
LEU D 296
VAL D 270
LEU D 231
TYR D 235
None
1.16A19.83