POTENTIAL TARGETS FROM HUMAN (RESULTS FROM SUB-STRUCTURAL SIMILARITY SEARCHES)
1) User may click on the DrReposER ID (the second column) to get information on the binding sites and drug molecule.
2) Click View (the second last column) to view matched residues and superposition in the NGL viewer (upper right part).
3) User may also click on the Dock (the last column) to get script for molecular docking in UCSF Chimera through AutoDock Vina.

DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RQJ_A_RISA901_1
(GERANYLTRANSTRANSFER
ASE)		2q80 GERANYLGERANYL
PYROPHOSPHATE
SYNTHETASE
(Homo
sapiens)		5 / 11ASP A  64
ASP A  68
GLN A 126
LYS A 151
THR A 152
GRG  A 500 (-2.4A)
MG  A 400 (-2.6A)
GRG  A 500 ( 3.5A)
GRG  A 500 (-2.8A)
GRG  A 500 ( 4.6A)
0.82A25.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RQJ_A_RISA901_1
(GERANYLTRANSTRANSFER
ASE)		2q80 GERANYLGERANYL
PYROPHOSPHATE
SYNTHETASE
(Homo
sapiens)		7 / 11SER A  60
LEU A  61
ARG A  73
GLN A 126
LYS A 151
GLN A 185
LYS A 202
GRG  A 500 ( 4.2A)
None
GRG  A 500 (-2.9A)
GRG  A 500 ( 3.5A)
GRG  A 500 (-2.8A)
GRG  A 500 (-3.2A)
GRG  A 500 ( 2.6A)
1.26A25.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RQJ_A_RISA901_1
(GERANYLTRANSTRANSFER
ASE)		2q80 GERANYLGERANYL
PYROPHOSPHATE
SYNTHETASE
(Homo
sapiens)		9 / 11SER A  60
LEU A  61
ASP A  64
ASP A  68
ARG A  73
GLN A 126
LYS A 151
GLN A 185
ASP A 188
GRG  A 500 ( 4.2A)
None
GRG  A 500 (-2.4A)
MG  A 400 (-2.6A)
GRG  A 500 (-2.9A)
GRG  A 500 ( 3.5A)
GRG  A 500 (-2.8A)
GRG  A 500 (-3.2A)
GRG  A 500 (-3.5A)
0.71A25.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RQJ_A_RISA901_1
(GERANYLTRANSTRANSFER
ASE)		4p0v FARNESYL
PYROPHOSPHATE
SYNTHASE
(Homo
sapiens)		10 / 11LEU A 100
ASP A 103
ASP A 107
ARG A 112
GLN A 171
LYS A 200
THR A 201
GLN A 240
ASP A 243
LYS A 257
None
MG  A 405 (-2.5A)
MG  A 405 (-2.4A)
ZOL  A 401 ( 2.7A)
ZOL  A 401 ( 3.8A)
ZOL  A 401 (-2.7A)
ZOL  A 401 (-3.7A)
ZOL  A 401 (-3.5A)
MG  A 404 (-2.8A)
1WO  A 402 ( 2.8A)
0.33A27.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RQJ_B_RISB903_1
(GERANYLTRANSTRANSFER
ASE)		2q80 GERANYLGERANYL
PYROPHOSPHATE
SYNTHETASE
(Homo
sapiens)		7 / 11LEU A  61
ASP A  64
ASP A  68
ARG A  73
GLN A 126
LYS A 151
THR A 152
None
GRG  A 500 (-2.4A)
MG  A 400 (-2.6A)
GRG  A 500 (-2.9A)
GRG  A 500 ( 3.5A)
GRG  A 500 (-2.8A)
GRG  A 500 ( 4.6A)
0.74A25.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RQJ_B_RISB903_1
(GERANYLTRANSTRANSFER
ASE)		2q80 GERANYLGERANYL
PYROPHOSPHATE
SYNTHETASE
(Homo
sapiens)		7 / 11SER A  60
LEU A  61
ARG A  73
GLN A 126
LYS A 151
GLN A 185
LYS A 202
GRG  A 500 ( 4.2A)
None
GRG  A 500 (-2.9A)
GRG  A 500 ( 3.5A)
GRG  A 500 (-2.8A)
GRG  A 500 (-3.2A)
GRG  A 500 ( 2.6A)
1.24A25.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RQJ_B_RISB903_1
(GERANYLTRANSTRANSFER
ASE)		2q80 GERANYLGERANYL
PYROPHOSPHATE
SYNTHETASE
(Homo
sapiens)		9 / 11SER A  60
LEU A  61
ASP A  64
ASP A  68
ARG A  73
GLN A 126
LYS A 151
GLN A 185
ASP A 188
GRG  A 500 ( 4.2A)
None
GRG  A 500 (-2.4A)
MG  A 400 (-2.6A)
GRG  A 500 (-2.9A)
GRG  A 500 ( 3.5A)
GRG  A 500 (-2.8A)
GRG  A 500 (-3.2A)
GRG  A 500 (-3.5A)
0.71A25.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RQJ_B_RISB903_1
(GERANYLTRANSTRANSFER
ASE)		4p0v FARNESYL
PYROPHOSPHATE
SYNTHASE
(Homo
sapiens)		10 / 11LEU A 100
ASP A 103
ASP A 107
ARG A 112
GLN A 171
LYS A 200
THR A 201
GLN A 240
ASP A 243
LYS A 257
None
MG  A 405 (-2.5A)
MG  A 405 (-2.4A)
ZOL  A 401 ( 2.7A)
ZOL  A 401 ( 3.8A)
ZOL  A 401 (-2.7A)
ZOL  A 401 (-3.7A)
ZOL  A 401 (-3.5A)
MG  A 404 (-2.8A)
1WO  A 402 ( 2.8A)
0.34A27.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YHL_A_RISA1400_1
(FARNESYL
PYROPHOSPHATE
SYNTHASE)		2q80 GERANYLGERANYL
PYROPHOSPHATE
SYNTHETASE
(Homo
sapiens)		6 / 11LEU A  61
ARG A  73
GLN A 126
LYS A 151
GLN A 185
LYS A 202
None
GRG  A 500 (-2.9A)
GRG  A 500 ( 3.5A)
GRG  A 500 (-2.8A)
GRG  A 500 (-3.2A)
GRG  A 500 ( 2.6A)
1.27A25.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YHL_A_RISA1400_1
(FARNESYL
PYROPHOSPHATE
SYNTHASE)		2q80 GERANYLGERANYL
PYROPHOSPHATE
SYNTHETASE
(Homo
sapiens)		8 / 11LEU A  61
ASP A  64
ASP A  68
ARG A  73
GLN A 126
LYS A 151
GLN A 185
ASP A 188
None
GRG  A 500 (-2.4A)
MG  A 400 (-2.6A)
GRG  A 500 (-2.9A)
GRG  A 500 ( 3.5A)
GRG  A 500 (-2.8A)
GRG  A 500 (-3.2A)
GRG  A 500 (-3.5A)
0.62A25.54
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1YHL_A_RISA1400_1
(FARNESYL
PYROPHOSPHATE
SYNTHASE)		4p0v FARNESYL
PYROPHOSPHATE
SYNTHASE
(Homo
sapiens)		11 / 11LEU A 100
ASP A 103
ASP A 107
ARG A 112
GLN A 171
LYS A 200
THR A 201
TYR A 204
GLN A 240
ASP A 243
LYS A 257
None
MG  A 405 (-2.5A)
MG  A 405 (-2.4A)
ZOL  A 401 ( 2.7A)
ZOL  A 401 ( 3.8A)
ZOL  A 401 (-2.7A)
ZOL  A 401 (-3.7A)
None
ZOL  A 401 (-3.5A)
MG  A 404 (-2.8A)
1WO  A 402 ( 2.8A)
0.30A37.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YQ7_A_RISA901_1
(FARNESYL
PYROPHOSPHATE
SYNTHETASE)		2q80 GERANYLGERANYL
PYROPHOSPHATE
SYNTHETASE
(Homo
sapiens)		6 / 11LEU A  61
ARG A  73
GLN A 126
LYS A 151
GLN A 185
LYS A 202
None
GRG  A 500 (-2.9A)
GRG  A 500 ( 3.5A)
GRG  A 500 (-2.8A)
GRG  A 500 (-3.2A)
GRG  A 500 ( 2.6A)
1.17A26.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YQ7_A_RISA901_1
(FARNESYL
PYROPHOSPHATE
SYNTHETASE)		2q80 GERANYLGERANYL
PYROPHOSPHATE
SYNTHETASE
(Homo
sapiens)		8 / 11LEU A  61
ASP A  64
ASP A  68
ARG A  73
GLN A 126
LYS A 151
GLN A 185
ASP A 188
None
GRG  A 500 (-2.4A)
MG  A 400 (-2.6A)
GRG  A 500 (-2.9A)
GRG  A 500 ( 3.5A)
GRG  A 500 (-2.8A)
GRG  A 500 (-3.2A)
GRG  A 500 (-3.5A)
0.71A26.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YQ7_A_RISA901_1
(FARNESYL
PYROPHOSPHATE
SYNTHETASE)		2q80 GERANYLGERANYL
PYROPHOSPHATE
SYNTHETASE
(Homo
sapiens)		7 / 11LEU A  61
ASP A  64
ASP A  68
ARG A  73
GLN A 126
LYS A 151
THR A 152
None
GRG  A 500 (-2.4A)
MG  A 400 (-2.6A)
GRG  A 500 (-2.9A)
GRG  A 500 ( 3.5A)
GRG  A 500 (-2.8A)
GRG  A 500 ( 4.6A)
0.79A26.90
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1YQ7_A_RISA901_1
(FARNESYL
PYROPHOSPHATE
SYNTHETASE)		4p0v FARNESYL
PYROPHOSPHATE
SYNTHASE
(Homo
sapiens)		11 / 11LEU A 100
ASP A 103
ASP A 107
ARG A 112
GLN A 171
LYS A 200
THR A 201
TYR A 204
GLN A 240
ASP A 243
LYS A 257
None
MG  A 405 (-2.5A)
MG  A 405 (-2.4A)
ZOL  A 401 ( 2.7A)
ZOL  A 401 ( 3.8A)
ZOL  A 401 (-2.7A)
ZOL  A 401 (-3.7A)
None
ZOL  A 401 (-3.5A)
MG  A 404 (-2.8A)
1WO  A 402 ( 2.8A)
0.34A100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YV5_A_RISA901_1
(FARNESYL
PYROPHOSPHATE
SYNTHETASE)		2q80 GERANYLGERANYL
PYROPHOSPHATE
SYNTHETASE
(Homo
sapiens)		6 / 10LEU A  61
ARG A  73
GLN A 126
LYS A 151
GLN A 185
LYS A 202
None
GRG  A 500 (-2.9A)
GRG  A 500 ( 3.5A)
GRG  A 500 (-2.8A)
GRG  A 500 (-3.2A)
GRG  A 500 ( 2.6A)
1.23A26.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YV5_A_RISA901_1
(FARNESYL
PYROPHOSPHATE
SYNTHETASE)		2q80 GERANYLGERANYL
PYROPHOSPHATE
SYNTHETASE
(Homo
sapiens)		8 / 10LEU A  61
ASP A  64
ASP A  68
ARG A  73
GLN A 126
LYS A 151
GLN A 185
ASP A 188
None
GRG  A 500 (-2.4A)
MG  A 400 (-2.6A)
GRG  A 500 (-2.9A)
GRG  A 500 ( 3.5A)
GRG  A 500 (-2.8A)
GRG  A 500 (-3.2A)
GRG  A 500 (-3.5A)
0.66A26.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YV5_A_RISA901_1
(FARNESYL
PYROPHOSPHATE
SYNTHETASE)		2q80 GERANYLGERANYL
PYROPHOSPHATE
SYNTHETASE
(Homo
sapiens)		5 / 10LEU A  61
ASP A  68
GLN A 126
LYS A 151
THR A 152
None
MG  A 400 (-2.6A)
GRG  A 500 ( 3.5A)
GRG  A 500 (-2.8A)
GRG  A 500 ( 4.6A)
0.80A26.90
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1YV5_A_RISA901_1
(FARNESYL
PYROPHOSPHATE
SYNTHETASE)		4p0v FARNESYL
PYROPHOSPHATE
SYNTHASE
(Homo
sapiens)		5 / 10ASP A 107
ARG A 112
GLN A 240
ASP A 243
LYS A 257
 MG  A 405 (-2.4A)
ZOL  A 401 ( 2.7A)
ZOL  A 401 (-3.5A)
MG  A 404 (-2.8A)
1WO  A 402 ( 2.8A)
1.20A100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1YV5_A_RISA901_1
(FARNESYL
PYROPHOSPHATE
SYNTHETASE)		4p0v FARNESYL
PYROPHOSPHATE
SYNTHASE
(Homo
sapiens)		10 / 10LEU A 100
ASP A 103
ASP A 107
ARG A 112
GLN A 171
LYS A 200
THR A 201
GLN A 240
ASP A 243
LYS A 257
None
MG  A 405 (-2.5A)
MG  A 405 (-2.4A)
ZOL  A 401 ( 2.7A)
ZOL  A 401 ( 3.8A)
ZOL  A 401 (-2.7A)
ZOL  A 401 (-3.7A)
ZOL  A 401 (-3.5A)
MG  A 404 (-2.8A)
1WO  A 402 ( 2.8A)
0.18A100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2O1O_A_RISA400_1
(PUTATIVE FARNESYL
PYROPHOSPHATE
SYNTHASE)		2q80 GERANYLGERANYL
PYROPHOSPHATE
SYNTHETASE
(Homo
sapiens)		6 / 9ASP A  68
ARG A  73
GLN A 126
LYS A 151
THR A 152
GLN A 185
 MG  A 400 (-2.6A)
GRG  A 500 (-2.9A)
GRG  A 500 ( 3.5A)
GRG  A 500 (-2.8A)
GRG  A 500 ( 4.6A)
GRG  A 500 (-3.2A)
0.80A23.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2O1O_A_RISA400_1
(PUTATIVE FARNESYL
PYROPHOSPHATE
SYNTHASE)		2q80 GERANYLGERANYL
PYROPHOSPHATE
SYNTHETASE
(Homo
sapiens)		7 / 9LEU A  61
ASP A  64
ASP A  68
ARG A  73
GLN A 126
LYS A 151
GLN A 185
None
GRG  A 500 (-2.4A)
MG  A 400 (-2.6A)
GRG  A 500 (-2.9A)
GRG  A 500 ( 3.5A)
GRG  A 500 (-2.8A)
GRG  A 500 (-3.2A)
0.51A23.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2O1O_A_RISA400_1
(PUTATIVE FARNESYL
PYROPHOSPHATE
SYNTHASE)		4p0v FARNESYL
PYROPHOSPHATE
SYNTHASE
(Homo
sapiens)		8 / 9LEU A 100
ASP A 103
ASP A 107
ARG A 112
GLN A 171
LYS A 200
THR A 201
GLN A 240
None
MG  A 405 (-2.5A)
MG  A 405 (-2.4A)
ZOL  A 401 ( 2.7A)
ZOL  A 401 ( 3.8A)
ZOL  A 401 (-2.7A)
ZOL  A 401 (-3.7A)
ZOL  A 401 (-3.5A)
0.40A29.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2O1O_B_RISB400_1
(PUTATIVE FARNESYL
PYROPHOSPHATE
SYNTHASE)		2q80 GERANYLGERANYL
PYROPHOSPHATE
SYNTHETASE
(Homo
sapiens)		8 / 10LEU A  61
ASP A  64
ASP A  68
ARG A  73
GLN A 126
LYS A 151
GLN A 185
LYS A 212
None
GRG  A 500 (-2.4A)
MG  A 400 (-2.6A)
GRG  A 500 (-2.9A)
GRG  A 500 ( 3.5A)
GRG  A 500 (-2.8A)
GRG  A 500 (-3.2A)
GRG  A 500 (-2.8A)
0.88A23.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2O1O_B_RISB400_1
(PUTATIVE FARNESYL
PYROPHOSPHATE
SYNTHASE)		4p0v FARNESYL
PYROPHOSPHATE
SYNTHASE
(Homo
sapiens)		8 / 10LEU A 100
ASP A 103
ASP A 107
ARG A 112
GLN A 171
LYS A 200
THR A 201
GLN A 240
None
MG  A 405 (-2.5A)
MG  A 405 (-2.4A)
ZOL  A 401 ( 2.7A)
ZOL  A 401 ( 3.8A)
ZOL  A 401 (-2.7A)
ZOL  A 401 (-3.7A)
ZOL  A 401 (-3.5A)
0.43A29.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2O1O_B_RISB400_1
(PUTATIVE FARNESYL
PYROPHOSPHATE
SYNTHASE)		4p0v FARNESYL
PYROPHOSPHATE
SYNTHASE
(Homo
sapiens)		6 / 10LEU A 100
ASP A 103
ASP A 107
GLN A 171
LYS A 200
LYS A 266
None
MG  A 405 (-2.5A)
MG  A 405 (-2.4A)
ZOL  A 401 ( 3.8A)
ZOL  A 401 (-2.7A)
MG  A 405 ( 4.4A)
1.20A29.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QIS_A_RISA901_1
(FARNESYL
PYROPHOSPHATE
SYNTHETASE)		2q80 GERANYLGERANYL
PYROPHOSPHATE
SYNTHETASE
(Homo
sapiens)		6 / 10LEU A  61
ARG A  73
GLN A 126
LYS A 151
GLN A 185
LYS A 202
None
GRG  A 500 (-2.9A)
GRG  A 500 ( 3.5A)
GRG  A 500 (-2.8A)
GRG  A 500 (-3.2A)
GRG  A 500 ( 2.6A)
1.27A26.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QIS_A_RISA901_1
(FARNESYL
PYROPHOSPHATE
SYNTHETASE)		2q80 GERANYLGERANYL
PYROPHOSPHATE
SYNTHETASE
(Homo
sapiens)		8 / 10LEU A  61
ASP A  64
ASP A  68
ARG A  73
GLN A 126
LYS A 151
GLN A 185
ASP A 188
None
GRG  A 500 (-2.4A)
MG  A 400 (-2.6A)
GRG  A 500 (-2.9A)
GRG  A 500 ( 3.5A)
GRG  A 500 (-2.8A)
GRG  A 500 (-3.2A)
GRG  A 500 (-3.5A)
0.63A26.63
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2QIS_A_RISA901_1
(FARNESYL
PYROPHOSPHATE
SYNTHETASE)		4p0v FARNESYL
PYROPHOSPHATE
SYNTHASE
(Homo
sapiens)		9 / 10LEU A 100
ASP A 103
ASP A 107
ARG A 112
GLN A 171
LYS A 200
GLN A 240
ASP A 243
LYS A 257
None
MG  A 405 (-2.5A)
MG  A 405 (-2.4A)
ZOL  A 401 ( 2.7A)
ZOL  A 401 ( 3.8A)
ZOL  A 401 (-2.7A)
ZOL  A 401 (-3.5A)
MG  A 404 (-2.8A)
1WO  A 402 ( 2.8A)
0.23A99.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KPD_A_RISA405_1
(FARNESYL
PYROPHOSPHATE
SYNTHASE)		2q80 GERANYLGERANYL
PYROPHOSPHATE
SYNTHETASE
(Homo
sapiens)		6 / 10LEU A  61
ARG A  73
GLN A 126
LYS A 151
GLN A 185
LYS A 202
None
GRG  A 500 (-2.9A)
GRG  A 500 ( 3.5A)
GRG  A 500 (-2.8A)
GRG  A 500 (-3.2A)
GRG  A 500 ( 2.6A)
1.28A26.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KPD_A_RISA405_1
(FARNESYL
PYROPHOSPHATE
SYNTHASE)		2q80 GERANYLGERANYL
PYROPHOSPHATE
SYNTHETASE
(Homo
sapiens)		8 / 10LEU A  61
ASP A  64
ASP A  68
ARG A  73
GLN A 126
LYS A 151
GLN A 185
ASP A 188
None
GRG  A 500 (-2.4A)
MG  A 400 (-2.6A)
GRG  A 500 (-2.9A)
GRG  A 500 ( 3.5A)
GRG  A 500 (-2.8A)
GRG  A 500 (-3.2A)
GRG  A 500 (-3.5A)
0.64A26.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KPD_A_RISA405_1
(FARNESYL
PYROPHOSPHATE
SYNTHASE)		2q80 GERANYLGERANYL
PYROPHOSPHATE
SYNTHETASE
(Homo
sapiens)		6 / 10LEU A  61
ASP A  64
ASP A  68
GLN A 126
LYS A 151
THR A 152
None
GRG  A 500 (-2.4A)
MG  A 400 (-2.6A)
GRG  A 500 ( 3.5A)
GRG  A 500 (-2.8A)
GRG  A 500 ( 4.6A)
0.75A26.90
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4KPD_A_RISA405_1
(FARNESYL
PYROPHOSPHATE
SYNTHASE)		4p0v FARNESYL
PYROPHOSPHATE
SYNTHASE
(Homo
sapiens)		10 / 10LEU A 100
ASP A 103
ASP A 107
ARG A 112
GLN A 171
LYS A 200
THR A 201
GLN A 240
ASP A 243
LYS A 257
None
MG  A 405 (-2.5A)
MG  A 405 (-2.4A)
ZOL  A 401 ( 2.7A)
ZOL  A 401 ( 3.8A)
ZOL  A 401 (-2.7A)
ZOL  A 401 (-3.7A)
ZOL  A 401 (-3.5A)
MG  A 404 (-2.8A)
1WO  A 402 ( 2.8A)
0.21A99.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KQS_A_RISA405_1
(FARNESYL
PYROPHOSPHATE
SYNTHASE)		2q80 GERANYLGERANYL
PYROPHOSPHATE
SYNTHETASE
(Homo
sapiens)		6 / 10LEU A  61
ARG A  73
GLN A 126
LYS A 151
GLN A 185
LYS A 202
None
GRG  A 500 (-2.9A)
GRG  A 500 ( 3.5A)
GRG  A 500 (-2.8A)
GRG  A 500 (-3.2A)
GRG  A 500 ( 2.6A)
1.28A26.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KQS_A_RISA405_1
(FARNESYL
PYROPHOSPHATE
SYNTHASE)		2q80 GERANYLGERANYL
PYROPHOSPHATE
SYNTHETASE
(Homo
sapiens)		8 / 10LEU A  61
ASP A  64
ASP A  68
ARG A  73
GLN A 126
LYS A 151
GLN A 185
ASP A 188
None
GRG  A 500 (-2.4A)
MG  A 400 (-2.6A)
GRG  A 500 (-2.9A)
GRG  A 500 ( 3.5A)
GRG  A 500 (-2.8A)
GRG  A 500 (-3.2A)
GRG  A 500 (-3.5A)
0.63A26.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KQS_A_RISA405_1
(FARNESYL
PYROPHOSPHATE
SYNTHASE)		2q80 GERANYLGERANYL
PYROPHOSPHATE
SYNTHETASE
(Homo
sapiens)		5 / 10LEU A  61
ASP A  68
GLN A 126
LYS A 151
THR A 152
None
MG  A 400 (-2.6A)
GRG  A 500 ( 3.5A)
GRG  A 500 (-2.8A)
GRG  A 500 ( 4.6A)
0.81A26.90
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4KQS_A_RISA405_1
(FARNESYL
PYROPHOSPHATE
SYNTHASE)		4p0v FARNESYL
PYROPHOSPHATE
SYNTHASE
(Homo
sapiens)		10 / 10LEU A 100
ASP A 103
ASP A 107
ARG A 112
GLN A 171
LYS A 200
THR A 201
GLN A 240
ASP A 243
LYS A 257
None
MG  A 405 (-2.5A)
MG  A 405 (-2.4A)
ZOL  A 401 ( 2.7A)
ZOL  A 401 ( 3.8A)
ZOL  A 401 (-2.7A)
ZOL  A 401 (-3.7A)
ZOL  A 401 (-3.5A)
MG  A 404 (-2.8A)
1WO  A 402 ( 2.8A)
0.22A99.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4N9U_A_RISA404_1
(FARNESYL
PYROPHOSPHATE
SYNTHASE)		2f1z UBIQUITIN
CARBOXYL-TERMINAL
HYDROLASE 7
(Homo
sapiens)		5 / 10LEU A 216
ASP A 482
ASP A 481
THR A 222
GLN A 219
None
1.49A21.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4N9U_A_RISA404_1
(FARNESYL
PYROPHOSPHATE
SYNTHASE)		2q80 GERANYLGERANYL
PYROPHOSPHATE
SYNTHETASE
(Homo
sapiens)		5 / 10LEU A  61
ARG A  73
GLN A 126
GLN A 185
LYS A 202
None
GRG  A 500 (-2.9A)
GRG  A 500 ( 3.5A)
GRG  A 500 (-3.2A)
GRG  A 500 ( 2.6A)
1.35A26.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4N9U_A_RISA404_1
(FARNESYL
PYROPHOSPHATE
SYNTHASE)		2q80 GERANYLGERANYL
PYROPHOSPHATE
SYNTHETASE
(Homo
sapiens)		7 / 10LEU A  61
ASP A  64
ASP A  68
ARG A  73
GLN A 126
GLN A 185
ASP A 188
None
GRG  A 500 (-2.4A)
MG  A 400 (-2.6A)
GRG  A 500 (-2.9A)
GRG  A 500 ( 3.5A)
GRG  A 500 (-3.2A)
GRG  A 500 (-3.5A)
0.56A26.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4N9U_A_RISA404_1
(FARNESYL
PYROPHOSPHATE
SYNTHASE)		2q80 GERANYLGERANYL
PYROPHOSPHATE
SYNTHETASE
(Homo
sapiens)		5 / 10LEU A  61
ASP A  64
ASP A  68
ARG A  73
THR A 152
None
GRG  A 500 (-2.4A)
MG  A 400 (-2.6A)
GRG  A 500 (-2.9A)
GRG  A 500 ( 4.6A)
1.33A26.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4N9U_A_RISA404_1
(FARNESYL
PYROPHOSPHATE
SYNTHASE)		2qqk NEUROPILIN-2
(Homo
sapiens)		5 / 10ASP A 301
THR A 298
THR A 305
GLN A 308
ASP A 315
None
1.40A18.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4N9U_A_RISA404_1
(FARNESYL
PYROPHOSPHATE
SYNTHASE)		2qqo NEUROPILIN-2
(Homo
sapiens)		5 / 10ASP A 301
THR A 298
THR A 305
GLN A 308
ASP A 315
None
1.44A19.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4N9U_A_RISA404_1
(FARNESYL
PYROPHOSPHATE
SYNTHASE)		3mop INTERLEUKIN-1
RECEPTOR-ASSOCIATED
KINASE 4
(Homo
sapiens)		5 / 10LEU G 100
ASP G 103
THR G   9
THR G  80
ASP G  86
None
1.36A14.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4N9U_A_RISA404_1
(FARNESYL
PYROPHOSPHATE
SYNTHASE)		4flc ADENYLOSUCCINATE
LYASE
(Homo
sapiens)		5 / 10LEU A 121
ASP A 117
THR A 239
THR A 244
ASP A 248
None
1.23A22.53
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4N9U_A_RISA404_1
(FARNESYL
PYROPHOSPHATE
SYNTHASE)		4p0v FARNESYL
PYROPHOSPHATE
SYNTHASE
(Homo
sapiens)		10 / 10LEU A 100
ASP A 103
ASP A 107
ARG A 112
THR A 167
GLN A 171
THR A 201
GLN A 240
ASP A 243
LYS A 257
None
MG  A 405 (-2.5A)
MG  A 405 (-2.4A)
ZOL  A 401 ( 2.7A)
None
ZOL  A 401 ( 3.8A)
ZOL  A 401 (-3.7A)
ZOL  A 401 (-3.5A)
MG  A 404 (-2.8A)
1WO  A 402 ( 2.8A)
0.29A99.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NG6_A_RISA405_1
(FARNESYL
PYROPHOSPHATE
SYNTHASE)		2b49 PROTEIN TYROSINE
PHOSPHATASE,
NON-RECEPTOR TYPE 3
(Homo
sapiens)		5 / 12ASP A 760
THR A 747
LEU A 746
THR A 745
GLN A 805
None
1.32A20.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NG6_A_RISA405_1
(FARNESYL
PYROPHOSPHATE
SYNTHASE)		2q80 GERANYLGERANYL
PYROPHOSPHATE
SYNTHETASE
(Homo
sapiens)		7 / 12LEU A  61
ASP A  64
ASP A  68
ARG A  73
GLN A 126
GLN A 185
ASP A 188
None
GRG  A 500 (-2.4A)
MG  A 400 (-2.6A)
GRG  A 500 (-2.9A)
GRG  A 500 ( 3.5A)
GRG  A 500 (-3.2A)
GRG  A 500 (-3.5A)
0.71A26.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NG6_A_RISA405_1
(FARNESYL
PYROPHOSPHATE
SYNTHASE)		2q80 GERANYLGERANYL
PYROPHOSPHATE
SYNTHETASE
(Homo
sapiens)		6 / 12LEU A  61
ASP A  64
ASP A  68
ARG A  73
GLN A 126
THR A 152
None
GRG  A 500 (-2.4A)
MG  A 400 (-2.6A)
GRG  A 500 (-2.9A)
GRG  A 500 ( 3.5A)
GRG  A 500 ( 4.6A)
0.93A26.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NG6_A_RISA405_1
(FARNESYL
PYROPHOSPHATE
SYNTHASE)		3mop INTERLEUKIN-1
RECEPTOR-ASSOCIATED
KINASE 4
(Homo
sapiens)		5 / 12LEU G 100
ASP G 103
THR G   9
THR G  80
ASP G  86
None
1.38A14.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NG6_A_RISA405_1
(FARNESYL
PYROPHOSPHATE
SYNTHASE)		4flc ADENYLOSUCCINATE
LYASE
(Homo
sapiens)		5 / 12LEU A 121
ASP A 117
THR A 239
THR A 244
ASP A 248
None
1.20A22.53
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4NG6_A_RISA405_1
(FARNESYL
PYROPHOSPHATE
SYNTHASE)		4p0v FARNESYL
PYROPHOSPHATE
SYNTHASE
(Homo
sapiens)		10 / 12LEU A 100
ASP A 103
ASP A 107
ARG A 112
THR A 167
GLN A 171
THR A 201
GLN A 240
ASP A 243
LYS A 257
None
MG  A 405 (-2.5A)
MG  A 405 (-2.4A)
ZOL  A 401 ( 2.7A)
None
ZOL  A 401 ( 3.8A)
ZOL  A 401 (-3.7A)
ZOL  A 401 (-3.5A)
MG  A 404 (-2.8A)
1WO  A 402 ( 2.8A)
0.53A99.71
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4NG6_A_RISA405_1
(FARNESYL
PYROPHOSPHATE
SYNTHASE)		4p0v FARNESYL
PYROPHOSPHATE
SYNTHASE
(Homo
sapiens)		10 / 12LEU A 100
ASP A 103
ASP A 107
ARG A 112
THR A 167
THR A 201
TYR A 204
GLN A 240
ASP A 243
LYS A 257
None
MG  A 405 (-2.5A)
MG  A 405 (-2.4A)
ZOL  A 401 ( 2.7A)
None
ZOL  A 401 (-3.7A)
None
ZOL  A 401 (-3.5A)
MG  A 404 (-2.8A)
1WO  A 402 ( 2.8A)
0.33A99.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NG6_A_RISA405_1
(FARNESYL
PYROPHOSPHATE
SYNTHASE)		4qdr NEUROPILIN-2
(Homo
sapiens)		5 / 12ASP A 301
THR A 298
THR A 305
GLN A 308
ASP A 315
None
1.30A22.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NKE_A_RISA404_1
(FARNESYL
PYROPHOSPHATE
SYNTHASE)		2q80 GERANYLGERANYL
PYROPHOSPHATE
SYNTHETASE
(Homo
sapiens)		5 / 10LEU A  61
ARG A  73
LYS A 151
GLN A 185
LYS A 202
None
GRG  A 500 (-2.9A)
GRG  A 500 (-2.8A)
GRG  A 500 (-3.2A)
GRG  A 500 ( 2.6A)
1.04A26.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NKE_A_RISA404_1
(FARNESYL
PYROPHOSPHATE
SYNTHASE)		2q80 GERANYLGERANYL
PYROPHOSPHATE
SYNTHETASE
(Homo
sapiens)		8 / 10LEU A  61
ASP A  64
ASP A  68
ARG A  73
GLN A 126
LYS A 151
GLN A 185
ASP A 188
None
GRG  A 500 (-2.4A)
MG  A 400 (-2.6A)
GRG  A 500 (-2.9A)
GRG  A 500 ( 3.5A)
GRG  A 500 (-2.8A)
GRG  A 500 (-3.2A)
GRG  A 500 (-3.5A)
0.63A26.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NKE_A_RISA404_1
(FARNESYL
PYROPHOSPHATE
SYNTHASE)		2q80 GERANYLGERANYL
PYROPHOSPHATE
SYNTHETASE
(Homo
sapiens)		6 / 10LEU A  61
ASP A  68
ARG A  73
GLN A 126
LYS A 151
THR A 152
None
MG  A 400 (-2.6A)
GRG  A 500 (-2.9A)
GRG  A 500 ( 3.5A)
GRG  A 500 (-2.8A)
GRG  A 500 ( 4.6A)
0.80A26.63
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4NKE_A_RISA404_1
(FARNESYL
PYROPHOSPHATE
SYNTHASE)		4p0v FARNESYL
PYROPHOSPHATE
SYNTHASE
(Homo
sapiens)		10 / 10LEU A 100
ASP A 103
ASP A 107
ARG A 112
GLN A 171
LYS A 200
THR A 201
GLN A 240
ASP A 243
LYS A 257
None
MG  A 405 (-2.5A)
MG  A 405 (-2.4A)
ZOL  A 401 ( 2.7A)
ZOL  A 401 ( 3.8A)
ZOL  A 401 (-2.7A)
ZOL  A 401 (-3.7A)
ZOL  A 401 (-3.5A)
MG  A 404 (-2.8A)
1WO  A 402 ( 2.8A)
0.38A99.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NUA_A_RISA901_1
(FARNESYL
PYROPHOSPHATE
SYNTHASE)		2q80 GERANYLGERANYL
PYROPHOSPHATE
SYNTHETASE
(Homo
sapiens)		7 / 10LEU A  61
ARG A  73
GLN A 126
LYS A 151
GLN A 185
ASP A 188
LYS A 202
None
GRG  A 500 (-2.9A)
GRG  A 500 ( 3.5A)
GRG  A 500 (-2.8A)
GRG  A 500 (-3.2A)
GRG  A 500 (-3.5A)
GRG  A 500 ( 2.6A)
1.01A26.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NUA_A_RISA901_1
(FARNESYL
PYROPHOSPHATE
SYNTHASE)		2q80 GERANYLGERANYL
PYROPHOSPHATE
SYNTHETASE
(Homo
sapiens)		5 / 10LEU A  61
ARG A  73
GLN A 126
LYS A 151
THR A 152
None
GRG  A 500 (-2.9A)
GRG  A 500 ( 3.5A)
GRG  A 500 (-2.8A)
GRG  A 500 ( 4.6A)
0.86A26.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NUA_A_RISA901_1
(FARNESYL
PYROPHOSPHATE
SYNTHASE)		2q80 GERANYLGERANYL
PYROPHOSPHATE
SYNTHETASE
(Homo
sapiens)		8 / 10LEU A  61
ASP A  64
ASP A  68
ARG A  73
GLN A 126
LYS A 151
GLN A 185
ASP A 188
None
GRG  A 500 (-2.4A)
MG  A 400 (-2.6A)
GRG  A 500 (-2.9A)
GRG  A 500 ( 3.5A)
GRG  A 500 (-2.8A)
GRG  A 500 (-3.2A)
GRG  A 500 (-3.5A)
0.64A26.63
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4NUA_A_RISA901_1
(FARNESYL
PYROPHOSPHATE
SYNTHASE)		4p0v FARNESYL
PYROPHOSPHATE
SYNTHASE
(Homo
sapiens)		10 / 10LEU A 100
ASP A 103
ASP A 107
ARG A 112
GLN A 171
LYS A 200
THR A 201
GLN A 240
ASP A 243
LYS A 257
None
MG  A 405 (-2.5A)
MG  A 405 (-2.4A)
ZOL  A 401 ( 2.7A)
ZOL  A 401 ( 3.8A)
ZOL  A 401 (-2.7A)
ZOL  A 401 (-3.7A)
ZOL  A 401 (-3.5A)
MG  A 404 (-2.8A)
1WO  A 402 ( 2.8A)
0.44A99.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Q23_A_RISA901_1
(FARNESYL
PYROPHOSPHATE
SYNTHASE)		2q80 GERANYLGERANYL
PYROPHOSPHATE
SYNTHETASE
(Homo
sapiens)		6 / 10LEU A  61
ARG A  73
GLN A 126
LYS A 151
GLN A 185
LYS A 202
None
GRG  A 500 (-2.9A)
GRG  A 500 ( 3.5A)
GRG  A 500 (-2.8A)
GRG  A 500 (-3.2A)
GRG  A 500 ( 2.6A)
1.29A26.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Q23_A_RISA901_1
(FARNESYL
PYROPHOSPHATE
SYNTHASE)		2q80 GERANYLGERANYL
PYROPHOSPHATE
SYNTHETASE
(Homo
sapiens)		8 / 10LEU A  61
ASP A  64
ASP A  68
ARG A  73
GLN A 126
LYS A 151
GLN A 185
ASP A 188
None
GRG  A 500 (-2.4A)
MG  A 400 (-2.6A)
GRG  A 500 (-2.9A)
GRG  A 500 ( 3.5A)
GRG  A 500 (-2.8A)
GRG  A 500 (-3.2A)
GRG  A 500 (-3.5A)
0.65A26.63
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4Q23_A_RISA901_1
(FARNESYL
PYROPHOSPHATE
SYNTHASE)		4p0v FARNESYL
PYROPHOSPHATE
SYNTHASE
(Homo
sapiens)		10 / 10LEU A 100
ASP A 103
ASP A 107
ARG A 112
GLN A 171
LYS A 200
TYR A 204
GLN A 240
ASP A 243
LYS A 257
None
MG  A 405 (-2.5A)
MG  A 405 (-2.4A)
ZOL  A 401 ( 2.7A)
ZOL  A 401 ( 3.8A)
ZOL  A 401 (-2.7A)
None
ZOL  A 401 (-3.5A)
MG  A 404 (-2.8A)
1WO  A 402 ( 2.8A)
0.21A99.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RXD_A_RISA1404_1
(FARNESYL
PYROPHOSPHATE
SYNTHASE)		2q80 GERANYLGERANYL
PYROPHOSPHATE
SYNTHETASE
(Homo
sapiens)		6 / 10LEU A  61
ARG A  73
GLN A 126
LYS A 151
GLN A 185
LYS A 202
None
GRG  A 500 (-2.9A)
GRG  A 500 ( 3.5A)
GRG  A 500 (-2.8A)
GRG  A 500 (-3.2A)
GRG  A 500 ( 2.6A)
1.20A24.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RXD_A_RISA1404_1
(FARNESYL
PYROPHOSPHATE
SYNTHASE)		2q80 GERANYLGERANYL
PYROPHOSPHATE
SYNTHETASE
(Homo
sapiens)		8 / 10LEU A  61
ASP A  64
ASP A  68
ARG A  73
GLN A 126
LYS A 151
GLN A 185
ASP A 188
None
GRG  A 500 (-2.4A)
MG  A 400 (-2.6A)
GRG  A 500 (-2.9A)
GRG  A 500 ( 3.5A)
GRG  A 500 (-2.8A)
GRG  A 500 (-3.2A)
GRG  A 500 (-3.5A)
0.65A24.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RXD_A_RISA1404_1
(FARNESYL
PYROPHOSPHATE
SYNTHASE)		2q80 GERANYLGERANYL
PYROPHOSPHATE
SYNTHETASE
(Homo
sapiens)		6 / 10LEU A  61
ASP A  68
ARG A  73
GLN A 126
LYS A 151
THR A 152
None
MG  A 400 (-2.6A)
GRG  A 500 (-2.9A)
GRG  A 500 ( 3.5A)
GRG  A 500 (-2.8A)
GRG  A 500 ( 4.6A)
0.82A24.74
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4RXD_A_RISA1404_1
(FARNESYL
PYROPHOSPHATE
SYNTHASE)		4p0v FARNESYL
PYROPHOSPHATE
SYNTHASE
(Homo
sapiens)		10 / 10LEU A 100
ASP A 103
ASP A 107
ARG A 112
GLN A 171
LYS A 200
THR A 201
GLN A 240
ASP A 243
LYS A 257
None
MG  A 405 (-2.5A)
MG  A 405 (-2.4A)
ZOL  A 401 ( 2.7A)
ZOL  A 401 ( 3.8A)
ZOL  A 401 (-2.7A)
ZOL  A 401 (-3.7A)
ZOL  A 401 (-3.5A)
MG  A 404 (-2.8A)
1WO  A 402 ( 2.8A)
0.26A37.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RXD_B_RISB1504_1
(FARNESYL
PYROPHOSPHATE
SYNTHASE)		2q80 GERANYLGERANYL
PYROPHOSPHATE
SYNTHETASE
(Homo
sapiens)		6 / 10LEU A  61
ARG A  73
GLN A 126
LYS A 151
GLN A 185
LYS A 202
None
GRG  A 500 (-2.9A)
GRG  A 500 ( 3.5A)
GRG  A 500 (-2.8A)
GRG  A 500 (-3.2A)
GRG  A 500 ( 2.6A)
1.22A24.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RXD_B_RISB1504_1
(FARNESYL
PYROPHOSPHATE
SYNTHASE)		2q80 GERANYLGERANYL
PYROPHOSPHATE
SYNTHETASE
(Homo
sapiens)		8 / 10LEU A  61
ASP A  64
ASP A  68
ARG A  73
GLN A 126
LYS A 151
GLN A 185
ASP A 188
None
GRG  A 500 (-2.4A)
MG  A 400 (-2.6A)
GRG  A 500 (-2.9A)
GRG  A 500 ( 3.5A)
GRG  A 500 (-2.8A)
GRG  A 500 (-3.2A)
GRG  A 500 (-3.5A)
0.64A24.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RXD_B_RISB1504_1
(FARNESYL
PYROPHOSPHATE
SYNTHASE)		2q80 GERANYLGERANYL
PYROPHOSPHATE
SYNTHETASE
(Homo
sapiens)		6 / 10LEU A  61
ASP A  68
ARG A  73
GLN A 126
LYS A 151
THR A 152
None
MG  A 400 (-2.6A)
GRG  A 500 (-2.9A)
GRG  A 500 ( 3.5A)
GRG  A 500 (-2.8A)
GRG  A 500 ( 4.6A)
0.81A24.74
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4RXD_B_RISB1504_1
(FARNESYL
PYROPHOSPHATE
SYNTHASE)		4p0v FARNESYL
PYROPHOSPHATE
SYNTHASE
(Homo
sapiens)		10 / 10LEU A 100
ASP A 103
ASP A 107
ARG A 112
GLN A 171
LYS A 200
THR A 201
GLN A 240
ASP A 243
LYS A 257
None
MG  A 405 (-2.5A)
MG  A 405 (-2.4A)
ZOL  A 401 ( 2.7A)
ZOL  A 401 ( 3.8A)
ZOL  A 401 (-2.7A)
ZOL  A 401 (-3.7A)
ZOL  A 401 (-3.5A)
MG  A 404 (-2.8A)
1WO  A 402 ( 2.8A)
0.25A37.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RXD_C_RISC1600_1
(FARNESYL
PYROPHOSPHATE
SYNTHASE)		2q80 GERANYLGERANYL
PYROPHOSPHATE
SYNTHETASE
(Homo
sapiens)		6 / 10LEU A  61
ARG A  73
GLN A 126
LYS A 151
GLN A 185
LYS A 202
None
GRG  A 500 (-2.9A)
GRG  A 500 ( 3.5A)
GRG  A 500 (-2.8A)
GRG  A 500 (-3.2A)
GRG  A 500 ( 2.6A)
1.22A24.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RXD_C_RISC1600_1
(FARNESYL
PYROPHOSPHATE
SYNTHASE)		2q80 GERANYLGERANYL
PYROPHOSPHATE
SYNTHETASE
(Homo
sapiens)		8 / 10LEU A  61
ASP A  64
ASP A  68
ARG A  73
GLN A 126
LYS A 151
GLN A 185
ASP A 188
None
GRG  A 500 (-2.4A)
MG  A 400 (-2.6A)
GRG  A 500 (-2.9A)
GRG  A 500 ( 3.5A)
GRG  A 500 (-2.8A)
GRG  A 500 (-3.2A)
GRG  A 500 (-3.5A)
0.64A24.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RXD_C_RISC1600_1
(FARNESYL
PYROPHOSPHATE
SYNTHASE)		2q80 GERANYLGERANYL
PYROPHOSPHATE
SYNTHETASE
(Homo
sapiens)		7 / 10LEU A  61
ASP A  64
ASP A  68
ARG A  73
GLN A 126
LYS A 151
THR A 152
None
GRG  A 500 (-2.4A)
MG  A 400 (-2.6A)
GRG  A 500 (-2.9A)
GRG  A 500 ( 3.5A)
GRG  A 500 (-2.8A)
GRG  A 500 ( 4.6A)
0.77A24.74
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4RXD_C_RISC1600_1
(FARNESYL
PYROPHOSPHATE
SYNTHASE)		4p0v FARNESYL
PYROPHOSPHATE
SYNTHASE
(Homo
sapiens)		10 / 10LEU A 100
ASP A 103
ASP A 107
ARG A 112
GLN A 171
LYS A 200
THR A 201
GLN A 240
ASP A 243
LYS A 257
None
MG  A 405 (-2.5A)
MG  A 405 (-2.4A)
ZOL  A 401 ( 2.7A)
ZOL  A 401 ( 3.8A)
ZOL  A 401 (-2.7A)
ZOL  A 401 (-3.7A)
ZOL  A 401 (-3.5A)
MG  A 404 (-2.8A)
1WO  A 402 ( 2.8A)
0.26A37.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5CG5_A_RISA400_1
(FARNESYL
PYROPHOSPHATE
SYNTHASE)		2q80 GERANYLGERANYL
PYROPHOSPHATE
SYNTHETASE
(Homo
sapiens)		5 / 12ASP A  68
ARG A  73
GLN A 126
LYS A 151
THR A 152
 MG  A 400 (-2.6A)
GRG  A 500 (-2.9A)
GRG  A 500 ( 3.5A)
GRG  A 500 (-2.8A)
GRG  A 500 ( 4.6A)
0.88A27.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5CG5_A_RISA400_1
(FARNESYL
PYROPHOSPHATE
SYNTHASE)		2q80 GERANYLGERANYL
PYROPHOSPHATE
SYNTHETASE
(Homo
sapiens)		6 / 12LEU A  61
ARG A  73
GLN A 126
LYS A 151
GLN A 185
LYS A 202
None
GRG  A 500 (-2.9A)
GRG  A 500 ( 3.5A)
GRG  A 500 (-2.8A)
GRG  A 500 (-3.2A)
GRG  A 500 ( 2.6A)
1.15A27.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5CG5_A_RISA400_1
(FARNESYL
PYROPHOSPHATE
SYNTHASE)		2q80 GERANYLGERANYL
PYROPHOSPHATE
SYNTHETASE
(Homo
sapiens)		8 / 12LEU A  61
ASP A  64
ASP A  68
ARG A  73
GLN A 126
LYS A 151
GLN A 185
ASP A 188
None
GRG  A 500 (-2.4A)
MG  A 400 (-2.6A)
GRG  A 500 (-2.9A)
GRG  A 500 ( 3.5A)
GRG  A 500 (-2.8A)
GRG  A 500 (-3.2A)
GRG  A 500 (-3.5A)
0.64A27.15
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5CG5_A_RISA400_1
(FARNESYL
PYROPHOSPHATE
SYNTHASE)		4p0v FARNESYL
PYROPHOSPHATE
SYNTHASE
(Homo
sapiens)		12 / 12LEU A 100
ASP A 103
ASP A 107
ARG A 112
THR A 167
GLN A 171
LYS A 200
THR A 201
TYR A 204
GLN A 240
ASP A 243
LYS A 257
None
MG  A 405 (-2.5A)
MG  A 405 (-2.4A)
ZOL  A 401 ( 2.7A)
None
ZOL  A 401 ( 3.8A)
ZOL  A 401 (-2.7A)
ZOL  A 401 (-3.7A)
None
ZOL  A 401 (-3.5A)
MG  A 404 (-2.8A)
1WO  A 402 ( 2.8A)
0.23A99.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5CG6_A_RISA404_1
(FARNESYL
PYROPHOSPHATE
SYNTHASE)		2q80 GERANYLGERANYL
PYROPHOSPHATE
SYNTHETASE
(Homo
sapiens)		6 / 12LEU A  61
ARG A  73
GLN A 126
LYS A 151
GLN A 185
LYS A 202
None
GRG  A 500 (-2.9A)
GRG  A 500 ( 3.5A)
GRG  A 500 (-2.8A)
GRG  A 500 (-3.2A)
GRG  A 500 ( 2.6A)
1.26A27.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5CG6_A_RISA404_1
(FARNESYL
PYROPHOSPHATE
SYNTHASE)		2q80 GERANYLGERANYL
PYROPHOSPHATE
SYNTHETASE
(Homo
sapiens)		8 / 12LEU A  61
ASP A  64
ASP A  68
ARG A  73
GLN A 126
LYS A 151
GLN A 185
ASP A 188
None
GRG  A 500 (-2.4A)
MG  A 400 (-2.6A)
GRG  A 500 (-2.9A)
GRG  A 500 ( 3.5A)
GRG  A 500 (-2.8A)
GRG  A 500 (-3.2A)
GRG  A 500 (-3.5A)
0.62A27.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5CG6_A_RISA404_1
(FARNESYL
PYROPHOSPHATE
SYNTHASE)		2q80 GERANYLGERANYL
PYROPHOSPHATE
SYNTHETASE
(Homo
sapiens)		7 / 12LEU A  61
ASP A  64
ASP A  68
ARG A  73
GLN A 126
LYS A 151
THR A 152
None
GRG  A 500 (-2.4A)
MG  A 400 (-2.6A)
GRG  A 500 (-2.9A)
GRG  A 500 ( 3.5A)
GRG  A 500 (-2.8A)
GRG  A 500 ( 4.6A)
0.75A27.15
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5CG6_A_RISA404_1
(FARNESYL
PYROPHOSPHATE
SYNTHASE)		4p0v FARNESYL
PYROPHOSPHATE
SYNTHASE
(Homo
sapiens)		12 / 12PHE A  99
LEU A 100
ASP A 103
ASP A 107
ARG A 112
THR A 167
GLN A 171
LYS A 200
THR A 201
GLN A 240
ASP A 243
LYS A 257
None
None
MG  A 405 (-2.5A)
MG  A 405 (-2.4A)
ZOL  A 401 ( 2.7A)
None
ZOL  A 401 ( 3.8A)
ZOL  A 401 (-2.7A)
ZOL  A 401 (-3.7A)
ZOL  A 401 (-3.5A)
MG  A 404 (-2.8A)
1WO  A 402 ( 2.8A)
0.23A99.71