POTENTIAL TARGETS FROM HUMAN (RESULTS FROM SUB-STRUCTURAL SIMILARITY SEARCHES)
1) User may click on the DrReposER ID (the second column) to get information on the binding sites and drug molecule.
2) Click View (the second last column) to view matched residues and superposition in the NGL viewer (upper right part).
3) User may also click on the Dock (the last column) to get script for molecular docking in UCSF Chimera through AutoDock Vina.


DrReposER ID / Desc. Hit
PDBID
Hit
Macromolecule
Res.
Matches
Interface HETATM RMSD Seq.
Identity (%)
View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2RLF_A_RIMA199_1
(MATRIX PROTEIN 2)
1olx 2-OXOISOVALERATE
DEHYDROGENASE BETA
SUBUNIT
(Homo
sapiens)
4 / 6LEU B 275
LEU B 276
ILE B 291
ARG B 309
None
1.01A11.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2RLF_A_RIMA199_1
(MATRIX PROTEIN 2)
1tu3 RAB GTPASE BINDING
EFFECTOR PROTEIN 1
(Homo
sapiens)
4 / 6LEU F 832
LEU F 828
ILE F 835
ARG F 834
None
0.89A13.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2RLF_A_RIMA199_1
(MATRIX PROTEIN 2)
1xa6 BETA2-CHIMAERIN
(Homo
sapiens)
4 / 6LEU A 266
ASP A 265
ILE A 269
ARG A 268
None
0.93A8.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2RLF_A_RIMA199_1
(MATRIX PROTEIN 2)
2hgs PROTEIN (GLUTATHIONE
SYNTHETASE)
(Homo
sapiens)
4 / 6LEU A 426
LEU A 449
ILE A 428
ARG A 125
None
None
None
SO4  A 505 ( 3.0A)
1.07A8.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2RLF_A_RIMA199_1
(MATRIX PROTEIN 2)
2oq5 TRANSMEMBRANE
PROTEASE, SERINE 11E
(Homo
sapiens)
4 / 6LEU A  85
LEU A 108
ILE A  88
ARG A  87
None
0.93A10.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2RLF_A_RIMA199_1
(MATRIX PROTEIN 2)
2q9q DNA REPLICATION
COMPLEX GINS PROTEIN
PSF1
(Homo
sapiens)
4 / 6LEU C  84
LEU C  80
ILE C  87
ARG C  86
None
0.98A12.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2RLF_A_RIMA199_1
(MATRIX PROTEIN 2)
2w7a LINE-1 ORF1P
(Homo
sapiens)
4 / 6LEU A 160
LEU A 158
ILE A 247
ARG A 248
None
1.05A16.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2RLF_A_RIMA199_1
(MATRIX PROTEIN 2)
2xac VASCULAR ENDOTHELIAL
GROWTH FACTOR B
(Homo
sapiens)
4 / 6LEU A  81
LEU A  90
ILE A  83
ARG A  84
None
1.06A13.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2RLF_A_RIMA199_1
(MATRIX PROTEIN 2)
3iq2 SORTING NEXIN-7
(Homo
sapiens)
4 / 6LEU A 125
LEU A 121
ILE A 128
ARG A 127
None
0.78A20.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2RLF_A_RIMA199_1
(MATRIX PROTEIN 2)
3w4u HEMOGLOBIN SUBUNIT
ZETA
(Homo
sapiens)
4 / 6LEU A 109
LEU A 106
ILE A  24
ARG A  31
None
1.05A20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2RLF_A_RIMA199_1
(MATRIX PROTEIN 2)
4bc5 XYLULOSE KINASE
(Homo
sapiens)
4 / 6LEU A 121
LEU A  72
ASP A  73
ARG A 120
None
0.93A6.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2RLF_A_RIMA199_1
(MATRIX PROTEIN 2)
4r0i SUPPRESSOR OF
TUMORIGENICITY 14
PROTEIN
(Homo
sapiens)
4 / 6LEU A  85
LEU A 108
ILE A  88
ARG A  87
None
0.83A9.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2RLF_A_RIMA199_1
(MATRIX PROTEIN 2)
4rz9 PRE-MRNA-SPLICING
FACTOR 38A
(Homo
sapiens)
4 / 6LEU A 123
ASP A 126
ILE A 130
ARG A 128
None
0.99A11.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2RLF_A_RIMA199_1
(MATRIX PROTEIN 2)
4u9v N-ALPHA-ACETYLTRANSF
ERASE 40
(Homo
sapiens)
4 / 6LEU B 173
LEU B 214
ILE B 156
ARG B 216
ACO  B 301 ( 4.2A)
None
None
None
1.01A10.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2RLF_A_RIMA199_1
(MATRIX PROTEIN 2)
4wtv PHOSPHATIDYLINOSITOL
4-KINASE TYPE
2-BETA,ENDOLYSIN,PHO
SPHATIDYLINOSITOL
4-KINASE TYPE 2-BETA
(Escherichia
virus
T4;
Homo
sapiens)
4 / 6LEU A 293
LEU A 296
ASP A 297
TRP A 364
None
1.05A6.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2RLF_A_RIMA199_1
(MATRIX PROTEIN 2)
4yu9 GLUTAMINYL-PEPTIDE
CYCLOTRANSFERASE
(Homo
sapiens)
4 / 6LEU A  73
LEU A  70
ILE A  91
ARG A  94
None
0.94A9.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2RLF_A_RIMA199_1
(MATRIX PROTEIN 2)
4zih APOPTOSIS REGULATOR
BAX
(Homo
sapiens)
4 / 6LEU A  63
LEU A  59
ILE A  66
ARG A  65
None
0.87A14.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2RLF_A_RIMA199_1
(MATRIX PROTEIN 2)
5gl7 METHIONINE--TRNA
LIGASE, CYTOPLASMIC
(Homo
sapiens)
4 / 6LEU A 622
LEU A 621
ILE A 701
ARG A 702
None
0.95A5.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2RLF_A_RIMA199_1
(MATRIX PROTEIN 2)
5nqa POLYPEPTIDE
N-ACETYLGALACTOSAMIN
YLTRANSFERASE 4
(Homo
sapiens)
4 / 6LEU A 474
LEU A 458
ILE A 453
ARG A 449
None
1.03A22.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2RLF_A_RIMA199_1
(MATRIX PROTEIN 2)
5u2n NICOTINAMIDE
PHOSPHORIBOSYLTRANSF
ERASE
(Homo
sapiens)
4 / 6LEU A 325
LEU A 328
ILE A 378
ARG A 349
None
1.04A7.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2RLF_A_RIMA199_1
(MATRIX PROTEIN 2)
5xgc RAP1 GTPASE-GDP
DISSOCIATION
STIMULATOR 1
(Homo
sapiens)
4 / 6LEU A 424
LEU A 421
ILE A 381
ARG A 378
None
1.03A6.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2RLF_A_RIMA199_1
(MATRIX PROTEIN 2)
6eti ATP-BINDING CASSETTE
SUB-FAMILY G MEMBER
2
(Homo
sapiens)
4 / 6LEU A 228
LEU A 225
ILE A 196
ARG A 193
None
0.83A20.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2RLF_A_RIMA199_1
(MATRIX PROTEIN 2)
6f1t CYTOPLASMIC DYNEIN 1
HEAVY CHAIN
1,CYTOPLASMIC DYNEIN
1 HEAVY CHAIN
1,CYTOPLASMIC DYNEIN
1 HEAVY CHAIN
1,DYNEIN HEAVY
CHAIN,CYTOPLASMIC
DYNEIN 1 HEAVY CHAIN
1,CYTOPLASMIC DYNEIN
1 HEAVY CHAIN
1,CYTOPLASMIC DYNEIN
1 HEAVY CHAIN
1,CYTOPLASMIC DYNEIN
1 HEAVY CHAIN
1,DYNEIN HEAVY
CHAIN,CYTOPLASMIC
DYNEIN 1 HEAVY CHAIN
1,CYTOPLASMIC DYNEIN
1 HEAVY CHAIN 1
(Homo
sapiens)
4 / 6LEU e 285
LEU e 281
ILE e 288
ARG e 287
None
0.96A24.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2RLF_B_RIMB299_1
(MATRIX PROTEIN 2)
1qqg INSULIN RECEPTOR
SUBSTRATE 1
(Homo
sapiens)
4 / 6LEU A  66
LEU A 113
ILE A  64
ARG A  43
None
1.03A9.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2RLF_B_RIMB299_1
(MATRIX PROTEIN 2)
2afg ACIDIC FIBROBLAST
GROWTH FACTOR
(Homo
sapiens)
4 / 6LEU A  23
LEU A 111
ILE A  25
ARG A  24
None
1.16A16.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2RLF_B_RIMB299_1
(MATRIX PROTEIN 2)
2hgs PROTEIN (GLUTATHIONE
SYNTHETASE)
(Homo
sapiens)
4 / 6LEU A 207
LEU A 205
ILE A 242
ARG A 237
None
1.14A8.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2RLF_B_RIMB299_1
(MATRIX PROTEIN 2)
2no2 HUNTINGTIN-INTERACTI
NG PROTEIN 1
(Homo
sapiens)
4 / 6LEU A 517
LEU A 513
ILE A 520
ARG A 519
None
0.93A15.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2RLF_B_RIMB299_1
(MATRIX PROTEIN 2)
2ocf ESTROGEN RECEPTOR
(Homo
sapiens)
4 / 6LEU A 539
LEU A 540
ASP A 351
ILE A 358
None
1.14A16.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2RLF_B_RIMB299_1
(MATRIX PROTEIN 2)
2ocf ESTROGEN RECEPTOR
FIBRONECTIN
(Homo
sapiens)
4 / 6LEU A 539
LEU A 540
ASP A 351
ARG D  33
None
1.15A16.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2RLF_B_RIMB299_1
(MATRIX PROTEIN 2)
2v5o CATION-INDEPENDENT
MANNOSE-6-PHOSPHATE
RECEPTOR
(Homo
sapiens)
4 / 6LEU A2028
LEU A2005
TRP A2015
ILE A2026
None
1.15A5.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2RLF_B_RIMB299_1
(MATRIX PROTEIN 2)
2xwu IMPORTIN13
(Homo
sapiens)
4 / 6LEU B 450
LEU B 453
ILE B 495
ARG B 497
None
0.93A3.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2RLF_B_RIMB299_1
(MATRIX PROTEIN 2)
3g04 THYROTROPIN RECEPTOR
(Homo
sapiens)
4 / 6LEU C  64
LEU C  89
ASP C  86
ILE C  44
None
1.16A10.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2RLF_B_RIMB299_1
(MATRIX PROTEIN 2)
3su8 PLEXIN-B1
(Homo
sapiens)
4 / 6LEU X1958
ASP X1959
ILE X2056
ARG X2057
None
1.17A6.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2RLF_B_RIMB299_1
(MATRIX PROTEIN 2)
4hne PHOSPHATIDYLINOSITOL
4-KINASE TYPE
2-ALPHA
(Homo
sapiens)
4 / 6LEU A 297
LEU A 300
ASP A 301
TRP A 366
LEU  A 297 ( 0.5A)
LEU  A 300 ( 0.5A)
ASP  A 301 ( 0.6A)
TRP  A 366 ( 0.5A)
1.08A7.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2RLF_B_RIMB299_1
(MATRIX PROTEIN 2)
4or2 SOLUBLE CYTOCHROME
B562, METABOTROPIC
GLUTAMATE RECEPTOR 1
(Escherichia
coli;
Homo
sapiens)
4 / 6LEU A1010
LEU A1014
TRP A1007
ILE A1102
None
0.95A11.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2RLF_B_RIMB299_1
(MATRIX PROTEIN 2)
4wtv PHOSPHATIDYLINOSITOL
4-KINASE TYPE
2-BETA,ENDOLYSIN,PHO
SPHATIDYLINOSITOL
4-KINASE TYPE 2-BETA
(Escherichia
virus
T4;
Homo
sapiens)
4 / 6LEU A 293
LEU A 296
ASP A 297
TRP A 364
None
0.95A6.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2RLF_B_RIMB299_1
(MATRIX PROTEIN 2)
5eut PHOSPHATIDYLINOSITOL
4-KINASE TYPE
2-ALPHA,ENDOLYSIN,PH
OSPHATIDYLINOSITOL
4-KINASE TYPE
2-ALPHA
(Escherichia
virus
T4;
Homo
sapiens)
4 / 6LEU A 297
LEU A 300
ASP A 301
TRP A 366
None
1.01A13.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2RLF_B_RIMB299_1
(MATRIX PROTEIN 2)
5fwm HEAT SHOCK PROTEIN
HSP 90 BETA
(Homo
sapiens)
4 / 6LEU A 657
LEU A 654
ILE A 680
ARG A 682
None
0.88A6.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2RLF_B_RIMB299_1
(MATRIX PROTEIN 2)
5iy9 DNA-DIRECTED RNA
POLYMERASE II
SUBUNIT RPB1
DNA-DIRECTED RNA
POLYMERASE II
SUBUNIT RPB6
(Homo
sapiens)
4 / 6LEU F  90
LEU F  91
ASP F  88
ILE A 455
None
1.10A16.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2RLF_B_RIMB299_1
(MATRIX PROTEIN 2)
5nwm NUCLEAR RECEPTOR
COACTIVATOR 1
SIGNAL TRANSDUCER
AND ACTIVATOR OF
TRANSCRIPTION 6
(Homo
sapiens)
4 / 6LEU B 805
LEU B 802
ASP B 801
ILE A 273
None
1.06A19.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2RLF_B_RIMB299_1
(MATRIX PROTEIN 2)
5toa ESTROGEN RECEPTOR
BETA
(Homo
sapiens)
4 / 6LEU A 491
LEU A 492
ASP A 489
TRP A 335
None
1.16A14.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2RLF_B_RIMB299_1
(MATRIX PROTEIN 2)
6dd3 CYTOSOLIC PURINE
5'-NUCLEOTIDASE
(Homo
sapiens)
4 / 6LEU A 392
LEU A 388
ILE A 423
ARG A 422
None
1.10A17.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2RLF_C_RIMC399_1
(MATRIX PROTEIN 2)
1bo9 PROTEIN (ANNEXIN I)
(Homo
sapiens)
4 / 6LEU A  52
LEU A  56
ILE A  40
ARG A  37
None
0.97A26.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2RLF_C_RIMC399_1
(MATRIX PROTEIN 2)
1bp1 BACTERICIDAL/PERMEAB
ILITY-INCREASING
PROTEIN
(Homo
sapiens)
4 / 6LEU A  29
LEU A  25
ILE A  32
ARG A  31
None
PC1  A 777 ( 4.1A)
None
None
0.99A6.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2RLF_C_RIMC399_1
(MATRIX PROTEIN 2)
1tu3 RAB GTPASE BINDING
EFFECTOR PROTEIN 1
(Homo
sapiens)
4 / 6LEU F 832
LEU F 828
ILE F 835
ARG F 834
None
1.01A13.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2RLF_C_RIMC399_1
(MATRIX PROTEIN 2)
2edw OBSCURIN
(Homo
sapiens)
4 / 6LEU A  64
LEU A  55
ILE A  66
ARG A  67
None
0.76A17.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2RLF_C_RIMC399_1
(MATRIX PROTEIN 2)
2hgs PROTEIN (GLUTATHIONE
SYNTHETASE)
(Homo
sapiens)
4 / 6LEU A 426
LEU A 449
ILE A 428
ARG A 125
None
None
None
SO4  A 505 ( 3.0A)
0.98A8.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2RLF_C_RIMC399_1
(MATRIX PROTEIN 2)
2kdd BOREALIN
(Homo
sapiens)
4 / 6LEU A 269
LEU A 265
ILE A 272
ARG A 268
None
0.91A19.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2RLF_C_RIMC399_1
(MATRIX PROTEIN 2)
2xac VASCULAR ENDOTHELIAL
GROWTH FACTOR B
(Homo
sapiens)
4 / 6LEU A  81
LEU A  90
ILE A  83
ARG A  84
None
0.99A13.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2RLF_C_RIMC399_1
(MATRIX PROTEIN 2)
3iq2 SORTING NEXIN-7
(Homo
sapiens)
4 / 6LEU A 125
LEU A 121
ILE A 128
ARG A 127
None
0.87A20.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2RLF_C_RIMC399_1
(MATRIX PROTEIN 2)
4bc5 XYLULOSE KINASE
(Homo
sapiens)
4 / 6LEU A 121
LEU A  72
ASP A  73
ARG A 120
None
0.95A6.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2RLF_C_RIMC399_1
(MATRIX PROTEIN 2)
4r0i SUPPRESSOR OF
TUMORIGENICITY 14
PROTEIN
(Homo
sapiens)
4 / 6LEU A  85
LEU A 108
ILE A  88
ARG A  87
None
0.97A9.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2RLF_C_RIMC399_1
(MATRIX PROTEIN 2)
4rz9 PRE-MRNA-SPLICING
FACTOR 38A
(Homo
sapiens)
4 / 6LEU A 123
ASP A 126
ILE A 130
ARG A 128
None
0.92A11.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2RLF_C_RIMC399_1
(MATRIX PROTEIN 2)
4u9v N-ALPHA-ACETYLTRANSF
ERASE 40
(Homo
sapiens)
4 / 6LEU B 173
LEU B 214
ILE B 156
ARG B 216
ACO  B 301 ( 4.2A)
None
None
None
0.90A10.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2RLF_C_RIMC399_1
(MATRIX PROTEIN 2)
4yu9 GLUTAMINYL-PEPTIDE
CYCLOTRANSFERASE
(Homo
sapiens)
4 / 6LEU A  73
LEU A  70
ILE A  91
ARG A  94
None
0.98A9.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2RLF_C_RIMC399_1
(MATRIX PROTEIN 2)
5gl7 METHIONINE--TRNA
LIGASE, CYTOPLASMIC
(Homo
sapiens)
4 / 6LEU A 622
LEU A 621
ILE A 701
ARG A 702
None
1.01A5.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2RLF_C_RIMC399_1
(MATRIX PROTEIN 2)
5nqa POLYPEPTIDE
N-ACETYLGALACTOSAMIN
YLTRANSFERASE 4
(Homo
sapiens)
4 / 6LEU A 474
LEU A 458
ILE A 453
ARG A 449
None
0.99A22.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2RLF_C_RIMC399_1
(MATRIX PROTEIN 2)
5u2n NICOTINAMIDE
PHOSPHORIBOSYLTRANSF
ERASE
(Homo
sapiens)
4 / 6LEU A 325
LEU A 328
ILE A 378
ARG A 349
None
0.97A7.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2RLF_C_RIMC399_1
(MATRIX PROTEIN 2)
5u77 OXYSTEROL-BINDING
PROTEIN-RELATED
PROTEIN 8
(Homo
sapiens)
4 / 6LEU A 103
LEU A  98
ILE A 105
ARG A  18
None
NDB  A 201 (-4.3A)
None
None
0.94A16.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2RLF_C_RIMC399_1
(MATRIX PROTEIN 2)
6cwx RIBONUCLEASE P
PROTEIN SUBUNIT P25
(Homo
sapiens)
4 / 6LEU B 135
LEU B  97
ILE B 137
ARG B  96
None
None
None
SO4  B 203 (-4.0A)
1.00A16.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2RLF_C_RIMC399_1
(MATRIX PROTEIN 2)
6eti ATP-BINDING CASSETTE
SUB-FAMILY G MEMBER
2
(Homo
sapiens)
4 / 6LEU A 228
LEU A 225
ILE A 196
ARG A 193
None
0.77A20.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2RLF_C_RIMC399_1
(MATRIX PROTEIN 2)
6f1t CYTOPLASMIC DYNEIN 1
HEAVY CHAIN
1,CYTOPLASMIC DYNEIN
1 HEAVY CHAIN
1,CYTOPLASMIC DYNEIN
1 HEAVY CHAIN
1,DYNEIN HEAVY
CHAIN,CYTOPLASMIC
DYNEIN 1 HEAVY CHAIN
1,CYTOPLASMIC DYNEIN
1 HEAVY CHAIN
1,CYTOPLASMIC DYNEIN
1 HEAVY CHAIN
1,CYTOPLASMIC DYNEIN
1 HEAVY CHAIN
1,DYNEIN HEAVY
CHAIN,CYTOPLASMIC
DYNEIN 1 HEAVY CHAIN
1,CYTOPLASMIC DYNEIN
1 HEAVY CHAIN 1
(Homo
sapiens)
4 / 6LEU e 285
LEU e 281
ILE e 288
ARG e 287
None
0.96A24.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2RLF_D_RIMD499_1
(MATRIX PROTEIN 2)
1ldj CULLIN HOMOLOG 1
(Homo
sapiens)
4 / 6ILE A  28
ARG A  25
LEU A  24
LEU A  96
None
1.06A5.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2RLF_D_RIMD499_1
(MATRIX PROTEIN 2)
2lr8 CASP8-ASSOCIATED
PROTEIN 2
(Homo
sapiens)
4 / 6ILE A  25
ARG A  56
LEU A  60
LEU A  46
None
0.91A18.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2RLF_D_RIMD499_1
(MATRIX PROTEIN 2)
2nmp CYSTATHIONINE
GAMMA-LYASE
(Homo
sapiens)
4 / 6ILE A  41
LEU A  43
LEU A 254
ASP A 251
None
1.02A8.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2RLF_D_RIMD499_1
(MATRIX PROTEIN 2)
3nwn KINESIN-LIKE PROTEIN
KIF9
(Homo
sapiens)
4 / 6TRP A  53
ILE A  35
LEU A 331
LEU A  37
None
1.05A11.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2RLF_D_RIMD499_1
(MATRIX PROTEIN 2)
4o3m BLOOM SYNDROME
PROTEIN
(Homo
sapiens)
4 / 6ILE A 882
ARG A 883
LEU A 908
ASP A 911
None
0.97A6.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2RLF_D_RIMD499_1
(MATRIX PROTEIN 2)
4or2 SOLUBLE CYTOCHROME
B562, METABOTROPIC
GLUTAMATE RECEPTOR 1
(Escherichia
coli;
Homo
sapiens)
4 / 6ILE A1102
ARG A1098
LEU A1068
LEU A1106
None
1.02A11.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2RLF_D_RIMD499_1
(MATRIX PROTEIN 2)
5exr DNA POLYMERASE ALPHA
CATALYTIC SUBUNIT
(Homo
sapiens)
4 / 6ILE C1006
LEU C 858
LEU C 984
ASP C1004
None
1.00A3.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2RLF_D_RIMD499_1
(MATRIX PROTEIN 2)
5n4w CULLIN-2
(Homo
sapiens)
4 / 6ILE A 319
LEU A 315
LEU A 372
ASP A 369
None
1.07A5.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2RLF_D_RIMD499_1
(MATRIX PROTEIN 2)
5n7f MEMBRANE-ASSOCIATED
GUANYLATE KINASE, WW
AND PDZ
DOMAIN-CONTAINING
PROTEIN 1,ANNEXIN A2
(Homo
sapiens)
4 / 6ILE A 671
ARG A 674
LEU A 653
ASP A 649
None
GOL  A 903 ( 3.8A)
None
GOL  A 903 (-3.5A)
1.07A8.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2RLF_D_RIMD499_1
(MATRIX PROTEIN 2)
5ool 39S RIBOSOMAL
PROTEIN L37,
MITOCHONDRIAL
(Homo
sapiens)
4 / 6ILE 5 314
ARG 5 310
LEU 5 355
LEU 5 121
None
1.00A7.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2RLF_D_RIMD499_1
(MATRIX PROTEIN 2)
5veu CYTOCHROME P450 3A5
(Homo
sapiens)
4 / 6ILE A 276
LEU A 261
LEU A 295
ASP A 292
None
1.06A9.07