POTENTIAL TARGETS FROM HUMAN (RESULTS FROM SUB-STRUCTURAL SIMILARITY SEARCHES)
1) User may click on the DrReposER ID (the second column) to get information on the binding sites and drug molecule.
2) Click View (the second last column) to view matched residues and superposition in the NGL viewer (upper right part).
3) User may also click on the Dock (the last column) to get script for molecular docking in UCSF Chimera through AutoDock Vina.

DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SFU_A_RBVA601_1
(RNA POLYMERASE)		1lbk GLUTATHIONE
S-TRANSFERASE CLASS
PI CHIMAERA (CODA)
(Homo
sapiens)		5 / 9SER A 105
THR A 109
ASN A 110
GLY A 114
ASP A 116
None
1.46A20.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SFU_A_RBVA601_1
(RNA POLYMERASE)		2iq1 PROTEIN PHOSPHATASE
2C KAPPA, PPM1K
(Homo
sapiens)		5 / 9ASP A 109
SER A  99
THR A 327
GLY A 299
ASP A 337
 MG  A   1 ( 4.9A)
None
None
None
MG  A   1 (-3.1A)
1.40A21.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SFU_C_RBVC601_1
(RNA POLYMERASE)		1ib1 14-3-3 ZETA ISOFORM
(Homo
sapiens)		5 / 11ARG A  56
LEU A  90
LEU A  98
GLY A 123
ASP A 124
TPO  E  31 ( 3.0A)
None
None
None
None
1.32A18.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SFU_C_RBVC601_1
(RNA POLYMERASE)		2c63 14-3-3 PROTEIN ETA
(Homo
sapiens)		5 / 11ARG A  57
LEU A  93
LEU A 101
GLY A 128
ASP A 129
None
1.32A19.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SFU_C_RBVC601_1
(RNA POLYMERASE)		2iq1 PROTEIN PHOSPHATASE
2C KAPPA, PPM1K
(Homo
sapiens)		5 / 11ASP A 109
SER A  99
THR A 327
GLY A 299
ASP A 337
 MG  A   1 ( 4.9A)
None
None
None
MG  A   1 (-3.1A)
1.41A21.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SFU_C_RBVC601_1
(RNA POLYMERASE)		2uyy N-PAC PROTEIN
(Homo
sapiens)		5 / 11LEU A 277
SER A 280
ASN A 285
GLY A 397
ASP A 396
NA7  A1555 (-3.2A)
None
None
K  A1554 (-4.3A)
None
1.26A21.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SFU_C_RBVC601_1
(RNA POLYMERASE)		3ubw 14-3-3 PROTEIN
EPSILON
(Homo
sapiens)		5 / 11ARG A  57
LEU A  93
LEU A 101
GLY A 126
ASP A 127
None
None
CSO  A  98 ( 4.7A)
None
None
1.28A20.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SFU_C_RBVC601_1
(RNA POLYMERASE)		4e3c INHIBITOR OF NUCLEAR
FACTOR KAPPA-B
KINASE SUBUNIT BETA
(Homo
sapiens)		5 / 11LEU A 211
ASP A 145
LEU A 189
THR A 185
GLY A 184
None
1.44A22.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SFU_C_RBVC601_1
(RNA POLYMERASE)		5e3c DIPEPTIDYL PEPTIDASE
3
(Homo
sapiens)		5 / 11LEU A 150
SER A  53
THR A 170
THR A 169
GLY A 162
None
1.23A22.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SFU_C_RBVC601_1
(RNA POLYMERASE)		5iqp 14-3-3 PROTEIN THETA
(Homo
sapiens)		5 / 11ARG A  56
LEU A  90
LEU A  98
GLY A 123
ASP A 124
SO4  A 301 (-3.0A)
None
None
None
None
1.31A20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SFU_C_RBVC601_1
(RNA POLYMERASE)		5lu2 14-3-3 PROTEIN SIGMA
(Homo
sapiens)		5 / 11ARG A  56
LEU A  92
LEU A 100
GLY A 125
ASP A 126
None
1.43A21.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SFU_C_RBVC601_1
(RNA POLYMERASE)		5x49 PROBABLE XAA-PRO
AMINOPEPTIDASE 3
(Homo
sapiens)		5 / 11ASP A 477
SER A 489
THR A 262
GLY A 333
ASP A 342
None
None
None
None
MN  A 602 (-2.6A)
1.32A20.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SFU_C_RBVC601_1
(RNA POLYMERASE)		6byk 14-3-3 PROTEIN
BETA/ALPHA
(Homo
sapiens)		5 / 11ARG A  58
LEU A  92
LEU A 100
GLY A 125
ASP A 126
None
1.32A8.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SFU_C_RBVC601_1
(RNA POLYMERASE)		6eih 14-3-3 PROTEIN
EPSILON
(Homo
sapiens)		5 / 11ARG A  57
LEU A  93
LEU A 101
GLY A 126
ASP A 127
None
1.27A8.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SFU_C_RBVC601_1
(RNA POLYMERASE)		6fel 14-3-3 PROTEIN GAMMA
(Homo
sapiens)		5 / 11ARG A  57
LEU A  93
LEU A 101
GLY A 128
ASP A 129
None
1.30A9.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PB1_A_RBVA501_1
(NUPC FAMILY PROTEIN)		1luj CATENIN BETA-1
(Homo
sapiens)		5 / 12GLY A 277
ALA A 276
ASN A 308
SER A 311
ILE A 314
None
1.13A23.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PB1_A_RBVA501_1
(NUPC FAMILY PROTEIN)		1luj CATENIN BETA-1
(Homo
sapiens)		5 / 12GLY A 278
ALA A 276
ASN A 308
SER A 311
ILE A 314
None
1.20A23.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PB1_A_RBVA501_1
(NUPC FAMILY PROTEIN)		1zly PHOSPHORIBOSYLGLYCIN
AMIDE
FORMYLTRANSFERASE
(Homo
sapiens)		5 / 12GLY A 146
GLN A 147
ALA A 140
ASN A 194
ILE A 197
None
1.26A21.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PB1_A_RBVA501_1
(NUPC FAMILY PROTEIN)		2gy7 ANGIOPOIETIN-2
(Homo
sapiens)		5 / 12GLY A 331
GLU A 352
ASN A 470
SER A 483
ILE A 472
None
1.29A17.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PB1_A_RBVA501_1
(NUPC FAMILY PROTEIN)		2wnp FICOLIN-1
(Homo
sapiens)		5 / 12GLY F 135
GLU F 156
ASN F 273
SER F 286
ILE F 275
None
1.23A19.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PB1_A_RBVA501_1
(NUPC FAMILY PROTEIN)		2z6h CATENIN BETA-1
(Homo
sapiens)		5 / 12GLY A 277
ALA A 276
ASN A 308
SER A 311
ILE A 314
None
1.18A22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PB1_A_RBVA501_1
(NUPC FAMILY PROTEIN)		3bvh FIBRINOGEN GAMMA
CHAIN
(Homo
sapiens)		5 / 12GLY C 200
GLU C 225
ASN C 365
SER C 378
ILE C 367
None
1.21A19.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PB1_A_RBVA501_1
(NUPC FAMILY PROTEIN)		3ghg FIBRINOGEN GAMMA
CHAIN
(Homo
sapiens)		5 / 12GLY C 200
GLU C 225
ASN C 365
SER C 378
ILE C 367
GLY  C 200 ( 0.0A)
GLU  C 225 ( 0.5A)
ASN  C 365 ( 0.6A)
SER  C 378 ( 0.0A)
ILE  C 367 ( 0.5A)
1.26A19.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PB1_A_RBVA501_1
(NUPC FAMILY PROTEIN)		3ifq PLAKOGLOBIN
(Homo
sapiens)		5 / 12GLY A 269
ALA A 267
ASN A 299
SER A 302
ILE A 305
None
1.01A22.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PB1_A_RBVA501_1
(NUPC FAMILY PROTEIN)		3she MAP KINASE-ACTIVATED
PROTEIN KINASE 3
(Homo
sapiens)		5 / 12GLY A 151
ALA A 153
LEU A 183
ASN A 171
ILE A 231
None
None
None
I85  A 350 (-4.4A)
None
1.14A20.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PB1_A_RBVA501_1
(NUPC FAMILY PROTEIN)		3vd8 MALTOSE-BINDING
PERIPLASMIC PROTEIN,
INTERFERON-INDUCIBLE
PROTEIN AIM2
(Escherichia
coli;
Homo
sapiens)		5 / 12GLY A  19
GLU A  22
ALA A 292
TYR A 307
SER A 233
None
1.28A22.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PB1_A_RBVA501_1
(NUPC FAMILY PROTEIN)		4epu ANGIOPOIETIN-1
(Homo
sapiens)		5 / 12GLY A 333
GLU A 354
ASN A 472
SER A 485
ILE A 474
None
1.20A19.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PB1_A_RBVA501_1
(NUPC FAMILY PROTEIN)		4fod ALK TYROSINE KINASE
RECEPTOR
(Homo
sapiens)		5 / 12GLY A1304
ALA A1300
LEU A1291
PHE A1306
ILE A1277
None
1.28A22.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PB1_A_RBVA501_1
(NUPC FAMILY PROTEIN)		4gxb SORTING NEXIN-17
(Homo
sapiens)		5 / 12ALA A 292
LEU A 376
PHE A 274
SER A 366
ILE A 364
None
1.24A23.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PB1_A_RBVA501_1
(NUPC FAMILY PROTEIN)		4i8v CYTOCHROME P450 1A1
(Homo
sapiens)		5 / 12GLY A 316
ALA A 317
LEU A 496
SER A 120
ILE A 115
BHF  A 602 (-3.5A)
BHF  A 602 ( 3.4A)
None
BHF  A 602 ( 4.5A)
BHF  A 602 (-4.7A)
1.11A22.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PB1_A_RBVA501_1
(NUPC FAMILY PROTEIN)		4r9j FICOLIN-2
(Homo
sapiens)		5 / 12GLY G 126
GLU G 147
ASN G 264
SER G 277
ILE G 266
None
1.22A18.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PB1_A_RBVA501_1
(NUPC FAMILY PROTEIN)		5gwj DNA TOPOISOMERASE
2-BETA
(Homo
sapiens)		5 / 12GLY A 813
ALA A 816
ASN A 798
ASN A 795
SER A 794
None
None
None
MG  A1304 ( 4.8A)
None
1.36A19.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PB1_A_RBVA501_1
(NUPC FAMILY PROTEIN)		5nnz DYNEIN ASSEMBLY
FACTOR WITH WDR
REPEAT DOMAINS 1
(Homo
sapiens)		5 / 12GLY B 363
ALA B 369
ASN B 354
SER B 352
ILE B 351
None
1.25A22.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PB1_A_RBVA501_1
(NUPC FAMILY PROTEIN)		5xct VH(S112C)-SARAH
CHIMERA
VL-SARAH(S37C)CHIMER
A
(Homo
sapiens;
Mus
musculus)		5 / 12GLY A  33
GLN A  35
ALA A  32
LEU A   4
ASN B  34
None
1.24A19.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PB1_A_RBVA501_1
(NUPC FAMILY PROTEIN)		6bp2 ENVELOPE
GLYCOPROTEIN
MR191 FAB HEAVY
CHAIN
(Homo
sapiens;
Marburg
marburgvirus)		5 / 12GLY A 127
GLN A 128
TYR H  61
LEU H 110
SER H  56
None
1.19A12.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5AXD_A_RBVA502_1
(ADENOSYLHOMOCYSTEINA
SE)		2bq8 TARTRATE-RESISTANT
ACID PHOSPHATASE
TYPE 5
(Homo
sapiens)		5 / 12THR X 136
ASP X  91
ASP X  12
LEU X  86
GLY X 183
None
None
FE2  X1305 (-3.1A)
None
None
1.16A21.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5AXD_A_RBVA502_1
(ADENOSYLHOMOCYSTEINA
SE)		3h68 SERINE/THREONINE-PRO
TEIN PHOSPHATASE 5
(Homo
sapiens)		5 / 12GLU A 305
THR A 306
ASP A 271
GLY A 276
HIS A 244
None
None
ZN  A 500 (-2.8A)
None
ZN  A 501 ( 3.3A)
1.48A22.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5AXD_A_RBVA502_1
(ADENOSYLHOMOCYSTEINA
SE)		4ixu ARGINASE-2,
MITOCHONDRIAL
(Homo
sapiens)		5 / 12HIS A 145
ASP A 253
THR A 263
GLY A 161
HIS A 160
 MN  A 402 ( 3.3A)
MN  A 402 ( 2.0A)
None
38I  A 406 ( 3.7A)
38I  A 406 (-3.5A)
1.30A19.54
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5AXD_A_RBVA502_1
(ADENOSYLHOMOCYSTEINA
SE)		5w4b ADENOSYLHOMOCYSTEINA
SE
(Homo
sapiens)		5 / 12ASP A 131
LYS A 186
ASP A 190
HIS A 353
MET A 358
None
None
NAD  A 501 (-4.1A)
NAD  A 501 (-4.5A)
9W4  A 502 (-3.6A)
1.03A96.97
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5AXD_A_RBVA502_1
(ADENOSYLHOMOCYSTEINA
SE)		5w4b ADENOSYLHOMOCYSTEINA
SE
(Homo
sapiens)		5 / 12GLU A  59
ASP A 131
LYS A 186
HIS A 353
MET A 358
9W4  A 502 (-3.8A)
None
None
NAD  A 501 (-4.5A)
9W4  A 502 (-3.6A)
0.83A96.97
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5AXD_A_RBVA502_1
(ADENOSYLHOMOCYSTEINA
SE)		5w4b ADENOSYLHOMOCYSTEINA
SE
(Homo
sapiens)		7 / 12HIS A  55
THR A  57
ASP A 131
THR A 157
LYS A 186
ASP A 190
MET A 358
9W4  A 502 (-3.7A)
9W4  A 502 (-2.9A)
None
None
None
NAD  A 501 (-4.1A)
9W4  A 502 (-3.6A)
0.77A96.97
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5AXD_A_RBVA502_1
(ADENOSYLHOMOCYSTEINA
SE)		5w4b ADENOSYLHOMOCYSTEINA
SE
(Homo
sapiens)		8 / 12HIS A  55
THR A  57
GLU A  59
ASP A 131
GLU A 156
THR A 157
LYS A 186
MET A 358
9W4  A 502 (-3.7A)
9W4  A 502 (-2.9A)
9W4  A 502 (-3.8A)
None
None
None
None
9W4  A 502 (-3.6A)
0.74A96.97
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5AXD_A_RBVA502_1
(ADENOSYLHOMOCYSTEINA
SE)		5w4b ADENOSYLHOMOCYSTEINA
SE
(Homo
sapiens)		5 / 12HIS A  55
THR A  60
ASP A 131
THR A 157
ASP A 190
9W4  A 502 (-3.7A)
None
None
None
NAD  A 501 (-4.1A)
1.46A96.97
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5AXD_A_RBVA502_1
(ADENOSYLHOMOCYSTEINA
SE)		5w4b ADENOSYLHOMOCYSTEINA
SE
(Homo
sapiens)		6 / 12LYS A 186
ASP A 190
LEU A 347
GLY A 352
HIS A 353
MET A 358
None
NAD  A 501 (-4.1A)
9W4  A 502 (-4.1A)
9W4  A 502 ( 3.9A)
NAD  A 501 (-4.5A)
9W4  A 502 (-3.6A)
0.94A96.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5AXD_A_RBVA502_2
(ADENOSYLHOMOCYSTEINA
SE)		1lm5 SUBDOMAIN OF
DESMOPLAKIN
CARBOXY-TERMINAL
DOMAIN (DPCT)
(Homo
sapiens)		3 / 3THR A2733
HIS A2662
LEU A2800
None
0.77A18.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5AXD_A_RBVA502_2
(ADENOSYLHOMOCYSTEINA
SE)		1ybw HEPATOCYTE GROWTH
FACTOR ACTIVATOR
PRECURSOR
(Homo
sapiens)		3 / 3THR A 632
HIS A 438
LEU A 522
None
0.66A20.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5AXD_A_RBVA502_2
(ADENOSYLHOMOCYSTEINA
SE)		2hi9 PLASMA SERINE
PROTEASE INHIBITOR
(Homo
sapiens)		3 / 3THR A 141
HIS A 330
LEU A 168
None
0.80A21.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5AXD_A_RBVA502_2
(ADENOSYLHOMOCYSTEINA
SE)		2jsd MATRIX
METALLOPROTEINASE-20
(Homo
sapiens)		3 / 3THR A 203
HIS A 257
LEU A 243
None
0.73A19.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5AXD_A_RBVA502_2
(ADENOSYLHOMOCYSTEINA
SE)		2r0l HEPATOCYTE GROWTH
FACTOR ACTIVATOR
(Homo
sapiens)		3 / 3THR A 229
HIS A  48
LEU A 123
None
0.80A20.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5AXD_A_RBVA502_2
(ADENOSYLHOMOCYSTEINA
SE)		2zec TRYPTASE BETA 2
(Homo
sapiens)		3 / 3THR A 124
HIS A 254
LEU A 109
None
0.79A19.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5AXD_A_RBVA502_2
(ADENOSYLHOMOCYSTEINA
SE)		2zgh GRANZYME M
(Homo
sapiens)		3 / 3THR A 215
HIS A  32
LEU A 107
None
0.74A20.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5AXD_A_RBVA502_2
(ADENOSYLHOMOCYSTEINA
SE)		3gcw PROPROTEIN
CONVERTASE
SUBTILISIN/KEXIN
TYPE 9
(Homo
sapiens)		3 / 3THR A 335
HIS A 464
LEU A 436
None
0.73A21.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5AXD_A_RBVA502_2
(ADENOSYLHOMOCYSTEINA
SE)		4btm TAU-TUBULIN KINASE 1
(Homo
sapiens)		3 / 3THR A 208
HIS A 113
LEU A 108
None
0.76A21.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5AXD_A_RBVA502_2
(ADENOSYLHOMOCYSTEINA
SE)		4dy0 GLIA-DERIVED NEXIN
(Homo
sapiens)		3 / 3THR A 142
HIS A 319
LEU A 150
None
GOL  A 404 ( 4.7A)
None
0.75A20.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5AXD_A_RBVA502_2
(ADENOSYLHOMOCYSTEINA
SE)		4nfn TAU-TUBULIN KINASE 1
(Homo
sapiens)		3 / 3THR A 184
HIS A  89
LEU A  84
None
0.80A21.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5AXD_A_RBVA502_2
(ADENOSYLHOMOCYSTEINA
SE)		4o3m BLOOM SYNDROME
PROTEIN
(Homo
sapiens)		3 / 3THR A 999
HIS A1091
LEU A1114
None
0.61A22.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5AXD_A_RBVA502_2
(ADENOSYLHOMOCYSTEINA
SE)		5dgo CELL DIVISION
CONTROL PROTEIN 45
HOMOLOG
(Homo
sapiens)		3 / 3THR A 225
HIS A 369
LEU A 412
None
None
EDO  A 601 ( 4.2A)
0.79A21.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5AXD_A_RBVA502_2
(ADENOSYLHOMOCYSTEINA
SE)		5kca CEREBELLIN-1,CEREBEL
LIN-1,CEREBELLIN-1,G
LUTAMATE RECEPTOR
IONOTROPIC, DELTA-2
(Homo
sapiens)		3 / 3THR A 212
HIS A 599
LEU A 839
None
0.57A18.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5AXD_A_RBVA502_2
(ADENOSYLHOMOCYSTEINA
SE)		6f9n CLEAVAGE AND
POLYADENYLATION
SPECIFICITY FACTOR
SUBUNIT 1
(Homo
sapiens)		3 / 3THR A 266
HIS A1068
LEU A 303
None
0.82A11.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5AXD_C_RBVC502_1
(ADENOSYLHOMOCYSTEINA
SE)		3h68 SERINE/THREONINE-PRO
TEIN PHOSPHATASE 5
(Homo
sapiens)		5 / 12GLU A 305
THR A 306
ASP A 271
GLY A 276
HIS A 244
None
None
ZN  A 500 (-2.8A)
None
ZN  A 501 ( 3.3A)
1.48A22.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5AXD_C_RBVC502_1
(ADENOSYLHOMOCYSTEINA
SE)		4ixu ARGINASE-2,
MITOCHONDRIAL
(Homo
sapiens)		5 / 12HIS A 145
ASP A 253
THR A 263
GLY A 161
HIS A 160
 MN  A 402 ( 3.3A)
MN  A 402 ( 2.0A)
None
38I  A 406 ( 3.7A)
38I  A 406 (-3.5A)
1.30A19.54
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5AXD_C_RBVC502_1
(ADENOSYLHOMOCYSTEINA
SE)		5w4b ADENOSYLHOMOCYSTEINA
SE
(Homo
sapiens)		5 / 12ASP A 131
LYS A 186
ASP A 190
HIS A 353
MET A 358
None
None
NAD  A 501 (-4.1A)
NAD  A 501 (-4.5A)
9W4  A 502 (-3.6A)
1.03A96.97
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5AXD_C_RBVC502_1
(ADENOSYLHOMOCYSTEINA
SE)		5w4b ADENOSYLHOMOCYSTEINA
SE
(Homo
sapiens)		5 / 12GLU A  59
ASP A 131
LYS A 186
HIS A 353
MET A 358
9W4  A 502 (-3.8A)
None
None
NAD  A 501 (-4.5A)
9W4  A 502 (-3.6A)
0.80A96.97
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5AXD_C_RBVC502_1
(ADENOSYLHOMOCYSTEINA
SE)		5w4b ADENOSYLHOMOCYSTEINA
SE
(Homo
sapiens)		7 / 12HIS A  55
THR A  57
ASP A 131
THR A 157
LYS A 186
ASP A 190
MET A 358
9W4  A 502 (-3.7A)
9W4  A 502 (-2.9A)
None
None
None
NAD  A 501 (-4.1A)
9W4  A 502 (-3.6A)
0.77A96.97
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5AXD_C_RBVC502_1
(ADENOSYLHOMOCYSTEINA
SE)		5w4b ADENOSYLHOMOCYSTEINA
SE
(Homo
sapiens)		8 / 12HIS A  55
THR A  57
GLU A  59
ASP A 131
GLU A 156
THR A 157
LYS A 186
MET A 358
9W4  A 502 (-3.7A)
9W4  A 502 (-2.9A)
9W4  A 502 (-3.8A)
None
None
None
None
9W4  A 502 (-3.6A)
0.73A96.97
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5AXD_C_RBVC502_1
(ADENOSYLHOMOCYSTEINA
SE)		5w4b ADENOSYLHOMOCYSTEINA
SE
(Homo
sapiens)		5 / 12HIS A  55
THR A  60
ASP A 131
THR A 157
ASP A 190
9W4  A 502 (-3.7A)
None
None
None
NAD  A 501 (-4.1A)
1.47A96.97
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5AXD_C_RBVC502_1
(ADENOSYLHOMOCYSTEINA
SE)		5w4b ADENOSYLHOMOCYSTEINA
SE
(Homo
sapiens)		6 / 12LYS A 186
ASP A 190
LEU A 347
GLY A 352
HIS A 353
MET A 358
None
NAD  A 501 (-4.1A)
9W4  A 502 (-4.1A)
9W4  A 502 ( 3.9A)
NAD  A 501 (-4.5A)
9W4  A 502 (-3.6A)
0.95A96.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5AXD_C_RBVC502_2
(ADENOSYLHOMOCYSTEINA
SE)		1dgv APO CIB
(Homo
sapiens)		3 / 3THR A  93
HIS A  23
LEU A  84
None
0.83A17.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5AXD_C_RBVC502_2
(ADENOSYLHOMOCYSTEINA
SE)		1fuj PR3
(Homo
sapiens)		3 / 3THR A 229
HIS A  48
LEU A 123
None
0.83A19.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5AXD_C_RBVC502_2
(ADENOSYLHOMOCYSTEINA
SE)		1i51 CASPASE-7 SUBUNIT
P11
X-LINKED INHIBITOR
OF APOPTOSIS PROTEIN
(Homo
sapiens)		3 / 3THR B 225
HIS B 281
LEU E 141
None
0.87A13.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5AXD_C_RBVC502_2
(ADENOSYLHOMOCYSTEINA
SE)		1lm5 SUBDOMAIN OF
DESMOPLAKIN
CARBOXY-TERMINAL
DOMAIN (DPCT)
(Homo
sapiens)		3 / 3THR A2733
HIS A2662
LEU A2800
None
0.81A18.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5AXD_C_RBVC502_2
(ADENOSYLHOMOCYSTEINA
SE)		1qmn ALPHA-1-ANTICHYMOTRY
PSIN
(Homo
sapiens)		3 / 3THR A 238
HIS A 224
LEU A 226
None
0.85A21.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5AXD_C_RBVC502_2
(ADENOSYLHOMOCYSTEINA
SE)		1sl6 C-TYPE LECTIN
DC-SIGNR
(Homo
sapiens)		3 / 3THR A 319
HIS A 290
LEU A 303
None
0.87A18.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5AXD_C_RBVC502_2
(ADENOSYLHOMOCYSTEINA
SE)		1ybw HEPATOCYTE GROWTH
FACTOR ACTIVATOR
PRECURSOR
(Homo
sapiens)		3 / 3THR A 632
HIS A 438
LEU A 522
None
0.65A20.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5AXD_C_RBVC502_2
(ADENOSYLHOMOCYSTEINA
SE)		2a24 ENDOTHELIAL PAS
DOMAIN PROTEIN 1
(Homo
sapiens)		3 / 3THR A  85
HIS A  32
LEU A  36
None
0.88A14.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5AXD_C_RBVC502_2
(ADENOSYLHOMOCYSTEINA
SE)		2hi9 PLASMA SERINE
PROTEASE INHIBITOR
(Homo
sapiens)		3 / 3THR A 141
HIS A 330
LEU A 168
None
0.80A21.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5AXD_C_RBVC502_2
(ADENOSYLHOMOCYSTEINA
SE)		2j0u ATP-DEPENDENT RNA
HELICASE DDX48
(Homo
sapiens)		3 / 3THR A 212
HIS A 138
LEU A 176
None
0.81A21.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5AXD_C_RBVC502_2
(ADENOSYLHOMOCYSTEINA
SE)		2jsd MATRIX
METALLOPROTEINASE-20
(Homo
sapiens)		3 / 3THR A 203
HIS A 257
LEU A 243
None
0.71A19.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5AXD_C_RBVC502_2
(ADENOSYLHOMOCYSTEINA
SE)		2p9r ALPHA-2-MACROGLOBULI
N
(Homo
sapiens)		3 / 3THR A 192
HIS A 133
LEU A 135
None
0.86A11.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5AXD_C_RBVC502_2
(ADENOSYLHOMOCYSTEINA
SE)		2r0l HEPATOCYTE GROWTH
FACTOR ACTIVATOR
(Homo
sapiens)		3 / 3THR A 229
HIS A  48
LEU A 123
None
0.79A20.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5AXD_C_RBVC502_2
(ADENOSYLHOMOCYSTEINA
SE)		2ytu FRIEND LEUKEMIA
INTEGRATION 1
TRANSCRIPTION FACTOR
(Homo
sapiens)		3 / 3THR A  87
HIS A  45
LEU A  75
None
0.79A13.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5AXD_C_RBVC502_2
(ADENOSYLHOMOCYSTEINA
SE)		2zec TRYPTASE BETA 2
(Homo
sapiens)		3 / 3THR A 124
HIS A 254
LEU A 109
None
0.80A19.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5AXD_C_RBVC502_2
(ADENOSYLHOMOCYSTEINA
SE)		2zgh GRANZYME M
(Homo
sapiens)		3 / 3THR A 215
HIS A  32
LEU A 107
None
0.75A20.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5AXD_C_RBVC502_2
(ADENOSYLHOMOCYSTEINA
SE)		2zu6 EUKARYOTIC
INITIATION FACTOR
4A-I
(Homo
sapiens)		3 / 3THR A 207
HIS A 132
LEU A 171
None
0.85A22.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5AXD_C_RBVC502_2
(ADENOSYLHOMOCYSTEINA
SE)		3f6u VITAMIN K-DEPENDENT
PROTEIN C HEAVY
CHAIN
(Homo
sapiens)		3 / 3THR H 229
HIS H  48
LEU H 123
None
0.85A20.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5AXD_C_RBVC502_2
(ADENOSYLHOMOCYSTEINA
SE)		3fjo NADPH-CYTOCHROME
P450 REDUCTASE
(Homo
sapiens;
Saccharomyces
cerevisiae)		3 / 3THR A 231
HIS A 423
LEU A 328
None
0.76A21.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5AXD_C_RBVC502_2
(ADENOSYLHOMOCYSTEINA
SE)		3gcw PROPROTEIN
CONVERTASE
SUBTILISIN/KEXIN
TYPE 9
(Homo
sapiens)		3 / 3THR A 335
HIS A 464
LEU A 436
None
0.74A21.10