POTENTIAL TARGETS FROM HUMAN (RESULTS FROM SUB-STRUCTURAL SIMILARITY SEARCHES)
1) User may click on the DrReposER ID (the second column) to get information on the binding sites and drug molecule.
2) Click View (the second last column) to view matched residues and superposition in the NGL viewer (upper right part).
3) User may also click on the Dock (the last column) to get script for molecular docking in UCSF Chimera through AutoDock Vina.

DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DED_A_QPSA1001_1
(CYCLODEXTRIN
GLUCANOTRANSFERASE)		1jxk ALPHA-AMYLASE,
SALIVARY
(Homo
sapiens)		7 / 12TYR A  62
LEU A 162
LEU A 165
ASP A 197
ALA A 198
HIS A 299
ASP A 300
None
0.71A24.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DED_A_QPSA2001_1
(CYCLODEXTRIN
GLUCANOTRANSFERASE)		1i71 APOLIPOPROTEIN(A)
(Homo
sapiens)		4 / 6TRP A  25
GLY A  43
ASN A  52
PRO A  41
None
1.27A9.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DED_A_QPSA2001_1
(CYCLODEXTRIN
GLUCANOTRANSFERASE)		2f15 5'-AMP-ACTIVATED
PROTEIN KINASE,
BETA-2 SUBUNIT
(Homo
sapiens)		4 / 6TRP A  99
LYS A 126
TRP A 133
ASN A 150
None
0.67A9.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DED_A_QPSA2001_1
(CYCLODEXTRIN
GLUCANOTRANSFERASE)		2gy7 ANGIOPOIETIN-2
(Homo
sapiens)		4 / 6TRP A 354
TRP A 446
ASN A 456
PRO A 452
None
1.12A14.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DED_A_QPSA2001_1
(CYCLODEXTRIN
GLUCANOTRANSFERASE)		2vc2 INTEGRIN ALPHA-IIB
(Homo
sapiens)		4 / 6TRP A 262
GLY A 233
ASN A 227
PRO A 258
None
1.44A20.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DED_A_QPSA2001_1
(CYCLODEXTRIN
GLUCANOTRANSFERASE)		3whe HEMAGGLUTININ
IMMUNOGLOBULIN HEAVY
CHAIN
(Homo
sapiens;
Influenza
A
virus)		4 / 6TRP M  50
GLY M 104
ASN M  52
PRO A 284
None
NAG  A 601 (-3.6A)
None
None
1.38A15.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DED_A_QPSA2001_1
(CYCLODEXTRIN
GLUCANOTRANSFERASE)		4bvw APOLIPOPROTEIN(A)
(Homo
sapiens)		4 / 6TRP A  25
GLY A  43
ASN A  52
PRO A  41
None
1.29A9.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DED_A_QPSA2001_1
(CYCLODEXTRIN
GLUCANOTRANSFERASE)		4epu ANGIOPOIETIN-1
(Homo
sapiens)		4 / 6TRP A 356
TRP A 448
ASN A 458
PRO A 454
None
1.21A16.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DED_A_QPSA2001_1
(CYCLODEXTRIN
GLUCANOTRANSFERASE)		4rkk LAFORIN
(Homo
sapiens)		4 / 6TRP A  32
LYS A  87
TRP A  99
GLY A 101
GLC  A 417 ( 3.7A)
GLC  A 414 (-2.7A)
GLC  A 414 (-3.9A)
None
0.48A18.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DED_B_QPSB1501_1
(CYCLODEXTRIN
GLUCANOTRANSFERASE)		1jxk ALPHA-AMYLASE,
SALIVARY
(Homo
sapiens)		8 / 12TYR A  62
LEU A 165
ARG A 195
ASP A 197
ALA A 198
GLU A 233
HIS A 299
ASP A 300
None
None
CL  A 493 (-4.0A)
None
None
None
None
None
0.80A24.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X2I_A_QPSA1050_1
(ALPHA-1,4-GLUCAN
LYASE ISOZYME 1)		3ctt MALTASE-GLUCOAMYLASE
(Homo
sapiens)		6 / 12ASP A 203
ASP A 327
ASP A 443
ASP A 542
PHE A 575
HIS A 600
GOL  A3001 (-2.6A)
3CU  A1001 (-2.7A)
3CU  A1001 (-2.7A)
3CU  A1001 ( 2.5A)
3CU  A1001 (-4.5A)
3CU  A1001 (-3.9A)
0.51A24.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X2I_A_QPSA1050_1
(ALPHA-1,4-GLUCAN
LYASE ISOZYME 1)		3lpp SUCRASE-ISOMALTASE
(Homo
sapiens)		7 / 12ASP A 231
GLN A 232
ASP A 355
ASP A 472
ASP A 571
PHE A 604
HIS A 629
None
None
TRS  A6001 (-2.9A)
TRS  A6001 (-3.2A)
TRS  A6001 ( 3.7A)
TRS  A6001 (-4.4A)
TRS  A6001 (-4.2A)
0.72A23.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X2I_A_QPSA1050_1
(ALPHA-1,4-GLUCAN
LYASE ISOZYME 1)		3lpp SUCRASE-ISOMALTASE
(Homo
sapiens)		6 / 12LEU A 233
GLN A 232
ASP A 355
ASP A 571
PHE A 604
HIS A 629
None
None
TRS  A6001 (-2.9A)
TRS  A6001 ( 3.7A)
TRS  A6001 (-4.4A)
TRS  A6001 (-4.2A)
0.93A23.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X2I_A_QPSA1050_1
(ALPHA-1,4-GLUCAN
LYASE ISOZYME 1)		3top MALTASE-GLUCOAMYLASE
, INTESTINAL
(Homo
sapiens)		7 / 12ASP A1157
GLN A1158
ASP A1279
ASP A1420
ASP A1526
PHE A1559
HIS A1584
ACR  A   1 (-2.6A)
ACR  A   1 ( 4.8A)
ACR  A   1 (-3.2A)
ACR  A   1 (-3.6A)
ACR  A   1 (-2.8A)
ACR  A   1 (-4.3A)
ACR  A   1 (-3.9A)
1.00A24.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X2I_A_QPSA1050_1
(ALPHA-1,4-GLUCAN
LYASE ISOZYME 1)		5nn8 LYSOSOMAL
ALPHA-GLUCOSIDASE
(Homo
sapiens)		6 / 12ASP A 282
ASP A 404
ASP A 518
ASP A 616
PHE A 649
HIS A 674
ACR  A1015 (-2.6A)
ACR  A1015 (-3.0A)
ACR  A1015 (-3.1A)
ACR  A1015 (-2.7A)
ACR  A1015 (-4.3A)
ACR  A1015 (-4.0A)
0.54A24.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X2I_A_QPSA1050_1
(ALPHA-1,4-GLUCAN
LYASE ISOZYME 1)		5yz0 SERINE/THREONINE-PRO
TEIN KINASE ATR
(Homo
sapiens)		5 / 12ASP A2330
LEU A2332
ASN A2480
ASP A2494
ASP A2335
None
1.44A5.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X2I_A_QPSA1050_2
(ALPHA-1,4-GLUCAN
LYASE ISOZYME 1)		1lt8 BETAINE-HOMOCYSTEINE
METHYLTRANSFERASE
(Homo
sapiens)		4 / 6VAL A 343
TRP A 352
ARG A 278
TRP A 279
None
1.17A16.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X2I_A_QPSA1050_2
(ALPHA-1,4-GLUCAN
LYASE ISOZYME 1)		3ctt MALTASE-GLUCOAMYLASE
(Homo
sapiens)		4 / 6TRP A 441
MET A 444
ARG A 526
TRP A 539
3CU  A1001 (-4.9A)
3CU  A1001 ( 3.9A)
3CU  A1001 ( 3.5A)
3CU  A1001 (-4.6A)
0.52A24.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X2I_A_QPSA1050_2
(ALPHA-1,4-GLUCAN
LYASE ISOZYME 1)		3lpp SUCRASE-ISOMALTASE
(Homo
sapiens)		4 / 6TRP A 470
MET A 473
ARG A 555
TRP A 568
None
TRS  A6001 ( 3.7A)
TRS  A6001 ( 4.6A)
None
0.62A23.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X2I_A_QPSA1050_2
(ALPHA-1,4-GLUCAN
LYASE ISOZYME 1)		3top MALTASE-GLUCOAMYLASE
, INTESTINAL
(Homo
sapiens)		4 / 6MET A1421
ARG A1510
TRP A1523
THR A1586
ACR  A   1 (-3.5A)
ACR  A   1 (-2.9A)
ACR  A   1 (-4.5A)
None
0.85A24.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X2I_A_QPSA1050_2
(ALPHA-1,4-GLUCAN
LYASE ISOZYME 1)		3top MALTASE-GLUCOAMYLASE
, INTESTINAL
(Homo
sapiens)		4 / 6TRP A1418
MET A1421
ARG A1510
TRP A1523
None
ACR  A   1 (-3.5A)
ACR  A   1 (-2.9A)
ACR  A   1 (-4.5A)
0.58A24.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X2I_A_QPSA1050_2
(ALPHA-1,4-GLUCAN
LYASE ISOZYME 1)		4e3c INHIBITOR OF NUCLEAR
FACTOR KAPPA-B
KINASE SUBUNIT BETA
(Homo
sapiens)		4 / 6VAL A 235
TRP A 206
ARG A 220
THR A 217
None
1.47A20.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X2I_A_QPSA1050_2
(ALPHA-1,4-GLUCAN
LYASE ISOZYME 1)		4nik SINGLE-CHAIN FV
FRAGMENT ANTIBODY
(Homo
sapiens)		4 / 6TRP B  38
MET B  36
ARG B  74
THR B  78
None
1.44A13.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X2I_A_QPSA1050_2
(ALPHA-1,4-GLUCAN
LYASE ISOZYME 1)		5nn8 LYSOSOMAL
ALPHA-GLUCOSIDASE
(Homo
sapiens)		4 / 6TRP A 516
MET A 519
ARG A 600
TRP A 613
None
ACR  A1015 (-3.3A)
ACR  A1015 (-3.1A)
ACR  A1015 (-4.8A)
0.44A24.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X2I_A_QPSA1050_2
(ALPHA-1,4-GLUCAN
LYASE ISOZYME 1)		5y3r DNA-DEPENDENT
PROTEIN KINASE
CATALYTIC SUBUNIT
(Homo
sapiens)		4 / 6VAL C3726
ARG C3630
TRP C3686
THR C3635
None
1.45A12.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X2I_A_QPSA1060_1
(ALPHA-1,4-GLUCAN
LYASE ISOZYME 1)		2kzt PROGRAMMED CELL
DEATH PROTEIN 4
(Homo
sapiens)		5 / 12THR A 277
ASN A 276
VAL A 269
GLY A 270
ALA A 266
None
0.99A9.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X2I_A_QPSA1060_1
(ALPHA-1,4-GLUCAN
LYASE ISOZYME 1)		2m2b RNA-BINDING PROTEIN
10
(Homo
sapiens)		5 / 12SER A  39
THR A  99
ASN A  30
GLY A  68
ALA A  70
None
1.05A8.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X2I_A_QPSA1060_1
(ALPHA-1,4-GLUCAN
LYASE ISOZYME 1)		2xzo REGULATOR OF
NONSENSE TRANSCRIPTS
1
(Homo
sapiens)		5 / 12VAL A 310
SER A 419
THR A 616
VAL A 648
ALA A 426
None
U  D   5 ( 3.5A)
U  D   6 ( 2.8A)
1PE  A1003 ( 4.0A)
1PE  A1003 (-3.6A)
1.25A20.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X2I_A_QPSA1060_1
(ALPHA-1,4-GLUCAN
LYASE ISOZYME 1)		3kvo HYDROXYSTEROID
DEHYDROGENASE-LIKE
PROTEIN 2
(Homo
sapiens)		5 / 12PHE A  14
SER A 133
THR A 129
GLY A  17
ALA A  40
None
None
None
NAP  A 501 (-3.3A)
None
1.05A15.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X2I_A_QPSA1060_1
(ALPHA-1,4-GLUCAN
LYASE ISOZYME 1)		4chb KELCH-LIKE PROTEIN 2
(Homo
sapiens)		5 / 12VAL A 509
SER A 487
SER A 439
THR A 392
GLY A 550
None
1.24A15.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X2I_A_QPSA1060_1
(ALPHA-1,4-GLUCAN
LYASE ISOZYME 1)		4fc7 PEROXISOMAL
2,4-DIENOYL-COA
REDUCTASE
(Homo
sapiens)		5 / 12PHE A  32
SER A 145
THR A 141
GLY A  35
ALA A  58
None
None
None
NAP  A 401 (-3.5A)
None
1.13A14.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X2I_A_QPSA1060_1
(ALPHA-1,4-GLUCAN
LYASE ISOZYME 1)		4l1m E3 UBIQUITIN-PROTEIN
LIGASE HERC2
(Homo
sapiens)		5 / 12PHE A 463
SER A 479
THR A 481
TRP A 433
GLY A 447
None
UNX  A 807 ( 3.1A)
None
None
None
1.23A16.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X2I_A_QPSA1060_1
(ALPHA-1,4-GLUCAN
LYASE ISOZYME 1)		4ydk HEAVY CHAIN OF
ANTIBODY
C38-VRC16.01
LIGHT CHAIN OF
ANTIBODY
C38-VRC16.01
(Homo
sapiens)		5 / 12PHE H  97
SER L  91
VAL H  50
GLY H  35
ALA H  33
GOL  H 303 (-4.4A)
None
None
None
None
1.12A13.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X2I_A_QPSA1060_1
(ALPHA-1,4-GLUCAN
LYASE ISOZYME 1)		4ztu DNA POLYMERASE
SUBUNIT GAMMA-2,
MITOCHONDRIAL
(Homo
sapiens)		5 / 12VAL B 338
SER B 117
VAL B 125
GLY B 207
ALA B 209
None
1.23A17.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X2I_A_QPSA1060_1
(ALPHA-1,4-GLUCAN
LYASE ISOZYME 1)		5c53 POL GAMMA B
(Homo
sapiens)		5 / 12VAL B 338
SER B 117
VAL B 125
GLY B 207
ALA B 209
None
1.24A20.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X2I_A_QPSA1060_1
(ALPHA-1,4-GLUCAN
LYASE ISOZYME 1)		5gwj DNA TOPOISOMERASE
2-BETA
(Homo
sapiens)		5 / 12THR A 808
ASN A 786
GLY A 813
ALA A 816
GLN A 805
None
MG  A1304 ( 4.8A)
None
None
None
1.19A21.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X2I_A_QPSA1060_1
(ALPHA-1,4-GLUCAN
LYASE ISOZYME 1)		5iz5 CYTOSOLIC
PHOSPHOLIPASE A2
DELTA
(Homo
sapiens)		5 / 12VAL B 354
PHE B 357
SER B 358
SER B 655
THR B 654
None
1.13A22.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X2I_B_QPSB1050_1
(ALPHA-1,4-GLUCAN
LYASE ISOZYME 1)		3ctt MALTASE-GLUCOAMYLASE
(Homo
sapiens)		7 / 12ASP A 203
ASP A 327
ASP A 443
MET A 444
ASP A 542
PHE A 575
HIS A 600
GOL  A3001 (-2.6A)
3CU  A1001 (-2.7A)
3CU  A1001 (-2.7A)
3CU  A1001 ( 3.9A)
3CU  A1001 ( 2.5A)
3CU  A1001 (-4.5A)
3CU  A1001 (-3.9A)
0.60A24.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X2I_B_QPSB1050_1
(ALPHA-1,4-GLUCAN
LYASE ISOZYME 1)		3lpp SUCRASE-ISOMALTASE
(Homo
sapiens)		8 / 12ASP A 231
GLN A 232
ASP A 355
ASP A 472
MET A 473
ASP A 571
PHE A 604
HIS A 629
None
None
TRS  A6001 (-2.9A)
TRS  A6001 (-3.2A)
TRS  A6001 ( 3.7A)
TRS  A6001 ( 3.7A)
TRS  A6001 (-4.4A)
TRS  A6001 (-4.2A)
0.69A23.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X2I_B_QPSB1050_1
(ALPHA-1,4-GLUCAN
LYASE ISOZYME 1)		3lpp SUCRASE-ISOMALTASE
(Homo
sapiens)		7 / 12LEU A 233
GLN A 232
ASP A 355
ASP A 472
ASP A 571
PHE A 604
HIS A 629
None
None
TRS  A6001 (-2.9A)
TRS  A6001 (-3.2A)
TRS  A6001 ( 3.7A)
TRS  A6001 (-4.4A)
TRS  A6001 (-4.2A)
0.76A23.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X2I_B_QPSB1050_1
(ALPHA-1,4-GLUCAN
LYASE ISOZYME 1)		3top MALTASE-GLUCOAMYLASE
, INTESTINAL
(Homo
sapiens)		8 / 12ASP A1157
GLN A1158
ASP A1279
ASP A1420
MET A1421
ASP A1526
PHE A1559
HIS A1584
ACR  A   1 (-2.6A)
ACR  A   1 ( 4.8A)
ACR  A   1 (-3.2A)
ACR  A   1 (-3.6A)
ACR  A   1 (-3.5A)
ACR  A   1 (-2.8A)
ACR  A   1 (-4.3A)
ACR  A   1 (-3.9A)
0.96A24.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X2I_B_QPSB1050_1
(ALPHA-1,4-GLUCAN
LYASE ISOZYME 1)		5dsy POLY [ADP-RIBOSE]
POLYMERASE 2
(Homo
sapiens)		5 / 12GLN A 371
ASN A 544
ASP A 452
MET A 453
PHE A 515
None
1.41A14.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X2I_B_QPSB1050_1
(ALPHA-1,4-GLUCAN
LYASE ISOZYME 1)		5nn8 LYSOSOMAL
ALPHA-GLUCOSIDASE
(Homo
sapiens)		7 / 12ASP A 282
ASP A 404
ASP A 518
MET A 519
ASP A 616
PHE A 649
HIS A 674
ACR  A1015 (-2.6A)
ACR  A1015 (-3.0A)
ACR  A1015 (-3.1A)
ACR  A1015 (-3.3A)
ACR  A1015 (-2.7A)
ACR  A1015 (-4.3A)
ACR  A1015 (-4.0A)
0.62A24.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X2I_B_QPSB1050_1
(ALPHA-1,4-GLUCAN
LYASE ISOZYME 1)		5yz0 SERINE/THREONINE-PRO
TEIN KINASE ATR
(Homo
sapiens)		5 / 12ASP A2330
LEU A2332
ASN A2480
ASP A2494
ASP A2335
None
1.47A5.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X2I_B_QPSB1050_2
(ALPHA-1,4-GLUCAN
LYASE ISOZYME 1)		3top MALTASE-GLUCOAMYLASE
, INTESTINAL
(Homo
sapiens)		4 / 6TRP A1418
ARG A1510
TRP A1523
THR A1586
None
ACR  A   1 (-2.9A)
ACR  A   1 (-4.5A)
None
1.04A24.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X2I_B_QPSB1050_2
(ALPHA-1,4-GLUCAN
LYASE ISOZYME 1)		5m7r PROTEIN O-GLCNACASE
(Homo
sapiens)		4 / 6PHE A 164
TYR A 111
ARG A  78
THR A 121
None
1.17A21.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X2I_B_QPSB1060_1
(ALPHA-1,4-GLUCAN
LYASE ISOZYME 1)		1dtd CARBOXYPEPTIDASE A2
(Homo
sapiens)		5 / 10VAL A 536
SER A 614
SER A 622
GLY A 608
ALA A 505
None
1.29A13.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X2I_B_QPSB1060_1
(ALPHA-1,4-GLUCAN
LYASE ISOZYME 1)		1glo CATHEPSIN S
(Homo
sapiens)		5 / 10PHE A  28
ASN A  63
GLY A  68
ALA A  24
GLN A  19
None
1.30A12.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X2I_B_QPSB1060_1
(ALPHA-1,4-GLUCAN
LYASE ISOZYME 1)		1glo CATHEPSIN S
(Homo
sapiens)		5 / 10SER A  29
SER A 135
GLY A  68
ALA A  24
GLN A  19
None
1.49A12.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X2I_B_QPSB1060_1
(ALPHA-1,4-GLUCAN
LYASE ISOZYME 1)		2c0y PROCATHEPSIN S
(Homo
sapiens)		5 / 10PHE A 127
ASN A 162
GLY A 167
ALA A 123
GLN A 118
None
1.39A16.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X2I_B_QPSB1060_1
(ALPHA-1,4-GLUCAN
LYASE ISOZYME 1)		2wnp FICOLIN-1
(Homo
sapiens)		5 / 10SER F 218
SER F 278
TRP F 277
GLY F 213
ALA F 189
None
1.29A13.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X2I_B_QPSB1060_1
(ALPHA-1,4-GLUCAN
LYASE ISOZYME 1)		5ir3 IG LAMBDA CHAIN V-VI
REGION AR
(Homo
sapiens)		5 / 10PHE A  20
SER A  75
SER A  66
TRP A  36
GLY A 103
None
1.38A8.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X2I_C_QPSC1050_1
(ALPHA-1,4-GLUCAN
LYASE ISOZYME 1)		3ctt MALTASE-GLUCOAMYLASE
(Homo
sapiens)		7 / 12ASP A 203
ASP A 327
ASP A 443
MET A 444
ASP A 542
PHE A 575
HIS A 600
GOL  A3001 (-2.6A)
3CU  A1001 (-2.7A)
3CU  A1001 (-2.7A)
3CU  A1001 ( 3.9A)
3CU  A1001 ( 2.5A)
3CU  A1001 (-4.5A)
3CU  A1001 (-3.9A)
0.52A24.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X2I_C_QPSC1050_1
(ALPHA-1,4-GLUCAN
LYASE ISOZYME 1)		3lpp SUCRASE-ISOMALTASE
(Homo
sapiens)		8 / 12ASP A 231
GLN A 232
ASP A 355
ASP A 472
MET A 473
ASP A 571
PHE A 604
HIS A 629
None
None
TRS  A6001 (-2.9A)
TRS  A6001 (-3.2A)
TRS  A6001 ( 3.7A)
TRS  A6001 ( 3.7A)
TRS  A6001 (-4.4A)
TRS  A6001 (-4.2A)
0.70A23.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X2I_C_QPSC1050_1
(ALPHA-1,4-GLUCAN
LYASE ISOZYME 1)		3top MALTASE-GLUCOAMYLASE
, INTESTINAL
(Homo
sapiens)		8 / 12ASP A1157
GLN A1158
ASP A1279
ASP A1420
MET A1421
ASP A1526
PHE A1559
HIS A1584
ACR  A   1 (-2.6A)
ACR  A   1 ( 4.8A)
ACR  A   1 (-3.2A)
ACR  A   1 (-3.6A)
ACR  A   1 (-3.5A)
ACR  A   1 (-2.8A)
ACR  A   1 (-4.3A)
ACR  A   1 (-3.9A)
0.97A24.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X2I_C_QPSC1050_1
(ALPHA-1,4-GLUCAN
LYASE ISOZYME 1)		5dsy POLY [ADP-RIBOSE]
POLYMERASE 2
(Homo
sapiens)		5 / 12GLN A 371
ASN A 544
ASP A 452
MET A 453
PHE A 515
None
1.42A14.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X2I_C_QPSC1050_1
(ALPHA-1,4-GLUCAN
LYASE ISOZYME 1)		5nn8 LYSOSOMAL
ALPHA-GLUCOSIDASE
(Homo
sapiens)		7 / 12ASP A 282
ASP A 404
ASP A 518
MET A 519
ASP A 616
PHE A 649
HIS A 674
ACR  A1015 (-2.6A)
ACR  A1015 (-3.0A)
ACR  A1015 (-3.1A)
ACR  A1015 (-3.3A)
ACR  A1015 (-2.7A)
ACR  A1015 (-4.3A)
ACR  A1015 (-4.0A)
0.53A24.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X2I_C_QPSC1050_2
(ALPHA-1,4-GLUCAN
LYASE ISOZYME 1)		3lpp SUCRASE-ISOMALTASE
(Homo
sapiens)		4 / 5LEU A 233
TRP A 470
ARG A 555
TRP A 568
None
None
TRS  A6001 ( 4.6A)
None
0.84A23.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X2I_C_QPSC1060_1
(ALPHA-1,4-GLUCAN
LYASE ISOZYME 1)		1so8 3-HYDROXYACYL-COA
DEHYDROGENASE TYPE
II
(Homo
sapiens)		5 / 12THR A  66
SER A 155
THR A 195
ASN A 152
ALA A  92
None
CL  A 303 (-4.8A)
None
None
None
1.28A13.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X2I_C_QPSC1060_1
(ALPHA-1,4-GLUCAN
LYASE ISOZYME 1)		2kzt PROGRAMMED CELL
DEATH PROTEIN 4
(Homo
sapiens)		5 / 12THR A 277
ASN A 276
VAL A 269
GLY A 270
ALA A 266
None
0.99A9.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X2I_C_QPSC1060_1
(ALPHA-1,4-GLUCAN
LYASE ISOZYME 1)		2m2b RNA-BINDING PROTEIN
10
(Homo
sapiens)		5 / 12SER A  39
THR A  99
ASN A  30
GLY A  68
ALA A  70
None
1.04A8.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X2I_C_QPSC1060_1
(ALPHA-1,4-GLUCAN
LYASE ISOZYME 1)		2xzo REGULATOR OF
NONSENSE TRANSCRIPTS
1
(Homo
sapiens)		5 / 12VAL A 310
SER A 419
THR A 616
VAL A 648
ALA A 426
None
U  D   5 ( 3.5A)
U  D   6 ( 2.8A)
1PE  A1003 ( 4.0A)
1PE  A1003 (-3.6A)
1.27A20.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X2I_C_QPSC1060_1
(ALPHA-1,4-GLUCAN
LYASE ISOZYME 1)		4ydk HEAVY CHAIN OF
ANTIBODY
C38-VRC16.01
LIGHT CHAIN OF
ANTIBODY
C38-VRC16.01
(Homo
sapiens)		5 / 12PHE H  97
SER L  91
VAL H  50
GLY H  35
ALA H  33
GOL  H 303 (-4.4A)
None
None
None
None
1.20A13.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X2I_C_QPSC1060_1
(ALPHA-1,4-GLUCAN
LYASE ISOZYME 1)		5iz5 CYTOSOLIC
PHOSPHOLIPASE A2
DELTA
(Homo
sapiens)		5 / 12VAL B 354
PHE B 357
SER B 358
SER B 655
THR B 654
None
1.11A22.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X2I_D_QPSD1050_1
(ALPHA-1,4-GLUCAN
LYASE ISOZYME 1)		3ctt MALTASE-GLUCOAMYLASE
(Homo
sapiens)		7 / 12ASP A 203
ASP A 327
ASP A 443
MET A 444
ASP A 542
PHE A 575
HIS A 600
GOL  A3001 (-2.6A)
3CU  A1001 (-2.7A)
3CU  A1001 (-2.7A)
3CU  A1001 ( 3.9A)
3CU  A1001 ( 2.5A)
3CU  A1001 (-4.5A)
3CU  A1001 (-3.9A)
0.52A24.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X2I_D_QPSD1050_1
(ALPHA-1,4-GLUCAN
LYASE ISOZYME 1)		3lpp SUCRASE-ISOMALTASE
(Homo
sapiens)		8 / 12ASP A 231
GLN A 232
ASP A 355
ASP A 472
MET A 473
ASP A 571
PHE A 604
HIS A 629
None
None
TRS  A6001 (-2.9A)
TRS  A6001 (-3.2A)
TRS  A6001 ( 3.7A)
TRS  A6001 ( 3.7A)
TRS  A6001 (-4.4A)
TRS  A6001 (-4.2A)
0.69A23.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X2I_D_QPSD1050_1
(ALPHA-1,4-GLUCAN
LYASE ISOZYME 1)		3top MALTASE-GLUCOAMYLASE
, INTESTINAL
(Homo
sapiens)		8 / 12ASP A1157
GLN A1158
ASP A1279
ASP A1420
MET A1421
ASP A1526
PHE A1559
HIS A1584
ACR  A   1 (-2.6A)
ACR  A   1 ( 4.8A)
ACR  A   1 (-3.2A)
ACR  A   1 (-3.6A)
ACR  A   1 (-3.5A)
ACR  A   1 (-2.8A)
ACR  A   1 (-4.3A)
ACR  A   1 (-3.9A)
0.95A24.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X2I_D_QPSD1050_1
(ALPHA-1,4-GLUCAN
LYASE ISOZYME 1)		5dsy POLY [ADP-RIBOSE]
POLYMERASE 2
(Homo
sapiens)		5 / 12GLN A 371
ASN A 544
ASP A 452
MET A 453
PHE A 515
None
1.45A14.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X2I_D_QPSD1050_1
(ALPHA-1,4-GLUCAN
LYASE ISOZYME 1)		5nn8 LYSOSOMAL
ALPHA-GLUCOSIDASE
(Homo
sapiens)		7 / 12ASP A 282
ASP A 404
ASP A 518
MET A 519
ASP A 616
PHE A 649
HIS A 674
ACR  A1015 (-2.6A)
ACR  A1015 (-3.0A)
ACR  A1015 (-3.1A)
ACR  A1015 (-3.3A)
ACR  A1015 (-2.7A)
ACR  A1015 (-4.3A)
ACR  A1015 (-4.0A)
0.57A24.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X2I_D_QPSD1050_2
(ALPHA-1,4-GLUCAN
LYASE ISOZYME 1)		3lpp SUCRASE-ISOMALTASE
(Homo
sapiens)		4 / 5LEU A 233
TRP A 470
ARG A 555
TRP A 568
None
None
TRS  A6001 ( 4.6A)
None
0.80A23.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X2I_D_QPSD1060_1
(ALPHA-1,4-GLUCAN
LYASE ISOZYME 1)		2i6t UBIQUITIN-CONJUGATIN
G ENZYME E2-LIKE
ISOFORM A
(Homo
sapiens)		5 / 10VAL A 248
SER A 400
ASN A 320
VAL A 411
GLY A 316
None
1.39A14.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X2I_D_QPSD1060_1
(ALPHA-1,4-GLUCAN
LYASE ISOZYME 1)		2pg6 CYTOCHROME P450 2A6
(Homo
sapiens)		5 / 10VAL A  92
SER A 433
SER A 369
VAL A 398
GLY A  83
None
HEM  A 500 (-2.6A)
HEM  A 500 ( 3.7A)
None
None
1.37A18.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XFF_A_QPSA600_1
(BETA-AMYLASE)		2ffu POLYPEPTIDE
N-ACETYLGALACTOSAMIN
YLTRANSFERASE 2
(Homo
sapiens)		5 / 12ALA A 148
GLU A 147
PHE A 361
SER A 225
THR A 155
None
None
None
UDP  A 601 (-2.9A)
None
1.28A19.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XFF_A_QPSA600_1
(BETA-AMYLASE)		2vx2 ENOYL-COA HYDRATASE
DOMAIN-CONTAINING
PROTEIN 3
(Homo
sapiens)		5 / 12ALA A  98
SER A 104
GLY A 106
HIS A 107
THR A  69
None
1.43A19.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XFF_A_QPSA600_1
(BETA-AMYLASE)		5ikr PROSTAGLANDIN G/H
SYNTHASE 2
(Homo
sapiens)		5 / 12ALA A 132
ARG A 150
TYR A 460
HIS A 386
THR A 212
None
None
None
COH  A 602 (-3.7A)
COH  A 602 (-2.4A)
1.12A21.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XFF_A_QPSA600_1
(BETA-AMYLASE)		5m32 PROTEASOME SUBUNIT
BETA TYPE-2
(Homo
sapiens)		5 / 12ALA J  22
GLU J   2
GLY J  48
HIS J  99
THR J  53
None
1.42A16.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XFF_A_QPSA600_1
(BETA-AMYLASE)		5ndf POLYPEPTIDE
N-ACETYLGALACTOSAMIN
YLTRANSFERASE 2
(Homo
sapiens)		5 / 12ALA A 148
GLU A 147
PHE A 361
SER A 225
THR A 155
None
None
LU2  A 608 ( 3.4A)
UDP  A 602 (-2.9A)
None
1.28A20.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4BQF_A_QPSA951_1
(ALPHA-GLUCAN
PHOSPHORYLASE 2,
CYTOSOLIC)		1fns VON WILLEBRAND
FACTOR
(Homo
sapiens)		4 / 6MET A 622
GLY A 652
GLU A 666
ARG A 663
None
1.26A12.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4BQF_A_QPSA951_1
(ALPHA-GLUCAN
PHOSPHORYLASE 2,
CYTOSOLIC)		1hyn BAND 3 ANION
TRANSPORT PROTEIN
(Homo
sapiens)		4 / 6GLY P  92
TRP P  94
GLU P  77
ARG P  80
None
1.48A19.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4BQF_A_QPSA951_1
(ALPHA-GLUCAN
PHOSPHORYLASE 2,
CYTOSOLIC)		1w2d INOSITOL-TRISPHOSPHA
TE 3-KINASE A
(Homo
sapiens)		4 / 6GLY A 438
TRP A 435
ARG A 279
ARG A 268
None
0.95A15.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4BQF_A_QPSA951_1
(ALPHA-GLUCAN
PHOSPHORYLASE 2,
CYTOSOLIC)		1ygu LEUKOCYTE COMMON
ANTIGEN
(Homo
sapiens)		4 / 6GLY A 679
ARG A 713
GLU A 670
ARG A 668
None
1.26A20.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4BQF_A_QPSA951_1
(ALPHA-GLUCAN
PHOSPHORYLASE 2,
CYTOSOLIC)		1zs6 NUCLEOSIDE
DIPHOSPHATE KINASE 3
(Homo
sapiens)		4 / 6GLY A 123
ARG A  35
GLU A  40
ARG A  44
None
1.15A11.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4BQF_A_QPSA951_1
(ALPHA-GLUCAN
PHOSPHORYLASE 2,
CYTOSOLIC)		2a98 INOSITOL
1,4,5-TRISPHOSPHATE
3-KINASE C
(Homo
sapiens)		4 / 6GLY A 660
TRP A 657
ARG A 501
ARG A 490
None
1.04A13.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4BQF_A_QPSA951_1
(ALPHA-GLUCAN
PHOSPHORYLASE 2,
CYTOSOLIC)		2o61 TRANSCRIPTION FACTOR
P65/INTERFERON
REGULATORY FACTOR
7/INTERFERON
REGULATORY FACTOR 3
FUSION PROTEIN
(Homo
sapiens)		4 / 6GLY A1020
TRP A1032
ARG A1104
ARG A1037
None
1.11A20.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4BQF_A_QPSA951_1
(ALPHA-GLUCAN
PHOSPHORYLASE 2,
CYTOSOLIC)		3og4 INTERLEUKIN-29
(Homo
sapiens)		4 / 6GLY A  56
TRP A 130
ARG A 160
ARG A 126
None
1.44A12.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4BQF_A_QPSA951_1
(ALPHA-GLUCAN
PHOSPHORYLASE 2,
CYTOSOLIC)		3oq9 PROTEIN FADD
(Homo
sapiens)		4 / 6GLY H 109
TRP H 112
GLU H 130
ARG H 113
None
1.35A7.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4BQF_A_QPSA951_1
(ALPHA-GLUCAN
PHOSPHORYLASE 2,
CYTOSOLIC)		4dqy POLY [ADP-RIBOSE]
POLYMERASE 1
(Homo
sapiens)		4 / 6MET A  38
TRP A  51
GLU A  12
ARG A  34
None
1.42A9.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4BQF_A_QPSA951_1
(ALPHA-GLUCAN
PHOSPHORYLASE 2,
CYTOSOLIC)		4oqa POLY [ADP-RIBOSE]
POLYMERASE 1
(Homo
sapiens)		4 / 6MET A  38
TRP A  51
GLU A  12
ARG A  34
None
1.43A15.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4BQF_A_QPSA951_1
(ALPHA-GLUCAN
PHOSPHORYLASE 2,
CYTOSOLIC)		5m3x ANGIOTENSINOGEN
(Homo
sapiens)		4 / 6GLY A  93
TRP A  92
GLU A 324
ARG A 444
None
1.22A7.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4BQF_B_QPSB951_1
(ALPHA-GLUCAN
PHOSPHORYLASE 2,
CYTOSOLIC)		1w2d INOSITOL-TRISPHOSPHA
TE 3-KINASE A
(Homo
sapiens)		4 / 8ARG A 440
GLU A 394
GLU A 441
ARG A 433
None
1.17A15.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4BQF_B_QPSB951_1
(ALPHA-GLUCAN
PHOSPHORYLASE 2,
CYTOSOLIC)		2cu7 KIAA1915 PROTEIN
(Homo
sapiens)		4 / 8TRP A  12
GLU A  18
GLU A  16
ARG A  41
None
1.25A7.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4BQF_B_QPSB951_1
(ALPHA-GLUCAN
PHOSPHORYLASE 2,
CYTOSOLIC)		2w8q SUCCINATE-SEMIALDEHY
DE DEHYDROGENASE,
MITOCHONDRIAL
(Homo
sapiens)		4 / 8MET A 489
GLU A 515
LYS A 214
ARG A 213
None
None
None
SIN  A3001 (-3.5A)
1.06A21.26
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4BQF_B_QPSB951_1
(ALPHA-GLUCAN
PHOSPHORYLASE 2,
CYTOSOLIC)		3cem GLYCOGEN
PHOSPHORYLASE, LIVER
FORM
(Homo
sapiens)		4 / 8TRP A 361
ARG A 398
GLU A 401
GLU A 405
None
0.35A44.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4BQF_B_QPSB951_1
(ALPHA-GLUCAN
PHOSPHORYLASE 2,
CYTOSOLIC)		3h2x TYROSINE-PROTEIN
PHOSPHATASE
NON-RECEPTOR TYPE 22
(Homo
sapiens)		4 / 8MET A 127
ARG A 172
GLU A 145
GLU A 131
None
None
None
PO4  A 903 ( 3.0A)
1.13A16.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4BQF_B_QPSB951_1
(ALPHA-GLUCAN
PHOSPHORYLASE 2,
CYTOSOLIC)		3odw RHO GUANINE
NUCLEOTIDE EXCHANGE
FACTOR 1
(Homo
sapiens)		4 / 8ARG A 596
GLU A 593
GLU A 589
ARG A 585
None
1.20A19.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4BQF_B_QPSB951_1
(ALPHA-GLUCAN
PHOSPHORYLASE 2,
CYTOSOLIC)		3odx RHO GUANINE
NUCLEOTIDE EXCHANGE
FACTOR 1
(Homo
sapiens)		4 / 8ARG A 596
GLU A 593
GLU A 589
ARG A 585
None
1.18A19.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4BQF_B_QPSB951_1
(ALPHA-GLUCAN
PHOSPHORYLASE 2,
CYTOSOLIC)		3rc0 N-LYSINE
METHYLTRANSFERASE
SETD6
(Homo
sapiens)		4 / 8ARG A 165
TRP A 159
GLU A 163
ARG A 450
None
1.10A18.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4BQF_B_QPSB951_1
(ALPHA-GLUCAN
PHOSPHORYLASE 2,
CYTOSOLIC)		3zzw TYROSINE-PROTEIN
KINASE TRANSMEMBRANE
RECEPTOR ROR2
(Homo
sapiens)		4 / 8ARG A 483
GLU A 520
GLU A 524
ARG A 528
None
1.05A16.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4BQF_B_QPSB951_1
(ALPHA-GLUCAN
PHOSPHORYLASE 2,
CYTOSOLIC)		4dhx 80 KDA
MCM3-ASSOCIATED
PROTEIN
ENHANCER OF YELLOW 2
TRANSCRIPTION FACTOR
HOMOLOG
(Homo
sapiens)		4 / 8ARG B  34
TRP B  42
GLU A1186
LYS B  47
None
1.10A7.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4BQF_B_QPSB951_1
(ALPHA-GLUCAN
PHOSPHORYLASE 2,
CYTOSOLIC)		5ail POLY [ADP-RIBOSE]
POLYMERASE 9
(Homo
sapiens)		4 / 8GLU A 405
GLU A 447
LYS A 450
ARG A 451
EDO  A1458 (-2.5A)
None
None
None
1.18A14.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4BQF_B_QPSB951_1
(ALPHA-GLUCAN
PHOSPHORYLASE 2,
CYTOSOLIC)		5d39 SIGNAL TRANSDUCER
AND ACTIVATOR OF
TRANSCRIPTION 6
(Homo
sapiens)		4 / 8ARG A 260
GLU A 191
GLU A 189
ARG A 140
None
1.12A20.98
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4BQF_B_QPSB951_1
(ALPHA-GLUCAN
PHOSPHORYLASE 2,
CYTOSOLIC)		5ikp GLYCOGEN
PHOSPHORYLASE, BRAIN
FORM
(Homo
sapiens)		4 / 8TRP A 361
ARG A 398
GLU A 401
ARG A 409
None
0.66A45.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4BQF_B_QPSB951_1
(ALPHA-GLUCAN
PHOSPHORYLASE 2,
CYTOSOLIC)		5o32 COMPLEMENT FACTOR
H,COMPLEMENT FACTOR
H
(Homo
sapiens)		4 / 8ARG C1215
GLU C1198
GLU C1195
ARG C1192
None
1.14A17.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4BQF_B_QPSB951_1
(ALPHA-GLUCAN
PHOSPHORYLASE 2,
CYTOSOLIC)		5oho TRANSCRIPTION
ELONGATION FACTOR
SPT5
(Homo
sapiens)		4 / 8ARG A 555
GLU A 556
GLU A 554
ARG A 552
None
1.15A10.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GNF_A_QPSA602_1
(-)		1jd0 CARBONIC ANHYDRASE
XII
(Homo
sapiens)		5 / 12VAL A 143
ARG A 246
GLN A  28
PRO A 205
GLY A 196
AZM  A1400 ( 4.9A)
None
None
None
None
1.44A20.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GNF_A_QPSA602_1
(-)		2p8u HYDROXYMETHYLGLUTARY
L-COA SYNTHASE,
CYTOPLASMIC
(Homo
sapiens)		5 / 12VAL A 337
ASP A  40
PHE A 423
PRO A  27
GLY A 175
None
1.24A23.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GNF_A_QPSA602_1
(-)		3cem GLYCOGEN
PHOSPHORYLASE, LIVER
FORM
(Homo
sapiens)		5 / 12ASP A 339
HIS A 341
ASN A 484
GLU A 672
GLY A 675
None
None
NBG  A   1 (-3.3A)
NBG  A   1 (-3.5A)
PLP  A 832 ( 3.3A)
0.77A22.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GNF_A_QPSA602_1
(-)		3ddu PROLYL ENDOPEPTIDASE
(Homo
sapiens)		5 / 12ASN A 205
ARG A 170
GLN A 193
GLU A 201
GLY A 199
None
1.28A22.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GNF_A_QPSA602_1
(-)		5ikp GLYCOGEN
PHOSPHORYLASE, BRAIN
FORM
(Homo
sapiens)		5 / 12ASP A 339
HIS A 341
ASN A 484
GLU A 672
GLY A 675
None
None
None
None
PLP  A 901 (-3.3A)
0.62A21.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GNF_A_QPSA602_2
(-)		1z8l GLUTAMATE
CARBOXYPEPTIDASE II
(Homo
sapiens)		5 / 9THR A 558
GLY A 384
TYR A 151
HIS A  82
GLU A 145
None
1.23A22.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GNF_A_QPSA602_2
(-)		1z8l GLUTAMATE
CARBOXYPEPTIDASE II
(Homo
sapiens)		5 / 9THR A 558
GLY A 385
GLY A 384
TYR A 151
HIS A  82
None
1.25A22.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GNF_A_QPSA602_2
(-)		3fe1 HEAT SHOCK 70 KDA
PROTEIN 6
(Homo
sapiens)		5 / 9GLY A 205
GLY A 231
TYR A  17
VAL A 348
GLU A 177
None
None
ADP  A 386 (-4.5A)
None
PO4  A 387 (-2.9A)
1.38A24.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GNF_A_QPSA602_2
(-)		5ikp GLYCOGEN
PHOSPHORYLASE, BRAIN
FORM
(Homo
sapiens)		5 / 9GLY A 134
GLY A 135
TYR A 280
HIS A 377
VAL A 455
PLP  A 901 ( 4.1A)
PLP  A 901 ( 3.8A)
None
None
None
0.67A21.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GNF_C_QPSC602_1
(-)		1wao SERINE/THREONINE
PROTEIN PHOSPHATASE
5
(Homo
sapiens)		5 / 10GLY 1 270
LEU 1 300
SER 1 403
VAL 1 239
CYH 1 240
None
1.44A22.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GNF_C_QPSC602_1
(-)		3cxl N-CHIMERIN
(Homo
sapiens)		5 / 10GLY A 296
LEU A 297
TYR A 303
SER A 306
HIS A 407
None
1.23A22.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GNF_C_QPSC602_1
(-)		4ci8 ECHINODERM
MICROTUBULE-ASSOCIAT
ED PROTEIN-LIKE 1
(Homo
sapiens)		5 / 10THR A 788
GLY A 548
LEU A 549
SER A 784
TRP A 812
None
1.44A22.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GNF_C_QPSC602_1
(-)		5h1u TRANSCRIPTION
INTERMEDIARY FACTOR
1-ALPHA
(Homo
sapiens)		5 / 10THR B 947
LEU B 945
SER B 957
VAL B 831
CYH B 852
None
None
None
None
ZN  B1103 (-2.3A)
1.45A16.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GNF_C_QPSC602_1
(-)		5ikp GLYCOGEN
PHOSPHORYLASE, BRAIN
FORM
(Homo
sapiens)		5 / 10GLY A 135
LEU A 136
TYR A 280
HIS A 377
VAL A 455
PLP  A 901 ( 3.8A)
None
None
None
None
0.68A21.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GNF_C_QPSC602_2
(-)		1jd0 CARBONIC ANHYDRASE
XII
(Homo
sapiens)		5 / 12VAL A 143
ARG A 246
GLN A  28
PRO A 205
GLY A 196
AZM  A1400 ( 4.9A)
None
None
None
None
1.46A20.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GNF_C_QPSC602_2
(-)		3cem GLYCOGEN
PHOSPHORYLASE, LIVER
FORM
(Homo
sapiens)		5 / 12ASP A 339
HIS A 341
ASN A 484
GLU A 672
GLY A 675
None
None
NBG  A   1 (-3.3A)
NBG  A   1 (-3.5A)
PLP  A 832 ( 3.3A)
0.76A22.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GNF_C_QPSC602_2
(-)		3ddu PROLYL ENDOPEPTIDASE
(Homo
sapiens)		5 / 12ASN A 205
ARG A 170
GLN A 193
GLU A 201
GLY A 199
None
1.26A22.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GNF_C_QPSC602_2
(-)		5hmp UNCONVENTIONAL
MYOSIN-VC
(Homo
sapiens)		5 / 12VAL A 293
ASP A 213
ARG A 246
GLU A 243
GLY A 289
None
1.18A22.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GNF_C_QPSC602_2
(-)		5ikp GLYCOGEN
PHOSPHORYLASE, BRAIN
FORM
(Homo
sapiens)		5 / 12ASP A 339
HIS A 341
ASN A 484
GLU A 672
GLY A 675
None
None
None
None
PLP  A 901 (-3.3A)
0.63A21.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GNF_C_QPSC602_2
(-)		5kkp PSEUDOURIDYLATE
SYNTHASE 7
(Homo
sapiens)		5 / 12ASN A 471
GLU A 445
GLN A 447
PRO A 468
GLY A 465
None
1.35A21.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GNG_A_QPSA601_1
(-)		1nd7 WW DOMAIN-CONTAINING
PROTEIN 1
(Homo
sapiens)		5 / 12GLY A 860
LEU A 858
THR A 851
GLY A 852
GLN A 805
None
0.98A20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GNG_A_QPSA601_1
(-)		2avd CATECHOL-O-METHYLTRA
NSFERASE
(Homo
sapiens)		5 / 12LEU A  77
THR A 111
GLY A 110
ASP A 185
ASP A  83
None
None
SAM  A 501 (-3.4A)
SAM  A 501 (-3.4A)
None
1.03A16.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GNG_A_QPSA601_1
(-)		2o96 26S PROTEASOME
NON-ATPASE
REGULATORY SUBUNIT 7
(Homo
sapiens)		5 / 12GLY A  27
THR A  97
GLY A  98
ASP A 125
GLN A  32
None
1.16A15.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GNG_A_QPSA601_1
(-)		2qk4 TRIFUNCTIONAL PURINE
BIOSYNTHETIC PROTEIN
ADENOSINE-3
(Homo
sapiens)		5 / 12GLY A  73
THR A  39
GLY A  38
ASN A 290
GLN A 299
None
0.99A24.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GNG_A_QPSA601_1
(-)		3cem GLYCOGEN
PHOSPHORYLASE, LIVER
FORM
(Homo
sapiens)		5 / 12GLY A 134
LEU A 136
ASP A 339
HIS A 341
ASN A 484
PLP  A 832 (-3.6A)
NBG  A   1 (-4.1A)
None
None
NBG  A   1 (-3.3A)
0.89A22.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GNG_A_QPSA601_1
(-)		4igm 2-AMINO-3-CARBOXYMUC
ONATE-6-SEMIALDEHYDE
DECARBOXYLASE
(Homo
sapiens)		5 / 12THR A 116
GLY A 115
LEU A 100
THR A  89
ASN A  98
None
1.15A20.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GNG_A_QPSA601_1
(-)		4zht BIFUNCTIONAL
UDP-N-ACETYLGLUCOSAM
INE
2-EPIMERASE/N-ACETYL
MANNOSAMINE KINASE
(Homo
sapiens)		5 / 12GLY A 299
LEU A 218
VAL A 216
GLY A 140
ASP A 143
None
UDP  A 501 (-4.3A)
None
None
None
1.12A21.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GNG_A_QPSA601_1
(-)		5ikp GLYCOGEN
PHOSPHORYLASE, BRAIN
FORM
(Homo
sapiens)		5 / 12GLY A 134
LEU A 136
ASP A 339
HIS A 341
ASN A 484
PLP  A 901 ( 4.1A)
None
None
None
None
0.73A21.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GNG_A_QPSA601_1
(-)		5vfr 26S PROTEASOME
NON-ATPASE
REGULATORY SUBUNIT
11
26S PROTEASOME
REGULATORY SUBUNIT
6B
(Homo
sapiens)		5 / 12GLY X 273
LEU X 275
GLY D 169
ASP D 171
ASP X 240
None
0.98Aundetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GNG_A_QPSA601_2
(-)		1e33 ARYLSULFATASE A
(Homo
sapiens)		5 / 12GLY P  98
TYR P 149
PRO P 192
GLU P 481
GLY P 480
None
1.35A22.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GNG_A_QPSA601_2
(-)		2xmr PROTEIN NDRG2
(Homo
sapiens)		5 / 12GLU A 291
GLY A 287
TYR A 295
PRO A 242
PRO A 281
None
1.38A17.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GNG_A_QPSA601_2
(-)		3cem GLYCOGEN
PHOSPHORYLASE, LIVER
FORM
(Homo
sapiens)		6 / 12GLU A  88
GLY A 135
HIS A 377
VAL A 455
GLU A 672
GLY A 675
None
PLP  A 832 (-3.9A)
NBG  A   1 (-3.8A)
NBG  A   1 ( 4.5A)
NBG  A   1 (-3.5A)
PLP  A 832 ( 3.3A)
0.64A22.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GNG_A_QPSA601_2
(-)		5ikp GLYCOGEN
PHOSPHORYLASE, BRAIN
FORM
(Homo
sapiens)		7 / 12GLU A  88
GLY A 135
TYR A 280
HIS A 377
VAL A 455
GLU A 672
GLY A 675
None
PLP  A 901 ( 3.8A)
None
None
None
None
PLP  A 901 (-3.3A)
0.78A21.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GNG_B_QPSB601_1
(-)		1n76 LACTOFERRIN
(Homo
sapiens)		5 / 12THR A 131
VAL A 250
TRP A 125
PRO A 144
GLY A 323
None
1.44A20.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GNG_B_QPSB601_1
(-)		4acq ALPHA-2-MACROGLOBULI
N
(Homo
sapiens)		5 / 12THR A1268
VAL A1292
TYR A1264
VAL A1278
GLY A1318
None
1.43A18.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GNG_B_QPSB601_1
(-)		4dlo BRAIN-SPECIFIC
ANGIOGENESIS
INHIBITOR 3
(Homo
sapiens)		5 / 12THR A 627
THR A 599
HIS A 683
VAL A 761
GLY A 688
None
1.31A19.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GNG_B_QPSB601_1
(-)		4krf PROTEIN ARGONAUTE-1
(Homo
sapiens)		5 / 12VAL A 279
THR A 173
VAL A 228
GLU A 266
CYH A 342
None
1.32A20.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GNG_B_QPSB601_1
(-)		4um8 INTEGRIN ALPHA-V
INTEGRIN BETA-6
(Homo
sapiens)		5 / 12VAL B 165
TYR A 221
THR A 249
PRO A 298
GLY B 192
None
1.49A21.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GNG_B_QPSB601_1
(-)		4um8 INTEGRIN ALPHA-V
INTEGRIN BETA-6
(Homo
sapiens)		5 / 12VAL B 169
TYR A 221
THR A 249
PRO A 298
GLY B 192
None
1.45A21.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GNG_B_QPSB601_1
(-)		5ikp GLYCOGEN
PHOSPHORYLASE, BRAIN
FORM
(Homo
sapiens)		5 / 12TYR A 280
HIS A 377
VAL A 455
GLU A 672
GLY A 675
None
None
None
None
PLP  A 901 (-3.3A)
0.76A21.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GNG_B_QPSB601_2
(-)		2p8u HYDROXYMETHYLGLUTARY
L-COA SYNTHASE,
CYTOPLASMIC
(Homo
sapiens)		5 / 12GLY A 173
GLY A 172
GLY A  93
HIS A 264
PRO A 214
None
None
None
SCY  A 129 ( 3.7A)
None
1.06A22.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GNG_B_QPSB601_2
(-)		2wya HYDROXYMETHYLGLUTARY
L-COA SYNTHASE,
MITOCHONDRIAL
(Homo
sapiens)		5 / 12GLY A 210
GLY A 209
GLY A 130
HIS A 301
PRO A 251
None
None
None
HMG  A1509 (-4.1A)
None
1.11A21.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GNG_B_QPSB601_2
(-)		3cem GLYCOGEN
PHOSPHORYLASE, LIVER
FORM
(Homo
sapiens)		6 / 12GLU A  88
GLY A 134
GLY A 135
LEU A 136
HIS A 341
ARG A 569
None
PLP  A 832 (-3.6A)
PLP  A 832 (-3.9A)
NBG  A   1 (-4.1A)
None
None
1.47A22.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GNG_B_QPSB601_2
(-)		3cem GLYCOGEN
PHOSPHORYLASE, LIVER
FORM
(Homo
sapiens)		6 / 12GLU A  88
GLY A 134
GLY A 135
LEU A 136
HIS A 341
ASN A 284
None
PLP  A 832 (-3.6A)
PLP  A 832 (-3.9A)
NBG  A   1 (-4.1A)
None
NBG  A   1 (-3.5A)
1.30A22.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GNG_B_QPSB601_2
(-)		3ox5 CALCIUM-BINDING
PROTEIN 1
(Homo
sapiens)		5 / 12GLY A  76
GLY A  75
LEU A  74
GLY A  48
GLN A  68
None
1.01A13.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GNG_B_QPSB601_2
(-)		4wk4 INTEGRIN ALPHA-5
(Homo
sapiens)		5 / 12GLY A 393
LEU A 394
GLY A 238
ASN A 367
GLU A 246
None
0.93A22.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GNG_B_QPSB601_2
(-)		5epg ALDEHYDE OXIDASE
(Homo
sapiens)		5 / 12GLY A 342
LEU A 341
GLY A 465
HIS A 358
ARG A 429
None
None
None
FAD  A3004 (-4.0A)
FAD  A3004 (-4.1A)
1.06A17.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GNG_B_QPSB601_2
(-)		5ikp GLYCOGEN
PHOSPHORYLASE, BRAIN
FORM
(Homo
sapiens)		5 / 12GLU A  88
GLY A 134
GLY A 135
LEU A 136
HIS A 341
None
PLP  A 901 ( 4.1A)
PLP  A 901 ( 3.8A)
None
None
0.59A21.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GNG_B_QPSB601_3
(-)		2hi4 CYTOCHROME P450 1A2
(Homo
sapiens)		3 / 3ASP A 103
ASP A 128
ASN A 309
None
0.65A21.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GNG_B_QPSB601_3
(-)		2lav VACCINIA-RELATED
KINASE 1
(Homo
sapiens)		3 / 3ASP A 222
ASP A 197
ASN A 346
None
0.74A20.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GNG_B_QPSB601_3
(-)		2p1f URIDINE
5'-MONOPHOSPHATE
SYNTHASE
(Homo
sapiens)		3 / 3ASP A 100
ASP A  96
ASN A 152
None
0.85A20.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GNG_B_QPSB601_3
(-)		2qcm URIDINE
5'-MONOPHOSPHATE
SYNTHASE (UMP
SYNTHASE)
(Homo
sapiens)		3 / 3ASP A 289
ASP A 285
ASN A 341
None
None
JW5  A 482 (-4.3A)
0.83A19.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GNG_B_QPSB601_3
(-)		2vpj KELCH-LIKE PROTEIN
12
(Homo
sapiens)		3 / 3ASP A 350
ASP A 404
ASN A 366
None
0.85A17.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GNG_B_QPSB601_3
(-)		3ibj CGMP-DEPENDENT
3',5'-CYCLIC
PHOSPHODIESTERASE
(Homo
sapiens)		3 / 3ASP A 683
ASP A 625
ASN A 599
None
0.86A21.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GNG_B_QPSB601_3
(-)		4fdd RNA-BINDING PROTEIN
FUS
TRANSPORTIN-1
(Homo
sapiens)		3 / 3ASP B 520
ASP B 512
ASN A 770
None
0.86A4.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GNG_B_QPSB601_3
(-)		4i8v CYTOCHROME P450 1A1
(Homo
sapiens)		3 / 3ASP A 101
ASP A 126
ASN A 309
None
0.60A23.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GNG_B_QPSB601_3
(-)		5d1z IRON-REGULATED
SURFACE DETERMINANT
PROTEIN B
Y10 HEAVY CHAIN
(Homo
sapiens;
Staphylococcus
aureus)		3 / 3ASP B  63
ASP B  51
ASN I 135
None
0.79A19.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GNG_B_QPSB601_3
(-)		5fws KREMEN PROTEIN 1
(Homo
sapiens)		3 / 3ASP A 306
ASP A 260
ASN A  36
 CA  A1327 (-2.8A)
None
None
0.55A21.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GNG_B_QPSB601_3
(-)		5fww KREMEN PROTEIN 1
(Homo
sapiens)		3 / 3ASP B 306
ASP B 260
ASN B  36
 CA  B1323 (-3.5A)
None
None
0.75A17.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GNG_B_QPSB601_3
(-)		5hp5 PROTEIN-ARGININE
DEIMINASE TYPE-1
(Homo
sapiens)		3 / 3ASP A 352
ASP A 585
ASN A 540
None
0.78A23.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GNG_B_QPSB601_3
(-)		5m8t 5,6-DIHYDROXYINDOLE-
2-CARBOXYLIC ACID
OXIDASE
(Homo
sapiens)		3 / 3ASP A 297
ASP A 212
ASN A 449
None
0.86A20.13