POTENTIAL TARGETS FROM HUMAN (RESULTS FROM SUB-STRUCTURAL SIMILARITY SEARCHES)
1) User may click on the DrReposER ID (the second column) to get information on the binding sites and drug molecule.
2) Click View (the second last column) to view matched residues and superposition in the NGL viewer (upper right part).
3) User may also click on the Dock (the last column) to get script for molecular docking in UCSF Chimera through AutoDock Vina.

DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GTB_A_PZQA901_0
(GLUTATHIONE
S-TRANSFERASE)		1om9 ADP-RIBOSYLATION
FACTOR BINDING
PROTEIN GGA1
(Homo
sapiens)		3 / 3GLN A 520
TYR A 610
ARG A 609
None
0.79A22.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GTB_A_PZQA901_0
(GLUTATHIONE
S-TRANSFERASE)		1s9c PEROXISOMAL
MULTIFUNCTIONAL
ENZYME TYPE 2
(Homo
sapiens)		3 / 3GLN A  92
TYR A 188
ARG A 189
None
0.95A22.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GTB_A_PZQA901_0
(GLUTATHIONE
S-TRANSFERASE)		2e0t DUAL SPECIFICITY
PHOSPHATASE 26
(Homo
sapiens)		3 / 3GLN A  74
TYR A 106
ARG A 112
None
0.93A22.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GTB_A_PZQA901_0
(GLUTATHIONE
S-TRANSFERASE)		2jnu REGULATOR OF
G-PROTEIN SIGNALING
14
(Homo
sapiens)		3 / 3GLN A   6
TYR A 127
ARG A 128
None
0.84A20.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GTB_A_PZQA901_0
(GLUTATHIONE
S-TRANSFERASE)		2xa7 ADAPTOR-RELATED
PROTEIN COMPLEX 2,
ALPHA 2 SUBUNIT
AP-2 COMPLEX SUBUNIT
BETA
(Rattus
norvegicus;
Homo
sapiens)		3 / 3GLN B 481
TYR A 463
ARG A 464
None
0.62A16.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GTB_A_PZQA901_0
(GLUTATHIONE
S-TRANSFERASE)		2xyd ANGIOTENSIN-CONVERTI
NG ENZYME
(Homo
sapiens)		3 / 3GLN A   9
TYR A  76
ARG A  96
None
None
PEG  A1624 (-4.1A)
0.87A17.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GTB_A_PZQA901_0
(GLUTATHIONE
S-TRANSFERASE)		2yd0 ENDOPLASMIC
RETICULUM
AMINOPEPTIDASE 1
(Homo
sapiens)		3 / 3GLN A 358
TYR A 327
ARG A 328
None
0.90A13.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GTB_A_PZQA901_0
(GLUTATHIONE
S-TRANSFERASE)		3l5h INTERLEUKIN-6
RECEPTOR SUBUNIT
BETA
(Homo
sapiens)		3 / 3GLN A 356
TYR A 374
ARG A 373
None
None
SO4  A 592 (-3.0A)
0.89A16.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GTB_A_PZQA901_0
(GLUTATHIONE
S-TRANSFERASE)		4byf UNCONVENTIONAL
MYOSIN-IC
(Homo
sapiens)		3 / 3GLN A 610
TYR A  55
ARG A  56
None
AOV  A1001 ( 4.5A)
None
0.76A14.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GTB_A_PZQA901_0
(GLUTATHIONE
S-TRANSFERASE)		4fm9 DNA TOPOISOMERASE
2-ALPHA
(Homo
sapiens)		3 / 3GLN A 933
TYR A 957
ARG A 958
None
0.88A15.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GTB_A_PZQA901_0
(GLUTATHIONE
S-TRANSFERASE)		4fys AMINOPEPTIDASE N
(Homo
sapiens)		3 / 3GLN A 393
TYR A 362
ARG A 363
None
0.81A13.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GTB_A_PZQA901_0
(GLUTATHIONE
S-TRANSFERASE)		4jkg PRE-MRNA-PROCESSING-
SPLICING FACTOR 8
(Homo
sapiens)		3 / 3GLN B1835
TYR B1786
ARG B1787
None
0.82A22.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GTB_A_PZQA901_0
(GLUTATHIONE
S-TRANSFERASE)		4kxb GLUTAMYL
AMINOPEPTIDASE
(Homo
sapiens)		3 / 3GLN A 398
TYR A 367
ARG A 368
None
0.89A14.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GTB_A_PZQA901_0
(GLUTATHIONE
S-TRANSFERASE)		4n9f CORE-BINDING FACTOR
SUBUNIT BETA
VIRION INFECTIVITY
FACTOR
(Homo
sapiens;
Human
immunodeficiency
virus
1)		3 / 3GLN a   8
TYR b  94
ARG b  93
None
0.93A22.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GTB_A_PZQA901_0
(GLUTATHIONE
S-TRANSFERASE)		4wk7 A DISINTEGRIN AND
METALLOPROTEINASE
WITH THROMBOSPONDIN
MOTIFS 4
(Homo
sapiens)		3 / 3GLN A 354
TYR A 241
ARG A 240
None
0.81A19.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GTB_A_PZQA901_0
(GLUTATHIONE
S-TRANSFERASE)		4zel DOPAMINE
BETA-HYDROXYLASE
(Homo
sapiens)		3 / 3GLN A 410
TYR A 249
ARG A 350
None
0.87A16.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GTB_A_PZQA901_0
(GLUTATHIONE
S-TRANSFERASE)		5bqc NORRIN
FRIZZLED-4
(Homo
sapiens;
Homo
sapiens)		3 / 3GLN B  93
TYR A 122
ARG A 121
None
0.94A18.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GTB_A_PZQA901_0
(GLUTATHIONE
S-TRANSFERASE)		5ikp GLYCOGEN
PHOSPHORYLASE, BRAIN
FORM
(Homo
sapiens)		3 / 3GLN A 539
TYR A 791
ARG A 792
None
0.91A14.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GTB_A_PZQA901_0
(GLUTATHIONE
S-TRANSFERASE)		5j6s ENDOPLASMIC
RETICULUM
AMINOPEPTIDASE 2
(Homo
sapiens)		3 / 3GLN A 375
TYR A 344
ARG A 345
None
0.81A12.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GTB_A_PZQA901_0
(GLUTATHIONE
S-TRANSFERASE)		5v4n ALPHA3(135-145)-HLA-
DRB1*01:01
(Homo
sapiens)		3 / 3GLN C 319
TYR C 296
ARG C 288
None
0.95A19.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GTB_A_PZQA901_0
(GLUTATHIONE
S-TRANSFERASE)		5w7c ACYLOXYACYL
HYDROLASE
(Homo
sapiens)		3 / 3GLN C 572
TYR C 320
ARG C 322
None
0.93Aundetectable