POTENTIAL TARGETS FROM HUMAN (RESULTS FROM SUB-STRUCTURAL SIMILARITY SEARCHES)
1) User may click on the DrReposER ID (the second column) to get information on the binding sites and drug molecule.
2) Click View (the second last column) to view matched residues and superposition in the NGL viewer (upper right part).
3) User may also click on the Dock (the last column) to get script for molecular docking in UCSF Chimera through AutoDock Vina.

DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LSF_B_PZIB800_0
(GLUTAMATE RECEPTOR 2)		4xsv ETHANOLAMINE-PHOSPHA
TE
CYTIDYLYLTRANSFERASE
(Homo
sapiens)		5 / 10PRO A 264
MET A 266
ASP A 148
SER A 191
GLY A 189
None
1.14A20.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LSF_B_PZIB802_0
(GLUTAMATE RECEPTOR 2)		1e33 ARYLSULFATASE A
(Homo
sapiens)		3 / 3SER P 150
ASP P  29
ASN P 282
DDZ  P  69 ( 4.9A)
MG  P 603 (-3.1A)
MG  P 603 (-2.9A)
0.97A18.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LSF_B_PZIB802_0
(GLUTAMATE RECEPTOR 2)		1lpb LIPASE
(Homo
sapiens)		3 / 3SER B 333
ASP B 272
ASN B  92
BOG  B 452 (-3.5A)
None
None
0.99A18.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LSF_B_PZIB802_0
(GLUTAMATE RECEPTOR 2)		2c4k PHOSPHORIBOSYL
PYROPHOSPHATE
SYNTHETASE-ASSOCIATE
D PROTEIN 1
(Homo
sapiens)		3 / 3SER A 154
ASP A 134
ASN A 150
None
0.91A21.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LSF_B_PZIB802_0
(GLUTAMATE RECEPTOR 2)		2gsb RAS
GTPASE-ACTIVATING
PROTEIN 1
(Homo
sapiens)		3 / 3SER A  24
ASP A  47
ASN A  48
None
0.98A18.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LSF_B_PZIB802_0
(GLUTAMATE RECEPTOR 2)		3i3t UBIQUITIN
CARBOXYL-TERMINAL
HYDROLASE 21
(Homo
sapiens)		3 / 3SER A 494
ASP A 352
ASN A 356
None
0.77A21.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LSF_B_PZIB802_0
(GLUTAMATE RECEPTOR 2)		3jwo HIV-1 GP120 ENVELOPE
GLYCOPROTEIN
(Homo
sapiens)		3 / 3SER A 365
ASP A 457
ASN A 462
None
0.89A20.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LSF_B_PZIB802_0
(GLUTAMATE RECEPTOR 2)		3o4r DEHYDROGENASE/REDUCT
ASE SDR FAMILY
MEMBER 4
(Homo
sapiens)		3 / 3SER A 218
ASP A  42
ASN A  68
NAP  A 601 ( 4.4A)
NAP  A 601 (-3.9A)
NAP  A 601 (-3.8A)
1.02A22.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LSF_B_PZIB802_0
(GLUTAMATE RECEPTOR 2)		3ojy COMPLEMENT COMPONENT
C8 BETA CHAIN
(Homo
sapiens)		3 / 3SER B 232
ASP B 491
ASN B 515
None
0.87A19.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LSF_B_PZIB802_0
(GLUTAMATE RECEPTOR 2)		3thw DNA MISMATCH REPAIR
PROTEIN MSH3
(Homo
sapiens)		3 / 3SER B 403
ASP B 398
ASN B 376
None
1.01A14.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LSF_B_PZIB802_0
(GLUTAMATE RECEPTOR 2)		4bb9 GLUCOKINASE
REGULATORY PROTEIN
(Homo
sapiens)		3 / 3SER A 224
ASP A 192
ASN A 196
None
0.85A17.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LSF_B_PZIB802_0
(GLUTAMATE RECEPTOR 2)		4fdd TRANSPORTIN-1
(Homo
sapiens)		3 / 3SER A 841
ASP A 806
ASN A 807
None
0.81A14.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LSF_B_PZIB802_0
(GLUTAMATE RECEPTOR 2)		4pj3 INTRON-BINDING
PROTEIN AQUARIUS
(Homo
sapiens)		3 / 3SER A1142
ASP A1176
ASN A1170
None
0.95A10.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LSF_B_PZIB802_0
(GLUTAMATE RECEPTOR 2)		4ylr TUBULIN
POLYGLUTAMYLASE
TTLL7
(Homo
sapiens)		3 / 3SER A 273
ASP A 223
ASN A 453
None
0.96A20.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LSF_B_PZIB802_0
(GLUTAMATE RECEPTOR 2)		5j39 TUDOR AND KH
DOMAIN-CONTAINING
PROTEIN
(Homo
sapiens)		3 / 3SER A 313
ASP A 393
ASN A 394
None
CAC  A 501 (-3.6A)
None
0.97A23.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LSF_B_PZIB802_0
(GLUTAMATE RECEPTOR 2)		5lkn NEURAL CELL ADHESION
MOLECULE 1
(Homo
sapiens)		3 / 3SER A 643
ASP A 664
ASN A 666
None
0.97A15.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LSF_B_PZIB802_0
(GLUTAMATE RECEPTOR 2)		5u1d ANTIGEN PEPTIDE
TRANSPORTER 1
ANTIGEN PEPTIDE
TRANSPORTER 2
TAP TRANSPORTER
INHIBITOR ICP47
(Homo
sapiens;
Homo
sapiens;
Human
alphaherpesvirus
1)		3 / 3SER A 412
ASP X   9
ASN B 269
None
0.92A16.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LSF_E_PZIE800_0
(GLUTAMATE RECEPTOR 2)		1a4i METHYLENETETRAHYDROF
OLATE DEHYDROGENASE
/
METHENYLTETRAHYDROFO
LATE CYCLOHYDROLASE
(Homo
sapiens)		5 / 10PRO A 180
SER A 174
GLY A 178
PRO A 149
ASP A 235
None
NDP  A 302 (-2.6A)
None
None
None
1.23A22.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LSF_E_PZIE802_0
(GLUTAMATE RECEPTOR 2)		1lpb LIPASE
(Homo
sapiens)		3 / 3ASP B 272
ASN B  92
SER B 333
None
None
BOG  B 452 (-3.5A)
0.99A18.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LSF_E_PZIE802_0
(GLUTAMATE RECEPTOR 2)		2c4k PHOSPHORIBOSYL
PYROPHOSPHATE
SYNTHETASE-ASSOCIATE
D PROTEIN 1
(Homo
sapiens)		3 / 3ASP A 134
ASN A 150
SER A 154
None
0.96A21.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LSF_E_PZIE802_0
(GLUTAMATE RECEPTOR 2)		2gsb RAS
GTPASE-ACTIVATING
PROTEIN 1
(Homo
sapiens)		3 / 3ASP A  47
ASN A  48
SER A  24
None
0.95A18.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LSF_E_PZIE802_0
(GLUTAMATE RECEPTOR 2)		3i3t UBIQUITIN
CARBOXYL-TERMINAL
HYDROLASE 21
(Homo
sapiens)		3 / 3ASP A 352
ASN A 356
SER A 494
None
0.81A21.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LSF_E_PZIE802_0
(GLUTAMATE RECEPTOR 2)		3jwo HIV-1 GP120 ENVELOPE
GLYCOPROTEIN
(Homo
sapiens)		3 / 3ASP A 457
ASN A 462
SER A 365
None
0.85A20.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LSF_E_PZIE802_0
(GLUTAMATE RECEPTOR 2)		3ojy COMPLEMENT COMPONENT
C8 BETA CHAIN
(Homo
sapiens)		3 / 3ASP B 491
ASN B 515
SER B 232
None
0.82A19.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LSF_E_PZIE802_0
(GLUTAMATE RECEPTOR 2)		3thw DNA MISMATCH REPAIR
PROTEIN MSH3
(Homo
sapiens)		3 / 3ASP B 398
ASN B 376
SER B 403
None
1.02A14.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LSF_E_PZIE802_0
(GLUTAMATE RECEPTOR 2)		4bb9 GLUCOKINASE
REGULATORY PROTEIN
(Homo
sapiens)		3 / 3ASP A 192
ASN A 196
SER A 224
None
0.81A17.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LSF_E_PZIE802_0
(GLUTAMATE RECEPTOR 2)		4fdd TRANSPORTIN-1
(Homo
sapiens)		3 / 3ASP A 806
ASN A 807
SER A 841
None
0.88A14.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LSF_E_PZIE802_0
(GLUTAMATE RECEPTOR 2)		4pj3 INTRON-BINDING
PROTEIN AQUARIUS
(Homo
sapiens)		3 / 3ASP A1176
ASN A1170
SER A1142
None
0.89A10.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LSF_E_PZIE802_0
(GLUTAMATE RECEPTOR 2)		4ylr TUBULIN
POLYGLUTAMYLASE
TTLL7
(Homo
sapiens)		3 / 3ASP A 223
ASN A 453
SER A 273
None
0.91A20.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LSF_E_PZIE802_0
(GLUTAMATE RECEPTOR 2)		5lkn NEURAL CELL ADHESION
MOLECULE 1
(Homo
sapiens)		3 / 3ASP A 664
ASN A 666
SER A 643
None
0.89A15.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LSF_E_PZIE802_0
(GLUTAMATE RECEPTOR 2)		5u1d ANTIGEN PEPTIDE
TRANSPORTER 1
ANTIGEN PEPTIDE
TRANSPORTER 2
TAP TRANSPORTER
INHIBITOR ICP47
(Homo
sapiens;
Homo
sapiens;
Human
alphaherpesvirus
1)		3 / 3ASP X   9
ASN B 269
SER A 412
None
0.95A18.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LSF_E_PZIE802_0
(GLUTAMATE RECEPTOR 2)		6cbp DH270.6 SINGLE CHAIN
VARIABLE FRAGMENT
MAN9-V3 GLYCOPEPTIDE
(Homo
sapiens;
Human
immunodeficiency
virus
1)		3 / 3ASP A 107
ASN P 300
SER A 109
None
1.01Aundetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LSF_E_PZIE802_0
(GLUTAMATE RECEPTOR 2)		6es1 SYNAPTIC VESICLE
GLYCOPROTEIN 2C
(Homo
sapiens)		3 / 3ASP B 546
ASN B 565
SER B 527
None
0.93Aundetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LSF_H_PZIH800_0
(GLUTAMATE RECEPTOR 2)		1ypo OXIDISED LOW DENSITY
LIPOPROTEIN
(LECTIN-LIKE)
RECEPTOR 1
(Homo
sapiens)		4 / 8PRO A 214
SER A 207
LEU A 206
LYS A 181
None
1.10A16.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LSF_H_PZIH800_0
(GLUTAMATE RECEPTOR 2)		2cw9 TRANSLOCASE OF INNER
MITOCHONDRIAL
MEMBRANE
(Homo
sapiens)		4 / 8TYR A 348
LEU A 336
ASP A 337
LYS A 340
None
0.86A22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LSF_H_PZIH800_0
(GLUTAMATE RECEPTOR 2)		2d7m FILAMIN-C
(Homo
sapiens)		4 / 8TYR A  82
PRO A 104
SER A  29
ASP A  77
None
1.13A18.22
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3LSF_H_PZIH800_0
(GLUTAMATE RECEPTOR 2)		2zns GLUTAMATE RECEPTOR,
IONOTROPIC KAINATE 1
(Homo
sapiens)		5 / 8TYR A 448
PRO A 517
MET A 519
LEU A 776
LYS A 780
None
0.33A51.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LSF_H_PZIH800_0
(GLUTAMATE RECEPTOR 2)		3bfn KINESIN-LIKE PROTEIN
KIF22
(Homo
sapiens)		4 / 8PRO A 214
SER A 175
LEU A 188
ASP A 186
None
0.98A19.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LSF_H_PZIH800_0
(GLUTAMATE RECEPTOR 2)		3ebb PHOSPHOLIPASE
A2-ACTIVATING
PROTEIN
(Homo
sapiens)		4 / 8TYR A 775
SER A 770
SER A 730
LEU A 733
None
1.03A20.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LSF_H_PZIH800_0
(GLUTAMATE RECEPTOR 2)		3pqy ALPHA CHAIN OF THE
6218-TCR
BETA CHAIN OF THE
6218-TCR
(Homo
sapiens;
Mus
musculus;
Homo
sapiens;
Mus
musculus)		4 / 8TYR E  42
SER E 107
SER D 107
LEU D 114
None
0.98A20.35
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3LSF_H_PZIH800_0
(GLUTAMATE RECEPTOR 2)		3qxm GLUTAMATE RECEPTOR
IONOTROPIC, KAINATE
2
(Homo
sapiens)		5 / 8TYR A 431
PRO A 501
MET A 503
LEU A 760
LYS A 764
None
0.36A51.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LSF_H_PZIH800_0
(GLUTAMATE RECEPTOR 2)		4bxo FANCONI ANEMIA GROUP
M PROTEIN
(Homo
sapiens)		4 / 8TYR A1976
MET A2000
SER A2003
SER A1995
None
1.02A22.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LSF_H_PZIH800_0
(GLUTAMATE RECEPTOR 2)		4htp DNA LIGASE 4
(Homo
sapiens)		4 / 8PRO A  66
SER A  63
LEU A 221
ASP A 220
None
1.08A20.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LSF_H_PZIH800_0
(GLUTAMATE RECEPTOR 2)		4m6w FANCONI ANEMIA GROUP
M PROTEIN
(Homo
sapiens)		4 / 8TYR A1976
MET A2000
SER A2003
SER A1995
None
0.98A21.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LSL_A_PZIA800_0
(GLUTAMATE RECEPTOR 2)		1gux RETINOBLASTOMA
PROTEIN
(Homo
sapiens)		4 / 7LEU A 572
ASP A 571
LYS A 574
SER A 567
None
1.37A22.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LSL_A_PZIA800_0
(GLUTAMATE RECEPTOR 2)		1ohe CDC14B2 PHOSPHATASE
(Homo
sapiens)		4 / 7TYR A 248
ASN A 217
LEU A 216
ASP A 215
None
1.41A22.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LSL_A_PZIA800_0
(GLUTAMATE RECEPTOR 2)		2cw9 TRANSLOCASE OF INNER
MITOCHONDRIAL
MEMBRANE
(Homo
sapiens)		4 / 7TYR A 348
LEU A 336
ASP A 337
LYS A 340
None
0.90A21.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LSL_A_PZIA800_0
(GLUTAMATE RECEPTOR 2)		2z7x TOLL-LIKE RECEPTOR
2, VARIABLE
LYMPHOCYTE RECEPTOR
B
(Eptatretus
burgeri;
Homo
sapiens)		4 / 7ASN A 110
LEU A  83
ASP A 106
SER A  85
None
1.39A19.20
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3LSL_A_PZIA800_0
(GLUTAMATE RECEPTOR 2)		2zns GLUTAMATE RECEPTOR,
IONOTROPIC KAINATE 1
(Homo
sapiens)		4 / 7TYR A 448
MET A 519
LEU A 776
LYS A 780
None
0.45A51.92
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3LSL_A_PZIA800_0
(GLUTAMATE RECEPTOR 2)		3qxm GLUTAMATE RECEPTOR
IONOTROPIC, KAINATE
2
(Homo
sapiens)		4 / 7TYR A 431
MET A 503
LEU A 760
LYS A 764
None
0.48A51.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LSL_A_PZIA800_0
(GLUTAMATE RECEPTOR 2)		3w1g DNA LIGASE 4
(Homo
sapiens)		4 / 7TYR A  82
ASN A 149
LEU A 152
ASP A 153
None
1.16A17.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LSL_A_PZIA800_0
(GLUTAMATE RECEPTOR 2)		4erv RYANODINE RECEPTOR 3
(Homo
sapiens)		4 / 7TYR A2743
LEU A2787
ASP A2786
SER A2625
None
1.36A21.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LSL_A_PZIA800_0
(GLUTAMATE RECEPTOR 2)		4htp DNA LIGASE 4
(Homo
sapiens)		4 / 7TYR A  82
ASN A 149
LEU A 152
ASP A 153
None
1.10A20.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LSL_A_PZIA800_0
(GLUTAMATE RECEPTOR 2)		4qgu GAMMA-INTERFERON-IND
UCIBLE PROTEIN 16
(Homo
sapiens)		4 / 7TYR A 218
ASN A 274
LEU A 245
LYS A 226
None
1.22A19.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LSL_A_PZIA800_0
(GLUTAMATE RECEPTOR 2)		4w79 PROTEIN N-TERMINAL
GLUTAMINE
AMIDOHYDROLASE
(Homo
sapiens)		4 / 7ASN A  31
LEU A  98
ASP A  99
SER A  25
None
1.02A20.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LSL_A_PZIA800_0
(GLUTAMATE RECEPTOR 2)		5fww KREMEN PROTEIN 1
DICKKOPF-RELATED
PROTEIN 1
(Homo
sapiens;
Homo
sapiens)		4 / 7TYR B 165
LEU C 190
LYS C 208
SER C 193
None
1.39A22.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LSL_A_PZIA800_0
(GLUTAMATE RECEPTOR 2)		5lt1 KINESIN-LIKE PROTEIN
(Homo
sapiens)		4 / 7TYR A 118
ASN A 216
LEU A 126
ASP A 123
None
1.06A22.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LSL_A_PZIA800_0
(GLUTAMATE RECEPTOR 2)		5m8t 5,6-DIHYDROXYINDOLE-
2-CARBOXYLIC ACID
OXIDASE
(Homo
sapiens)		4 / 7TYR A 185
LEU A 148
ASP A 149
LYS A 152
None
1.27A20.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LSL_A_PZIA800_0
(GLUTAMATE RECEPTOR 2)		6bnl NKT VALPHA14 (MOUSE)
- 2C12 TCR - HYBRID
MOUSE VARIABLE AND
HUMAN CONSTANT
DOMAINS
(Homo
sapiens)		4 / 7TYR C  24
LEU C  66
ASP C  67
LYS C  71
None
1.40Aundetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LSL_A_PZIA800_0
(GLUTAMATE RECEPTOR 2)		6d42 INTERMEDIATE
CONDUCTANCE
CALCIUM-ACTIVATED
POTASSIUM CHANNEL
PROTEIN 4
(Homo
sapiens)		4 / 7ASN A 384
LEU A 381
ASP A 380
LYS A 376
None
1.37Aundetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LSL_A_PZIA801_0
(GLUTAMATE RECEPTOR 2)		1hxm GAMMA-DELTA T-CELL
RECEPTOR
(Homo
sapiens)		4 / 8ILE A 169
PRO A 119
GLY A 173
ASN A 176
None
0.91A21.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LSL_A_PZIA801_0
(GLUTAMATE RECEPTOR 2)		1uap PROCOLLAGEN
C-PROTEINASE
ENHANCER PROTEIN
(Homo
sapiens)		4 / 8PRO A 125
SER A  48
GLY A 114
SER A  24
None
0.97A19.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LSL_A_PZIA801_0
(GLUTAMATE RECEPTOR 2)		1yzg ADP-RIBOSYLATION
FACTOR-LIKE 8
(Homo
sapiens)		4 / 8ILE A  48
SER A  76
GLY A  49
PRO A  46
None
0.94A19.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LSL_A_PZIA801_0
(GLUTAMATE RECEPTOR 2)		2c11 MEMBRANE COPPER
AMINE OXIDASE
(Homo
sapiens)		4 / 8PRO A 215
GLY A 217
PRO A 653
SER A 620
None
0.86A15.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LSL_A_PZIA801_0
(GLUTAMATE RECEPTOR 2)		2il1 RAB12
(Homo
sapiens)		4 / 8ILE A 144
SER A 146
GLY A 145
ASN A 201
None
0.96A22.27
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3LSL_A_PZIA801_0
(GLUTAMATE RECEPTOR 2)		2zns GLUTAMATE RECEPTOR,
IONOTROPIC KAINATE 1
(Homo
sapiens)		4 / 8ILE A 504
PRO A 517
SER A 746
GLY A 748
None
0.25A51.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LSL_A_PZIA801_0
(GLUTAMATE RECEPTOR 2)		3a1f CYTOCHROME B-245
HEAVY CHAIN
(Homo
sapiens)		4 / 8ILE A   1
SER A  11
GLY A   8
SER A  38
 NI  A 193 (-4.0A)
None
None
None
0.83A20.46
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3LSL_A_PZIA801_0
(GLUTAMATE RECEPTOR 2)		3qxm GLUTAMATE RECEPTOR
IONOTROPIC, KAINATE
2
(Homo
sapiens)		4 / 8ILE A 488
PRO A 501
SER A 730
GLY A 732
None
0.26A51.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LSL_A_PZIA801_0
(GLUTAMATE RECEPTOR 2)		4j1y COMPLEMENT C1S
SUBCOMPONENT
(Homo
sapiens)		5 / 8ILE A 361
PRO A 362
GLY A 360
PRO A 373
SER A 380
None
1.26A22.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LSL_A_PZIA801_0
(GLUTAMATE RECEPTOR 2)		4leo RECEPTOR
TYROSINE-PROTEIN
KINASE ERBB-3
(Homo
sapiens)		4 / 8ILE C 374
SER C 403
GLY C 376
SER C 317
None
0.90A17.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LSL_A_PZIA801_0
(GLUTAMATE RECEPTOR 2)		4lr2 BIS(5'-ADENOSYL)-TRI
PHOSPHATASE ENPP4
(Homo
sapiens)		4 / 8ILE A 214
GLY A 215
PRO A  47
ASN A  51
None
0.94A20.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LSL_A_PZIA801_0
(GLUTAMATE RECEPTOR 2)		5epg ALDEHYDE OXIDASE
(Homo
sapiens)		4 / 8GLY A 346
PRO A  70
SER A 124
ASN A  72
None
None
None
FES  A3002 ( 3.8A)
0.78A12.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LSL_A_PZIA802_0
(GLUTAMATE RECEPTOR 2)		1vfd LACTOFERRIN
(Homo
sapiens)		3 / 3ASP A  55
ASN A  52
SER A   5
None
0.90A21.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LSL_A_PZIA802_0
(GLUTAMATE RECEPTOR 2)		2kxn TRANSFORMER-2
PROTEIN HOMOLOG BETA
(Homo
sapiens)		3 / 3ASP B 192
ASN B 180
SER B 194
None
None
G  A   3 ( 2.3A)
0.98A19.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LSL_A_PZIA802_0
(GLUTAMATE RECEPTOR 2)		2wnp FICOLIN-1
(Homo
sapiens)		3 / 3ASP F 235
ASN F 225
SER F 239
 CA  F1298 (-2.6A)
None
None
0.83A21.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LSL_A_PZIA802_0
(GLUTAMATE RECEPTOR 2)		3cuq VACUOLAR
PROTEIN-SORTING-ASSO
CIATED PROTEIN 36
VACUOLAR
PROTEIN-SORTING-ASSO
CIATED PROTEIN 25
(Homo
sapiens;
Homo
sapiens)		3 / 3ASP C  24
ASN C  22
SER B 339
None
0.89A20.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LSL_A_PZIA802_0
(GLUTAMATE RECEPTOR 2)		3jwo HIV-1 GP120 ENVELOPE
GLYCOPROTEIN
(Homo
sapiens)		3 / 3ASP A 457
ASN A 462
SER A 365
None
0.73A20.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LSL_A_PZIA802_0
(GLUTAMATE RECEPTOR 2)		3ojy COMPLEMENT COMPONENT
C8 BETA CHAIN
(Homo
sapiens)		3 / 3ASP B 491
ASN B 515
SER B 232
None
0.89A19.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LSL_A_PZIA802_0
(GLUTAMATE RECEPTOR 2)		4k8y KALLIKREIN-4
(Homo
sapiens)		3 / 3ASP A 102
ASN A  95
SER A 195
None
0.94A22.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LSL_A_PZIA802_0
(GLUTAMATE RECEPTOR 2)		4lnz UNCONVENTIONAL
MYOSIN-VB
(Homo
sapiens)		3 / 3ASP A1513
ASN A1516
SER A1564
None
0.84A20.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LSL_A_PZIA802_0
(GLUTAMATE RECEPTOR 2)		4mqt MUSCARINIC
ACETYLCHOLINE
RECEPTOR M2
NANOBODY 9-8
(Homo
sapiens;
Lama
glama)		3 / 3ASP B  33
ASN B  77
SER A 380
None
0.81A18.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LSL_A_PZIA802_0
(GLUTAMATE RECEPTOR 2)		4zdl O-PHOSPHOSERYL-TRNA(
SEC) SELENIUM
TRANSFERASE
(Homo
sapiens)		3 / 3ASP A  62
ASN A  64
SER A 112
None
0.85A20.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LSL_A_PZIA802_0
(GLUTAMATE RECEPTOR 2)		5j39 TUDOR AND KH
DOMAIN-CONTAINING
PROTEIN
(Homo
sapiens)		3 / 3ASP A 393
ASN A 394
SER A 313
CAC  A 501 (-3.6A)
None
None
0.85A23.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LSL_A_PZIA802_0
(GLUTAMATE RECEPTOR 2)		5nem INTEGRIN BETA-6
(Homo
sapiens)		3 / 3ASP B 127
ASN B 130
SER B 124
None
0.95A18.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LSL_A_PZIA802_0
(GLUTAMATE RECEPTOR 2)		5u1d ANTIGEN PEPTIDE
TRANSPORTER 1
ANTIGEN PEPTIDE
TRANSPORTER 2
TAP TRANSPORTER
INHIBITOR ICP47
(Homo
sapiens;
Homo
sapiens;
Human
alphaherpesvirus
1)		3 / 3ASP X   9
ASN B 269
SER A 412
None
0.96A18.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LSL_D_PZID800_0
(GLUTAMATE RECEPTOR 2)		1nst HEPARAN SULFATE
N-DEACETYLASE/N-SULF
OTRANSFERASE
(Homo
sapiens)		4 / 7SER A 632
TYR A 804
MET A 626
LEU A 624
None
1.43A21.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LSL_D_PZID800_0
(GLUTAMATE RECEPTOR 2)		1ohe CDC14B2 PHOSPHATASE
(Homo
sapiens)		4 / 7TYR A 248
ASN A 217
LEU A 216
ASP A 215
None
1.40A22.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LSL_D_PZID800_0
(GLUTAMATE RECEPTOR 2)		2cw9 TRANSLOCASE OF INNER
MITOCHONDRIAL
MEMBRANE
(Homo
sapiens)		4 / 7TYR A 348
LEU A 336
ASP A 337
LYS A 340
None
0.91A21.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LSL_D_PZID800_0
(GLUTAMATE RECEPTOR 2)		2lll LAMIN-B2
(Homo
sapiens)		4 / 7SER A 453
TYR A 501
ASN A 470
LEU A 503
None
1.44A22.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LSL_D_PZID800_0
(GLUTAMATE RECEPTOR 2)		2wtk STE20-RELATED KINASE
ADAPTER PROTEIN
ALPHA
(Homo
sapiens)		4 / 7SER B 195
TYR B 133
ASN B 217
LEU B 214
None
1.43A21.11
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3LSL_D_PZID800_0
(GLUTAMATE RECEPTOR 2)		2zns GLUTAMATE RECEPTOR,
IONOTROPIC KAINATE 1
(Homo
sapiens)		4 / 7TYR A 448
MET A 519
LEU A 776
LYS A 780
None
0.43A51.92
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3LSL_D_PZID800_0
(GLUTAMATE RECEPTOR 2)		3qxm GLUTAMATE RECEPTOR
IONOTROPIC, KAINATE
2
(Homo
sapiens)		4 / 7TYR A 431
MET A 503
LEU A 760
LYS A 764
None
0.48A51.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LSL_D_PZID800_0
(GLUTAMATE RECEPTOR 2)		3w1g DNA LIGASE 4
(Homo
sapiens)		4 / 7TYR A  82
ASN A 149
LEU A 152
ASP A 153
None
1.21A17.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LSL_D_PZID800_0
(GLUTAMATE RECEPTOR 2)		4erv RYANODINE RECEPTOR 3
(Homo
sapiens)		4 / 7SER A2625
TYR A2743
LEU A2787
ASP A2786
None
1.41A21.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LSL_D_PZID800_0
(GLUTAMATE RECEPTOR 2)		4htp DNA LIGASE 4
(Homo
sapiens)		4 / 7TYR A  82
ASN A 149
LEU A 152
ASP A 153
None
1.15A20.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LSL_D_PZID800_0
(GLUTAMATE RECEPTOR 2)		4qgu GAMMA-INTERFERON-IND
UCIBLE PROTEIN 16
(Homo
sapiens)		4 / 7TYR A 218
ASN A 274
LEU A 245
LYS A 226
None
1.27A19.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LSL_D_PZID800_0
(GLUTAMATE RECEPTOR 2)		5fww KREMEN PROTEIN 1
DICKKOPF-RELATED
PROTEIN 1
(Homo
sapiens;
Homo
sapiens)		4 / 7SER C 193
TYR B 165
LEU C 190
LYS C 208
None
1.32A13.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LSL_D_PZID800_0
(GLUTAMATE RECEPTOR 2)		5lt1 KINESIN-LIKE PROTEIN
(Homo
sapiens)		4 / 7TYR A 118
ASN A 216
LEU A 126
ASP A 123
None
1.11A22.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LSL_D_PZID800_0
(GLUTAMATE RECEPTOR 2)		5m8t 5,6-DIHYDROXYINDOLE-
2-CARBOXYLIC ACID
OXIDASE
(Homo
sapiens)		4 / 7TYR A 185
LEU A 148
ASP A 149
LYS A 152
None
1.34A20.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LSL_D_PZID800_0
(GLUTAMATE RECEPTOR 2)		6bnl NKT VALPHA14 (MOUSE)
- 2C12 TCR - HYBRID
MOUSE VARIABLE AND
HUMAN CONSTANT
DOMAINS
(Homo
sapiens)		4 / 7TYR C  24
LEU C  66
ASP C  67
LYS C  71
None
1.45Aundetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LSL_D_PZID801_0
(GLUTAMATE RECEPTOR 2)		1hxm GAMMA-DELTA T-CELL
RECEPTOR
(Homo
sapiens)		4 / 8ASN A 176
ILE A 169
PRO A 119
GLY A 173
None
0.90A21.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LSL_D_PZID801_0
(GLUTAMATE RECEPTOR 2)		1uap PROCOLLAGEN
C-PROTEINASE
ENHANCER PROTEIN
(Homo
sapiens)		4 / 8SER A  24
PRO A 125
SER A  48
GLY A 114
None
0.96A19.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LSL_D_PZID801_0
(GLUTAMATE RECEPTOR 2)		2c11 MEMBRANE COPPER
AMINE OXIDASE
(Homo
sapiens)		4 / 8PRO A 653
SER A 620
PRO A 215
GLY A 217
None
0.85A15.31
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3LSL_D_PZID801_0
(GLUTAMATE RECEPTOR 2)		2zns GLUTAMATE RECEPTOR,
IONOTROPIC KAINATE 1
(Homo
sapiens)		4 / 8ILE A 504
PRO A 517
SER A 746
GLY A 748
None
0.23A51.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LSL_D_PZID801_0
(GLUTAMATE RECEPTOR 2)		3a1f CYTOCHROME B-245
HEAVY CHAIN
(Homo
sapiens)		4 / 8SER A  38
ILE A   1
SER A  11
GLY A   8
None
NI  A 193 (-4.0A)
None
None
0.85A20.46
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3LSL_D_PZID801_0
(GLUTAMATE RECEPTOR 2)		3qxm GLUTAMATE RECEPTOR
IONOTROPIC, KAINATE
2
(Homo
sapiens)		4 / 8ILE A 488
PRO A 501
SER A 730
GLY A 732
None
0.28A51.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LSL_D_PZID801_0
(GLUTAMATE RECEPTOR 2)		4j1y COMPLEMENT C1S
SUBCOMPONENT
(Homo
sapiens)		5 / 8PRO A 373
SER A 380
ILE A 361
PRO A 362
GLY A 360
None
1.31A22.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LSL_D_PZID801_0
(GLUTAMATE RECEPTOR 2)		4lr2 BIS(5'-ADENOSYL)-TRI
PHOSPHATASE ENPP4
(Homo
sapiens)		4 / 8PRO A  47
ASN A  51
ILE A 214
GLY A 215
None
0.93A20.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LSL_D_PZID802_0
(GLUTAMATE RECEPTOR 2)		2kxn TRANSFORMER-2
PROTEIN HOMOLOG BETA
(Homo
sapiens)		3 / 3SER B 194
ASP B 192
ASN B 180
 G  A   3 ( 2.3A)
None
None
0.98A19.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LSL_D_PZID802_0
(GLUTAMATE RECEPTOR 2)		2wnp FICOLIN-1
(Homo
sapiens)		3 / 3SER F 239
ASP F 235
ASN F 225
None
CA  F1298 (-2.6A)
None
0.69A21.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LSL_D_PZID802_0
(GLUTAMATE RECEPTOR 2)		3jwo HIV-1 GP120 ENVELOPE
GLYCOPROTEIN
(Homo
sapiens)		3 / 3SER A 365
ASP A 457
ASN A 462
None
0.61A20.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LSL_D_PZID802_0
(GLUTAMATE RECEPTOR 2)		3ojy COMPLEMENT COMPONENT
C8 BETA CHAIN
(Homo
sapiens)		3 / 3SER B 232
ASP B 491
ASN B 515
None
0.80A19.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LSL_D_PZID802_0
(GLUTAMATE RECEPTOR 2)		4lnz UNCONVENTIONAL
MYOSIN-VB
(Homo
sapiens)		3 / 3SER A1564
ASP A1513
ASN A1516
None
0.85A20.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LSL_D_PZID802_0
(GLUTAMATE RECEPTOR 2)		4mqt MUSCARINIC
ACETYLCHOLINE
RECEPTOR M2
NANOBODY 9-8
(Homo
sapiens;
Lama
glama)		3 / 3SER A 380
ASP B  33
ASN B  77
None
0.83A23.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LSL_D_PZID802_0
(GLUTAMATE RECEPTOR 2)		4zdl O-PHOSPHOSERYL-TRNA(
SEC) SELENIUM
TRANSFERASE
(Homo
sapiens)		3 / 3SER A 112
ASP A  62
ASN A  64
None
0.81A20.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LSL_D_PZID802_0
(GLUTAMATE RECEPTOR 2)		5j39 TUDOR AND KH
DOMAIN-CONTAINING
PROTEIN
(Homo
sapiens)		3 / 3SER A 313
ASP A 393
ASN A 394
None
CAC  A 501 (-3.6A)
None
0.84A23.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LSL_D_PZID802_0
(GLUTAMATE RECEPTOR 2)		5lsp HEPATOCYTE GROWTH
FACTOR RECEPTOR
(Homo
sapiens)		3 / 3SER A 525
ASP A 587
ASN A 642
None
0.95A20.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LSL_D_PZID802_0
(GLUTAMATE RECEPTOR 2)		5nem INTEGRIN BETA-6
(Homo
sapiens)		3 / 3SER B 124
ASP B 127
ASN B 130
None
0.91A18.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LSL_G_PZIG800_0
(GLUTAMATE RECEPTOR 2)		1hjv CHITINASE-3 LIKE
PROTEIN 1
(Homo
sapiens)		4 / 6TYR A  28
ASN A  72
LEU A  76
ASP A  73
None
1.24A22.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LSL_G_PZIG800_0
(GLUTAMATE RECEPTOR 2)		1ohe CDC14B2 PHOSPHATASE
(Homo
sapiens)		4 / 6TYR A 248
ASN A 217
LEU A 216
ASP A 215
None
1.35A22.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LSL_G_PZIG800_0
(GLUTAMATE RECEPTOR 2)		2o8e DNA MISMATCH REPAIR
PROTEIN MSH6
(Homo
sapiens)		4 / 6TYR B1159
ASN B 789
LEU B 792
ASP B 793
None
1.34A12.90
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3LSL_G_PZIG800_0
(GLUTAMATE RECEPTOR 2)		2zns GLUTAMATE RECEPTOR,
IONOTROPIC KAINATE 1
(Homo
sapiens)		4 / 6TYR A 448
MET A 519
LEU A 776
LYS A 780
None
0.40A51.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LSL_G_PZIG800_0
(GLUTAMATE RECEPTOR 2)		3j0k DNA-DIRECTED RNA
POLYMERASE II 19 KDA
POLYPEPTIDE
(Homo
sapiens)		4 / 6TYR G  74
ASN G  10
LEU G   9
LYS G  73
None
1.43A21.24
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3LSL_G_PZIG800_0
(GLUTAMATE RECEPTOR 2)		3qxm GLUTAMATE RECEPTOR
IONOTROPIC, KAINATE
2
(Homo
sapiens)		4 / 6TYR A 431
MET A 503
LEU A 760
LYS A 764
None
0.39A51.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LSL_G_PZIG800_0
(GLUTAMATE RECEPTOR 2)		3t0o RIBONUCLEASE T2
(Homo
sapiens)		4 / 6TYR A 176
ASN A 148
LEU A 147
ASP A 146
None
1.34A19.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LSL_G_PZIG800_0
(GLUTAMATE RECEPTOR 2)		3thw DNA MISMATCH REPAIR
PROTEIN MSH3
(Homo
sapiens)		4 / 6TYR B 912
ASN B 582
LEU B 585
ASP B 586
None
1.31A14.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LSL_G_PZIG800_0
(GLUTAMATE RECEPTOR 2)		3w1g DNA LIGASE 4
(Homo
sapiens)		4 / 6TYR A  82
ASN A 149
LEU A 152
ASP A 153
None
1.19A17.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LSL_G_PZIG800_0
(GLUTAMATE RECEPTOR 2)		4htp DNA LIGASE 4
(Homo
sapiens)		4 / 6TYR A  82
ASN A 149
LEU A 152
ASP A 153
None
1.14A20.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LSL_G_PZIG800_0
(GLUTAMATE RECEPTOR 2)		4qgu GAMMA-INTERFERON-IND
UCIBLE PROTEIN 16
(Homo
sapiens)		4 / 6TYR A 218
ASN A 274
LEU A 245
LYS A 226
None
1.23A19.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LSL_G_PZIG800_0
(GLUTAMATE RECEPTOR 2)		5m8t 5,6-DIHYDROXYINDOLE-
2-CARBOXYLIC ACID
OXIDASE
(Homo
sapiens)		4 / 6TYR A 185
LEU A 148
ASP A 149
LYS A 152
None
1.34A20.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LSL_G_PZIG800_0
(GLUTAMATE RECEPTOR 2)		6bnl NKT VALPHA14 (MOUSE)
- 2C12 TCR - HYBRID
MOUSE VARIABLE AND
HUMAN CONSTANT
DOMAINS
(Homo
sapiens)		4 / 6TYR C  24
LEU C  66
ASP C  67
LYS C  71
None
1.46Aundetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LSL_G_PZIG801_0
(GLUTAMATE RECEPTOR 2)		1a6a HLA CLASS II
HISTOCOMPATIBILITY
ANTIGEN, DR ALPHA
CHAIN
(Homo
sapiens)		3 / 3PRO A 152
SER A 133
ASN A  94
None
0.94A22.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LSL_G_PZIG801_0
(GLUTAMATE RECEPTOR 2)		1icf PROTEIN (INVARIANT
CHAIN)
(Homo
sapiens)		3 / 3PRO I 239
SER I 258
ASN I 221
None
0.90A10.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LSL_G_PZIG801_0
(GLUTAMATE RECEPTOR 2)		1n76 LACTOFERRIN
(Homo
sapiens)		3 / 3PRO A 519
SER A 375
ASN A 515
None
0.93A17.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LSL_G_PZIG801_0
(GLUTAMATE RECEPTOR 2)		1p49 STERYL-SULFATASE
(Homo
sapiens)		3 / 3PRO A 379
SER A 341
ASN A 361
None
0.91A18.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LSL_G_PZIG801_0
(GLUTAMATE RECEPTOR 2)		1tpg T-PLASMINOGEN
ACTIVATOR F1-G
(Homo
sapiens)		3 / 3PRO A  47
SER A  45
ASN A  29
None
0.90A16.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LSL_G_PZIG801_0
(GLUTAMATE RECEPTOR 2)		2f8a GLUTATHIONE
PEROXIDASE 1
(Homo
sapiens)		3 / 3PRO A  75
SER A  45
ASN A  77
None
0.87A21.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LSL_G_PZIG801_0
(GLUTAMATE RECEPTOR 2)		2he3 GLUTATHIONE
PEROXIDASE 2
(Homo
sapiens)		3 / 3PRO A  67
SER A  38
ASN A  69
None
0.82A20.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LSL_G_PZIG801_0
(GLUTAMATE RECEPTOR 2)		2v55 RHO-ASSOCIATED
PROTEIN KINASE 1
(Homo
sapiens)		3 / 3PRO A 393
SER A 118
ASN A 390
None
0.90A22.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LSL_G_PZIG801_0
(GLUTAMATE RECEPTOR 2)		3ld8 BIFUNCTIONAL
ARGININE DEMETHYLASE
AND
LYSYL-HYDROXYLASE
JMJD6
(Homo
sapiens)		3 / 3PRO A 171
SER A 135
ASN A 287
None
SO4  A 343 ( 4.9A)
None
0.86A22.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LSL_G_PZIG801_0
(GLUTAMATE RECEPTOR 2)		4fdj N-ACETYLGALACTOSAMIN
E-6-SULFATASE
(Homo
sapiens)		3 / 3PRO A 321
SER A 287
ASN A 303
None
0.92A17.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LSL_G_PZIG801_0
(GLUTAMATE RECEPTOR 2)		5epg ALDEHYDE OXIDASE
(Homo
sapiens)		3 / 3PRO A  70
SER A 124
ASN A  72
None
None
FES  A3002 ( 3.8A)
0.69A12.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LSL_G_PZIG801_0
(GLUTAMATE RECEPTOR 2)		5mra SORCIN
(Homo
sapiens)		3 / 3PRO A 122
SER A 149
ASN A 142
None
0.92A20.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LSL_G_PZIG801_0
(GLUTAMATE RECEPTOR 2)		5nug CYTOPLASMIC DYNEIN 1
HEAVY CHAIN 1
(Homo
sapiens)		3 / 3PRO A3568
SER A3707
ASN A3576
None
0.89A4.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LSL_G_PZIG801_0
(GLUTAMATE RECEPTOR 2)		5viy 8ANC195 G52K5 FAB
HEAVY CHAIN
(Homo
sapiens)		3 / 3PRO K  14
SER K  84
ASN K  82
None
0.89A21.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LSL_G_PZIG801_0
(GLUTAMATE RECEPTOR 2)		5w2l CST COMPLEX SUBUNIT
CTC1
(Homo
sapiens)		3 / 3PRO A 842
SER A 762
ASN A 745
None
0.90A20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LSL_G_PZIG801_0
(GLUTAMATE RECEPTOR 2)		6cpl HLA CLASS II
HISTOCOMPATIBILITY
ANTIGEN, DR ALPHA
CHAIN
(Homo
sapiens)		3 / 3PRO A 152
SER A 133
ASN A  94
None
0.84Aundetectable