POTENTIAL TARGETS FROM HUMAN (RESULTS FROM SUB-STRUCTURAL SIMILARITY SEARCHES)
1) User may click on the DrReposER ID (the second column) to get information on the binding sites and drug molecule.
2) Click View (the second last column) to view matched residues and superposition in the NGL viewer (upper right part).
3) User may also click on the Dock (the last column) to get script for molecular docking in UCSF Chimera through AutoDock Vina.

DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZMB_A_PXBA692_1
(LACTOTRANSFERRIN)		1elv COMPLEMENT C1S
COMPONENT
(Homo
sapiens)		3 / 3PRO A 347
GLU A 385
TYR A 369
None
0.66A22.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZMB_A_PXBA692_1
(LACTOTRANSFERRIN)		1qub PROTEIN (HUMAN
BETA2-GLYCOPROTEIN
I)
(Homo
sapiens)		3 / 3PRO A  17
GLU A  23
TYR A  22
None
0.70A24.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZMB_A_PXBA692_1
(LACTOTRANSFERRIN)		2a7l HYPOTHETICAL
UBIQUITIN-CONJUGATIN
G ENZYME LOC55284
(Homo
sapiens)		3 / 3PRO A  79
GLU A  50
TYR A  49
None
0.75A14.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZMB_A_PXBA692_1
(LACTOTRANSFERRIN)		2dat POSSIBLE GLOBAL
TRANSCRIPTION
ACTIVATOR SNF2L2
(Homo
sapiens)		3 / 3PRO A  44
GLU A  54
TYR A  53
None
0.80A15.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZMB_A_PXBA692_1
(LACTOTRANSFERRIN)		2df0 PEPTIDE YY
(Homo
sapiens)		3 / 3PRO A   3
GLU A  14
TYR A  18
None
0.63A6.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZMB_A_PXBA692_1
(LACTOTRANSFERRIN)		2dl5 KIAA0769 PROTEIN
(Homo
sapiens)		3 / 3PRO A  63
GLU A  33
TYR A  22
None
0.78A13.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZMB_A_PXBA692_1
(LACTOTRANSFERRIN)		2eqs ATP-DEPENDENT RNA
HELICASE DHX8
(Homo
sapiens)		3 / 3PRO A 262
GLU A 285
TYR A 268
None
0.60A16.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZMB_A_PXBA692_1
(LACTOTRANSFERRIN)		2lkm MORTALITY FACTOR
4-LIKE PROTEIN 1
(Homo
sapiens)		3 / 3PRO B 240
GLU B 317
TYR B 318
None
0.78A19.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZMB_A_PXBA692_1
(LACTOTRANSFERRIN)		2mt6 UBIQUITIN-CONJUGATIN
G ENZYME E2 W
(Homo
sapiens)		3 / 3PRO A  79
GLU A  50
TYR A  49
None
0.81A18.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZMB_A_PXBA692_1
(LACTOTRANSFERRIN)		2na2 RIBONUCLEASE 3
(Homo
sapiens)		3 / 3PRO A  27
GLU A  52
TYR A  48
None
0.65A13.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZMB_A_PXBA692_1
(LACTOTRANSFERRIN)		3iu5 PROTEIN POLYBROMO-1
(Homo
sapiens)		3 / 3PRO A  91
GLU A  86
TYR A  84
None
0.73A15.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZMB_A_PXBA692_1
(LACTOTRANSFERRIN)		3q5e ATLASTIN-1
(Homo
sapiens)		3 / 3PRO A 208
GLU A 195
TYR A 196
None
0.76A21.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZMB_A_PXBA692_1
(LACTOTRANSFERRIN)		3qt2 INTERLEUKIN-5
RECEPTOR SUBUNIT
ALPHA
(Homo
sapiens)		3 / 3PRO A  13
GLU A  58
TYR A  45
None
0.64A20.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZMB_A_PXBA692_1
(LACTOTRANSFERRIN)		3v5q NT-3 GROWTH FACTOR
RECEPTOR
(Homo
sapiens)		3 / 3PRO A 792
GLU A 798
TYR A 800
None
0.81A22.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZMB_A_PXBA692_1
(LACTOTRANSFERRIN)		4cns DIHYDROPYRIMIDINASE-
LIKE 3
(Homo
sapiens)		3 / 3PRO A 306
GLU A 221
TYR A 290
None
0.73A20.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZMB_A_PXBA692_1
(LACTOTRANSFERRIN)		4cnt DIHYDROPYRIMIDINASE-
LIKE 3
(Homo
sapiens)		3 / 3PRO A 306
GLU A 221
TYR A 290
None
0.79A19.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZMB_A_PXBA692_1
(LACTOTRANSFERRIN)		4n49 CAP-SPECIFIC MRNA
(NUCLEOSIDE-2'-O-)-M
ETHYLTRANSFERASE 1
(Homo
sapiens)		3 / 3PRO A 149
GLU A 225
TYR A 224
None
0.64A20.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZMB_A_PXBA692_1
(LACTOTRANSFERRIN)		4ova FRAGILE X MENTAL
RETARDATION PROTEIN
1
(Homo
sapiens)		3 / 3PRO A  76
GLU A   7
TYR A  16
None
0.79A20.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZMB_A_PXBA692_1
(LACTOTRANSFERRIN)		4wgk NEUTRAL CERAMIDASE
(Homo
sapiens)		3 / 3PRO A 501
GLU A 585
TYR A 586
None
0.67A19.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZMB_A_PXBA692_1
(LACTOTRANSFERRIN)		4wqo CULLIN-2
(Homo
sapiens)		3 / 3PRO D   5
GLU D  51
TYR D  49
None
0.76A17.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZMB_A_PXBA692_1
(LACTOTRANSFERRIN)		4y97 DNA POLYMERASE ALPHA
CATALYTIC SUBUNIT
(Homo
sapiens)		3 / 3PRO B1305
GLU B1402
TYR B1430
None
0.73A19.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZMB_A_PXBA692_1
(LACTOTRANSFERRIN)		5iz5 CYTOSOLIC
PHOSPHOLIPASE A2
DELTA
(Homo
sapiens)		3 / 3PRO B 765
GLU B 775
TYR B 773
None
0.81A18.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZMB_A_PXBA692_1
(LACTOTRANSFERRIN)		5nks DIHYDROPYRIMIDINASE-
RELATED PROTEIN 4
(Homo
sapiens)		3 / 3PRO A 306
GLU A 221
TYR A 290
PRO  A 306 ( 1.1A)
GLU  A 221 ( 0.6A)
TYR  A 290 ( 1.3A)
0.79A20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZMB_A_PXBA692_1
(LACTOTRANSFERRIN)		5nug CYTOPLASMIC DYNEIN 1
HEAVY CHAIN 1
(Homo
sapiens)		3 / 3PRO A2527
GLU A2538
TYR A2537
None
0.71A5.79