POTENTIAL TARGETS FROM HUMAN (RESULTS FROM SUB-STRUCTURAL SIMILARITY SEARCHES)
1) User may click on the DrReposER ID (the second column) to get information on the binding sites and drug molecule.
2) Click View (the second last column) to view matched residues and superposition in the NGL viewer (upper right part).
3) User may also click on the Dock (the last column) to get script for molecular docking in UCSF Chimera through AutoDock Vina.

DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1BCU_H_PRLH280_0
(ALPHA-THROMBIN)		1elv COMPLEMENT C1S
COMPONENT
(Homo
sapiens)		6 / 9ASP A 611
SER A 617
VAL A 638
TRP A 640
GLY A 641
GLY A 648
None
SO4  A2001 ( 2.7A)
None
None
None
None
0.40A28.29
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1BCU_H_PRLH280_0
(ALPHA-THROMBIN)		1fxy COAGULATION FACTOR
XA-TRYPSIN CHIMERA
(Homo
sapiens)		6 / 9ASP A 189
SER A 195
VAL A 213
TRP A 215
GLY A 216
GLY A 226
0G6  A   1 (-2.8A)
0G6  A   1 (-1.4A)
None
None
0G6  A   1 (-3.9A)
0G6  A   1 (-3.3A)
0.47A37.21
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1BCU_H_PRLH280_0
(ALPHA-THROMBIN)		1gvl KALLIKREIN 6
(Homo
sapiens)		5 / 9SER A 195
VAL A 213
TRP A 215
GLY A 216
GLY A 226
None
0.70A37.45
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1BCU_H_PRLH280_0
(ALPHA-THROMBIN)		1h4w TRYPSIN IVA
(Homo
sapiens)		6 / 9ASP A 189
SER A 195
VAL A 213
TRP A 215
GLY A 216
GLY A 226
BEN  A 250 (-2.9A)
BEN  A 250 (-3.6A)
None
None
BEN  A 250 (-3.9A)
BEN  A 250 (-3.3A)
0.32A37.21
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1BCU_H_PRLH280_0
(ALPHA-THROMBIN)		1o5f SERINE PROTEASE
HEPSIN
(Homo
sapiens)		7 / 9ASP H 189
ALA H 190
SER H 195
VAL H 213
TRP H 215
GLY H 216
GLY H 226
CR9  H 256 (-2.4A)
CR9  H 256 (-2.9A)
CR9  H 256 (-1.5A)
CR9  H 256 (-4.3A)
None
CR9  H 256 ( 3.8A)
CR9  H 256 (-3.0A)
0.32A40.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1BCU_H_PRLH280_0
(ALPHA-THROMBIN)		1q3x MANNAN-BINDING
LECTIN SERINE
PROTEASE 2
(Homo
sapiens)		6 / 9ASP A 627
SER A 633
VAL A 653
TRP A 655
GLY A 656
GLY A 667
 NA  A 800 ( 4.6A)
GOL  A 701 (-3.0A)
GOL  A 701 (-4.9A)
None
GOL  A 701 ( 4.1A)
GOL  A 701 ( 4.0A)
0.43A28.95
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1BCU_H_PRLH280_0
(ALPHA-THROMBIN)		1zlr COAGULATION FACTOR
XI
(Homo
sapiens)		6 / 9ASP A 189
ALA A 190
SER A 195
TRP A 215
GLY A 216
GLY A 226
368  A 901 (-2.8A)
368  A 901 (-3.7A)
368  A 901 (-1.4A)
None
368  A 901 (-3.6A)
368  A 901 (-3.5A)
0.32A37.02
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1BCU_H_PRLH280_0
(ALPHA-THROMBIN)		2ei8 COAGULATION FACTOR
X, HEAVY CHAIN
(Homo
sapiens)		7 / 9ASP A 189
ALA A 190
SER A 195
VAL A 213
TRP A 215
GLY A 216
GLY A 226
DT8  A 700 (-3.5A)
DT8  A 700 (-3.6A)
DT8  A 700 ( 3.9A)
DT8  A 700 ( 4.1A)
DT8  A 700 (-3.9A)
DT8  A 700 (-3.5A)
DT8  A 700 (-3.5A)
0.31A40.77
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1BCU_H_PRLH280_0
(ALPHA-THROMBIN)		2ei8 COAGULATION FACTOR
X, HEAVY CHAIN
(Homo
sapiens)		5 / 9ASP A 189
ALA A 190
VAL A 138
GLY A 226
GLY A 184
DT8  A 700 (-3.5A)
DT8  A 700 (-3.6A)
None
DT8  A 700 (-3.5A)
None
1.23A40.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1BCU_H_PRLH280_0
(ALPHA-THROMBIN)		2opu KHSRP PROTEIN
(Homo
sapiens)		5 / 9ALA A  79
GLU A  22
VAL A  53
GLY A  71
GLY A  50
None
1.09A15.97
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1BCU_H_PRLH280_0
(ALPHA-THROMBIN)		2oq5 TRANSMEMBRANE
PROTEASE, SERINE 11E
(Homo
sapiens)		7 / 9ASP A 189
ALA A 190
SER A 195
VAL A 213
TRP A 215
GLY A 216
GLY A 226
BEN  A 245 (-3.0A)
BEN  A 245 (-3.9A)
BEN  A 245 (-3.3A)
None
None
BEN  A 245 ( 3.8A)
BEN  A 245 (-3.4A)
0.34A37.31
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1BCU_H_PRLH280_0
(ALPHA-THROMBIN)		2pks THROMBIN HEAVY CHAIN
FRAGMENT
(Homo
sapiens)		5 / 9ALA C 230
GLU C 232
SER C 235
VAL C 255
TRP C 257
G44  C 101 (-3.8A)
None
G44  C 101 (-3.5A)
None
G44  C 101 (-4.1A)
0.85A100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1BCU_H_PRLH280_0
(ALPHA-THROMBIN)		2pks THROMBIN HEAVY CHAIN
FRAGMENT
(Homo
sapiens)		7 / 9ASP C 229
ALA C 230
SER C 235
VAL C 255
TRP C 257
GLY C 258
GLY C 268
G44  C 101 (-2.6A)
G44  C 101 (-3.8A)
G44  C 101 (-3.5A)
None
G44  C 101 (-4.1A)
G44  C 101 (-3.3A)
G44  C 101 (-3.0A)
0.27A100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1BCU_H_PRLH280_0
(ALPHA-THROMBIN)		2psy KALLIKREIN-5
(Homo
sapiens)		6 / 9ASP A 189
SER A 195
VAL A 213
TRP A 215
GLY A 216
GLY A 226
None
0.42A34.87
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1BCU_H_PRLH280_0
(ALPHA-THROMBIN)		2qy0 COMPLEMENT C1R
SUBCOMPONENT
(Homo
sapiens)		7 / 9ASP B 631
ALA B 632
SER B 637
VAL B 657
TRP B 659
GLY B 660
GLY B 668
None
0.37A38.15
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1BCU_H_PRLH280_0
(ALPHA-THROMBIN)		2r0l HEPATOCYTE GROWTH
FACTOR ACTIVATOR
(Homo
sapiens)		6 / 9ASP A 189
ALA A 190
SER A 195
TRP A 215
GLY A 216
GLY A 226
None
0.39A35.07
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1BCU_H_PRLH280_0
(ALPHA-THROMBIN)		2r2w PLASMINOGEN
ACTIVATOR, UROKINASE
(Homo
sapiens)		5 / 9ASP U 189
VAL U 213
TRP U 215
GLY U 216
GLY U 226
4PG  U 300 (-2.8A)
None
None
4PG  U 300 (-3.3A)
4PG  U 300 (-3.2A)
0.40A32.12
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1BCU_H_PRLH280_0
(ALPHA-THROMBIN)		2wpm COAGULATION FACTOR
IXA HEAVY CHAIN
(Homo
sapiens)		5 / 9ASP S 189
SER S 195
TRP S 215
GLY S 216
GLY S 226
None
0.45A37.74
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1BCU_H_PRLH280_0
(ALPHA-THROMBIN)		2zec TRYPTASE BETA 2
(Homo
sapiens)		6 / 9ASP A 203
SER A 209
VAL A 227
TRP A 229
GLY A 230
GLY A 240
11N  A   1 (-2.6A)
11N  A   1 (-3.3A)
None
None
11N  A   1 (-3.9A)
11N  A   1 (-3.6A)
0.52A35.69
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1BCU_H_PRLH280_0
(ALPHA-THROMBIN)		3f6u VITAMIN K-DEPENDENT
PROTEIN C HEAVY
CHAIN
(Homo
sapiens)		7 / 9ASP H 189
ALA H 190
SER H 195
VAL H 213
TRP H 215
GLY H 216
GLY H 226
0G6  H   1 (-2.8A)
0G6  H   1 (-3.4A)
0G6  H   1 (-1.8A)
None
0G6  H   1 (-4.1A)
0G6  H   1 (-3.8A)
0G6  H   1 ( 3.9A)
0.37A40.23
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1BCU_H_PRLH280_0
(ALPHA-THROMBIN)		3gov MASP-1
(Homo
sapiens)		7 / 9ASP B 640
ALA B 641
SER B 646
VAL B 666
TRP B 668
GLY B 669
GLY B 679
None
0.38A36.56
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1BCU_H_PRLH280_0
(ALPHA-THROMBIN)		3gym PROSTASIN
(Homo
sapiens)		7 / 9ASP A 189
ALA A 190
SER A 195
VAL A 213
TRP A 215
GLY A 216
GLY A 226
None
0.39A36.56
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1BCU_H_PRLH280_0
(ALPHA-THROMBIN)		3r3g THROMBIN HEAVY CHAIN
(Homo
sapiens)		7 / 9ASP B 189
ALA B 190
SER B 195
VAL B 213
TRP B 215
GLY B 216
GLY B 226
None
0.16A97.68
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1BCU_H_PRLH280_0
(ALPHA-THROMBIN)		4fxg MANNAN-BINDING
LECTIN SERINE
PROTEASE 2 B CHAIN
(Homo
sapiens)		5 / 9ASP H 627
VAL H 653
TRP H 655
GLY H 656
GLY H 667
None
0.37A35.23
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1BCU_H_PRLH280_0
(ALPHA-THROMBIN)		4iw4 MANNAN-BINDING
LECTIN SERINE
PROTEASE 3
(Homo
sapiens)		6 / 9ASP E 639
SER E 645
VAL E 665
TRP E 667
GLY E 668
GLY E 680
None
0.58A35.17
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1BCU_H_PRLH280_0
(ALPHA-THROMBIN)		4k8y KALLIKREIN-4
(Homo
sapiens)		5 / 9ASP A 189
SER A 195
VAL A 213
GLY A 216
GLY A 226
None
0.44A35.25
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1BCU_H_PRLH280_0
(ALPHA-THROMBIN)		4r0i SUPPRESSOR OF
TUMORIGENICITY 14
PROTEIN
(Homo
sapiens)		6 / 9ASP A 189
SER A 195
VAL A 213
TRP A 215
GLY A 216
GLY A 226
3KM  A 900 (-2.9A)
3KM  A 900 (-3.6A)
None
None
3KM  A 900 (-3.4A)
3KM  A 900 (-3.2A)
0.32A35.50
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1BCU_H_PRLH280_0
(ALPHA-THROMBIN)		4wwy TRYPSIN-1
(Homo
sapiens)		6 / 9ASP A 189
SER A 195
VAL A 213
TRP A 215
GLY A 216
GLY A 226
None
0.43A36.43
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1BCU_H_PRLH280_0
(ALPHA-THROMBIN)		4ylq COAGULATION FACTOR
VII
(Homo
sapiens)		6 / 9ASP H 189
SER H 195
VAL H 213
TRP H 215
GLY H 216
GLY H 226
0Z7  H 501 (-2.3A)
0Z7  H 501 (-1.4A)
0Z7  H 501 ( 4.7A)
TMA  H 508 ( 3.9A)
0Z7  H 501 (-3.4A)
0Z7  H 501 (-3.0A)
0.41A35.74
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1BCU_H_PRLH280_0
(ALPHA-THROMBIN)		5brr TISSUE-TYPE
PLASMINOGEN
ACTIVATOR
(Homo
sapiens)		5 / 9ASP E 189
ALA E 190
TRP E 215
GLY E 216
GLY E 226
None
0.35A32.38
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1BCU_H_PRLH280_0
(ALPHA-THROMBIN)		5f8z PLASMA KALLIKREIN
LIGHT CHAIN
(Homo
sapiens)		6 / 9ASP A 189
ALA A 190
SER A 195
TRP A 215
GLY A 216
GLY A 226
None
0.51A39.70
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1BCU_H_PRLH280_0
(ALPHA-THROMBIN)		5fah KALLIKREIN-7
(Homo
sapiens)		5 / 9ALA A 190
SER A 195
VAL A 213
TRP A 215
GLY A 226
5VT  A 302 (-3.8A)
5VT  A 302 (-4.0A)
None
None
5VT  A 302 ( 4.3A)
0.88A33.97
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1BCU_H_PRLH280_0
(ALPHA-THROMBIN)		5fah KALLIKREIN-7
(Homo
sapiens)		5 / 9ALA A 190
VAL A 213
TRP A 215
GLY A 216
GLY A 226
5VT  A 302 (-3.8A)
None
None
5VT  A 302 (-3.4A)
5VT  A 302 ( 4.3A)
0.44A33.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1BCU_H_PRLH280_0
(ALPHA-THROMBIN)		5ms3 KALLIKREIN-8
(Homo
sapiens)		5 / 9ASP A 189
SER A 195
TRP A 215
GLY A 216
GLY A 226
None
0.28Aundetectable
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1BCU_H_PRLH280_0
(ALPHA-THROMBIN)		5o32 COMPLEMENT FACTOR I
(Homo
sapiens)		6 / 9ASP I 519
ALA I 520
VAL I 544
TRP I 546
GLY I 547
GLY I 557
None
0.94A33.09
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1BCU_H_PRLH280_0
(ALPHA-THROMBIN)		5to3 PROTHROMBIN,THROMBOM
ODULIN
(Homo
sapiens)		5 / 9ASP B 214
ALA B 215
GLU B 217
GLY B 243
GLY B 253
0G6  B 501 (-2.9A)
0G6  B 501 (-3.4A)
0G6  B 501 (-3.8A)
0G6  B 501 (-3.7A)
0G6  B 501 (-3.6A)
0.86A88.62
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1BCU_H_PRLH280_0
(ALPHA-THROMBIN)		5to3 PROTHROMBIN,THROMBOM
ODULIN
(Homo
sapiens)		6 / 9ASP B 214
ALA B 215
SER B 220
VAL B 240
GLY B 243
GLY B 253
0G6  B 501 (-2.9A)
0G6  B 501 (-3.4A)
0G6  B 501 (-1.3A)
None
0G6  B 501 (-3.7A)
0G6  B 501 (-3.6A)
0.31A88.62
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1BCU_H_PRLH280_0
(ALPHA-THROMBIN)		5ubm COMPLEMENT C1S
SUBCOMPONENT
(Homo
sapiens)		6 / 9ASP A 626
SER A 632
VAL A 653
TRP A 655
GLY A 656
GLY A 663
None
0.59A35.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1BCU_H_PRLH280_0
(ALPHA-THROMBIN)		6b74 COAGULATION FACTOR
XII
(Homo
sapiens)		6 / 9ASP B 189
ALA B 190
SER B 195
TRP B 215
GLY B 216
GLY B 226
BEN  B 301 (-2.7A)
BEN  B 301 (-4.1A)
SO4  B 304 ( 2.5A)
None
BEN  B 301 (-3.3A)
BEN  B 301 (-3.1A)
0.41Aundetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QVT_A_PRLA311_0
(TRANSCRIPTIONAL
REGULATOR QACR)		1m5i APC PROTEIN
(Homo
sapiens)		4 / 8LEU A 137
GLU A 138
GLU A 136
ILE A 231
None
1.07A22.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QVT_A_PRLA311_0
(TRANSCRIPTIONAL
REGULATOR QACR)		2r4b RECEPTOR
TYROSINE-PROTEIN
KINASE ERBB-4
(Homo
sapiens)		4 / 8LEU A 933
GLU A 934
ILE A 929
TYR A 921
None
1.13A17.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QVT_A_PRLA311_0
(TRANSCRIPTIONAL
REGULATOR QACR)		3bho CLEAVAGE AND
POLYADENYLATION
SPECIFICITY FACTOR
SUBUNIT 5
(Homo
sapiens)		4 / 8LEU A  53
GLU A  55
THR A  79
ILE A 128
None
0.80A21.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QVT_A_PRLA311_0
(TRANSCRIPTIONAL
REGULATOR QACR)		3f92 UBIQUITIN-CONJUGATIN
G ENZYME E2 K
(Homo
sapiens)		4 / 8LEU A 106
GLU A  15
ILE A   9
TYR A  66
None
1.03A21.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QVT_A_PRLA311_0
(TRANSCRIPTIONAL
REGULATOR QACR)		3iuy PROBABLE
ATP-DEPENDENT RNA
HELICASE DDX53
(Homo
sapiens)		4 / 8LEU A 266
THR A 380
ILE A 291
TYR A 239
None
1.04A18.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QVT_A_PRLA311_0
(TRANSCRIPTIONAL
REGULATOR QACR)		3zk6 BCL-2-LIKE PROTEIN 1
(Homo
sapiens)		4 / 8LEU A 178
GLU A 179
THR A 190
ILE A 140
None
1.03A22.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QVT_A_PRLA311_0
(TRANSCRIPTIONAL
REGULATOR QACR)		4a14 KINESIN-LIKE PROTEIN
KIF7
(Homo
sapiens)		4 / 8LEU A 286
GLU A  10
ILE A 296
TYR A 298
None
1.08A17.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QVT_A_PRLA311_0
(TRANSCRIPTIONAL
REGULATOR QACR)		4b9d SERINE/THREONINE-PRO
TEIN KINASE NEK1
(Homo
sapiens)		4 / 8GLU A  68
THR A  24
TYR A   4
ILE A  32
None
1.00A20.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QVT_A_PRLA311_0
(TRANSCRIPTIONAL
REGULATOR QACR)		4gv1 RAC-ALPHA
SERINE/THREONINE-PRO
TEIN KINASE
(Homo
sapiens)		4 / 8LEU A 321
GLU A 322
GLU A 319
ILE A 361
None
1.12A18.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QVT_A_PRLA311_0
(TRANSCRIPTIONAL
REGULATOR QACR)		4jqf CST COMPLEX SUBUNIT
STN1
(Homo
sapiens)		4 / 8LEU A 229
GLU A 230
GLU A 228
ILE A 271
None
1.10A22.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QVT_A_PRLA311_0
(TRANSCRIPTIONAL
REGULATOR QACR)		4n68 CONTACTIN-5
(Homo
sapiens)		4 / 8LEU A 940
TRP A 914
THR A 949
ILE A 892
None
1.03A22.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QVT_A_PRLA311_0
(TRANSCRIPTIONAL
REGULATOR QACR)		4rwa SOLUBLE CYTOCHROME
B562,DELTA-TYPE
OPIOID RECEPTOR
(Escherichia
coli;
Homo
sapiens)		4 / 8LEU A 200
TRP A 209
ILE A 183
TYR A 129
None
0.73A17.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QVT_A_PRLA311_0
(TRANSCRIPTIONAL
REGULATOR QACR)		4uyb SEC14-LIKE PROTEIN 3
(Homo
sapiens)		4 / 8LEU A 209
GLU A 211
ILE A 217
TYR A 202
None
1.10A16.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QVT_A_PRLA311_0
(TRANSCRIPTIONAL
REGULATOR QACR)		5d1x D4-30 HEAVY CHAIN
(Homo
sapiens)		4 / 8LEU B  67
THR B 107
TYR B  90
ILE B  48
None
1.08A22.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QVT_A_PRLA311_0
(TRANSCRIPTIONAL
REGULATOR QACR)		5e52 CONTACTIN-5
(Homo
sapiens)		4 / 8LEU A 940
TRP A 914
THR A 949
ILE A 892
None
0.96A19.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QVT_A_PRLA311_0
(TRANSCRIPTIONAL
REGULATOR QACR)		5j9z EPIDERMAL GROWTH
FACTOR RECEPTOR
(Homo
sapiens)		4 / 8LEU A 927
GLU A 928
ILE A 923
TYR A 915
None
1.00A19.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QVT_A_PRLA311_0
(TRANSCRIPTIONAL
REGULATOR QACR)		5thh TYROSINE--TRNA
LIGASE, CYTOPLASMIC
(Homo
sapiens)		4 / 8LEU A 177
TRP A  40
ILE A 118
TYR A 123
None
1.05A20.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QVT_A_PRLA311_0
(TRANSCRIPTIONAL
REGULATOR QACR)		5zal ENDORIBONUCLEASE
DICER
(Homo
sapiens)		4 / 8LEU A 219
GLU A 220
ILE A 582
TYR A 543
None
1.15Aundetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QVT_A_PRLA311_0
(TRANSCRIPTIONAL
REGULATOR QACR)		6f39 COMPLEMENT C1R
SUBCOMPONENT
(Homo
sapiens)		4 / 8GLU A 179
THR A 182
TYR A 181
ILE A 188
None
0.90Aundetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QVU_A_PRLA196_0
(TRANSCRIPTIONAL
REGULATOR QACR)		1elw TPR1-DOMAIN OF HOP
(Homo
sapiens)		4 / 6LEU A  99
GLU A 102
TRP A  71
THR A  64
None
1.43A22.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QVU_A_PRLA196_0
(TRANSCRIPTIONAL
REGULATOR QACR)		2a1a INTERFERON-INDUCED,
DOUBLE-STRANDED
RNA-ACTIVATED
PROTEIN KINASE
(Homo
sapiens)		4 / 6LEU B 374
GLU B 375
THR B 451
TYR B 454
None
1.43A22.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QVU_A_PRLA196_0
(TRANSCRIPTIONAL
REGULATOR QACR)		2a30 DEOXYCYTIDINE KINASE
(Homo
sapiens)		4 / 6LEU A 170
GLU A 171
THR A 223
TYR A 131
None
1.48A20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QVU_A_PRLA196_0
(TRANSCRIPTIONAL
REGULATOR QACR)		2qyf MAD2L1-BINDING
PROTEIN
(Homo
sapiens)		4 / 6LEU B 135
GLU B 139
THR B 183
TYR B  91
None
1.27A18.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QVU_A_PRLA196_0
(TRANSCRIPTIONAL
REGULATOR QACR)		3iuy PROBABLE
ATP-DEPENDENT RNA
HELICASE DDX53
(Homo
sapiens)		4 / 6LEU A 266
THR A 380
TYR A 381
TYR A 239
None
1.15A18.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QVU_A_PRLA196_0
(TRANSCRIPTIONAL
REGULATOR QACR)		4i5j SERINE/THREONINE-PRO
TEIN PHOSPHATASE 2A
REGULATORY SUBUNIT
B'' SUBUNIT ALPHA
(Homo
sapiens)		4 / 6TRP A 342
THR A 354
TYR A 358
TYR A 305
None
1.45A21.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QVU_A_PRLA196_0
(TRANSCRIPTIONAL
REGULATOR QACR)		5fjv NEURONAL
ACETYLCHOLINE
RECEPTOR SUBUNIT
ALPHA-2
(Homo
sapiens)		4 / 6LEU A  85
THR A 213
TYR A 231
TYR A 153
None
1.40A24.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QVU_A_PRLA196_0
(TRANSCRIPTIONAL
REGULATOR QACR)		5tc4 BIFUNCTIONAL
METHYLENETETRAHYDROF
OLATE
DEHYDROGENASE/CYCLOH
YDROLASE,
MITOCHONDRIAL
(Homo
sapiens)		4 / 6LEU A  45
GLU A 182
TRP A 181
THR A 191
None
1.41A18.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V57_A_PRLA1188_0
(TETR FAMILY
TRANSCRIPTIONAL
REPRESSOR LFRR)		3hf1 RIBONUCLEOSIDE-DIPHO
SPHATE REDUCTASE
SUBUNIT M2 B
(Homo
sapiens)		4 / 8SER A 220
ASN A 221
ILE A 224
TYR A 145
None
1.08A20.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V57_A_PRLA1188_0
(TETR FAMILY
TRANSCRIPTIONAL
REPRESSOR LFRR)		4e1o HISTIDINE
DECARBOXYLASE
(Homo
sapiens)		4 / 8HIS A 380
ILE A 460
ASP A 459
ARG A  26
None
1.10A18.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V57_A_PRLA1188_0
(TETR FAMILY
TRANSCRIPTIONAL
REPRESSOR LFRR)		5c2k TRANSFORMING PROTEIN
RHOA,RAC
GTPASE-ACTIVATING
PROTEIN 1
(Homo
sapiens)		4 / 8SER A 218
ILE A 224
ASP A 333
ARG A 332
None
1.12A19.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V57_A_PRLA1188_0
(TETR FAMILY
TRANSCRIPTIONAL
REPRESSOR LFRR)		5fqd DNA DAMAGE-BINDING
PROTEIN 1
(Homo
sapiens)		4 / 8SER A1096
ILE A1094
ASP A1090
ARG A1074
None
1.05A14.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V57_A_PRLA1188_0
(TETR FAMILY
TRANSCRIPTIONAL
REPRESSOR LFRR)		5k47 POLYCYSTIN-2
(Homo
sapiens)		4 / 8SER A 530
ASN A 525
ILE A 526
TYR A 465
None
0.87A16.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V57_C_PRLC1187_0
(TETR FAMILY
TRANSCRIPTIONAL
REPRESSOR LFRR)		3hf1 RIBONUCLEOSIDE-DIPHO
SPHATE REDUCTASE
SUBUNIT M2 B
(Homo
sapiens)		4 / 8SER A 220
ASN A 221
ILE A 224
TYR A 145
None
1.08A20.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V57_C_PRLC1187_0
(TETR FAMILY
TRANSCRIPTIONAL
REPRESSOR LFRR)		4e1o HISTIDINE
DECARBOXYLASE
(Homo
sapiens)		4 / 8HIS A 380
ILE A 460
ASP A 459
ARG A  26
None
1.10A18.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V57_C_PRLC1187_0
(TETR FAMILY
TRANSCRIPTIONAL
REPRESSOR LFRR)		5c2k TRANSFORMING PROTEIN
RHOA,RAC
GTPASE-ACTIVATING
PROTEIN 1
(Homo
sapiens)		4 / 8SER A 218
ILE A 224
ASP A 333
ARG A 332
None
1.11A19.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V57_C_PRLC1187_0
(TETR FAMILY
TRANSCRIPTIONAL
REPRESSOR LFRR)		5fqd DNA DAMAGE-BINDING
PROTEIN 1
(Homo
sapiens)		4 / 8SER A1096
ILE A1094
ASP A1090
ARG A1074
None
1.05A14.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V57_C_PRLC1187_0
(TETR FAMILY
TRANSCRIPTIONAL
REPRESSOR LFRR)		5k47 POLYCYSTIN-2
(Homo
sapiens)		4 / 8SER A 530
ASN A 525
ILE A 526
TYR A 465
None
0.86A16.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HTH_B_PRLB201_0
(EBRA REPRESSOR)		1gh6 RETINOBLASTOMA-ASSOC
IATED PROTEIN
(Homo
sapiens)		5 / 9LEU B 561
GLU B 737
TYR B 749
LEU B 564
ASP B 697
None
1.21A20.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZPH_A_PRLA501_0
(ARYL HYDROCARBON
RECEPTOR NUCLEAR
TRANSLOCATOR
ENDOTHELIAL PAS
DOMAIN-CONTAINING
PROTEIN 1)		2cbz MULTIDRUG
RESISTANCE-ASSOCIATE
D PROTEIN 1
(Homo
sapiens)		4 / 7VAL A 776
LEU A 722
SER A 721
GLU A 724
None
0.93A20.97
19.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZPH_A_PRLA501_0
(ARYL HYDROCARBON
RECEPTOR NUCLEAR
TRANSLOCATOR
ENDOTHELIAL PAS
DOMAIN-CONTAINING
PROTEIN 1)		2if7 SLAM FAMILY MEMBER 6
(Homo
sapiens)		4 / 7VAL A 159
TRP A 144
LEU A 151
SER A 152
None
0.81A21.07
18.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZPH_A_PRLA501_0
(ARYL HYDROCARBON
RECEPTOR NUCLEAR
TRANSLOCATOR
ENDOTHELIAL PAS
DOMAIN-CONTAINING
PROTEIN 1)		3lra DISKS LARGE HOMOLOG
1, MAGUK P55
SUBFAMILY MEMBER 7,
PROTEIN LIN-7
HOMOLOG C
(Homo
sapiens)		4 / 7VAL A   3
GLN A  53
LEU A 115
SER A 114
None
1.09A20.15
19.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZPH_A_PRLA501_0
(ARYL HYDROCARBON
RECEPTOR NUCLEAR
TRANSLOCATOR
ENDOTHELIAL PAS
DOMAIN-CONTAINING
PROTEIN 1)		4asi ACETYL-COA
CARBOXYLASE 1
(Homo
sapiens)		4 / 7VAL A2030
GLN A2006
LEU A2032
SER A2033
None
1.10A19.20
19.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZPH_A_PRLA501_0
(ARYL HYDROCARBON
RECEPTOR NUCLEAR
TRANSLOCATOR
ENDOTHELIAL PAS
DOMAIN-CONTAINING
PROTEIN 1)		4c3z MULTIDRUG
RESISTANCE-ASSOCIATE
D PROTEIN 1
(Homo
sapiens)		4 / 7VAL A 776
LEU A 722
SER A 721
GLU A 724
None
0.96A22.39
20.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZPH_A_PRLA501_0
(ARYL HYDROCARBON
RECEPTOR NUCLEAR
TRANSLOCATOR
ENDOTHELIAL PAS
DOMAIN-CONTAINING
PROTEIN 1)		4i1q BRIDGING INTEGRATOR
2
(Homo
sapiens)		4 / 7VAL A 103
GLN A  86
LEU A  99
GLU A  97
None
0.73A18.25
20.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZPH_A_PRLA501_0
(ARYL HYDROCARBON
RECEPTOR NUCLEAR
TRANSLOCATOR
ENDOTHELIAL PAS
DOMAIN-CONTAINING
PROTEIN 1)		4kkd MANNAN-BINDING
LECTIN SERINE
PROTEASE 1
(Homo
sapiens)		4 / 7VAL A 711
TRP A 491
LEU A 487
SER A 488
None
1.10A23.03
21.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZPH_A_PRLA501_0
(ARYL HYDROCARBON
RECEPTOR NUCLEAR
TRANSLOCATOR
ENDOTHELIAL PAS
DOMAIN-CONTAINING
PROTEIN 1)		4rh7 GREEN FLUORESCENT
PROTEIN/CYTOPLASMIC
DYNEIN 2 HEAVY CHAIN
1
(Homo
sapiens;
synthetic
construct)		4 / 7VAL A4100
LEU A4107
SER A4108
GLU A4110
None
0.99A7.30
7.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZPH_A_PRLA501_0
(ARYL HYDROCARBON
RECEPTOR NUCLEAR
TRANSLOCATOR
ENDOTHELIAL PAS
DOMAIN-CONTAINING
PROTEIN 1)		4rxx UBIQUITIN
CARBOXYL-TERMINAL
HYDROLASE 38
(Homo
sapiens)		4 / 7ARG A 320
VAL A 317
LEU A 278
SER A 279
None
1.06A22.05
21.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZPH_A_PRLA501_0
(ARYL HYDROCARBON
RECEPTOR NUCLEAR
TRANSLOCATOR
ENDOTHELIAL PAS
DOMAIN-CONTAINING
PROTEIN 1)		4u1r ATP-DEPENDENT
6-PHOSPHOFRUCTOKINAS
E, PLATELET TYPE
(Homo
sapiens)		4 / 7ARG A  48
VAL A  47
SER A  83
GLU A  80
PO4  A 804 (-3.2A)
None
PO4  A 804 (-4.3A)
None
0.93A19.50
18.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZPH_A_PRLA501_0
(ARYL HYDROCARBON
RECEPTOR NUCLEAR
TRANSLOCATOR
ENDOTHELIAL PAS
DOMAIN-CONTAINING
PROTEIN 1)		4wik SPLICING FACTOR,
PROLINE- AND
GLUTAMINE-RICH
(Homo
sapiens)		4 / 7ARG A 443
VAL A 445
LEU A 378
SER A 379
None
1.09A20.16
20.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZPH_A_PRLA501_0
(ARYL HYDROCARBON
RECEPTOR NUCLEAR
TRANSLOCATOR
ENDOTHELIAL PAS
DOMAIN-CONTAINING
PROTEIN 1)		5f4y PROTEIN SHROOM2
(Homo
sapiens)		4 / 7VAL A1461
GLN A1588
LEU A1457
GLU A1455
None
1.06A19.25
20.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZPH_A_PRLA501_0
(ARYL HYDROCARBON
RECEPTOR NUCLEAR
TRANSLOCATOR
ENDOTHELIAL PAS
DOMAIN-CONTAINING
PROTEIN 1)		5ifn PARASPECKLE
COMPONENT 1
(Homo
sapiens)		4 / 7ARG A 228
VAL A 230
LEU A 163
SER A 164
None
0.96A18.94
23.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZPH_A_PRLA501_0
(ARYL HYDROCARBON
RECEPTOR NUCLEAR
TRANSLOCATOR
ENDOTHELIAL PAS
DOMAIN-CONTAINING
PROTEIN 1)		5mpg HETEROGENEOUS
NUCLEAR
RIBONUCLEOPROTEIN A1
(Homo
sapiens)		4 / 7ARG A  82
VAL A  84
LEU A  21
SER A  22
 U  B   1 ( 3.0A)
None
None
None
0.94A15.49
16.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZPH_A_PRLA501_0
(ARYL HYDROCARBON
RECEPTOR NUCLEAR
TRANSLOCATOR
ENDOTHELIAL PAS
DOMAIN-CONTAINING
PROTEIN 1)		6cet GATOR COMPLEX
PROTEIN NPRL3
GATOR COMPLEX
PROTEIN NPRL2
(Homo
sapiens;
Homo
sapiens)		4 / 7VAL N 281
GLN M 405
LEU N 278
GLU N 367
None
1.04Aundetectable