POTENTIAL TARGETS FROM HUMAN (RESULTS FROM SUB-STRUCTURAL SIMILARITY SEARCHES)1) User may click on the DrReposER ID (the second column) to get information on the binding sites and drug molecule.
2) Click View (the second last column) to view matched residues and superposition in the NGL viewer (upper right part).
3) User may also click on the Dock (the last column) to get script for molecular docking in UCSF Chimera through AutoDock Vina.

	DrReposER ID / Desc.	Hit PDBID	Hit Macromolecule	Res. Matches	Interface	HETATM	RMSD	Seq. Identity (%)	View	Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1SA1_B_PODB700_1 (TUBULIN ALPHA CHAIN TUBULIN BETA CHAIN)	1awb	MYO-INOSITOL MONOPHOSPHATASE (Homo sapiens)	5 / 12	VAL A 193 LEU A 235 ALA A 252 ASN A 199 VAL A 148	None	1.09A	21.51 18.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1SA1_B_PODB700_1 (TUBULIN ALPHA CHAIN TUBULIN BETA CHAIN)	1xqs	HSPBP1 PROTEIN (Homo sapiens)	5 / 12	VAL A 248 LEU A 195 ALA A 208 ALA A 238 VAL A 234	None	1.10A	20.54 21.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1SA1_B_PODB700_1 (TUBULIN ALPHA CHAIN TUBULIN BETA CHAIN)	2irw	CORTICOSTEROID 11-BETA-DEHYDROGENAS E ISOZYME 1 (Homo sapiens)	5 / 12	CYH A  78 LEU A  79 ALA A  83 MET A 110 ALA A  51	None	1.04A	19.18 18.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1SA1_B_PODB700_1 (TUBULIN ALPHA CHAIN TUBULIN BETA CHAIN)	3zyx	AMINE OXIDASE [FLAVIN-CONTAINING] B (Homo sapiens)	5 / 12	LEU A  22 ALA A 447 LEU A 451 MET A 454 VAL A  30	None	0.98A	20.70 20.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1SA1_B_PODB700_1 (TUBULIN ALPHA CHAIN TUBULIN BETA CHAIN)	4chb	KELCH-LIKE PROTEIN 2 (Homo sapiens)	5 / 12	VAL A 444 ALA A 419 LEU A 401 ALA A 471 ALA A 431	None	1.18A	21.49 24.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1SA1_B_PODB700_1 (TUBULIN ALPHA CHAIN TUBULIN BETA CHAIN)	4piv	FATTY ACID SYNTHASE (Homo sapiens)	5 / 12	LEU A1336 ALA A1310 LYS A1241 LEU A1312 VAL A1245	None	1.14A	21.02 20.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1SA1_B_PODB700_1 (TUBULIN ALPHA CHAIN TUBULIN BETA CHAIN)	5a2e	T-CELL DIFFERENTIATION ANTIGEN CD6 (Homo sapiens)	5 / 12	ALA A  78 LEU A 127 ALA A 151 VAL A 153 ALA A  94	None	0.94A	19.14 20.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1SA1_B_PODB700_1 (TUBULIN ALPHA CHAIN TUBULIN BETA CHAIN)	5jpn	COMPLEMENT C4-A (Homo sapiens)	5 / 12	ALA B1213 LEU B1200 ALA B1143 VAL B1139 ALA B1192	None	1.06A	20.00 20.18
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	1SA1_B_PODB700_1 (TUBULIN ALPHA CHAIN TUBULIN BETA CHAIN)	5n5n	TUBULIN BETA CHAIN (Homo sapiens)	5 / 12	ALA B 250 LEU B 255 ASN B 258 MET B 259 ALA B 316	None	1.11A	40.88 97.89
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	1SA1_B_PODB700_1 (TUBULIN ALPHA CHAIN TUBULIN BETA CHAIN)	5n5n	TUBULIN BETA CHAIN (Homo sapiens)	5 / 12	CYH B 241 LEU B 242 LEU B 252 VAL B 318 ALA B 354	None	1.02A	40.88 97.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1SA1_B_PODB700_1 (TUBULIN ALPHA CHAIN TUBULIN BETA CHAIN)	5wp6	TRANSIENT RECEPTOR POTENTIAL CATION CHANNEL SUBFAMILY M MEMBER 4 (Homo sapiens)	5 / 12	LEU A 138 ALA A 169 ASN A 228 ALA A 185 ALA A 146	None	1.12A	11.65 11.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1SA1_B_PODB700_1 (TUBULIN ALPHA CHAIN TUBULIN BETA CHAIN)	5xzx	IMPORTIN SUBUNIT ALPHA-3 (Homo sapiens)	5 / 12	CYH A 122 LEU A 123 ALA A 135 LEU A 139 ALA A  80	None	1.03A	23.66 21.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1SA1_D_PODD701_1 (TUBULIN ALPHA CHAIN TUBULIN BETA CHAIN)	1awb	MYO-INOSITOL MONOPHOSPHATASE (Homo sapiens)	5 / 12	VAL A 193 LEU A 235 ALA A 252 ASN A 199 VAL A 148	None	1.07A	21.51 18.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1SA1_D_PODD701_1 (TUBULIN ALPHA CHAIN TUBULIN BETA CHAIN)	1xqs	HSPBP1 PROTEIN (Homo sapiens)	5 / 12	VAL A 248 LEU A 195 ALA A 208 ALA A 238 VAL A 234	None	1.08A	20.54 21.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1SA1_D_PODD701_1 (TUBULIN ALPHA CHAIN TUBULIN BETA CHAIN)	2irw	CORTICOSTEROID 11-BETA-DEHYDROGENAS E ISOZYME 1 (Homo sapiens)	5 / 12	CYH A  78 LEU A  79 ALA A  83 MET A 110 ALA A  51	None	0.99A	19.18 18.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1SA1_D_PODD701_1 (TUBULIN ALPHA CHAIN TUBULIN BETA CHAIN)	2vfa	HYPOXANTHINE-GUANINE -XANTHINE PHOSPHORIBOSYLTRANSF ERASE, HYPOXANTHINE-GUANINE PHOSPHORIBOSYLTRANSF ERASE (Homo sapiens; Plasmodium falciparum)	5 / 12	ALA A  58 MET A 103 ALA A  72 VAL A 141 ALA A 169	None	1.20A	19.08 17.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1SA1_D_PODD701_1 (TUBULIN ALPHA CHAIN TUBULIN BETA CHAIN)	3zyx	AMINE OXIDASE [FLAVIN-CONTAINING] B (Homo sapiens)	5 / 12	LEU A  22 ALA A 447 LEU A 451 MET A 454 VAL A  30	None	1.00A	20.70 20.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1SA1_D_PODD701_1 (TUBULIN ALPHA CHAIN TUBULIN BETA CHAIN)	4a11	DNA EXCISION REPAIR PROTEIN ERCC-8 (Homo sapiens)	5 / 12	LEU B 261 ASN B 289 VAL B 211 LYS B 247 ALA B 205	None	1.20A	21.88 23.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1SA1_D_PODD701_1 (TUBULIN ALPHA CHAIN TUBULIN BETA CHAIN)	5a2e	T-CELL DIFFERENTIATION ANTIGEN CD6 (Homo sapiens)	5 / 12	ALA A  78 LEU A 127 ALA A 151 VAL A 153 ALA A  94	None	0.96A	19.14 20.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1SA1_D_PODD701_1 (TUBULIN ALPHA CHAIN TUBULIN BETA CHAIN)	5jpn	COMPLEMENT C4-A (Homo sapiens)	5 / 12	ALA B1213 LEU B1200 ALA B1143 VAL B1139 ALA B1192	None	1.06A	20.00 20.18
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	1SA1_D_PODD701_1 (TUBULIN ALPHA CHAIN TUBULIN BETA CHAIN)	5n5n	TUBULIN BETA CHAIN (Homo sapiens)	5 / 12	ALA B 250 LEU B 255 ASN B 258 MET B 259 ALA B 316	None	1.12A	40.88 97.89
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	1SA1_D_PODD701_1 (TUBULIN ALPHA CHAIN TUBULIN BETA CHAIN)	5n5n	TUBULIN BETA CHAIN (Homo sapiens)	5 / 12	CYH B 241 LEU B 242 LEU B 252 VAL B 318 ALA B 354	None	1.01A	40.88 97.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1SA1_D_PODD701_1 (TUBULIN ALPHA CHAIN TUBULIN BETA CHAIN)	5vni	PROTEIN TRANSPORT PROTEIN SEC24A (Homo sapiens)	5 / 12	VAL B 892 LEU B 400 ALA B 403 LEU B 405 ALA B 838	None	1.19A	20.53 20.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1SA1_D_PODD701_1 (TUBULIN ALPHA CHAIN TUBULIN BETA CHAIN)	5wp6	TRANSIENT RECEPTOR POTENTIAL CATION CHANNEL SUBFAMILY M MEMBER 4 (Homo sapiens)	5 / 12	LEU A 138 ALA A 169 ASN A 228 ALA A 185 ALA A 146	None	1.15A	11.65 11.26