POTENTIAL TARGETS FROM HUMAN (RESULTS FROM SUB-STRUCTURAL SIMILARITY SEARCHES)
1) User may click on the DrReposER ID (the second column) to get information on the binding sites and drug molecule.
2) Click View (the second last column) to view matched residues and superposition in the NGL viewer (upper right part).
3) User may also click on the Dock (the last column) to get script for molecular docking in UCSF Chimera through AutoDock Vina.

DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Seq.
Identity (%)		 View Dock
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2A3C_A_PNXA1434_1
(CHITINASE)		1hjv CHITINASE-3 LIKE
PROTEIN 1
(Homo
sapiens)		8 / 12TYR A  27
TRP A  31
PHE A  58
GLY A  98
MET A 204
TYR A 206
ASP A 207
TRP A 352
NAG  A  -1 (-3.8A)
NAG  A  -2 (-4.2A)
NAG  A  -2 (-4.7A)
NAG  A  -2 ( 4.2A)
NAG  A   1 (-3.7A)
NAG  A  -1 (-4.6A)
NAG  A  -1 (-3.7A)
NAG  A  -1 (-3.5A)
0.76A30.31
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2A3C_A_PNXA1434_1
(CHITINASE)		1hkk CHITOTRIOSIDASE-1
(Homo
sapiens)		7 / 12TRP A  31
PHE A  58
ASP A 138
GLU A 140
MET A 210
TYR A 212
TRP A 358
NAA  A1386 (-4.0A)
AMI  A1388 (-4.8A)
AMI  A1388 (-3.1A)
AMI  A1388 ( 3.3A)
AMI  A1388 (-3.3A)
AMI  A1388 (-4.8A)
AMI  A1388 (-3.5A)
1.17A30.85
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2A3C_A_PNXA1434_1
(CHITINASE)		1hkk CHITOTRIOSIDASE-1
(Homo
sapiens)		8 / 12TYR A  27
TRP A  31
PHE A  58
GLY A  98
GLU A 140
MET A 210
TYR A 212
TRP A 358
AMI  A1388 (-3.6A)
NAA  A1386 (-4.0A)
AMI  A1388 (-4.8A)
AMI  A1388 ( 3.7A)
AMI  A1388 ( 3.3A)
AMI  A1388 (-3.3A)
AMI  A1388 (-4.8A)
AMI  A1388 (-3.5A)
0.98A30.85
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2A3C_A_PNXA1434_1
(CHITINASE)		1hkk CHITOTRIOSIDASE-1
(Homo
sapiens)		9 / 12TYR A  27
TRP A  31
PHE A  58
GLY A  98
MET A 210
TYR A 212
ASP A 213
TYR A 267
TRP A 358
AMI  A1388 (-3.6A)
NAA  A1386 (-4.0A)
AMI  A1388 (-4.8A)
AMI  A1388 ( 3.7A)
AMI  A1388 (-3.3A)
AMI  A1388 (-4.8A)
AMI  A1388 ( 2.9A)
NAA  A1387 (-3.6A)
AMI  A1388 (-3.5A)
0.73A30.85
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2A3C_A_PNXA1434_1
(CHITINASE)		1wb0 CHITOTRIOSIDASE 1
(Homo
sapiens)		8 / 12TRP A  31
PHE A  58
GLY A  98
ASP A 138
GLU A 140
MET A 210
TYR A 212
TRP A 360
None
1.06A30.36
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2A3C_A_PNXA1434_1
(CHITINASE)		1wb0 CHITOTRIOSIDASE 1
(Homo
sapiens)		8 / 12TRP A  31
PHE A  58
GLY A  98
ASP A 138
MET A 210
TYR A 212
TYR A 267
TRP A 360
None
0.87A30.36
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2A3C_A_PNXA1434_1
(CHITINASE)		1wb0 CHITOTRIOSIDASE 1
(Homo
sapiens)		8 / 12TYR A  27
TRP A  31
PHE A  58
GLY A  98
GLU A 140
MET A 210
TYR A 212
TRP A 360
None
0.92A30.36
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2A3C_A_PNXA1434_1
(CHITINASE)		1wb0 CHITOTRIOSIDASE 1
(Homo
sapiens)		9 / 12TYR A  27
TRP A  31
PHE A  58
GLY A  98
MET A 210
TYR A 212
ASP A 213
TYR A 267
TRP A 360
None
0.60A30.36
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2A3C_A_PNXA1434_1
(CHITINASE)		2ybu ACIDIC MAMMALIAN
CHITINASE
(Homo
sapiens)		8 / 12TRP A  31
PHE A  58
GLY A  98
ASP A 138
GLU A 140
MET A 210
TYR A 212
TRP A 360
CX9  A1398 ( 3.4A)
CX9  A1398 (-4.5A)
CX9  A1398 (-3.5A)
CX9  A1398 (-3.0A)
CX9  A1398 (-3.7A)
CX9  A1398 (-3.3A)
CX9  A1398 (-4.3A)
CX9  A1398 ( 3.3A)
1.07A31.82
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2A3C_A_PNXA1434_1
(CHITINASE)		2ybu ACIDIC MAMMALIAN
CHITINASE
(Homo
sapiens)		8 / 12TRP A  31
PHE A  58
GLY A  98
ASP A 138
MET A 210
TYR A 212
TYR A 267
TRP A 360
CX9  A1398 ( 3.4A)
CX9  A1398 (-4.5A)
CX9  A1398 (-3.5A)
CX9  A1398 (-3.0A)
CX9  A1398 (-3.3A)
CX9  A1398 (-4.3A)
None
CX9  A1398 ( 3.3A)
0.86A31.82
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2A3C_A_PNXA1434_1
(CHITINASE)		2ybu ACIDIC MAMMALIAN
CHITINASE
(Homo
sapiens)		8 / 12TYR A  27
TRP A  31
PHE A  58
GLY A  98
GLU A 140
MET A 210
TYR A 212
TRP A 360
None
CX9  A1398 ( 3.4A)
CX9  A1398 (-4.5A)
CX9  A1398 (-3.5A)
CX9  A1398 (-3.7A)
CX9  A1398 (-3.3A)
CX9  A1398 (-4.3A)
CX9  A1398 ( 3.3A)
0.91A31.82
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2A3C_A_PNXA1434_1
(CHITINASE)		2ybu ACIDIC MAMMALIAN
CHITINASE
(Homo
sapiens)		9 / 12TYR A  27
TRP A  31
PHE A  58
GLY A  98
MET A 210
TYR A 212
ASP A 213
TYR A 267
TRP A 360
None
CX9  A1398 ( 3.4A)
CX9  A1398 (-4.5A)
CX9  A1398 (-3.5A)
CX9  A1398 (-3.3A)
CX9  A1398 (-4.3A)
CX9  A1398 ( 4.4A)
None
CX9  A1398 ( 3.3A)
0.59A31.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2A3C_A_PNXA1434_1
(CHITINASE)		4ay1 CHITINASE-3-LIKE
PROTEIN 2
(Homo
sapiens)		7 / 12TYR A  32
TRP A  36
PHE A  63
GLY A 103
ASP A 213
TYR A 269
TRP A 360
NAG  A 401 (-3.9A)
NAG  A 400 (-4.3A)
None
NAG  A 401 (-3.5A)
NAG  A 401 (-2.8A)
NAG  A 400 (-3.7A)
NAG  A 401 (-3.7A)
0.76A28.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2A3C_A_PNXA1435_1
(CHITINASE)		1q20 SULFOTRANSFERASE
FAMILY, CYTOSOLIC,
2B, MEMBER 1 ISOFORM
B
(Homo
sapiens)		4 / 6TYR A  34
GLY A 109
PHE A 111
SER A 112
None
1.28A21.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2A3C_A_PNXA1435_1
(CHITINASE)		1z8l GLUTAMATE
CARBOXYPEPTIDASE II
(Homo
sapiens)		4 / 6TYR A 299
GLY A 548
PHE A 546
SER A 547
None
1.23A21.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2A3C_A_PNXA1435_1
(CHITINASE)		1zd1 SULFOTRANSFERASE 4A1
(Homo
sapiens)		4 / 6TYR A 172
GLY A  57
PHE A 145
SER A 141
None
1.39A20.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2A3C_A_PNXA1435_1
(CHITINASE)		3iec SERINE/THREONINE-PRO
TEIN KINASE MARK2
(Homo
sapiens)		4 / 6TYR A 215
GLY A 195
PHE A 196
SER A 197
None
1.25A21.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2A3C_A_PNXA1435_1
(CHITINASE)		3ll8 SERINE/THREONINE-PRO
TEIN PHOSPHATASE 2B
CATALYTIC SUBUNIT
ALPHA ISOFORM
(Homo
sapiens)		4 / 6TYR A 291
GLY A  89
PHE A 306
SER A 307
None
1.28A21.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2A3C_A_PNXA1435_1
(CHITINASE)		3op0 SIGNAL TRANSDUCTION
PROTEIN CBL-C
(Homo
sapiens)		4 / 6TYR A 244
GLY A 282
SER A 279
ARG A 255
None
1.39A22.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2A3C_A_PNXA1435_1
(CHITINASE)		3q5e ATLASTIN-1
(Homo
sapiens)		4 / 6TYR A 328
GLY A 410
PHE A 413
SER A 414
None
1.10A23.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2A3C_A_PNXA1435_1
(CHITINASE)		4lr2 BIS(5'-ADENOSYL)-TRI
PHOSPHATASE ENPP4
(Homo
sapiens)		4 / 6TYR A 154
GLY A  35
PHE A  33
SER A 236
None
ZN  A 505 ( 4.8A)
None
None
1.31A20.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2A3C_A_PNXA1435_1
(CHITINASE)		4ora SERINE/THREONINE-PRO
TEIN PHOSPHATASE 2B
CATALYTIC SUBUNIT
BETA ISOFORM
(Homo
sapiens)		4 / 6TYR A 300
GLY A  98
PHE A 315
SER A 316
None
1.31A20.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2A3C_A_PNXA1435_1
(CHITINASE)		4raf PROTEIN PHOSPHATASE
1A
(Homo
sapiens)		4 / 6TRP A  53
TYR A 140
GLY A  90
SER A  88
None
1.30A21.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2A3C_A_PNXA1435_1
(CHITINASE)		4xw3 ATP-DEPENDENT RNA
HELICASE DDX1
(Homo
sapiens)		4 / 6TYR A 135
GLY A 159
PHE A 165
SER A 174
None
0.76A18.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2A3C_A_PNXA1435_1
(CHITINASE)		5mj3 INTERLEUKIN-12
SUBUNIT BETA
(Homo
sapiens)		4 / 6TYR A 315
PHE A 227
SER A 226
ARG A 160
None
1.38A20.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2A3C_A_PNXA1435_1
(CHITINASE)		5uqe GLUTAMINASE KIDNEY
ISOFORM,
MITOCHONDRIAL
(Homo
sapiens)		4 / 6TYR A 530
GLY A 464
PHE A 472
SER A 469
None
0.98A22.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2A3C_A_PNXA1435_1
(CHITINASE)		5vem ECTONUCLEOTIDE
PYROPHOSPHATASE/PHOS
PHODIESTERASE FAMILY
MEMBER 5
(Homo
sapiens)		4 / 6TYR A 157
GLY A  37
PHE A  35
SER A 237
None
ZN  A 501 ( 4.9A)
None
None
1.21A20.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2A3C_A_PNXA1435_1
(CHITINASE)		5xra CANNABINOID RECEPTOR
1,FLAVODOXIN,CANNABI
NOID RECEPTOR 1
(Desulfovibrio
vulgaris;
Homo
sapiens)		4 / 6TRP A 356
GLY A 166
PHE A 170
SER A 167
None
None
8D3  A 602 ( 4.4A)
None
1.24A21.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2A3C_A_PNXA1435_1
(CHITINASE)		6bf6 INSULIN-DEGRADING
ENZYME
(Homo
sapiens)		4 / 6TRP A 199
TYR A 496
GLY A 144
SER A  96
None
1.29A11.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2A3C_A_PNXA1435_1
(CHITINASE)		6bq1 PROTEIN FAM126A
(Homo
sapiens)		4 / 6TYR C 109
GLY C 235
PHE C 236
SER C 233
None
1.06A12.53
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2A3C_B_PNXB2433_1
(CHITINASE)		1hjv CHITINASE-3 LIKE
PROTEIN 1
(Homo
sapiens)		7 / 12TRP A  31
PHE A  58
GLY A  98
MET A 204
TYR A 206
ASP A 207
TRP A 352
NAG  A  -2 (-4.2A)
NAG  A  -2 (-4.7A)
NAG  A  -2 ( 4.2A)
NAG  A   1 (-3.7A)
NAG  A  -1 (-4.6A)
NAG  A  -1 (-3.7A)
NAG  A  -1 (-3.5A)
0.61A30.31
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2A3C_B_PNXB2433_1
(CHITINASE)		1hkk CHITOTRIOSIDASE-1
(Homo
sapiens)		7 / 12TRP A  31
PHE A  58
ASP A 138
GLU A 140
MET A 210
TYR A 212
TRP A 358
NAA  A1386 (-4.0A)
AMI  A1388 (-4.8A)
AMI  A1388 (-3.1A)
AMI  A1388 ( 3.3A)
AMI  A1388 (-3.3A)
AMI  A1388 (-4.8A)
AMI  A1388 (-3.5A)
1.12A30.85
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2A3C_B_PNXB2433_1
(CHITINASE)		1hkk CHITOTRIOSIDASE-1
(Homo
sapiens)		7 / 12TRP A  31
PHE A  58
ASP A 138
MET A 210
TYR A 212
TYR A 267
TRP A 358
NAA  A1386 (-4.0A)
AMI  A1388 (-4.8A)
AMI  A1388 (-3.1A)
AMI  A1388 (-3.3A)
AMI  A1388 (-4.8A)
NAA  A1387 (-3.6A)
AMI  A1388 (-3.5A)
0.96A30.85
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2A3C_B_PNXB2433_1
(CHITINASE)		1hkk CHITOTRIOSIDASE-1
(Homo
sapiens)		7 / 12TRP A  31
PHE A  58
GLY A  98
GLU A 140
MET A 210
TYR A 212
TRP A 358
NAA  A1386 (-4.0A)
AMI  A1388 (-4.8A)
AMI  A1388 ( 3.7A)
AMI  A1388 ( 3.3A)
AMI  A1388 (-3.3A)
AMI  A1388 (-4.8A)
AMI  A1388 (-3.5A)
0.81A30.85
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2A3C_B_PNXB2433_1
(CHITINASE)		1hkk CHITOTRIOSIDASE-1
(Homo
sapiens)		8 / 12TRP A  31
PHE A  58
GLY A  98
MET A 210
TYR A 212
ASP A 213
TYR A 267
TRP A 358
NAA  A1386 (-4.0A)
AMI  A1388 (-4.8A)
AMI  A1388 ( 3.7A)
AMI  A1388 (-3.3A)
AMI  A1388 (-4.8A)
AMI  A1388 ( 2.9A)
NAA  A1387 (-3.6A)
AMI  A1388 (-3.5A)
0.51A30.85
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2A3C_B_PNXB2433_1
(CHITINASE)		1wb0 CHITOTRIOSIDASE 1
(Homo
sapiens)		8 / 12TRP A  31
PHE A  58
GLY A  98
ASP A 138
GLU A 140
MET A 210
TYR A 212
TRP A 360
None
1.02A30.36
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2A3C_B_PNXB2433_1
(CHITINASE)		1wb0 CHITOTRIOSIDASE 1
(Homo
sapiens)		8 / 12TRP A  31
PHE A  58
GLY A  98
ASP A 138
MET A 210
TYR A 212
TYR A 267
TRP A 360
None
0.83A30.36
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2A3C_B_PNXB2433_1
(CHITINASE)		1wb0 CHITOTRIOSIDASE 1
(Homo
sapiens)		8 / 12TRP A  31
PHE A  58
GLY A  98
MET A 210
TYR A 212
ASP A 213
TYR A 267
TRP A 360
None
0.43A30.36
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2A3C_B_PNXB2433_1
(CHITINASE)		2ybu ACIDIC MAMMALIAN
CHITINASE
(Homo
sapiens)		8 / 12TRP A  31
PHE A  58
GLY A  98
ASP A 138
GLU A 140
MET A 210
TYR A 212
TRP A 360
CX9  A1398 ( 3.4A)
CX9  A1398 (-4.5A)
CX9  A1398 (-3.5A)
CX9  A1398 (-3.0A)
CX9  A1398 (-3.7A)
CX9  A1398 (-3.3A)
CX9  A1398 (-4.3A)
CX9  A1398 ( 3.3A)
1.03A31.82
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2A3C_B_PNXB2433_1
(CHITINASE)		2ybu ACIDIC MAMMALIAN
CHITINASE
(Homo
sapiens)		8 / 12TRP A  31
PHE A  58
GLY A  98
ASP A 138
MET A 210
TYR A 212
TYR A 267
TRP A 360
CX9  A1398 ( 3.4A)
CX9  A1398 (-4.5A)
CX9  A1398 (-3.5A)
CX9  A1398 (-3.0A)
CX9  A1398 (-3.3A)
CX9  A1398 (-4.3A)
None
CX9  A1398 ( 3.3A)
0.84A31.82
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2A3C_B_PNXB2433_1
(CHITINASE)		2ybu ACIDIC MAMMALIAN
CHITINASE
(Homo
sapiens)		8 / 12TRP A  31
PHE A  58
GLY A  98
MET A 210
TYR A 212
ASP A 213
TYR A 267
TRP A 360
CX9  A1398 ( 3.4A)
CX9  A1398 (-4.5A)
CX9  A1398 (-3.5A)
CX9  A1398 (-3.3A)
CX9  A1398 (-4.3A)
CX9  A1398 ( 4.4A)
None
CX9  A1398 ( 3.3A)
0.43A31.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2A3C_B_PNXB2433_1
(CHITINASE)		4ay1 CHITINASE-3-LIKE
PROTEIN 2
(Homo
sapiens)		6 / 12TRP A  36
PHE A  63
GLY A 103
ASP A 213
TYR A 269
TRP A 360
NAG  A 400 (-4.3A)
None
NAG  A 401 (-3.5A)
NAG  A 401 (-2.8A)
NAG  A 400 (-3.7A)
NAG  A 401 (-3.7A)
0.60A28.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2A3C_B_PNXB2434_1
(CHITINASE)		1q20 SULFOTRANSFERASE
FAMILY, CYTOSOLIC,
2B, MEMBER 1 ISOFORM
B
(Homo
sapiens)		4 / 6TYR A  34
GLY A 109
PHE A 111
SER A 112
None
1.35A21.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2A3C_B_PNXB2434_1
(CHITINASE)		1w6j LANOSTEROL SYNTHASE
(Homo
sapiens)		4 / 6TRP A 230
TYR A 530
PHE A 696
SER A 699
None
None
R71  A1733 (-3.6A)
None
1.39A21.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2A3C_B_PNXB2434_1
(CHITINASE)		1z8l GLUTAMATE
CARBOXYPEPTIDASE II
(Homo
sapiens)		4 / 6TYR A 299
GLY A 548
PHE A 546
SER A 547
None
1.19A21.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2A3C_B_PNXB2434_1
(CHITINASE)		1zd1 SULFOTRANSFERASE 4A1
(Homo
sapiens)		4 / 6TYR A 172
GLY A  57
PHE A 145
SER A 141
None
1.39A20.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2A3C_B_PNXB2434_1
(CHITINASE)		3ll8 SERINE/THREONINE-PRO
TEIN PHOSPHATASE 2B
CATALYTIC SUBUNIT
ALPHA ISOFORM
(Homo
sapiens)		4 / 6TYR A 291
GLY A  89
PHE A 306
SER A 307
None
1.31A21.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2A3C_B_PNXB2434_1
(CHITINASE)		3op0 SIGNAL TRANSDUCTION
PROTEIN CBL-C
(Homo
sapiens)		4 / 6TYR A 244
GLY A 282
SER A 279
ARG A 255
None
1.40A22.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2A3C_B_PNXB2434_1
(CHITINASE)		3q5e ATLASTIN-1
(Homo
sapiens)		4 / 6TYR A 328
GLY A 410
PHE A 413
SER A 414
None
1.06A23.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2A3C_B_PNXB2434_1
(CHITINASE)		4lxl LYSINE-SPECIFIC
DEMETHYLASE 4B
(Homo
sapiens)		4 / 6TYR A 254
GLY A 230
PHE A 228
SER A 232
None
1.28A20.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2A3C_B_PNXB2434_1
(CHITINASE)		4ora SERINE/THREONINE-PRO
TEIN PHOSPHATASE 2B
CATALYTIC SUBUNIT
BETA ISOFORM
(Homo
sapiens)		4 / 6TYR A 300
GLY A  98
PHE A 315
SER A 316
None
1.33A20.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2A3C_B_PNXB2434_1
(CHITINASE)		4raf PROTEIN PHOSPHATASE
1A
(Homo
sapiens)		4 / 6TRP A  53
TYR A 140
GLY A  90
SER A  88
None
1.29A21.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2A3C_B_PNXB2434_1
(CHITINASE)		4uij BTB/POZ
DOMAIN-CONTAINING
ADAPTER FOR
CUL3-MEDIATED RHOA
DEGRADATION PROTEIN
1
(Homo
sapiens)		4 / 6TYR A 123
GLY A  72
PHE A  70
SER A  71
None
1.23A15.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2A3C_B_PNXB2434_1
(CHITINASE)		4xw3 ATP-DEPENDENT RNA
HELICASE DDX1
(Homo
sapiens)		4 / 6TYR A 135
GLY A 159
PHE A 165
SER A 174
None
0.84A18.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2A3C_B_PNXB2434_1
(CHITINASE)		4y7i MYOTUBULARIN-RELATED
PROTEIN 8
(Homo
sapiens)		4 / 6GLY A 441
PHE A 381
SER A 382
ARG A 447
None
1.37A17.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2A3C_B_PNXB2434_1
(CHITINASE)		5d3o GLUTAMINASE KIDNEY
ISOFORM,
MITOCHONDRIAL
(Homo
sapiens)		4 / 6TYR A 535
GLY A 469
PHE A 477
SER A 474
None
1.04A20.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2A3C_B_PNXB2434_1
(CHITINASE)		5neu INTEGRIN ALPHA-V
(Homo
sapiens)		4 / 6TRP A  93
GLY A  20
PHE A 427
SER A 407
None
1.40A22.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2A3C_B_PNXB2434_1
(CHITINASE)		5uqe GLUTAMINASE KIDNEY
ISOFORM,
MITOCHONDRIAL
(Homo
sapiens)		4 / 6TYR A 530
GLY A 464
PHE A 472
SER A 469
None
0.98A22.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2A3C_B_PNXB2434_1
(CHITINASE)		5vem ECTONUCLEOTIDE
PYROPHOSPHATASE/PHOS
PHODIESTERASE FAMILY
MEMBER 5
(Homo
sapiens)		4 / 6TYR A 157
GLY A  37
PHE A  35
SER A 237
None
ZN  A 501 ( 4.9A)
None
None
1.30A20.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2A3C_B_PNXB2434_1
(CHITINASE)		5xra CANNABINOID RECEPTOR
1,FLAVODOXIN,CANNABI
NOID RECEPTOR 1
(Desulfovibrio
vulgaris;
Homo
sapiens)		4 / 6TRP A 356
GLY A 166
PHE A 170
SER A 167
None
None
8D3  A 602 ( 4.4A)
None
1.32A21.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2A3C_B_PNXB2434_1
(CHITINASE)		6bq1 PROTEIN FAM126A
(Homo
sapiens)		4 / 6TYR C 109
GLY C 235
PHE C 236
SER C 233
None
1.09A12.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ARR_A_PNXA606_1
(CHITINASE A)		1hjv CHITINASE-3 LIKE
PROTEIN 1
(Homo
sapiens)		4 / 7TRP A  99
GLY A 181
ASP A 207
ARG A 263
NAG  A   1 (-3.6A)
NAG  A   2 (-3.3A)
NAG  A  -1 (-3.7A)
NAG  A  -2 (-4.2A)
0.77A24.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ARR_A_PNXA606_1
(CHITINASE A)		1hkk CHITOTRIOSIDASE-1
(Homo
sapiens)		5 / 7TRP A  99
GLY A 187
ASP A 213
TRP A 218
ARG A 269
NAA  A1390 ( 4.3A)
AMI  A1391 (-3.3A)
AMI  A1388 ( 2.9A)
NAA  A1390 (-3.2A)
NAA  A1389 (-3.2A)
0.60A25.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ARR_A_PNXA606_1
(CHITINASE A)		1w6j LANOSTEROL SYNTHASE
(Homo
sapiens)		4 / 7TRP A 141
GLY A 167
ASP A 172
ARG A 175
None
0.95A21.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ARR_A_PNXA606_1
(CHITINASE A)		1wb0 CHITOTRIOSIDASE 1
(Homo
sapiens)		4 / 7TRP A  99
GLY A 187
ASP A 213
ARG A 269
None
0.80A23.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ARR_A_PNXA606_1
(CHITINASE A)		2g5t DIPEPTIDYL PEPTIDASE
4
(Homo
sapiens)		4 / 7GLY A 335
ASP A 329
TYR A 330
ARG A 310
None
1.12A21.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ARR_A_PNXA606_1
(CHITINASE A)		2pb7 E3 UBIQUITIN-PROTEIN
LIGASE UHRF1
(Homo
sapiens)		4 / 7GLY A 557
ASP A 583
TYR A 559
ARG A 528
None
1.30A20.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ARR_A_PNXA606_1
(CHITINASE A)		2pxx UNCHARACTERIZED
PROTEIN MGC2408
(Homo
sapiens)		4 / 7TRP A  41
GLY A 139
LYS A  17
ASP A 134
SAH  A 301 (-3.9A)
None
None
None
0.98A18.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ARR_A_PNXA606_1
(CHITINASE A)		2q3z TRANSGLUTAMINASE 2
(Homo
sapiens)		4 / 7GLY A 183
ASP A 259
TRP A 254
ARG A 263
None
0.80A21.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ARR_A_PNXA606_1
(CHITINASE A)		2xst LIPOCALIN 15
(Homo
sapiens)		4 / 7GLY A 105
ASP A 108
TYR A 106
ARG A 110
None
1.21A13.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ARR_A_PNXA606_1
(CHITINASE A)		2xyc NEURAL CELL ADHESION
MOLECULE 2
(Homo
sapiens)		4 / 7GLY A 471
ASP A 437
TYR A 473
ARG A 435
PO4  A1505 (-3.4A)
NAG  A1502 (-3.2A)
PO4  A1506 (-4.7A)
NAG  A1502 (-3.7A)
1.26A19.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ARR_A_PNXA606_1
(CHITINASE A)		3btz ALPHA-KETOGLUTARATE-
DEPENDENT
DIOXYGENASE ALKB
HOMOLOG 2
(Homo
sapiens)		4 / 7TRP A 234
GLY A 204
ASP A 201
ARG A 209
None
1.27A16.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ARR_A_PNXA606_1
(CHITINASE A)		4kxb GLUTAMYL
AMINOPEPTIDASE
(Homo
sapiens)		4 / 7GLY A 194
ASP A 113
TYR A 115
ARG A 205
None
1.17A20.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ARR_A_PNXA606_1
(CHITINASE A)		4pw5 E3 UBIQUITIN-PROTEIN
LIGASE UHRF2
(Homo
sapiens)		4 / 7GLY A 586
ASP A 613
TYR A 588
ARG A 557
None
1.24A16.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ARR_A_PNXA606_1
(CHITINASE A)		4wxu MYOCILIN
(Homo
sapiens)		4 / 7GLY A 292
ASP A 289
TRP A 489
ARG A 287
None
1.20A20.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ARR_A_PNXA606_1
(CHITINASE A)		5e84 78 KDA
GLUCOSE-REGULATED
PROTEIN
(Homo
sapiens)		4 / 7GLY A 210
LYS A 213
ASP A 357
TYR A 209
None
1.34A23.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ARR_A_PNXA606_1
(CHITINASE A)		5iry DESMOCOLLIN-1
(Homo
sapiens)		4 / 7GLY A 167
LYS A 129
TYR A 147
ARG A 144
None
1.25A22.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ARR_A_PNXA607_1
(CHITINASE A)		1n26 IL-6 RECEPTOR ALPHA
CHAIN
(Homo
sapiens)		4 / 7VAL A 179
SER A 177
THR A  17
LEU A  90
None
1.19A17.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ARR_A_PNXA607_1
(CHITINASE A)		1tow FATTY ACID-BINDING
PROTEIN, ADIPOCYTE
(Homo
sapiens)		4 / 7VAL A  80
SER A  82
HIS A  93
THR A  74
None
0.60A12.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ARR_A_PNXA607_1
(CHITINASE A)		1ysx SERUM ALBUMIN
(Homo
sapiens)		4 / 7VAL A 418
SER A 470
HIS A 464
THR A 422
None
4EB  A1000 ( 4.4A)
4EB  A1000 (-2.7A)
4EB  A1000 (-3.9A)
1.17A15.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ARR_A_PNXA607_1
(CHITINASE A)		2qq2 CYTOSOLIC ACYL
COENZYME A THIOESTER
HYDROLASE
(Homo
sapiens)		4 / 7VAL A 235
HIS A 222
THR A 240
LEU A 243
None
0.77A16.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ARR_A_PNXA607_1
(CHITINASE A)		2qyk CYCLIC AMP-SPECIFIC
PHOSPHODIESTERASE
HSPDE4A10
(Homo
sapiens)		4 / 7VAL A 380
SER A 532
THR A 384
LEU A 387
None
1.21A18.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ARR_A_PNXA607_1
(CHITINASE A)		3o57 CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4B
(Homo
sapiens)		4 / 7VAL A 242
SER A 394
THR A 246
LEU A 249
None
1.20A20.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ARR_A_PNXA607_1
(CHITINASE A)		3obz PHYTANOYL-COA
DIOXYGENASE
DOMAIN-CONTAINING
PROTEIN 1
(Homo
sapiens)		4 / 7HIS A 110
THR A 281
LEU A 284
TRP A 277
None
1.15A18.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ARR_A_PNXA607_1
(CHITINASE A)		3rc0 N-LYSINE
METHYLTRANSFERASE
SETD6
(Homo
sapiens)		4 / 7VAL A 318
SER A 419
THR A 370
LEU A 371
None
1.22A19.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ARR_A_PNXA607_1
(CHITINASE A)		3wbg FATTY ACID-BINDING
PROTEIN, HEART
(Homo
sapiens)		4 / 7VAL A  80
SER A  82
HIS A  93
THR A  74
None
0.50A15.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ARR_A_PNXA607_1
(CHITINASE A)		4a60 FATTY ACID-BINDING
PROTEIN 9 TESTIS
LIPID-BINDING
PROTEIN, TLBP,
TESTIS-TYPE FATTY
ACID-BINDING
PROTEIN, T-FABP
(Homo
sapiens)		4 / 7VAL A  81
SER A  83
HIS A  94
THR A  75
None
None
None
EDO  A1134 ( 4.9A)
0.56A14.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ARR_A_PNXA607_1
(CHITINASE A)		4fww MACROPHAGE-STIMULATI
NG PROTEIN RECEPTOR
(Homo
sapiens)		4 / 7SER A 134
HIS A 146
THR A  93
LEU A  91
ACT  A 610 (-3.1A)
None
ACT  A 610 (-3.7A)
None
1.21A20.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ARR_A_PNXA607_1
(CHITINASE A)		4nns FATTY ACID-BINDING
PROTEIN, ADIPOCYTE
(Homo
sapiens)		4 / 7VAL A  80
SER A  82
HIS A  93
THR A  74
None
0.57A14.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ARR_A_PNXA607_1
(CHITINASE A)		4qci ANTI-PDGF-BB
ANTIBODY - LIGHT
CHAIN
(Homo
sapiens)		4 / 7SER A 184
HIS A 185
THR A 178
LEU A 177
None
1.20A14.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ARR_A_PNXA607_1
(CHITINASE A)		4qn1 E3 UBIQUITIN-PROTEIN
LIGASE SHPRH
(Homo
sapiens)		4 / 7SER A1053
HIS A1057
THR A1400
LEU A1403
None
1.14A20.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ARR_A_PNXA607_1
(CHITINASE A)		4wzi CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4B
(Homo
sapiens)		4 / 7VAL A 414
SER A 566
THR A 418
LEU A 421
None
1.20A22.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ARR_A_PNXA607_1
(CHITINASE A)		4zg7 ECTONUCLEOTIDE
PYROPHOSPHATASE/PHOS
PHODIESTERASE FAMILY
MEMBER 2
(Homo
sapiens)		4 / 7SER A 620
HIS A 615
THR A 700
LEU A 698
None
1.19A20.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ARR_A_PNXA607_1
(CHITINASE A)		5b29 FATTY ACID-BINDING
PROTEIN, HEART
(Homo
sapiens)		4 / 7VAL A  80
SER A  82
HIS A  93
THR A  74
None
0.55A13.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ARR_A_PNXA607_1
(CHITINASE A)		5ec3 4-HYDROXYPHENYLPYRUV
ATE DIOXYGENASE
(Homo
sapiens)		4 / 7VAL A  70
SER A  21
HIS A  20
LEU A 157
VAL  A  70 ( 0.6A)
SER  A  21 ( 0.0A)
HIS  A  20 ( 1.0A)
LEU  A 157 ( 0.6A)
1.07A23.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ARR_A_PNXA607_1
(CHITINASE A)		5jo5 10E8 GLV
(Homo
sapiens)		4 / 7SER L 187
HIS L 188
THR L 181
LEU L 180
None
1.22A16.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ARR_A_PNXA607_1
(CHITINASE A)		5lph CENTROSOMAL PROTEIN
OF 104 KDA
(Homo
sapiens)		4 / 7VAL A 485
SER A 500
THR A 529
LEU A 533
None
1.09A18.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ARR_A_PNXA607_1
(CHITINASE A)		5m76 LIGHT CHAIN DIMER
(Homo
sapiens)		4 / 7SER A 190
HIS A 191
THR A 184
LEU A 183
None
1.22A17.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ARR_A_PNXA607_1
(CHITINASE A)		5ohj CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4B
(Homo
sapiens)		4 / 7VAL A 414
SER A 566
THR A 418
LEU A 421
None
1.21A10.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ARR_A_PNXA607_1
(CHITINASE A)		5toa ESTROGEN RECEPTOR
BETA
(Homo
sapiens)		4 / 7VAL A 485
THR A 299
LEU A 298
TRP A 335
None
None
EST  A 601 (-4.1A)
None
1.03A16.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ARR_A_PNXA607_1
(CHITINASE A)		6azp MYELOPEROXIDASE
(Homo
sapiens)		4 / 7TRP A 679
VAL A 337
THR A 458
LEU A 463
None
1.18A9.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ARU_A_PNXA606_1
(CHITINASE A)		1hkk CHITOTRIOSIDASE-1
(Homo
sapiens)		4 / 7GLY A 187
ASP A 213
TRP A 218
ARG A 269
AMI  A1391 (-3.3A)
AMI  A1388 ( 2.9A)
NAA  A1390 (-3.2A)
NAA  A1389 (-3.2A)
0.34A25.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ARU_A_PNXA606_1
(CHITINASE A)		1r47 ALPHA-GALACTOSIDASE
A
(Homo
sapiens)		4 / 7PHE A 273
GLY A 271
ASP A 299
ARG A 301
None
1.20A19.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ARU_A_PNXA606_1
(CHITINASE A)		1wb0 CHITOTRIOSIDASE 1
(Homo
sapiens)		4 / 7GLY A 187
ASP A 213
TRP A 218
ARG A 269
None
0.55A23.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ARU_A_PNXA606_1
(CHITINASE A)		2q3z TRANSGLUTAMINASE 2
(Homo
sapiens)		4 / 7GLY A 183
ASP A 259
TRP A 254
ARG A 263
None
0.87A21.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ARU_A_PNXA606_1
(CHITINASE A)		2xst LIPOCALIN 15
(Homo
sapiens)		4 / 7GLY A 105
ASP A 108
TYR A 106
ARG A 110
None
1.24A13.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ARU_A_PNXA606_1
(CHITINASE A)		4kxb GLUTAMYL
AMINOPEPTIDASE
(Homo
sapiens)		4 / 7GLY A 194
ASP A 113
TYR A 115
ARG A 205
None
1.13A20.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ARU_A_PNXA606_1
(CHITINASE A)		4pw5 E3 UBIQUITIN-PROTEIN
LIGASE UHRF2
(Homo
sapiens)		4 / 7GLY A 586
ASP A 613
TYR A 588
ARG A 557
None
1.24A16.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ARU_A_PNXA606_1
(CHITINASE A)		4wxu MYOCILIN
(Homo
sapiens)		4 / 7GLY A 292
ASP A 289
TRP A 489
ARG A 287
None
1.18A20.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ARU_A_PNXA606_1
(CHITINASE A)		5epg ALDEHYDE OXIDASE
(Homo
sapiens)		4 / 7PHE A 116
GLY A  43
ASP A 601
ARG A 833
None
FES  A3002 (-3.9A)
None
None
1.26A18.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ARU_A_PNXA606_1
(CHITINASE A)		5iry DESMOCOLLIN-1
(Homo
sapiens)		4 / 7GLY A 167
LYS A 129
TYR A 147
ARG A 144
None
1.24A22.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ARU_A_PNXA606_1
(CHITINASE A)		5jz7 MEDI578 SCFV, HEAVY
CHAIN
MEDI578 SCFV, LIGHT
CHAIN
(Homo
sapiens)		4 / 7GLY C  33
ASP C 100
TRP D  96
TYR C 100
None
1.24A12.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ARU_A_PNXA607_1
(CHITINASE A)		1i16 INTERLEUKIN 16
(Homo
sapiens)		4 / 8VAL A 110
GLY A  43
GLY A  67
ALA A  68
None
0.72A13.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ARU_A_PNXA607_1
(CHITINASE A)		1ism BONE MARROW STROMAL
CELL ANTIGEN 1
(Homo
sapiens)		4 / 8GLY A 166
THR A 165
GLU A 204
GLY A 161
None
0.77A18.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ARU_A_PNXA607_1
(CHITINASE A)		1qh5 PROTEIN
(HYDROXYACYLGLUTATHI
ONE HYDROLASE)
(Homo
sapiens)		4 / 8GLY A  83
GLU A  64
GLY A  61
ALA A  60
None
0.61A19.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ARU_A_PNXA607_1
(CHITINASE A)		2dix INTERFERON-INDUCIBLE
DOUBLE STRANDED
RNA-DEPENDENT
PROTEIN KINASE
ACTIVATOR A
(Homo
sapiens)		5 / 8GLY A  56
THR A  57
GLU A  55
GLY A  54
ALA A  62
None
1.42A8.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ARU_A_PNXA607_1
(CHITINASE A)		2ehr INAD-LIKE PROTEIN
(Homo
sapiens)		4 / 8VAL A 102
GLY A  30
GLY A  64
ALA A  63
None
0.69A11.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ARU_A_PNXA607_1
(CHITINASE A)		2j6l ALDEHYDE
DEHYDROGENASE FAMILY
7 MEMBER A1
(Homo
sapiens)		4 / 8VAL A 369
GLY A 389
THR A 388
GLY A 365
None
0.67A21.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ARU_A_PNXA607_1
(CHITINASE A)		2n4p TAR DNA-BINDING
PROTEIN 43
(Homo
sapiens)		4 / 8GLY A  36
THR A  37
GLY A  79
ALA A  75
None
0.64A9.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ARU_A_PNXA607_1
(CHITINASE A)		2nvu MALTOSE BINDING
PROTEIN/NEDD8-ACTIVA
TING ENZYME E1
CATALYTIC SUBUNIT
CHIMERA
(Homo
sapiens)		4 / 8VAL B1344
GLY B1183
GLY B1188
ALA B1189
None
0.74A22.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ARU_A_PNXA607_1
(CHITINASE A)		3cem GLYCOGEN
PHOSPHORYLASE, LIVER
FORM
(Homo
sapiens)		5 / 8GLY A 675
THR A 676
GLU A 672
GLY A 694
ALA A 695
PLP  A 832 ( 3.3A)
PLP  A 832 (-3.8A)
NBG  A   1 (-3.5A)
None
None
1.14A21.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ARU_A_PNXA608_1
(CHITINASE A)		1exz STEM CELL FACTOR
(Homo
sapiens)		4 / 6SER A 133
ALA A 132
HIS A  42
ASP A  97
None
1.33A11.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ARU_A_PNXA608_1
(CHITINASE A)		1q3x MANNAN-BINDING
LECTIN SERINE
PROTEASE 2
(Homo
sapiens)		4 / 6TRP A 573
SER A 571
ALA A 570
ASP A 632
None
1.08A21.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ARU_A_PNXA608_1
(CHITINASE A)		1spj KALLIKREIN 1
(Homo
sapiens)		4 / 6TRP A 141
SER A 139
ALA A 138
ASP A 194
None
1.15A17.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ARU_A_PNXA608_1
(CHITINASE A)		2e0t DUAL SPECIFICITY
PHOSPHATASE 26
(Homo
sapiens)		4 / 6ASN A  78
ALA A  77
HIS A 151
ASP A  73
None
1.35A12.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ARU_A_PNXA608_1
(CHITINASE A)		2nvu MALTOSE BINDING
PROTEIN/NEDD8-ACTIVA
TING ENZYME E1
CATALYTIC SUBUNIT
CHIMERA
(Homo
sapiens)		4 / 6ASN B1268
SER B1271
ALA B1270
ASP B1056
None
1.24A22.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ARU_A_PNXA608_1
(CHITINASE A)		3gbn FAB HEAVY CHAIN
(Homo
sapiens)		4 / 6TRP H 103
SER H  35
ALA H  33
HIS H  95
None
1.38A15.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ARU_A_PNXA608_1
(CHITINASE A)		3p8c ABL INTERACTOR 2
NCK-ASSOCIATED
PROTEIN 1
(Homo
sapiens)		4 / 6ASN F  91
SER F  88
HIS B 945
ASP B 944
None
1.17A13.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ARU_A_PNXA608_1
(CHITINASE A)		4fdd RNA-BINDING PROTEIN
FUS
TRANSPORTIN-1
(Homo
sapiens)		4 / 6ASN A 727
SER A 686
ALA A 689
ASP B 512
None
1.37A21.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ARU_A_PNXA608_1
(CHITINASE A)		4fxg MANNAN-BINDING
LECTIN SERINE
PROTEASE 2 B CHAIN
(Homo
sapiens)		4 / 6TRP H 573
SER H 571
ALA H 570
ASP H 632
None
1.17A18.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ARU_A_PNXA608_1
(CHITINASE A)		4hcr PF-547659 HEAVY
CHAIN
(Homo
sapiens)		4 / 6ASN H 215
SER H 214
HIS H 211
ASP H 210
None
1.19A16.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ARU_A_PNXA608_1
(CHITINASE A)		4nff KALLIKREIN-2
(Homo
sapiens)		4 / 6TRP A 141
SER A 139
ALA A 138
ASP A 194
None
1.22A17.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ARU_A_PNXA608_1
(CHITINASE A)		4y2e DUAL SPECIFICITY
PROTEIN PHOSPHATASE
7
(Homo
sapiens)		4 / 6ASN A 274
SER A 204
HIS A 202
ASP A 201
None
None
None
PO4  A 301 (-3.2A)
1.38A14.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ARU_A_PNXA608_1
(CHITINASE A)		5gtj DUAL SPECIFICITY
PROTEIN PHOSPHATASE
26
(Homo
sapiens)		4 / 6ASN A  78
ALA A  77
HIS A 151
ASP A  73
None
1.30A15.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ARU_A_PNXA608_1
(CHITINASE A)		5hcc COMPLEMENT C5
(Homo
sapiens)		4 / 6TRP A1077
ASN A1121
SER A1122
ALA A1074
None
1.30A18.61
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3TVX_A_PNXA902_1
(CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4A)		1soj CGMP-INHIBITED
3',5'-CYCLIC
PHOSPHODIESTERASE B
(Homo
sapiens)		6 / 9TYR A 736
PRO A 941
THR A 952
ILE A 955
GLN A 988
PHE A 991
IBM  A2111 (-4.5A)
None
IBM  A2111 ( 4.8A)
IBM  A2111 (-4.2A)
IBM  A2111 (-3.3A)
IBM  A2111 (-3.6A)
0.53A30.53
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3TVX_A_PNXA902_1
(CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4A)		1zkl HIGH-AFFINITY
CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 7A
(Homo
sapiens)		5 / 9TYR A 211
ASN A 365
PRO A 366
GLN A 413
PHE A 416
IBM  A 503 (-4.6A)
IBM  A 503 ( 4.7A)
None
IBM  A 503 (-3.0A)
IBM  A 503 (-3.4A)
0.56A33.42
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3TVX_A_PNXA902_1
(CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4A)		2qyk CYCLIC AMP-SPECIFIC
PHOSPHODIESTERASE
HSPDE4A10
(Homo
sapiens)		9 / 9TYR A 371
LEU A 531
ASN A 533
PRO A 534
THR A 545
ILE A 548
MET A 569
GLN A 581
PHE A 584
NPV  A   3 (-4.4A)
None
NPV  A   3 (-4.4A)
None
NPV  A   3 ( 4.7A)
NPV  A   3 (-3.8A)
NPV  A   3 (-3.1A)
NPV  A   3 (-3.1A)
NPV  A   3 (-3.3A)
0.28A98.82
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3TVX_A_PNXA902_1
(CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4A)		2qym PHOSPHODIESTERASE 4C
(Homo
sapiens)		7 / 9TYR A 281
LEU A 441
ASN A 443
PRO A 444
THR A 455
ILE A 458
PHE A 494
None
0.73A83.88
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3TVX_A_PNXA902_1
(CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4A)		3ecn HIGH AFFINITY
CAMP-SPECIFIC AND
IBMX-INSENSITIVE
3',5'-CYCLIC
PHOSPHODIESTERASE 8A
(Homo
sapiens)		6 / 9TYR A 555
ASN A 729
PRO A 730
ILE A 744
GLN A 778
PHE A 781
None
None
None
IBM  A   3 (-4.3A)
IBM  A   3 (-3.4A)
IBM  A   3 (-3.5A)
0.36A34.09
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3TVX_A_PNXA902_1
(CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4A)		3g4g CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4D
(Homo
sapiens)		8 / 9TYR A 325
LEU A 485
ASN A 487
PRO A 488
THR A 499
ILE A 502
GLN A 535
PHE A 538
None
None
D71  A 901 (-4.5A)
None
D71  A 901 (-3.6A)
D71  A 901 (-4.1A)
D71  A 901 (-3.1A)
D71  A 901 (-3.9A)
0.42A70.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TVX_A_PNXA902_1
(CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4A)		3ibj CGMP-DEPENDENT
3',5'-CYCLIC
PHOSPHODIESTERASE
(Homo
sapiens)		5 / 9TYR A 655
LEU A 809
ILE A 826
GLN A 859
PHE A 862
None
0.76A18.26
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3TVX_A_PNXA902_1
(CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4A)		3o57 CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4B
(Homo
sapiens)		6 / 9PRO A 396
THR A 407
ILE A 410
MET A 431
GLN A 443
PHE A 446
ZG2  A 506 ( 4.5A)
ZG2  A 506 (-4.3A)
ZG2  A 506 (-4.4A)
ZG2  A 506 (-3.4A)
ZG2  A 506 (-3.3A)
ZG2  A 506 (-3.6A)
0.74A86.83
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3TVX_A_PNXA902_1
(CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4A)		3o57 CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4B
(Homo
sapiens)		8 / 9TYR A 233
LEU A 393
ASN A 395
PRO A 396
THR A 407
ILE A 410
GLN A 443
PHE A 446
None
None
ZG2  A 506 (-4.3A)
ZG2  A 506 ( 4.5A)
ZG2  A 506 (-4.3A)
ZG2  A 506 (-4.4A)
ZG2  A 506 (-3.3A)
ZG2  A 506 (-3.6A)
0.40A86.83
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3TVX_A_PNXA902_1
(CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4A)		3sl5 CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4D
(Homo
sapiens)		9 / 9TYR A 159
LEU A 319
ASN A 321
PRO A 322
THR A 333
ILE A 336
MET A 357
GLN A 369
PHE A 372
TYR  A 159 (-1.3A)
LEU  A 319 ( 0.6A)
ASN  A 321 (-0.6A)
PRO  A 322 (-1.1A)
THR  A 333 ( 0.8A)
ILE  A 336 ( 0.4A)
MET  A 357 (-0.0A)
GLN  A 369 (-0.6A)
PHE  A 372 (-1.3A)
0.46A85.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TVX_A_PNXA902_1
(CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4A)		3ui7 CAMP AND
CAMP-INHIBITED CGMP
3',5'-CYCLIC
PHOSPHODIESTERASE
10A
(Homo
sapiens)		6 / 9TYR A 524
LEU A 675
ILE A 692
MET A 713
GLN A 726
PHE A 729
C1L  A   1 ( 4.8A)
C1L  A   1 (-4.3A)
C1L  A   1 (-4.3A)
C1L  A   1 (-3.7A)
C1L  A   1 (-2.9A)
C1L  A   1 (-3.5A)
1.04A28.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TVX_A_PNXA902_1
(CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4A)		4htz CGMP-DEPENDENT
3',5'-CYCLIC
PHOSPHODIESTERASE
(Homo
sapiens)		5 / 9TYR A 655
LEU A 809
ILE A 826
GLN A 859
PHE A 862
None
0.54A28.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TVX_A_PNXA902_1
(CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4A)		4htz CGMP-DEPENDENT
3',5'-CYCLIC
PHOSPHODIESTERASE
(Homo
sapiens)		5 / 9TYR A 655
LEU A 809
ILE A 826
MET A 847
PHE A 862
None
0.91A28.98
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3TVX_A_PNXA902_1
(CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4A)		4wzi CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4B
(Homo
sapiens)		5 / 9ASN A 567
THR A 579
ILE A 582
MET A 603
GLN A 615
None
1.03A50.26
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3TVX_A_PNXA902_1
(CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4A)		4wzi CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4B
(Homo
sapiens)		8 / 9TYR A 405
LEU A 565
ASN A 567
PRO A 568
THR A 579
ILE A 582
GLN A 615
PHE A 618
None
0.56A50.26
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3TVX_A_PNXA902_1
(CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4A)		5b25 CALCIUM/CALMODULIN-D
EPENDENT
3',5'-CYCLIC
NUCLEOTIDE
PHOSPHODIESTERASE 1B
(Homo
sapiens)		5 / 9TYR A 222
PRO A 374
THR A 385
GLN A 421
PHE A 424
None
None
None
4QJ  A 603 (-3.0A)
4QJ  A 603 (-3.5A)
0.47A37.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TVX_A_PNXA902_1
(CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4A)		5ohj CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4B
(Homo
sapiens)		9 / 9TYR A 405
LEU A 565
ASN A 567
PRO A 568
THR A 579
ILE A 582
MET A 603
GLN A 615
PHE A 618
None
9VE  A 801 (-4.7A)
9VE  A 801 (-4.1A)
9VE  A 801 (-3.9A)
9VE  A 801 (-4.1A)
9VE  A 801 (-4.1A)
9VE  A 801 (-3.6A)
9VE  A 801 (-3.2A)
9VE  A 801 (-3.9A)
0.60A13.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TVX_A_PNXA902_1
(CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4A)		5wh6 CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4D
(Homo
sapiens)		9 / 9TYR A 159
LEU A 319
ASN A 321
PRO A 322
THR A 333
ILE A 336
MET A 357
GLN A 369
PHE A 372
AKJ  A 601 ( 4.7A)
AKJ  A 601 ( 4.6A)
AKJ  A 601 (-4.3A)
AKJ  A 601 (-3.9A)
AKJ  A 601 (-4.1A)
AKJ  A 601 (-3.8A)
AKJ  A 601 (-3.4A)
AKJ  A 601 (-3.0A)
AKJ  A 601 (-4.1A)
0.48Aundetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TVX_B_PNXB902_1
(CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4A)		1c25 CDC25A
(Homo
sapiens)		4 / 7TYR A 463
ILE A 425
PHE A 379
PHE A 372
None
1.13A17.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TVX_B_PNXB902_1
(CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4A)		1gtu GLUTATHIONE
S-TRANSFERASE
(Homo
sapiens)		4 / 7TYR A 126
ILE A 113
PHE A 119
PHE A 208
None
0.94A21.08
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3TVX_B_PNXB902_1
(CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4A)		1soj CGMP-INHIBITED
3',5'-CYCLIC
PHOSPHODIESTERASE B
(Homo
sapiens)		5 / 7TYR A 736
ILE A 955
PHE A 959
GLN A 988
PHE A 991
IBM  A2111 (-4.5A)
IBM  A2111 (-4.2A)
None
IBM  A2111 (-3.3A)
IBM  A2111 (-3.6A)
0.59A30.53
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3TVX_B_PNXB902_1
(CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4A)		1zkl HIGH-AFFINITY
CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 7A
(Homo
sapiens)		5 / 7TYR A 211
ASN A 365
PHE A 384
GLN A 413
PHE A 416
IBM  A 503 (-4.6A)
IBM  A 503 ( 4.7A)
IBM  A 503 (-4.5A)
IBM  A 503 (-3.0A)
IBM  A 503 (-3.4A)
0.57A33.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TVX_B_PNXB902_1
(CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4A)		2pz1 RHO GUANINE
NUCLEOTIDE EXCHANGE
FACTOR 4
(Homo
sapiens)		4 / 7ILE A 329
PHE A 330
GLN A 325
PHE A 321
None
1.18A21.99
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3TVX_B_PNXB902_1
(CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4A)		2qyk CYCLIC AMP-SPECIFIC
PHOSPHODIESTERASE
HSPDE4A10
(Homo
sapiens)		7 / 7TYR A 371
ASN A 533
ILE A 548
PHE A 552
MET A 569
GLN A 581
PHE A 584
NPV  A   3 (-4.4A)
NPV  A   3 (-4.4A)
NPV  A   3 (-3.8A)
NPV  A   3 (-4.8A)
NPV  A   3 (-3.1A)
NPV  A   3 (-3.1A)
NPV  A   3 (-3.3A)
0.24A98.82
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3TVX_B_PNXB902_1
(CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4A)		2qym PHOSPHODIESTERASE 4C
(Homo
sapiens)		4 / 7TYR A 281
ASN A 443
ILE A 458
PHE A 494
None
0.57A83.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TVX_B_PNXB902_1
(CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4A)		2ygn WNT INHIBITORY
FACTOR 1
(Homo
sapiens)		4 / 7ASN A 170
ILE A 172
PHE A 174
GLN A  74
None
1.03A17.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TVX_B_PNXB902_1
(CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4A)		2ygo WNT INHIBITORY
FACTOR 1
(Homo
sapiens)		4 / 7ASN A 170
ILE A 172
PHE A 174
GLN A  74
None
1.13A17.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TVX_B_PNXB902_1
(CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4A)		2ygq WNT INHIBITORY
FACTOR 1
(Homo
sapiens)		4 / 7ASN A 170
ILE A 172
PHE A 174
GLN A  74
None
1.15A19.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TVX_B_PNXB902_1
(CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4A)		3b2r CGMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE
(Homo
sapiens)		4 / 7TYR A 612
PHE A 786
GLN A 817
PHE A 820
VDN  A   1 (-4.8A)
None
VDN  A   1 (-3.0A)
VDN  A   1 (-3.6A)
0.53A29.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TVX_B_PNXB902_1
(CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4A)		3bjc CGMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE
(Homo
sapiens)		4 / 7TYR A 612
PHE A 786
GLN A 817
PHE A 820
None
WAN  A 901 (-4.8A)
WAN  A 901 (-3.1A)
WAN  A 901 (-3.7A)
0.40A16.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TVX_B_PNXB902_1
(CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4A)		3d3l ARACHIDONATE
12-LIPOXYGENASE,
12S-TYPE
(Homo
sapiens)		4 / 7TYR A 614
ILE A 390
PHE A 386
MET A 376
None
0.95A21.14
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3TVX_B_PNXB902_1
(CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4A)		3ecn HIGH AFFINITY
CAMP-SPECIFIC AND
IBMX-INSENSITIVE
3',5'-CYCLIC
PHOSPHODIESTERASE 8A
(Homo
sapiens)		5 / 7TYR A 555
ASN A 729
ILE A 744
GLN A 778
PHE A 781
None
None
IBM  A   3 (-4.3A)
IBM  A   3 (-3.4A)
IBM  A   3 (-3.5A)
0.38A34.09
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3TVX_B_PNXB902_1
(CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4A)		3g4g CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4D
(Homo
sapiens)		6 / 7TYR A 325
ASN A 487
ILE A 502
PHE A 506
GLN A 535
PHE A 538
None
D71  A 901 (-4.5A)
D71  A 901 (-4.1A)
D71  A 901 (-4.8A)
D71  A 901 (-3.1A)
D71  A 901 (-3.9A)
0.48A70.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TVX_B_PNXB902_1
(CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4A)		3ibj CGMP-DEPENDENT
3',5'-CYCLIC
PHOSPHODIESTERASE
(Homo
sapiens)		4 / 7TYR A 655
ILE A 826
GLN A 859
PHE A 862
None
0.59A18.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TVX_B_PNXB902_1
(CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4A)		3n2z LYSOSOMAL PRO-X
CARBOXYPEPTIDASE
(Homo
sapiens)		4 / 7TYR B 411
ILE B 407
PHE B 209
MET B 369
None
1.17A23.09
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3TVX_B_PNXB902_1
(CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4A)		3o57 CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4B
(Homo
sapiens)		5 / 7ASN A 395
ILE A 410
MET A 431
GLN A 443
PHE A 446
ZG2  A 506 (-4.3A)
ZG2  A 506 (-4.4A)
ZG2  A 506 (-3.4A)
ZG2  A 506 (-3.3A)
ZG2  A 506 (-3.6A)
0.88A86.83
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3TVX_B_PNXB902_1
(CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4A)		3o57 CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4B
(Homo
sapiens)		6 / 7TYR A 233
ASN A 395
ILE A 410
PHE A 414
GLN A 443
PHE A 446
None
ZG2  A 506 (-4.3A)
ZG2  A 506 (-4.4A)
ZG2  A 506 (-4.4A)
ZG2  A 506 (-3.3A)
ZG2  A 506 (-3.6A)
0.51A86.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TVX_B_PNXB902_1
(CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4A)		3pkj NAD-DEPENDENT
DEACETYLASE
SIRTUIN-6
(Homo
sapiens)		4 / 7ASN A 112
ILE A  59
PHE A  80
PHE A  62
None
None
None
A2N  A1000 (-3.8A)
1.20A22.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TVX_B_PNXB902_1
(CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4A)		3rze HISTAMINE H1
RECEPTOR, LYSOZYME
CHIMERA
(Escherichia
virus
T4;
Homo
sapiens)		4 / 7ASN A 198
ILE A 115
PHE A 424
PHE A 432
D7V  A1201 (-4.6A)
D7V  A1201 (-3.8A)
None
5EH  A1200 ( 4.3A)
0.94A21.44
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3TVX_B_PNXB902_1
(CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4A)		3sl5 CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4D
(Homo
sapiens)		7 / 7TYR A 159
ASN A 321
ILE A 336
PHE A 340
MET A 357
GLN A 369
PHE A 372
TYR  A 159 (-1.3A)
ASN  A 321 (-0.6A)
ILE  A 336 ( 0.4A)
PHE  A 340 (-1.3A)
MET  A 357 (-0.0A)
GLN  A 369 (-0.6A)
PHE  A 372 (-1.3A)
0.52A85.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TVX_B_PNXB902_1
(CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4A)		3ui7 CAMP AND
CAMP-INHIBITED CGMP
3',5'-CYCLIC
PHOSPHODIESTERASE
10A
(Homo
sapiens)		6 / 7TYR A 524
ILE A 692
PHE A 696
MET A 713
GLN A 726
PHE A 729
C1L  A   1 ( 4.8A)
C1L  A   1 (-4.3A)
C1L  A   1 ( 4.7A)
C1L  A   1 (-3.7A)
C1L  A   1 (-2.9A)
C1L  A   1 (-3.5A)
1.03A28.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TVX_B_PNXB902_1
(CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4A)		3zg6 NAD-DEPENDENT
PROTEIN DEACETYLASE
SIRTUIN-6
(Homo
sapiens)		4 / 7ASN A 112
ILE A  59
PHE A  80
PHE A  62
None
None
None
APR  A1296 (-3.6A)
1.27A21.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TVX_B_PNXB902_1
(CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4A)		4htz CGMP-DEPENDENT
3',5'-CYCLIC
PHOSPHODIESTERASE
(Homo
sapiens)		6 / 7TYR A 655
ILE A 826
PHE A 830
MET A 847
GLN A 859
PHE A 862
None
0.82A28.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TVX_B_PNXB902_1
(CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4A)		4nen INTEGRIN ALPHA-X
(Homo
sapiens)		4 / 7TYR A 265
ILE A 234
GLN A 131
PHE A 162
None
1.12A15.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TVX_B_PNXB902_1
(CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4A)		4uow OBSCURIN
TITIN
(Homo
sapiens)		4 / 7ASN 0  93
ILE 0  14
PHE 1  92
GLN 1  47
None
None
CL  0 201 (-4.8A)
None
1.22A14.38
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3TVX_B_PNXB902_1
(CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4A)		4wzi CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4B
(Homo
sapiens)		5 / 7ASN A 567
ILE A 582
PHE A 586
MET A 603
GLN A 615
None
1.01A50.26
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3TVX_B_PNXB902_1
(CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4A)		4wzi CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4B
(Homo
sapiens)		6 / 7TYR A 405
ASN A 567
ILE A 582
PHE A 586
GLN A 615
PHE A 618
None
0.62A50.26
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3TVX_B_PNXB902_1
(CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4A)		5b25 CALCIUM/CALMODULIN-D
EPENDENT
3',5'-CYCLIC
NUCLEOTIDE
PHOSPHODIESTERASE 1B
(Homo
sapiens)		4 / 7TYR A 222
PHE A 392
GLN A 421
PHE A 424
None
GOL  A 607 (-3.9A)
4QJ  A 603 (-3.0A)
4QJ  A 603 (-3.5A)
0.44A37.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TVX_B_PNXB902_1
(CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4A)		5ohj CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4B
(Homo
sapiens)		7 / 7TYR A 405
ASN A 567
ILE A 582
PHE A 586
MET A 603
GLN A 615
PHE A 618
None
9VE  A 801 (-4.1A)
9VE  A 801 (-4.1A)
9VE  A 801 (-3.6A)
9VE  A 801 (-3.6A)
9VE  A 801 (-3.2A)
9VE  A 801 (-3.9A)
0.58A13.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TVX_B_PNXB902_1
(CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4A)		5wh6 CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4D
(Homo
sapiens)		7 / 7TYR A 159
ASN A 321
ILE A 336
PHE A 340
MET A 357
GLN A 369
PHE A 372
AKJ  A 601 ( 4.7A)
AKJ  A 601 (-4.3A)
AKJ  A 601 (-3.8A)
AKJ  A 601 (-4.5A)
AKJ  A 601 (-3.4A)
AKJ  A 601 (-3.0A)
AKJ  A 601 (-4.1A)
0.33Aundetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TVX_B_PNXB902_1
(CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4A)		5xnp LEUCINE-RICH REPEAT
AND FIBRONECTIN
TYPE-III
DOMAIN-CONTAINING
PROTEIN 5
(Homo
sapiens)		4 / 7ASN A  85
ILE A  66
PHE A  95
MET A 118
None
1.27A11.99