POTENTIAL TARGETS FROM HUMAN (RESULTS FROM SUB-STRUCTURAL SIMILARITY SEARCHES)
1) User may click on the DrReposER ID (the second column) to get information on the binding sites and drug molecule.
2) Click View (the second last column) to view matched residues and superposition in the NGL viewer (upper right part).
3) User may also click on the Dock (the last column) to get script for molecular docking in UCSF Chimera through AutoDock Vina.

DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Seq.
Identity (%)		 View Dock
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2X7H_A_PFNA1372_1
(ZINC-BINDING ALCOHOL
DEHYDROGENASE
DOMAIN-CONTAINING
PROTEIN 2)		2wek ZINC-BINDING ALCOHOL
DEHYDROGENASE
DOMAIN-CONTAINING
PROTEIN 2
(Homo
sapiens)		6 / 11TYR A 161
LEU A 164
LEU A 170
LEU A 192
LYS A 195
MET A 322
DIF  A1376 (-4.3A)
DIF  A1376 ( 4.5A)
DIF  A1376 ( 4.5A)
DIF  A1376 (-4.4A)
None
DIF  A1376 (-3.6A)
0.15A97.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X7H_A_PFNA1372_1
(ZINC-BINDING ALCOHOL
DEHYDROGENASE
DOMAIN-CONTAINING
PROTEIN 2)		3f5x CYCLIN-A2
(Homo
sapiens)		5 / 11LEU B 336
LEU B 394
LEU B 339
HIS B 404
PRO B 346
None
1.40A22.81
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2X7H_A_PFNA1374_1
(ZINC-BINDING ALCOHOL
DEHYDROGENASE
DOMAIN-CONTAINING
PROTEIN 2)		2wek ZINC-BINDING ALCOHOL
DEHYDROGENASE
DOMAIN-CONTAINING
PROTEIN 2
(Homo
sapiens)		6 / 6PRO A 144
SER A 145
LYS A 147
GLU A 149
TYR A 150
CYH A 323
None
0.21A97.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X7H_A_PFNA1374_1
(ZINC-BINDING ALCOHOL
DEHYDROGENASE
DOMAIN-CONTAINING
PROTEIN 2)		3v4y SERINE/THREONINE-PRO
TEIN PHOSPHATASE
PP1-ALPHA CATALYTIC
SUBUNIT
(Homo
sapiens)		4 / 6PRO A  82
SER A  85
LYS A  60
TYR A  87
None
1.16A23.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X7H_A_PFNA1374_1
(ZINC-BINDING ALCOHOL
DEHYDROGENASE
DOMAIN-CONTAINING
PROTEIN 2)		3wsy SORTILIN-RELATED
RECEPTOR
(Homo
sapiens)		4 / 6PRO A 410
SER A 393
TYR A 391
CYH A 362
None
1.17A20.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X7H_A_PFNA1374_1
(ZINC-BINDING ALCOHOL
DEHYDROGENASE
DOMAIN-CONTAINING
PROTEIN 2)		4cak INTEGRIN ALPHA-IIB
INTEGRIN BETA-3
(Homo
sapiens)		4 / 6PRO A 564
SER A 563
LYS B 384
GLU B 356
NAG  B3452 (-3.8A)
None
None
None
1.46A17.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X7H_A_PFNA1374_1
(ZINC-BINDING ALCOHOL
DEHYDROGENASE
DOMAIN-CONTAINING
PROTEIN 2)		6eoq DIPEPTIDYL PEPTIDASE
9
(Homo
sapiens)		4 / 6PRO A 236
SER A 283
GLU A 279
CYH A 225
None
1.27A12.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X7H_A_PFNA1375_1
(ZINC-BINDING ALCOHOL
DEHYDROGENASE
DOMAIN-CONTAINING
PROTEIN 2)		2ozo TYROSINE-PROTEIN
KINASE ZAP-70
(Homo
sapiens)		4 / 5SER A 144
TYR A 597
VAL A 149
TYR A 397
None
1.28A21.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X7H_A_PFNA1375_1
(ZINC-BINDING ALCOHOL
DEHYDROGENASE
DOMAIN-CONTAINING
PROTEIN 2)		2ql6 NICOTINAMIDE
RIBOSIDE KINASE 1
(Homo
sapiens)		4 / 5SER A   9
TYR A 154
PHE A 117
VAL A 165
None
1.01A20.16
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2X7H_A_PFNA1375_1
(ZINC-BINDING ALCOHOL
DEHYDROGENASE
DOMAIN-CONTAINING
PROTEIN 2)		2wek ZINC-BINDING ALCOHOL
DEHYDROGENASE
DOMAIN-CONTAINING
PROTEIN 2
(Homo
sapiens)		4 / 5SER A  77
PHE A  98
VAL A 155
TYR A 275
DIF  A1373 (-3.0A)
DIF  A1374 ( 3.9A)
DIF  A1373 (-4.4A)
GOL  A1380 (-3.4A)
0.22A97.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X7H_A_PFNA1375_1
(ZINC-BINDING ALCOHOL
DEHYDROGENASE
DOMAIN-CONTAINING
PROTEIN 2)		5kzn METABOTROPIC
GLUTAMATE RECEPTOR 2
(Homo
sapiens)		4 / 5SER A 164
PHE A 181
VAL A 151
TYR A 165
None
1.29A19.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X7H_A_PFNA1375_1
(ZINC-BINDING ALCOHOL
DEHYDROGENASE
DOMAIN-CONTAINING
PROTEIN 2)		5lt1 KINESIN-LIKE PROTEIN
(Homo
sapiens)		4 / 5SER A  54
TYR A  29
PHE A  33
VAL A  51
None
1.32A21.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X7H_A_PFNA1375_1
(ZINC-BINDING ALCOHOL
DEHYDROGENASE
DOMAIN-CONTAINING
PROTEIN 2)		6bsz METABOTROPIC
GLUTAMATE RECEPTOR 8
(Homo
sapiens)		4 / 5SER A 175
PHE A 192
VAL A 162
TYR A 176
None
1.36A11.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X7H_B_PFNB1372_1
(ZINC-BINDING ALCOHOL
DEHYDROGENASE
DOMAIN-CONTAINING
PROTEIN 2)		2ozo TYROSINE-PROTEIN
KINASE ZAP-70
(Homo
sapiens)		4 / 5SER A 144
TYR A 597
VAL A 149
TYR A 397
None
1.28A21.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X7H_B_PFNB1372_1
(ZINC-BINDING ALCOHOL
DEHYDROGENASE
DOMAIN-CONTAINING
PROTEIN 2)		2ql6 NICOTINAMIDE
RIBOSIDE KINASE 1
(Homo
sapiens)		4 / 5SER A   9
TYR A 154
PHE A 117
VAL A 165
None
0.99A20.16
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2X7H_B_PFNB1372_1
(ZINC-BINDING ALCOHOL
DEHYDROGENASE
DOMAIN-CONTAINING
PROTEIN 2)		2wek ZINC-BINDING ALCOHOL
DEHYDROGENASE
DOMAIN-CONTAINING
PROTEIN 2
(Homo
sapiens)		4 / 5SER A  77
PHE A  98
VAL A 155
TYR A 275
DIF  A1373 (-3.0A)
DIF  A1374 ( 3.9A)
DIF  A1373 (-4.4A)
GOL  A1380 (-3.4A)
0.26A97.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X7H_B_PFNB1372_1
(ZINC-BINDING ALCOHOL
DEHYDROGENASE
DOMAIN-CONTAINING
PROTEIN 2)		5lt1 KINESIN-LIKE PROTEIN
(Homo
sapiens)		4 / 5SER A  54
TYR A  29
PHE A  33
VAL A  51
None
1.31A21.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X7H_B_PFNB1372_1
(ZINC-BINDING ALCOHOL
DEHYDROGENASE
DOMAIN-CONTAINING
PROTEIN 2)		6bsz METABOTROPIC
GLUTAMATE RECEPTOR 8
(Homo
sapiens)		4 / 5SER A 175
PHE A 192
VAL A 162
TYR A 176
None
1.34A11.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X7H_B_PFNB1374_1
(ZINC-BINDING ALCOHOL
DEHYDROGENASE
DOMAIN-CONTAINING
PROTEIN 2)		1few SECOND
MITOCHONDRIA-DERIVED
ACTIVATOR OF
CASPASES
(Homo
sapiens)		4 / 4TYR A  95
LEU A  98
LEU A  41
HIS A 143
None
1.37A22.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X7H_B_PFNB1374_1
(ZINC-BINDING ALCOHOL
DEHYDROGENASE
DOMAIN-CONTAINING
PROTEIN 2)		1pex COLLAGENASE-3
(Homo
sapiens)		4 / 4TYR A 400
LEU A 370
LEU A 368
HIS A 405
None
1.47A17.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X7H_B_PFNB1374_1
(ZINC-BINDING ALCOHOL
DEHYDROGENASE
DOMAIN-CONTAINING
PROTEIN 2)		1srq GTPASE-ACTIVATING
PROTEIN 1
(Homo
sapiens)		4 / 4TYR A 398
LEU A 112
LEU A 105
HIS A 402
None
1.37A21.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X7H_B_PFNB1374_1
(ZINC-BINDING ALCOHOL
DEHYDROGENASE
DOMAIN-CONTAINING
PROTEIN 2)		3na0 CHOLESTEROL
SIDE-CHAIN CLEAVAGE
ENZYME,
MITOCHONDRIAL
(Homo
sapiens)		4 / 4TYR A 303
LEU A 306
LEU A 288
HIS A 295
None
1.46A21.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X7H_B_PFNB1374_1
(ZINC-BINDING ALCOHOL
DEHYDROGENASE
DOMAIN-CONTAINING
PROTEIN 2)		3v4v INTEGRIN BETA-7
(Homo
sapiens)		4 / 4TYR B 136
LEU B 135
LEU B 216
HIS B 212
None
1.46A21.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X7H_B_PFNB1374_1
(ZINC-BINDING ALCOHOL
DEHYDROGENASE
DOMAIN-CONTAINING
PROTEIN 2)		4rg6 CELL DIVISION CYCLE
PROTEIN 27 HOMOLOG
(Homo
sapiens)		4 / 4TYR A  32
LEU A  43
LEU A  44
HIS A  64
None
1.23A20.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X7H_B_PFNB1374_1
(ZINC-BINDING ALCOHOL
DEHYDROGENASE
DOMAIN-CONTAINING
PROTEIN 2)		4rg6 CELL DIVISION CYCLE
PROTEIN 27 HOMOLOG
(Homo
sapiens)		4 / 4TYR A 645
LEU A 677
LEU A 678
HIS A 714
None
1.44A20.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X7H_B_PFNB1374_1
(ZINC-BINDING ALCOHOL
DEHYDROGENASE
DOMAIN-CONTAINING
PROTEIN 2)		4um8 INTEGRIN BETA-6
(Homo
sapiens)		4 / 4TYR B 119
LEU B 155
LEU B 199
HIS B 195
None
1.34A19.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X7H_B_PFNB1374_1
(ZINC-BINDING ALCOHOL
DEHYDROGENASE
DOMAIN-CONTAINING
PROTEIN 2)		5hcc COMPLEMENT C5
(Homo
sapiens)		4 / 4TYR A1024
LEU A 983
LEU A 982
HIS A1030
None
1.45A17.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X7H_B_PFNB1374_1
(ZINC-BINDING ALCOHOL
DEHYDROGENASE
DOMAIN-CONTAINING
PROTEIN 2)		5nem INTEGRIN BETA-6
(Homo
sapiens)		4 / 4TYR B 116
LEU B 115
LEU B 196
HIS B 192
None
1.42A23.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X7H_B_PFNB1374_1
(ZINC-BINDING ALCOHOL
DEHYDROGENASE
DOMAIN-CONTAINING
PROTEIN 2)		5nem INTEGRIN BETA-6
(Homo
sapiens)		4 / 4TYR B 116
LEU B 152
LEU B 196
HIS B 192
None
1.22A23.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X7H_B_PFNB1374_1
(ZINC-BINDING ALCOHOL
DEHYDROGENASE
DOMAIN-CONTAINING
PROTEIN 2)		5tvt MATERNAL EMBRYONIC
LEUCINE ZIPPER
KINASE
(Homo
sapiens)		4 / 4TYR A  11
LEU A   8
LEU A   7
HIS A  74
None
0.90A23.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X7H_B_PFNB1374_1
(ZINC-BINDING ALCOHOL
DEHYDROGENASE
DOMAIN-CONTAINING
PROTEIN 2)		5y4e ANKYRIN-2,ANKYRIN-2
(Homo
sapiens)		4 / 4TYR A 886
LEU A1396
LEU A1366
HIS A1374
None
None
None
SO4  A1508 (-4.6A)
1.46A22.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NED_A_PFNA709_1
(LACTOTRANSFERRIN)		1bix AP ENDONUCLEASE 1
(Homo
sapiens)		4 / 6ASP A 219
ASP A 251
SER A 298
ALA A 263
None
1.18A22.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NED_A_PFNA709_1
(LACTOTRANSFERRIN)		1jmy BILE-SALT-ACTIVATED
LIPASE
(Homo
sapiens)		4 / 6VAL A 145
SER A 199
ALA A 170
PHE A  35
None
1.21A22.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NED_A_PFNA709_1
(LACTOTRANSFERRIN)		1xjl ANNEXIN A2
(Homo
sapiens)		4 / 6VAL A 298
ASP A 299
SER A 134
ALA A 271
None
1.17A24.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NED_A_PFNA709_1
(LACTOTRANSFERRIN)		3ctz XAA-PRO
AMINOPEPTIDASE 1
(Homo
sapiens)		4 / 6ASP A 120
VAL A 151
ASP A 152
ALA A  37
None
1.14A20.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NED_A_PFNA709_1
(LACTOTRANSFERRIN)		3dh1 TRNA-SPECIFIC
ADENOSINE DEAMINASE
2
(Homo
sapiens)		4 / 6VAL A 104
SER A 136
ALA A 141
PHE A 152
None
1.09A18.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NED_A_PFNA709_1
(LACTOTRANSFERRIN)		3odw RHO GUANINE
NUCLEOTIDE EXCHANGE
FACTOR 1
(Homo
sapiens)		4 / 6VAL A 649
SER A 761
ALA A 713
PHE A 729
None
1.07A20.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NED_A_PFNA709_1
(LACTOTRANSFERRIN)		3odx RHO GUANINE
NUCLEOTIDE EXCHANGE
FACTOR 1
(Homo
sapiens)		4 / 6VAL A 649
SER A 761
ALA A 713
PHE A 729
None
1.06A23.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NED_A_PFNA709_1
(LACTOTRANSFERRIN)		4fp8 ANTIBODY C05, HEAVY
CHAIN
(Homo
sapiens)		4 / 6ASP H 100
ASP H 101
SER H  27
ALA H  33
None
1.17A21.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NED_A_PFNA709_1
(LACTOTRANSFERRIN)		4q6r SPHINGOSINE-1-PHOSPH
ATE LYASE 1
(Homo
sapiens)		4 / 6ASP A 315
ASP A 350
ALA A 244
PHE A 245
LLP  A 353 ( 2.9A)
LLP  A 353 ( 3.8A)
None
None
1.12A20.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NED_A_PFNA709_1
(LACTOTRANSFERRIN)		4ric FANCONI-ASSOCIATED
NUCLEASE 1
(Homo
sapiens)		4 / 6ASP A 560
VAL A 574
ALA A 865
PHE A 866
None
1.09A21.34