POTENTIAL TARGETS FROM HUMAN (RESULTS FROM SUB-STRUCTURAL SIMILARITY SEARCHES)1) User may click on the DrReposER ID (the second column) to get information on the binding sites and drug molecule.
2) Click View (the second last column) to view matched residues and superposition in the NGL viewer (upper right part).
3) User may also click on the Dock (the last column) to get script for molecular docking in UCSF Chimera through AutoDock Vina.

	DrReposER ID / Desc.	Hit PDBID	Hit Macromolecule	Res. Matches	Interface	HETATM	RMSD	Seq. Identity (%)	View	Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4MA7_A_P2ZA301_1 (MAJOR PRION PROTEIN)	1adq	IGM-LAMBDA RF-AN FAB (HEAVY CHAIN) (Homo sapiens)	4 / 8	LEU H  80 TYR H  90 ILE H 107 VAL H  12	None	0.74A	17.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4MA7_A_P2ZA301_1 (MAJOR PRION PROTEIN)	1he3	BILIVERDIN IX BETA REDUCTASE (Homo sapiens)	4 / 8	LEU A  75 ILE A  72 VAL A  65 THR A  64	NAP  A1206 (-4.6A) None None None	0.93A	15.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4MA7_A_P2ZA301_1 (MAJOR PRION PROTEIN)	1hlg	LIPASE, GASTRIC (Homo sapiens)	4 / 8	VAL A  94 LEU A  63 ILE A 357 VAL A 366	None	0.96A	14.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4MA7_A_P2ZA301_1 (MAJOR PRION PROTEIN)	1ij9	VASCULAR CELL ADHESION PROTEIN 1 (Homo sapiens)	5 / 8	VAL A 195 LEU A 193 ILE A  97 VAL A 156 THR A 157	None	1.33A	17.35
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	4MA7_A_P2ZA301_1 (MAJOR PRION PROTEIN)	1qlz	PRION PROTEIN (Homo sapiens)	5 / 8	TYR A 128 TYR A 162 ILE A 182 VAL A 189 THR A 190	None	1.14A	88.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4MA7_A_P2ZA301_1 (MAJOR PRION PROTEIN)	1u71	DIHYDROFOLATE REDUCTASE (Homo sapiens)	4 / 8	LEU A 153 TYR A 156 TYR A 182 VAL A  10	None	0.89A	16.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4MA7_A_P2ZA301_1 (MAJOR PRION PROTEIN)	1wh6	HOMEOBOX PROTEIN CUX-2 (Homo sapiens)	4 / 8	VAL A  26 LEU A  30 ILE A  39 VAL A  88	None	0.98A	23.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4MA7_A_P2ZA301_1 (MAJOR PRION PROTEIN)	2anr	NEURO-ONCOLOGICAL VENTRAL ANTIGEN 1 (Homo sapiens)	4 / 8	VAL A  10 LEU A   8 ILE A  62 THR A  35	None	0.91A	19.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4MA7_A_P2ZA301_1 (MAJOR PRION PROTEIN)	2q8h	[PYRUVATE DEHYDROGENASE [LIPOAMIDE]] KINASE ISOZYME 1 (Homo sapiens)	4 / 8	VAL A 177 LEU A 181 TYR A 357 ILE A 361	None	0.94A	11.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4MA7_A_P2ZA301_1 (MAJOR PRION PROTEIN)	2v5n	CATION-INDEPENDENT MANNOSE-6-PHOSPHATE RECEPTOR (Homo sapiens)	4 / 8	VAL A1786 LEU A1761 TYR A1741 ILE A1732	None	0.95A	13.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4MA7_A_P2ZA301_1 (MAJOR PRION PROTEIN)	3cav	3-OXO-5-BETA-STEROID 4-DEHYDROGENASE (Homo sapiens)	5 / 8	VAL A 108 LEU A 109 TYR A  84 ILE A  82 THR A  25	None	1.37A	15.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4MA7_A_P2ZA301_1 (MAJOR PRION PROTEIN)	3crd	RAIDD (Homo sapiens)	4 / 8	VAL A   8 LEU A   9 ILE A  60 VAL A  26	None	0.93A	17.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4MA7_A_P2ZA301_1 (MAJOR PRION PROTEIN)	3ep7	S-ADENOSYLMETHIONINE DECARBOXYLASE ALPHA CHAIN (Homo sapiens)	4 / 8	VAL A 286 LEU A 284 ILE A 268 GLN A 300	None	0.86A	18.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4MA7_A_P2ZA301_1 (MAJOR PRION PROTEIN)	3ep7	S-ADENOSYLMETHIONINE DECARBOXYLASE ALPHA CHAIN (Homo sapiens)	4 / 8	VAL A 286 LEU A 284 TYR A 264 ILE A 268	None	0.92A	18.25