POTENTIAL TARGETS FROM HUMAN (RESULTS FROM SUB-STRUCTURAL SIMILARITY SEARCHES)
1) User may click on the DrReposER ID (the second column) to get information on the binding sites and drug molecule.
2) Click View (the second last column) to view matched residues and superposition in the NGL viewer (upper right part).
3) User may also click on the Dock (the last column) to get script for molecular docking in UCSF Chimera through AutoDock Vina.


DrReposER ID / Desc. Hit
PDBID
Hit
Macromolecule
Res.
Matches
Interface HETATM RMSD Seq.
Identity (%)
View Dock
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2BXC_A_P1ZA2001_1
(SERUM ALBUMIN)
1tf0 SERUM ALBUMIN
(Homo
sapiens)
5 / 12TYR A 150
SER A 192
GLN A 196
HIS A 242
ALA A 258
DKA  A1003 (-4.4A)
None
None
DKA  A1003 (-3.7A)
None
0.91A100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2BXC_A_P1ZA2001_1
(SERUM ALBUMIN)
1tf0 SERUM ALBUMIN
(Homo
sapiens)
12 / 12TYR A 150
SER A 192
GLN A 196
LYS A 199
LEU A 219
LEU A 238
HIS A 242
ARG A 257
ALA A 261
ILE A 264
ILE A 290
ALA A 291
DKA  A1003 (-4.4A)
None
None
CIT  A2001 ( 2.7A)
None
DKA  A1003 (-4.3A)
DKA  A1003 (-3.7A)
DKA  A1003 (-4.1A)
None
None
DKA  A1003 ( 4.5A)
CIT  A2001 ( 3.9A)
0.45A100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BXC_A_P1ZA2001_1
(SERUM ALBUMIN)
2qkc SUPEROXIDE DISMUTASE
[MN]
(Homo
sapiens)
6 / 12SER A 121
GLN A 143
LEU A  81
HIS A  74
ILE A  22
ALA A 164
None
MN  A 199 ( 4.9A)
None
MN  A 199 (-3.3A)
None
MN  A 199 ( 4.9A)
1.15A15.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BXC_A_P1ZA2001_1
(SERUM ALBUMIN)
2vcy TRANS-2-ENOYL-COA
REDUCTASE
(Homo
sapiens)
5 / 12LEU A 261
LEU A 175
ALA A 205
ILE A 201
ALA A 199
None
1.08A19.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BXC_A_P1ZA2001_1
(SERUM ALBUMIN)
2xa7 AP-2 COMPLEX SUBUNIT
BETA
(Homo
sapiens)
5 / 12LEU B 436
LEU B 465
ILE B 451
ILE B 429
ALA B 430
None
1.04A23.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BXC_A_P1ZA2001_1
(SERUM ALBUMIN)
4bvx EUKARYOTIC
TRANSLATION
ELONGATION FACTOR 1
EPSILON-1
(Homo
sapiens)
5 / 12TYR B  59
SER B  63
LEU B  10
LEU B  14
ILE B 155
None
1.03A15.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BXC_A_P1ZA2001_1
(SERUM ALBUMIN)
4d4z DEOXYHYPUSINE
HYDROXYLASE
(Homo
sapiens)
5 / 12LEU A 107
ALA A  70
ILE A  71
ILE A  98
ALA A  97
None
0.84A20.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BXC_A_P1ZA2001_1
(SERUM ALBUMIN)
4ric FANCONI-ASSOCIATED
NUCLEASE 1
(Homo
sapiens)
5 / 12GLN A 533
LEU A 421
LEU A 434
ALA A 440
ILE A 439
None
1.00A22.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BXC_A_P1ZA2001_1
(SERUM ALBUMIN)
5c5x AQUAPORIN-5
(Homo
sapiens)
5 / 12SER A 189
HIS A 173
ALA A 143
ILE A 146
ILE A  72
None
0.84A17.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BXC_A_P1ZA2001_1
(SERUM ALBUMIN)
5k8d COAGULATION FACTOR
VIII
COAGULATION FACTOR
VIII,IG GAMMA-1
CHAIN C REGION
(Homo
sapiens)
5 / 12SER A 109
LEU A 164
LEU B2001
HIS B1957
ILE A 173
None
1.07A22.45
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2BXC_B_P1ZB2001_1
(SERUM ALBUMIN)
1tf0 SERUM ALBUMIN
(Homo
sapiens)
9 / 9TYR A 150
GLU A 153
LEU A 219
ARG A 222
LEU A 238
HIS A 242
ARG A 257
ALA A 261
ALA A 291
DKA  A1003 (-4.4A)
None
None
CIT  A2001 ( 2.9A)
DKA  A1003 (-4.3A)
DKA  A1003 (-3.7A)
DKA  A1003 (-4.1A)
None
CIT  A2001 ( 3.9A)
0.45A100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BXC_B_P1ZB2001_1
(SERUM ALBUMIN)
2nsm CARBOXYPEPTIDASE N
CATALYTIC CHAIN
(Homo
sapiens)
5 / 9GLU A 115
LEU A   1
ARG A   4
LEU A  77
ALA A  70
None
SO4  A 776 (-3.7A)
SO4  A 776 (-3.8A)
None
None
1.06A19.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BXC_B_P1ZB2001_1
(SERUM ALBUMIN)
2xn6 THYROXINE-BINDING
GLOBULIN
(Homo
sapiens)
5 / 9GLU A  71
LEU A 350
LEU A  57
ALA A  64
ALA A 308
None
1.17A19.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BXC_B_P1ZB2001_1
(SERUM ALBUMIN)
3mpx FYVE, RHOGEF AND PH
DOMAIN-CONTAINING
PROTEIN 5
(Homo
sapiens)
5 / 9TYR A1046
LEU A 967
LEU A 963
ARG A1042
ALA A 906
None
1.23A23.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BXC_B_P1ZB2001_1
(SERUM ALBUMIN)
3nks PROTOPORPHYRINOGEN
OXIDASE
(Homo
sapiens)
5 / 9GLU A 461
LEU A 236
LEU A  74
HIS A  20
ALA A  69
None
1.40A22.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BXC_B_P1ZB2001_1
(SERUM ALBUMIN)
3op0 SIGNAL TRANSDUCTION
PROTEIN CBL-C
(Homo
sapiens)
5 / 9GLU A  13
LEU A  55
LEU A  80
ALA A  85
ALA A  17
None
1.36A18.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BXC_B_P1ZB2001_1
(SERUM ALBUMIN)
3x1o ROQUIN-1
(Homo
sapiens)
5 / 9GLU A 293
LEU A 179
LEU A 183
ARG A 190
ALA A 294
None
1.50A16.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BXC_B_P1ZB2001_1
(SERUM ALBUMIN)
4c6o CAD PROTEIN
(Homo
sapiens)
5 / 9GLU A1592
LEU A1650
LEU A1664
HIS A1642
ARG A1617
None
1.48A20.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BXC_B_P1ZB2001_1
(SERUM ALBUMIN)
4o9r SMOOTHENED
HOMOLOG/SOLUBLE
CYTOCHROME B562
CHIMERIC PROTEIN
(Escherichia
coli;
Homo
sapiens)
5 / 9GLU A1018
LEU A1068
LEU A1010
ALA A1029
ALA A1091
None
1.33A21.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BXC_B_P1ZB2001_1
(SERUM ALBUMIN)
4on3 SORTING NEXIN-10
(Homo
sapiens)
5 / 9GLU A   9
LEU A 121
LEU A 106
ALA A 109
ALA A  42
None
NA  A 315 (-4.5A)
None
None
None
1.19A15.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BXP_A_P1ZA3001_1
(SERUM ALBUMIN)
1md7 C1R COMPLEMENT
SERINE PROTEASE
(Homo
sapiens)
5 / 12LEU A 561
LEU A 475
LEU A 543
ALA A 542
ILE A 541
None
1.21A20.14
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2BXP_A_P1ZA3001_1
(SERUM ALBUMIN)
1tf0 SERUM ALBUMIN
(Homo
sapiens)
10 / 12PHE A 211
TRP A 214
LEU A 219
PHE A 223
LEU A 238
HIS A 242
LEU A 260
ALA A 261
ILE A 264
ALA A 291
None
None
None
None
DKA  A1003 (-4.3A)
DKA  A1003 (-3.7A)
None
None
None
CIT  A2001 ( 3.9A)
0.44A100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2BXP_A_P1ZA3001_1
(SERUM ALBUMIN)
1tf0 SERUM ALBUMIN
(Homo
sapiens)
9 / 12PHE A 211
TRP A 214
LEU A 219
PHE A 223
LEU A 238
HIS A 242
LEU A 260
SER A 287
ALA A 291
None
None
None
None
DKA  A1003 (-4.3A)
DKA  A1003 (-3.7A)
None
None
CIT  A2001 ( 3.9A)
0.62A100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BXP_A_P1ZA3001_1
(SERUM ALBUMIN)
2v0s LR1
(Homo
sapiens)
5 / 12LEU A  77
LEU A  54
LEU A  18
ILE A  15
ALA A  28
None
1.21A17.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BXP_A_P1ZA3001_1
(SERUM ALBUMIN)
2xdv MYC-INDUCED NUCLEAR
ANTIGEN
(Homo
sapiens)
5 / 12LEU A 198
PHE A 234
LEU A 226
ILE A 187
ALA A 242
None
None
None
None
OGA  A 601 ( 4.2A)
1.18A22.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BXP_A_P1ZA3001_1
(SERUM ALBUMIN)
2ybu ACIDIC MAMMALIAN
CHITINASE
(Homo
sapiens)
5 / 12PHE A 119
LEU A 127
LEU A  94
ALA A  95
ILE A  96
None
1.12A20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BXP_A_P1ZA3001_1
(SERUM ALBUMIN)
2ygs APOPTOTIC PROTEASE
ACTIVATING FACTOR 1
(Homo
sapiens)
5 / 12LEU A  87
LEU A  75
ALA A  53
ILE A  57
ALA A  15
None
1.17A8.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BXP_A_P1ZA3001_1
(SERUM ALBUMIN)
3bpt 3-HYDROXYISOBUTYRYL-
COA HYDROLASE
(Homo
sapiens)
5 / 12PHE A 117
LEU A 124
LEU A  60
LEU A  51
ILE A  49
None
1.21A19.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BXP_A_P1ZA3001_1
(SERUM ALBUMIN)
3gxu EPHRIN TYPE-A
RECEPTOR 4
(Homo
sapiens)
5 / 12PHE A 153
LEU A  96
PHE A  94
LEU A 155
SER A 168
None
1.21A14.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BXP_A_P1ZA3001_1
(SERUM ALBUMIN)
3mos TRANSKETOLASE
(Homo
sapiens)
5 / 12TRP A 211
PHE A 228
LEU A 182
ALA A  44
ILE A  47
None
1.13A22.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BXP_A_P1ZA3001_1
(SERUM ALBUMIN)
3tac LIPRIN-ALPHA-2
(Homo
sapiens)
5 / 12LEU B1063
LEU B1054
LEU B1051
ALA B1048
ILE B1024
None
1.24A18.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BXP_A_P1ZA3001_1
(SERUM ALBUMIN)
3tad LIPRIN-ALPHA-2
(Homo
sapiens)
5 / 12LEU A1063
LEU A1054
LEU A1051
ALA A1048
ILE A1024
None
1.25A18.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BXP_A_P1ZA3001_1
(SERUM ALBUMIN)
3u12 USP37 PROTEIN
(Homo
sapiens)
5 / 12LEU A  38
LEU A  74
LEU A  72
ALA A  92
ILE A   6
None
None
None
None
UNX  A1019 ( 4.3A)
1.09A11.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BXQ_A_P1ZA2002_1
(SERUM ALBUMIN)
1jmy BILE-SALT-ACTIVATED
LIPASE
(Homo
sapiens)
5 / 12LEU A   3
LEU A  98
ILE A 137
ILE A 178
ALA A 179
None
0.85A22.81
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2BXQ_A_P1ZA2002_1
(SERUM ALBUMIN)
1tf0 SERUM ALBUMIN
(Homo
sapiens)
6 / 12LEU A 219
ARG A 222
PHE A 223
LEU A 238
HIS A 242
ILE A 264
None
CIT  A2001 ( 2.9A)
None
DKA  A1003 (-4.3A)
DKA  A1003 (-3.7A)
None
1.45A99.83
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2BXQ_A_P1ZA2002_1
(SERUM ALBUMIN)
1tf0 SERUM ALBUMIN
(Homo
sapiens)
10 / 12LYS A 199
LEU A 219
ARG A 222
PHE A 223
LEU A 238
HIS A 242
ILE A 264
SER A 287
ILE A 290
ALA A 291
CIT  A2001 ( 2.7A)
None
CIT  A2001 ( 2.9A)
None
DKA  A1003 (-4.3A)
DKA  A1003 (-3.7A)
None
None
DKA  A1003 ( 4.5A)
CIT  A2001 ( 3.9A)
0.82A99.83
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2BXQ_A_P1ZA2002_1
(SERUM ALBUMIN)
1tf0 SERUM ALBUMIN
(Homo
sapiens)
11 / 12LYS A 199
LEU A 219
PHE A 223
LEU A 238
HIS A 242
ARG A 257
LEU A 260
ILE A 264
SER A 287
ILE A 290
ALA A 291
CIT  A2001 ( 2.7A)
None
None
DKA  A1003 (-4.3A)
DKA  A1003 (-3.7A)
DKA  A1003 (-4.1A)
None
None
None
DKA  A1003 ( 4.5A)
CIT  A2001 ( 3.9A)
0.83A99.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BXQ_A_P1ZA2002_1
(SERUM ALBUMIN)
2a9j BISPHOSPHOGLYCERATE
MUTASE
(Homo
sapiens)
5 / 12LEU A 199
LEU A 195
ILE A 185
ILE A 173
ALA A 174
None
0.99A18.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BXQ_A_P1ZA2002_1
(SERUM ALBUMIN)
2dh3 4F2 CELL-SURFACE
ANTIGEN HEAVY CHAIN
(Homo
sapiens)
5 / 12LEU A 192
PHE A 189
LEU A 143
LEU A 129
ILE A 163
None
0.87A22.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BXQ_A_P1ZA2002_1
(SERUM ALBUMIN)
2xa7 AP-2 COMPLEX SUBUNIT
BETA
(Homo
sapiens)
5 / 12LEU B 436
LEU B 465
ILE B 451
ILE B 429
ALA B 430
None
0.97A23.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BXQ_A_P1ZA2002_1
(SERUM ALBUMIN)
2z63 TOLL-LIKE RECEPTOR
4, VARIABLE
LYMPHOCYTE RECEPTOR
B
(Eptatretus
burgeri;
Homo
sapiens)
5 / 12LEU A  83
LEU A  85
LEU A  66
ILE A  48
ALA A  97
None
1.01A21.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BXQ_A_P1ZA2002_1
(SERUM ALBUMIN)
2z7x TOLL-LIKE RECEPTOR
1, VARIABLE
LYMPHOCYTE RECEPTOR
B
(Eptatretus
burgeri;
Homo
sapiens)
6 / 12LEU B 400
LEU B 425
LEU B 428
ILE B 405
ILE B 390
ALA B 391
None
1.46A23.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BXQ_A_P1ZA2002_1
(SERUM ALBUMIN)
3p8c NCK-ASSOCIATED
PROTEIN 1
(Homo
sapiens)
5 / 12LEU B 999
LEU B1043
ILE B 910
SER B 860
ALA B 864
None
1.04A20.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BXQ_A_P1ZA2002_1
(SERUM ALBUMIN)
4ay1 CHITINASE-3-LIKE
PROTEIN 2
(Homo
sapiens)
6 / 12LEU A 158
PHE A 111
LEU A 162
LEU A 140
ILE A 101
ALA A 182
None
1.44A20.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BXQ_A_P1ZA2002_1
(SERUM ALBUMIN)
4pj6 LEUCYL-CYSTINYL
AMINOPEPTIDASE
(Homo
sapiens)
5 / 12LEU A1025
PHE A 750
LEU A 787
LEU A 779
ILE A 775
None
1.02A21.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BXQ_A_P1ZA2002_1
(SERUM ALBUMIN)
5c7m E3 UBIQUITIN-PROTEIN
LIGASE ITCHY HOMOLOG
(Homo
sapiens)
6 / 12LEU A 886
PHE A 815
LEU A 877
LEU A 875
ILE A 894
ALA A 893
None
1.45A22.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BXQ_A_P1ZA2002_1
(SERUM ALBUMIN)
5ed1 DOUBLE-STRANDED
RNA-SPECIFIC EDITASE
1
(Homo
sapiens)
5 / 12LEU A 556
ILE A 545
SER A 517
ILE A 520
ALA A 521
None
0.96A20.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BXQ_A_P1ZA2002_1
(SERUM ALBUMIN)
5hdh TOLL-LIKE RECEPTOR 8
(Homo
sapiens)
5 / 12LEU A 413
PHE A 417
LEU A 382
LEU A 401
ILE A 399
None
1.00A21.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BXQ_A_P1ZA2002_1
(SERUM ALBUMIN)
5vil MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE KINASE 5
(Homo
sapiens)
6 / 12LEU A 938
PHE A 937
LEU A 788
LEU A 867
ILE A 871
ILE A 915
None
1.32A8.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BXQ_A_P1ZA2002_1
(SERUM ALBUMIN)
6eti ATP-BINDING CASSETTE
SUB-FAMILY G MEMBER
2
(Homo
sapiens)
5 / 12LEU A  75
PHE A 253
LEU A 228
ILE A 249
ILE A 242
None
0.95A8.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BXQ_A_P1ZA2002_1
(SERUM ALBUMIN)
6ez8 HUNTINGTIN
(Homo
sapiens)
5 / 12LEU A1614
LEU A1630
LEU A1581
ILE A1575
ILE A1606
None
1.04A6.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2W98_A_P1ZA1351_1
(PROSTAGLANDIN
REDUCTASE 2)
1tff UBIQUITIN
THIOLESTERASE
PROTEIN OTUB2
(Homo
sapiens)
5 / 10TYR A  60
PHE A 102
LEU A  64
VAL A 109
LEU A  61
None
1.27A22.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2W98_A_P1ZA1351_1
(PROSTAGLANDIN
REDUCTASE 2)
1uch UBIQUITIN C-TERMINAL
HYDROLASE UCH-L3
(Homo
sapiens)
5 / 10ILE A 101
TYR A 137
TYR A 141
LEU A  23
LEU A  25
None
1.50A22.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2W98_A_P1ZA1351_1
(PROSTAGLANDIN
REDUCTASE 2)
2q9v MEMBRANE-ASSOCIATED
GUANYLATE KINASE, WW
AND PDZ
DOMAIN-CONTAINING
PROTEIN 1
(Homo
sapiens)
5 / 10ILE A 870
MET A 908
LEU A 844
VAL A 917
LEU A 919
None
1.26A14.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2W98_A_P1ZA1351_1
(PROSTAGLANDIN
REDUCTASE 2)
2w5h SERINE/THREONINE-PRO
TEIN KINASE NEK2
(Homo
sapiens)
5 / 10ILE A  98
PHE A 112
TYR A 182
VAL A 155
LEU A 149
None
1.45A21.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2W98_A_P1ZA1351_1
(PROSTAGLANDIN
REDUCTASE 2)
2z65 TOLL-LIKE RECEPTOR
4, VARIABLE
LYMPHOCYTE RECEPTOR
B
(Eptatretus
burgeri;
Homo
sapiens)
5 / 10ILE A  93
PHE A 144
LEU A 107
VAL A 132
LEU A 131
None
1.44A22.35
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2W98_A_P1ZA1351_1
(PROSTAGLANDIN
REDUCTASE 2)
2zb4 PROSTAGLANDIN
REDUCTASE 2
(Homo
sapiens)
7 / 10TYR A  51
ILE A  65
TYR A 259
TYR A 265
LEU A 288
VAL A 289
LEU A 290
5OP  A 600 (-3.4A)
5OP  A 600 ( 4.6A)
NAP  A 500 (-4.4A)
None
NAP  A 500 (-4.7A)
NAP  A 500 ( 3.6A)
5OP  A 600 (-3.7A)
0.87A97.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2W98_A_P1ZA1351_1
(PROSTAGLANDIN
REDUCTASE 2)
3bcz PROTEIN MEMO1
(Homo
sapiens)
5 / 10ILE A 154
PHE A 173
TYR A  96
VAL A 158
LEU A  77
None
1.41A20.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2W98_A_P1ZA1351_1
(PROSTAGLANDIN
REDUCTASE 2)
3fxi TOLL-LIKE RECEPTOR 4
(Homo
sapiens)
5 / 10ILE A  93
PHE A 144
LEU A 107
VAL A 132
LEU A 131
None
1.40A20.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2W98_A_P1ZA1351_1
(PROSTAGLANDIN
REDUCTASE 2)
3l6a EUKARYOTIC
TRANSLATION
INITIATION FACTOR 4
GAMMA 2
(Homo
sapiens)
5 / 10ILE A 114
PHE A 137
MET A 164
LEU A 153
LEU A 141
None
1.12A21.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2W98_A_P1ZA1351_1
(PROSTAGLANDIN
REDUCTASE 2)
3se4 INTERFERON OMEGA-1
(Homo
sapiens)
5 / 10ILE B 150
PHE B  40
MET B  44
VAL B  58
LEU B 122
None
1.37A19.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2W98_A_P1ZA1351_1
(PROSTAGLANDIN
REDUCTASE 2)
4dou ADIPONECTIN
(Homo
sapiens)
5 / 10PHE A 273
TYR A 159
TYR A 300
LEU A 316
LEU A 354
None
1.40A20.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2W98_A_P1ZA1351_1
(PROSTAGLANDIN
REDUCTASE 2)
6bbp CYTOHESIN-3,ADP-RIBO
SYLATION FACTOR 6
(Homo
sapiens;
Mus
musculus)
5 / 10ILE A 225
PHE A 218
LEU A 145
VAL A 146
LEU A 239
None
1.35A12.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2W98_A_P1ZA1351_1
(PROSTAGLANDIN
REDUCTASE 2)
6cd8 GLUCOSE-INDUCED
DEGRADATION PROTEIN
4 HOMOLOG
(Homo
sapiens)
5 / 10ILE A 260
PHE A 128
LEU A 155
VAL A 148
LEU A 145
None
None
None
UNX  A 303 ( 4.6A)
None
1.42A13.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2W98_A_P1ZA1352_1
(PROSTAGLANDIN
REDUCTASE 2)
2bfe 2-OXOISOVALERATE
DEHYDROGENASE ALPHA
SUBUNIT
(Homo
sapiens)
4 / 7TYR A 121
TYR A 190
LEU A 103
ASN A 105
None
1.19A22.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2W98_A_P1ZA1352_1
(PROSTAGLANDIN
REDUCTASE 2)
4fzd SERINE/THREONINE-PRO
TEIN KINASE MST4
(Homo
sapiens)
4 / 7TYR B 101
LEU B 102
LYS B 159
TYR B  86
GOL  B1000 (-4.0A)
GOL  B1000 (-4.7A)
None
None
1.42A21.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2W98_A_P1ZA1352_1
(PROSTAGLANDIN
REDUCTASE 2)
4n49 CAP-SPECIFIC MRNA
(NUCLEOSIDE-2'-O-)-M
ETHYLTRANSFERASE 1
(Homo
sapiens)
4 / 7LEU A 479
ASN A 478
TYR A 459
LYS A 381
None
1.45A20.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2W98_A_P1ZA1352_1
(PROSTAGLANDIN
REDUCTASE 2)
4red 5'-AMP-ACTIVATED
PROTEIN KINASE
CATALYTIC SUBUNIT
ALPHA-1
(Homo
sapiens)
4 / 7TYR A 238
TYR A 234
LEU A 239
ASN A 240
None
1.47A19.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2W98_A_P1ZA1352_1
(PROSTAGLANDIN
REDUCTASE 2)
4wjl INACTIVE DIPEPTIDYL
PEPTIDASE 10
(Homo
sapiens)
4 / 7TYR A 282
ASN A 760
TYR A 683
LYS A 650
None
1.42A20.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2W98_A_P1ZA1352_1
(PROSTAGLANDIN
REDUCTASE 2)
6dd3 CYTOSOLIC PURINE
5'-NUCLEOTIDASE
(Homo
sapiens)
4 / 7TYR A 262
TYR A  60
LEU A 263
TYR A 255
None
1.40A12.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2W98_A_P1ZA1353_1
(PROSTAGLANDIN
REDUCTASE 2)
1xap RETINOIC ACID
RECEPTOR BETA
(Homo
sapiens)
5 / 9PHE A 192
GLU A 190
GLY A 320
GLU A 182
ILE A 184
None
1.34A21.31
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2W98_A_P1ZA1353_1
(PROSTAGLANDIN
REDUCTASE 2)
2zb4 PROSTAGLANDIN
REDUCTASE 2
(Homo
sapiens)
5 / 9THR A  97
GLU A 115
VAL A 117
GLY A 134
ILE A 300
None
0.61A97.49
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2W98_A_P1ZA1353_1
(PROSTAGLANDIN
REDUCTASE 2)
2zb4 PROSTAGLANDIN
REDUCTASE 2
(Homo
sapiens)
5 / 9THR A  97
VAL A 117
GLY A 134
PHE A 296
ILE A 300
None
0.73A97.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2W98_A_P1ZA1353_1
(PROSTAGLANDIN
REDUCTASE 2)
3k9m CATHEPSIN B
(Homo
sapiens)
5 / 9PHE A 174
GLU A 245
VAL A 247
GLY A  33
GLU A  78
None
1.49A21.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2W98_A_P1ZA1353_1
(PROSTAGLANDIN
REDUCTASE 2)
4amt RENIN
(Homo
sapiens)
5 / 9GLU A 156
VAL A 131
GLY A 152
PHE A 134
GLU A 121
None
1.39A23.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2W98_B_P1ZB1356_1
(PROSTAGLANDIN
REDUCTASE 2)
1i4e CASPASE-8
(Homo
sapiens)
4 / 8ILE B2311
PHE B2476
LEU B2425
LEU B2429
None
0.73A20.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2W98_B_P1ZB1356_1
(PROSTAGLANDIN
REDUCTASE 2)
1je6 MHC CLASS I
CHAIN-RELATED
PROTEIN
(Homo
sapiens)
4 / 8PHE A 117
TYR A 157
LEU A  73
LEU A  90
None
0.87A22.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2W98_B_P1ZB1356_1
(PROSTAGLANDIN
REDUCTASE 2)
1m9i ANNEXIN VI
(Homo
sapiens)
4 / 8ILE A 461
TYR A 477
LEU A 489
LEU A 501
None
0.90A21.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2W98_B_P1ZB1356_1
(PROSTAGLANDIN
REDUCTASE 2)
2bzl TYROSINE-PROTEIN
PHOSPHATASE,
NON-RECEPTOR TYPE 14
(Homo
sapiens)
4 / 8TYR A 913
ILE A 916
LEU A1133
VAL A1130
None
0.89A21.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2W98_B_P1ZB1356_1
(PROSTAGLANDIN
REDUCTASE 2)
2gf1 INSULIN-LIKE GROWTH
FACTOR I
(Homo
sapiens)
4 / 8TYR A  31
LEU A  14
VAL A  11
LEU A  10
None
0.88A13.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2W98_B_P1ZB1356_1
(PROSTAGLANDIN
REDUCTASE 2)
2y9t TUMOR PROTEIN 63
(Homo
sapiens)
4 / 8ILE A 601
PHE A 565
LEU A 556
LEU A 553
None
0.90A11.83
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2W98_B_P1ZB1356_1
(PROSTAGLANDIN
REDUCTASE 2)
2zb4 PROSTAGLANDIN
REDUCTASE 2
(Homo
sapiens)
5 / 8TYR A  51
ILE A  65
TYR A 259
TYR A 265
LEU A 288
5OP  A 600 (-3.4A)
5OP  A 600 ( 4.6A)
NAP  A 500 (-4.4A)
None
NAP  A 500 (-4.7A)
0.61A97.49
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2W98_B_P1ZB1356_1
(PROSTAGLANDIN
REDUCTASE 2)
2zb4 PROSTAGLANDIN
REDUCTASE 2
(Homo
sapiens)
6 / 8TYR A  51
TYR A 259
TYR A 265
LEU A 288
VAL A 289
LEU A 290
5OP  A 600 (-3.4A)
NAP  A 500 (-4.4A)
None
NAP  A 500 (-4.7A)
NAP  A 500 ( 3.6A)
5OP  A 600 (-3.7A)
0.52A97.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2W98_B_P1ZB1356_1
(PROSTAGLANDIN
REDUCTASE 2)
3naf CALCIUM-ACTIVATED
POTASSIUM CHANNEL
SUBUNIT
ALPHA-1,CALCIUM-ACTI
VATED POTASSIUM
CHANNEL SUBUNIT
ALPHA-1,CALCIUM-ACTI
VATED POTASSIUM
CHANNEL SUBUNIT
ALPHA-1
(Homo
sapiens)
4 / 8ILE A 598
TYR A 996
LEU A1052
VAL A 977
None
0.88A18.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2W98_B_P1ZB1356_1
(PROSTAGLANDIN
REDUCTASE 2)
3nmz APC VARIANT PROTEIN
(Homo
sapiens)
4 / 8ILE A 357
LEU A 407
VAL A 406
LEU A 410
None
0.82A21.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2W98_B_P1ZB1356_1
(PROSTAGLANDIN
REDUCTASE 2)
3vut DUAL SPECIFICITY
MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE 4
(Homo
sapiens)
4 / 8ILE A 367
TYR A 358
LEU A 293
LEU A 297
None
0.88A21.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2W98_B_P1ZB1356_1
(PROSTAGLANDIN
REDUCTASE 2)
4mk0 BETA-ADRENERGIC
RECEPTOR KINASE 1
(Homo
sapiens)
4 / 8TYR A  86
ILE A 153
PHE A  59
TYR A 112
None
0.83A19.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2W98_B_P1ZB1356_1
(PROSTAGLANDIN
REDUCTASE 2)
4wk0 INTEGRIN BETA-1
(Homo
sapiens)
4 / 8ILE B 375
PHE B 111
LEU B 438
LEU B 101
None
0.63A23.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2W98_B_P1ZB1356_1
(PROSTAGLANDIN
REDUCTASE 2)
5d68 KREV INTERACTION
TRAPPED PROTEIN 1
(Homo
sapiens)
4 / 8PHE A 708
TYR A 683
VAL A 660
LEU A 669
None
0.80A21.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2W98_B_P1ZB1356_1
(PROSTAGLANDIN
REDUCTASE 2)
5i6v TYROSINE-PROTEIN
PHOSPHATASE
NON-RECEPTOR TYPE 11
(Homo
sapiens)
4 / 8TYR A 515
ILE A 226
VAL A 471
LEU A 475
None
0.83A20.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2W98_B_P1ZB1357_1
(PROSTAGLANDIN
REDUCTASE 2)
1r47 ALPHA-GALACTOSIDASE
A
(Homo
sapiens)
4 / 6TYR A  86
LEU A 300
ASN A 298
ASP A 234
None
1.24A21.54
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2W98_B_P1ZB1357_1
(PROSTAGLANDIN
REDUCTASE 2)
2zb4 PROSTAGLANDIN
REDUCTASE 2
(Homo
sapiens)
4 / 6LEU A 288
ASN A 291
LYS A 293
ASP A 294
NAP  A 500 (-4.7A)
None
None
None
0.57A97.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2W98_B_P1ZB1357_1
(PROSTAGLANDIN
REDUCTASE 2)
3gv5 DNA POLYMERASE IOTA
(Homo
sapiens)
4 / 6LEU B 205
ASN B 202
LYS B  28
ASP B 131
None
1.39A22.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2W98_B_P1ZB1357_1
(PROSTAGLANDIN
REDUCTASE 2)
3rru TOM1L1 PROTEIN
(Homo
sapiens)
4 / 6TYR A 143
LEU A 120
ASN A 121
ASP A  77
None
1.38A18.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2W98_B_P1ZB1357_1
(PROSTAGLANDIN
REDUCTASE 2)
4i8v CYTOCHROME P450 1A1
(Homo
sapiens)
4 / 6TYR A 189
LEU A 215
ASN A 219
ASP A 320
None
None
None
BHF  A 602 (-3.7A)
1.26A21.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2W98_B_P1ZB1357_1
(PROSTAGLANDIN
REDUCTASE 2)
6cet GATOR COMPLEX
PROTEIN DEPDC5
(Homo
sapiens)
4 / 6LYS D 411
LEU D 271
ASN D 197
ASP D 189
None
1.45A11.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2W98_B_P1ZB1358_1
(PROSTAGLANDIN
REDUCTASE 2)
2a98 INOSITOL
1,4,5-TRISPHOSPHATE
3-KINASE C
(Homo
sapiens)
4 / 6ASP A 484
TYR A 595
PHE A 552
LEU A 581
None
1.04A20.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2W98_B_P1ZB1358_1
(PROSTAGLANDIN
REDUCTASE 2)
2vd5 DMPK PROTEIN
(Homo
sapiens)
4 / 6ASP A 204
TYR A 151
PHE A 354
LEU A 159
None
BI8  A1417 (-4.9A)
None
None
1.09A21.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2W98_B_P1ZB1358_1
(PROSTAGLANDIN
REDUCTASE 2)
2vsv RHOPHILIN-2
(Homo
sapiens)
4 / 6ASP A 556
TYR A 557
PHE A 519
LEU A 578
None
1.17A14.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2W98_B_P1ZB1358_1
(PROSTAGLANDIN
REDUCTASE 2)
2xrc HUMAN COMPLEMENT
FACTOR I
(Homo
sapiens)
4 / 6ASP A 411
TYR A 408
TYR A 486
TYR A 547
None
1.23A20.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2W98_B_P1ZB1358_1
(PROSTAGLANDIN
REDUCTASE 2)
3b3l KETOHEXOKINASE
(Homo
sapiens)
4 / 6ASP A 231
TYR A 212
PHE A 201
LEU A 211
None
1.15A21.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2W98_B_P1ZB1358_1
(PROSTAGLANDIN
REDUCTASE 2)
3pta DNA
(CYTOSINE-5)-METHYLT
RANSFERASE 1
(Homo
sapiens)
4 / 6ASP A 937
TYR A 940
TYR A 933
LEU A 941
None
1.19A16.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2W98_B_P1ZB1358_1
(PROSTAGLANDIN
REDUCTASE 2)
5fhz ALDEHYDE
DEHYDROGENASE FAMILY
1 MEMBER A3
(Homo
sapiens)
4 / 6TYR A 492
PHE A 144
TYR A 143
LEU A 494
None
1.23A21.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2W98_B_P1ZB1358_1
(PROSTAGLANDIN
REDUCTASE 2)
5tte E3 UBIQUITIN-PROTEIN
LIGASE ARIH1
(Homo
sapiens)
4 / 6TYR B 474
TYR B 481
TYR B 547
LEU B 482
None
1.14A19.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2W98_B_P1ZB1358_1
(PROSTAGLANDIN
REDUCTASE 2)
5udh E3 UBIQUITIN-PROTEIN
LIGASE ARIH1
(Homo
sapiens)
4 / 6TYR A 474
TYR A 481
TYR A 547
LEU A 482
None
1.20A20.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2W98_B_P1ZB1358_1
(PROSTAGLANDIN
REDUCTASE 2)
6dd3 CYTOSOLIC PURINE
5'-NUCLEOTIDASE
(Homo
sapiens)
4 / 6ASP A 351
TYR A  55
PHE A  51
LEU A 232
PO4  A 601 ( 4.6A)
None
None
None
1.23A12.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2W98_B_P1ZB1359_1
(PROSTAGLANDIN
REDUCTASE 2)
1a4i METHYLENETETRAHYDROF
OLATE DEHYDROGENASE
/
METHENYLTETRAHYDROFO
LATE CYCLOHYDROLASE
(Homo
sapiens)
4 / 6THR A 111
GLU A 112
MET A  82
ILE A 118
None
1.20A21.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2W98_B_P1ZB1359_1
(PROSTAGLANDIN
REDUCTASE 2)
1dgf CATALASE
(Homo
sapiens)
4 / 6THR A 434
GLU A 191
MET A 350
ILE A 159
None
None
HEM  A3000 (-3.7A)
None
1.42A19.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2W98_B_P1ZB1359_1
(PROSTAGLANDIN
REDUCTASE 2)
1di4 LYSOZYME C
(Homo
sapiens)
4 / 6THR A  11
GLU A   7
MET A  29
ILE A  56
None
0.99A18.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2W98_B_P1ZB1359_1
(PROSTAGLANDIN
REDUCTASE 2)
1fnf FIBRONECTIN
(Homo
sapiens)
4 / 6THR A1301
GLU A1302
MET A1252
PHE A1244
None
1.41A21.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2W98_B_P1ZB1359_1
(PROSTAGLANDIN
REDUCTASE 2)
1nvp TRANSCRIPTION
INITIATION FACTOR
IIA BETA CHAIN
(Homo
sapiens)
4 / 6MET C 358
LYS C 369
PHE C 367
ILE C 366
None
1.41A13.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2W98_B_P1ZB1359_1
(PROSTAGLANDIN
REDUCTASE 2)
2b4x ANTITHROMBIN-III
(Homo
sapiens)
4 / 6THR I 419
GLU I 414
PHE I 221
ILE I 219
None
1.37A21.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2W98_B_P1ZB1359_1
(PROSTAGLANDIN
REDUCTASE 2)
2h57 ADP-RIBOSYLATION
FACTOR-LIKE PROTEIN
6
(Homo
sapiens)
4 / 6THR A  31
GLU A  56
PHE A  53
ILE A  51
MG  A 202 ( 3.0A)
None
None
None
1.44A20.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2W98_B_P1ZB1359_1
(PROSTAGLANDIN
REDUCTASE 2)
2iip NICOTINAMIDE
N-METHYLTRANSFERASE
(Homo
sapiens)
4 / 6GLU A  76
LYS A  55
PHE A  78
ILE A  81
None
1.14A21.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2W98_B_P1ZB1359_1
(PROSTAGLANDIN
REDUCTASE 2)
2lkk FATTY ACID-BINDING
PROTEIN, LIVER
(Homo
sapiens)
4 / 6GLU A  13
MET A  19
PHE A 120
ILE A 118
None
OLA  A 128 (-3.5A)
OLA  A 128 ( 4.3A)
None
1.34A18.82
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2W98_B_P1ZB1359_1
(PROSTAGLANDIN
REDUCTASE 2)
2zb4 PROSTAGLANDIN
REDUCTASE 2
(Homo
sapiens)
5 / 6THR A  97
GLU A 115
LYS A 293
PHE A 296
ILE A 300
None
0.64A97.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2W98_B_P1ZB1359_1
(PROSTAGLANDIN
REDUCTASE 2)
3ba0 MACROPHAGE
METALLOELASTASE
(Homo
sapiens)
4 / 6THR A 292
GLU A 337
PHE A 345
ILE A 355
None
1.30A21.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2W98_B_P1ZB1359_1
(PROSTAGLANDIN
REDUCTASE 2)
3lms CARBOXYPEPTIDASE B2
(Homo
sapiens)
4 / 6GLU A 292
MET A 195
PHE A  78
ILE A  74
None
1.18A19.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2W98_B_P1ZB1359_1
(PROSTAGLANDIN
REDUCTASE 2)
3thz DNA MISMATCH REPAIR
PROTEIN MSH2
(Homo
sapiens)
4 / 6THR A 456
GLU A 452
PHE A 450
ILE A 584
None
1.27A17.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2W98_B_P1ZB1359_1
(PROSTAGLANDIN
REDUCTASE 2)
3zus BOTULINUM NEUROTOXIN
TYPE A,
SYNAPTOSOMAL-ASSOCIA
TED PROTEIN 23
(Clostridium
botulinum;
Homo
sapiens)
4 / 6GLU A 197
MET A 831
LYS A 781
ILE A 827
None
1.26A17.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2W98_B_P1ZB1359_1
(PROSTAGLANDIN
REDUCTASE 2)
4igg CATENIN ALPHA-1
(Homo
sapiens)
4 / 6THR A 727
GLU A 725
MET A 826
ILE A 749
None
1.33A17.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2W98_B_P1ZB1359_1
(PROSTAGLANDIN
REDUCTASE 2)
4igg CATENIN ALPHA-1
(Homo
sapiens)
4 / 6THR A 727
MET A 826
LYS A 717
ILE A 749
None
1.35A17.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2W98_B_P1ZB1359_1
(PROSTAGLANDIN
REDUCTASE 2)
4lk3 UDP-GLUCURONIC ACID
DECARBOXYLASE 1
(Homo
sapiens)
4 / 6GLU A 204
LYS A 361
PHE A 259
ILE A 258
None
None
None
NAD  A 501 (-3.9A)
1.03A21.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2W98_B_P1ZB1359_1
(PROSTAGLANDIN
REDUCTASE 2)
4qn9 N-ACYL-PHOSPHATIDYLE
THANOLAMINE-HYDROLYZ
ING PHOSPHOLIPASE D
(Homo
sapiens)
4 / 6THR A 128
GLU A 138
PHE A 144
ILE A 178
None
1.44A18.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2W98_B_P1ZB1359_1
(PROSTAGLANDIN
REDUCTASE 2)
5fur TRANSCRIPTION
INITIATION FACTOR
IIA SUBUNIT 1
(Homo
sapiens)
4 / 6MET C 358
LYS C 369
PHE C 367
ILE C 366
None
1.39A9.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2W98_B_P1ZB1359_1
(PROSTAGLANDIN
REDUCTASE 2)
5hvf CARBOXYPEPTIDASE B2
(Homo
sapiens)
4 / 6GLU A 385
MET A 287
PHE A 168
ILE A 164
None
1.20A22.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2W98_B_P1ZB1359_1
(PROSTAGLANDIN
REDUCTASE 2)
5n47 FIBRONECTIN
(Homo
sapiens)
4 / 6THR B1423
GLU B1424
MET B1374
PHE B1366
None
1.42A13.74