POTENTIAL TARGETS FROM HUMAN (RESULTS FROM SUB-STRUCTURAL SIMILARITY SEARCHES)
1) User may click on the DrReposER ID (the second column) to get information on the binding sites and drug molecule.
2) Click View (the second last column) to view matched residues and superposition in the NGL viewer (upper right part).
3) User may also click on the Dock (the last column) to get script for molecular docking in UCSF Chimera through AutoDock Vina.

DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MUB_A_OAQA302_0
(SULFOTRANSFERASE)		1x3d FIBRONECTIN TYPE-III
DOMAIN CONTAINING
PROTEIN 3A
(Homo
sapiens)		5 / 12PRO A  23
VAL A 105
GLY A  58
ASP A  56
PHE A  64
None
1.30A17.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MUB_A_OAQA302_0
(SULFOTRANSFERASE)		3cos ALCOHOL
DEHYDROGENASE 4
(Homo
sapiens)		5 / 12HIS A  69
PHE A 147
VAL A 300
PHE A  58
THR A  52
 ZN  A 501 ( 3.3A)
ACY  A 401 (-4.3A)
NAD  A 400 ( 4.2A)
None
None
1.43A21.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MUB_A_OAQA302_0
(SULFOTRANSFERASE)		3h55 ALPHA-N-ACETYLGALACT
OSAMINIDASE
(Homo
sapiens)		5 / 12PRO A 279
MET A 253
LEU A 281
GLY A 157
ASP A 156
None
None
None
None
GLA  A1000 (-3.4A)
1.42A18.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MUB_A_OAQA302_0
(SULFOTRANSFERASE)		4zel DOPAMINE
BETA-HYDROXYLASE
(Homo
sapiens)		5 / 12PHE A  74
LEU A 145
VAL A 101
ASP A 130
MET A  89
None
1.43A17.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MUB_A_OAQA302_0
(SULFOTRANSFERASE)		5epg ALDEHYDE OXIDASE
(Homo
sapiens)		5 / 12LEU A  31
VAL A  54
GLY A 146
THR A  40
MET A 352
None
1.07A10.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MUB_A_OAQA302_0
(SULFOTRANSFERASE)		6dd3 CYTOSOLIC PURINE
5'-NUCLEOTIDASE
(Homo
sapiens)		5 / 12HIS A 209
PHE A 157
GLY A 350
ASP A 356
THR A  56
None
None
None
PO4  A 601 ( 4.9A)
None
1.08Aundetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5BYK_A_OAQA302_0
(SULFOTRANSFERASE)		1gz4 NAD-DEPENDENT MALIC
ENZYME
(Homo
sapiens)		5 / 12PRO A 386
ILE A 323
LEU A 308
VAL A 415
LEU A 288
None
1.03A17.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5BYK_A_OAQA302_0
(SULFOTRANSFERASE)		1r47 ALPHA-GALACTOSIDASE
A
(Homo
sapiens)		5 / 12ILE A 289
LEU A 324
VAL A 254
LEU A 286
THR A 246
None
1.28A20.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5BYK_A_OAQA302_0
(SULFOTRANSFERASE)		1r82 GLYCOPROTEIN-FUCOSYL
GALACTOSIDE
ALPHA-GALACTOSYLTRAN
SFERASE
(Homo
sapiens)		5 / 12ILE A 224
LEU A 324
VAL A 210
LEU A 225
PHE A 229
None
AOG  A 452 ( 4.2A)
None
None
None
1.08A20.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5BYK_A_OAQA302_0
(SULFOTRANSFERASE)		2mki CYTOPLASMIC
POLYADENYLATION
ELEMENT-BINDING
PROTEIN 4
(Homo
sapiens)		5 / 12PRO A  73
ILE A 151
LEU A  72
VAL A 139
PHE A  85
None
1.29A19.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5BYK_A_OAQA302_0
(SULFOTRANSFERASE)		3c5w PP2A-SPECIFIC
METHYLESTERASE PME-1
(Homo
sapiens)		5 / 12ILE P 150
VAL P 138
VAL P 135
THR P 165
MET P 142
None
1.25A21.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5BYK_A_OAQA302_0
(SULFOTRANSFERASE)		3i2v ADENYLYLTRANSFERASE
AND
SULFURTRANSFERASE
MOCS3
(Homo
sapiens)		5 / 12HIS A  17
ILE A  74
VAL A 108
VAL A   2
LEU A  91
None
1.02A19.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5BYK_A_OAQA302_0
(SULFOTRANSFERASE)		3qpx FAB C2507 HEAVY
CHAIN
FAB C2507 LIGHT
CHAIN
(Homo
sapiens;
Rattus
norvegicus;
Homo
sapiens;
Rattus
norvegicus)		5 / 12PRO H 153
VAL H 156
LEU L  40
THR H 114
THR H 171
None
None
None
SO4  H 234 (-3.6A)
None
1.09A19.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5BYK_A_OAQA302_0
(SULFOTRANSFERASE)		4owt INTEGRATOR COMPLEX
SUBUNIT 3
(Homo
sapiens)		5 / 12ILE A 129
LEU A 123
VAL A 146
VAL A 149
PHE A  94
None
1.29A20.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5BYK_A_OAQA302_0
(SULFOTRANSFERASE)		4tvs TORSIN-1A-INTERACTIN
G PROTEIN 1
(Homo
sapiens)		5 / 12ILE A 564
LEU A 490
LEU A 411
PHE A 481
THR A 489
None
1.19A22.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5BYK_A_OAQA302_0
(SULFOTRANSFERASE)		4y63 HISTO-BLOOD GROUP
ABO SYSTEM
TRANSFERASE
(Homo
sapiens)		5 / 12ILE A 224
LEU A 324
VAL A 210
LEU A 225
PHE A 229
None
1.00A18.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5BYK_A_OAQA302_0
(SULFOTRANSFERASE)		5hdt SISTER CHROMATID
COHESION PROTEIN
PDS5 HOMOLOG B
(Homo
sapiens)		5 / 12ILE A 793
LEU A 854
VAL A 833
LEU A 788
THR A 850
None
1.11A13.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5BYK_A_OAQA302_0
(SULFOTRANSFERASE)		5neu INTEGRIN ALPHA-V
(Homo
sapiens)		5 / 12MET A 559
ILE A 586
LEU A 497
VAL A 449
VAL A 475
None
1.07A21.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TIW_A_OAQA302_0
(SULFOTRANSFERASE)		1lv2 HEPATOCYTE NUCLEAR
FACTOR 4-GAMMA
(Homo
sapiens)		5 / 12ILE A 305
VAL A 138
LEU A 324
LEU A 179
LEU A 146
PLM  A 328 (-4.5A)
None
None
PLM  A 328 ( 4.6A)
None
1.26A21.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TIW_A_OAQA302_0
(SULFOTRANSFERASE)		1s1e KV CHANNEL
INTERACTING PROTEIN
1
(Homo
sapiens)		5 / 12MET A 158
ILE A 154
VAL A 215
LEU A  94
LEU A 133
None
1.21A24.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TIW_A_OAQA302_0
(SULFOTRANSFERASE)		1wym TRANSGELIN-2
(Homo
sapiens)		5 / 12ILE A  85
ILE A 102
LEU A 108
LEU A 121
THR A 120
None
1.09A21.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TIW_A_OAQA302_0
(SULFOTRANSFERASE)		2h4u THIOESTERASE
SUPERFAMILY MEMBER 2
(Homo
sapiens)		5 / 12ILE A 102
ILE A  88
LEU A  63
LEU A  55
LEU A  59
None
1.23A21.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TIW_A_OAQA302_0
(SULFOTRANSFERASE)		2hr7 INSULIN RECEPTOR
(Homo
sapiens)		5 / 12VAL A 117
ILE A 119
LEU A  72
LEU A  61
LEU A  63
None
1.28A17.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TIW_A_OAQA302_0
(SULFOTRANSFERASE)		2je1 ACIDIC LEUCINE-RICH
NUCLEAR
PHOSPHOPROTEIN 32
FAMILY MEMBER A
(Homo
sapiens)		5 / 12ILE A 100
VAL A 135
LEU A  95
LEU A 109
LEU A  93
None
1.18A22.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TIW_A_OAQA302_0
(SULFOTRANSFERASE)		2nlk PROTEIN TYROSINE
PHOSPHATASE,
RECEPTOR TYPE, G
VARIANT (FRAGMENT)
(Homo
sapiens)		5 / 12ILE A1139
LEU A1156
ILE A1403
LEU A1132
LEU A1408
None
1.29A16.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TIW_A_OAQA302_0
(SULFOTRANSFERASE)		3a6p EXPORTIN-5
(Homo
sapiens)		5 / 12LEU A 851
ILE A 883
LEU A 923
PHE A 877
LEU A 965
None
1.13A12.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TIW_A_OAQA302_0
(SULFOTRANSFERASE)		3jbz SERINE/THREONINE-PRO
TEIN KINASE MTOR
(Homo
sapiens)		5 / 12ILE A2153
ILE A2228
LEU A2174
LEU A2016
LEU A2172
None
1.04A11.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TIW_A_OAQA302_0
(SULFOTRANSFERASE)		3qfs NADPH--CYTOCHROME
P450 REDUCTASE
(Homo
sapiens)		5 / 12PRO A 363
ILE A 444
ILE A 380
LEU A 341
LEU A 434
None
1.20A18.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TIW_A_OAQA302_0
(SULFOTRANSFERASE)		3w11 INSULIN RECEPTOR
DOMAINS L1-CR
(Homo
sapiens)		5 / 12VAL E 117
ILE E 119
LEU E  72
LEU E  61
LEU E  63
None
1.26A19.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TIW_A_OAQA302_0
(SULFOTRANSFERASE)		4bcx AP-1 COMPLEX SUBUNIT
GAMMA-LIKE 2
(Homo
sapiens)		5 / 12ILE A 696
LEU A 748
VAL A 717
LEU A 682
LEU A 759
None
None
IMD  A1786 ( 4.8A)
None
None
1.22A21.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TIW_A_OAQA302_0
(SULFOTRANSFERASE)		4rxx UBIQUITIN
CARBOXYL-TERMINAL
HYDROLASE 38
(Homo
sapiens)		5 / 12MET A 385
ILE A 381
LEU A 377
LEU A 334
LEU A 321
None
1.16A23.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TIW_A_OAQA302_0
(SULFOTRANSFERASE)		4zxb INSULIN RECEPTOR
(Homo
sapiens)		5 / 12VAL E 117
ILE E 119
LEU E  72
LEU E  61
LEU E  63
None
1.28A13.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TIW_A_OAQA302_0
(SULFOTRANSFERASE)		5exr DNA POLYMERASE ALPHA
SUBUNIT B
(Homo
sapiens)		5 / 12ILE D 539
LEU D 462
PHE D 378
LEU D 499
LEU D 477
None
1.30A17.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TIW_A_OAQA302_0
(SULFOTRANSFERASE)		5gw9 GRANULOCYTE
COLONY-STIMULATING
FACTOR
(Homo
sapiens)		5 / 12LEU A  51
ILE A  96
LEU A  90
PHE A 141
LEU A 107
None
1.25A19.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TIW_A_OAQA302_0
(SULFOTRANSFERASE)		5kqv INSULIN
RECEPTOR,INSULIN
RECEPTOR
(Homo
sapiens)		5 / 12VAL E 117
ILE E 119
LEU E  72
LEU E  61
LEU E  63
None
1.29A18.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TIW_A_OAQA302_0
(SULFOTRANSFERASE)		5l3d LYSINE-SPECIFIC
HISTONE DEMETHYLASE
1A
(Homo
sapiens)		5 / 12LEU A 401
VAL A 414
ILE A 416
LEU A 544
LEU A 386
None
1.12A15.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TIW_A_OAQA302_0
(SULFOTRANSFERASE)		5l3d LYSINE-SPECIFIC
HISTONE DEMETHYLASE
1A
(Homo
sapiens)		5 / 12LEU A 401
VAL A 415
VAL A 414
LEU A 544
LEU A 386
None
0.89A15.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TIW_A_OAQA302_0
(SULFOTRANSFERASE)		5w7w APRATAXIN AND
PNK-LIKE FACTOR
(Homo
sapiens)		5 / 12ILE T  54
LEU T  73
LEU T  45
LEU T   7
LEU T  18
None
1.25Aundetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TIW_A_OAQA302_0
(SULFOTRANSFERASE)		6axf RAS GUANYL-RELEASING
PROTEIN 2
(Homo
sapiens)		5 / 12PRO A  94
ILE A  83
LEU A  40
LEU A  56
LEU A  78
None
1.18A22.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TIW_A_OAQA302_0
(SULFOTRANSFERASE)		6bbp CYTOHESIN-3,ADP-RIBO
SYLATION FACTOR 6
(Homo
sapiens;
Mus
musculus)		5 / 12ILE A 225
ILE A 219
LEU A 193
LEU A 235
LEU A 239
None
1.20Aundetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TIW_A_OAQA302_1
(SULFOTRANSFERASE)		5e84 78 KDA
GLUCOSE-REGULATED
PROTEIN
(Homo
sapiens)		4 / 4TYR A  39
ASP A 391
ASP A 259
SER A 365
ATP  A 801 (-4.8A)
None
ATP  A 801 ( 4.9A)
ATP  A 801 (-3.8A)
1.40A16.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TIW_B_OAQB302_0
(SULFOTRANSFERASE)		2mki CYTOPLASMIC
POLYADENYLATION
ELEMENT-BINDING
PROTEIN 4
(Homo
sapiens)		5 / 12PRO A  73
ILE A 151
LEU A  72
VAL A 139
PHE A  85
None
1.28A20.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TIW_B_OAQB302_0
(SULFOTRANSFERASE)		2qnd FMR1 PROTEIN
(Homo
sapiens)		5 / 12ILE A  92
ASP A 137
VAL A  73
ILE A 103
PHE A 122
None
1.33A17.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TIW_B_OAQB302_0
(SULFOTRANSFERASE)		2wgh RIBONUCLEOSIDE-DIPHO
SPHATE REDUCTASE
LARGE SUBUNIT
(Homo
sapiens)		5 / 12LEU A 131
VAL A 176
ILE A 178
LEU A 205
THR A 204
None
1.27A16.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TIW_B_OAQB302_0
(SULFOTRANSFERASE)		4fdh CYTOCHROME P450
11B2, MITOCHONDRIAL
(Homo
sapiens)		5 / 12PRO A  77
LEU A  93
ILE A 397
LEU A 402
THR A 401
None
1.05A20.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TIW_B_OAQB302_0
(SULFOTRANSFERASE)		4idj FAB HEAVY CHAIN
FAB LIGHT CHAIN
(Homo
sapiens;
Homo
sapiens)		5 / 12PRO L 113
MET L 175
VAL L 115
ILE L 117
LEU H 124
None
1.29A20.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TIW_B_OAQB302_0
(SULFOTRANSFERASE)		4kkj TRANSCOBALAMIN-1
(Homo
sapiens)		5 / 12ILE A   2
ASP A 278
LEU A 277
LEU A 246
THR A 245
None
1.18A18.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TIW_B_OAQB302_0
(SULFOTRANSFERASE)		4wip SEGMENT POLARITY
PROTEIN DISHEVELLED
HOMOLOG DVL-2
(Homo
sapiens)		5 / 12ILE A  71
LEU A  89
ILE A  38
PHE A  57
SER A  87
None
1.32A16.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TIW_B_OAQB302_0
(SULFOTRANSFERASE)		5h64 SERINE/THREONINE-PRO
TEIN KINASE MTOR
(Homo
sapiens)		5 / 12ILE A1118
LEU A1136
ILE A1155
PHE A1122
LEU A1111
None
1.33A6.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TIW_B_OAQB302_0
(SULFOTRANSFERASE)		5n47 FIBRONECTIN
(Homo
sapiens)		5 / 12ILE B1336
VAL B1276
ILE B1278
SER B1274
LEU B1328
None
1.32Aundetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TIW_B_OAQB302_0
(SULFOTRANSFERASE)		5nst LIGHT CHAIN OF
ANTIBODY MGD21
HEAVY CHAIN OF
ANTIBODY MGD21
(Homo
sapiens;
Homo
sapiens)		5 / 12PRO A 113
MET A 175
VAL A 115
ILE A 117
LEU B 261
None
1.29A18.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TIW_B_OAQB302_0
(SULFOTRANSFERASE)		6c90 EXOSOME RNA HELICASE
MTR4,EXOSOME RNA
HELICASE MTR4
(Homo
sapiens)		5 / 12ILE A 186
LEU A 211
SER A 195
LEU A 236
THR A 269
None
1.18Aundetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TIW_B_OAQB302_0
(SULFOTRANSFERASE)		6d6q EXOSOME RNA HELICASE
MTR4
(Homo
sapiens)		5 / 12ILE M 186
LEU M 211
SER M 195
LEU M 236
THR M 269
None
1.05Aundetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TIY_A_OAQA302_0
(SULFOTRANSFERASE)		4et7 EPHRIN TYPE-A
RECEPTOR 5
(Homo
sapiens)		5 / 11MET A 153
ILE A 177
VAL A 226
LEU A 134
THR A 133
None
1.47A22.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TIY_A_OAQA302_0
(SULFOTRANSFERASE)		5ff8 G/T
MISMATCH-SPECIFIC
THYMINE DNA
GLYCOSYLASE
(Homo
sapiens)		5 / 11MET A 192
ILE A 137
VAL A 216
PHE A 229
LEU A 128
None
1.38A20.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TIY_A_OAQA302_0
(SULFOTRANSFERASE)		5tbk IMPORTIN SUBUNIT
ALPHA-3
(Homo
sapiens)		5 / 11PRO A 129
VAL A 173
SER A 168
LEU A 139
THR A 140
None
1.31A18.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6B50_A_OAQA302_0
(SULFOTRANSFERASE
OXAMNIQUINE
RESISTANCE PROTEIN)		4m6w FANCONI
ANEMIA-ASSOCIATED
PROTEIN OF 24 KDA
(Homo
sapiens)		5 / 12ASP B  65
LEU B  66
VAL B  90
VAL B  91
SER B  97
None
1.34A23.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6B52_A_OAQA302_0
(SULFOTRANSFERASE)		1gz4 NAD-DEPENDENT MALIC
ENZYME
(Homo
sapiens)		5 / 12PRO A 386
ILE A 323
LEU A 308
VAL A 415
LEU A 288
None
1.10A19.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6B52_A_OAQA302_0
(SULFOTRANSFERASE)		1r47 ALPHA-GALACTOSIDASE
A
(Homo
sapiens)		5 / 12ILE A 289
LEU A 324
VAL A 254
LEU A 286
THR A 246
None
1.19A22.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6B52_A_OAQA302_0
(SULFOTRANSFERASE)		2dw4 LYSINE-SPECIFIC
HISTONE DEMETHYLASE
1
(Homo
sapiens)		5 / 12LEU A 401
VAL A 415
VAL A 414
LEU A 544
LEU A 386
None
1.02A16.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6B52_A_OAQA302_0
(SULFOTRANSFERASE)		2qki COMPLEMENT C3
(Homo
sapiens)		5 / 12MET C1385
ILE C1383
LEU C1381
PHE C1439
LEU C1341
None
1.09A20.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6B52_A_OAQA302_0
(SULFOTRANSFERASE)		2xtp GTPASE IMAP FAMILY
MEMBER 2
(Homo
sapiens)		6 / 12ILE A  75
LEU A 101
VAL A  28
PHE A  48
SER A  62
LEU A 144
None
1.36A23.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6B52_A_OAQA302_0
(SULFOTRANSFERASE)		2xwb COMPLEMENT C3B
ALPHA' CHAIN
(Homo
sapiens)		5 / 12MET B1385
ILE B1383
LEU B1381
PHE B1439
LEU B1341
None
1.08A14.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6B52_A_OAQA302_0
(SULFOTRANSFERASE)		3j9f POLIOVIRUS RECEPTOR
(Homo
sapiens)		5 / 12ILE 9 299
LEU 9 257
LEU 9 297
LEU 9 286
THR 9 281
None
1.21A15.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6B52_A_OAQA302_0
(SULFOTRANSFERASE)		3pk1 INDUCED MYELOID
LEUKEMIA CELL
DIFFERENTIATION
PROTEIN MCL-1
(Homo
sapiens)		5 / 12ILE A 268
LEU A 179
VAL A 297
SER A 178
MET A 250
None
1.11A23.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6B52_A_OAQA302_0
(SULFOTRANSFERASE)		3u1k POLYRIBONUCLEOTIDE
NUCLEOTIDYLTRANSFERA
SE 1, MITOCHONDRIAL
(Homo
sapiens)		5 / 12ILE A 283
VAL A 343
VAL A 342
LEU A 290
THR A 320
None
1.05A17.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6B52_A_OAQA302_0
(SULFOTRANSFERASE)		3vzg ZYMOGEN GRANULE
MEMBRANE PROTEIN 16
(Homo
sapiens)		5 / 12ILE A  49
VAL A  54
LEU A  88
SER A  73
LEU A 118
None
1.19A20.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6B52_A_OAQA302_0
(SULFOTRANSFERASE)		3wyr KILLER CELL
IMMUNOGLOBULIN-LIKE
RECEPTOR 2DL4
(Homo
sapiens)		5 / 12PRO A 180
MET A  95
ILE A  94
LEU A  26
LEU A  50
None
1.16A18.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6B52_A_OAQA302_0
(SULFOTRANSFERASE)		4f92 U5 SMALL NUCLEAR
RIBONUCLEOPROTEIN
200 KDA HELICASE
(Homo
sapiens)		5 / 12PRO B1182
ILE B1204
LEU B1202
PHE B1239
LEU B1282
None
1.18A10.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6B52_A_OAQA302_0
(SULFOTRANSFERASE)		5ezv 5'-AMP-ACTIVATED
PROTEIN KINASE
SUBUNIT BETA-1
(Homo
sapiens)		5 / 12ILE B 214
LEU B 210
LEU B 228
LEU B 265
THR B 264
None
1.21A22.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6B52_A_OAQA302_0
(SULFOTRANSFERASE)		5jsb INDUCED MYELOID
LEUKEMIA CELL
DIFFERENTIATION
PROTEIN MCL-1
(Homo
sapiens)		5 / 12ILE A 268
LEU A 179
VAL A 297
SER A 178
MET A 250
None
1.10A20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6B52_A_OAQA302_0
(SULFOTRANSFERASE)		5l0o RAS
GTPASE-ACTIVATING-LI
KE PROTEIN IQGAP1
(Homo
sapiens)		5 / 12ILE A 126
VAL A  90
VAL A  89
LEU A 159
LEU A  81
None
1.14A24.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6B52_A_OAQA302_0
(SULFOTRANSFERASE)		5l3d LYSINE-SPECIFIC
HISTONE DEMETHYLASE
1A
(Homo
sapiens)		5 / 12LEU A 401
VAL A 415
VAL A 414
LEU A 544
LEU A 386
None
0.95A15.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6B52_A_OAQA302_0
(SULFOTRANSFERASE)		5mev INDUCED MYELOID
LEUKEMIA CELL
DIFFERENTIATION
PROTEIN MCL-1
HOMOLOG,INDUCED
MYELOID LEUKEMIA
CELL DIFFERENTIATION
PROTEIN MCL-1
(Homo
sapiens;
Mus
musculus)		5 / 12ILE A 268
LEU A 179
VAL A 297
SER A 178
MET A 250
None
1.16A18.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6B52_A_OAQA302_0
(SULFOTRANSFERASE)		5neu INTEGRIN ALPHA-V
(Homo
sapiens)		5 / 12MET A 559
ILE A 586
LEU A 497
VAL A 449
VAL A 475
None
1.15A21.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6B54_A_OAQA302_0
(SULFOTRANSFERASE)		1xnj BIFUNCTIONAL
3'-PHOSPHOADENOSINE
5'-PHOSPHOSULFATE
SYNTHETASE 1
(Homo
sapiens)		5 / 12MET B 264
ILE B 259
VAL B 383
LEU B 257
LEU B 320
None
1.14A21.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6B54_A_OAQA302_0
(SULFOTRANSFERASE)		2b9e NOL1/NOP2/SUN DOMAIN
FAMILY, MEMBER 5
ISOFORM 2
(Homo
sapiens)		5 / 12LEU A 259
LEU A 342
PHE A 337
THR A 347
LEU A 346
SAM  A1201 (-4.5A)
None
SAM  A1201 (-4.2A)
None
None
1.12A20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6B54_A_OAQA302_0
(SULFOTRANSFERASE)		2pfr ARYLAMINE
N-ACETYLTRANSFERASE
2
(Homo
sapiens)		5 / 12ILE A 189
LEU A 288
LEU A 161
PHE A  93
LEU A 135
None
UNX  A1009 ( 4.2A)
None
COA  A 401 ( 3.8A)
None
1.02A24.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6B54_A_OAQA302_0
(SULFOTRANSFERASE)		3ceg BACULOVIRAL IAP
REPEAT-CONTAINING
PROTEIN 6
(Homo
sapiens)		5 / 12ILE A4703
LEU A4769
VAL A4708
THR A4619
LEU A4617
None
1.24A20.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6B54_A_OAQA302_0
(SULFOTRANSFERASE)		3fbk REGULATOR OF
G-PROTEIN SIGNALING
3
(Homo
sapiens)		5 / 12ILE A  52
VAL A 118
LEU A  50
MET A 134
LEU A 114
None
1.25A21.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6B54_A_OAQA302_0
(SULFOTRANSFERASE)		4r3i YTH
DOMAIN-CONTAINING
PROTEIN 1
(Homo
sapiens)		5 / 12ILE A 448
VAL A 397
LEU A 348
THR A 486
LEU A 490
None
1.23A22.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6B54_A_OAQA302_0
(SULFOTRANSFERASE)		4tt6 ATPASE FAMILY AAA
DOMAIN-CONTAINING
PROTEIN 2
(Homo
sapiens)		5 / 12ASP A1030
LEU A1031
ASP A1039
LEU A1040
THR A 997
None
1.17A20.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6B54_A_OAQA302_0
(SULFOTRANSFERASE)		5hdt SISTER CHROMATID
COHESION PROTEIN
PDS5 HOMOLOG B
(Homo
sapiens)		5 / 12ILE A 793
LEU A 854
VAL A 833
LEU A 788
THR A 850
None
1.13A12.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6B54_A_OAQA302_0
(SULFOTRANSFERASE)		5k1b WD REPEAT-CONTAINING
PROTEIN 48
(Homo
sapiens)		5 / 12LEU B 525
VAL B  15
LEU B 470
THR B 545
LEU B 466
None
1.18A17.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6B54_A_OAQA302_0
(SULFOTRANSFERASE)		5syt CAAX PRENYL PROTEASE
1 HOMOLOG
(Homo
sapiens)		5 / 12ILE A  19
LEU A  24
LEU A 372
PHE A 376
LEU A 366
C8E  A 513 ( 3.8A)
None
C8E  A 513 ( 4.7A)
None
C8E  A 513 ( 4.7A)
1.03A22.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6B54_A_OAQA302_0
(SULFOTRANSFERASE)		5xbk IMPORTIN-4
(Homo
sapiens)		5 / 12VAL D 768
LEU D 796
THR D 808
THR D 776
LEU D 779
None
1.13Aundetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6B54_A_OAQA302_0
(SULFOTRANSFERASE)		6en4 SPLICING FACTOR 3B
SUBUNIT 3
(Homo
sapiens)		5 / 12ILE A 256
LEU A 249
PHE A 287
THR A 314
LEU A 315
None
1.19Aundetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6B54_A_OAQA302_0
(SULFOTRANSFERASE)		6ez8 HUNTINGTIN
(Homo
sapiens)		5 / 12MET A 155
ILE A 151
LEU A 192
LEU A 147
LEU A 129
None
1.25Aundetectable