POTENTIAL TARGETS FROM HUMAN (RESULTS FROM SUB-STRUCTURAL SIMILARITY SEARCHES)1) User may click on the DrReposER ID (the second column) to get information on the binding sites and drug molecule.
2) Click View (the second last column) to view matched residues and superposition in the NGL viewer (upper right part).
3) User may also click on the Dock (the last column) to get script for molecular docking in UCSF Chimera through AutoDock Vina.

	DrReposER ID / Desc.	Hit PDBID	Hit Macromolecule	Res. Matches	Interface	HETATM	RMSD	Seq. Identity (%)	View	Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3V35_A_NTIA317_1 (ALDOSE REDUCTASE)	2c11	MEMBRANE COPPER AMINE OXIDASE (Homo sapiens)	4 / 8	VAL A 171 HIS A 251 PRO A 653 TRP A 654	None	1.23A	18.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3V35_A_NTIA317_1 (ALDOSE REDUCTASE)	2g5t	DIPEPTIDYL PEPTIDASE 4 (Homo sapiens)	4 / 8	TRP A 315 VAL A 303 TRP A 215 PHE A 208	None	1.34A	18.29
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	3V35_A_NTIA317_1 (ALDOSE REDUCTASE)	2is7	ALDOSE REDUCTASE (Homo sapiens)	8 / 8	TRP A  20 VAL A  47 TRP A  79 HIS A 110 TRP A 111 PHE A 122 PRO A 218 TRP A 219	2CL  A 317 ( 3.4A) 2CL  A 317 (-4.2A) None 2CL  A 317 ( 3.8A) NAP  A 316 ( 4.0A) 2CL  A 317 ( 4.9A) None None	0.34A	99.05
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	3V35_A_NTIA317_1 (ALDOSE REDUCTASE)	2is7	ALDOSE REDUCTASE (Homo sapiens)	4 / 8	TRP A  79 HIS A 110 TRP A 111 PHE A 115	None 2CL  A 317 ( 3.8A) NAP  A 316 ( 4.0A) None	1.38A	99.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3V35_A_NTIA317_1 (ALDOSE REDUCTASE)	3ld8	BIFUNCTIONAL ARGININE DEMETHYLASE AND LYSYL-HYDROXYLASE JMJD6 (Homo sapiens)	4 / 8	VAL A 302 TRP A 298 PHE A 294 PRO A 170	None	1.49A	20.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3V35_A_NTIA317_1 (ALDOSE REDUCTASE)	3qci	RECEPTOR-TYPE TYROSINE-PROTEIN PHOSPHATASE GAMMA (Homo sapiens)	4 / 8	TRP A1026 HIS A1022 PHE A1041 PRO A1032	None None NX3  A2001 (-4.1A) NX3  A2001 (-4.0A)	1.40A	19.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3V35_A_NTIA317_1 (ALDOSE REDUCTASE)	4acq	ALPHA-2-MACROGLOBULI N (Homo sapiens)	4 / 8	VAL A 355 HIS A 446 PHE A 407 PRO A 364	None None None NAG  A2401 (-3.9A)	1.46A	12.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3V35_A_NTIA317_1 (ALDOSE REDUCTASE)	4gga	CELL DIVISION CYCLE PROTEIN 20 HOMOLOG (Homo sapiens)	4 / 8	TRP A 407 PHE A 473 PRO A 365 TRP A 366	None	1.22A	21.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3V35_A_NTIA317_1 (ALDOSE REDUCTASE)	4xwh	ALPHA-N-ACETYLGLUCOS AMINIDASE (Homo sapiens)	4 / 8	VAL A 454 HIS A 408 PRO A 427 TRP A 404	None	1.47A	16.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3V35_A_NTIA317_1 (ALDOSE REDUCTASE)	5lcw	CELL DIVISION CYCLE PROTEIN 20 HOMOLOG (Homo sapiens)	4 / 8	TRP Q 407 PHE Q 473 PRO Q 365 TRP Q 366	None	1.20A	21.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3V35_A_NTIA317_1 (ALDOSE REDUCTASE)	5lcw	CELL DIVISION CYCLE PROTEIN 20 HOMOLOG (Homo sapiens)	4 / 8	TRP R 407 PHE R 473 PRO R 365 TRP R 366	None	1.20A	20.89
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	3V35_A_NTIA317_1 (ALDOSE REDUCTASE)	5liy	ALDO-KETO REDUCTASE FAMILY 1 MEMBER B10 (Homo sapiens)	6 / 8	TRP X  21 VAL X  48 TRP X  80 HIS X 111 PRO X 219 TRP X 220	DQP  X 402 ( 3.5A) DQP  X 402 ( 4.5A) None DQP  X 402 ( 4.1A) DQP  X 402 (-4.5A) None	0.69A	66.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3V35_A_NTIA317_1 (ALDOSE REDUCTASE)	5wy0	SMALL RNA 2'-O-METHYLTRANSFERA SE (Homo sapiens)	4 / 8	VAL A 167 TRP A 163 PHE A 115 PRO A 125	None	0.95A	14.53