POTENTIAL TARGETS FROM HUMAN (RESULTS FROM SUB-STRUCTURAL SIMILARITY SEARCHES)
1) User may click on the DrReposER ID (the second column) to get information on the binding sites and drug molecule.
2) Click View (the second last column) to view matched residues and superposition in the NGL viewer (upper right part).
3) User may also click on the Dock (the last column) to get script for molecular docking in UCSF Chimera through AutoDock Vina.

DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1AJ6_A_NOVA1_1
(GYRASE)		1kgd PERIPHERAL PLASMA
MEMBRANE CASK
(Homo
sapiens)		5 / 9ASN A 891
GLU A 896
ARG A 899
ILE A 898
ILE A 750
None
1.36A24.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1AJ6_A_NOVA1_1
(GYRASE)		1sy6 OKT3 FAB HEAVY CHAIN
T-CELL SURFACE
GLYCOPROTEIN CD3
GAMMA/EPSILON CHAIN
(Homo
sapiens;
Mus
musculus)		5 / 9GLU A 141
ARG A 186
ILE H  51
ALA H  79
THR H  58
None
1.32A20.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1AJ6_A_NOVA1_1
(GYRASE)		1zxn DNA TOPOISOMERASE
II, ALPHA ISOZYME
(Homo
sapiens)		5 / 9ASN A  91
ILE A 125
PRO A 126
ILE A 141
THR A 215
 MG  A 900 ( 2.5A)
ADP  A 901 (-4.4A)
None
ADP  A 901 (-3.7A)
ADP  A 901 ( 4.1A)
0.80A18.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1AJ6_A_NOVA1_1
(GYRASE)		2nn6 POLYMYOSITIS/SCLEROD
ERMA AUTOANTIGEN 1
(Homo
sapiens)		5 / 9GLU A 211
ASP A 142
ILE A 145
ILE A 146
THR A  53
None
1.34A18.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1AJ6_A_NOVA1_1
(GYRASE)		3t6a BREAST CANCER
ANTI-ESTROGEN
RESISTANCE PROTEIN 3
(Homo
sapiens)		5 / 9ASP A 622
ILE A 613
ALA A 653
ILE A 659
THR A 626
None
1.43A19.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1AJ6_A_NOVA1_1
(GYRASE)		4p7h MYOSIN-7,GREEN
FLUORESCENT PROTEIN
(Aequorea
victoria;
Homo
sapiens)		5 / 9ASP A 461
ILE A 192
ALA A 196
ILE A 221
THR A 188
None
1.48A12.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1AJ6_A_NOVA1_1
(GYRASE)		5dis MALTOSE-BINDING
PERIPLASMIC
PROTEIN,NUCLEAR PORE
COMPLEX PROTEIN
NUP214
(Escherichia
coli;
Homo
sapiens)		5 / 9ASN D 272
GLU D 278
ILE D 266
ALA D 264
ILE D  59
None
1.48A17.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1AJ6_A_NOVA1_1
(GYRASE)		5k10 ISOCITRATE
DEHYDROGENASE [NADP]
CYTOPLASMIC
(Homo
sapiens)		5 / 9ASP A 299
ILE A  64
ALA A  60
ILE A  99
THR A 302
None
1.39A20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1AJ6_A_NOVA1_1
(GYRASE)		5kel C2G4 VARIABLE FAB
DOMAIN HEAVY CHAIN
(Homo
sapiens)		5 / 9ASP H  73
ARG H  94
ILE H  51
ALA H  49
ILE H  69
None
1.31A17.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KIJ_A_NOVA400_1
(DNA GYRASE SUBUNIT B)		1zxn DNA TOPOISOMERASE
II, ALPHA ISOZYME
(Homo
sapiens)		5 / 12ASP A  94
ILE A 125
PRO A 126
ILE A 141
THR A 215
None
ADP  A 901 (-4.4A)
None
ADP  A 901 (-3.7A)
ADP  A 901 ( 4.1A)
0.85A26.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KIJ_A_NOVA400_1
(DNA GYRASE SUBUNIT B)		2nn6 POLYMYOSITIS/SCLEROD
ERMA AUTOANTIGEN 1
(Homo
sapiens)		5 / 12GLU A 211
ASP A 142
ILE A 145
ILE A 146
THR A  53
None
1.40A21.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KIJ_A_NOVA400_1
(DNA GYRASE SUBUNIT B)		4agd VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 2
(Homo
sapiens)		5 / 12ASP A 807
ASP A1087
ARG A1027
ILE A 804
ILE A 888
None
1.49A23.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KIJ_A_NOVA400_1
(DNA GYRASE SUBUNIT B)		4idt MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE KINASE 14
(Homo
sapiens)		5 / 12GLU A 617
ARG A 673
ILE A 618
PRO A 619
ILE A 630
None
1.21A24.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KIJ_A_NOVA400_1
(DNA GYRASE SUBUNIT B)		4ri0 SERINE PROTEASE
HTRA3
(Homo
sapiens)		5 / 12ILE A 332
PRO A 333
ASP A 335
ILE A 228
THR A 321
None
1.45A23.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KIJ_A_NOVA400_1
(DNA GYRASE SUBUNIT B)		5do7 ATP-BINDING CASSETTE
SUB-FAMILY G MEMBER
5
(Homo
sapiens)		6 / 12ASP A 182
GLU A 146
ARG A 381
ILE A 185
ILE A 193
THR A 147
None
1.50A20.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KIJ_A_NOVA400_2
(DNA GYRASE SUBUNIT B)		1hup MANNOSE-BINDING
PROTEIN
(Homo
sapiens)		3 / 3ASN A 212
PHE A 163
VAL A 214
SO4  A 304 ( 3.2A)
None
None
0.66A16.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KIJ_A_NOVA400_2
(DNA GYRASE SUBUNIT B)		1jdp ATRIAL NATRIURETIC
PEPTIDE CLEARANCE
RECEPTOR
(Homo
sapiens)		3 / 3ASN A 310
PHE A 290
VAL A 313
None
0.82A22.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KIJ_A_NOVA400_2
(DNA GYRASE SUBUNIT B)		1jxk ALPHA-AMYLASE,
SALIVARY
(Homo
sapiens)		3 / 3ASN A  87
PHE A  79
VAL A 191
None
0.87A21.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KIJ_A_NOVA400_2
(DNA GYRASE SUBUNIT B)		1lcy HTRA2 SERINE
PROTEASE
(Homo
sapiens)		3 / 3ASN A  63
PHE A  52
VAL A 187
None
0.72A24.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KIJ_A_NOVA400_2
(DNA GYRASE SUBUNIT B)		1ne7 GLUCOSAMINE-6-PHOSPH
ATE ISOMERASE
(Homo
sapiens)		3 / 3ASN A 147
PHE A 134
VAL A 188
None
0.69A23.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KIJ_A_NOVA400_2
(DNA GYRASE SUBUNIT B)		1wh0 UBIQUITIN
CARBOXYL-TERMINAL
HYDROLASE 19
(Homo
sapiens)		3 / 3ASN A  22
PHE A  66
VAL A  20
None
0.85A15.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KIJ_A_NOVA400_2
(DNA GYRASE SUBUNIT B)		1xkt FATTY ACID SYNTHASE
(Homo
sapiens)		3 / 3ASN A2463
PHE A2315
VAL A2467
None
0.68A22.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KIJ_A_NOVA400_2
(DNA GYRASE SUBUNIT B)		2bx6 XRP2 PROTEIN
(Homo
sapiens)		3 / 3ASN A 168
PHE A 340
VAL A 270
None
0.73A22.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KIJ_A_NOVA400_2
(DNA GYRASE SUBUNIT B)		2cqd RNA-BINDING REGION
CONTAINING PROTEIN 1
(Homo
sapiens)		3 / 3ASN A  84
PHE A  31
VAL A  15
None
0.87A16.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KIJ_A_NOVA400_2
(DNA GYRASE SUBUNIT B)		2eje GENERAL
TRANSCRIPTION FACTOR
II-I
(Homo
sapiens)		3 / 3ASN A  27
PHE A  69
VAL A  46
None
0.59A17.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KIJ_A_NOVA400_2
(DNA GYRASE SUBUNIT B)		2ls8 C-TYPE LECTIN DOMAIN
FAMILY 4 MEMBER D
(Homo
sapiens)		3 / 3ASN A 114
PHE A  61
VAL A 116
None
0.81A16.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KIJ_A_NOVA400_2
(DNA GYRASE SUBUNIT B)		3lm5 SERINE/THREONINE-PRO
TEIN KINASE 17B
(Homo
sapiens)		3 / 3ASN A  95
PHE A 180
VAL A  93
None
0.83A20.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KIJ_A_NOVA400_2
(DNA GYRASE SUBUNIT B)		3wh3 C-TYPE LECTIN DOMAIN
FAMILY 4 MEMBER E
(Homo
sapiens)		3 / 3ASN A 193
PHE A 138
VAL A 195
 CA  A 500 (-3.0A)
None
None
0.75A16.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KIJ_A_NOVA400_2
(DNA GYRASE SUBUNIT B)		3whd C-TYPE LECTIN DOMAIN
FAMILY 4 MEMBER D
(Homo
sapiens)		3 / 3ASN A 195
PHE A 142
VAL A 197
 CA  A 501 (-3.1A)
None
None
0.59A16.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KIJ_A_NOVA400_2
(DNA GYRASE SUBUNIT B)		4m18 PULMONARY
SURFACTANT-ASSOCIATE
D PROTEIN D
(Homo
sapiens)		3 / 3ASN A 341
PHE A 292
VAL A 343
MAN  A 406 ( 2.6A)
None
MAN  A 406 ( 4.7A)
0.60A17.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KIJ_A_NOVA400_2
(DNA GYRASE SUBUNIT B)		4ymd COLLECTIN-11
(Homo
sapiens)		3 / 3ASN A 252
PHE A 202
VAL A 254
MAN  A 302 ( 2.6A)
None
MAN  A 302 ( 4.7A)
0.74A18.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KIJ_A_NOVA400_2
(DNA GYRASE SUBUNIT B)		4zgz ANTIZYME INHIBITOR 1
(Homo
sapiens)		3 / 3ASN A 317
PHE A 324
VAL A 285
None
0.63A21.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KIJ_A_NOVA400_2
(DNA GYRASE SUBUNIT B)		5b1w C-TYPE LECTIN DOMAIN
FAMILY 4 MEMBER A
(Homo
sapiens)		3 / 3ASN A 218
PHE A 164
VAL A 220
 CA  A2002 (-3.0A)
None
None
0.65A17.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KIJ_A_NOVA400_2
(DNA GYRASE SUBUNIT B)		5bwa ORNITHINE
DECARBOXYLASE
(Homo
sapiens)		3 / 3ASN A 319
PHE A 326
VAL A 288
None
0.61A22.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KIJ_A_NOVA400_2
(DNA GYRASE SUBUNIT B)		5dqs ELONGATION FACTOR
1-GAMMA
(Homo
sapiens)		3 / 3ASN A  12
PHE A  40
VAL A  58
None
0.75A19.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KIJ_A_NOVA400_2
(DNA GYRASE SUBUNIT B)		5vyb C-TYPE LECTIN DOMAIN
FAMILY 6 MEMBER A
(Homo
sapiens)		3 / 3ASN A 190
PHE A 137
VAL A 192
MAN  A 302 ( 2.9A)
None
MAN  A 302 ( 4.6A)
0.74A16.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KIJ_B_NOVB444_1
(DNA GYRASE SUBUNIT B)		1jmc PROTEIN (REPLICATION
PROTEIN A (RPA))
(Homo
sapiens)		5 / 12GLU A 225
ILE A 233
ASP A 275
ILE A 187
ALA A 201
None
1.07A19.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KIJ_B_NOVB444_1
(DNA GYRASE SUBUNIT B)		1zxn DNA TOPOISOMERASE
II, ALPHA ISOZYME
(Homo
sapiens)		5 / 12ASN A  91
ILE A 125
PRO A 126
ILE A 141
THR A 215
 MG  A 900 ( 2.5A)
ADP  A 901 (-4.4A)
None
ADP  A 901 (-3.7A)
ADP  A 901 ( 4.1A)
0.87A26.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KIJ_B_NOVB444_1
(DNA GYRASE SUBUNIT B)		4i3r HEAVY CHAIN OF
VRC-PG04 FAB
(Homo
sapiens)		5 / 12ASP H  62
ILE H  82
ILE H 109
TYR H  90
ALA H  88
None
1.12A18.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KIJ_B_NOVB444_1
(DNA GYRASE SUBUNIT B)		4idt MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE KINASE 14
(Homo
sapiens)		5 / 12GLU A 617
ARG A 673
ILE A 618
PRO A 619
ILE A 630
None
1.23A24.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KIJ_B_NOVB444_1
(DNA GYRASE SUBUNIT B)		4ny4 CYTOCHROME P450 3A4
(Homo
sapiens)		5 / 12GLU A 374
ARG A 372
ILE A 396
PRO A 397
ILE A  84
2QH  A 602 ( 4.8A)
None
None
None
None
1.14A20.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KIJ_B_NOVB444_1
(DNA GYRASE SUBUNIT B)		4u1r ATP-DEPENDENT
6-PHOSPHOFRUCTOKINAS
E, PLATELET TYPE
(Homo
sapiens)		5 / 12GLU A 273
ARG A 219
ASP A 128
ILE A 174
ALA A 190
None
None
ATP  A 801 (-2.6A)
None
None
1.10A20.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KIJ_B_NOVB444_2
(DNA GYRASE SUBUNIT B)		1q1q SULFOTRANSFERASE
FAMILY, CYTOSOLIC,
2B, MEMBER 1 ISOFORM
A
(Homo
sapiens)		3 / 3ASP A  46
PHE A  49
VAL A  43
None
0.66A21.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KIJ_B_NOVB444_2
(DNA GYRASE SUBUNIT B)		1q20 SULFOTRANSFERASE
FAMILY, CYTOSOLIC,
2B, MEMBER 1 ISOFORM
B
(Homo
sapiens)		3 / 3ASP A  61
PHE A  64
VAL A  58
None
0.70A21.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KIJ_B_NOVB444_2
(DNA GYRASE SUBUNIT B)		1wwy THIOREDOXIN-LIKE
PROTEIN 1
(Homo
sapiens)		3 / 3ASP A  33
PHE A 149
VAL A  55
None
0.68A19.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KIJ_B_NOVB444_2
(DNA GYRASE SUBUNIT B)		3dkp PROBABLE
ATP-DEPENDENT RNA
HELICASE DDX52
(Homo
sapiens)		3 / 3ASP A 321
PHE A 331
VAL A 317
None
0.74A21.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KIJ_B_NOVB444_2
(DNA GYRASE SUBUNIT B)		3iiw POLYCOMB PROTEIN EED
(Homo
sapiens)		3 / 3ASP A 338
PHE A 299
VAL A 350
None
0.65A21.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KIJ_B_NOVB444_2
(DNA GYRASE SUBUNIT B)		3tvl THIAMINE-TRIPHOSPHAT
ASE
(Homo
sapiens)		3 / 3ASP A 147
PHE A  12
VAL A 144
None
0.78A20.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KIJ_B_NOVB444_2
(DNA GYRASE SUBUNIT B)		3uem PROTEIN
DISULFIDE-ISOMERASE
(Homo
sapiens)		3 / 3ASP A 456
PHE A 446
VAL A 435
None
0.71A23.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KIJ_B_NOVB444_2
(DNA GYRASE SUBUNIT B)		4kt1 LEUCINE-RICH
REPEAT-CONTAINING
G-PROTEIN COUPLED
RECEPTOR 4
(Homo
sapiens)		3 / 3ASP A 147
PHE A 149
VAL A 144
None
0.54A20.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KIJ_B_NOVB444_2
(DNA GYRASE SUBUNIT B)		4nre ARACHIDONATE
15-LIPOXYGENASE B
(Homo
sapiens)		3 / 3ASP A  60
PHE A   4
VAL A  64
None
0.75A21.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KIJ_B_NOVB444_2
(DNA GYRASE SUBUNIT B)		4qxe LEUCINE-RICH
REPEAT-CONTAINING
G-PROTEIN COUPLED
RECEPTOR 4, LINKER,
VARIABLE LYMPHOCYTE
RECEPTOR B
(Eptatretus
burgeri;
Homo
sapiens)		3 / 3ASP A 147
PHE A 149
VAL A 144
None
0.59A21.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KIJ_B_NOVB444_2
(DNA GYRASE SUBUNIT B)		4qxf LEUCINE-RICH
REPEAT-CONTAINING
G-PROTEIN COUPLED
RECEPTOR 4, VARIABLE
LYMPHOCYTE RECEPTOR
B
(Eptatretus
burgeri;
Homo
sapiens)		3 / 3ASP A 147
PHE A 149
VAL A 144
None
0.60A19.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KIJ_B_NOVB444_2
(DNA GYRASE SUBUNIT B)		4y1y GALECTIN-1
(Homo
sapiens)		3 / 3ASP A  26
PHE A  49
VAL A  23
None
0.78A18.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KIJ_B_NOVB444_2
(DNA GYRASE SUBUNIT B)		5iaa UBIQUITIN-LIKE
MODIFIER-ACTIVATING
ENZYME 5
(Homo
sapiens)		3 / 3ASP A 106
PHE A 118
VAL A  81
None
0.70A25.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KIJ_B_NOVB444_2
(DNA GYRASE SUBUNIT B)		5ikp GLYCOGEN
PHOSPHORYLASE, BRAIN
FORM
(Homo
sapiens)		3 / 3ASP A 564
PHE A 681
VAL A 567
None
0.68A18.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KIJ_B_NOVB444_2
(DNA GYRASE SUBUNIT B)		5in7 NEURONAL MIGRATION
PROTEIN DOUBLECORTIN
(Homo
sapiens)		3 / 3ASP A 167
PHE A 138
VAL A 153
None
0.75A13.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KIJ_B_NOVB444_2
(DNA GYRASE SUBUNIT B)		5mc7 COATOMER SUBUNIT
ZETA-1
(Homo
sapiens)		3 / 3ASP A  74
PHE A  77
VAL A 109
None
0.76A16.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KIJ_B_NOVB444_2
(DNA GYRASE SUBUNIT B)		6fm9 UDP-N-ACETYLGLUCOSAM
INE--DOLICHYL-PHOSPH
ATE
N-ACETYLGLUCOSAMINEP
HOSPHOTRANSFERASE
(Homo
sapiens)		3 / 3ASP A 116
PHE A  36
VAL A  60
None
0.76Aundetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1S14_A_NOVA1300_1
(TOPOISOMERASE IV
SUBUNIT B)		1ea6 PMS1 PROTEIN HOMOLOG
2
(Homo
sapiens)		5 / 12ASN A  45
SER A  46
ASP A  48
ASP A  70
THR A 155
 MG  A1365 ( 3.0A)
ADP  A1366 ( 3.9A)
None
ADP  A1366 (-3.4A)
ADP  A1366 ( 4.0A)
0.58A20.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1S14_A_NOVA1300_1
(TOPOISOMERASE IV
SUBUNIT B)		2ery RAS-RELATED PROTEIN
R-RAS2
(Homo
sapiens)		5 / 12ASP A 118
GLU A 119
MET A 122
PRO A 121
ILE A 111
None
1.42A21.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1S14_A_NOVA1300_1
(TOPOISOMERASE IV
SUBUNIT B)		2muo SECRETED
LY-6/UPAR-RELATED
PROTEIN 1
(Homo
sapiens)		5 / 12SER A 153
ASP A 125
MET A 129
ILE A 169
ARG A 149
None
1.20A14.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1S14_A_NOVA1300_1
(TOPOISOMERASE IV
SUBUNIT B)		2o49 DNA-BINDING PROTEIN
SATB1
(Homo
sapiens)		5 / 12ASP A 381
GLU A 382
ARG A 440
MET A 429
ILE A 375
None
1.18A22.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1S14_A_NOVA1300_1
(TOPOISOMERASE IV
SUBUNIT B)		3lvr ARF-GAP WITH SH3
DOMAIN, ANK REPEAT
AND PH
DOMAIN-CONTAINING
PROTEIN 3,
ADP-RIBOSYLATION
FACTOR 6
(Homo
sapiens;
synthetic
construct)		5 / 12GLU E 102
ARG E 105
PRO E  72
ILE E  70
ARG E  75
None
1.39A17.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1S14_A_NOVA1300_1
(TOPOISOMERASE IV
SUBUNIT B)		3r92 HEAT SHOCK PROTEIN
HSP 90-ALPHA
(Homo
sapiens)		5 / 12ASN A  51
SER A  52
ASP A  54
ASP A  93
THR A 184
06J  A   1 (-4.1A)
06J  A   1 ( 3.7A)
None
06J  A   1 (-3.5A)
06J  A   1 (-3.7A)
0.38A23.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1S14_A_NOVA1300_1
(TOPOISOMERASE IV
SUBUNIT B)		3r92 HEAT SHOCK PROTEIN
HSP 90-ALPHA
(Homo
sapiens)		6 / 12SER A  52
ASP A  54
ASP A  93
MET A  98
ASP A 156
THR A 184
06J  A   1 ( 3.7A)
None
06J  A   1 (-3.5A)
06J  A   1 (-3.7A)
None
06J  A   1 (-3.7A)
1.34A23.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1S14_A_NOVA1300_1
(TOPOISOMERASE IV
SUBUNIT B)		4raf PROTEIN PHOSPHATASE
1A
(Homo
sapiens)		5 / 12SER A 125
ASP A 199
ASP A 123
MET A 112
ILE A 108
None
1.10A18.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1S14_A_NOVA1300_1
(TOPOISOMERASE IV
SUBUNIT B)		5ofb MORC FAMILY CW-TYPE
ZINC FINGER PROTEIN
2
(Homo
sapiens)		5 / 12ASN B  39
ASP B  42
ASP B  68
MET B  73
THR B 197
 MG  B 703 ( 2.7A)
None
ATP  B 702 (-3.4A)
ATP  B 702 (-3.6A)
ATP  B 702 (-3.7A)
1.03A18.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1S14_A_NOVA1300_1
(TOPOISOMERASE IV
SUBUNIT B)		5ofb MORC FAMILY CW-TYPE
ZINC FINGER PROTEIN
2
(Homo
sapiens)		5 / 12ASN B 219
SER B 218
ASP B 215
ARG B  54
ILE B 257
None
1.47A18.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1S14_B_NOVB2300_1
(TOPOISOMERASE IV
SUBUNIT B)		1yse DNA-BINDING PROTEIN
SATB1
(Homo
sapiens)		5 / 12ASP A 381
GLU A 382
ARG A 440
MET A 429
ILE A 375
None
1.41A21.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1S14_B_NOVB2300_1
(TOPOISOMERASE IV
SUBUNIT B)		2o49 DNA-BINDING PROTEIN
SATB1
(Homo
sapiens)		5 / 12ASP A 381
GLU A 382
ARG A 440
MET A 429
ILE A 375
None
1.19A22.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1S14_B_NOVB2300_1
(TOPOISOMERASE IV
SUBUNIT B)		3lvr ARF-GAP WITH SH3
DOMAIN, ANK REPEAT
AND PH
DOMAIN-CONTAINING
PROTEIN 3,
ADP-RIBOSYLATION
FACTOR 6
(Homo
sapiens;
synthetic
construct)		5 / 12GLU E 102
ARG E 105
PRO E  72
ILE E  70
ARG E  75
None
1.41A17.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1S14_B_NOVB2300_1
(TOPOISOMERASE IV
SUBUNIT B)		3sog AMPHIPHYSIN
(Homo
sapiens)		5 / 12ASP A 108
GLU A 107
ASP A 103
ALA A  65
ILE A  67
None
K  A 238 ( 4.9A)
K  A 238 ( 3.6A)
None
None
1.22A24.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1S14_B_NOVB2300_1
(TOPOISOMERASE IV
SUBUNIT B)		4atm AMPHIPHYSIN
(Homo
sapiens)		5 / 12ASP A 108
GLU A 107
ASP A 103
ALA A  65
ILE A  67
None
1.24A22.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1S14_B_NOVB2300_1
(TOPOISOMERASE IV
SUBUNIT B)		4raf PROTEIN PHOSPHATASE
1A
(Homo
sapiens)		5 / 12SER A 125
ASP A 199
ASP A 123
MET A 112
ILE A 108
None
1.11A18.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1S14_B_NOVB2300_1
(TOPOISOMERASE IV
SUBUNIT B)		4uuk DYNAMIN-1
(Homo
sapiens)		5 / 12SER B 668
ASP B 667
ASP B 492
ALA B 408
ILE B 412
None
1.35A12.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1S14_B_NOVB2300_1
(TOPOISOMERASE IV
SUBUNIT B)		5mr4 GDNF FAMILY RECEPTOR
ALPHA-2
(Homo
sapiens)		5 / 12SER C 126
ASP C 270
ARG C 276
PRO C 286
ALA C 287
None
1.42A19.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1S14_B_NOVB2300_1
(TOPOISOMERASE IV
SUBUNIT B)		5ofb MORC FAMILY CW-TYPE
ZINC FINGER PROTEIN
2
(Homo
sapiens)		5 / 12ASN B 219
SER B 218
ASP B 215
ARG B  54
ILE B 257
None
1.43A18.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LPS_A_NOVA901_1
(TOPOISOMERASE IV
SUBUNIT B)		1ea6 PMS1 PROTEIN HOMOLOG
2
(Homo
sapiens)		5 / 12ASN A  45
SER A  46
ASP A  48
ASP A  70
THR A 155
 MG  A1365 ( 3.0A)
ADP  A1366 ( 3.9A)
None
ADP  A1366 (-3.4A)
ADP  A1366 ( 4.0A)
0.53A23.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LPS_A_NOVA901_1
(TOPOISOMERASE IV
SUBUNIT B)		2ery RAS-RELATED PROTEIN
R-RAS2
(Homo
sapiens)		5 / 12ASP A 118
GLU A 119
MET A 122
PRO A 121
ILE A 111
None
1.46A18.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LPS_A_NOVA901_1
(TOPOISOMERASE IV
SUBUNIT B)		2muo SECRETED
LY-6/UPAR-RELATED
PROTEIN 1
(Homo
sapiens)		5 / 12SER A 153
ASP A 125
MET A 129
ILE A 169
ARG A 149
None
1.24A12.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LPS_A_NOVA901_1
(TOPOISOMERASE IV
SUBUNIT B)		2p8e PPM1B BETA ISOFORM
VARIANT 6
(Homo
sapiens)		5 / 12SER A 130
ASP A 204
ASP A 128
MET A 117
ILE A 113
None
1.28A21.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LPS_A_NOVA901_1
(TOPOISOMERASE IV
SUBUNIT B)		3r92 HEAT SHOCK PROTEIN
HSP 90-ALPHA
(Homo
sapiens)		5 / 12ASN A  51
SER A  52
ASP A  54
ASP A  93
THR A 184
06J  A   1 (-4.1A)
06J  A   1 ( 3.7A)
None
06J  A   1 (-3.5A)
06J  A   1 (-3.7A)
0.34A19.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LPS_A_NOVA901_1
(TOPOISOMERASE IV
SUBUNIT B)		3r92 HEAT SHOCK PROTEIN
HSP 90-ALPHA
(Homo
sapiens)		5 / 12SER A  52
ASP A  54
ASP A  93
ASP A 156
THR A 184
06J  A   1 ( 3.7A)
None
06J  A   1 (-3.5A)
None
06J  A   1 (-3.7A)
1.20A19.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LPS_A_NOVA901_1
(TOPOISOMERASE IV
SUBUNIT B)		3r92 HEAT SHOCK PROTEIN
HSP 90-ALPHA
(Homo
sapiens)		5 / 12SER A  52
ASP A  54
ASP A  93
MET A  98
THR A 184
06J  A   1 ( 3.7A)
None
06J  A   1 (-3.5A)
06J  A   1 (-3.7A)
06J  A   1 (-3.7A)
0.67A19.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LPS_A_NOVA901_1
(TOPOISOMERASE IV
SUBUNIT B)		4raf PROTEIN PHOSPHATASE
1A
(Homo
sapiens)		5 / 12SER A 125
ASP A 199
ASP A 123
MET A 112
ILE A 108
None
1.10A20.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LPS_A_NOVA901_1
(TOPOISOMERASE IV
SUBUNIT B)		5do7 ATP-BINDING CASSETTE
SUB-FAMILY G MEMBER
5
(Homo
sapiens)		5 / 12ASP A 182
GLU A 146
ARG A 381
ILE A 193
THR A 147
None
1.50A20.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LPS_A_NOVA901_1
(TOPOISOMERASE IV
SUBUNIT B)		5ofb MORC FAMILY CW-TYPE
ZINC FINGER PROTEIN
2
(Homo
sapiens)		5 / 12ASN B  39
ASP B  42
ASP B  68
MET B  73
THR B 197
 MG  B 703 ( 2.7A)
None
ATP  B 702 (-3.4A)
ATP  B 702 (-3.6A)
ATP  B 702 (-3.7A)
0.92A15.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4URN_A_NOVA2000_1
(DNA TOPOISOMERASE
IV, B SUBUNIT)		1ea6 PMS1 PROTEIN HOMOLOG
2
(Homo
sapiens)		5 / 11ASN A  45
SER A  46
ASP A  48
ASP A  70
THR A 155
 MG  A1365 ( 3.0A)
ADP  A1366 ( 3.9A)
None
ADP  A1366 (-3.4A)
ADP  A1366 ( 4.0A)
0.44A20.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4URN_A_NOVA2000_1
(DNA TOPOISOMERASE
IV, B SUBUNIT)		1gri GROWTH FACTOR BOUND
PROTEIN 2
(Homo
sapiens)		5 / 11SER A  75
ASP A 104
GLU A  71
ARG A  67
ARG A  86
None
1.34A20.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4URN_A_NOVA2000_1
(DNA TOPOISOMERASE
IV, B SUBUNIT)		2muo SECRETED
LY-6/UPAR-RELATED
PROTEIN 1
(Homo
sapiens)		5 / 11SER A 153
ASP A 125
MET A 129
ILE A 169
ARG A 149
None
1.41A14.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4URN_A_NOVA2000_1
(DNA TOPOISOMERASE
IV, B SUBUNIT)		2nn6 POLYMYOSITIS/SCLEROD
ERMA AUTOANTIGEN 1
(Homo
sapiens)		5 / 11ASN A 144
GLU A 211
ASP A 142
ILE A 146
THR A  53
None
1.41A16.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4URN_A_NOVA2000_1
(DNA TOPOISOMERASE
IV, B SUBUNIT)		3r92 HEAT SHOCK PROTEIN
HSP 90-ALPHA
(Homo
sapiens)		5 / 11ASN A  51
SER A  52
ASP A  54
ASP A  93
THR A 184
06J  A   1 (-4.1A)
06J  A   1 ( 3.7A)
None
06J  A   1 (-3.5A)
06J  A   1 (-3.7A)
0.38A27.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4URN_A_NOVA2000_1
(DNA TOPOISOMERASE
IV, B SUBUNIT)		3r92 HEAT SHOCK PROTEIN
HSP 90-ALPHA
(Homo
sapiens)		5 / 11SER A  52
ASP A  54
ASP A  93
MET A  98
THR A 184
06J  A   1 ( 3.7A)
None
06J  A   1 (-3.5A)
06J  A   1 (-3.7A)
06J  A   1 (-3.7A)
0.68A27.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4URN_A_NOVA2000_1
(DNA TOPOISOMERASE
IV, B SUBUNIT)		4j8s CCR4-NOT
TRANSCRIPTION
COMPLEX SUBUNIT 1
(Homo
sapiens)		5 / 11ASN A 839
SER A 840
ASP A 836
GLU A 837
ARG A 873
None
1.32A19.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4URN_A_NOVA2000_1
(DNA TOPOISOMERASE
IV, B SUBUNIT)		5ofb MORC FAMILY CW-TYPE
ZINC FINGER PROTEIN
2
(Homo
sapiens)		5 / 11ASN B  39
ASP B  42
ASP B  68
MET B  73
THR B 197
 MG  B 703 ( 2.7A)
None
ATP  B 702 (-3.4A)
ATP  B 702 (-3.6A)
ATP  B 702 (-3.7A)
0.81A13.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4URN_B_NOVB2000_1
(DNA TOPOISOMERASE
IV, B SUBUNIT)		1ea6 PMS1 PROTEIN HOMOLOG
2
(Homo
sapiens)		5 / 11ASN A  45
SER A  46
ASP A  48
ASP A  70
THR A 155
 MG  A1365 ( 3.0A)
ADP  A1366 ( 3.9A)
None
ADP  A1366 (-3.4A)
ADP  A1366 ( 4.0A)
0.43A20.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4URN_B_NOVB2000_1
(DNA TOPOISOMERASE
IV, B SUBUNIT)		2muo SECRETED
LY-6/UPAR-RELATED
PROTEIN 1
(Homo
sapiens)		5 / 11SER A 153
ASP A 125
MET A 129
ILE A 169
ARG A 149
None
1.30A14.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4URN_B_NOVB2000_1
(DNA TOPOISOMERASE
IV, B SUBUNIT)		2nn6 POLYMYOSITIS/SCLEROD
ERMA AUTOANTIGEN 1
(Homo
sapiens)		5 / 11ASN A 144
GLU A 211
ASP A 142
ILE A 146
THR A  53
None
1.44A16.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4URN_B_NOVB2000_1
(DNA TOPOISOMERASE
IV, B SUBUNIT)		2p8e PPM1B BETA ISOFORM
VARIANT 6
(Homo
sapiens)		5 / 11SER A 130
ASP A 204
ASP A 128
MET A 117
ILE A 113
None
1.38A21.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4URN_B_NOVB2000_1
(DNA TOPOISOMERASE
IV, B SUBUNIT)		3r92 HEAT SHOCK PROTEIN
HSP 90-ALPHA
(Homo
sapiens)		5 / 11ASN A  51
SER A  52
ASP A  54
ASP A  93
THR A 184
06J  A   1 (-4.1A)
06J  A   1 ( 3.7A)
None
06J  A   1 (-3.5A)
06J  A   1 (-3.7A)
0.42A27.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4URN_B_NOVB2000_1
(DNA TOPOISOMERASE
IV, B SUBUNIT)		3r92 HEAT SHOCK PROTEIN
HSP 90-ALPHA
(Homo
sapiens)		5 / 11SER A  52
ASP A  54
ASP A  93
MET A  98
THR A 184
06J  A   1 ( 3.7A)
None
06J  A   1 (-3.5A)
06J  A   1 (-3.7A)
06J  A   1 (-3.7A)
0.71A27.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4URN_B_NOVB2000_1
(DNA TOPOISOMERASE
IV, B SUBUNIT)		4j8s CCR4-NOT
TRANSCRIPTION
COMPLEX SUBUNIT 1
(Homo
sapiens)		5 / 11ASN A 839
SER A 840
ASP A 836
GLU A 837
ARG A 873
None
1.43A19.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4URN_B_NOVB2000_1
(DNA TOPOISOMERASE
IV, B SUBUNIT)		4raf PROTEIN PHOSPHATASE
1A
(Homo
sapiens)		5 / 11SER A 125
ASP A 199
ASP A 123
MET A 112
ILE A 108
None
1.23A24.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4URN_C_NOVC2000_1
(DNA TOPOISOMERASE
IV, B SUBUNIT)		1ea6 PMS1 PROTEIN HOMOLOG
2
(Homo
sapiens)		5 / 11ASN A  45
SER A  46
ASP A  48
ASP A  70
THR A 155
 MG  A1365 ( 3.0A)
ADP  A1366 ( 3.9A)
None
ADP  A1366 (-3.4A)
ADP  A1366 ( 4.0A)
0.41A20.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4URN_C_NOVC2000_1
(DNA TOPOISOMERASE
IV, B SUBUNIT)		1gri GROWTH FACTOR BOUND
PROTEIN 2
(Homo
sapiens)		5 / 11SER A  75
ASP A 104
GLU A  71
ARG A  67
ARG A  86
None
1.41A20.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4URN_C_NOVC2000_1
(DNA TOPOISOMERASE
IV, B SUBUNIT)		2muo SECRETED
LY-6/UPAR-RELATED
PROTEIN 1
(Homo
sapiens)		5 / 11SER A 153
ASP A 125
MET A 129
ILE A 169
ARG A 149
None
1.27A14.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4URN_C_NOVC2000_1
(DNA TOPOISOMERASE
IV, B SUBUNIT)		2nn6 POLYMYOSITIS/SCLEROD
ERMA AUTOANTIGEN 1
(Homo
sapiens)		5 / 11ASN A 144
GLU A 211
ASP A 142
ILE A 146
THR A  53
None
1.43A16.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4URN_C_NOVC2000_1
(DNA TOPOISOMERASE
IV, B SUBUNIT)		2o49 DNA-BINDING PROTEIN
SATB1
(Homo
sapiens)		5 / 11ASP A 381
GLU A 382
ARG A 440
MET A 429
ILE A 375
None
1.10A18.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4URN_C_NOVC2000_1
(DNA TOPOISOMERASE
IV, B SUBUNIT)		2p8e PPM1B BETA ISOFORM
VARIANT 6
(Homo
sapiens)		5 / 11SER A 130
ASP A 204
ASP A 128
MET A 117
ILE A 113
None
1.41A21.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4URN_C_NOVC2000_1
(DNA TOPOISOMERASE
IV, B SUBUNIT)		3r92 HEAT SHOCK PROTEIN
HSP 90-ALPHA
(Homo
sapiens)		5 / 11ASN A  51
SER A  52
ASP A  54
ASP A  93
THR A 184
06J  A   1 (-4.1A)
06J  A   1 ( 3.7A)
None
06J  A   1 (-3.5A)
06J  A   1 (-3.7A)
0.37A27.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4URN_C_NOVC2000_1
(DNA TOPOISOMERASE
IV, B SUBUNIT)		3r92 HEAT SHOCK PROTEIN
HSP 90-ALPHA
(Homo
sapiens)		5 / 11SER A  52
ASP A  54
ASP A  93
MET A  98
THR A 184
06J  A   1 ( 3.7A)
None
06J  A   1 (-3.5A)
06J  A   1 (-3.7A)
06J  A   1 (-3.7A)
0.68A27.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4URN_C_NOVC2000_1
(DNA TOPOISOMERASE
IV, B SUBUNIT)		4j8s CCR4-NOT
TRANSCRIPTION
COMPLEX SUBUNIT 1
(Homo
sapiens)		5 / 11ASN A 839
SER A 840
ASP A 836
GLU A 837
ARG A 873
None
1.41A19.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4URN_C_NOVC2000_1
(DNA TOPOISOMERASE
IV, B SUBUNIT)		5ofb MORC FAMILY CW-TYPE
ZINC FINGER PROTEIN
2
(Homo
sapiens)		5 / 11ASN B  39
ASP B  42
ASP B  68
MET B  73
THR B 197
 MG  B 703 ( 2.7A)
None
ATP  B 702 (-3.4A)
ATP  B 702 (-3.6A)
ATP  B 702 (-3.7A)
0.91A13.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4URN_C_NOVC2000_1
(DNA TOPOISOMERASE
IV, B SUBUNIT)		6c3p ATP-BINDING CASSETTE
SUB-FAMILY C MEMBER
8
(Homo
sapiens)		5 / 11SER E1125
ASP E1127
ARG E 526
ILE E1104
THR E 499
None
1.42A15.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4URO_A_NOVA2000_1
(DNA GYRASE SUBUNIT B)		1htr GASTRICSIN
(Homo
sapiens)		5 / 12SER B 314
ARG B 322
ILE B 193
PRO B 184
ILE B 264
None
1.36A22.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4URO_A_NOVA2000_1
(DNA GYRASE SUBUNIT B)		1q3x MANNAN-BINDING
LECTIN SERINE
PROTEASE 2
(Homo
sapiens)		5 / 12GLU A 413
ASP A 415
ASP A 407
GLN A 393
ILE A 392
None
1.19A18.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4URO_A_NOVA2000_1
(DNA GYRASE SUBUNIT B)		1zjk MANNAN-BINDING
LECTIN SERINE
PROTEASE 2
(Homo
sapiens)		5 / 12GLU A 413
ASP A 415
ASP A 407
GLN A 393
ILE A 392
None
1.12A20.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4URO_A_NOVA2000_1
(DNA GYRASE SUBUNIT B)		3j2i PROLIFERATION-ASSOCI
ATED PROTEIN 2G4
(Homo
sapiens)		5 / 12SER A  47
ILE A  80
GLN A 318
ILE A 108
SER A  39
None
1.37A21.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4URO_A_NOVA2000_1
(DNA GYRASE SUBUNIT B)		4bpx DNA POLYMERASE ALPHA
CATALYTIC SUBUNIT,
DNA PRIMASE LARGE
SUBUNIT
(Homo
sapiens)		5 / 12ASP B 193
GLN B 123
ILE B 121
SER B 227
ARG B 129
None
1.35A20.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4URO_A_NOVA2000_1
(DNA GYRASE SUBUNIT B)		4da5 CHOLINE KINASE ALPHA
(Homo
sapiens)		5 / 12GLU A 206
ILE A 329
ASP A 306
GLN A 308
SER A 211
None
None
0H7  A 502 (-3.1A)
0H7  A 502 (-3.1A)
None
0.99A18.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4URO_A_NOVA2000_1
(DNA GYRASE SUBUNIT B)		4f52 GLOMULIN
(Homo
sapiens)		5 / 12ASP E 235
ILE E 298
ASP E 301
GLN E 302
ILE E 245
None
1.25A17.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4URO_A_NOVA2000_1
(DNA GYRASE SUBUNIT B)		4fxg MANNAN-BINDING
LECTIN SERINE
PROTEASE 2 A CHAIN
(Homo
sapiens)		5 / 12GLU G 413
ASP G 415
ASP G 407
GLN G 393
ILE G 392
None
1.08A18.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4URO_A_NOVA2000_1
(DNA GYRASE SUBUNIT B)		4hqp ALPHA7 NICOTINIC
RECEPTOR CHIMERA
(Homo
sapiens;
Lymnaea
stagnalis)		5 / 12SER A 144
ASP A  87
ILE A  19
PRO A  20
GLN A  22
None
1.13A22.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4URO_A_NOVA2000_1
(DNA GYRASE SUBUNIT B)		5dj4 SESTRIN-2
(Homo
sapiens)		5 / 12ASN A 163
SER A 160
GLU A 161
ASP A 325
GLN A 332
None
1.37A19.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4URO_A_NOVA2000_1
(DNA GYRASE SUBUNIT B)		5ftg CHOLINE KINASE ALPHA
(Homo
sapiens)		5 / 12GLU A 206
ILE A 329
ASP A 306
GLN A 308
SER A 211
None
None
EDO  A1466 ( 3.0A)
NBR  A1458 ( 3.3A)
None
0.87A22.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4URO_A_NOVA2000_1
(DNA GYRASE SUBUNIT B)		5gve DNA TOPOISOMERASE
3-BETA-1
(Homo
sapiens)		5 / 12GLU A 565
ARG A 181
ILE A 514
GLN A 319
ILE A 518
None
1.33A16.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4URO_A_NOVA2000_1
(DNA GYRASE SUBUNIT B)		5uhk O-GLCNACASE
TIM-BARREL DOMAIN
(Homo
sapiens)		5 / 12ASN A 147
SER A 146
ASP A 184
ILE A 143
PRO A 139
None
1.36A21.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4URO_A_NOVA2000_1
(DNA GYRASE SUBUNIT B)		5uhp O-GLCNACASE
TIM-BARREL DOMAIN
(Homo
sapiens)		5 / 12ASN A 147
SER A 146
ASP A 184
ILE A 143
PRO A 139
None
1.36A20.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4URO_A_NOVA2000_1
(DNA GYRASE SUBUNIT B)		5vvo PROTEIN O-GLCNACASE
(Homo
sapiens)		5 / 12ASN A 147
SER A 146
ASP A 184
ILE A 143
PRO A 139
None
1.36A19.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4URO_B_NOVB2000_1
(DNA GYRASE SUBUNIT B)		1zjk MANNAN-BINDING
LECTIN SERINE
PROTEASE 2
(Homo
sapiens)		5 / 12GLU A 413
ASP A 415
ASP A 407
GLN A 393
ILE A 392
None
1.14A20.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4URO_B_NOVB2000_1
(DNA GYRASE SUBUNIT B)		2dks CARCINOEMBRYONIC
ANTIGEN-RELATED CELL
ADHESION MOLECULE 8
(Homo
sapiens)		5 / 12ASN A  72
SER A  71
ILE A  55
GLN A  63
ARG A  53
None
1.37A20.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4URO_B_NOVB2000_1
(DNA GYRASE SUBUNIT B)		3j2i PROLIFERATION-ASSOCI
ATED PROTEIN 2G4
(Homo
sapiens)		5 / 12ASP A  97
ARG A 281
ILE A  80
ILE A 108
SER A  39
None
1.34A21.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4URO_B_NOVB2000_1
(DNA GYRASE SUBUNIT B)		3j2i PROLIFERATION-ASSOCI
ATED PROTEIN 2G4
(Homo
sapiens)		5 / 12SER A  47
ILE A  80
GLN A 318
ILE A 108
SER A  39
None
1.38A21.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4URO_B_NOVB2000_1
(DNA GYRASE SUBUNIT B)		4cnt DIHYDROPYRIMIDINASE-
LIKE 3
(Homo
sapiens)		5 / 12SER A 407
ILE A 401
ASP A  28
GLN A  29
ILE A  24
None
1.32A19.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4URO_B_NOVB2000_1
(DNA GYRASE SUBUNIT B)		4da5 CHOLINE KINASE ALPHA
(Homo
sapiens)		5 / 12GLU A 206
ILE A 329
ASP A 306
GLN A 308
SER A 211
None
None
0H7  A 502 (-3.1A)
0H7  A 502 (-3.1A)
None
1.13A18.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4URO_B_NOVB2000_1
(DNA GYRASE SUBUNIT B)		4f52 GLOMULIN
(Homo
sapiens)		5 / 12ASP E 235
ILE E 298
ASP E 301
GLN E 302
ILE E 245
None
1.29A17.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4URO_B_NOVB2000_1
(DNA GYRASE SUBUNIT B)		4hqp ALPHA7 NICOTINIC
RECEPTOR CHIMERA
(Homo
sapiens;
Lymnaea
stagnalis)		5 / 12SER A 144
ASP A  87
ILE A  19
PRO A  20
GLN A  22
None
1.15A22.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4URO_B_NOVB2000_1
(DNA GYRASE SUBUNIT B)		4yj5 PYRUVATE KINASE PKM
(Homo
sapiens)		5 / 12GLU A 253
ILE A 245
ILE A 283
SER A 287
ARG A 246
None
1.31A19.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4URO_B_NOVB2000_1
(DNA GYRASE SUBUNIT B)		5dj4 SESTRIN-2
(Homo
sapiens)		5 / 12ASN A 163
SER A 160
GLU A 161
ASP A 325
GLN A 332
None
1.31A19.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4URO_B_NOVB2000_1
(DNA GYRASE SUBUNIT B)		5ftg CHOLINE KINASE ALPHA
(Homo
sapiens)		5 / 12GLU A 206
ILE A 329
ASP A 306
GLN A 308
SER A 211
None
None
EDO  A1466 ( 3.0A)
NBR  A1458 ( 3.3A)
None
0.99A22.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4URO_B_NOVB2000_1
(DNA GYRASE SUBUNIT B)		5iy9 DNA-DIRECTED RNA
POLYMERASE II
SUBUNIT RPB1
(Homo
sapiens)		5 / 12ASN A 945
SER A 944
ARG A 932
PRO A1006
ILE A1007
None
0.98A8.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4URO_B_NOVB2000_1
(DNA GYRASE SUBUNIT B)		5l7d SMOOTHENED
HOMOLOG,SOLUBLE
CYTOCHROME
B562,SMOOTHENED
HOMOLOG
(Escherichia
coli;
Homo
sapiens)		5 / 12SER A  96
ASP A  95
ASP A 172
SER A  89
ARG A 173
None
CLR  A1203 (-3.7A)
None
None
None
1.15A16.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4URO_B_NOVB2000_1
(DNA GYRASE SUBUNIT B)		5uhp O-GLCNACASE
TIM-BARREL DOMAIN
(Homo
sapiens)		5 / 12ASN A 147
SER A 146
ASP A 184
ILE A 143
PRO A 139
None
1.38A20.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4URO_B_NOVB2000_1
(DNA GYRASE SUBUNIT B)		5v57 SMOOTHENED
HOMOLOG,FLAVODOXIN,S
MOOTHENED HOMOLOG
(Desulfovibrio
vulgaris;
Homo
sapiens)		5 / 12SER A  96
ASP A  95
ASP A 172
SER A  89
ARG A 173
None
1.16A15.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4URO_B_NOVB2000_1
(DNA GYRASE SUBUNIT B)		5vvo PROTEIN O-GLCNACASE
(Homo
sapiens)		5 / 12ASN A 147
SER A 146
ASP A 184
ILE A 143
PRO A 139
None
1.38A19.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4URO_C_NOVC2000_1
(DNA GYRASE SUBUNIT B)		1f59 IMPORTIN BETA-1
(Homo
sapiens)		5 / 12ASP A 168
ILE A 121
PRO A 122
GLN A  77
ILE A 161
None
1.30A17.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4URO_C_NOVC2000_1
(DNA GYRASE SUBUNIT B)		1kqo NICOTINAMIDE
MONONUCLEOTIDE
ADENYLYL TRANSFERASE
(Homo
sapiens)		5 / 12ASN A  22
ILE A 226
GLN A 234
ALA A 229
ILE A 236
None
0.99A20.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4URO_C_NOVC2000_1
(DNA GYRASE SUBUNIT B)		3ehq OSTEOCLAST-STIMULATI
NG FACTOR 1
(Homo
sapiens)		5 / 12ILE A  61
PRO A  62
GLN A  69
ILE A  33
SER A  54
None
1.28A24.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4URO_C_NOVC2000_1
(DNA GYRASE SUBUNIT B)		3tac LIPRIN-ALPHA-2
(Homo
sapiens)		5 / 12ARG B1112
ILE B1114
ALA B1126
ILE B1129
SER B1132
None
1.30A23.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4URO_C_NOVC2000_1
(DNA GYRASE SUBUNIT B)		4da5 CHOLINE KINASE ALPHA
(Homo
sapiens)		5 / 12GLU A 206
ILE A 329
ASP A 306
GLN A 308
SER A 211
None
None
0H7  A 502 (-3.1A)
0H7  A 502 (-3.1A)
None
1.06A18.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4URO_C_NOVC2000_1
(DNA GYRASE SUBUNIT B)		4rew 5'-AMP-ACTIVATED
PROTEIN KINASE
CATALYTIC SUBUNIT
ALPHA-1
(Homo
sapiens)		5 / 12ARG A 265
ILE A 264
ALA A 259
ILE A 199
SER A 202
None
1.19A17.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4URO_C_NOVC2000_1
(DNA GYRASE SUBUNIT B)		5ftg CHOLINE KINASE ALPHA
(Homo
sapiens)		5 / 12GLU A 206
ILE A 329
ASP A 306
GLN A 308
SER A 211
None
None
EDO  A1466 ( 3.0A)
NBR  A1458 ( 3.3A)
None
0.91A22.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4URO_C_NOVC2000_1
(DNA GYRASE SUBUNIT B)		5ivw GENERAL
TRANSCRIPTION FACTOR
IIH SUBUNIT 3
(Homo
sapiens)		5 / 12ASP 3 169
ILE 3 181
GLN 3 187
ALA 3 184
ILE 3 191
None
1.14A22.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4URO_C_NOVC2000_1
(DNA GYRASE SUBUNIT B)		5kel C2G4 VARIABLE FAB
DOMAIN HEAVY CHAIN
(Homo
sapiens)		5 / 12ASP H  73
ARG H  94
ILE H  51
ALA H  49
ILE H  69
None
1.23A19.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4URO_C_NOVC2000_1
(DNA GYRASE SUBUNIT B)		5xbk IMPORTIN-4
(Homo
sapiens)		5 / 12GLU D 914
ASP D 912
ARG D 956
GLN D 887
ALA D 883
None
1.29A15.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4URO_C_NOVC2000_1
(DNA GYRASE SUBUNIT B)		6coy CHLORIDE CHANNEL
PROTEIN 1
(Homo
sapiens)		5 / 12ILE A 479
PRO A 478
ALA A 176
ILE A 172
SER A 225
None
1.08A12.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4URO_D_NOVD2000_1
(DNA GYRASE SUBUNIT B)		2nn6 POLYMYOSITIS/SCLEROD
ERMA AUTOANTIGEN 1
(Homo
sapiens)		5 / 12GLU A 211
ASP A 142
ILE A 145
ILE A 146
THR A  53
None
1.38A19.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4URO_D_NOVD2000_1
(DNA GYRASE SUBUNIT B)		3j2i PROLIFERATION-ASSOCI
ATED PROTEIN 2G4
(Homo
sapiens)		5 / 12ASP A  97
ARG A 281
ILE A  80
ILE A 108
SER A  39
None
1.38A21.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4URO_D_NOVD2000_1
(DNA GYRASE SUBUNIT B)		4oe5 DELTA-1-PYRROLINE-5-
CARBOXYLATE
DEHYDROGENASE,
MITOCHONDRIAL
(Homo
sapiens)		5 / 12SER A 331
GLU A 330
ASP A 328
ARG A 367
ILE A 364
None
1.35A18.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4URO_D_NOVD2000_1
(DNA GYRASE SUBUNIT B)		5uhk O-GLCNACASE
TIM-BARREL DOMAIN
(Homo
sapiens)		5 / 12ASN A 147
SER A 146
ASP A 184
ILE A 143
PRO A 139
None
1.38A21.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4URO_D_NOVD2000_1
(DNA GYRASE SUBUNIT B)		5uhp O-GLCNACASE
TIM-BARREL DOMAIN
(Homo
sapiens)		5 / 12ASN A 147
SER A 146
ASP A 184
ILE A 143
PRO A 139
None
1.36A20.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4URO_D_NOVD2000_1
(DNA GYRASE SUBUNIT B)		5vvo PROTEIN O-GLCNACASE
(Homo
sapiens)		5 / 12ASN A 147
SER A 146
ASP A 184
ILE A 143
PRO A 139
None
1.37A19.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4URO_D_NOVD2000_1
(DNA GYRASE SUBUNIT B)		6avg T-CELL RECEPTOR
ALPHA VARIABLE 4,TCR
ALPHA CHAIN
(Homo
sapiens)		5 / 12SER C  64
ILE C  67
PRO C  68
ASP C  70
ILE C  36
None
0.97A15.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6B89_A_NOVA403_1
(LIPOPOLYSACCHARIDE
EXPORT SYSTEM
ATP-BINDING PROTEIN
LPTB)		1gjj LAP2
(Homo
sapiens)		5 / 10LEU A  20
TYR A  41
PRO A   8
GLU A 114
SER A   9
None
1.43A19.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6B89_A_NOVA403_1
(LIPOPOLYSACCHARIDE
EXPORT SYSTEM
ATP-BINDING PROTEIN
LPTB)		4i6f SERINE/THREONINE-PRO
TEIN KINASE PLK2
(Homo
sapiens)		5 / 10LEU A 303
ALA A 307
TYR A 271
PRO A 279
GLU A 281
None
1.49A14.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6B89_A_NOVA403_1
(LIPOPOLYSACCHARIDE
EXPORT SYSTEM
ATP-BINDING PROTEIN
LPTB)		5exr DNA POLYMERASE ALPHA
SUBUNIT B
(Homo
sapiens)		5 / 10ALA D 529
TYR D 509
PRO D 514
GLU D 516
VAL D 219
None
1.29A10.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6B89_A_NOVA403_2
(LIPOPOLYSACCHARIDE
EXPORT SYSTEM
ATP-BINDING PROTEIN
LPTB)		1m9q ENDOTHELIAL
NITRIC-OXIDE
SYNTHASE
(Homo
sapiens)		4 / 6PHE A 231
ARG A 242
ALA A 198
GLN A 294
None
1.08A15.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6B89_A_NOVA403_2
(LIPOPOLYSACCHARIDE
EXPORT SYSTEM
ATP-BINDING PROTEIN
LPTB)		1n0w DNA REPAIR PROTEIN
RAD51 HOMOLOG 1
(Homo
sapiens)		4 / 6PHE A 248
ARG A 247
LEU A 249
ALA A 224
None
None
EDO  A 503 (-4.7A)
None
1.05A15.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6B89_A_NOVA403_2
(LIPOPOLYSACCHARIDE
EXPORT SYSTEM
ATP-BINDING PROTEIN
LPTB)		2yb6 UBIQUITIN-CONJUGATIN
G ENZYME E2 B
(Homo
sapiens)		4 / 6ARG A   8
ARG A  15
LEU A  16
ALA A  38
None
1.06A22.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6B89_A_NOVA403_2
(LIPOPOLYSACCHARIDE
EXPORT SYSTEM
ATP-BINDING PROTEIN
LPTB)		3bs9 NUCLEOLYSIN TIA-1
ISOFORM P40
(Homo
sapiens)		4 / 6ARG A 164
LEU A 161
ALA A 110
GLN A 165
None
0.94A24.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6B89_A_NOVA403_2
(LIPOPOLYSACCHARIDE
EXPORT SYSTEM
ATP-BINDING PROTEIN
LPTB)		3bxw CHITINASE
DOMAIN-CONTAINING
PROTEIN 1
(Homo
sapiens)		4 / 6PHE B  55
LEU B 345
ALA B 348
GLN B  24
None
1.04A12.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6B89_A_NOVA403_2
(LIPOPOLYSACCHARIDE
EXPORT SYSTEM
ATP-BINDING PROTEIN
LPTB)		3e7g NITRIC OXIDE
SYNTHASE, INDUCIBLE
(Homo
sapiens)		4 / 6PHE A 247
ARG A 258
ALA A 214
GLN A 310
None
1.03A10.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6B89_A_NOVA403_2
(LIPOPOLYSACCHARIDE
EXPORT SYSTEM
ATP-BINDING PROTEIN
LPTB)		3orh GUANIDINOACETATE
N-METHYLTRANSFERASE
(Homo
sapiens)		4 / 6ARG A 100
LEU A  99
ALA A  75
GLN A  97
None
0.96A15.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6B89_A_NOVA403_2
(LIPOPOLYSACCHARIDE
EXPORT SYSTEM
ATP-BINDING PROTEIN
LPTB)		3pv6 NATURAL CYTOTOXICITY
TRIGGERING RECEPTOR
3
(Homo
sapiens)		4 / 6PHE B  41
ARG B 109
LEU B  19
ALA B  43
None
1.01A17.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6B89_A_NOVA403_2
(LIPOPOLYSACCHARIDE
EXPORT SYSTEM
ATP-BINDING PROTEIN
LPTB)		3uem PROTEIN
DISULFIDE-ISOMERASE
(Homo
sapiens)		4 / 6PHE A 377
LEU A 372
ALA A 381
GLN A 358
None
0.99A13.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6B89_A_NOVA403_2
(LIPOPOLYSACCHARIDE
EXPORT SYSTEM
ATP-BINDING PROTEIN
LPTB)		4el1 PROTEIN
DISULFIDE-ISOMERASE
(Homo
sapiens)		4 / 6PHE A 377
LEU A 372
ALA A 381
GLN A 358
None
1.04A11.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6B89_A_NOVA403_2
(LIPOPOLYSACCHARIDE
EXPORT SYSTEM
ATP-BINDING PROTEIN
LPTB)		4f99 CELL DIVISION CYCLE
7-RELATED PROTEIN
KINASE
(Homo
sapiens)		4 / 6PHE A 162
LEU A 165
ALA A 400
GLN A 170
None
1.01A13.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6B89_A_NOVA403_2
(LIPOPOLYSACCHARIDE
EXPORT SYSTEM
ATP-BINDING PROTEIN
LPTB)		4rdu HOMEOBOX PROTEIN
DLX-5
(Homo
sapiens)		4 / 6ARG A 167
LEU A 170
ALA A 151
GLN A 178
None
1.07A18.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6B89_A_NOVA403_2
(LIPOPOLYSACCHARIDE
EXPORT SYSTEM
ATP-BINDING PROTEIN
LPTB)		4ui9 CELL DIVISION CYCLE
PROTEIN 23 HOMOLOG
(Homo
sapiens)		4 / 6PHE C 513
ARG C 514
LEU C 516
GLN C 518
None
1.08A9.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6B89_A_NOVA403_2
(LIPOPOLYSACCHARIDE
EXPORT SYSTEM
ATP-BINDING PROTEIN
LPTB)		4wn5 HYPOXIA-INDUCIBLE
FACTOR 3-ALPHA
(Homo
sapiens)		4 / 6PHE A 306
ARG A 305
LEU A 314
ALA A 262
MVC  A 402 (-2.8A)
None
None
None
1.03A23.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6B89_A_NOVA403_2
(LIPOPOLYSACCHARIDE
EXPORT SYSTEM
ATP-BINDING PROTEIN
LPTB)		5aga DNA POLYMERASE THETA
(Homo
sapiens)		4 / 6ARG A 521
LEU A 519
ALA A 534
GLN A 520
None
0.99A7.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6B89_A_NOVA403_2
(LIPOPOLYSACCHARIDE
EXPORT SYSTEM
ATP-BINDING PROTEIN
LPTB)		5ci7 SERINE/THREONINE-PRO
TEIN KINASE ULK1
(Homo
sapiens)		4 / 6PHE A 232
ARG A 230
LEU A 229
GLN A 227
None
0.62A14.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6B89_A_NOVA403_2
(LIPOPOLYSACCHARIDE
EXPORT SYSTEM
ATP-BINDING PROTEIN
LPTB)		5hly INHIBIN BETA A CHAIN
(Homo
sapiens)		4 / 6ARG A 229
LEU A 231
ALA A 297
GLN A 233
None
1.01A14.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6B89_A_NOVA403_2
(LIPOPOLYSACCHARIDE
EXPORT SYSTEM
ATP-BINDING PROTEIN
LPTB)		6fn1 HUMAN-MOUSE CHIMERIC
ABCB1 (ABCBHM)
(Homo
sapiens)		4 / 6ARG A 542
ARG A 546
LEU A 544
ALA A 571
None
0.91A18.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6B89_B_NOVB403_1
(LIPOPOLYSACCHARIDE
EXPORT SYSTEM
ATP-BINDING PROTEIN
LPTB)		1ef1 MOESIN
(Homo
sapiens)		4 / 7PHE A  45
ARG A  81
GLN A  95
GLN A  48
None
None
SO4  A2001 (-3.8A)
None
1.28A14.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6B89_B_NOVB403_1
(LIPOPOLYSACCHARIDE
EXPORT SYSTEM
ATP-BINDING PROTEIN
LPTB)		1n0w DNA REPAIR PROTEIN
RAD51 HOMOLOG 1
(Homo
sapiens)		4 / 7PHE A 248
ARG A 247
LEU A 249
ALA A 224
None
None
EDO  A 503 (-4.7A)
None
1.12A15.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6B89_B_NOVB403_1
(LIPOPOLYSACCHARIDE
EXPORT SYSTEM
ATP-BINDING PROTEIN
LPTB)		2a1r POLY(A)-SPECIFIC
RIBONUCLEASE PARN
(Homo
sapiens)		4 / 7PHE A  88
LEU A  71
ALA A  18
GLN A  68
None
1.16A13.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6B89_B_NOVB403_1
(LIPOPOLYSACCHARIDE
EXPORT SYSTEM
ATP-BINDING PROTEIN
LPTB)		2jrs RNA-BINDING PROTEIN
39
(Homo
sapiens)		4 / 7PHE A  75
ARG A  28
ALA A  84
GLN A  57
PHE  A  75 ( 1.3A)
ARG  A  28 ( 0.6A)
ALA  A  84 ( 0.0A)
GLN  A  57 ( 0.6A)
1.31A25.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6B89_B_NOVB403_1
(LIPOPOLYSACCHARIDE
EXPORT SYSTEM
ATP-BINDING PROTEIN
LPTB)		3a6p EXPORTIN-5
(Homo
sapiens)		4 / 7PHE A 359
ARG A 368
LEU A 367
GLN A 372
None
1.26A5.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6B89_B_NOVB403_1
(LIPOPOLYSACCHARIDE
EXPORT SYSTEM
ATP-BINDING PROTEIN
LPTB)		3d1n POU DOMAIN, CLASS 6,
TRANSCRIPTION FACTOR
1
(Homo
sapiens)		4 / 7PHE I 226
ALA I 171
GLN I 170
GLN I 217
None
1.25A16.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6B89_B_NOVB403_1
(LIPOPOLYSACCHARIDE
EXPORT SYSTEM
ATP-BINDING PROTEIN
LPTB)		3kyo MHC CLASS I ANTIGEN
(Homo
sapiens)		4 / 7PHE A  36
ALA A  71
GLN A  72
GLN A  32
None
1.30A10.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6B89_B_NOVB403_1
(LIPOPOLYSACCHARIDE
EXPORT SYSTEM
ATP-BINDING PROTEIN
LPTB)		3kzz SNAP-TAG
(Homo
sapiens)		4 / 7LEU A 117
ALA A 121
GLN A  97
GLN A 150
None
1.01A16.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6B89_B_NOVB403_1
(LIPOPOLYSACCHARIDE
EXPORT SYSTEM
ATP-BINDING PROTEIN
LPTB)		3mpx FYVE, RHOGEF AND PH
DOMAIN-CONTAINING
PROTEIN 5
(Homo
sapiens)		4 / 7PHE A1044
ARG A1042
LEU A1043
ALA A1081
None
1.29A14.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6B89_B_NOVB403_1
(LIPOPOLYSACCHARIDE
EXPORT SYSTEM
ATP-BINDING PROTEIN
LPTB)		3ut3 PLASMINOGEN
ACTIVATOR INHIBITOR
1
(Homo
sapiens)		4 / 7PHE A 117
ARG A 118
ALA A  44
GLN A  47
None
1.27A11.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6B89_B_NOVB403_1
(LIPOPOLYSACCHARIDE
EXPORT SYSTEM
ATP-BINDING PROTEIN
LPTB)		4lcy HLA CLASS I
HISTOCOMPATIBILITY
ANTIGEN, B-46 ALPHA
CHAIN
(Homo
sapiens)		4 / 7PHE A  36
ARG A  35
ALA A  71
GLN A  72
None
1.08A13.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6B89_B_NOVB403_1
(LIPOPOLYSACCHARIDE
EXPORT SYSTEM
ATP-BINDING PROTEIN
LPTB)		4rh7 GREEN FLUORESCENT
PROTEIN/CYTOPLASMIC
DYNEIN 2 HEAVY CHAIN
1
(Homo
sapiens;
synthetic
construct)		4 / 7PHE A3527
ARG A3529
ALA A3499
GLN A3532
None
1.29A2.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6B89_B_NOVB403_1
(LIPOPOLYSACCHARIDE
EXPORT SYSTEM
ATP-BINDING PROTEIN
LPTB)		5hcc COMPLEMENT C5
(Homo
sapiens)		4 / 7PHE B 646
ARG B 539
LEU B 651
GLN B  42
None
1.30A10.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6B89_B_NOVB403_1
(LIPOPOLYSACCHARIDE
EXPORT SYSTEM
ATP-BINDING PROTEIN
LPTB)		5mvx DELTA-LIKE PROTEIN 4
(Homo
sapiens)		4 / 7PHE A  37
ARG A 166
ARG A 168
ALA A 121
None
1.31A14.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6B89_B_NOVB403_1
(LIPOPOLYSACCHARIDE
EXPORT SYSTEM
ATP-BINDING PROTEIN
LPTB)		5mvx DELTA-LIKE PROTEIN 4
(Homo
sapiens)		4 / 7PHE A  37
ARG A 168
LEU A 167
ALA A 121
None
1.11A14.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6B89_B_NOVB403_1
(LIPOPOLYSACCHARIDE
EXPORT SYSTEM
ATP-BINDING PROTEIN
LPTB)		5tf2 PROLACTIN REGULATORY
ELEMENT-BINDING
PROTEIN
(Homo
sapiens)		4 / 7ARG A  94
LEU A  93
ALA A  84
GLN A  96
None
1.26A13.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6B89_B_NOVB403_2
(LIPOPOLYSACCHARIDE
EXPORT SYSTEM
ATP-BINDING PROTEIN
LPTB)		3e3b CASEIN KINASE II
SUBUNIT ALPHA'
(Homo
sapiens)		5 / 10LEU X 305
ALA X 319
GLU X 283
SER X 295
ARG X 135
None
1.48A11.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6B89_B_NOVB403_2
(LIPOPOLYSACCHARIDE
EXPORT SYSTEM
ATP-BINDING PROTEIN
LPTB)		3fed GLUTAMATE
CARBOXYPEPTIDASE III
(Homo
sapiens)		5 / 10LEU A 661
ALA A 633
PRO A 458
PHE A 695
VAL A 626
None
1.35A8.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6B89_B_NOVB403_2
(LIPOPOLYSACCHARIDE
EXPORT SYSTEM
ATP-BINDING PROTEIN
LPTB)		4twe N-ACETYLATED-ALPHA-L
INKED ACIDIC
DIPEPTIDASE-LIKE
PROTEIN
(Homo
sapiens)		5 / 10LEU A 662
ALA A 632
PRO A 460
PHE A 693
VAL A 625
None
1.47A7.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6B89_B_NOVB403_2
(LIPOPOLYSACCHARIDE
EXPORT SYSTEM
ATP-BINDING PROTEIN
LPTB)		5dot CARBAMOYL-PHOSPHATE
SYNTHASE [AMMONIA],
MITOCHONDRIAL
(Homo
sapiens)		5 / 10LEU A1208
HIS A1195
PRO A1311
SER A1331
VAL A1201
None
1.44A5.10