POTENTIAL TARGETS FROM HUMAN (RESULTS FROM SUB-STRUCTURAL SIMILARITY SEARCHES)
1) User may click on the DrReposER ID (the second column) to get information on the binding sites and drug molecule.
2) Click View (the second last column) to view matched residues and superposition in the NGL viewer (upper right part).
3) User may also click on the Dock (the last column) to get script for molecular docking in UCSF Chimera through AutoDock Vina.

DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YKI_A_NFZA1219_1
(OXYGEN-INSENSITIVE
NAD(P)H
NITROREDUCTASE)		1h4r MERLIN
(Homo
sapiens)		4 / 8PHE A  61
GLY A  63
THR A  28
PHE A  96
None
1.08A23.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YKI_A_NFZA1219_1
(OXYGEN-INSENSITIVE
NAD(P)H
NITROREDUCTASE)		2o6l UDP-GLUCURONOSYLTRAN
SFERASE 2B7
(Homo
sapiens)		4 / 8TYR A 438
ASN A 441
LYS A 444
GLY A 410
None
0.92A21.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YKI_A_NFZA1219_1
(OXYGEN-INSENSITIVE
NAD(P)H
NITROREDUCTASE)		2y23 MYOMESIN
(Homo
sapiens)		4 / 8PHE A1418
ASN A1373
GLU A1371
GLY A1370
None
1.05A23.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YKI_A_NFZA1219_1
(OXYGEN-INSENSITIVE
NAD(P)H
NITROREDUCTASE)		3j8f POLIOVIRUS RECEPTOR
(Homo
sapiens)		4 / 8TYR 7 121
ASN 7 120
GLU 7 118
GLY 7 119
None
NAG  7 504 ( 1.8A)
None
NAG  7 504 ( 3.9A)
0.95A17.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YKI_A_NFZA1219_1
(OXYGEN-INSENSITIVE
NAD(P)H
NITROREDUCTASE)		3j9f POLIOVIRUS RECEPTOR
(Homo
sapiens)		4 / 8TYR 7 121
ASN 7 120
GLU 7 118
GLY 7 119
None
NAG  7 404 ( 1.4A)
NAG  7 404 ( 4.4A)
NAG  7 404 (-3.6A)
0.85A17.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YKI_A_NFZA1219_1
(OXYGEN-INSENSITIVE
NAD(P)H
NITROREDUCTASE)		3rbs MYOMESIN-1
(Homo
sapiens)		4 / 8PHE A1418
ASN A1373
GLU A1371
GLY A1370
None
1.08A24.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YKI_A_NFZA1219_1
(OXYGEN-INSENSITIVE
NAD(P)H
NITROREDUCTASE)		4fao ACTIVIN RECEPTOR
TYPE-2B
(Homo
sapiens)		4 / 8TYR E  42
PHE E  95
ASN E  92
GLY E  58
None
1.01A18.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YKI_A_NFZA1219_1
(OXYGEN-INSENSITIVE
NAD(P)H
NITROREDUCTASE)		4hxx METHIONINE
AMINOPEPTIDASE 1
(Homo
sapiens)		4 / 8TYR A 196
PHE A 198
ASN A 197
GLY A 123
None
1AY  A 405 (-3.4A)
None
None
1.08A21.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YKI_A_NFZA1219_1
(OXYGEN-INSENSITIVE
NAD(P)H
NITROREDUCTASE)		4py4 POLY [ADP-RIBOSE]
POLYMERASE 14
(Homo
sapiens)		4 / 8TYR A1739
PHE A1681
THR A1713
PHE A1697
None
1.07A21.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YKI_A_NFZA1219_1
(OXYGEN-INSENSITIVE
NAD(P)H
NITROREDUCTASE)		5hdt SISTER CHROMATID
COHESION PROTEIN
PDS5 HOMOLOG B
(Homo
sapiens)		4 / 8TYR A 128
PHE A 129
GLY A 116
THR A 160
None
1.03A12.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YKI_A_NFZA1219_1
(OXYGEN-INSENSITIVE
NAD(P)H
NITROREDUCTASE)		5nx2 GLUCAGON-LIKE
PEPTIDE 1 RECEPTOR
(Homo
sapiens)		4 / 8PHE A 321
ASN A 320
GLU A 247
GLY A 248
None
0.70A18.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YKI_A_NFZA1219_1
(OXYGEN-INSENSITIVE
NAD(P)H
NITROREDUCTASE)		5uz7 CALCITONIN RECEPTOR
(Homo
sapiens)		4 / 8PHE R 313
ASN R 312
GLU R 240
GLY R 241
None
0.84A15.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YKI_A_NFZA1219_1
(OXYGEN-INSENSITIVE
NAD(P)H
NITROREDUCTASE)		5wy0 SMALL RNA
2'-O-METHYLTRANSFERA
SE
(Homo
sapiens)		4 / 8TYR A 192
PHE A 160
ASN A 134
GLY A 191
None
1.03A16.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YKI_A_NFZA1219_1
(OXYGEN-INSENSITIVE
NAD(P)H
NITROREDUCTASE)		6b3j GLUCAGON-LIKE
PEPTIDE 1 RECEPTOR
(Homo
sapiens)		4 / 8PHE R 321
ASN R 320
GLU R 247
GLY R 248
None
0.91A13.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YKI_A_NFZA1219_1
(OXYGEN-INSENSITIVE
NAD(P)H
NITROREDUCTASE)		6cd8 GLUCOSE-INDUCED
DEGRADATION PROTEIN
4 HOMOLOG
(Homo
sapiens)		4 / 8TYR A 272
GLU A 270
GLY A 271
PHE A 205
None
1.09A12.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YKI_B_NFZB2219_1
(OXYGEN-INSENSITIVE
NAD(P)H
NITROREDUCTASE)		1h4r MERLIN
(Homo
sapiens)		4 / 8THR A  28
PHE A  96
PHE A  61
GLY A  63
None
1.08A23.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YKI_B_NFZB2219_1
(OXYGEN-INSENSITIVE
NAD(P)H
NITROREDUCTASE)		2o6l UDP-GLUCURONOSYLTRAN
SFERASE 2B7
(Homo
sapiens)		4 / 8TYR A 438
ASN A 441
LYS A 444
GLY A 410
None
0.94A21.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YKI_B_NFZB2219_1
(OXYGEN-INSENSITIVE
NAD(P)H
NITROREDUCTASE)		2y23 MYOMESIN
(Homo
sapiens)		4 / 8PHE A1418
ASN A1373
GLU A1371
GLY A1370
None
1.04A23.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YKI_B_NFZB2219_1
(OXYGEN-INSENSITIVE
NAD(P)H
NITROREDUCTASE)		3j8f POLIOVIRUS RECEPTOR
(Homo
sapiens)		4 / 8TYR 7 121
ASN 7 120
GLU 7 118
GLY 7 119
None
NAG  7 504 ( 1.8A)
None
NAG  7 504 ( 3.9A)
0.95A17.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YKI_B_NFZB2219_1
(OXYGEN-INSENSITIVE
NAD(P)H
NITROREDUCTASE)		3j9f POLIOVIRUS RECEPTOR
(Homo
sapiens)		4 / 8TYR 7 121
ASN 7 120
GLU 7 118
GLY 7 119
None
NAG  7 404 ( 1.4A)
NAG  7 404 ( 4.4A)
NAG  7 404 (-3.6A)
0.84A17.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YKI_B_NFZB2219_1
(OXYGEN-INSENSITIVE
NAD(P)H
NITROREDUCTASE)		3rbs MYOMESIN-1
(Homo
sapiens)		4 / 8PHE A1418
ASN A1373
GLU A1371
GLY A1370
None
1.07A24.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YKI_B_NFZB2219_1
(OXYGEN-INSENSITIVE
NAD(P)H
NITROREDUCTASE)		4fao ACTIVIN RECEPTOR
TYPE-2B
(Homo
sapiens)		4 / 8TYR E  42
PHE E  95
ASN E  92
GLY E  58
None
1.02A18.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YKI_B_NFZB2219_1
(OXYGEN-INSENSITIVE
NAD(P)H
NITROREDUCTASE)		4py4 POLY [ADP-RIBOSE]
POLYMERASE 14
(Homo
sapiens)		4 / 8THR A1713
PHE A1697
TYR A1739
PHE A1681
None
1.06A21.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YKI_B_NFZB2219_1
(OXYGEN-INSENSITIVE
NAD(P)H
NITROREDUCTASE)		5nx2 GLUCAGON-LIKE
PEPTIDE 1 RECEPTOR
(Homo
sapiens)		4 / 8PHE A 321
ASN A 320
GLU A 247
GLY A 248
None
0.70A18.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YKI_B_NFZB2219_1
(OXYGEN-INSENSITIVE
NAD(P)H
NITROREDUCTASE)		5uz7 CALCITONIN RECEPTOR
(Homo
sapiens)		4 / 8PHE R 313
ASN R 312
GLU R 240
GLY R 241
None
0.83A15.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YKI_B_NFZB2219_1
(OXYGEN-INSENSITIVE
NAD(P)H
NITROREDUCTASE)		6b3j GLUCAGON-LIKE
PEPTIDE 1 RECEPTOR
(Homo
sapiens)		4 / 8PHE R 321
ASN R 320
GLU R 247
GLY R 248
None
0.88A13.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YKI_C_NFZC3219_1
(OXYGEN-INSENSITIVE
NAD(P)H
NITROREDUCTASE)		1e5w MOESIN
(Homo
sapiens)		4 / 8PHE A  44
GLY A  46
THR A  11
PHE A  80
None
1.08A22.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YKI_C_NFZC3219_1
(OXYGEN-INSENSITIVE
NAD(P)H
NITROREDUCTASE)		1h4r MERLIN
(Homo
sapiens)		4 / 8PHE A  61
GLY A  63
THR A  28
PHE A  96
None
1.07A23.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YKI_C_NFZC3219_1
(OXYGEN-INSENSITIVE
NAD(P)H
NITROREDUCTASE)		2o6l UDP-GLUCURONOSYLTRAN
SFERASE 2B7
(Homo
sapiens)		4 / 8TYR A 438
ASN A 441
LYS A 444
GLY A 410
None
0.90A21.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YKI_C_NFZC3219_1
(OXYGEN-INSENSITIVE
NAD(P)H
NITROREDUCTASE)		2y23 MYOMESIN
(Homo
sapiens)		4 / 8PHE A1418
ASN A1373
GLU A1371
GLY A1370
None
1.02A23.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YKI_C_NFZC3219_1
(OXYGEN-INSENSITIVE
NAD(P)H
NITROREDUCTASE)		3j8f POLIOVIRUS RECEPTOR
(Homo
sapiens)		4 / 8TYR 7 121
ASN 7 120
GLU 7 118
GLY 7 119
None
NAG  7 504 ( 1.8A)
None
NAG  7 504 ( 3.9A)
0.90A17.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YKI_C_NFZC3219_1
(OXYGEN-INSENSITIVE
NAD(P)H
NITROREDUCTASE)		3j9f POLIOVIRUS RECEPTOR
(Homo
sapiens)		4 / 8TYR 7 121
ASN 7 120
GLU 7 118
GLY 7 119
None
NAG  7 404 ( 1.4A)
NAG  7 404 ( 4.4A)
NAG  7 404 (-3.6A)
0.81A17.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YKI_C_NFZC3219_1
(OXYGEN-INSENSITIVE
NAD(P)H
NITROREDUCTASE)		3rbs MYOMESIN-1
(Homo
sapiens)		4 / 8PHE A1418
ASN A1373
GLU A1371
GLY A1370
None
1.05A24.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YKI_C_NFZC3219_1
(OXYGEN-INSENSITIVE
NAD(P)H
NITROREDUCTASE)		4fao ACTIVIN RECEPTOR
TYPE-2B
(Homo
sapiens)		4 / 8TYR E  42
PHE E  95
ASN E  92
GLY E  58
None
1.00A18.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YKI_C_NFZC3219_1
(OXYGEN-INSENSITIVE
NAD(P)H
NITROREDUCTASE)		4hxx METHIONINE
AMINOPEPTIDASE 1
(Homo
sapiens)		4 / 8TYR A 196
PHE A 198
ASN A 197
GLY A 123
None
1AY  A 405 (-3.4A)
None
None
1.07A21.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YKI_C_NFZC3219_1
(OXYGEN-INSENSITIVE
NAD(P)H
NITROREDUCTASE)		5nx2 GLUCAGON-LIKE
PEPTIDE 1 RECEPTOR
(Homo
sapiens)		4 / 8PHE A 321
ASN A 320
GLU A 247
GLY A 248
None
0.70A18.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YKI_C_NFZC3219_1
(OXYGEN-INSENSITIVE
NAD(P)H
NITROREDUCTASE)		5uz7 CALCITONIN RECEPTOR
(Homo
sapiens)		4 / 8PHE R 313
ASN R 312
GLU R 240
GLY R 241
None
0.84A15.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YKI_C_NFZC3219_1
(OXYGEN-INSENSITIVE
NAD(P)H
NITROREDUCTASE)		6b3j GLUCAGON-LIKE
PEPTIDE 1 RECEPTOR
(Homo
sapiens)		4 / 8PHE R 321
ASN R 320
GLU R 247
GLY R 248
None
0.90A13.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YKI_D_NFZD4219_1
(OXYGEN-INSENSITIVE
NAD(P)H
NITROREDUCTASE)		1h4r MERLIN
(Homo
sapiens)		4 / 8THR A  28
PHE A  96
PHE A  61
GLY A  63
None
1.08A23.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YKI_D_NFZD4219_1
(OXYGEN-INSENSITIVE
NAD(P)H
NITROREDUCTASE)		2o6l UDP-GLUCURONOSYLTRAN
SFERASE 2B7
(Homo
sapiens)		4 / 8TYR A 438
ASN A 441
LYS A 444
GLY A 410
None
0.91A21.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YKI_D_NFZD4219_1
(OXYGEN-INSENSITIVE
NAD(P)H
NITROREDUCTASE)		2y23 MYOMESIN
(Homo
sapiens)		4 / 8PHE A1418
ASN A1373
GLU A1371
GLY A1370
None
1.06A23.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YKI_D_NFZD4219_1
(OXYGEN-INSENSITIVE
NAD(P)H
NITROREDUCTASE)		3j8f POLIOVIRUS RECEPTOR
(Homo
sapiens)		4 / 8TYR 7 121
ASN 7 120
GLU 7 118
GLY 7 119
None
NAG  7 504 ( 1.8A)
None
NAG  7 504 ( 3.9A)
0.91A17.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YKI_D_NFZD4219_1
(OXYGEN-INSENSITIVE
NAD(P)H
NITROREDUCTASE)		3j9f POLIOVIRUS RECEPTOR
(Homo
sapiens)		4 / 8TYR 7 121
ASN 7 120
GLU 7 118
GLY 7 119
None
NAG  7 404 ( 1.4A)
NAG  7 404 ( 4.4A)
NAG  7 404 (-3.6A)
0.83A17.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YKI_D_NFZD4219_1
(OXYGEN-INSENSITIVE
NAD(P)H
NITROREDUCTASE)		4fao ACTIVIN RECEPTOR
TYPE-2B
(Homo
sapiens)		4 / 8TYR E  42
PHE E  95
ASN E  92
GLY E  58
None
1.01A18.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YKI_D_NFZD4219_1
(OXYGEN-INSENSITIVE
NAD(P)H
NITROREDUCTASE)		4hxx METHIONINE
AMINOPEPTIDASE 1
(Homo
sapiens)		4 / 8TYR A 196
PHE A 198
ASN A 197
GLY A 123
None
1AY  A 405 (-3.4A)
None
None
1.08A21.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YKI_D_NFZD4219_1
(OXYGEN-INSENSITIVE
NAD(P)H
NITROREDUCTASE)		4mwt LYSOSOMAL PROTECTIVE
PROTEIN
(Homo
sapiens)		4 / 8TYR A 367
PHE A 377
GLU A 149
GLY A 177
TYR  A 367 ( 1.3A)
PHE  A 377 ( 1.3A)
GLU  A 149 ( 0.5A)
GLY  A 177 ( 0.0A)
0.98A16.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YKI_D_NFZD4219_1
(OXYGEN-INSENSITIVE
NAD(P)H
NITROREDUCTASE)		4py4 POLY [ADP-RIBOSE]
POLYMERASE 14
(Homo
sapiens)		4 / 8THR A1713
PHE A1697
TYR A1739
PHE A1681
None
1.06A21.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YKI_D_NFZD4219_1
(OXYGEN-INSENSITIVE
NAD(P)H
NITROREDUCTASE)		5nx2 GLUCAGON-LIKE
PEPTIDE 1 RECEPTOR
(Homo
sapiens)		4 / 8PHE A 321
ASN A 320
GLU A 247
GLY A 248
None
0.70A18.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YKI_D_NFZD4219_1
(OXYGEN-INSENSITIVE
NAD(P)H
NITROREDUCTASE)		5uz7 CALCITONIN RECEPTOR
(Homo
sapiens)		4 / 8PHE R 313
ASN R 312
GLU R 240
GLY R 241
None
0.84A15.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YKI_D_NFZD4219_1
(OXYGEN-INSENSITIVE
NAD(P)H
NITROREDUCTASE)		5wy0 SMALL RNA
2'-O-METHYLTRANSFERA
SE
(Homo
sapiens)		4 / 8TYR A 192
PHE A 160
ASN A 134
GLY A 191
None
1.04A16.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YKI_D_NFZD4219_1
(OXYGEN-INSENSITIVE
NAD(P)H
NITROREDUCTASE)		6b3j GLUCAGON-LIKE
PEPTIDE 1 RECEPTOR
(Homo
sapiens)		4 / 8PHE R 321
ASN R 320
GLU R 247
GLY R 248
None
0.90A13.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3R6W_A_NFZA213_1
(FMN-DEPENDENT
NADH-AZOREDUCTASE 1)		1nty TRIPLE FUNCTIONAL
DOMAIN PROTEIN
(Homo
sapiens)		5 / 10PHE A1291
GLU A1245
VAL A1310
TYR A1373
PHE A1314
None
1.24A19.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3R6W_A_NFZA213_1
(FMN-DEPENDENT
NADH-AZOREDUCTASE 1)		3e73 LANC-LIKE PROTEIN 1
(Homo
sapiens)		5 / 10PHE A 373
VAL A 116
PHE A 164
TYR A 160
PHE A 106
None
1.36A19.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3R6W_A_NFZA213_1
(FMN-DEPENDENT
NADH-AZOREDUCTASE 1)		3g4e REGUCALCIN
(Homo
sapiens)		5 / 10PHE A 114
GLY A 116
PHE A 178
TYR A 167
PHE A 165
None
1.35A22.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3R6W_A_NFZA213_1
(FMN-DEPENDENT
NADH-AZOREDUCTASE 1)		3no8 BTB/POZ
DOMAIN-CONTAINING
PROTEIN 2
(Homo
sapiens)		5 / 10GLY A 405
PHE A 453
VAL A 397
PHE A 499
PHE A 395
None
1.49A19.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3R6W_A_NFZA213_1
(FMN-DEPENDENT
NADH-AZOREDUCTASE 1)		4byf UNCONVENTIONAL
MYOSIN-IC
(Homo
sapiens)		5 / 10ASN A 404
GLY A 105
GLU A 106
VAL A 516
TYR A 613
None
1.46A15.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3R6W_A_NFZA213_1
(FMN-DEPENDENT
NADH-AZOREDUCTASE 1)		4h6j ARYL HYDROCARBON
NUCLEAR TRANSLOCATOR
(Homo
sapiens)		5 / 10ASN B 461
GLY B 371
PHE B 412
PHE B 429
PHE B 427
None
1.50A21.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3R6W_A_NFZA213_1
(FMN-DEPENDENT
NADH-AZOREDUCTASE 1)		4jra SYNAPTIC VESICLE
GLYCOPROTEIN 2C
(Homo
sapiens)		5 / 10PHE C 547
PHE C 552
VAL C 505
PHE C 502
PHE C 522
None
1.49A19.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3R6W_A_NFZA213_1
(FMN-DEPENDENT
NADH-AZOREDUCTASE 1)		4tnb G PROTEIN-COUPLED
RECEPTOR KINASE 5
(Homo
sapiens)		5 / 10GLY A 209
GLU A 514
VAL A 181
TYR A 212
PHE A 186
None
1.37A15.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3R6W_A_NFZA213_1
(FMN-DEPENDENT
NADH-AZOREDUCTASE 1)		5una 7SK SNRNA
METHYLPHOSPHATE
CAPPING ENZYME
(Homo
sapiens)		5 / 10ASN A 552
GLY A 455
PHE A 555
TYR A 490
PHE A 549
None
1.28A21.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3R6W_A_NFZA213_1
(FMN-DEPENDENT
NADH-AZOREDUCTASE 1)		5w0m TERMINAL
URIDYLYLTRANSFERASE
7
(Homo
sapiens)		5 / 10GLY A1317
PHE A 997
VAL A1004
PHE A1329
TYR A1328
None
1.47A20.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3R6W_A_NFZA214_1
(FMN-DEPENDENT
NADH-AZOREDUCTASE 1)		1w6j LANOSTEROL SYNTHASE
(Homo
sapiens)		5 / 10PHE A 391
TYR A 707
PHE A 711
GLY A 582
ASN A 651
None
1.20A14.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3R6W_A_NFZA214_1
(FMN-DEPENDENT
NADH-AZOREDUCTASE 1)		3e73 LANC-LIKE PROTEIN 1
(Homo
sapiens)		5 / 10VAL A 116
PHE A 164
TYR A 160
PHE A 106
PHE A 373
None
1.32A19.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3R6W_A_NFZA214_1
(FMN-DEPENDENT
NADH-AZOREDUCTASE 1)		3no8 BTB/POZ
DOMAIN-CONTAINING
PROTEIN 2
(Homo
sapiens)		5 / 10VAL A 397
PHE A 499
PHE A 395
GLY A 405
PHE A 453
None
1.46A19.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3R6W_A_NFZA214_1
(FMN-DEPENDENT
NADH-AZOREDUCTASE 1)		5hdt SISTER CHROMATID
COHESION PROTEIN
PDS5 HOMOLOG B
(Homo
sapiens)		5 / 10ASN A 151
PHE A 154
GLY A 188
PHE A 145
ASN A 142
None
1.36A10.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3R6W_A_NFZA214_1
(FMN-DEPENDENT
NADH-AZOREDUCTASE 1)		5una 7SK SNRNA
METHYLPHOSPHATE
CAPPING ENZYME
(Homo
sapiens)		5 / 10TYR A 490
PHE A 549
ASN A 552
GLY A 455
PHE A 555
None
1.22A21.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3R6W_A_NFZA214_1
(FMN-DEPENDENT
NADH-AZOREDUCTASE 1)		5wy0 SMALL RNA
2'-O-METHYLTRANSFERA
SE
(Homo
sapiens)		5 / 10PHE A 177
VAL A 167
PHE A 199
PHE A 120
PHE A 115
None
1.47A15.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3R6W_A_NFZA214_1
(FMN-DEPENDENT
NADH-AZOREDUCTASE 1)		6dd3 CYTOSOLIC PURINE
5'-NUCLEOTIDASE
(Homo
sapiens)		5 / 10PHE A  89
VAL A 201
PHE A 102
GLY A 124
ASN A 108
None
1.38A20.00