POTENTIAL TARGETS FROM HUMAN (RESULTS FROM SUB-STRUCTURAL SIMILARITY SEARCHES)
1) User may click on the DrReposER ID (the second column) to get information on the binding sites and drug molecule.
2) Click View (the second last column) to view matched residues and superposition in the NGL viewer (upper right part).
3) User may also click on the Dock (the last column) to get script for molecular docking in UCSF Chimera through AutoDock Vina.

DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1SQN_A_NDRA1001_0
(PROGESTERONE
RECEPTOR)		1uhl RETINOIC ACID
RECEPTOR RXR-BETA
(Homo
sapiens)		5 / 12LEU A 496
LEU A 493
LEU A 490
LEU A 379
MET A 433
None
1.39A25.57
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1SQN_A_NDRA1001_0
(PROGESTERONE
RECEPTOR)		2ax9 ANDROGEN RECEPTOR
(Homo
sapiens)		7 / 12LEU A 701
LEU A 704
ASN A 705
LEU A 707
GLN A 711
MET A 742
MET A 745
None
BHM  A   1 (-4.0A)
BHM  A   1 (-3.6A)
BHM  A   1 ( 4.2A)
BHM  A   1 (-2.2A)
BHM  A   1 ( 4.0A)
BHM  A   1 (-3.9A)
0.59A53.26
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1SQN_A_NDRA1001_0
(PROGESTERONE
RECEPTOR)		2ax9 ANDROGEN RECEPTOR
(Homo
sapiens)		5 / 12LEU A 701
LEU A 704
ASN A 705
LEU A 707
LEU A 873
None
BHM  A   1 (-4.0A)
BHM  A   1 (-3.6A)
BHM  A   1 ( 4.2A)
BHM  A   1 (-4.4A)
1.44A53.26
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1SQN_A_NDRA1001_0
(PROGESTERONE
RECEPTOR)		2ax9 ANDROGEN RECEPTOR
(Homo
sapiens)		7 / 12LEU A 701
LEU A 704
LEU A 707
GLN A 711
MET A 742
MET A 745
MET A 787
None
BHM  A   1 (-4.0A)
BHM  A   1 ( 4.2A)
BHM  A   1 (-2.2A)
BHM  A   1 ( 4.0A)
BHM  A   1 (-3.9A)
BHM  A   1 (-3.6A)
0.75A53.26
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1SQN_A_NDRA1001_0
(PROGESTERONE
RECEPTOR)		2ax9 ANDROGEN RECEPTOR
(Homo
sapiens)		5 / 12LEU A 707
GLN A 711
MET A 742
MET A 745
MET A 895
BHM  A   1 ( 4.2A)
BHM  A   1 (-2.2A)
BHM  A   1 ( 4.0A)
BHM  A   1 (-3.9A)
None
1.08A53.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1SQN_A_NDRA1001_0
(PROGESTERONE
RECEPTOR)		2gpv ESTROGEN-RELATED
RECEPTOR GAMMA
(Homo
sapiens)		5 / 12LEU A 265
LEU A 268
LEU A 271
MET A 306
LEU A 345
None
OHT  A 500 (-4.1A)
OHT  A 500 ( 4.4A)
OHT  A 500 (-3.9A)
OHT  A 500 (-4.3A)
0.40A28.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1SQN_A_NDRA1001_0
(PROGESTERONE
RECEPTOR)		2z63 TOLL-LIKE RECEPTOR
4, VARIABLE
LYMPHOCYTE RECEPTOR
B
(Eptatretus
burgeri;
Homo
sapiens)		5 / 12LEU A 401
LEU A 421
LEU A 419
MET A 414
LEU A 427
None
1.49A18.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1SQN_A_NDRA1001_0
(PROGESTERONE
RECEPTOR)		2z66 VARIABLE LYMPHOCYTE
RECEPTOR B,
TOLL-LIKE RECEPTOR 4
(Eptatretus
burgeri;
Homo
sapiens)		5 / 12LEU A 401
LEU A 421
LEU A 419
MET A 414
LEU A 427
None
1.48A26.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1SQN_A_NDRA1001_0
(PROGESTERONE
RECEPTOR)		3eap RHO
GTPASE-ACTIVATING
PROTEIN 11A
(Homo
sapiens)		5 / 12LEU A  15
LEU A  12
LEU A   9
LEU A 137
CYH A 161
None
1.18A21.88
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1SQN_A_NDRA1001_0
(PROGESTERONE
RECEPTOR)		3kba PROGESTERONE
RECEPTOR
(Homo
sapiens)		9 / 12LEU A 715
LEU A 718
ASN A 719
LEU A 721
GLN A 725
MET A 756
MET A 759
MET A 801
CYH A 891
WOW  A   1 (-3.9A)
WOW  A   1 (-4.2A)
WOW  A   1 (-3.3A)
WOW  A   1 ( 4.3A)
WOW  A   1 ( 4.1A)
WOW  A   1 ( 4.1A)
WOW  A   1 (-3.7A)
WOW  A   1 (-4.2A)
WOW  A   1 (-3.5A)
0.56A100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1SQN_A_NDRA1001_0
(PROGESTERONE
RECEPTOR)		3kba PROGESTERONE
RECEPTOR
(Homo
sapiens)		10 / 12LEU A 715
LEU A 718
ASN A 719
LEU A 721
MET A 756
MET A 759
MET A 801
TYR A 890
CYH A 891
MET A 909
WOW  A   1 (-3.9A)
WOW  A   1 (-4.2A)
WOW  A   1 (-3.3A)
WOW  A   1 ( 4.3A)
WOW  A   1 ( 4.1A)
WOW  A   1 (-3.7A)
WOW  A   1 (-4.2A)
WOW  A   1 (-3.9A)
WOW  A   1 (-3.5A)
None
0.59A100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1SQN_A_NDRA1001_0
(PROGESTERONE
RECEPTOR)		3kba PROGESTERONE
RECEPTOR
(Homo
sapiens)		5 / 12LEU A 715
MET A 756
LEU A 797
TYR A 890
CYH A 891
WOW  A   1 (-3.9A)
WOW  A   1 ( 4.1A)
WOW  A   1 ( 4.5A)
WOW  A   1 (-3.9A)
WOW  A   1 (-3.5A)
0.98A100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1SQN_A_NDRA1001_0
(PROGESTERONE
RECEPTOR)		3kba PROGESTERONE
RECEPTOR
(Homo
sapiens)		5 / 12LEU A 721
LEU A 718
LEU A 715
LEU A 763
MET A 801
WOW  A   1 ( 4.3A)
WOW  A   1 (-4.2A)
WOW  A   1 (-3.9A)
WOW  A   1 ( 4.0A)
WOW  A   1 (-4.2A)
1.19A100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1SQN_A_NDRA1001_0
(PROGESTERONE
RECEPTOR)		3kn5 RIBOSOMAL PROTEIN S6
KINASE ALPHA-5
(Homo
sapiens)		5 / 12LEU A 676
LEU A 667
LEU A 668
LEU A 687
MET A 525
None
1.30A21.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1SQN_A_NDRA1001_0
(PROGESTERONE
RECEPTOR)		4b99 MITOGEN-ACTIVATED
PROTEIN KINASE 7
(Homo
sapiens)		5 / 12LEU A 166
ASN A 113
LEU A 167
LEU A 144
MET A 255
None
1.25A19.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1SQN_A_NDRA1001_0
(PROGESTERONE
RECEPTOR)		4bsn EXPORTIN-1
(Homo
sapiens)		5 / 12LEU A 351
LEU A 347
LEU A 343
TYR A 372
MET A 291
None
1.27A14.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1SQN_A_NDRA1001_0
(PROGESTERONE
RECEPTOR)		4ez5 CYCLIN-DEPENDENT
KINASE 6
(Homo
sapiens)		5 / 12LEU A 129
ASN A  75
LEU A 130
LEU A 105
MET A 212
None
1.29A21.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1SQN_A_NDRA1001_0
(PROGESTERONE
RECEPTOR)		4ol0 TRANSPORTIN-3
(Homo
sapiens)		5 / 12LEU B   8
LEU B  50
LEU B  51
MET B  67
LEU B  37
None
1.36A14.96
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1SQN_A_NDRA1001_0
(PROGESTERONE
RECEPTOR)		4p6w GLUCOCORTICOID
RECEPTOR
(Homo
sapiens)		6 / 12ASN A 564
GLN A 570
MET A 601
MET A 646
TYR A 735
CYH A 736
MOF  A 801 (-3.0A)
MOF  A 801 (-2.9A)
MOF  A 801 (-3.7A)
MOF  A 801 (-4.4A)
MOF  A 801 (-4.8A)
MOF  A 801 (-3.7A)
0.67A54.47
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1SQN_A_NDRA1001_0
(PROGESTERONE
RECEPTOR)		4p6w GLUCOCORTICOID
RECEPTOR
(Homo
sapiens)		7 / 12LEU A 563
ASN A 564
LEU A 566
GLN A 570
MET A 601
MET A 604
MET A 646
MOF  A 801 (-3.9A)
MOF  A 801 (-3.0A)
MOF  A 801 ( 4.6A)
MOF  A 801 (-2.9A)
MOF  A 801 (-3.7A)
None
MOF  A 801 (-4.4A)
0.90A54.47
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1SQN_A_NDRA1001_0
(PROGESTERONE
RECEPTOR)		4p6w GLUCOCORTICOID
RECEPTOR
(Homo
sapiens)		7 / 12LEU A 563
ASN A 564
LEU A 566
GLN A 570
MET A 601
MET A 646
CYH A 736
MOF  A 801 (-3.9A)
MOF  A 801 (-3.0A)
MOF  A 801 ( 4.6A)
MOF  A 801 (-2.9A)
MOF  A 801 (-3.7A)
MOF  A 801 (-4.4A)
MOF  A 801 (-3.7A)
0.66A54.47
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1SQN_A_NDRA1001_0
(PROGESTERONE
RECEPTOR)		4p6w GLUCOCORTICOID
RECEPTOR
(Homo
sapiens)		5 / 12LEU A 566
LEU A 563
MET A 639
LEU A 608
MET A 646
MOF  A 801 ( 4.6A)
MOF  A 801 (-3.9A)
MOF  A 801 (-3.7A)
MOF  A 801 ( 4.6A)
MOF  A 801 (-4.4A)
1.31A54.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1SQN_A_NDRA1001_0
(PROGESTERONE
RECEPTOR)		4roe TRANSCRIPTION FACTOR
IIIB 50 KDA SUBUNIT
(Homo
sapiens)		5 / 12LEU A 159
LEU A 160
LEU A 162
GLN A 128
LEU A 117
None
1.43A19.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1SQN_A_NDRA1001_0
(PROGESTERONE
RECEPTOR)		4u1a ENOYL-COA DELTA
ISOMERASE 2
(Homo
sapiens)		5 / 12LEU A 188
LEU A 189
ASN A 185
LEU A 336
GLN A 242
 CL  A 401 ( 4.9A)
CL  A 401 ( 4.4A)
CL  A 401 ( 4.2A)
None
None
1.29A19.46
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1SQN_A_NDRA1001_0
(PROGESTERONE
RECEPTOR)		4udb MINERALOCORTICOID
RECEPTOR
(Homo
sapiens)		5 / 12LEU A 766
ASN A 770
MET A 807
LEU A 848
CYH A 942
CV7  A1987 (-3.6A)
CV7  A1987 (-3.1A)
CV7  A1987 ( 3.9A)
CV7  A1987 ( 4.4A)
CV7  A1987 (-4.0A)
0.76A52.21
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1SQN_A_NDRA1001_0
(PROGESTERONE
RECEPTOR)		4udb MINERALOCORTICOID
RECEPTOR
(Homo
sapiens)		8 / 12LEU A 766
LEU A 769
ASN A 770
LEU A 772
GLN A 776
MET A 807
MET A 852
CYH A 942
CV7  A1987 (-3.6A)
CV7  A1987 (-4.1A)
CV7  A1987 (-3.1A)
CV7  A1987 ( 4.5A)
CV7  A1987 (-3.0A)
CV7  A1987 ( 3.9A)
CV7  A1987 ( 3.7A)
CV7  A1987 (-4.0A)
0.49A52.21
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1SQN_A_NDRA1001_0
(PROGESTERONE
RECEPTOR)		4udb MINERALOCORTICOID
RECEPTOR
(Homo
sapiens)		5 / 12LEU A 772
LEU A 769
LEU A 766
LEU A 814
MET A 852
CV7  A1987 ( 4.5A)
CV7  A1987 (-4.1A)
CV7  A1987 (-3.6A)
CV7  A1987 ( 4.0A)
CV7  A1987 ( 3.7A)
1.29A52.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1SQN_A_NDRA1001_0
(PROGESTERONE
RECEPTOR)		4y6o NAD-DEPENDENT
PROTEIN DEACETYLASE
SIRTUIN-2
(Homo
sapiens)		5 / 12LEU A 335
LEU A 329
GLN A 326
LEU A 258
MET A 260
None
1.25A24.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1SQN_A_NDRA1001_0
(PROGESTERONE
RECEPTOR)		5cqr ELONGATOR COMPLEX
PROTEIN 1
(Homo
sapiens)		5 / 12LEU A 918
LEU A 921
ASN A 922
LEU A 924
GLN A 932
None
0.94A18.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1SQN_A_NDRA1001_0
(PROGESTERONE
RECEPTOR)		5dot CARBAMOYL-PHOSPHATE
SYNTHASE [AMMONIA],
MITOCHONDRIAL
(Homo
sapiens)		5 / 12LEU A 526
LEU A 520
GLN A 490
LEU A 426
MET A 462
None
1.46A10.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1SQN_A_NDRA1001_0
(PROGESTERONE
RECEPTOR)		5hdh TOLL-LIKE RECEPTOR 8
(Homo
sapiens)		5 / 12LEU A 253
LEU A 294
LEU A 318
LEU A 289
MET A 310
None
1.45A16.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1SQN_A_NDRA1001_0
(PROGESTERONE
RECEPTOR)		5hdh TOLL-LIKE RECEPTOR 8
(Homo
sapiens)		5 / 12LEU A 542
LEU A 561
ASN A 564
LEU A 591
LEU A 535
None
1.41A16.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1SQN_A_NDRA1001_0
(PROGESTERONE
RECEPTOR)		5mwp MINERALOCORTICOID
RECEPTOR
(Homo
sapiens)		5 / 12LEU A 766
ASN A 770
MET A 807
LEU A 848
CYH A 942
ECV  A1101 ( 3.9A)
ECV  A1101 (-3.1A)
ECV  A1101 (-3.6A)
None
ECV  A1101 (-4.0A)
0.93Aundetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1SQN_A_NDRA1001_0
(PROGESTERONE
RECEPTOR)		5mwp MINERALOCORTICOID
RECEPTOR
(Homo
sapiens)		7 / 12LEU A 766
LEU A 769
ASN A 770
LEU A 772
GLN A 776
MET A 807
CYH A 942
ECV  A1101 ( 3.9A)
ECV  A1101 (-4.7A)
ECV  A1101 (-3.1A)
ECV  A1101 ( 3.9A)
ECV  A1101 (-2.9A)
ECV  A1101 (-3.6A)
ECV  A1101 (-4.0A)
0.48Aundetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1SQN_A_NDRA1001_0
(PROGESTERONE
RECEPTOR)		5yq5 OSTEOMODULIN
(Homo
sapiens)		5 / 12LEU A 169
LEU A 193
LEU A 219
LEU A 188
MET A 211
None
1.48Aundetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1SQN_A_NDRA1001_0
(PROGESTERONE
RECEPTOR)		6el8 FORKHEAD BOX PROTEIN
N1
(Homo
sapiens)		5 / 12LEU A 322
ASN A 321
LEU A 278
MET A 354
CYH A 327
None
1.27A18.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1SQN_B_NDRB2001_0
(PROGESTERONE
RECEPTOR)		1jl0 S-ADENOSYLMETHIONINE
DECARBOXYLASE
PROENZYME
(Homo
sapiens)		5 / 12LEU A  97
LEU A  94
LEU A  91
MET A  70
LEU A  44
None
1.16A21.76
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1SQN_B_NDRB2001_0
(PROGESTERONE
RECEPTOR)		2ax9 ANDROGEN RECEPTOR
(Homo
sapiens)		8 / 12LEU A 701
LEU A 704
ASN A 705
LEU A 707
GLN A 711
MET A 742
MET A 745
LEU A 873
None
BHM  A   1 (-4.0A)
BHM  A   1 (-3.6A)
BHM  A   1 ( 4.2A)
BHM  A   1 (-2.2A)
BHM  A   1 ( 4.0A)
BHM  A   1 (-3.9A)
BHM  A   1 (-4.4A)
0.73A53.26
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1SQN_B_NDRB2001_0
(PROGESTERONE
RECEPTOR)		2ax9 ANDROGEN RECEPTOR
(Homo
sapiens)		6 / 12LEU A 707
GLN A 711
MET A 742
MET A 745
MET A 787
LEU A 873
BHM  A   1 ( 4.2A)
BHM  A   1 (-2.2A)
BHM  A   1 ( 4.0A)
BHM  A   1 (-3.9A)
BHM  A   1 (-3.6A)
BHM  A   1 (-4.4A)
1.10A53.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1SQN_B_NDRB2001_0
(PROGESTERONE
RECEPTOR)		2gpv ESTROGEN-RELATED
RECEPTOR GAMMA
(Homo
sapiens)		5 / 12LEU A 265
LEU A 268
LEU A 271
MET A 306
LEU A 345
None
OHT  A 500 (-4.1A)
OHT  A 500 ( 4.4A)
OHT  A 500 (-3.9A)
OHT  A 500 (-4.3A)
0.51A28.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1SQN_B_NDRB2001_0
(PROGESTERONE
RECEPTOR)		2id5 LEUCINE RICH REPEAT
NEURONAL 6A
(Homo
sapiens)		5 / 12LEU A 253
LEU A 229
LEU A 205
MET A 216
LEU A 236
None
1.09A21.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1SQN_B_NDRB2001_0
(PROGESTERONE
RECEPTOR)		3eap RHO
GTPASE-ACTIVATING
PROTEIN 11A
(Homo
sapiens)		5 / 12LEU A  15
LEU A  12
LEU A   9
LEU A 137
CYH A 161
None
1.11A21.88
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1SQN_B_NDRB2001_0
(PROGESTERONE
RECEPTOR)		3kba PROGESTERONE
RECEPTOR
(Homo
sapiens)		9 / 12LEU A 715
ASN A 719
LEU A 721
GLN A 725
MET A 756
MET A 759
MET A 801
LEU A 887
CYH A 891
WOW  A   1 (-3.9A)
WOW  A   1 (-3.3A)
WOW  A   1 ( 4.3A)
WOW  A   1 ( 4.1A)
WOW  A   1 ( 4.1A)
WOW  A   1 (-3.7A)
WOW  A   1 (-4.2A)
WOW  A   1 (-4.0A)
WOW  A   1 (-3.5A)
0.60A100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1SQN_B_NDRB2001_0
(PROGESTERONE
RECEPTOR)		3kba PROGESTERONE
RECEPTOR
(Homo
sapiens)		10 / 12LEU A 715
LEU A 718
ASN A 719
LEU A 721
MET A 756
MET A 759
MET A 801
LEU A 887
TYR A 890
CYH A 891
WOW  A   1 (-3.9A)
WOW  A   1 (-4.2A)
WOW  A   1 (-3.3A)
WOW  A   1 ( 4.3A)
WOW  A   1 ( 4.1A)
WOW  A   1 (-3.7A)
WOW  A   1 (-4.2A)
WOW  A   1 (-4.0A)
WOW  A   1 (-3.9A)
WOW  A   1 (-3.5A)
0.37A100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1SQN_B_NDRB2001_0
(PROGESTERONE
RECEPTOR)		3kba PROGESTERONE
RECEPTOR
(Homo
sapiens)		6 / 12LEU A 721
LEU A 718
LEU A 715
LEU A 763
MET A 801
LEU A 776
WOW  A   1 ( 4.3A)
WOW  A   1 (-4.2A)
WOW  A   1 (-3.9A)
WOW  A   1 ( 4.0A)
WOW  A   1 (-4.2A)
None
1.11A100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1SQN_B_NDRB2001_0
(PROGESTERONE
RECEPTOR)		3kba PROGESTERONE
RECEPTOR
(Homo
sapiens)		6 / 12MET A 756
MET A 759
LEU A 797
LEU A 887
TYR A 890
CYH A 891
WOW  A   1 ( 4.1A)
WOW  A   1 (-3.7A)
WOW  A   1 ( 4.5A)
WOW  A   1 (-4.0A)
WOW  A   1 (-3.9A)
WOW  A   1 (-3.5A)
0.73A100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1SQN_B_NDRB2001_0
(PROGESTERONE
RECEPTOR)		4b3g DNA-BINDING PROTEIN
SMUBP-2
(Homo
sapiens)		5 / 12LEU A 166
LEU A 209
LEU A 390
LEU A 155
TYR A 158
None
1.12A17.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1SQN_B_NDRB2001_0
(PROGESTERONE
RECEPTOR)		4glp MONOCYTE
DIFFERENTIATION
ANTIGEN CD14
(Homo
sapiens)		5 / 12LEU A 227
LEU A 199
LEU A 175
LEU A 212
LEU A 207
None
1.04A20.56
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1SQN_B_NDRB2001_0
(PROGESTERONE
RECEPTOR)		4p6w GLUCOCORTICOID
RECEPTOR
(Homo
sapiens)		7 / 12ASN A 564
GLN A 570
MET A 601
MET A 646
LEU A 732
TYR A 735
CYH A 736
MOF  A 801 (-3.0A)
MOF  A 801 (-2.9A)
MOF  A 801 (-3.7A)
MOF  A 801 (-4.4A)
MOF  A 801 ( 4.2A)
MOF  A 801 (-4.8A)
MOF  A 801 (-3.7A)
0.51A54.47
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1SQN_B_NDRB2001_0
(PROGESTERONE
RECEPTOR)		4p6w GLUCOCORTICOID
RECEPTOR
(Homo
sapiens)		8 / 12LEU A 563
ASN A 564
LEU A 566
GLN A 570
MET A 601
MET A 646
LEU A 732
CYH A 736
MOF  A 801 (-3.9A)
MOF  A 801 (-3.0A)
MOF  A 801 ( 4.6A)
MOF  A 801 (-2.9A)
MOF  A 801 (-3.7A)
MOF  A 801 (-4.4A)
MOF  A 801 ( 4.2A)
MOF  A 801 (-3.7A)
0.57A54.47
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1SQN_B_NDRB2001_0
(PROGESTERONE
RECEPTOR)		4p6w GLUCOCORTICOID
RECEPTOR
(Homo
sapiens)		7 / 12LEU A 563
LEU A 566
GLN A 570
MET A 601
MET A 604
MET A 646
LEU A 732
MOF  A 801 (-3.9A)
MOF  A 801 ( 4.6A)
MOF  A 801 (-2.9A)
MOF  A 801 (-3.7A)
None
MOF  A 801 (-4.4A)
MOF  A 801 ( 4.2A)
0.85A54.47
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1SQN_B_NDRB2001_0
(PROGESTERONE
RECEPTOR)		4p6w GLUCOCORTICOID
RECEPTOR
(Homo
sapiens)		6 / 12LEU A 566
LEU A 563
MET A 639
LEU A 608
MET A 646
LEU A 621
MOF  A 801 ( 4.6A)
MOF  A 801 (-3.9A)
MOF  A 801 (-3.7A)
MOF  A 801 ( 4.6A)
MOF  A 801 (-4.4A)
None
1.28A54.47
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1SQN_B_NDRB2001_0
(PROGESTERONE
RECEPTOR)		4udb MINERALOCORTICOID
RECEPTOR
(Homo
sapiens)		7 / 12LEU A 766
ASN A 770
GLN A 776
MET A 807
LEU A 848
LEU A 938
CYH A 942
CV7  A1987 (-3.6A)
CV7  A1987 (-3.1A)
CV7  A1987 (-3.0A)
CV7  A1987 ( 3.9A)
CV7  A1987 ( 4.4A)
CV7  A1987 ( 3.9A)
CV7  A1987 (-4.0A)
0.71A52.21
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1SQN_B_NDRB2001_0
(PROGESTERONE
RECEPTOR)		4udb MINERALOCORTICOID
RECEPTOR
(Homo
sapiens)		9 / 12LEU A 766
LEU A 769
ASN A 770
LEU A 772
GLN A 776
MET A 807
MET A 852
LEU A 938
CYH A 942
CV7  A1987 (-3.6A)
CV7  A1987 (-4.1A)
CV7  A1987 (-3.1A)
CV7  A1987 ( 4.5A)
CV7  A1987 (-3.0A)
CV7  A1987 ( 3.9A)
CV7  A1987 ( 3.7A)
CV7  A1987 ( 3.9A)
CV7  A1987 (-4.0A)
0.55A52.21
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1SQN_B_NDRB2001_0
(PROGESTERONE
RECEPTOR)		4udb MINERALOCORTICOID
RECEPTOR
(Homo
sapiens)		6 / 12LEU A 772
LEU A 769
LEU A 766
LEU A 814
MET A 852
LEU A 827
CV7  A1987 ( 4.5A)
CV7  A1987 (-4.1A)
CV7  A1987 (-3.6A)
CV7  A1987 ( 4.0A)
CV7  A1987 ( 3.7A)
None
1.27A52.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1SQN_B_NDRB2001_0
(PROGESTERONE
RECEPTOR)		5mwp MINERALOCORTICOID
RECEPTOR
(Homo
sapiens)		7 / 12LEU A 766
ASN A 770
GLN A 776
MET A 807
LEU A 848
LEU A 938
CYH A 942
ECV  A1101 ( 3.9A)
ECV  A1101 (-3.1A)
ECV  A1101 (-2.9A)
ECV  A1101 (-3.6A)
None
ECV  A1101 ( 4.3A)
ECV  A1101 (-4.0A)
0.85Aundetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1SQN_B_NDRB2001_0
(PROGESTERONE
RECEPTOR)		5mwp MINERALOCORTICOID
RECEPTOR
(Homo
sapiens)		8 / 12LEU A 766
LEU A 769
ASN A 770
LEU A 772
GLN A 776
MET A 807
LEU A 938
CYH A 942
ECV  A1101 ( 3.9A)
ECV  A1101 (-4.7A)
ECV  A1101 (-3.1A)
ECV  A1101 ( 3.9A)
ECV  A1101 (-2.9A)
ECV  A1101 (-3.6A)
ECV  A1101 ( 4.3A)
ECV  A1101 (-4.0A)
0.41Aundetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1SQN_B_NDRB2001_0
(PROGESTERONE
RECEPTOR)		5mwp MINERALOCORTICOID
RECEPTOR
(Homo
sapiens)		5 / 12LEU A 772
LEU A 769
LEU A 766
LEU A 814
LEU A 827
ECV  A1101 ( 3.9A)
ECV  A1101 (-4.7A)
ECV  A1101 ( 3.9A)
ECV  A1101 (-4.1A)
None
1.13Aundetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1SQN_B_NDRB2001_0
(PROGESTERONE
RECEPTOR)		5oj8 KINESIN LIGHT CHAIN
1
(Homo
sapiens)		5 / 12LEU A 213
LEU A 216
LEU A 219
LEU A 240
LEU A 261
None
0.90A19.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2W8Y_B_NDRB1000_0
(PROGESTERONE
RECEPTOR)		1xb7 STEROID HORMONE
RECEPTOR ERR1
(Homo
sapiens)		5 / 12LEU A 324
LEU A 327
MET A 362
ARG A 372
LEU A 401
None
0.62A27.17
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2W8Y_B_NDRB1000_0
(PROGESTERONE
RECEPTOR)		2ax9 ANDROGEN RECEPTOR
(Homo
sapiens)		8 / 12LEU A 701
LEU A 704
ASN A 705
LEU A 707
GLN A 711
MET A 742
MET A 745
ARG A 752
None
BHM  A   1 (-4.0A)
BHM  A   1 (-3.6A)
BHM  A   1 ( 4.2A)
BHM  A   1 (-2.2A)
BHM  A   1 ( 4.0A)
BHM  A   1 (-3.9A)
BHM  A   1 (-3.8A)
0.55A53.85
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2W8Y_B_NDRB1000_0
(PROGESTERONE
RECEPTOR)		2ax9 ANDROGEN RECEPTOR
(Homo
sapiens)		5 / 12LEU A 701
LEU A 704
ASN A 705
LEU A 707
LEU A 873
None
BHM  A   1 (-4.0A)
BHM  A   1 (-3.6A)
BHM  A   1 ( 4.2A)
BHM  A   1 (-4.4A)
1.49A53.85
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2W8Y_B_NDRB1000_0
(PROGESTERONE
RECEPTOR)		2ax9 ANDROGEN RECEPTOR
(Homo
sapiens)		8 / 12LEU A 701
LEU A 704
LEU A 707
GLN A 711
MET A 742
MET A 745
ARG A 752
MET A 787
None
BHM  A   1 (-4.0A)
BHM  A   1 ( 4.2A)
BHM  A   1 (-2.2A)
BHM  A   1 ( 4.0A)
BHM  A   1 (-3.9A)
BHM  A   1 (-3.8A)
BHM  A   1 (-3.6A)
0.80A53.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2W8Y_B_NDRB1000_0
(PROGESTERONE
RECEPTOR)		2gpv ESTROGEN-RELATED
RECEPTOR GAMMA
(Homo
sapiens)		6 / 12LEU A 265
LEU A 268
LEU A 271
MET A 306
ARG A 316
LEU A 345
None
OHT  A 500 (-4.1A)
OHT  A 500 ( 4.4A)
OHT  A 500 (-3.9A)
OHT  A 500 (-3.8A)
OHT  A 500 (-4.3A)
0.48A28.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2W8Y_B_NDRB1000_0
(PROGESTERONE
RECEPTOR)		2h2m COMM
DOMAIN-CONTAINING
PROTEIN 1
(Homo
sapiens)		5 / 12LEU A  16
ASN A  17
LEU A  19
ARG A  49
LEU A  72
None
1.23A15.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2W8Y_B_NDRB1000_0
(PROGESTERONE
RECEPTOR)		2pvc DNA
(CYTOSINE-5)-METHYLT
RANSFERASE 3-LIKE
(Homo
sapiens)		5 / 12LEU B 206
LEU B 203
MET B 283
LEU B 371
CYH B 367
None
1.38A22.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2W8Y_B_NDRB1000_0
(PROGESTERONE
RECEPTOR)		2z63 TOLL-LIKE RECEPTOR
4, VARIABLE
LYMPHOCYTE RECEPTOR
B
(Eptatretus
burgeri;
Homo
sapiens)		5 / 12LEU A 401
LEU A 421
LEU A 419
MET A 414
LEU A 427
None
1.49A18.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2W8Y_B_NDRB1000_0
(PROGESTERONE
RECEPTOR)		2z66 VARIABLE LYMPHOCYTE
RECEPTOR B,
TOLL-LIKE RECEPTOR 4
(Eptatretus
burgeri;
Homo
sapiens)		5 / 12LEU A 401
LEU A 421
LEU A 419
MET A 414
LEU A 427
None
1.47A26.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2W8Y_B_NDRB1000_0
(PROGESTERONE
RECEPTOR)		3eap RHO
GTPASE-ACTIVATING
PROTEIN 11A
(Homo
sapiens)		5 / 12LEU A  15
LEU A  12
LEU A   9
LEU A 137
CYH A 161
None
1.18A21.18
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2W8Y_B_NDRB1000_0
(PROGESTERONE
RECEPTOR)		3kba PROGESTERONE
RECEPTOR
(Homo
sapiens)		10 / 12LEU A 715
LEU A 718
ASN A 719
LEU A 721
GLN A 725
MET A 756
MET A 759
ARG A 766
MET A 801
CYH A 891
WOW  A   1 (-3.9A)
WOW  A   1 (-4.2A)
WOW  A   1 (-3.3A)
WOW  A   1 ( 4.3A)
WOW  A   1 ( 4.1A)
WOW  A   1 ( 4.1A)
WOW  A   1 (-3.7A)
WOW  A   1 (-3.8A)
WOW  A   1 (-4.2A)
WOW  A   1 (-3.5A)
0.55A100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2W8Y_B_NDRB1000_0
(PROGESTERONE
RECEPTOR)		3kba PROGESTERONE
RECEPTOR
(Homo
sapiens)		10 / 12LEU A 715
LEU A 718
ASN A 719
LEU A 721
MET A 756
MET A 759
ARG A 766
MET A 801
TYR A 890
CYH A 891
WOW  A   1 (-3.9A)
WOW  A   1 (-4.2A)
WOW  A   1 (-3.3A)
WOW  A   1 ( 4.3A)
WOW  A   1 ( 4.1A)
WOW  A   1 (-3.7A)
WOW  A   1 (-3.8A)
WOW  A   1 (-4.2A)
WOW  A   1 (-3.9A)
WOW  A   1 (-3.5A)
0.39A100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2W8Y_B_NDRB1000_0
(PROGESTERONE
RECEPTOR)		3kba PROGESTERONE
RECEPTOR
(Homo
sapiens)		5 / 12LEU A 715
LEU A 718
ASN A 719
MET A 759
MET A 801
WOW  A   1 (-3.9A)
WOW  A   1 (-4.2A)
WOW  A   1 (-3.3A)
WOW  A   1 (-3.7A)
WOW  A   1 (-4.2A)
1.46A100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2W8Y_B_NDRB1000_0
(PROGESTERONE
RECEPTOR)		3kba PROGESTERONE
RECEPTOR
(Homo
sapiens)		5 / 12LEU A 721
LEU A 718
LEU A 715
LEU A 763
MET A 801
WOW  A   1 ( 4.3A)
WOW  A   1 (-4.2A)
WOW  A   1 (-3.9A)
WOW  A   1 ( 4.0A)
WOW  A   1 (-4.2A)
1.15A100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2W8Y_B_NDRB1000_0
(PROGESTERONE
RECEPTOR)		3kn5 RIBOSOMAL PROTEIN S6
KINASE ALPHA-5
(Homo
sapiens)		5 / 12LEU A 676
LEU A 667
LEU A 668
LEU A 687
MET A 525
None
1.28A21.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2W8Y_B_NDRB1000_0
(PROGESTERONE
RECEPTOR)		4b99 MITOGEN-ACTIVATED
PROTEIN KINASE 7
(Homo
sapiens)		5 / 12LEU A 166
ASN A 113
LEU A 167
LEU A 144
MET A 255
None
1.23A19.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2W8Y_B_NDRB1000_0
(PROGESTERONE
RECEPTOR)		4byf UNCONVENTIONAL
MYOSIN-IC
(Homo
sapiens)		5 / 12LEU A 300
LEU A 303
LEU A 306
MET A 539
LEU A 318
None
1.49A17.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2W8Y_B_NDRB1000_0
(PROGESTERONE
RECEPTOR)		4fdh CYTOCHROME P450
11B2, MITOCHONDRIAL
(Homo
sapiens)		5 / 12LEU A 324
LEU A 327
LEU A 330
GLN A 337
ARG A 341
None
1.13A18.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2W8Y_B_NDRB1000_0
(PROGESTERONE
RECEPTOR)		4ol0 TRANSPORTIN-3
(Homo
sapiens)		5 / 12LEU B   8
LEU B  50
LEU B  51
MET B  67
LEU B  37
None
1.39A14.96
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2W8Y_B_NDRB1000_0
(PROGESTERONE
RECEPTOR)		4p6w GLUCOCORTICOID
RECEPTOR
(Homo
sapiens)		7 / 12ASN A 564
GLN A 570
MET A 601
ARG A 611
MET A 646
TYR A 735
CYH A 736
MOF  A 801 (-3.0A)
MOF  A 801 (-2.9A)
MOF  A 801 (-3.7A)
MOF  A 801 (-4.2A)
MOF  A 801 (-4.4A)
MOF  A 801 (-4.8A)
MOF  A 801 (-3.7A)
0.66A53.46
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2W8Y_B_NDRB1000_0
(PROGESTERONE
RECEPTOR)		4p6w GLUCOCORTICOID
RECEPTOR
(Homo
sapiens)		8 / 12LEU A 563
ASN A 564
LEU A 566
GLN A 570
MET A 601
ARG A 611
MET A 646
CYH A 736
MOF  A 801 (-3.9A)
MOF  A 801 (-3.0A)
MOF  A 801 ( 4.6A)
MOF  A 801 (-2.9A)
MOF  A 801 (-3.7A)
MOF  A 801 (-4.2A)
MOF  A 801 (-4.4A)
MOF  A 801 (-3.7A)
0.64A53.46
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2W8Y_B_NDRB1000_0
(PROGESTERONE
RECEPTOR)		4p6w GLUCOCORTICOID
RECEPTOR
(Homo
sapiens)		8 / 12LEU A 563
ASN A 564
LEU A 566
GLN A 570
MET A 601
MET A 604
ARG A 611
MET A 646
MOF  A 801 (-3.9A)
MOF  A 801 (-3.0A)
MOF  A 801 ( 4.6A)
MOF  A 801 (-2.9A)
MOF  A 801 (-3.7A)
None
MOF  A 801 (-4.2A)
MOF  A 801 (-4.4A)
0.86A53.46
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2W8Y_B_NDRB1000_0
(PROGESTERONE
RECEPTOR)		4p6w GLUCOCORTICOID
RECEPTOR
(Homo
sapiens)		5 / 12LEU A 566
LEU A 563
MET A 639
LEU A 608
MET A 646
MOF  A 801 ( 4.6A)
MOF  A 801 (-3.9A)
MOF  A 801 (-3.7A)
MOF  A 801 ( 4.6A)
MOF  A 801 (-4.4A)
1.29A53.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2W8Y_B_NDRB1000_0
(PROGESTERONE
RECEPTOR)		4red 5'-AMP-ACTIVATED
PROTEIN KINASE
CATALYTIC SUBUNIT
ALPHA-1
(Homo
sapiens)		5 / 12LEU A 113
LEU A 209
LEU A 206
LEU A 149
TYR A 106
None
1.49A22.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2W8Y_B_NDRB1000_0
(PROGESTERONE
RECEPTOR)		4roe TRANSCRIPTION FACTOR
IIIB 50 KDA SUBUNIT
(Homo
sapiens)		5 / 12LEU A 159
LEU A 160
LEU A 162
GLN A 128
LEU A 117
None
1.44A20.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2W8Y_B_NDRB1000_0
(PROGESTERONE
RECEPTOR)		4u1a ENOYL-COA DELTA
ISOMERASE 2
(Homo
sapiens)		5 / 12LEU A 188
LEU A 189
ASN A 185
LEU A 336
GLN A 242
 CL  A 401 ( 4.9A)
CL  A 401 ( 4.4A)
CL  A 401 ( 4.2A)
None
None
1.34A19.46
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2W8Y_B_NDRB1000_0
(PROGESTERONE
RECEPTOR)		4udb MINERALOCORTICOID
RECEPTOR
(Homo
sapiens)		5 / 12LEU A 766
ASN A 770
MET A 807
LEU A 848
CYH A 942
CV7  A1987 (-3.6A)
CV7  A1987 (-3.1A)
CV7  A1987 ( 3.9A)
CV7  A1987 ( 4.4A)
CV7  A1987 (-4.0A)
0.83A52.57
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2W8Y_B_NDRB1000_0
(PROGESTERONE
RECEPTOR)		4udb MINERALOCORTICOID
RECEPTOR
(Homo
sapiens)		9 / 12LEU A 766
LEU A 769
ASN A 770
LEU A 772
GLN A 776
MET A 807
ARG A 817
MET A 852
CYH A 942
CV7  A1987 (-3.6A)
CV7  A1987 (-4.1A)
CV7  A1987 (-3.1A)
CV7  A1987 ( 4.5A)
CV7  A1987 (-3.0A)
CV7  A1987 ( 3.9A)
CV7  A1987 (-3.7A)
CV7  A1987 ( 3.7A)
CV7  A1987 (-4.0A)
0.52A52.57
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2W8Y_B_NDRB1000_0
(PROGESTERONE
RECEPTOR)		4udb MINERALOCORTICOID
RECEPTOR
(Homo
sapiens)		5 / 12LEU A 772
LEU A 769
LEU A 766
LEU A 814
MET A 852
CV7  A1987 ( 4.5A)
CV7  A1987 (-4.1A)
CV7  A1987 (-3.6A)
CV7  A1987 ( 4.0A)
CV7  A1987 ( 3.7A)
1.27A52.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2W8Y_B_NDRB1000_0
(PROGESTERONE
RECEPTOR)		4y6o NAD-DEPENDENT
PROTEIN DEACETYLASE
SIRTUIN-2
(Homo
sapiens)		5 / 12LEU A 335
LEU A 329
GLN A 326
LEU A 258
MET A 260
None
1.29A25.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2W8Y_B_NDRB1000_0
(PROGESTERONE
RECEPTOR)		5dot CARBAMOYL-PHOSPHATE
SYNTHASE [AMMONIA],
MITOCHONDRIAL
(Homo
sapiens)		5 / 12LEU A 526
LEU A 520
GLN A 490
LEU A 426
MET A 462
None
1.48A10.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2W8Y_B_NDRB1000_0
(PROGESTERONE
RECEPTOR)		5hdh TOLL-LIKE RECEPTOR 8
(Homo
sapiens)		5 / 12LEU A 253
LEU A 294
LEU A 318
LEU A 289
MET A 310
None
1.48A16.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2W8Y_B_NDRB1000_0
(PROGESTERONE
RECEPTOR)		5hdh TOLL-LIKE RECEPTOR 8
(Homo
sapiens)		5 / 12LEU A 542
LEU A 561
ASN A 564
LEU A 591
LEU A 535
None
1.41A16.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2W8Y_B_NDRB1000_0
(PROGESTERONE
RECEPTOR)		5mwp MINERALOCORTICOID
RECEPTOR
(Homo
sapiens)		8 / 12LEU A 766
LEU A 769
ASN A 770
LEU A 772
GLN A 776
MET A 807
ARG A 817
CYH A 942
ECV  A1101 ( 3.9A)
ECV  A1101 (-4.7A)
ECV  A1101 (-3.1A)
ECV  A1101 ( 3.9A)
ECV  A1101 (-2.9A)
ECV  A1101 (-3.6A)
ECV  A1101 (-4.0A)
ECV  A1101 (-4.0A)
0.49Aundetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2W8Y_B_NDRB1000_0
(PROGESTERONE
RECEPTOR)		5mwp MINERALOCORTICOID
RECEPTOR
(Homo
sapiens)		5 / 12LEU A 772
GLN A 776
MET A 807
ARG A 817
MET A 852
ECV  A1101 ( 3.9A)
ECV  A1101 (-2.9A)
ECV  A1101 (-3.6A)
ECV  A1101 (-4.0A)
ECV  A1101 (-3.7A)
1.12Aundetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2W8Y_B_NDRB1000_0
(PROGESTERONE
RECEPTOR)		6el8 FORKHEAD BOX PROTEIN
N1
(Homo
sapiens)		5 / 12LEU A 322
ASN A 321
LEU A 278
MET A 354
CYH A 327
None
1.26A18.01