POTENTIAL TARGETS FROM HUMAN (RESULTS FROM SUB-STRUCTURAL SIMILARITY SEARCHES)1) User may click on the DrReposER ID (the second column) to get information on the binding sites and drug molecule.
2) Click View (the second last column) to view matched residues and superposition in the NGL viewer (upper right part).
3) User may also click on the Dock (the last column) to get script for molecular docking in UCSF Chimera through AutoDock Vina.

	DrReposER ID / Desc.	Hit PDBID	Hit Macromolecule	Res. Matches	Interface	HETATM	RMSD	Seq. Identity (%)	View	Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3B6H_A_MXDA551_1 (PROSTACYCLIN SYNTHASE)	1hzf	COMPLEMENT FACTOR C4A (Homo sapiens)	4 / 6	TYR A1248 ALA A1175 ALA A1124 THR A1123	None	0.92A	22.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3B6H_A_MXDA551_1 (PROSTACYCLIN SYNTHASE)	2a1a	INTERFERON-INDUCED, DOUBLE-STRANDED RNA-ACTIVATED PROTEIN KINASE (Homo sapiens)	4 / 6	TYR B 472 ALA B 473 LEU B 476 THR B 451	None	0.83A	20.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3B6H_A_MXDA551_1 (PROSTACYCLIN SYNTHASE)	2clp	AFLATOXIN B1 ALDEHYDE REDUCTASE MEMBER 3 (Homo sapiens)	4 / 6	TYR A 285 ALA A 289 ALA A 295 THR A 296	None	0.84A	19.77
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	3B6H_A_MXDA551_1 (PROSTACYCLIN SYNTHASE)	2iag	PROSTACYCLIN SYNTHASE (Homo sapiens)	4 / 6	ALA A 100 ALA A 283 THR A 284 ASN A 287	None HEM  A 600 (-4.4A) HEM  A 600 (-3.9A) HEM  A 600 (-4.2A)	0.64A	100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3B6H_A_MXDA551_1 (PROSTACYCLIN SYNTHASE)	2jbm	NICOTINATE-NUCLEOTID E PYROPHOSPHORYLASE (Homo sapiens)	4 / 6	ALA A 249 LEU A 223 ALA A 235 THR A 236	None	0.87A	21.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3B6H_A_MXDA551_1 (PROSTACYCLIN SYNTHASE)	3o3u	MALTOSE-BINDING PERIPLASMIC PROTEIN, ADVANCED GLYCOSYLATION END PRODUCT-SPECIFIC RECEPTOR (Escherichia coli; Homo sapiens)	4 / 6	ALA N 188 LEU N 192 ALA N 346 THR N 345	None	0.92A	22.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3B6H_A_MXDA551_1 (PROSTACYCLIN SYNTHASE)	3py7	MALTOSE-BINDING PERIPLASMIC PROTEIN,PAXILLIN LD1,PROTEIN E6 CHIMERA (Deltapapillomavi rus 4; Escherichia coli; Homo sapiens)	4 / 6	ALA A 189 LEU A 193 ALA A 347 THR A 346	None	0.92A	22.92
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	3B6H_A_MXDA551_1 (PROSTACYCLIN SYNTHASE)	3v8d	CHOLESTEROL 7-ALPHA-MONOOXYGENAS E (Homo sapiens)	4 / 6	ALA A 218 LEU A 219 ALA A 231 THR A 230	None	0.82A	36.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3B6H_A_MXDA551_1 (PROSTACYCLIN SYNTHASE)	4egc	MALTOSE-BINDING PERIPLASMIC PROTEIN, HOMEOBOX PROTEIN SIX1 CHIMERA (Escherichia coli; Homo sapiens)	4 / 6	ALA A 188 LEU A 192 ALA A 346 THR A 345	None	0.86A	21.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3B6H_A_MXDA551_1 (PROSTACYCLIN SYNTHASE)	4hwt	THREONINE--TRNA LIGASE, CYTOPLASMIC (Homo sapiens)	4 / 6	ALA A 388 LEU A 389 THR A 638 ASN A 640	None	0.92A	23.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3B6H_A_MXDA551_1 (PROSTACYCLIN SYNTHASE)	4llv	4E10 FV HEAVY CHAIN (Homo sapiens)	4 / 6	TYR A  32 ALA A  33 LEU A  34 ALA A  71	None	0.90A	14.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3B6H_A_MXDA551_1 (PROSTACYCLIN SYNTHASE)	4my2	MALTOSE-BINDING PERIPLASMIC PROTEIN, NORRIN FUSION PROTEIN (Escherichia coli; Homo sapiens)	4 / 6	ALA A 190 LEU A 194 ALA A 348 THR A 347	None	0.92A	22.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3B6H_A_MXDA551_1 (PROSTACYCLIN SYNTHASE)	4rwf	MALTOSE TRANSPORTER SUBUNIT, RECEPTOR ACTIVITY-MODIFYING PROTEIN 2, CALCITONIN GENE-RELATED PEPTIDE TYPE 1 RECEPTOR FUSION PROTEIN (Escherichia coli; Homo sapiens)	4 / 6	ALA A 190 LEU A 194 ALA A 348 THR A 347	None	0.89A	22.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3B6H_A_MXDA551_1 (PROSTACYCLIN SYNTHASE)	5a1n	BIFUNCTIONAL GLUTAMATE/PROLINE--T RNA LIGASE (Homo sapiens)	4 / 6	ALA A  20 LEU A  19 ALA A 126 THR A 127	None	0.89A	18.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3B6H_A_MXDA551_1 (PROSTACYCLIN SYNTHASE)	5hzv	MALTOSE-BINDING PERIPLASMIC PROTEIN,ENDOGLIN (Escherichia coli; Homo sapiens)	4 / 6	ALA A 555 LEU A 559 ALA A 713 THR A 712	None	0.92A	22.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3B6H_A_MXDA551_1 (PROSTACYCLIN SYNTHASE)	5jj4	MALTOSE-BINDING PERIPLASMIC PROTEIN,SINGLE-STRAN DED DNA CYTOSINE DEAMINASE (Escherichia coli; Homo sapiens)	4 / 6	ALA C 188 LEU C 192 ALA C 346 THR C 345	None	0.87A	22.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3B6H_B_MXDB551_1 (PROSTACYCLIN SYNTHASE)	2a1a	INTERFERON-INDUCED, DOUBLE-STRANDED RNA-ACTIVATED PROTEIN KINASE (Homo sapiens)	4 / 6	TYR B 472 ALA B 473 LEU B 476 THR B 451	None	0.82A	20.16
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	3B6H_B_MXDB551_1 (PROSTACYCLIN SYNTHASE)	2iag	PROSTACYCLIN SYNTHASE (Homo sapiens)	4 / 6	ALA A 100 ALA A 283 THR A 284 ASN A 287	None HEM  A 600 (-4.4A) HEM  A 600 (-3.9A) HEM  A 600 (-4.2A)	0.70A	100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3B6H_B_MXDB551_1 (PROSTACYCLIN SYNTHASE)	2jbm	NICOTINATE-NUCLEOTID E PYROPHOSPHORYLASE (Homo sapiens)	4 / 6	ALA A 249 LEU A 223 ALA A 235 THR A 236	None	0.89A	21.66
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	3B6H_B_MXDB551_1 (PROSTACYCLIN SYNTHASE)	3v8d	CHOLESTEROL 7-ALPHA-MONOOXYGENAS E (Homo sapiens)	4 / 6	ALA A 218 LEU A 219 ALA A 231 THR A 230	None	0.75A	36.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3B6H_B_MXDB551_1 (PROSTACYCLIN SYNTHASE)	4egc	MALTOSE-BINDING PERIPLASMIC PROTEIN, HOMEOBOX PROTEIN SIX1 CHIMERA (Escherichia coli; Homo sapiens)	4 / 6	ALA A 188 LEU A 192 ALA A 346 THR A 345	None	0.90A	21.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3B6H_B_MXDB551_1 (PROSTACYCLIN SYNTHASE)	4rwf	MALTOSE TRANSPORTER SUBUNIT, RECEPTOR ACTIVITY-MODIFYING PROTEIN 2, CALCITONIN GENE-RELATED PEPTIDE TYPE 1 RECEPTOR FUSION PROTEIN (Escherichia coli; Homo sapiens)	4 / 6	ALA A 190 LEU A 194 ALA A 348 THR A 347	None	0.91A	22.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3B6H_B_MXDB551_1 (PROSTACYCLIN SYNTHASE)	4zyo	ACYL-COA DESATURASE (Homo sapiens)	4 / 6	TYR A 254 ALA A 255 LEU A 258 ASN A  75	None None None ST9  A 403 (-3.4A)	0.88A	19.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3B6H_B_MXDB551_1 (PROSTACYCLIN SYNTHASE)	5a1n	BIFUNCTIONAL GLUTAMATE/PROLINE--T RNA LIGASE (Homo sapiens)	4 / 6	ALA A  20 LEU A  19 ALA A 126 THR A 127	None	0.89A	18.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3B6H_B_MXDB551_1 (PROSTACYCLIN SYNTHASE)	5jj4	MALTOSE-BINDING PERIPLASMIC PROTEIN,SINGLE-STRAN DED DNA CYTOSINE DEAMINASE (Escherichia coli; Homo sapiens)	4 / 6	ALA C 188 LEU C 192 ALA C 346 THR C 345	None	0.90A	22.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4K7A_A_MXDA1002_1 (ANDROGEN RECEPTOR)	1mi5	TCR ALPHA CHAIN TCR BETA CHAIN (Homo sapiens)	3 / 3	GLU E 132 TRP E 204 LYS D 132	None	1.49A	20.07
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	4K7A_A_MXDA1002_1 (ANDROGEN RECEPTOR)	2ax9	ANDROGEN RECEPTOR (Homo sapiens)	3 / 3	GLU A 793 TRP A 796 LYS A 861	None	0.34A	99.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4K7A_A_MXDA1002_1 (ANDROGEN RECEPTOR)	2b2y	CHROMODOMAIN-HELICAS E-DNA-BINDING PROTEIN 1 (Homo sapiens)	3 / 3	GLU C  14 TRP C  64 LYS C  11	None	1.50A	15.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4K7A_A_MXDA1002_1 (ANDROGEN RECEPTOR)	2ljf	INTEGRIN BETA-3 (Homo sapiens)	3 / 3	GLU A 726 TRP A 739 LYS A 729	None	1.47A	13.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4K7A_A_MXDA1002_1 (ANDROGEN RECEPTOR)	3d5e	PLATELET-ACTIVATING FACTOR ACETYLHYDROLASE (Homo sapiens)	3 / 3	GLU A 214 TRP A 298 LYS A 210	None DEP  A 473 (-3.7A) None	1.08A	20.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4K7A_A_MXDA1002_1 (ANDROGEN RECEPTOR)	4ewi	NACHT, LRR AND PYD DOMAINS-CONTAINING PROTEIN 4 (Homo sapiens)	3 / 3	GLU A  17 TRP A  13 LYS A  19	None	1.33A	19.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4K7A_A_MXDA1002_1 (ANDROGEN RECEPTOR)	5apa	ASPARTYL/ASPARAGINYL BETA-HYDROXYLASE (Homo sapiens)	3 / 3	GLU A 713 TRP A 594 LYS A 697	None	1.38A	19.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4K7A_A_MXDA1002_1 (ANDROGEN RECEPTOR)	6apj	ALPHA-N-ACETYLGALACT OSAMINIDE ALPHA-2,6-SIALYLTRAN SFERASE 2 (Homo sapiens)	3 / 3	GLU A 356 TRP A 360 LYS A 349	None	0.74A	16.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4K7A_A_MXDA1002_1 (ANDROGEN RECEPTOR)	6fuy	VINCULIN (Homo sapiens)	3 / 3	GLU A1042 TRP A 912 LYS A1047	None	1.42A	13.60