POTENTIAL TARGETS FROM HUMAN (RESULTS FROM SUB-STRUCTURAL SIMILARITY SEARCHES)
1) User may click on the DrReposER ID (the second column) to get information on the binding sites and drug molecule.
2) Click View (the second last column) to view matched residues and superposition in the NGL viewer (upper right part).
3) User may also click on the Dock (the last column) to get script for molecular docking in UCSF Chimera through AutoDock Vina.

DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MBS_A_MRVA1101_1
(CHIMERA PROTEIN OF
C-C CHEMOKINE
RECEPTOR TYPE 5 AND
RUBREDOXIN)		5b4w PLEXIN-B1
(Homo
sapiens)		5 / 12PHE A 218
PHE A 230
ILE A 184
TYR A 261
GLU A 263
None
1.20A20.94
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4MBS_A_MRVA1101_1
(CHIMERA PROTEIN OF
C-C CHEMOKINE
RECEPTOR TYPE 5 AND
RUBREDOXIN)		5t1a CHIMERA PROTEIN OF
CC CHEMOKINE
RECEPTOR TYPE 2
ISOFORM B AND
T4-LYSOZYME,LYSOZYME
(Escherichia
virus
T4;
Homo
sapiens)		5 / 12TYR A  49
TRP A  98
PHE A 194
TYR A 259
GLU A 291
73R  A1201 (-4.6A)
73R  A1201 (-3.6A)
None
None
73R  A1201 (-3.4A)
0.98A49.82
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4MBS_A_MRVA1101_1
(CHIMERA PROTEIN OF
C-C CHEMOKINE
RECEPTOR TYPE 5 AND
RUBREDOXIN)		5t1a CHIMERA PROTEIN OF
CC CHEMOKINE
RECEPTOR TYPE 2
ISOFORM B AND
T4-LYSOZYME,LYSOZYME
(Escherichia
virus
T4;
Homo
sapiens)		6 / 12TYR A  49
TRP A  98
TYR A 120
TRP A 256
TYR A 259
GLU A 291
73R  A1201 (-4.6A)
73R  A1201 (-3.6A)
73R  A1201 (-3.8A)
None
None
73R  A1201 (-3.4A)
0.55A49.82
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4MBS_A_MRVA1101_1
(CHIMERA PROTEIN OF
C-C CHEMOKINE
RECEPTOR TYPE 5 AND
RUBREDOXIN)		5uiw C-C CHEMOKINE
RECEPTOR TYPE
5,RUBREDOXIN CHIMERA
(Clostridium
pasteurianum;
Homo
sapiens)		9 / 12TYR A  37
TRP A  86
PHE A 109
PHE A 112
PHE A 182
ILE A 198
TRP A 248
TYR A 251
MET A 279
None
0.90A99.28
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4MBS_A_MRVA1101_1
(CHIMERA PROTEIN OF
C-C CHEMOKINE
RECEPTOR TYPE 5 AND
RUBREDOXIN)		5uiw C-C CHEMOKINE
RECEPTOR TYPE
5,RUBREDOXIN CHIMERA
(Clostridium
pasteurianum;
Homo
sapiens)		9 / 12TYR A  37
TRP A  86
PHE A 109
PHE A 112
PHE A 182
TRP A 248
TYR A 251
MET A 279
GLU A 283
None
0.98A99.28
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4MBS_A_MRVA1101_1
(CHIMERA PROTEIN OF
C-C CHEMOKINE
RECEPTOR TYPE 5 AND
RUBREDOXIN)		5uiw C-C CHEMOKINE
RECEPTOR TYPE
5,RUBREDOXIN CHIMERA
(Clostridium
pasteurianum;
Homo
sapiens)		9 / 12TYR A  37
TRP A  86
TYR A 108
PHE A 112
PHE A 182
ILE A 198
TRP A 248
TYR A 251
MET A 279
None
0.81A99.28
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4MBS_A_MRVA1101_1
(CHIMERA PROTEIN OF
C-C CHEMOKINE
RECEPTOR TYPE 5 AND
RUBREDOXIN)		5uiw C-C CHEMOKINE
RECEPTOR TYPE
5,RUBREDOXIN CHIMERA
(Clostridium
pasteurianum;
Homo
sapiens)		9 / 12TYR A  37
TRP A  86
TYR A 108
PHE A 112
PHE A 182
TRP A 248
TYR A 251
MET A 279
GLU A 283
None
0.93A99.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MBS_A_MRVA1101_2
(CHIMERA PROTEIN OF
C-C CHEMOKINE
RECEPTOR TYPE 5 AND
RUBREDOXIN)		1e51 DELTA-AMINOLEVULINIC
ACID DEHYDRATASE
(Homo
sapiens)		4 / 7GLN A 322
THR A 320
LEU A  31
THR A  24
None
1.14A21.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MBS_A_MRVA1101_2
(CHIMERA PROTEIN OF
C-C CHEMOKINE
RECEPTOR TYPE 5 AND
RUBREDOXIN)		2adb POLYPYRIMIDINE
TRACT-BINDING
PROTEIN 1
(Homo
sapiens)		4 / 7GLN A 223
LEU A 200
THR A 196
THR A 209
 C  B 301 ( 2.7A)
None
None
None
1.01A13.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MBS_A_MRVA1101_2
(CHIMERA PROTEIN OF
C-C CHEMOKINE
RECEPTOR TYPE 5 AND
RUBREDOXIN)		2b3x IRON-RESPONSIVE
ELEMENT BINDING
PROTEIN 1
(Homo
sapiens)		4 / 7GLN A 740
THR A 741
LEU A 669
THR A 677
None
0.85A18.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MBS_A_MRVA1101_2
(CHIMERA PROTEIN OF
C-C CHEMOKINE
RECEPTOR TYPE 5 AND
RUBREDOXIN)		2cde INKT-TCR
(Homo
sapiens)		4 / 7GLN A 109
THR A 108
LEU A  21
THR A  78
None
0.98A22.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MBS_A_MRVA1101_2
(CHIMERA PROTEIN OF
C-C CHEMOKINE
RECEPTOR TYPE 5 AND
RUBREDOXIN)		3ld8 BIFUNCTIONAL
ARGININE DEMETHYLASE
AND
LYSYL-HYDROXYLASE
JMJD6
(Homo
sapiens)		4 / 7TYR A 117
GLN A 286
THR A 264
THR A  86
None
1.07A19.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MBS_A_MRVA1101_2
(CHIMERA PROTEIN OF
C-C CHEMOKINE
RECEPTOR TYPE 5 AND
RUBREDOXIN)		3ww0 PROTEIN HIKESHI
(Homo
sapiens)		4 / 7GLN B  12
THR B  13
LEU B  41
THR B  74
None
1.07A17.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MBS_A_MRVA1101_2
(CHIMERA PROTEIN OF
C-C CHEMOKINE
RECEPTOR TYPE 5 AND
RUBREDOXIN)		5c41 RIBOKINASE
(Homo
sapiens)		4 / 7TYR A  99
THR A 174
LEU A 164
THR A 156
None
0.95A20.37
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4MBS_A_MRVA1101_2
(CHIMERA PROTEIN OF
C-C CHEMOKINE
RECEPTOR TYPE 5 AND
RUBREDOXIN)		5uiw C-C CHEMOKINE
RECEPTOR TYPE
5,RUBREDOXIN CHIMERA
(Clostridium
pasteurianum;
Homo
sapiens)		6 / 7TYR A  89
GLN A 194
THR A 195
LEU A 255
THR A 259
THR A 284
None
None
PCA  B   0 ( 4.3A)
None
None
OLC  A1107 ( 4.3A)
0.63A99.28
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4MBS_A_MRVA1101_2
(CHIMERA PROTEIN OF
C-C CHEMOKINE
RECEPTOR TYPE 5 AND
RUBREDOXIN)		5uiw C-C CHEMOKINE
RECEPTOR TYPE
5,RUBREDOXIN CHIMERA
(Clostridium
pasteurianum;
Homo
sapiens)		5 / 7TYR A  89
THR A 195
THR A 259
THR A 284
MET A 287
None
PCA  B   0 ( 4.3A)
None
OLC  A1107 ( 4.3A)
None
0.99A99.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MBS_A_MRVA1101_2
(CHIMERA PROTEIN OF
C-C CHEMOKINE
RECEPTOR TYPE 5 AND
RUBREDOXIN)		6fqc BIFUNCTIONAL
ARGININE DEMETHYLASE
AND
LYSYL-HYDROXYLASE
JMJD6
(Homo
sapiens)		4 / 7TYR A 117
GLN A 286
THR A 264
THR A  86
None
1.05A10.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MBS_B_MRVB1101_1
(CHIMERA PROTEIN OF
C-C CHEMOKINE
RECEPTOR TYPE 5 AND
RUBREDOXIN)		5b4w PLEXIN-B1
(Homo
sapiens)		5 / 12PHE A 218
PHE A 230
ILE A 184
TYR A 261
GLU A 263
None
1.23A20.94
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4MBS_B_MRVB1101_1
(CHIMERA PROTEIN OF
C-C CHEMOKINE
RECEPTOR TYPE 5 AND
RUBREDOXIN)		5t1a CHIMERA PROTEIN OF
CC CHEMOKINE
RECEPTOR TYPE 2
ISOFORM B AND
T4-LYSOZYME,LYSOZYME
(Escherichia
virus
T4;
Homo
sapiens)		5 / 12TYR A  49
TRP A  98
PHE A 194
THR A 267
GLU A 291
73R  A1201 (-4.6A)
73R  A1201 (-3.6A)
None
None
73R  A1201 (-3.4A)
1.00A49.82
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4MBS_B_MRVB1101_1
(CHIMERA PROTEIN OF
C-C CHEMOKINE
RECEPTOR TYPE 5 AND
RUBREDOXIN)		5t1a CHIMERA PROTEIN OF
CC CHEMOKINE
RECEPTOR TYPE 2
ISOFORM B AND
T4-LYSOZYME,LYSOZYME
(Escherichia
virus
T4;
Homo
sapiens)		7 / 12TYR A  49
TRP A  98
TYR A 120
TRP A 256
TYR A 259
THR A 267
GLU A 291
73R  A1201 (-4.6A)
73R  A1201 (-3.6A)
73R  A1201 (-3.8A)
None
None
None
73R  A1201 (-3.4A)
0.58A49.82
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4MBS_B_MRVB1101_1
(CHIMERA PROTEIN OF
C-C CHEMOKINE
RECEPTOR TYPE 5 AND
RUBREDOXIN)		5uiw C-C CHEMOKINE
RECEPTOR TYPE
5,RUBREDOXIN CHIMERA
(Clostridium
pasteurianum;
Homo
sapiens)		5 / 12PHE A 113
ILE A 198
TRP A 248
TYR A 251
THR A 259
None
1.46A99.28
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4MBS_B_MRVB1101_1
(CHIMERA PROTEIN OF
C-C CHEMOKINE
RECEPTOR TYPE 5 AND
RUBREDOXIN)		5uiw C-C CHEMOKINE
RECEPTOR TYPE
5,RUBREDOXIN CHIMERA
(Clostridium
pasteurianum;
Homo
sapiens)		9 / 12TYR A  37
TRP A  86
PHE A 109
PHE A 112
PHE A 182
ILE A 198
TRP A 248
TYR A 251
THR A 259
None
0.78A99.28
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4MBS_B_MRVB1101_1
(CHIMERA PROTEIN OF
C-C CHEMOKINE
RECEPTOR TYPE 5 AND
RUBREDOXIN)		5uiw C-C CHEMOKINE
RECEPTOR TYPE
5,RUBREDOXIN CHIMERA
(Clostridium
pasteurianum;
Homo
sapiens)		9 / 12TYR A  37
TRP A  86
PHE A 109
PHE A 112
PHE A 182
TRP A 248
TYR A 251
THR A 259
GLU A 283
None
0.95A99.28
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4MBS_B_MRVB1101_1
(CHIMERA PROTEIN OF
C-C CHEMOKINE
RECEPTOR TYPE 5 AND
RUBREDOXIN)		5uiw C-C CHEMOKINE
RECEPTOR TYPE
5,RUBREDOXIN CHIMERA
(Clostridium
pasteurianum;
Homo
sapiens)		9 / 12TYR A  37
TRP A  86
TYR A 108
PHE A 112
PHE A 182
ILE A 198
TRP A 248
TYR A 251
THR A 259
None
0.65A99.28
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4MBS_B_MRVB1101_1
(CHIMERA PROTEIN OF
C-C CHEMOKINE
RECEPTOR TYPE 5 AND
RUBREDOXIN)		5uiw C-C CHEMOKINE
RECEPTOR TYPE
5,RUBREDOXIN CHIMERA
(Clostridium
pasteurianum;
Homo
sapiens)		9 / 12TYR A  37
TRP A  86
TYR A 108
PHE A 112
PHE A 182
TRP A 248
TYR A 251
THR A 259
GLU A 283
None
0.87A99.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MBS_B_MRVB1101_2
(CHIMERA PROTEIN OF
C-C CHEMOKINE
RECEPTOR TYPE 5 AND
RUBREDOXIN)		1k6m 6-PHOSPHOFRUCTO-2-KI
NASE/FRUCTOSE-2,6-BI
PHOSPHATASE
2-PHOSPHATASE
(Homo
sapiens)		4 / 5TYR A  80
THR A  70
LEU A  65
THR A  55
None
None
None
AGS  A 503 (-3.3A)
1.44A23.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MBS_B_MRVB1101_2
(CHIMERA PROTEIN OF
C-C CHEMOKINE
RECEPTOR TYPE 5 AND
RUBREDOXIN)		1ua2 CELL DIVISION
PROTEIN KINASE 7
(Homo
sapiens)		4 / 5TYR A 294
THR A 228
LEU A 213
MET A 196
None
1.28A22.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MBS_B_MRVB1101_2
(CHIMERA PROTEIN OF
C-C CHEMOKINE
RECEPTOR TYPE 5 AND
RUBREDOXIN)		4b90 DIHYDROPYRIMIDINASE-
RELATED PROTEIN 5
(Homo
sapiens)		4 / 5TYR A 284
THR A 271
LEU A 310
THR A 304
None
1.47A19.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MBS_B_MRVB1101_2
(CHIMERA PROTEIN OF
C-C CHEMOKINE
RECEPTOR TYPE 5 AND
RUBREDOXIN)		4cgy DNA TOPOISOMERASE
3-ALPHA
(Homo
sapiens)		4 / 5THR A 423
LEU A 426
THR A 347
MET A 348
None
1.29A18.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MBS_B_MRVB1101_2
(CHIMERA PROTEIN OF
C-C CHEMOKINE
RECEPTOR TYPE 5 AND
RUBREDOXIN)		5c41 RIBOKINASE
(Homo
sapiens)		4 / 5TYR A  99
THR A 174
LEU A 164
THR A 156
None
0.93A20.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MBS_B_MRVB1101_2
(CHIMERA PROTEIN OF
C-C CHEMOKINE
RECEPTOR TYPE 5 AND
RUBREDOXIN)		5ddb MENIN
(Homo
sapiens)		4 / 5TYR A 361
LEU A 413
THR A 344
MET A 322
PG4  A 604 ( 4.6A)
None
None
59Q  A 601 (-4.4A)
1.48A21.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MBS_B_MRVB1101_2
(CHIMERA PROTEIN OF
C-C CHEMOKINE
RECEPTOR TYPE 5 AND
RUBREDOXIN)		5mju EXCITATORY AMINO
ACID TRANSPORTER
1,NEUTRAL AMINO ACID
TRANSPORTER
B(0),EXCITATORY
AMINO ACID
TRANSPORTER 1
(Homo
sapiens)		4 / 5THR A 367
LEU A 371
THR A 460
MET A 461
None
None
7O9  A 602 (-3.3A)
None
1.48A23.21
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4MBS_B_MRVB1101_2
(CHIMERA PROTEIN OF
C-C CHEMOKINE
RECEPTOR TYPE 5 AND
RUBREDOXIN)		5uiw C-C CHEMOKINE
RECEPTOR TYPE
5,RUBREDOXIN CHIMERA
(Clostridium
pasteurianum;
Homo
sapiens)		4 / 5TYR A  89
THR A 195
LEU A 255
THR A 284
None
PCA  B   0 ( 4.3A)
None
OLC  A1107 ( 4.3A)
0.62A99.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MBS_B_MRVB1101_2
(CHIMERA PROTEIN OF
C-C CHEMOKINE
RECEPTOR TYPE 5 AND
RUBREDOXIN)		5w5j RECEPTOR-INTERACTING
SERINE/THREONINE-PRO
TEIN KINASE 2
(Homo
sapiens)		4 / 5TYR A 113
THR A  95
LEU A  79
THR A 149
None
9WS  A 401 (-3.2A)
9WS  A 401 (-4.9A)
None
1.39A20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MBS_B_MRVB1101_2
(CHIMERA PROTEIN OF
C-C CHEMOKINE
RECEPTOR TYPE 5 AND
RUBREDOXIN)		6bq1 PHOSPHATIDYLINOSITOL
4-KINASE III ALPHA
(PI4KA)
(Homo
sapiens)		4 / 5TYR A1532
THR A1381
LEU A1353
THR A1412
None
1.41A0.00