POTENTIAL TARGETS FROM HUMAN (RESULTS FROM SUB-STRUCTURAL SIMILARITY SEARCHES)
1) User may click on the DrReposER ID (the second column) to get information on the binding sites and drug molecule.
2) Click View (the second last column) to view matched residues and superposition in the NGL viewer (upper right part).
3) User may also click on the Dock (the last column) to get script for molecular docking in UCSF Chimera through AutoDock Vina.

DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FFY_A_MRCA1993_1
(ISOLEUCYL-TRNA
SYNTHETASE)		1qh5 PROTEIN
(HYDROXYACYLGLUTATHI
ONE HYDROLASE)
(Homo
sapiens)		5 / 12PRO A  30
GLY A 133
ASP A 134
PHE A 137
VAL A 138
None
None
ZN  A 262 ( 2.4A)
GSH  A 463 (-4.9A)
None
1.03A14.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FFY_A_MRCA1993_1
(ISOLEUCYL-TRNA
SYNTHETASE)		2b5m DAMAGE-SPECIFIC DNA
BINDING PROTEIN 1
(Homo
sapiens)		5 / 12ASN A 211
GLY A 187
ASP A 184
GLN A 186
VAL A 181
None
1.12A22.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FFY_A_MRCA1993_1
(ISOLEUCYL-TRNA
SYNTHETASE)		2pfi CHLORIDE CHANNEL
PROTEIN CLC-KA
(Homo
sapiens)		5 / 12GLY A 666
ASN A 552
SER A 573
PHE A 657
VAL A 658
None
1.22A11.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FFY_A_MRCA1993_1
(ISOLEUCYL-TRNA
SYNTHETASE)		2qk4 TRIFUNCTIONAL PURINE
BIOSYNTHETIC PROTEIN
ADENOSINE-3
(Homo
sapiens)		5 / 12GLY A 371
ASN A  36
GLY A  12
ASP A 295
VAL A 386
None
1.18A19.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FFY_A_MRCA1993_1
(ISOLEUCYL-TRNA
SYNTHETASE)		4bqm GLUTAMINASE LIVER
ISOFORM,
MITOCHONDRIAL
(Homo
sapiens)		5 / 12PRO A 223
HIS A 239
GLY A 243
ASN A 264
GLY A 270
None
None
None
EDO  A1467 (-3.5A)
None
1.15A15.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FFY_A_MRCA1993_1
(ISOLEUCYL-TRNA
SYNTHETASE)		4o7d GLUTAMINASE KIDNEY
ISOFORM,
MITOCHONDRIAL
(Homo
sapiens)		5 / 12PRO A 290
HIS A 306
GLY A 310
ASN A 331
GLY A 337
None
1.14A15.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FFY_A_MRCA1993_1
(ISOLEUCYL-TRNA
SYNTHETASE)		5d3o GLUTAMINASE KIDNEY
ISOFORM,
MITOCHONDRIAL
(Homo
sapiens)		5 / 12PRO A 295
HIS A 311
GLY A 315
ASN A 336
GLY A 342
None
1.22A21.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FFY_A_MRCA1993_1
(ISOLEUCYL-TRNA
SYNTHETASE)		5ekd TRYPTOPHAN--TRNA
LIGASE,
MITOCHONDRIAL
(Homo
sapiens)		5 / 12GLY A  50
GLY A 179
ASP A 181
GLN A 182
VAL A 217
ATP  A 402 (-3.6A)
ATP  A 402 (-3.0A)
ATP  A 402 (-2.9A)
5BX  A 401 ( 3.0A)
ATP  A 402 (-3.3A)
0.83A17.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FFY_A_MRCA1993_1
(ISOLEUCYL-TRNA
SYNTHETASE)		5ekd TRYPTOPHAN--TRNA
LIGASE,
MITOCHONDRIAL
(Homo
sapiens)		5 / 12HIS A  48
GLY A  50
GLY A 179
ASP A 181
VAL A 217
ATP  A 402 (-4.0A)
ATP  A 402 (-3.6A)
ATP  A 402 (-3.0A)
ATP  A 402 (-2.9A)
ATP  A 402 (-3.3A)
0.78A17.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FFY_A_MRCA1993_1
(ISOLEUCYL-TRNA
SYNTHETASE)		5uqe GLUTAMINASE KIDNEY
ISOFORM,
MITOCHONDRIAL
(Homo
sapiens)		5 / 12PRO A 290
HIS A 306
GLY A 310
ASN A 331
GLY A 337
None
1.30A21.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FFY_A_MRCA1993_2
(ISOLEUCYL-TRNA
SYNTHETASE)		1b47 CBL
(Homo
sapiens)		4 / 6PRO A 214
HIS A 213
TRP A 202
GLU A 220
None
1.37A16.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FFY_A_MRCA1993_2
(ISOLEUCYL-TRNA
SYNTHETASE)		3pta DNA
(CYTOSINE-5)-METHYLT
RANSFERASE 1
(Homo
sapiens)		4 / 6PRO A1375
HIS A1412
TRP A1519
GLU A1376
None
1.50A21.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JZS_A_MRCA1301_1
(ISOLEUCYL-TRNA
SYNTHETASE)		1r6u TRYPTOPHANYL-TRNA
SYNTHETASE
(Homo
sapiens)		5 / 11GLY A 161
HIS A 170
HIS A 173
ASP A 312
GLN A 313
TYM  A 501 (-3.6A)
None
TYM  A 501 (-4.6A)
TYM  A 501 (-3.2A)
TYM  A 501 (-3.6A)
0.94A19.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JZS_A_MRCA1301_1
(ISOLEUCYL-TRNA
SYNTHETASE)		2pid TYROSYL-TRNA
SYNTHETASE
(Homo
sapiens)		6 / 11GLY A  79
HIS A  88
HIS A  91
GLY A 244
ASP A 246
GLN A 247
YSA  A 384 (-3.2A)
None
YSA  A 384 (-4.1A)
YSA  A 384 (-2.5A)
YSA  A 384 (-3.3A)
YSA  A 384 (-3.2A)
0.65A18.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JZS_A_MRCA1301_1
(ISOLEUCYL-TRNA
SYNTHETASE)		2pid TYROSYL-TRNA
SYNTHETASE
(Homo
sapiens)		6 / 11GLY A  79
HIS A  91
GLY A 244
ASP A 246
GLN A 247
ILE A 274
YSA  A 384 (-3.2A)
YSA  A 384 (-4.1A)
YSA  A 384 (-2.5A)
YSA  A 384 (-3.3A)
YSA  A 384 (-3.2A)
YSA  A 384 (-4.4A)
0.57A18.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JZS_A_MRCA1301_1
(ISOLEUCYL-TRNA
SYNTHETASE)		2qcm URIDINE
5'-MONOPHOSPHATE
SYNTHASE (UMP
SYNTHASE)
(Homo
sapiens)		5 / 11GLY A 418
SER A 373
GLY A 450
ASP A 259
ILE A 277
JW5  A 482 ( 4.9A)
None
JW5  A 482 (-3.4A)
JW5  A 482 (-2.9A)
None
1.24A16.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JZS_A_MRCA1301_1
(ISOLEUCYL-TRNA
SYNTHETASE)		5ekd TRYPTOPHAN--TRNA
LIGASE,
MITOCHONDRIAL
(Homo
sapiens)		5 / 11GLY A  40
HIS A  48
GLY A 179
ASP A 181
GLN A 182
5BX  A 401 (-3.9A)
ATP  A 402 (-4.0A)
ATP  A 402 (-3.0A)
ATP  A 402 (-2.9A)
5BX  A 401 ( 3.0A)
0.84A17.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JZS_A_MRCA1301_1
(ISOLEUCYL-TRNA
SYNTHETASE)		6apj ALPHA-N-ACETYLGALACT
OSAMINIDE
ALPHA-2,6-SIALYLTRAN
SFERASE 2
(Homo
sapiens)		5 / 11GLY A 166
PRO A 167
HIS A 172
GLN A 165
LEU A 371
None
1.14A8.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JZS_A_MRCA1301_1
(ISOLEUCYL-TRNA
SYNTHETASE)		6cbp DH270.6 SINGLE CHAIN
VARIABLE FRAGMENT
MAN9-V3 GLYCOPEPTIDE
(Homo
sapiens;
Human
immunodeficiency
virus
1)		5 / 11GLY A 237
HIS A  35
SER A 173
GLY P 324
ASP A 107
NAG  P 401 (-3.7A)
None
None
None
None
1.11A7.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JZS_A_MRCA1301_1
(ISOLEUCYL-TRNA
SYNTHETASE)		6eoq DIPEPTIDYL PEPTIDASE
9
(Homo
sapiens)		5 / 11GLY A 686
HIS A 424
GLU A 495
GLN A 684
ILE A 504
None
1.22A8.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QU2_A_MRCA1993_1
(ISOLEUCYL-TRNA
SYNTHETASE)		1p1v SUPEROXIDE DISMUTASE
[CU-ZN]
(Homo
sapiens)		5 / 12GLY A  82
HIS A  80
GLY A  85
ASP A 124
VAL A  47
None
ZN  A 202 (-3.0A)
None
None
None
1.11A10.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QU2_A_MRCA1993_1
(ISOLEUCYL-TRNA
SYNTHETASE)		1qh5 PROTEIN
(HYDROXYACYLGLUTATHI
ONE HYDROLASE)
(Homo
sapiens)		5 / 12PRO A  30
GLY A 133
ASP A 134
PHE A 137
VAL A 138
None
None
ZN  A 262 ( 2.4A)
GSH  A 463 (-4.9A)
None
1.03A14.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QU2_A_MRCA1993_1
(ISOLEUCYL-TRNA
SYNTHETASE)		2pid TYROSYL-TRNA
SYNTHETASE
(Homo
sapiens)		5 / 12GLY A  90
HIS A  91
GLY A 244
ASP A 246
GLN A 247
YSA  A 384 (-3.5A)
YSA  A 384 (-4.1A)
YSA  A 384 (-2.5A)
YSA  A 384 (-3.3A)
YSA  A 384 (-3.2A)
0.57A18.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QU2_A_MRCA1993_1
(ISOLEUCYL-TRNA
SYNTHETASE)		2pid TYROSYL-TRNA
SYNTHETASE
(Homo
sapiens)		5 / 12HIS A  88
GLY A  90
HIS A  91
GLY A 244
ASP A 246
None
YSA  A 384 (-3.5A)
YSA  A 384 (-4.1A)
YSA  A 384 (-2.5A)
YSA  A 384 (-3.3A)
0.85A18.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QU2_A_MRCA1993_1
(ISOLEUCYL-TRNA
SYNTHETASE)		4zaj ARGININE--TRNA
LIGASE, CYTOPLASMIC
(Homo
sapiens)		5 / 12HIS A 136
GLY A 138
HIS A 139
GLN A 340
VAL A 372
None
0.56A21.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QU2_A_MRCA1993_1
(ISOLEUCYL-TRNA
SYNTHETASE)		5ekd TRYPTOPHAN--TRNA
LIGASE,
MITOCHONDRIAL
(Homo
sapiens)		5 / 12GLY A  50
GLY A 179
ASP A 181
GLN A 182
VAL A 217
ATP  A 402 (-3.6A)
ATP  A 402 (-3.0A)
ATP  A 402 (-2.9A)
5BX  A 401 ( 3.0A)
ATP  A 402 (-3.3A)
0.83A17.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QU2_A_MRCA1993_1
(ISOLEUCYL-TRNA
SYNTHETASE)		5ekd TRYPTOPHAN--TRNA
LIGASE,
MITOCHONDRIAL
(Homo
sapiens)		5 / 12HIS A  48
GLY A  50
GLY A 179
ASP A 181
VAL A 217
ATP  A 402 (-4.0A)
ATP  A 402 (-3.6A)
ATP  A 402 (-3.0A)
ATP  A 402 (-2.9A)
ATP  A 402 (-3.3A)
0.78A17.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QU2_A_MRCA1993_2
(ISOLEUCYL-TRNA
SYNTHETASE)		1ex0 COAGULATION FACTOR
XIII A CHAIN
(Homo
sapiens)		3 / 3GLU A 377
TRP A 392
LYS A 504
None
1.32A23.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QU2_A_MRCA1993_2
(ISOLEUCYL-TRNA
SYNTHETASE)		2k2o MYOFERLIN
(Homo
sapiens)		3 / 3GLU A 994
TRP A1008
LYS A 918
None
1.29A9.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QU2_A_MRCA1993_2
(ISOLEUCYL-TRNA
SYNTHETASE)		2wd9 ACYL-COENZYME A
SYNTHETASE ACSM2A,
MITOCHONDRIAL
(Homo
sapiens)		3 / 3GLU A 503
TRP A 568
LYS A 141
None
1.39A19.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QU2_A_MRCA1993_2
(ISOLEUCYL-TRNA
SYNTHETASE)		3l2j FUSION PROTEIN OF
MALTOSE-BINDING
PERIPLASMIC PROTEIN
AND PARATHYROID
HORMONE/PARATHYROID
HORMONE-RELATED
PEPTIDE RECEPTOR
(Escherichia
coli;
Homo
sapiens)		3 / 3GLU A-233
TRP A-114
LYS A -71
MAL  A 194 (-2.9A)
MAL  A 194 ( 4.6A)
None
1.20A21.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QU2_A_MRCA1993_2
(ISOLEUCYL-TRNA
SYNTHETASE)		3szb ALDEHYDE
DEHYDROGENASE
(Homo
sapiens)		3 / 3GLU A  61
TRP A  56
LYS A 137
None
1.26A19.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QU2_A_MRCA1993_2
(ISOLEUCYL-TRNA
SYNTHETASE)		3vd8 MALTOSE-BINDING
PERIPLASMIC PROTEIN,
INTERFERON-INDUCIBLE
PROTEIN AIM2
(Escherichia
coli;
Homo
sapiens)		3 / 3GLU A 111
TRP A 230
LYS A 273
MTT  A1205 (-2.9A)
MTT  A1205 (-4.3A)
None
1.29A19.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QU2_A_MRCA1993_2
(ISOLEUCYL-TRNA
SYNTHETASE)		4ikm MALTOSE-BINDING
PERIPLASMIC PROTEIN,
CASPASE RECRUITMENT
DOMAIN-CONTAINING
PROTEIN 8
(Escherichia
coli;
Homo
sapiens)		3 / 3GLU A 112
TRP A 231
LYS A 274
MAL  A 501 (-2.9A)
MAL  A 501 ( 4.6A)
None
1.31A20.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QU2_A_MRCA1993_2
(ISOLEUCYL-TRNA
SYNTHETASE)		4my2 MALTOSE-BINDING
PERIPLASMIC PROTEIN,
NORRIN FUSION
PROTEIN
(Escherichia
coli;
Homo
sapiens)		3 / 3GLU A 113
TRP A 232
LYS A 275
MAL  A1201 (-3.1A)
MAL  A1201 ( 4.6A)
None
1.20A20.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QU2_A_MRCA1993_2
(ISOLEUCYL-TRNA
SYNTHETASE)		4wrn MALTOSE-BINDING
PERIPLASMIC
PROTEIN,UROMODULIN
(Escherichia
coli;
Homo
sapiens)		3 / 3GLU A 135
TRP A 254
LYS A 297
MAL  A 801 (-2.8A)
MAL  A 801 ( 3.6A)
None
1.05A21.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QU2_A_MRCA1993_2
(ISOLEUCYL-TRNA
SYNTHETASE)		5a31 ANAPHASE-PROMOTING
COMPLEX SUBUNIT 1
ANAPHASE-PROMOTING
COMPLEX SUBUNIT 2
(Homo
sapiens)		3 / 3GLU A1782
TRP A1674
LYS N 320
None
1.36A20.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QU2_A_MRCA1993_2
(ISOLEUCYL-TRNA
SYNTHETASE)		5a31 ANAPHASE-PROMOTING
COMPLEX SUBUNIT 1
ANAPHASE-PROMOTING
COMPLEX SUBUNIT 5
(Homo
sapiens)		3 / 3GLU A  91
TRP A 128
LYS O 573
None
1.32A20.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QU2_A_MRCA1993_2
(ISOLEUCYL-TRNA
SYNTHETASE)		5hzv MALTOSE-BINDING
PERIPLASMIC
PROTEIN,ENDOGLIN
(Escherichia
coli;
Homo
sapiens)		3 / 3GLU A 478
TRP A 597
LYS A 640
MAL  A1001 (-3.1A)
MAL  A1001 (-4.8A)
None
1.18A21.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QU2_A_MRCA1993_2
(ISOLEUCYL-TRNA
SYNTHETASE)		5tj2 SUGAR ABC
TRANSPORTER
SUBSTRATE-BINDING
PROTEIN,GASDERMIN-B
FUSION PROTEIN
(Escherichia
coli;
Homo
sapiens)		3 / 3GLU A 111
TRP A 230
LYS A 273
MAL  A1501 (-3.0A)
MAL  A1501 ( 4.6A)
None
1.20A20.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QU2_A_MRCA1993_2
(ISOLEUCYL-TRNA
SYNTHETASE)		6ei1 ZINC FINGER WITH
UFM1-SPECIFIC
PEPTIDASE DOMAIN
PROTEIN
(Homo
sapiens)		3 / 3GLU A 428
TRP A 401
LYS A 481
None
1.42A7.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QU3_A_MRCA993_1
(ISOLEUCYL-TRNA
SYNTHETASE)		2pfi CHLORIDE CHANNEL
PROTEIN CLC-KA
(Homo
sapiens)		5 / 12GLY A 666
ASN A 552
SER A 573
PHE A 657
VAL A 658
None
1.28A11.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QU3_A_MRCA993_1
(ISOLEUCYL-TRNA
SYNTHETASE)		2pid TYROSYL-TRNA
SYNTHETASE
(Homo
sapiens)		5 / 12HIS A  88
GLY A  90
HIS A  91
ASP A 246
GLN A 247
None
YSA  A 384 (-3.5A)
YSA  A 384 (-4.1A)
YSA  A 384 (-3.3A)
YSA  A 384 (-3.2A)
0.95A18.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QU3_A_MRCA993_1
(ISOLEUCYL-TRNA
SYNTHETASE)		3x05 PHOSPHATIDYLINOSITOL
5-PHOSPHATE 4-KINASE
TYPE-2 BETA
(Homo
sapiens)		5 / 12GLY A  49
HIS A  52
GLN A 118
PHE A  36
VAL A  45
None
1.49A18.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QU3_A_MRCA993_1
(ISOLEUCYL-TRNA
SYNTHETASE)		4c6o CAD PROTEIN
(Homo
sapiens)		5 / 12HIS A1647
GLY A1665
GLU A1592
GLN A1593
VAL A1670
None
1.02A18.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QU3_A_MRCA993_1
(ISOLEUCYL-TRNA
SYNTHETASE)		4r3z ARGININE--TRNA
LIGASE, CYTOPLASMIC
(Homo
sapiens)		5 / 12HIS B 208
GLY B 210
GLN B 412
VAL B 444
LYS B 451
None
1.15A22.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QU3_A_MRCA993_1
(ISOLEUCYL-TRNA
SYNTHETASE)		4r3z ARGININE--TRNA
LIGASE, CYTOPLASMIC
(Homo
sapiens)		5 / 12HIS B 208
GLY B 210
HIS B 211
VAL B 444
LYS B 451
None
1.19A22.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QU3_A_MRCA993_1
(ISOLEUCYL-TRNA
SYNTHETASE)		4zaj ARGININE--TRNA
LIGASE, CYTOPLASMIC
(Homo
sapiens)		6 / 12HIS A 136
GLY A 138
HIS A 139
GLN A 340
VAL A 372
LYS A 379
None
0.83A21.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QU3_A_MRCA993_1
(ISOLEUCYL-TRNA
SYNTHETASE)		5h1u TRANSCRIPTION
INTERMEDIARY FACTOR
1-ALPHA
(Homo
sapiens)		5 / 12GLY B 835
HIS B 849
ASN B 834
SER B 921
GLN B 833
None
ZN  B1103 (-3.2A)
None
None
None
1.50A12.50