POTENTIAL TARGETS FROM HUMAN (RESULTS FROM SUB-STRUCTURAL SIMILARITY SEARCHES)
1) User may click on the DrReposER ID (the second column) to get information on the binding sites and drug molecule.
2) Click View (the second last column) to view matched residues and superposition in the NGL viewer (upper right part).
3) User may also click on the Dock (the last column) to get script for molecular docking in UCSF Chimera through AutoDock Vina.

DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5M8N_A_MMSA514_1
(5,6-DIHYDROXYINDOLE-
2-CARBOXYLIC ACID
OXIDASE)		1kcw CERULOPLASMIN
(Homo
sapiens)		5 / 10HIS A 637
ASN A 632
LEU A 322
THR A 564
SER A 629
 CU  A1053 ( 3.1A)
None
None
None
None
1.32A19.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5M8N_A_MMSA514_1
(5,6-DIHYDROXYINDOLE-
2-CARBOXYLIC ACID
OXIDASE)		1kcw CERULOPLASMIN
(Homo
sapiens)		5 / 10HIS A1020
HIS A 980
TYR A 107
HIS A 103
HIS A 161
 CU  A1050 (-3.2A)
CU  A1050 (-3.0A)
None
CU  A1051 (-3.3A)
CU  A1051 (-3.3A)
1.23A19.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5M8N_A_MMSA514_1
(5,6-DIHYDROXYINDOLE-
2-CARBOXYLIC ACID
OXIDASE)		2i7t CLEAVAGE AND
POLYADENYLATION
SPECIFICITY FACTOR
73 KDA SUBUNIT
(Homo
sapiens)		5 / 10HIS A 396
HIS A 418
HIS A  71
HIS A  73
LEU A  74
SO4  A 491 (-4.0A)
ZN  A 481 ( 3.4A)
ZN  A 482 (-3.5A)
ZN  A 482 ( 3.2A)
None
1.32A21.60
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5M8N_A_MMSA514_1
(5,6-DIHYDROXYINDOLE-
2-CARBOXYLIC ACID
OXIDASE)		5m8t 5,6-DIHYDROXYINDOLE-
2-CARBOXYLIC ACID
OXIDASE
(Homo
sapiens)		7 / 10HIS A 192
HIS A 215
HIS A 377
ASN A 378
HIS A 381
LEU A 382
SER A 394
 ZN  A 512 ( 3.3A)
ZN  A 512 ( 3.3A)
ZN  A 511 ( 3.2A)
0TR  A 513 ( 4.4A)
ZN  A 511 ( 3.3A)
None
0TR  A 513 (-3.2A)
0.14A99.33
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5M8N_A_MMSA514_1
(5,6-DIHYDROXYINDOLE-
2-CARBOXYLIC ACID
OXIDASE)		5m8t 5,6-DIHYDROXYINDOLE-
2-CARBOXYLIC ACID
OXIDASE
(Homo
sapiens)		5 / 10HIS A 381
HIS A 404
HIS A 215
HIS A 192
SER A 394
 ZN  A 511 ( 3.3A)
ZN  A 511 (-3.1A)
ZN  A 512 ( 3.3A)
ZN  A 512 ( 3.3A)
0TR  A 513 (-3.2A)
1.37A99.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5M8N_B_MMSB515_1
(5,6-DIHYDROXYINDOLE-
2-CARBOXYLIC ACID
OXIDASE)		1kcw CERULOPLASMIN
(Homo
sapiens)		5 / 10HIS A1020
HIS A 980
TYR A 107
HIS A 103
HIS A 161
 CU  A1050 (-3.2A)
CU  A1050 (-3.0A)
None
CU  A1051 (-3.3A)
CU  A1051 (-3.3A)
1.36A19.12
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5M8N_B_MMSB515_1
(5,6-DIHYDROXYINDOLE-
2-CARBOXYLIC ACID
OXIDASE)		5m8t 5,6-DIHYDROXYINDOLE-
2-CARBOXYLIC ACID
OXIDASE
(Homo
sapiens)		7 / 10HIS A 192
HIS A 215
HIS A 377
ASN A 378
HIS A 381
LEU A 382
SER A 394
 ZN  A 512 ( 3.3A)
ZN  A 512 ( 3.3A)
ZN  A 511 ( 3.2A)
0TR  A 513 ( 4.4A)
ZN  A 511 ( 3.3A)
None
0TR  A 513 (-3.2A)
0.13A99.33
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5M8N_B_MMSB515_1
(5,6-DIHYDROXYINDOLE-
2-CARBOXYLIC ACID
OXIDASE)		5m8t 5,6-DIHYDROXYINDOLE-
2-CARBOXYLIC ACID
OXIDASE
(Homo
sapiens)		5 / 10HIS A 381
HIS A 404
HIS A 215
HIS A 192
SER A 394
 ZN  A 511 ( 3.3A)
ZN  A 511 (-3.1A)
ZN  A 512 ( 3.3A)
ZN  A 512 ( 3.3A)
0TR  A 513 (-3.2A)
1.40A99.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5M8N_C_MMSC516_1
(5,6-DIHYDROXYINDOLE-
2-CARBOXYLIC ACID
OXIDASE)		1kcw CERULOPLASMIN
(Homo
sapiens)		5 / 9HIS A1020
HIS A 980
TYR A 107
HIS A 103
HIS A 161
 CU  A1050 (-3.2A)
CU  A1050 (-3.0A)
None
CU  A1051 (-3.3A)
CU  A1051 (-3.3A)
1.26A19.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5M8N_C_MMSC516_1
(5,6-DIHYDROXYINDOLE-
2-CARBOXYLIC ACID
OXIDASE)		3wv6 GALECTIN-9
(Homo
sapiens)		5 / 9HIS A 188
HIS A 320
TYR A 144
ASN A  34
THR A 319
 ZN  A 401 (-3.2A)
ZN  A 401 (-3.2A)
None
EDO  A 407 (-3.5A)
EDO  A 406 ( 3.0A)
1.46A21.85
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5M8N_C_MMSC516_1
(5,6-DIHYDROXYINDOLE-
2-CARBOXYLIC ACID
OXIDASE)		5m8t 5,6-DIHYDROXYINDOLE-
2-CARBOXYLIC ACID
OXIDASE
(Homo
sapiens)		6 / 9HIS A 192
HIS A 215
HIS A 377
ASN A 378
HIS A 381
SER A 394
 ZN  A 512 ( 3.3A)
ZN  A 512 ( 3.3A)
ZN  A 511 ( 3.2A)
0TR  A 513 ( 4.4A)
ZN  A 511 ( 3.3A)
0TR  A 513 (-3.2A)
0.19A99.33
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5M8N_C_MMSC516_1
(5,6-DIHYDROXYINDOLE-
2-CARBOXYLIC ACID
OXIDASE)		5m8t 5,6-DIHYDROXYINDOLE-
2-CARBOXYLIC ACID
OXIDASE
(Homo
sapiens)		5 / 9HIS A 381
HIS A 404
HIS A 215
HIS A 192
SER A 394
 ZN  A 511 ( 3.3A)
ZN  A 511 (-3.1A)
ZN  A 512 ( 3.3A)
ZN  A 512 ( 3.3A)
0TR  A 513 (-3.2A)
1.35A99.33
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5M8N_D_MMSD515_1
(5,6-DIHYDROXYINDOLE-
2-CARBOXYLIC ACID
OXIDASE)		5m8t 5,6-DIHYDROXYINDOLE-
2-CARBOXYLIC ACID
OXIDASE
(Homo
sapiens)		6 / 9HIS A 215
HIS A 377
ASN A 378
HIS A 381
LEU A 382
SER A 394
 ZN  A 512 ( 3.3A)
ZN  A 511 ( 3.2A)
0TR  A 513 ( 4.4A)
ZN  A 511 ( 3.3A)
None
0TR  A 513 (-3.2A)
0.30A99.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5M8R_A_MMSA511_1
(5,6-DIHYDROXYINDOLE-
2-CARBOXYLIC ACID
OXIDASE)		1bkd SON OF SEVENLESS-1
(Homo
sapiens)		4 / 7HIS S 695
HIS S 700
LEU S 640
VAL S 624
None
1.01A22.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5M8R_A_MMSA511_1
(5,6-DIHYDROXYINDOLE-
2-CARBOXYLIC ACID
OXIDASE)		1jd0 CARBONIC ANHYDRASE
XII
(Homo
sapiens)		4 / 7HIS A  96
HIS A 119
LEU A 118
VAL A 121
 ZN  A 901 ( 3.2A)
ZN  A 901 ( 3.1A)
None
AZM  A1400 (-4.6A)
1.05A20.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5M8R_A_MMSA511_1
(5,6-DIHYDROXYINDOLE-
2-CARBOXYLIC ACID
OXIDASE)		1xdv SON OF SEVENLESS
PROTEIN HOMOLOG 1
(Homo
sapiens)		4 / 7HIS A 695
HIS A 700
LEU A 640
VAL A 624
None
1.01A19.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5M8R_A_MMSA511_1
(5,6-DIHYDROXYINDOLE-
2-CARBOXYLIC ACID
OXIDASE)		2gk1 BETA-HEXOSAMINIDASE
SUBUNIT ALPHA
(Homo
sapiens)		4 / 7HIS I 204
HIS I 202
HIS I 318
LEU I 317
None
0.95A20.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5M8R_A_MMSA511_1
(5,6-DIHYDROXYINDOLE-
2-CARBOXYLIC ACID
OXIDASE)		3ml5 CARBONIC ANHYDRASE 7
(Homo
sapiens)		4 / 7HIS A  96
HIS A 119
LEU A 118
VAL A 121
 ZN  A 263 ( 3.2A)
ZN  A 263 ( 3.1A)
None
AZM  A 264 (-4.7A)
1.04A21.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5M8R_A_MMSA511_1
(5,6-DIHYDROXYINDOLE-
2-CARBOXYLIC ACID
OXIDASE)		4qk3 CARBONIC ANHYDRASE 2
(Homo
sapiens)		4 / 7HIS A  96
HIS A 119
LEU A 118
VAL A 121
 ZN  A 301 (-3.2A)
ZN  A 301 (-3.1A)
None
None
1.07A21.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5M8R_A_MMSA511_1
(5,6-DIHYDROXYINDOLE-
2-CARBOXYLIC ACID
OXIDASE)		4wjl INACTIVE DIPEPTIDYL
PEPTIDASE 10
(Homo
sapiens)		4 / 7HIS A 581
LEU A 575
VAL A 596
SER A 550
None
0.92A20.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5M8R_A_MMSA511_1
(5,6-DIHYDROXYINDOLE-
2-CARBOXYLIC ACID
OXIDASE)		5cjf CARBONIC ANHYDRASE
14
(Homo
sapiens)		4 / 7HIS A  96
HIS A 119
LEU A 118
VAL A 121
 ZN  A 301 ( 3.2A)
ZN  A 301 ( 3.1A)
None
520  A 302 ( 4.9A)
1.06A20.40
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5M8R_A_MMSA511_1
(5,6-DIHYDROXYINDOLE-
2-CARBOXYLIC ACID
OXIDASE)		5m8t 5,6-DIHYDROXYINDOLE-
2-CARBOXYLIC ACID
OXIDASE
(Homo
sapiens)		7 / 7HIS A 215
HIS A 377
ASN A 378
HIS A 381
LEU A 382
VAL A 391
SER A 394
 ZN  A 512 ( 3.3A)
ZN  A 511 ( 3.2A)
0TR  A 513 ( 4.4A)
ZN  A 511 ( 3.3A)
None
0TR  A 513 (-3.8A)
0TR  A 513 (-3.2A)
0.25A100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5M8R_A_MMSA511_1
(5,6-DIHYDROXYINDOLE-
2-CARBOXYLIC ACID
OXIDASE)		6b3e CYCLIN-DEPENDENT
KINASE 12
(Homo
sapiens)		4 / 7HIS A 818
LEU A 820
VAL A 829
SER A 826
None
1.04A10.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5M8R_B_MMSB514_1
(5,6-DIHYDROXYINDOLE-
2-CARBOXYLIC ACID
OXIDASE)		1nmw PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE
NIMA-INTERACTING 1
(Homo
sapiens)		4 / 8SER A 147
HIS A  59
HIS A 157
VAL A  62
None
0.95A14.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5M8R_B_MMSB514_1
(5,6-DIHYDROXYINDOLE-
2-CARBOXYLIC ACID
OXIDASE)		2gjx BETA-HEXOSAMINIDASE
ALPHA CHAIN
(Homo
sapiens)		4 / 8HIS A 204
HIS A 202
HIS A 318
LEU A 317
None
0.96A20.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5M8R_B_MMSB514_1
(5,6-DIHYDROXYINDOLE-
2-CARBOXYLIC ACID
OXIDASE)		2gk1 BETA-HEXOSAMINIDASE
SUBUNIT ALPHA
(Homo
sapiens)		4 / 8HIS I 204
HIS I 202
HIS I 318
LEU I 317
None
0.91A20.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5M8R_B_MMSB514_1
(5,6-DIHYDROXYINDOLE-
2-CARBOXYLIC ACID
OXIDASE)		4cq1 POLYPYRIMIDINE
TRACT-BINDING
PROTEIN 2
(Homo
sapiens)		4 / 8SER A 454
HIS A 458
LEU A 457
SER A 460
None
0.92A19.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5M8R_B_MMSB514_1
(5,6-DIHYDROXYINDOLE-
2-CARBOXYLIC ACID
OXIDASE)		4wjl INACTIVE DIPEPTIDYL
PEPTIDASE 10
(Homo
sapiens)		4 / 8HIS A 581
LEU A 575
VAL A 596
SER A 550
None
0.96A20.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5M8R_B_MMSB514_1
(5,6-DIHYDROXYINDOLE-
2-CARBOXYLIC ACID
OXIDASE)		5hdh TOLL-LIKE RECEPTOR 8
(Homo
sapiens)		4 / 8HIS A 593
ASN A 590
LEU A 613
SER A 647
None
NAG  A 912 (-2.4A)
None
None
1.02A19.43
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5M8R_B_MMSB514_1
(5,6-DIHYDROXYINDOLE-
2-CARBOXYLIC ACID
OXIDASE)		5m8t 5,6-DIHYDROXYINDOLE-
2-CARBOXYLIC ACID
OXIDASE
(Homo
sapiens)		8 / 8HIS A 215
SER A 374
HIS A 377
ASN A 378
HIS A 381
LEU A 382
VAL A 391
SER A 394
 ZN  A 512 ( 3.3A)
None
ZN  A 511 ( 3.2A)
0TR  A 513 ( 4.4A)
ZN  A 511 ( 3.3A)
None
0TR  A 513 (-3.8A)
0TR  A 513 (-3.2A)
0.42A100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5M8R_B_MMSB514_1
(5,6-DIHYDROXYINDOLE-
2-CARBOXYLIC ACID
OXIDASE)		5m8t 5,6-DIHYDROXYINDOLE-
2-CARBOXYLIC ACID
OXIDASE
(Homo
sapiens)		4 / 8HIS A 381
HIS A 215
HIS A 224
LEU A 221
 ZN  A 511 ( 3.3A)
ZN  A 512 ( 3.3A)
ZN  A 512 (-3.5A)
None
0.94A100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5M8R_C_MMSC516_1
(5,6-DIHYDROXYINDOLE-
2-CARBOXYLIC ACID
OXIDASE)		2i7t CLEAVAGE AND
POLYADENYLATION
SPECIFICITY FACTOR
73 KDA SUBUNIT
(Homo
sapiens)		4 / 8HIS A  73
HIS A 396
GLY A 157
VAL A 159
 ZN  A 482 ( 3.2A)
SO4  A 491 (-4.0A)
None
None
0.99A21.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5M8R_C_MMSC516_1
(5,6-DIHYDROXYINDOLE-
2-CARBOXYLIC ACID
OXIDASE)		2ifg HIGH AFFINITY NERVE
GROWTH FACTOR
RECEPTOR
(Homo
sapiens)		4 / 8HIS A 343
LEU A 333
GLY A 344
SER A 304
None
0.89A23.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5M8R_C_MMSC516_1
(5,6-DIHYDROXYINDOLE-
2-CARBOXYLIC ACID
OXIDASE)		3bg9 PYRUVATE
CARBOXYLASE,
MITOCHONDRIAL
(Homo
sapiens)		4 / 8HIS A 771
HIS A 773
GLY A 868
SER A 576
 MN  A2001 (-3.4A)
MN  A2001 (-3.8A)
None
None
0.88A19.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5M8R_C_MMSC516_1
(5,6-DIHYDROXYINDOLE-
2-CARBOXYLIC ACID
OXIDASE)		3ml5 CARBONIC ANHYDRASE 7
(Homo
sapiens)		4 / 8HIS A  96
HIS A 119
LEU A 118
VAL A 121
 ZN  A 263 ( 3.2A)
ZN  A 263 ( 3.1A)
None
AZM  A 264 (-4.7A)
1.01A21.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5M8R_C_MMSC516_1
(5,6-DIHYDROXYINDOLE-
2-CARBOXYLIC ACID
OXIDASE)		4qk3 CARBONIC ANHYDRASE 2
(Homo
sapiens)		4 / 8HIS A  96
LEU A 118
GLY A 145
VAL A 143
 ZN  A 301 (-3.2A)
None
None
None
1.03A21.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5M8R_C_MMSC516_1
(5,6-DIHYDROXYINDOLE-
2-CARBOXYLIC ACID
OXIDASE)		4wjl INACTIVE DIPEPTIDYL
PEPTIDASE 10
(Homo
sapiens)		4 / 8HIS A 581
LEU A 575
VAL A 596
SER A 550
None
0.93A20.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5M8R_C_MMSC516_1
(5,6-DIHYDROXYINDOLE-
2-CARBOXYLIC ACID
OXIDASE)		5cjf CARBONIC ANHYDRASE
14
(Homo
sapiens)		4 / 8HIS A  96
HIS A 119
LEU A 118
VAL A 121
 ZN  A 301 ( 3.2A)
ZN  A 301 ( 3.1A)
None
520  A 302 ( 4.9A)
1.03A20.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5M8R_C_MMSC516_1
(5,6-DIHYDROXYINDOLE-
2-CARBOXYLIC ACID
OXIDASE)		5fn4 GAMMA-SECRETASE
SUBUNIT APH-1A
(Homo
sapiens)		4 / 8HIS C 197
HIS C 171
GLY C 126
SER C 129
None
0.98A20.37
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5M8R_C_MMSC516_1
(5,6-DIHYDROXYINDOLE-
2-CARBOXYLIC ACID
OXIDASE)		5m8t 5,6-DIHYDROXYINDOLE-
2-CARBOXYLIC ACID
OXIDASE
(Homo
sapiens)		8 / 8HIS A 215
HIS A 377
ASN A 378
HIS A 381
LEU A 382
GLY A 389
VAL A 391
SER A 394
 ZN  A 512 ( 3.3A)
ZN  A 511 ( 3.2A)
0TR  A 513 ( 4.4A)
ZN  A 511 ( 3.3A)
None
0TR  A 513 (-3.8A)
0TR  A 513 (-3.8A)
0TR  A 513 (-3.2A)
0.29A100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5M8R_C_MMSC516_1
(5,6-DIHYDROXYINDOLE-
2-CARBOXYLIC ACID
OXIDASE)		5m8t 5,6-DIHYDROXYINDOLE-
2-CARBOXYLIC ACID
OXIDASE
(Homo
sapiens)		4 / 8HIS A 215
HIS A 377
HIS A 381
GLY A 388
 ZN  A 512 ( 3.3A)
ZN  A 511 ( 3.2A)
ZN  A 511 ( 3.3A)
None
0.88A100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5M8R_D_MMSD509_1
(5,6-DIHYDROXYINDOLE-
2-CARBOXYLIC ACID
OXIDASE)		1bkd SON OF SEVENLESS-1
(Homo
sapiens)		4 / 8HIS S 695
HIS S 700
LEU S 640
VAL S 624
None
1.00A22.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5M8R_D_MMSD509_1
(5,6-DIHYDROXYINDOLE-
2-CARBOXYLIC ACID
OXIDASE)		1jd0 CARBONIC ANHYDRASE
XII
(Homo
sapiens)		4 / 8HIS A  96
HIS A 119
LEU A 118
VAL A 121
 ZN  A 901 ( 3.2A)
ZN  A 901 ( 3.1A)
None
AZM  A1400 (-4.6A)
1.01A20.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5M8R_D_MMSD509_1
(5,6-DIHYDROXYINDOLE-
2-CARBOXYLIC ACID
OXIDASE)		1nmw PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE
NIMA-INTERACTING 1
(Homo
sapiens)		4 / 8SER A 147
HIS A  59
HIS A 157
VAL A  62
None
0.96A14.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5M8R_D_MMSD509_1
(5,6-DIHYDROXYINDOLE-
2-CARBOXYLIC ACID
OXIDASE)		1xdv SON OF SEVENLESS
PROTEIN HOMOLOG 1
(Homo
sapiens)		4 / 8HIS A 695
HIS A 700
LEU A 640
VAL A 624
None
1.00A19.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5M8R_D_MMSD509_1
(5,6-DIHYDROXYINDOLE-
2-CARBOXYLIC ACID
OXIDASE)		2gk1 BETA-HEXOSAMINIDASE
SUBUNIT ALPHA
(Homo
sapiens)		4 / 8HIS I 204
HIS I 202
HIS I 318
LEU I 317
None
0.91A20.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5M8R_D_MMSD509_1
(5,6-DIHYDROXYINDOLE-
2-CARBOXYLIC ACID
OXIDASE)		3ml5 CARBONIC ANHYDRASE 7
(Homo
sapiens)		4 / 8HIS A  96
HIS A 119
LEU A 118
VAL A 121
 ZN  A 263 ( 3.2A)
ZN  A 263 ( 3.1A)
None
AZM  A 264 (-4.7A)
0.98A21.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5M8R_D_MMSD509_1
(5,6-DIHYDROXYINDOLE-
2-CARBOXYLIC ACID
OXIDASE)		4cq1 POLYPYRIMIDINE
TRACT-BINDING
PROTEIN 2
(Homo
sapiens)		4 / 8SER A 454
HIS A 458
LEU A 457
SER A 460
None
0.93A19.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5M8R_D_MMSD509_1
(5,6-DIHYDROXYINDOLE-
2-CARBOXYLIC ACID
OXIDASE)		4n40 PROTEIN ECT2
(Homo
sapiens)		4 / 8SER A 136
HIS A 170
LEU A 140
VAL A 168
None
0.95A19.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5M8R_D_MMSD509_1
(5,6-DIHYDROXYINDOLE-
2-CARBOXYLIC ACID
OXIDASE)		4wjl INACTIVE DIPEPTIDYL
PEPTIDASE 10
(Homo
sapiens)		4 / 8HIS A 581
LEU A 575
VAL A 596
SER A 550
None
0.97A20.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5M8R_D_MMSD509_1
(5,6-DIHYDROXYINDOLE-
2-CARBOXYLIC ACID
OXIDASE)		5cjf CARBONIC ANHYDRASE
14
(Homo
sapiens)		4 / 8HIS A  96
HIS A 119
LEU A 118
VAL A 121
 ZN  A 301 ( 3.2A)
ZN  A 301 ( 3.1A)
None
520  A 302 ( 4.9A)
1.01A20.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5M8R_D_MMSD509_1
(5,6-DIHYDROXYINDOLE-
2-CARBOXYLIC ACID
OXIDASE)		5hdh TOLL-LIKE RECEPTOR 8
(Homo
sapiens)		4 / 8HIS A 593
ASN A 590
LEU A 613
SER A 647
None
NAG  A 912 (-2.4A)
None
None
1.01A19.43
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5M8R_D_MMSD509_1
(5,6-DIHYDROXYINDOLE-
2-CARBOXYLIC ACID
OXIDASE)		5m8t 5,6-DIHYDROXYINDOLE-
2-CARBOXYLIC ACID
OXIDASE
(Homo
sapiens)		8 / 8HIS A 215
SER A 374
HIS A 377
ASN A 378
HIS A 381
LEU A 382
VAL A 391
SER A 394
 ZN  A 512 ( 3.3A)
None
ZN  A 511 ( 3.2A)
0TR  A 513 ( 4.4A)
ZN  A 511 ( 3.3A)
None
0TR  A 513 (-3.8A)
0TR  A 513 (-3.2A)
0.37A100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5M8R_D_MMSD509_1
(5,6-DIHYDROXYINDOLE-
2-CARBOXYLIC ACID
OXIDASE)		5m8t 5,6-DIHYDROXYINDOLE-
2-CARBOXYLIC ACID
OXIDASE
(Homo
sapiens)		4 / 8HIS A 381
HIS A 215
HIS A 224
LEU A 221
 ZN  A 511 ( 3.3A)
ZN  A 512 ( 3.3A)
ZN  A 512 (-3.5A)
None
0.93A100.00