POTENTIAL TARGETS FROM HUMAN (RESULTS FROM SUB-STRUCTURAL SIMILARITY SEARCHES)1) User may click on the DrReposER ID (the second column) to get information on the binding sites and drug molecule.
2) Click View (the second last column) to view matched residues and superposition in the NGL viewer (upper right part).
3) User may also click on the Dock (the last column) to get script for molecular docking in UCSF Chimera through AutoDock Vina.

	DrReposER ID / Desc.	Hit PDBID	Hit Macromolecule	Res. Matches	Interface	HETATM	RMSD	Seq. Identity (%)	View	Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1DWC_H_MITH1_1 (ALPHA-THROMBIN (LARGE SUBUNIT))	1elv	COMPLEMENT C1S COMPONENT (Homo sapiens)	5 / 9	HIS A 460 ASP A 611 SER A 617 TRP A 640 GLY A 648	SO4  A2001 ( 3.9A) None SO4  A2001 ( 2.7A) None None	0.45A	28.29
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	1DWC_H_MITH1_1 (ALPHA-THROMBIN (LARGE SUBUNIT))	1fxy	COAGULATION FACTOR XA-TRYPSIN CHIMERA (Homo sapiens)	5 / 9	HIS A  57 ASP A 189 SER A 195 TRP A 215 GLY A 226	0G6  A   1 (-2.7A) 0G6  A   1 (-2.8A) 0G6  A   1 (-1.4A) None 0G6  A   1 (-3.3A)	0.56A	37.21
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	1DWC_H_MITH1_1 (ALPHA-THROMBIN (LARGE SUBUNIT))	1h4w	TRYPSIN IVA (Homo sapiens)	5 / 9	HIS A  57 ASP A 189 SER A 195 TRP A 215 GLY A 226	None BEN  A 250 (-2.9A) BEN  A 250 (-3.6A) None BEN  A 250 (-3.3A)	0.33A	37.21
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	1DWC_H_MITH1_1 (ALPHA-THROMBIN (LARGE SUBUNIT))	1o5f	SERINE PROTEASE HEPSIN (Homo sapiens)	5 / 9	HIS H  57 ASP H 189 SER H 195 TRP H 215 GLY H 226	CR9  H 256 (-3.9A) CR9  H 256 (-2.4A) CR9  H 256 (-1.5A) None CR9  H 256 (-3.0A)	0.45A	40.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1DWC_H_MITH1_1 (ALPHA-THROMBIN (LARGE SUBUNIT))	1q3x	MANNAN-BINDING LECTIN SERINE PROTEASE 2 (Homo sapiens)	5 / 9	HIS A 483 ASP A 627 SER A 633 TRP A 655 GLY A 667	None NA  A 800 ( 4.6A) GOL  A 701 (-3.0A) None GOL  A 701 ( 4.0A)	0.39A	28.95
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	1DWC_H_MITH1_1 (ALPHA-THROMBIN (LARGE SUBUNIT))	1zlr	COAGULATION FACTOR XI (Homo sapiens)	5 / 9	HIS A  57 ASP A 189 SER A 195 TRP A 215 GLY A 226	368  A 901 (-4.0A) 368  A 901 (-2.8A) 368  A 901 (-1.4A) None 368  A 901 (-3.5A)	0.28A	37.02
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	1DWC_H_MITH1_1 (ALPHA-THROMBIN (LARGE SUBUNIT))	2ei8	COAGULATION FACTOR X, HEAVY CHAIN (Homo sapiens)	5 / 9	HIS A  57 ASP A 189 SER A 195 TRP A 215 GLY A 226	None DT8  A 700 (-3.5A) DT8  A 700 ( 3.9A) DT8  A 700 (-3.9A) DT8  A 700 (-3.5A)	0.46A	40.77
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	1DWC_H_MITH1_1 (ALPHA-THROMBIN (LARGE SUBUNIT))	2oq5	TRANSMEMBRANE PROTEASE, SERINE 11E (Homo sapiens)	5 / 9	HIS A  57 ASP A 189 SER A 195 TRP A 215 GLY A 226	None BEN  A 245 (-3.0A) BEN  A 245 (-3.3A) None BEN  A 245 (-3.4A)	0.40A	37.31
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	1DWC_H_MITH1_1 (ALPHA-THROMBIN (LARGE SUBUNIT))	2pks	THROMBIN HEAVY CHAIN FRAGMENT (Homo sapiens)	5 / 9	ILE C 209 ASP C 229 SER C 235 TRP C 257 GLY C 268	G44  C 101 (-3.9A) G44  C 101 (-2.6A) G44  C 101 (-3.5A) G44  C 101 (-4.1A) G44  C 101 (-3.0A)	0.40A	100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	1DWC_H_MITH1_1 (ALPHA-THROMBIN (LARGE SUBUNIT))	2psy	KALLIKREIN-5 (Homo sapiens)	5 / 9	HIS A  57 ASP A 189 SER A 195 TRP A 215 GLY A 226	None	0.55A	34.87
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	1DWC_H_MITH1_1 (ALPHA-THROMBIN (LARGE SUBUNIT))	2qy0	COMPLEMENT C1R SUBCOMPONENT (Homo sapiens)	5 / 9	HIS B 485 ASP B 631 SER B 637 TRP B 659 GLY B 668	None	0.27A	38.15
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	1DWC_H_MITH1_1 (ALPHA-THROMBIN (LARGE SUBUNIT))	2r0l	HEPATOCYTE GROWTH FACTOR ACTIVATOR (Homo sapiens)	5 / 9	HIS A  57 ASP A 189 SER A 195 TRP A 215 GLY A 226	None	0.30A	35.07
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	1DWC_H_MITH1_1 (ALPHA-THROMBIN (LARGE SUBUNIT))	2wpm	COAGULATION FACTOR IXA HEAVY CHAIN (Homo sapiens)	5 / 9	HIS S  57 ASP S 189 SER S 195 TRP S 215 GLY S 226	None	0.57A	37.74
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	1DWC_H_MITH1_1 (ALPHA-THROMBIN (LARGE SUBUNIT))	2zec	TRYPTASE BETA 2 (Homo sapiens)	5 / 9	HIS A  59 ASP A 203 SER A 209 TRP A 229 GLY A 240	None 11N  A   1 (-2.6A) 11N  A   1 (-3.3A) None 11N  A   1 (-3.6A)	0.43A	35.69
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	1DWC_H_MITH1_1 (ALPHA-THROMBIN (LARGE SUBUNIT))	3f6u	VITAMIN K-DEPENDENT PROTEIN C HEAVY CHAIN (Homo sapiens)	5 / 9	HIS H  57 ASP H 189 SER H 195 TRP H 215 GLY H 226	0G6  H   1 (-3.2A) 0G6  H   1 (-2.8A) 0G6  H   1 (-1.8A) 0G6  H   1 (-4.1A) 0G6  H   1 ( 3.9A)	0.54A	40.23
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	1DWC_H_MITH1_1 (ALPHA-THROMBIN (LARGE SUBUNIT))	3gov	MASP-1 (Homo sapiens)	5 / 9	HIS B 490 ASP B 640 SER B 646 TRP B 668 GLY B 679	None	0.39A	36.56
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	1DWC_H_MITH1_1 (ALPHA-THROMBIN (LARGE SUBUNIT))	3gym	PROSTASIN (Homo sapiens)	5 / 9	HIS A  57 ASP A 189 SER A 195 TRP A 215 GLY A 226	None	0.53A	36.56
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	1DWC_H_MITH1_1 (ALPHA-THROMBIN (LARGE SUBUNIT))	3nxp	PRETHROMBIN-1 (Homo sapiens)	5 / 9	HIS A 457 TYR A 460 ILE A 574 SER A 595 GLY A 626	None	0.85A	100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	1DWC_H_MITH1_1 (ALPHA-THROMBIN (LARGE SUBUNIT))	3r3g	THROMBIN HEAVY CHAIN (Homo sapiens)	6 / 9	HIS B  57 TYR B  60 ILE B 174 ASP B 189 GLU B 192 SER B 195	None	0.83A	97.68
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	1DWC_H_MITH1_1 (ALPHA-THROMBIN (LARGE SUBUNIT))	3r3g	THROMBIN HEAVY CHAIN (Homo sapiens)	7 / 9	HIS B  57 TYR B  60 ILE B 174 ASP B 189 SER B 195 TRP B 215 GLY B 226	None	0.39A	97.68
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	1DWC_H_MITH1_1 (ALPHA-THROMBIN (LARGE SUBUNIT))	3r3g	THROMBIN HEAVY CHAIN (Homo sapiens)	5 / 9	TYR B  60 TRP B  60 ILE B 174 ASP B 189 TRP B 215	None	0.83A	97.68
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	1DWC_H_MITH1_1 (ALPHA-THROMBIN (LARGE SUBUNIT))	4iw4	MANNAN-BINDING LECTIN SERINE PROTEASE 3 (Homo sapiens)	5 / 9	HIS E 478 ASP E 639 SER E 645 TRP E 667 GLY E 680	None	0.70A	35.17
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	1DWC_H_MITH1_1 (ALPHA-THROMBIN (LARGE SUBUNIT))	4r0i	SUPPRESSOR OF TUMORIGENICITY 14 PROTEIN (Homo sapiens)	5 / 9	HIS A  57 ASP A 189 SER A 195 TRP A 215 GLY A 226	3KM  A 900 ( 4.4A) 3KM  A 900 (-2.9A) 3KM  A 900 (-3.6A) None 3KM  A 900 (-3.2A)	0.42A	35.50
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	1DWC_H_MITH1_1 (ALPHA-THROMBIN (LARGE SUBUNIT))	4wwy	TRYPSIN-1 (Homo sapiens)	5 / 9	HIS A  57 ASP A 189 SER A 195 TRP A 215 GLY A 226	None	0.48A	36.43
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	1DWC_H_MITH1_1 (ALPHA-THROMBIN (LARGE SUBUNIT))	4ylq	COAGULATION FACTOR VII (Homo sapiens)	5 / 9	HIS H  57 ASP H 189 SER H 195 TRP H 215 GLY H 226	0Z7  H 501 (-2.6A) 0Z7  H 501 (-2.3A) 0Z7  H 501 (-1.4A) TMA  H 508 ( 3.9A) 0Z7  H 501 (-3.0A)	0.49A	35.74
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	1DWC_H_MITH1_1 (ALPHA-THROMBIN (LARGE SUBUNIT))	5f8z	PLASMA KALLIKREIN LIGHT CHAIN (Homo sapiens)	5 / 9	HIS A  57 ASP A 189 SER A 195 TRP A 215 GLY A 226	None	0.45A	39.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1DWC_H_MITH1_1 (ALPHA-THROMBIN (LARGE SUBUNIT))	5ms3	KALLIKREIN-8 (Homo sapiens)	5 / 9	HIS A  57 ASP A 189 SER A 195 TRP A 215 GLY A 226	None	0.45A	17.70
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	1DWC_H_MITH1_1 (ALPHA-THROMBIN (LARGE SUBUNIT))	5to3	PROTHROMBIN,THROMBOM ODULIN (Homo sapiens)	6 / 9	HIS B  58 TYR B  62 ILE B 194 ASP B 214 SER B 220 GLY B 253	0G6  B 501 (-2.5A) 0G6  B 501 (-3.7A) None 0G6  B 501 (-2.9A) 0G6  B 501 (-1.3A) 0G6  B 501 (-3.6A)	0.40A	88.62
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	1DWC_H_MITH1_1 (ALPHA-THROMBIN (LARGE SUBUNIT))	5to3	PROTHROMBIN,THROMBOM ODULIN (Homo sapiens)	5 / 9	TYR B  62 ILE B 194 ASP B 214 GLU B 217 GLY B 253	0G6  B 501 (-3.7A) None 0G6  B 501 (-2.9A) 0G6  B 501 (-3.8A) 0G6  B 501 (-3.6A)	1.01A	88.62
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	1DWC_H_MITH1_1 (ALPHA-THROMBIN (LARGE SUBUNIT))	5to3	PROTHROMBIN,THROMBOM ODULIN (Homo sapiens)	5 / 9	TYR B  62 TRP B  65 ILE B 194 ASP B 214 GLY B 253	0G6  B 501 (-3.7A) 0G6  B 501 (-4.8A) None 0G6  B 501 (-2.9A) 0G6  B 501 (-3.6A)	0.80A	88.62
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	1DWC_H_MITH1_1 (ALPHA-THROMBIN (LARGE SUBUNIT))	5ubm	COMPLEMENT C1S SUBCOMPONENT (Homo sapiens)	5 / 9	HIS A 475 ASP A 626 SER A 632 TRP A 655 GLY A 663	None	0.55A	35.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1DWC_H_MITH1_1 (ALPHA-THROMBIN (LARGE SUBUNIT))	6b74	COAGULATION FACTOR XII (Homo sapiens)	5 / 9	HIS B  57 ASP B 189 SER B 195 TRP B 215 GLY B 226	SO4  B 304 (-3.8A) BEN  B 301 (-2.7A) SO4  B 304 ( 2.5A) None BEN  B 301 (-3.1A)	0.49A	16.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1ETR_H_MITH1_1 (EPSILON-THROMBIN)	1elv	COMPLEMENT C1S COMPONENT (Homo sapiens)	7 / 12	HIS A 460 ASP A 611 SER A 617 VAL A 638 TRP A 640 GLY A 641 GLY A 648	SO4  A2001 ( 3.9A) None SO4  A2001 ( 2.7A) None None None None	0.63A	28.21
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	1ETR_H_MITH1_1 (EPSILON-THROMBIN)	1fxy	COAGULATION FACTOR XA-TRYPSIN CHIMERA (Homo sapiens)	7 / 12	HIS A  57 ASP A 189 SER A 195 VAL A 213 TRP A 215 GLY A 216 GLY A 226	0G6  A   1 (-2.7A) 0G6  A   1 (-2.8A) 0G6  A   1 (-1.4A) None None 0G6  A   1 (-3.9A) 0G6  A   1 (-3.3A)	0.67A	38.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1ETR_H_MITH1_1 (EPSILON-THROMBIN)	1gpz	COMPLEMENT C1R COMPONENT (Homo sapiens)	5 / 12	HIS A 485 SER A 637 VAL A 657 GLY A 660 GLY A 668	None	0.83A	24.64
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	1ETR_H_MITH1_1 (EPSILON-THROMBIN)	1gvl	KALLIKREIN 6 (Homo sapiens)	6 / 12	HIS A  57 SER A 195 VAL A 213 TRP A 215 GLY A 216 GLY A 226	None	0.59A	36.43
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	1ETR_H_MITH1_1 (EPSILON-THROMBIN)	1h4w	TRYPSIN IVA (Homo sapiens)	8 / 12	HIS A  57 LEU A  99 ASP A 189 SER A 195 VAL A 213 TRP A 215 GLY A 216 GLY A 226	None None BEN  A 250 (-2.9A) BEN  A 250 (-3.6A) None None BEN  A 250 (-3.9A) BEN  A 250 (-3.3A)	0.45A	37.45
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	1ETR_H_MITH1_1 (EPSILON-THROMBIN)	1o5f	SERINE PROTEASE HEPSIN (Homo sapiens)	7 / 12	HIS H  57 ASP H 189 SER H 195 VAL H 213 TRP H 215 GLY H 216 GLY H 226	CR9  H 256 (-3.9A) CR9  H 256 (-2.4A) CR9  H 256 (-1.5A) CR9  H 256 (-4.3A) None CR9  H 256 ( 3.8A) CR9  H 256 (-3.0A)	0.56A	39.93
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	1ETR_H_MITH1_1 (EPSILON-THROMBIN)	1orf	GRANZYME A (Homo sapiens)	5 / 12	HIS A  57 ASP A 189 SER A 195 GLY A 216 GLY A 226	0G6  A   1 (-2.7A) 0G6  A   1 (-2.9A) 0G6  A   1 (-1.3A) 0G6  A   1 (-3.3A) 0G6  A   1 (-3.5A)	0.65A	30.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1ETR_H_MITH1_1 (EPSILON-THROMBIN)	1q3x	MANNAN-BINDING LECTIN SERINE PROTEASE 2 (Homo sapiens)	7 / 12	HIS A 483 ASP A 627 SER A 633 VAL A 653 TRP A 655 GLY A 656 GLY A 667	None NA  A 800 ( 4.6A) GOL  A 701 (-3.0A) GOL  A 701 (-4.9A) None GOL  A 701 ( 4.1A) GOL  A 701 ( 4.0A)	0.44A	27.17
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	1ETR_H_MITH1_1 (EPSILON-THROMBIN)	1spj	KALLIKREIN 1 (Homo sapiens)	5 / 12	HIS A  57 ASP A 189 SER A 195 TRP A 215 GLY A 216	None	0.65A	31.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1ETR_H_MITH1_1 (EPSILON-THROMBIN)	1zjk	MANNAN-BINDING LECTIN SERINE PROTEASE 2 (Homo sapiens)	6 / 12	HIS A 483 SER A 633 VAL A 653 TRP A 655 GLY A 656 GLY A 667	None	0.68A	23.90
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	1ETR_H_MITH1_1 (EPSILON-THROMBIN)	1zlr	COAGULATION FACTOR XI (Homo sapiens)	6 / 12	HIS A  57 ASP A 189 SER A 195 TRP A 215 GLY A 216 GLY A 226	368  A 901 (-4.0A) 368  A 901 (-2.8A) 368  A 901 (-1.4A) None 368  A 901 (-3.6A) 368  A 901 (-3.5A)	0.43A	37.07
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	1ETR_H_MITH1_1 (EPSILON-THROMBIN)	2ei8	COAGULATION FACTOR X, HEAVY CHAIN (Homo sapiens)	7 / 12	HIS A  57 ASP A 189 SER A 195 VAL A 213 TRP A 215 GLY A 216 GLY A 226	None DT8  A 700 (-3.5A) DT8  A 700 ( 3.9A) DT8  A 700 ( 4.1A) DT8  A 700 (-3.9A) DT8  A 700 (-3.5A) DT8  A 700 (-3.5A)	0.60A	40.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1ETR_H_MITH1_1 (EPSILON-THROMBIN)	2odp	COMPLEMENT C2 (Homo sapiens)	5 / 12	HIS A 487 SER A 659 VAL A 677 TRP A 679 GLY A 680	None	0.59A	19.32
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	1ETR_H_MITH1_1 (EPSILON-THROMBIN)	2oq5	TRANSMEMBRANE PROTEASE, SERINE 11E (Homo sapiens)	7 / 12	HIS A  57 ASP A 189 SER A 195 VAL A 213 TRP A 215 GLY A 216 GLY A 226	None BEN  A 245 (-3.0A) BEN  A 245 (-3.3A) None None BEN  A 245 ( 3.8A) BEN  A 245 (-3.4A)	0.45A	35.14
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	1ETR_H_MITH1_1 (EPSILON-THROMBIN)	2pks	THROMBIN HEAVY CHAIN FRAGMENT (Homo sapiens)	7 / 12	ASP C 229 GLU C 232 SER C 235 VAL C 255 TRP C 257 GLY C 258 GLY C 268	G44  C 101 (-2.6A) None G44  C 101 (-3.5A) None G44  C 101 (-4.1A) G44  C 101 (-3.3A) G44  C 101 (-3.0A)	0.65A	38.34
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	1ETR_H_MITH1_1 (EPSILON-THROMBIN)	2psy	KALLIKREIN-5 (Homo sapiens)	7 / 12	HIS A  57 ASP A 189 SER A 195 VAL A 213 TRP A 215 GLY A 216 GLY A 226	None	0.71A	34.62
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	1ETR_H_MITH1_1 (EPSILON-THROMBIN)	2qy0	COMPLEMENT C1R SUBCOMPONENT (Homo sapiens)	7 / 12	HIS B 485 ASP B 631 SER B 637 VAL B 657 TRP B 659 GLY B 660 GLY B 668	None	0.47A	38.49
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	1ETR_H_MITH1_1 (EPSILON-THROMBIN)	2r0l	HEPATOCYTE GROWTH FACTOR ACTIVATOR (Homo sapiens)	6 / 12	HIS A  57 ASP A 189 SER A 195 TRP A 215 GLY A 216 GLY A 226	None	0.46A	32.59
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	1ETR_H_MITH1_1 (EPSILON-THROMBIN)	2r2w	PLASMINOGEN ACTIVATOR, UROKINASE (Homo sapiens)	6 / 12	HIS U  57 ASP U 189 VAL U 213 TRP U 215 GLY U 216 GLY U 226	4PG  U 300 (-3.9A) 4PG  U 300 (-2.8A) None None 4PG  U 300 (-3.3A) 4PG  U 300 (-3.2A)	0.42A	31.75
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	1ETR_H_MITH1_1 (EPSILON-THROMBIN)	2r2w	PLASMINOGEN ACTIVATOR, UROKINASE (Homo sapiens)	6 / 12	HIS U  57 SER U 195 VAL U 213 TRP U 215 GLY U 216 GLY U 226	4PG  U 300 (-3.9A) 4PG  U 300 (-3.5A) None None 4PG  U 300 (-3.3A) 4PG  U 300 (-3.2A)	0.51A	31.75
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	1ETR_H_MITH1_1 (EPSILON-THROMBIN)	2wpm	COAGULATION FACTOR IXA HEAVY CHAIN (Homo sapiens)	6 / 12	HIS S  57 ASP S 189 SER S 195 TRP S 215 GLY S 216 GLY S 226	None	0.72A	39.15
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	1ETR_H_MITH1_1 (EPSILON-THROMBIN)	2zec	TRYPTASE BETA 2 (Homo sapiens)	7 / 12	HIS A  59 ASP A 203 SER A 209 VAL A 227 TRP A 229 GLY A 230 GLY A 240	None 11N  A   1 (-2.6A) 11N  A   1 (-3.3A) None None 11N  A   1 (-3.9A) 11N  A   1 (-3.6A)	0.55A	36.57
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	1ETR_H_MITH1_1 (EPSILON-THROMBIN)	3f6u	VITAMIN K-DEPENDENT PROTEIN C HEAVY CHAIN (Homo sapiens)	7 / 12	ASP H 189 GLU H 192 SER H 195 VAL H 213 TRP H 215 GLY H 216 GLY H 226	0G6  H   1 (-2.8A) 0G6  H   1 ( 4.0A) 0G6  H   1 (-1.8A) None 0G6  H   1 (-4.1A) 0G6  H   1 (-3.8A) 0G6  H   1 ( 3.9A)	0.66A	41.15
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	1ETR_H_MITH1_1 (EPSILON-THROMBIN)	3f6u	VITAMIN K-DEPENDENT PROTEIN C HEAVY CHAIN (Homo sapiens)	7 / 12	HIS H  57 ASP H 189 SER H 195 VAL H 213 TRP H 215 GLY H 216 GLY H 226	0G6  H   1 (-3.2A) 0G6  H   1 (-2.8A) 0G6  H   1 (-1.8A) None 0G6  H   1 (-4.1A) 0G6  H   1 (-3.8A) 0G6  H   1 ( 3.9A)	0.67A	41.15
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	1ETR_H_MITH1_1 (EPSILON-THROMBIN)	3gov	MASP-1 (Homo sapiens)	7 / 12	HIS B 490 ASP B 640 SER B 646 VAL B 666 TRP B 668 GLY B 669 GLY B 679	None	0.55A	36.13
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	1ETR_H_MITH1_1 (EPSILON-THROMBIN)	3gym	PROSTASIN (Homo sapiens)	7 / 12	HIS A  57 ASP A 189 SER A 195 VAL A 213 TRP A 215 GLY A 216 GLY A 226	None	0.66A	37.32
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	1ETR_H_MITH1_1 (EPSILON-THROMBIN)	3nxp	PRETHROMBIN-1 (Homo sapiens)	5 / 12	HIS A 457 TYR A 460 LEU A 499 VAL A 613 GLY A 626	None	0.57A	87.26
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	1ETR_H_MITH1_1 (EPSILON-THROMBIN)	3r3g	THROMBIN HEAVY CHAIN (Homo sapiens)	10 / 12	HIS B  57 TYR B  60 LEU B  99 ASP B 189 GLU B 192 SER B 195 VAL B 213 TRP B 215 GLY B 216 GLY B 226	None	0.78A	88.03
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	1ETR_H_MITH1_1 (EPSILON-THROMBIN)	3r3g	THROMBIN HEAVY CHAIN (Homo sapiens)	6 / 12	TYR B  60 TRP B  60 LEU B  99 ASP B 189 GLY B 216 GLY B 226	None	0.79A	88.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1ETR_H_MITH1_1 (EPSILON-THROMBIN)	3rip	GAMMA-TUBULIN COMPLEX COMPONENT 4 (Homo sapiens)	5 / 12	LEU A 197 GLU A 304 SER A 188 GLY A 194 GLY A 280	None	0.85A	17.29
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	1ETR_H_MITH1_1 (EPSILON-THROMBIN)	4dgj	ENTEROPEPTIDASE CATALYTIC LIGHT CHAIN (Homo sapiens)	5 / 12	HIS A  41 ASP A 181 SER A 187 GLY A 208 GLY A 218	None	0.72A	35.52
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	1ETR_H_MITH1_1 (EPSILON-THROMBIN)	4fxg	MANNAN-BINDING LECTIN SERINE PROTEASE 2 B CHAIN (Homo sapiens)	6 / 12	HIS H 483 ASP H 627 VAL H 653 TRP H 655 GLY H 656 GLY H 667	None	0.55A	34.47
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	1ETR_H_MITH1_1 (EPSILON-THROMBIN)	4h4f	CHYMOTRYPSIN-C (Homo sapiens)	5 / 12	HIS A  57 LEU A  99 SER A 195 VAL A 213 GLY A 216	None	0.59A	34.98
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	1ETR_H_MITH1_1 (EPSILON-THROMBIN)	4hzh	PROTHROMBIN (Homo sapiens)	6 / 12	HIS A 363 TYR A 367 TRP A 370 LEU A 416 VAL A 545 GLY A 558	None	0.93A	86.87
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	1ETR_H_MITH1_1 (EPSILON-THROMBIN)	4hzh	PROTHROMBIN (Homo sapiens)	6 / 12	HIS A 363 TYR A 367 TRP A 370 VAL A 545 GLY A 548 GLY A 558	None	1.29A	86.87
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	1ETR_H_MITH1_1 (EPSILON-THROMBIN)	4iw4	MANNAN-BINDING LECTIN SERINE PROTEASE 3 (Homo sapiens)	7 / 12	HIS E 478 ASP E 639 SER E 645 VAL E 665 TRP E 667 GLY E 668 GLY E 680	None	0.70A	35.52
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	1ETR_H_MITH1_1 (EPSILON-THROMBIN)	4k8y	KALLIKREIN-4 (Homo sapiens)	6 / 12	HIS A  57 ASP A 189 SER A 195 VAL A 213 GLY A 216 GLY A 226	None	0.57A	32.32
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	1ETR_H_MITH1_1 (EPSILON-THROMBIN)	4k8y	KALLIKREIN-4 (Homo sapiens)	6 / 12	LEU A  99 ASP A 189 SER A 195 VAL A 213 GLY A 216 GLY A 226	None	0.86A	32.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1ETR_H_MITH1_1 (EPSILON-THROMBIN)	4kkd	MANNAN-BINDING LECTIN SERINE PROTEASE 1 (Homo sapiens)	5 / 12	HIS A 497 VAL A 684 TRP A 686 GLY A 687 GLY A 699	None	0.54A	24.53
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	1ETR_H_MITH1_1 (EPSILON-THROMBIN)	4nff	KALLIKREIN-2 (Homo sapiens)	5 / 12	HIS A  57 ASP A 189 SER A 195 TRP A 215 GLY A 216	0G6  A 301 (-2.7A) 0G6  A 301 (-3.0A) 0G6  A 301 (-1.4A) 0G6  A 301 (-3.7A) 0G6  A 301 (-3.4A)	0.82A	34.07
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	1ETR_H_MITH1_1 (EPSILON-THROMBIN)	4r0i	SUPPRESSOR OF TUMORIGENICITY 14 PROTEIN (Homo sapiens)	7 / 12	HIS A  57 ASP A 189 SER A 195 VAL A 213 TRP A 215 GLY A 216 GLY A 226	3KM  A 900 ( 4.4A) 3KM  A 900 (-2.9A) 3KM  A 900 (-3.6A) None None 3KM  A 900 (-3.4A) 3KM  A 900 (-3.2A)	0.50A	35.88
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	1ETR_H_MITH1_1 (EPSILON-THROMBIN)	4wwy	TRYPSIN-1 (Homo sapiens)	8 / 12	HIS A  57 LEU A  99 ASP A 189 SER A 195 VAL A 213 TRP A 215 GLY A 216 GLY A 226	None	0.70A	36.68
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	1ETR_H_MITH1_1 (EPSILON-THROMBIN)	4ylq	COAGULATION FACTOR VII (Homo sapiens)	7 / 12	HIS H  57 ASP H 189 SER H 195 VAL H 213 TRP H 215 GLY H 216 GLY H 226	0Z7  H 501 (-2.6A) 0Z7  H 501 (-2.3A) 0Z7  H 501 (-1.4A) 0Z7  H 501 ( 4.7A) TMA  H 508 ( 3.9A) 0Z7  H 501 (-3.4A) 0Z7  H 501 (-3.0A)	0.63A	36.64
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	1ETR_H_MITH1_1 (EPSILON-THROMBIN)	5brr	TISSUE-TYPE PLASMINOGEN ACTIVATOR (Homo sapiens)	5 / 12	HIS E  57 ASP E 189 TRP E 215 GLY E 216 GLY E 226	None	0.50A	32.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1ETR_H_MITH1_1 (EPSILON-THROMBIN)	5eod	COAGULATION FACTOR XI (Homo sapiens)	5 / 12	HIS A 413 SER A 557 TRP A 577 GLY A 578 GLY A 588	None	0.80A	17.17
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	1ETR_H_MITH1_1 (EPSILON-THROMBIN)	5f8z	PLASMA KALLIKREIN LIGHT CHAIN (Homo sapiens)	6 / 12	HIS A  57 ASP A 189 SER A 195 TRP A 215 GLY A 216 GLY A 226	None	0.47A	39.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1ETR_H_MITH1_1 (EPSILON-THROMBIN)	5ms3	KALLIKREIN-8 (Homo sapiens)	6 / 12	HIS A  57 ASP A 189 SER A 195 TRP A 215 GLY A 216 GLY A 226	None	0.58A	15.27
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	1ETR_H_MITH1_1 (EPSILON-THROMBIN)	5o32	COMPLEMENT FACTOR I (Homo sapiens)	5 / 12	ASP I 519 VAL I 544 TRP I 546 GLY I 547 GLY I 557	None	0.86A	34.32
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	1ETR_H_MITH1_1 (EPSILON-THROMBIN)	5o32	COMPLEMENT FACTOR I (Homo sapiens)	5 / 12	HIS I 380 VAL I 544 TRP I 546 GLY I 547 GLY I 557	None	0.61A	34.32
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	1ETR_H_MITH1_1 (EPSILON-THROMBIN)	5to3	PROTHROMBIN,THROMBOM ODULIN (Homo sapiens)	8 / 12	HIS B  58 TYR B  62 LEU B 111 ASP B 214 SER B 220 VAL B 240 GLY B 243 GLY B 253	0G6  B 501 (-2.5A) 0G6  B 501 (-3.7A) 0G6  B 501 ( 3.8A) 0G6  B 501 (-2.9A) 0G6  B 501 (-1.3A) None 0G6  B 501 (-3.7A) 0G6  B 501 (-3.6A)	0.60A	79.51
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	1ETR_H_MITH1_1 (EPSILON-THROMBIN)	5to3	PROTHROMBIN,THROMBOM ODULIN (Homo sapiens)	6 / 12	TYR B  62 TRP B  65 LEU B 111 ASP B 214 GLY B 243 GLY B 253	0G6  B 501 (-3.7A) 0G6  B 501 (-4.8A) 0G6  B 501 ( 3.8A) 0G6  B 501 (-2.9A) 0G6  B 501 (-3.7A) 0G6  B 501 (-3.6A)	0.73A	79.51
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	1ETR_H_MITH1_1 (EPSILON-THROMBIN)	5ubm	COMPLEMENT C1S SUBCOMPONENT (Homo sapiens)	7 / 12	HIS A 475 ASP A 626 SER A 632 VAL A 653 TRP A 655 GLY A 656 GLY A 663	None	0.71A	34.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1ETR_H_MITH1_1 (EPSILON-THROMBIN)	6b74	COAGULATION FACTOR XII (Homo sapiens)	6 / 12	HIS B  57 ASP B 189 SER B 195 TRP B 215 GLY B 216 GLY B 226	SO4  B 304 (-3.8A) BEN  B 301 (-2.7A) SO4  B 304 ( 2.5A) None BEN  B 301 (-3.3A) BEN  B 301 (-3.1A)	0.58A	15.66