POTENTIAL TARGETS FROM HUMAN (RESULTS FROM SUB-STRUCTURAL SIMILARITY SEARCHES)1) User may click on the DrReposER ID (the second column) to get information on the binding sites and drug molecule.
2) Click View (the second last column) to view matched residues and superposition in the NGL viewer (upper right part).
3) User may also click on the Dock (the last column) to get script for molecular docking in UCSF Chimera through AutoDock Vina.

	DrReposER ID / Desc.	Hit PDBID	Hit Macromolecule	Res. Matches	Interface	HETATM	RMSD	Seq. Identity (%)	View	Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1S19_A_MC9A500_0 (VITAMIN D3 RECEPTOR)	2hrb	CARBONYL REDUCTASE [NADPH] 3 (Homo sapiens)	5 / 12	LEU A 256 VAL A 252 VAL A  33 LEU A  50 LEU A  55	None	1.16A	23.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1S19_A_MC9A500_0 (VITAMIN D3 RECEPTOR)	3bhi	CARBONYL REDUCTASE [NADPH] 1 (Homo sapiens)	5 / 12	LEU A 255 VAL A 251 VAL A  32 LEU A  49 LEU A  54	None	1.14A	20.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1S19_A_MC9A500_0 (VITAMIN D3 RECEPTOR)	3cuq	VACUOLAR-SORTING PROTEIN SNF8 VACUOLAR PROTEIN-SORTING-ASSO CIATED PROTEIN 36 (Homo sapiens; Homo sapiens)	5 / 12	LEU A 154 LEU B 272 VAL B 273 ILE B 252 LEU B 294	None	1.04A	23.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1S19_A_MC9A500_0 (VITAMIN D3 RECEPTOR)	3cuq	VACUOLAR-SORTING PROTEIN SNF8 VACUOLAR PROTEIN-SORTING-ASSO CIATED PROTEIN 36 (Homo sapiens; Homo sapiens)	5 / 12	LEU A 154 VAL B 273 ILE B 252 LEU B 294 LEU B 301	None	0.98A	23.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1S19_A_MC9A500_0 (VITAMIN D3 RECEPTOR)	3szb	ALDEHYDE DEHYDROGENASE (Homo sapiens)	5 / 12	LEU A  29 LEU A  67 VAL A  66 LEU A 136 LEU A 149	None	1.14A	18.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1S19_A_MC9A500_0 (VITAMIN D3 RECEPTOR)	3t04	MONOBODY 7C12 (Homo sapiens)	5 / 12	VAL D  81 ILE D  97 SER D  95 TYR D  84 VAL D  38	None	1.07A	18.11
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	1S19_A_MC9A500_0 (VITAMIN D3 RECEPTOR)	3wgp	VITAMIN D3 RECEPTOR (Homo sapiens)	12 / 12	LEU A 227 LEU A 233 VAL A 234 ILE A 271 SER A 275 SER A 278 TRP A 286 CYH A 288 TYR A 295 VAL A 300 LEU A 309 LEU A 313	None ED9  A 501 ( 4.3A) None ED9  A 501 (-4.5A) ED9  A 501 (-3.9A) ED9  A 501 (-2.7A) ED9  A 501 (-3.5A) ED9  A 501 (-3.4A) None ED9  A 501 (-4.5A) ED9  A 501 (-4.9A) None	0.16A	100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1S19_A_MC9A500_0 (VITAMIN D3 RECEPTOR)	4npk	EXTENDED SYNAPTOTAGMIN-2 (Homo sapiens)	5 / 12	ILE A 418 SER A 427 TRP A 438 LEU A 491 LEU A 458	None	1.02A	23.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1S19_A_MC9A500_0 (VITAMIN D3 RECEPTOR)	4p42	EXTENDED SYNAPTOTAGMIN-2 (Homo sapiens)	5 / 12	ILE A 390 SER A 399 TRP A 410 LEU A 463 LEU A 430	None	1.02A	20.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1S19_A_MC9A500_0 (VITAMIN D3 RECEPTOR)	4rh7	GREEN FLUORESCENT PROTEIN/CYTOPLASMIC DYNEIN 2 HEAVY CHAIN 1 (Homo sapiens; synthetic construct)	5 / 12	LEU A1904 SER A2049 TRP A2051 LEU A1939 LEU A1996	None	1.11A	6.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1S19_A_MC9A500_0 (VITAMIN D3 RECEPTOR)	4uuc	ANKYRIN REPEAT AND SOCS BOX PROTEIN 11 (Homo sapiens)	5 / 12	LEU A 150 VAL A 149 SER A 143 SER A 141 LEU A  78	None	1.17A	23.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1S19_A_MC9A500_0 (VITAMIN D3 RECEPTOR)	5hdt	SISTER CHROMATID COHESION PROTEIN PDS5 HOMOLOG B (Homo sapiens)	5 / 12	LEU A 355 VAL A 385 ILE A 382 TRP A 435 LEU A 412	None	1.10A	12.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1S19_A_MC9A500_0 (VITAMIN D3 RECEPTOR)	5i2x	ADRENOCORTICAL DYSPLASIA PROTEIN HOMOLOG (Homo sapiens)	5 / 12	LEU A 144 VAL A 205 TYR A 202 VAL A 153 LEU A 102	None	1.15A	22.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1S19_A_MC9A500_0 (VITAMIN D3 RECEPTOR)	5lb3	ATP-DEPENDENT DNA HELICASE Q5 (Homo sapiens)	5 / 12	VAL B  76 ILE B 128 TYR B  62 LEU B 183 LEU B 151	None	1.12A	19.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1S19_A_MC9A500_0 (VITAMIN D3 RECEPTOR)	5mvd	DIHYDROOROTATE DEHYDROGENASE (QUINONE), MITOCHONDRIAL (Homo sapiens)	6 / 12	LEU A 182 LEU A 253 VAL A 252 ILE A 277 VAL A 213 LEU A 230	None	1.37A	22.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1S19_A_MC9A500_1 (VITAMIN D3 RECEPTOR)	1zkl	HIGH-AFFINITY CAMP-SPECIFIC 3',5'-CYCLIC PHOSPHODIESTERASE 7A (Homo sapiens)	4 / 5	SER A 236 ARG A 350 HIS A 225 HIS A 181	None	1.32A	21.51
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	1S19_A_MC9A500_1 (VITAMIN D3 RECEPTOR)	3wgp	VITAMIN D3 RECEPTOR (Homo sapiens)	5 / 5	TYR A 143 SER A 237 ARG A 274 HIS A 305 HIS A 397	ED9  A 501 (-3.7A) ED9  A 501 (-2.7A) ED9  A 501 (-2.9A) ED9  A 501 (-3.9A) ED9  A 501 (-3.9A)	0.13A	100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1S19_A_MC9A500_1 (VITAMIN D3 RECEPTOR)	5v4r	LA-RELATED PROTEIN 1 (Homo sapiens)	4 / 5	TYR A 883 SER A 843 ARG A 847 HIS A 797	MGT  A1001 (-3.9A) None None None	1.39A	20.62