POTENTIAL TARGETS FROM HUMAN (RESULTS FROM SUB-STRUCTURAL SIMILARITY SEARCHES)
1) User may click on the DrReposER ID (the second column) to get information on the binding sites and drug molecule.
2) Click View (the second last column) to view matched residues and superposition in the NGL viewer (upper right part).
3) User may also click on the Dock (the last column) to get script for molecular docking in UCSF Chimera through AutoDock Vina.

DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1J36_A_LPRA801_1
(ANGIOTENSIN
CONVERTING ENZYME)		2o36 THIMET
OLIGOPEPTIDASE
(Homo
sapiens)		5 / 12THR A 470
HIS A 473
GLU A 474
HIS A 477
GLU A 502
None
ZN  A 690 (-3.4A)
ZN  A 690 ( 4.1A)
ZN  A 690 (-3.3A)
ZN  A 690 (-2.3A)
0.44A22.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1J36_A_LPRA801_1
(ANGIOTENSIN
CONVERTING ENZYME)		2o36 THIMET
OLIGOPEPTIDASE
(Homo
sapiens)		5 / 12THR A 470
HIS A 473
GLU A 474
HIS A 477
TYR A 612
None
ZN  A 690 (-3.4A)
ZN  A 690 ( 4.1A)
ZN  A 690 (-3.3A)
None
0.99A22.88
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1J36_A_LPRA801_1
(ANGIOTENSIN
CONVERTING ENZYME)		2xy9 ANGIOTENSIN-CONVERTI
NG ENZYME
(Homo
sapiens)		11 / 12GLN A 281
HIS A 353
HIS A 383
GLU A 384
HIS A 387
GLU A 411
LYS A 511
HIS A 513
VAL A 518
TYR A 520
TYR A 523
3ES  A1635 (-3.3A)
3ES  A1635 (-3.8A)
ZN  A1628 ( 3.2A)
3ES  A1635 (-2.8A)
ZN  A1628 ( 3.2A)
ZN  A1628 ( 2.4A)
3ES  A1635 (-2.6A)
3ES  A1635 (-3.9A)
3ES  A1636 (-4.1A)
3ES  A1635 (-4.7A)
3ES  A1635 (-3.4A)
0.25A43.71
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1J36_A_LPRA801_1
(ANGIOTENSIN
CONVERTING ENZYME)		2xy9 ANGIOTENSIN-CONVERTI
NG ENZYME
(Homo
sapiens)		9 / 12HIS A 353
GLU A 384
HIS A 383
GLU A 411
LYS A 511
HIS A 513
VAL A 518
TYR A 520
TYR A 523
3ES  A1635 (-3.8A)
3ES  A1635 (-2.8A)
ZN  A1628 ( 3.2A)
ZN  A1628 ( 2.4A)
3ES  A1635 (-2.6A)
3ES  A1635 (-3.9A)
3ES  A1636 (-4.1A)
3ES  A1635 (-4.7A)
3ES  A1635 (-3.4A)
1.41A43.71
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1J36_A_LPRA801_1
(ANGIOTENSIN
CONVERTING ENZYME)		2xyd ANGIOTENSIN-CONVERTI
NG ENZYME
(Homo
sapiens)		11 / 12GLN A 259
HIS A 331
THR A 358
HIS A 361
GLU A 362
HIS A 365
GLU A 389
LYS A 489
HIS A 491
TYR A 498
TYR A 501
3ES  A1611 (-3.1A)
3ES  A1611 (-3.8A)
3ES  A1611 (-3.6A)
3ES  A1611 ( 3.2A)
3ES  A1611 (-2.5A)
ZN  A1620 ( 3.2A)
ZN  A1620 ( 2.4A)
3ES  A1611 (-2.6A)
3ES  A1611 (-3.9A)
3ES  A1611 (-4.7A)
3ES  A1611 (-3.5A)
0.30A40.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1J36_A_LPRA801_1
(ANGIOTENSIN
CONVERTING ENZYME)		2yd0 ENDOPLASMIC
RETICULUM
AMINOPEPTIDASE 1
(Homo
sapiens)		6 / 12THR A 350
HIS A 353
GLU A 354
HIS A 357
GLU A 376
TYR A 438
BES  A1950 ( 4.3A)
ZN  A1946 ( 3.3A)
BES  A1950 (-3.3A)
BES  A1950 ( 3.3A)
ZN  A1946 ( 2.1A)
BES  A1950 (-4.3A)
0.77A22.77
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1J36_A_LPRA801_1
(ANGIOTENSIN
CONVERTING ENZYME)		3kbh ANGIOTENSIN-CONVERTI
NG ENZYME 2
(Homo
sapiens)		5 / 12THR A 371
HIS A 374
GLU A 375
HIS A 378
GLU A 402
None
0.53A36.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1J36_A_LPRA801_1
(ANGIOTENSIN
CONVERTING ENZYME)		3odo RHO GUANINE
NUCLEOTIDE EXCHANGE
FACTOR 1
(Homo
sapiens)		5 / 12THR A 427
HIS A 431
GLU A 428
HIS A 471
GLU A 561
None
0.87A21.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1J36_A_LPRA801_1
(ANGIOTENSIN
CONVERTING ENZYME)		3u9w LEUKOTRIENE A-4
HYDROLASE
(Homo
sapiens)		5 / 12HIS A1295
GLU A1296
HIS A1299
GLU A1318
TYR A1383
 ZN  A2001 ( 3.2A)
28P  A7001 (-2.6A)
ZN  A2001 ( 3.2A)
ZN  A2001 ( 2.2A)
28P  A7001 (-4.6A)
0.70A20.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1J36_A_LPRA801_1
(ANGIOTENSIN
CONVERTING ENZYME)		3zus BOTULINUM NEUROTOXIN
TYPE A,
SYNAPTOSOMAL-ASSOCIA
TED PROTEIN 23
(Clostridium
botulinum;
Homo
sapiens)		6 / 12THR A 220
HIS A 223
GLU A 224
HIS A 227
GLU A 262
TYR A 366
None
ZN  A1916 (-3.3A)
ZN  A1916 ( 4.3A)
ZN  A1916 (-3.3A)
ZN  A1916 (-2.0A)
None
0.82A20.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1J36_A_LPRA801_1
(ANGIOTENSIN
CONVERTING ENZYME)		4fys AMINOPEPTIDASE N
(Homo
sapiens)		5 / 12HIS A 388
GLU A 389
HIS A 392
GLU A 411
TYR A 477
None
0.81A20.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1J36_A_LPRA801_1
(ANGIOTENSIN
CONVERTING ENZYME)		4gwn MEPRIN A SUBUNIT
BETA
(Homo
sapiens)		5 / 12THR A 149
HIS A 152
GLU A 153
HIS A 156
TYR A 211
None
CD  A 701 (-3.7A)
CD  A 701 (-3.5A)
CD  A 701 (-3.7A)
None
0.41A21.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1J36_A_LPRA801_1
(ANGIOTENSIN
CONVERTING ENZYME)		4kxb GLUTAMYL
AMINOPEPTIDASE
(Homo
sapiens)		5 / 12HIS A 393
GLU A 394
HIS A 397
GLU A 416
TYR A 479
 ZN  A1001 ( 3.3A)
BES  A1017 (-3.1A)
ZN  A1001 ( 3.2A)
ZN  A1001 ( 2.4A)
BES  A1017 (-4.2A)
0.82A21.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1J36_A_LPRA801_1
(ANGIOTENSIN
CONVERTING ENZYME)		4pj6 LEUCYL-CYSTINYL
AMINOPEPTIDASE
(Homo
sapiens)		5 / 12HIS A 464
GLU A 465
HIS A 468
GLU A 487
TYR A 549
 ZN  A1101 ( 3.2A)
LYS  A1102 (-3.4A)
ZN  A1101 (-3.2A)
ZN  A1101 ( 1.9A)
None
0.84A23.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1J36_A_LPRA801_1
(ANGIOTENSIN
CONVERTING ENZYME)		4wgk NEUTRAL CERAMIDASE
(Homo
sapiens)		5 / 12GLN A 471
HIS A 303
HIS A 194
GLU A 540
TYR A 579
None
ZN  A 801 ( 3.2A)
ZN  A 801 ( 3.3A)
ZN  A 801 ( 2.0A)
ZN  A 801 ( 4.3A)
1.18A21.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1J36_A_LPRA801_1
(ANGIOTENSIN
CONVERTING ENZYME)		5j6s ENDOPLASMIC
RETICULUM
AMINOPEPTIDASE 2
(Homo
sapiens)		5 / 12HIS A 370
GLU A 371
HIS A 374
GLU A 393
TYR A 455
 ZN  A1001 ( 3.2A)
6GA  A1015 (-3.0A)
ZN  A1001 ( 3.2A)
ZN  A1001 ( 1.7A)
6GA  A1015 (-4.0A)
0.75A21.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1J36_B_LPRB802_1
(ANGIOTENSIN
CONVERTING ENZYME)		2o36 THIMET
OLIGOPEPTIDASE
(Homo
sapiens)		5 / 12THR A 470
HIS A 473
GLU A 474
HIS A 477
GLU A 502
None
ZN  A 690 (-3.4A)
ZN  A 690 ( 4.1A)
ZN  A 690 (-3.3A)
ZN  A 690 (-2.3A)
0.45A22.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1J36_B_LPRB802_1
(ANGIOTENSIN
CONVERTING ENZYME)		2o36 THIMET
OLIGOPEPTIDASE
(Homo
sapiens)		5 / 12THR A 470
HIS A 473
GLU A 474
HIS A 477
TYR A 612
None
ZN  A 690 (-3.4A)
ZN  A 690 ( 4.1A)
ZN  A 690 (-3.3A)
None
0.99A22.88
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1J36_B_LPRB802_1
(ANGIOTENSIN
CONVERTING ENZYME)		2xy9 ANGIOTENSIN-CONVERTI
NG ENZYME
(Homo
sapiens)		11 / 12GLN A 281
HIS A 353
HIS A 383
GLU A 384
HIS A 387
GLU A 411
LYS A 511
HIS A 513
VAL A 518
TYR A 520
TYR A 523
3ES  A1635 (-3.3A)
3ES  A1635 (-3.8A)
ZN  A1628 ( 3.2A)
3ES  A1635 (-2.8A)
ZN  A1628 ( 3.2A)
ZN  A1628 ( 2.4A)
3ES  A1635 (-2.6A)
3ES  A1635 (-3.9A)
3ES  A1636 (-4.1A)
3ES  A1635 (-4.7A)
3ES  A1635 (-3.4A)
0.26A43.71
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1J36_B_LPRB802_1
(ANGIOTENSIN
CONVERTING ENZYME)		2xy9 ANGIOTENSIN-CONVERTI
NG ENZYME
(Homo
sapiens)		9 / 12HIS A 353
GLU A 384
HIS A 383
GLU A 411
LYS A 511
HIS A 513
VAL A 518
TYR A 520
TYR A 523
3ES  A1635 (-3.8A)
3ES  A1635 (-2.8A)
ZN  A1628 ( 3.2A)
ZN  A1628 ( 2.4A)
3ES  A1635 (-2.6A)
3ES  A1635 (-3.9A)
3ES  A1636 (-4.1A)
3ES  A1635 (-4.7A)
3ES  A1635 (-3.4A)
1.42A43.71
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1J36_B_LPRB802_1
(ANGIOTENSIN
CONVERTING ENZYME)		2xyd ANGIOTENSIN-CONVERTI
NG ENZYME
(Homo
sapiens)		11 / 12GLN A 259
HIS A 331
THR A 358
HIS A 361
GLU A 362
HIS A 365
GLU A 389
LYS A 489
HIS A 491
TYR A 498
TYR A 501
3ES  A1611 (-3.1A)
3ES  A1611 (-3.8A)
3ES  A1611 (-3.6A)
3ES  A1611 ( 3.2A)
3ES  A1611 (-2.5A)
ZN  A1620 ( 3.2A)
ZN  A1620 ( 2.4A)
3ES  A1611 (-2.6A)
3ES  A1611 (-3.9A)
3ES  A1611 (-4.7A)
3ES  A1611 (-3.5A)
0.30A40.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1J36_B_LPRB802_1
(ANGIOTENSIN
CONVERTING ENZYME)		2yd0 ENDOPLASMIC
RETICULUM
AMINOPEPTIDASE 1
(Homo
sapiens)		6 / 12THR A 350
HIS A 353
GLU A 354
HIS A 357
GLU A 376
TYR A 438
BES  A1950 ( 4.3A)
ZN  A1946 ( 3.3A)
BES  A1950 (-3.3A)
BES  A1950 ( 3.3A)
ZN  A1946 ( 2.1A)
BES  A1950 (-4.3A)
0.77A22.77
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1J36_B_LPRB802_1
(ANGIOTENSIN
CONVERTING ENZYME)		3kbh ANGIOTENSIN-CONVERTI
NG ENZYME 2
(Homo
sapiens)		5 / 12THR A 371
HIS A 374
GLU A 375
HIS A 378
GLU A 402
None
0.53A36.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1J36_B_LPRB802_1
(ANGIOTENSIN
CONVERTING ENZYME)		3odo RHO GUANINE
NUCLEOTIDE EXCHANGE
FACTOR 1
(Homo
sapiens)		5 / 12THR A 427
HIS A 431
GLU A 428
HIS A 471
GLU A 561
None
0.86A21.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1J36_B_LPRB802_1
(ANGIOTENSIN
CONVERTING ENZYME)		3u9w LEUKOTRIENE A-4
HYDROLASE
(Homo
sapiens)		5 / 12HIS A1295
GLU A1296
HIS A1299
GLU A1318
TYR A1383
 ZN  A2001 ( 3.2A)
28P  A7001 (-2.6A)
ZN  A2001 ( 3.2A)
ZN  A2001 ( 2.2A)
28P  A7001 (-4.6A)
0.70A20.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1J36_B_LPRB802_1
(ANGIOTENSIN
CONVERTING ENZYME)		3zus BOTULINUM NEUROTOXIN
TYPE A,
SYNAPTOSOMAL-ASSOCIA
TED PROTEIN 23
(Clostridium
botulinum;
Homo
sapiens)		6 / 12THR A 220
HIS A 223
GLU A 224
HIS A 227
GLU A 262
TYR A 366
None
ZN  A1916 (-3.3A)
ZN  A1916 ( 4.3A)
ZN  A1916 (-3.3A)
ZN  A1916 (-2.0A)
None
0.82A20.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1J36_B_LPRB802_1
(ANGIOTENSIN
CONVERTING ENZYME)		4fys AMINOPEPTIDASE N
(Homo
sapiens)		5 / 12HIS A 388
GLU A 389
HIS A 392
GLU A 411
TYR A 477
None
0.81A20.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1J36_B_LPRB802_1
(ANGIOTENSIN
CONVERTING ENZYME)		4gwn MEPRIN A SUBUNIT
BETA
(Homo
sapiens)		5 / 12THR A 149
HIS A 152
GLU A 153
HIS A 156
TYR A 211
None
CD  A 701 (-3.7A)
CD  A 701 (-3.5A)
CD  A 701 (-3.7A)
None
0.41A21.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1J36_B_LPRB802_1
(ANGIOTENSIN
CONVERTING ENZYME)		4kxb GLUTAMYL
AMINOPEPTIDASE
(Homo
sapiens)		5 / 12HIS A 393
GLU A 394
HIS A 397
GLU A 416
TYR A 479
 ZN  A1001 ( 3.3A)
BES  A1017 (-3.1A)
ZN  A1001 ( 3.2A)
ZN  A1001 ( 2.4A)
BES  A1017 (-4.2A)
0.83A21.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1J36_B_LPRB802_1
(ANGIOTENSIN
CONVERTING ENZYME)		4pj6 LEUCYL-CYSTINYL
AMINOPEPTIDASE
(Homo
sapiens)		5 / 12HIS A 464
GLU A 465
HIS A 468
GLU A 487
TYR A 549
 ZN  A1101 ( 3.2A)
LYS  A1102 (-3.4A)
ZN  A1101 (-3.2A)
ZN  A1101 ( 1.9A)
None
0.85A23.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1J36_B_LPRB802_1
(ANGIOTENSIN
CONVERTING ENZYME)		4wgk NEUTRAL CERAMIDASE
(Homo
sapiens)		5 / 12GLN A 471
HIS A 303
HIS A 194
GLU A 540
TYR A 579
None
ZN  A 801 ( 3.2A)
ZN  A 801 ( 3.3A)
ZN  A 801 ( 2.0A)
ZN  A 801 ( 4.3A)
1.17A21.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1J36_B_LPRB802_1
(ANGIOTENSIN
CONVERTING ENZYME)		5j6s ENDOPLASMIC
RETICULUM
AMINOPEPTIDASE 2
(Homo
sapiens)		5 / 12HIS A 370
GLU A 371
HIS A 374
GLU A 393
TYR A 455
 ZN  A1001 ( 3.2A)
6GA  A1015 (-3.0A)
ZN  A1001 ( 3.2A)
ZN  A1001 ( 1.7A)
6GA  A1015 (-4.0A)
0.75A21.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1O86_A_LPRA702_1
(ANGIOTENSIN
CONVERTING ENZYME)		2o36 THIMET
OLIGOPEPTIDASE
(Homo
sapiens)		5 / 12GLU A 502
HIS A 473
GLU A 474
PHE A 428
TYR A 422
 ZN  A 690 (-2.3A)
ZN  A 690 (-3.4A)
ZN  A 690 ( 4.1A)
None
None
1.31A22.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1O86_A_LPRA702_1
(ANGIOTENSIN
CONVERTING ENZYME)		2vr2 DIHYDROPYRIMIDINASE
(Homo
sapiens)		5 / 12GLU A 271
HIS A 248
PHE A  74
HIS A 192
TYR A 164
None
ZN  A1495 (-3.4A)
None
ZN  A1495 (-3.7A)
None
1.42A22.33
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1O86_A_LPRA702_1
(ANGIOTENSIN
CONVERTING ENZYME)		2xy9 ANGIOTENSIN-CONVERTI
NG ENZYME
(Homo
sapiens)		12 / 12GLU A 162
GLN A 281
HIS A 353
HIS A 383
GLU A 384
HIS A 387
GLU A 411
PHE A 457
LYS A 511
HIS A 513
TYR A 520
TYR A 523
None
3ES  A1635 (-3.3A)
3ES  A1635 (-3.8A)
ZN  A1628 ( 3.2A)
3ES  A1635 (-2.8A)
ZN  A1628 ( 3.2A)
ZN  A1628 ( 2.4A)
3ES  A1635 (-4.1A)
3ES  A1635 (-2.6A)
3ES  A1635 (-3.9A)
3ES  A1635 (-4.7A)
3ES  A1635 (-3.4A)
0.37A99.83
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1O86_A_LPRA702_1
(ANGIOTENSIN
CONVERTING ENZYME)		2xy9 ANGIOTENSIN-CONVERTI
NG ENZYME
(Homo
sapiens)		5 / 12GLU A 162
HIS A 353
PHE A 460
HIS A 513
TYR A 520
None
3ES  A1635 (-3.8A)
None
3ES  A1635 (-3.9A)
3ES  A1635 (-4.7A)
1.39A99.83
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1O86_A_LPRA702_1
(ANGIOTENSIN
CONVERTING ENZYME)		2xy9 ANGIOTENSIN-CONVERTI
NG ENZYME
(Homo
sapiens)		5 / 12HIS A 383
GLU A 384
HIS A 387
GLU A 411
PHE A 527
 ZN  A1628 ( 3.2A)
3ES  A1635 (-2.8A)
ZN  A1628 ( 3.2A)
ZN  A1628 ( 2.4A)
3ES  A1635 (-4.6A)
1.05A99.83
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1O86_A_LPRA702_1
(ANGIOTENSIN
CONVERTING ENZYME)		2xyd ANGIOTENSIN-CONVERTI
NG ENZYME
(Homo
sapiens)		11 / 12GLN A 259
HIS A 331
HIS A 361
GLU A 362
HIS A 365
GLU A 389
PHE A 435
LYS A 489
HIS A 491
TYR A 498
TYR A 501
3ES  A1611 (-3.1A)
3ES  A1611 (-3.8A)
3ES  A1611 ( 3.2A)
3ES  A1611 (-2.5A)
ZN  A1620 ( 3.2A)
ZN  A1620 ( 2.4A)
3ES  A1611 ( 4.2A)
3ES  A1611 (-2.6A)
3ES  A1611 (-3.9A)
3ES  A1611 (-4.7A)
3ES  A1611 (-3.5A)
0.26A53.76
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1O86_A_LPRA702_1
(ANGIOTENSIN
CONVERTING ENZYME)		2xyd ANGIOTENSIN-CONVERTI
NG ENZYME
(Homo
sapiens)		5 / 12HIS A 361
GLU A 362
HIS A 365
GLU A 389
PHE A 505
3ES  A1611 ( 3.2A)
3ES  A1611 (-2.5A)
ZN  A1620 ( 3.2A)
ZN  A1620 ( 2.4A)
3ES  A1611 (-4.7A)
1.00A53.76
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1O86_A_LPRA702_1
(ANGIOTENSIN
CONVERTING ENZYME)		2xyd ANGIOTENSIN-CONVERTI
NG ENZYME
(Homo
sapiens)		5 / 12HIS A 491
GLU A 389
HIS A 361
GLU A 362
HIS A 331
3ES  A1611 (-3.9A)
ZN  A1620 ( 2.4A)
3ES  A1611 ( 3.2A)
3ES  A1611 (-2.5A)
3ES  A1611 (-3.8A)
1.31A53.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1O86_A_LPRA702_1
(ANGIOTENSIN
CONVERTING ENZYME)		2yd0 ENDOPLASMIC
RETICULUM
AMINOPEPTIDASE 1
(Homo
sapiens)		5 / 12HIS A 353
GLU A 354
HIS A 357
GLU A 376
TYR A 438
 ZN  A1946 ( 3.3A)
BES  A1950 (-3.3A)
BES  A1950 ( 3.3A)
ZN  A1946 ( 2.1A)
BES  A1950 (-4.3A)
0.75A21.15
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1O86_A_LPRA702_1
(ANGIOTENSIN
CONVERTING ENZYME)		3kbh ANGIOTENSIN-CONVERTI
NG ENZYME 2
(Homo
sapiens)		5 / 12HIS A 374
GLU A 375
HIS A 378
GLU A 402
PHE A 274
None
0.74A42.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1O86_A_LPRA702_1
(ANGIOTENSIN
CONVERTING ENZYME)		3u9w LEUKOTRIENE A-4
HYDROLASE
(Homo
sapiens)		5 / 12HIS A1295
GLU A1296
HIS A1299
GLU A1318
TYR A1383
 ZN  A2001 ( 3.2A)
28P  A7001 (-2.6A)
ZN  A2001 ( 3.2A)
ZN  A2001 ( 2.2A)
28P  A7001 (-4.6A)
0.64A24.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1O86_A_LPRA702_1
(ANGIOTENSIN
CONVERTING ENZYME)		3zus BOTULINUM NEUROTOXIN
TYPE A,
SYNAPTOSOMAL-ASSOCIA
TED PROTEIN 23
(Clostridium
botulinum;
Homo
sapiens)		5 / 12HIS A 223
GLU A 224
HIS A 227
GLU A 262
TYR A 366
 ZN  A1916 (-3.3A)
ZN  A1916 ( 4.3A)
ZN  A1916 (-3.3A)
ZN  A1916 (-2.0A)
None
0.91A20.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1O86_A_LPRA702_1
(ANGIOTENSIN
CONVERTING ENZYME)		4fys AMINOPEPTIDASE N
(Homo
sapiens)		5 / 12HIS A 388
GLU A 389
HIS A 392
GLU A 411
TYR A 477
None
0.79A20.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1O86_A_LPRA702_1
(ANGIOTENSIN
CONVERTING ENZYME)		4fzv MTERF
DOMAIN-CONTAINING
PROTEIN 2
(Homo
sapiens)		5 / 12GLU B 323
HIS B 265
GLU B 269
TYR B 232
TYR B 236
None
1.43A15.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1O86_A_LPRA702_1
(ANGIOTENSIN
CONVERTING ENZYME)		4kxb GLUTAMYL
AMINOPEPTIDASE
(Homo
sapiens)		5 / 12HIS A 393
GLU A 394
HIS A 397
GLU A 416
TYR A 479
 ZN  A1001 ( 3.3A)
BES  A1017 (-3.1A)
ZN  A1001 ( 3.2A)
ZN  A1001 ( 2.4A)
BES  A1017 (-4.2A)
0.78A20.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1O86_A_LPRA702_1
(ANGIOTENSIN
CONVERTING ENZYME)		4pj6 LEUCYL-CYSTINYL
AMINOPEPTIDASE
(Homo
sapiens)		5 / 12HIS A 464
GLU A 465
HIS A 468
GLU A 487
PHE A 550
 ZN  A1101 ( 3.2A)
LYS  A1102 (-3.4A)
ZN  A1101 (-3.2A)
ZN  A1101 ( 1.9A)
None
1.31A21.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1O86_A_LPRA702_1
(ANGIOTENSIN
CONVERTING ENZYME)		4pj6 LEUCYL-CYSTINYL
AMINOPEPTIDASE
(Homo
sapiens)		5 / 12HIS A 464
GLU A 465
HIS A 468
GLU A 487
TYR A 549
 ZN  A1101 ( 3.2A)
LYS  A1102 (-3.4A)
ZN  A1101 (-3.2A)
ZN  A1101 ( 1.9A)
None
0.89A21.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1O86_A_LPRA702_1
(ANGIOTENSIN
CONVERTING ENZYME)		4wgk NEUTRAL CERAMIDASE
(Homo
sapiens)		5 / 12GLN A 471
HIS A 303
HIS A 194
GLU A 540
TYR A 579
None
ZN  A 801 ( 3.2A)
ZN  A 801 ( 3.3A)
ZN  A 801 ( 2.0A)
ZN  A 801 ( 4.3A)
1.14A21.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1O86_A_LPRA702_1
(ANGIOTENSIN
CONVERTING ENZYME)		5j6s ENDOPLASMIC
RETICULUM
AMINOPEPTIDASE 2
(Homo
sapiens)		5 / 12HIS A 370
GLU A 371
HIS A 374
GLU A 393
TYR A 455
 ZN  A1001 ( 3.2A)
6GA  A1015 (-3.0A)
ZN  A1001 ( 3.2A)
ZN  A1001 ( 1.7A)
6GA  A1015 (-4.0A)
0.74A21.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1O86_A_LPRA702_2
(ANGIOTENSIN
CONVERTING ENZYME)		1jmc PROTEIN (REPLICATION
PROTEIN A (RPA))
(Homo
sapiens)		4 / 4SER A 207
VAL A 203
PHE A 246
VAL A 242
None
1.49A17.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1O86_A_LPRA702_2
(ANGIOTENSIN
CONVERTING ENZYME)		1jmy BILE-SALT-ACTIVATED
LIPASE
(Homo
sapiens)		4 / 4SER A 422
VAL A 431
PHE A 418
VAL A 460
None
1.34A22.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1O86_A_LPRA702_2
(ANGIOTENSIN
CONVERTING ENZYME)		2akz GAMMA ENOLASE
(Homo
sapiens)		4 / 4SER A 114
VAL A  21
PHE A 379
VAL A 343
None
1.41A22.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1O86_A_LPRA702_2
(ANGIOTENSIN
CONVERTING ENZYME)		2bzl TYROSINE-PROTEIN
PHOSPHATASE,
NON-RECEPTOR TYPE 14
(Homo
sapiens)		4 / 4SER A1134
VAL A1149
PHE A1172
VAL A1086
None
1.44A19.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1O86_A_LPRA702_2
(ANGIOTENSIN
CONVERTING ENZYME)		2xsx BETA-ENOLASE
(Homo
sapiens)		4 / 4SER A 115
VAL A  22
PHE A 380
VAL A 344
None
1.34A21.30
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1O86_A_LPRA702_2
(ANGIOTENSIN
CONVERTING ENZYME)		2xy9 ANGIOTENSIN-CONVERTI
NG ENZYME
(Homo
sapiens)		4 / 4SER A 355
VAL A 380
PHE A 512
VAL A 518
3ES  A1636 (-4.3A)
3ES  A1635 (-3.9A)
3ES  A1635 (-4.8A)
3ES  A1636 (-4.1A)
0.15A99.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1O86_A_LPRA702_2
(ANGIOTENSIN
CONVERTING ENZYME)		3b97 ALPHA-ENOLASE
(Homo
sapiens)		4 / 4SER A 114
VAL A  21
PHE A 379
VAL A 343
None
1.41A21.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1O86_A_LPRA702_2
(ANGIOTENSIN
CONVERTING ENZYME)		3kv4 PHD FINGER PROTEIN 8
(Homo
sapiens)		4 / 4SER A 192
VAL A 231
PHE A 359
VAL A  16
None
1.18A19.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1O86_A_LPRA702_2
(ANGIOTENSIN
CONVERTING ENZYME)		4k3j HEPATOCYTE GROWTH
FACTOR BETA CHAIN
(Homo
sapiens)		4 / 4SER B 443
VAL B 345
PHE B 462
VAL B 504
None
1.14A23.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1O86_A_LPRA702_2
(ANGIOTENSIN
CONVERTING ENZYME)		4n49 CAP-SPECIFIC MRNA
(NUCLEOSIDE-2'-O-)-M
ETHYLTRANSFERASE 1
(Homo
sapiens)		4 / 4SER A 413
VAL A 481
PHE A 388
VAL A 444
None
1.19A21.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1O86_A_LPRA702_2
(ANGIOTENSIN
CONVERTING ENZYME)		4zg7 ECTONUCLEOTIDE
PYROPHOSPHATASE/PHOS
PHODIESTERASE FAMILY
MEMBER 2
(Homo
sapiens)		4 / 4SER A 735
VAL A 703
PHE A 716
VAL A 721
None
1.44A20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2C6N_A_LPRA705_1
(ANGIOTENSIN-CONVERTI
NG ENZYME, SOMATIC
ISOFORM)		2o36 THIMET
OLIGOPEPTIDASE
(Homo
sapiens)		5 / 12ALA A 425
HIS A 473
GLU A 474
HIS A 477
GLU A 502
None
ZN  A 690 (-3.4A)
ZN  A 690 ( 4.1A)
ZN  A 690 (-3.3A)
ZN  A 690 (-2.3A)
0.55A23.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2C6N_A_LPRA705_1
(ANGIOTENSIN-CONVERTI
NG ENZYME, SOMATIC
ISOFORM)		2o36 THIMET
OLIGOPEPTIDASE
(Homo
sapiens)		5 / 12ALA A 425
HIS A 473
GLU A 474
HIS A 477
TYR A 612
None
ZN  A 690 (-3.4A)
ZN  A 690 ( 4.1A)
ZN  A 690 (-3.3A)
None
1.24A23.10
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2C6N_A_LPRA705_1
(ANGIOTENSIN-CONVERTI
NG ENZYME, SOMATIC
ISOFORM)		2xy9 ANGIOTENSIN-CONVERTI
NG ENZYME
(Homo
sapiens)		11 / 12GLN A 281
HIS A 353
ALA A 354
HIS A 383
GLU A 384
HIS A 387
GLU A 411
LYS A 511
HIS A 513
TYR A 520
TYR A 523
3ES  A1635 (-3.3A)
3ES  A1635 (-3.8A)
3ES  A1635 (-4.2A)
ZN  A1628 ( 3.2A)
3ES  A1635 (-2.8A)
ZN  A1628 ( 3.2A)
ZN  A1628 ( 2.4A)
3ES  A1635 (-2.6A)
3ES  A1635 (-3.9A)
3ES  A1635 (-4.7A)
3ES  A1635 (-3.4A)
0.33A55.13
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2C6N_A_LPRA705_1
(ANGIOTENSIN-CONVERTI
NG ENZYME, SOMATIC
ISOFORM)		2xy9 ANGIOTENSIN-CONVERTI
NG ENZYME
(Homo
sapiens)		6 / 12HIS A 353
GLN A 369
LYS A 511
HIS A 513
TYR A 520
TYR A 523
3ES  A1635 (-3.8A)
None
3ES  A1635 (-2.6A)
3ES  A1635 (-3.9A)
3ES  A1635 (-4.7A)
3ES  A1635 (-3.4A)
1.25A55.13
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2C6N_A_LPRA705_1
(ANGIOTENSIN-CONVERTI
NG ENZYME, SOMATIC
ISOFORM)		2xyd ANGIOTENSIN-CONVERTI
NG ENZYME
(Homo
sapiens)		11 / 12GLN A 259
HIS A 331
ALA A 332
HIS A 361
GLU A 362
HIS A 365
GLU A 389
LYS A 489
HIS A 491
TYR A 498
TYR A 501
3ES  A1611 (-3.1A)
3ES  A1611 (-3.8A)
3ES  A1611 (-4.3A)
3ES  A1611 ( 3.2A)
3ES  A1611 (-2.5A)
ZN  A1620 ( 3.2A)
ZN  A1620 ( 2.4A)
3ES  A1611 (-2.6A)
3ES  A1611 (-3.9A)
3ES  A1611 (-4.7A)
3ES  A1611 (-3.5A)
0.34A98.85
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2C6N_A_LPRA705_1
(ANGIOTENSIN-CONVERTI
NG ENZYME, SOMATIC
ISOFORM)		2xyd ANGIOTENSIN-CONVERTI
NG ENZYME
(Homo
sapiens)		11 / 12GLN A 259
HIS A 331
GLN A 355
HIS A 361
GLU A 362
HIS A 365
GLU A 389
LYS A 489
HIS A 491
TYR A 498
TYR A 501
3ES  A1611 (-3.1A)
3ES  A1611 (-3.8A)
None
3ES  A1611 ( 3.2A)
3ES  A1611 (-2.5A)
ZN  A1620 ( 3.2A)
ZN  A1620 ( 2.4A)
3ES  A1611 (-2.6A)
3ES  A1611 (-3.9A)
3ES  A1611 (-4.7A)
3ES  A1611 (-3.5A)
0.49A98.85
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2C6N_A_LPRA705_1
(ANGIOTENSIN-CONVERTI
NG ENZYME, SOMATIC
ISOFORM)		2xyd ANGIOTENSIN-CONVERTI
NG ENZYME
(Homo
sapiens)		8 / 12HIS A 331
ALA A 332
HIS A 365
GLU A 362
GLU A 389
HIS A 491
TYR A 498
TYR A 501
3ES  A1611 (-3.8A)
3ES  A1611 (-4.3A)
ZN  A1620 ( 3.2A)
3ES  A1611 (-2.5A)
ZN  A1620 ( 2.4A)
3ES  A1611 (-3.9A)
3ES  A1611 (-4.7A)
3ES  A1611 (-3.5A)
1.46A98.85
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2C6N_A_LPRA705_1
(ANGIOTENSIN-CONVERTI
NG ENZYME, SOMATIC
ISOFORM)		2xyd ANGIOTENSIN-CONVERTI
NG ENZYME
(Homo
sapiens)		6 / 12HIS A 331
GLN A 347
HIS A 365
HIS A 491
TYR A 498
TYR A 501
3ES  A1611 (-3.8A)
None
ZN  A1620 ( 3.2A)
3ES  A1611 (-3.9A)
3ES  A1611 (-4.7A)
3ES  A1611 (-3.5A)
1.37A98.85
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2C6N_A_LPRA705_1
(ANGIOTENSIN-CONVERTI
NG ENZYME, SOMATIC
ISOFORM)		2xyd ANGIOTENSIN-CONVERTI
NG ENZYME
(Homo
sapiens)		6 / 12HIS A 331
GLN A 347
LYS A 489
HIS A 491
TYR A 498
TYR A 501
3ES  A1611 (-3.8A)
None
3ES  A1611 (-2.6A)
3ES  A1611 (-3.9A)
3ES  A1611 (-4.7A)
3ES  A1611 (-3.5A)
1.26A98.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2C6N_A_LPRA705_1
(ANGIOTENSIN-CONVERTI
NG ENZYME, SOMATIC
ISOFORM)		2yd0 ENDOPLASMIC
RETICULUM
AMINOPEPTIDASE 1
(Homo
sapiens)		6 / 12ALA A 318
HIS A 353
GLU A 354
HIS A 357
GLU A 376
TYR A 438
BES  A1950 (-4.9A)
ZN  A1946 ( 3.3A)
BES  A1950 (-3.3A)
BES  A1950 ( 3.3A)
ZN  A1946 ( 2.1A)
BES  A1950 (-4.3A)
0.72A21.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2C6N_A_LPRA705_1
(ANGIOTENSIN-CONVERTI
NG ENZYME, SOMATIC
ISOFORM)		3dwb ENDOTHELIN-CONVERTIN
G ENZYME 1
(Homo
sapiens)		5 / 12ALA A 567
HIS A 607
GLU A 608
HIS A 611
GLU A 667
RDF  A 817 (-4.4A)
ZN  A 771 ( 3.4A)
RDF  A 817 (-2.4A)
ZN  A 771 ( 3.3A)
ZN  A 771 ( 2.1A)
0.38A22.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2C6N_A_LPRA705_1
(ANGIOTENSIN-CONVERTI
NG ENZYME, SOMATIC
ISOFORM)		3u9w LEUKOTRIENE A-4
HYDROLASE
(Homo
sapiens)		5 / 12HIS A1295
GLU A1296
HIS A1299
GLU A1318
TYR A1383
 ZN  A2001 ( 3.2A)
28P  A7001 (-2.6A)
ZN  A2001 ( 3.2A)
ZN  A2001 ( 2.2A)
28P  A7001 (-4.6A)
0.63A21.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2C6N_A_LPRA705_1
(ANGIOTENSIN-CONVERTI
NG ENZYME, SOMATIC
ISOFORM)		3zus BOTULINUM NEUROTOXIN
TYPE A,
SYNAPTOSOMAL-ASSOCIA
TED PROTEIN 23
(Clostridium
botulinum;
Homo
sapiens)		5 / 12HIS A 223
GLU A 224
HIS A 227
GLU A 262
TYR A 366
 ZN  A1916 (-3.3A)
ZN  A1916 ( 4.3A)
ZN  A1916 (-3.3A)
ZN  A1916 (-2.0A)
None
0.83A20.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2C6N_A_LPRA705_1
(ANGIOTENSIN-CONVERTI
NG ENZYME, SOMATIC
ISOFORM)		4fys AMINOPEPTIDASE N
(Homo
sapiens)		6 / 12ALA A 353
HIS A 388
GLU A 389
HIS A 392
GLU A 411
TYR A 477
None
0.74A20.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2C6N_A_LPRA705_1
(ANGIOTENSIN-CONVERTI
NG ENZYME, SOMATIC
ISOFORM)		4kxb GLUTAMYL
AMINOPEPTIDASE
(Homo
sapiens)		6 / 12ALA A 358
HIS A 393
GLU A 394
HIS A 397
GLU A 416
TYR A 479
BES  A1017 (-4.6A)
ZN  A1001 ( 3.3A)
BES  A1017 (-3.1A)
ZN  A1001 ( 3.2A)
ZN  A1001 ( 2.4A)
BES  A1017 (-4.2A)
0.75A21.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2C6N_A_LPRA705_1
(ANGIOTENSIN-CONVERTI
NG ENZYME, SOMATIC
ISOFORM)		4nge PRESEQUENCE
PROTEASE,
MITOCHONDRIAL
(Homo
sapiens)		5 / 12ALA D 137
HIS D 108
HIS D 104
GLU D 205
TYR D 906
None
0.57A20.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2C6N_A_LPRA705_1
(ANGIOTENSIN-CONVERTI
NG ENZYME, SOMATIC
ISOFORM)		4pj6 LEUCYL-CYSTINYL
AMINOPEPTIDASE
(Homo
sapiens)		5 / 12HIS A 464
GLU A 465
HIS A 468
GLU A 487
TYR A 549
 ZN  A1101 ( 3.2A)
LYS  A1102 (-3.4A)
ZN  A1101 (-3.2A)
ZN  A1101 ( 1.9A)
None
0.81A23.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2C6N_A_LPRA705_1
(ANGIOTENSIN-CONVERTI
NG ENZYME, SOMATIC
ISOFORM)		4wgk NEUTRAL CERAMIDASE
(Homo
sapiens)		5 / 12GLN A 471
HIS A 303
HIS A 194
GLU A 540
TYR A 579
None
ZN  A 801 ( 3.2A)
ZN  A 801 ( 3.3A)
ZN  A 801 ( 2.0A)
ZN  A 801 ( 4.3A)
1.11A22.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2C6N_A_LPRA705_1
(ANGIOTENSIN-CONVERTI
NG ENZYME, SOMATIC
ISOFORM)		5j6s ENDOPLASMIC
RETICULUM
AMINOPEPTIDASE 2
(Homo
sapiens)		6 / 12ALA A 335
HIS A 370
GLU A 371
HIS A 374
GLU A 393
TYR A 455
6GA  A1015 (-4.7A)
ZN  A1001 ( 3.2A)
6GA  A1015 (-3.0A)
ZN  A1001 ( 3.2A)
ZN  A1001 ( 1.7A)
6GA  A1015 (-4.0A)
0.73A20.49
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2C6N_B_LPRB705_1
(ANGIOTENSIN-CONVERTI
NG ENZYME, SOMATIC
ISOFORM)		2xy9 ANGIOTENSIN-CONVERTI
NG ENZYME
(Homo
sapiens)		10 / 12GLN A 281
HIS A 353
HIS A 383
GLU A 384
HIS A 387
GLU A 411
LYS A 511
HIS A 513
TYR A 520
TYR A 523
3ES  A1635 (-3.3A)
3ES  A1635 (-3.8A)
ZN  A1628 ( 3.2A)
3ES  A1635 (-2.8A)
ZN  A1628 ( 3.2A)
ZN  A1628 ( 2.4A)
3ES  A1635 (-2.6A)
3ES  A1635 (-3.9A)
3ES  A1635 (-4.7A)
3ES  A1635 (-3.4A)
0.29A55.13
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2C6N_B_LPRB705_1
(ANGIOTENSIN-CONVERTI
NG ENZYME, SOMATIC
ISOFORM)		2xyd ANGIOTENSIN-CONVERTI
NG ENZYME
(Homo
sapiens)		11 / 12GLN A 259
HIS A 331
HIS A 361
GLU A 362
HIS A 365
GLU A 389
LYS A 489
HIS A 491
THR A 496
TYR A 498
TYR A 501
3ES  A1611 (-3.1A)
3ES  A1611 (-3.8A)
3ES  A1611 ( 3.2A)
3ES  A1611 (-2.5A)
ZN  A1620 ( 3.2A)
ZN  A1620 ( 2.4A)
3ES  A1611 (-2.6A)
3ES  A1611 (-3.9A)
3ES  A1611 (-3.4A)
3ES  A1611 (-4.7A)
3ES  A1611 (-3.5A)
0.36A98.85
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2C6N_B_LPRB705_1
(ANGIOTENSIN-CONVERTI
NG ENZYME, SOMATIC
ISOFORM)		2xyd ANGIOTENSIN-CONVERTI
NG ENZYME
(Homo
sapiens)		8 / 12HIS A 331
HIS A 365
GLU A 362
GLU A 389
HIS A 491
THR A 496
TYR A 498
TYR A 501
3ES  A1611 (-3.8A)
ZN  A1620 ( 3.2A)
3ES  A1611 (-2.5A)
ZN  A1620 ( 2.4A)
3ES  A1611 (-3.9A)
3ES  A1611 (-3.4A)
3ES  A1611 (-4.7A)
3ES  A1611 (-3.5A)
1.46A98.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2C6N_B_LPRB705_1
(ANGIOTENSIN-CONVERTI
NG ENZYME, SOMATIC
ISOFORM)		2yd0 ENDOPLASMIC
RETICULUM
AMINOPEPTIDASE 1
(Homo
sapiens)		5 / 12HIS A 353
GLU A 354
HIS A 357
GLU A 376
TYR A 438
 ZN  A1946 ( 3.3A)
BES  A1950 (-3.3A)
BES  A1950 ( 3.3A)
ZN  A1946 ( 2.1A)
BES  A1950 (-4.3A)
0.80A21.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2C6N_B_LPRB705_1
(ANGIOTENSIN-CONVERTI
NG ENZYME, SOMATIC
ISOFORM)		3u9w LEUKOTRIENE A-4
HYDROLASE
(Homo
sapiens)		5 / 12HIS A1295
GLU A1296
HIS A1299
GLU A1318
TYR A1383
 ZN  A2001 ( 3.2A)
28P  A7001 (-2.6A)
ZN  A2001 ( 3.2A)
ZN  A2001 ( 2.2A)
28P  A7001 (-4.6A)
0.67A21.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2C6N_B_LPRB705_1
(ANGIOTENSIN-CONVERTI
NG ENZYME, SOMATIC
ISOFORM)		3zus BOTULINUM NEUROTOXIN
TYPE A,
SYNAPTOSOMAL-ASSOCIA
TED PROTEIN 23
(Clostridium
botulinum;
Homo
sapiens)		5 / 12HIS A 223
GLU A 224
HIS A 227
GLU A 262
TYR A 366
 ZN  A1916 (-3.3A)
ZN  A1916 ( 4.3A)
ZN  A1916 (-3.3A)
ZN  A1916 (-2.0A)
None
0.86A20.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2C6N_B_LPRB705_1
(ANGIOTENSIN-CONVERTI
NG ENZYME, SOMATIC
ISOFORM)		4fys AMINOPEPTIDASE N
(Homo
sapiens)		5 / 12HIS A 388
GLU A 389
HIS A 392
GLU A 411
TYR A 477
None
0.83A20.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2C6N_B_LPRB705_1
(ANGIOTENSIN-CONVERTI
NG ENZYME, SOMATIC
ISOFORM)		4kxb GLUTAMYL
AMINOPEPTIDASE
(Homo
sapiens)		5 / 12HIS A 393
GLU A 394
HIS A 397
GLU A 416
TYR A 479
 ZN  A1001 ( 3.3A)
BES  A1017 (-3.1A)
ZN  A1001 ( 3.2A)
ZN  A1001 ( 2.4A)
BES  A1017 (-4.2A)
0.82A21.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2C6N_B_LPRB705_1
(ANGIOTENSIN-CONVERTI
NG ENZYME, SOMATIC
ISOFORM)		4pj6 LEUCYL-CYSTINYL
AMINOPEPTIDASE
(Homo
sapiens)		5 / 12HIS A 464
GLU A 465
HIS A 468
GLU A 487
TYR A 549
 ZN  A1101 ( 3.2A)
LYS  A1102 (-3.4A)
ZN  A1101 (-3.2A)
ZN  A1101 ( 1.9A)
None
0.87A23.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2C6N_B_LPRB705_1
(ANGIOTENSIN-CONVERTI
NG ENZYME, SOMATIC
ISOFORM)		4wgk NEUTRAL CERAMIDASE
(Homo
sapiens)		5 / 12GLN A 471
HIS A 303
HIS A 194
GLU A 540
TYR A 579
None
ZN  A 801 ( 3.2A)
ZN  A 801 ( 3.3A)
ZN  A 801 ( 2.0A)
ZN  A 801 ( 4.3A)
1.21A22.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2C6N_B_LPRB705_1
(ANGIOTENSIN-CONVERTI
NG ENZYME, SOMATIC
ISOFORM)		5j6s ENDOPLASMIC
RETICULUM
AMINOPEPTIDASE 2
(Homo
sapiens)		5 / 12HIS A 370
GLU A 371
HIS A 374
GLU A 393
TYR A 455
 ZN  A1001 ( 3.2A)
6GA  A1015 (-3.0A)
ZN  A1001 ( 3.2A)
ZN  A1001 ( 1.7A)
6GA  A1015 (-4.0A)
0.82A20.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2C6N_B_LPRB705_2
(ANGIOTENSIN-CONVERTI
NG ENZYME, SOMATIC
ISOFORM)		1r47 ALPHA-GALACTOSIDASE
A
(Homo
sapiens)		3 / 3ALA A 156
THR A 194
PHE A 169
None
0.71A21.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2C6N_B_LPRB705_2
(ANGIOTENSIN-CONVERTI
NG ENZYME, SOMATIC
ISOFORM)		2cqy PROPIONYL-COA
CARBOXYLASE ALPHA
CHAIN, MITOCHONDRIAL
(Homo
sapiens)		3 / 3ALA A  37
THR A  70
PHE A  27
None
0.69A11.04
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2C6N_B_LPRB705_2
(ANGIOTENSIN-CONVERTI
NG ENZYME, SOMATIC
ISOFORM)		2xyd ANGIOTENSIN-CONVERTI
NG ENZYME
(Homo
sapiens)		3 / 3ALA A 332
THR A 358
PHE A 490
3ES  A1611 (-4.3A)
3ES  A1611 (-3.6A)
3ES  A1611 (-4.7A)
0.24A98.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2C6N_B_LPRB705_2
(ANGIOTENSIN-CONVERTI
NG ENZYME, SOMATIC
ISOFORM)		3egi TRIMETHYLGUANOSINE
SYNTHASE HOMOLOG
(Homo
sapiens)		3 / 3ALA A 682
THR A 711
PHE A 761
None
0.72A16.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2C6N_B_LPRB705_2
(ANGIOTENSIN-CONVERTI
NG ENZYME, SOMATIC
ISOFORM)		3gdh TRIMETHYLGUANOSINE
SYNTHASE HOMOLOG
(Homo
sapiens)		3 / 3ALA A 682
THR A 711
PHE A 761
None
0.63A16.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2C6N_B_LPRB705_2
(ANGIOTENSIN-CONVERTI
NG ENZYME, SOMATIC
ISOFORM)		3hym CELL DIVISION CYCLE
PROTEIN 16 HOMOLOG
(Homo
sapiens)		3 / 3ALA B 412
THR B 420
PHE B 391
None
0.63A19.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2C6N_B_LPRB705_2
(ANGIOTENSIN-CONVERTI
NG ENZYME, SOMATIC
ISOFORM)		3nuu PKB-LIKE
(Homo
sapiens)		3 / 3ALA A 309
THR A 182
PHE A 301
None
None
SO4  A   1 ( 4.9A)
0.79A21.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2C6N_B_LPRB705_2
(ANGIOTENSIN-CONVERTI
NG ENZYME, SOMATIC
ISOFORM)		4f92 U5 SMALL NUCLEAR
RIBONUCLEOPROTEIN
200 KDA HELICASE
(Homo
sapiens)		3 / 3ALA B1497
THR B1511
PHE B1759
None
0.78A15.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2C6N_B_LPRB705_2
(ANGIOTENSIN-CONVERTI
NG ENZYME, SOMATIC
ISOFORM)		4krf PROTEIN ARGONAUTE-1
(Homo
sapiens)		3 / 3ALA A 219
THR A 366
PHE A 222
 A  R   7 ( 3.6A)
A  R   7 ( 3.5A)
None
0.67A21.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2C6N_B_LPRB705_2
(ANGIOTENSIN-CONVERTI
NG ENZYME, SOMATIC
ISOFORM)		4ni2 GUANYLATE CYCLASE
SOLUBLE SUBUNIT
BETA-1
(Homo
sapiens)		3 / 3ALA B 493
THR B 525
PHE B 582
None
0.75A16.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2C6N_B_LPRB705_2
(ANGIOTENSIN-CONVERTI
NG ENZYME, SOMATIC
ISOFORM)		5f8p ALPHA-KETOGLUTARATE-
DEPENDENT
DIOXYGENASE FTO
(Homo
sapiens)		3 / 3ALA A  68
THR A 138
PHE A 317
None
0.73A23.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2C6N_B_LPRB705_2
(ANGIOTENSIN-CONVERTI
NG ENZYME, SOMATIC
ISOFORM)		6ces RAS-RELATED
GTP-BINDING PROTEIN
A
(Homo
sapiens)		3 / 3ALA A 172
THR A 162
PHE A 123
None
0.73A8.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2C6N_B_LPRB705_2
(ANGIOTENSIN-CONVERTI
NG ENZYME, SOMATIC
ISOFORM)		6g5i RNA-BINDING PROTEIN
PNO1
(Homo
sapiens)		3 / 3ALA x 221
THR x 200
PHE x 163
None
0.77A9.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X91_A_LPRA1615_1
(ANGIOTENSIN
CONVERTING ENZYME)		2o36 THIMET
OLIGOPEPTIDASE
(Homo
sapiens)		5 / 12HIS A 473
GLU A 474
HIS A 477
GLU A 502
TYR A 612
 ZN  A 690 (-3.4A)
ZN  A 690 ( 4.1A)
ZN  A 690 (-3.3A)
ZN  A 690 (-2.3A)
None
1.13A22.76
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2X91_A_LPRA1615_1
(ANGIOTENSIN
CONVERTING ENZYME)		2xy9 ANGIOTENSIN-CONVERTI
NG ENZYME
(Homo
sapiens)		11 / 12GLN A 281
HIS A 353
HIS A 383
GLU A 384
HIS A 387
GLU A 411
LYS A 511
HIS A 513
VAL A 518
TYR A 520
TYR A 523
3ES  A1635 (-3.3A)
3ES  A1635 (-3.8A)
ZN  A1628 ( 3.2A)
3ES  A1635 (-2.8A)
ZN  A1628 ( 3.2A)
ZN  A1628 ( 2.4A)
3ES  A1635 (-2.6A)
3ES  A1635 (-3.9A)
3ES  A1636 (-4.1A)
3ES  A1635 (-4.7A)
3ES  A1635 (-3.4A)
0.28A44.26
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2X91_A_LPRA1615_1
(ANGIOTENSIN
CONVERTING ENZYME)		2xy9 ANGIOTENSIN-CONVERTI
NG ENZYME
(Homo
sapiens)		9 / 12HIS A 353
GLU A 384
HIS A 383
GLU A 411
LYS A 511
HIS A 513
VAL A 518
TYR A 520
TYR A 523
3ES  A1635 (-3.8A)
3ES  A1635 (-2.8A)
ZN  A1628 ( 3.2A)
ZN  A1628 ( 2.4A)
3ES  A1635 (-2.6A)
3ES  A1635 (-3.9A)
3ES  A1636 (-4.1A)
3ES  A1635 (-4.7A)
3ES  A1635 (-3.4A)
1.40A44.26
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2X91_A_LPRA1615_1
(ANGIOTENSIN
CONVERTING ENZYME)		2xyd ANGIOTENSIN-CONVERTI
NG ENZYME
(Homo
sapiens)		10 / 12GLN A 259
HIS A 331
HIS A 361
GLU A 362
HIS A 365
GLU A 389
LYS A 489
HIS A 491
TYR A 498
TYR A 501
3ES  A1611 (-3.1A)
3ES  A1611 (-3.8A)
3ES  A1611 ( 3.2A)
3ES  A1611 (-2.5A)
ZN  A1620 ( 3.2A)
ZN  A1620 ( 2.4A)
3ES  A1611 (-2.6A)
3ES  A1611 (-3.9A)
3ES  A1611 (-4.7A)
3ES  A1611 (-3.5A)
0.22A40.68
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2X91_A_LPRA1615_1
(ANGIOTENSIN
CONVERTING ENZYME)		2xyd ANGIOTENSIN-CONVERTI
NG ENZYME
(Homo
sapiens)		8 / 12HIS A 331
GLU A 362
HIS A 361
GLU A 389
LYS A 489
HIS A 491
TYR A 498
TYR A 501
3ES  A1611 (-3.8A)
3ES  A1611 (-2.5A)
3ES  A1611 ( 3.2A)
ZN  A1620 ( 2.4A)
3ES  A1611 (-2.6A)
3ES  A1611 (-3.9A)
3ES  A1611 (-4.7A)
3ES  A1611 (-3.5A)
1.43A40.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X91_A_LPRA1615_1
(ANGIOTENSIN
CONVERTING ENZYME)		2yd0 ENDOPLASMIC
RETICULUM
AMINOPEPTIDASE 1
(Homo
sapiens)		5 / 12HIS A 353
GLU A 354
HIS A 357
GLU A 376
TYR A 438
 ZN  A1946 ( 3.3A)
BES  A1950 (-3.3A)
BES  A1950 ( 3.3A)
ZN  A1946 ( 2.1A)
BES  A1950 (-4.3A)
0.72A22.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X91_A_LPRA1615_1
(ANGIOTENSIN
CONVERTING ENZYME)		3u9w LEUKOTRIENE A-4
HYDROLASE
(Homo
sapiens)		5 / 12HIS A1295
GLU A1296
HIS A1299
GLU A1318
TYR A1383
 ZN  A2001 ( 3.2A)
28P  A7001 (-2.6A)
ZN  A2001 ( 3.2A)
ZN  A2001 ( 2.2A)
28P  A7001 (-4.6A)
0.61A20.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X91_A_LPRA1615_1
(ANGIOTENSIN
CONVERTING ENZYME)		3zus BOTULINUM NEUROTOXIN
TYPE A,
SYNAPTOSOMAL-ASSOCIA
TED PROTEIN 23
(Clostridium
botulinum;
Homo
sapiens)		5 / 12HIS A 223
GLU A 224
HIS A 227
GLU A 262
TYR A 366
 ZN  A1916 (-3.3A)
ZN  A1916 ( 4.3A)
ZN  A1916 (-3.3A)
ZN  A1916 (-2.0A)
None
0.89A20.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X91_A_LPRA1615_1
(ANGIOTENSIN
CONVERTING ENZYME)		4fys AMINOPEPTIDASE N
(Homo
sapiens)		5 / 12HIS A 388
GLU A 389
HIS A 392
GLU A 411
TYR A 477
None
0.75A21.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X91_A_LPRA1615_1
(ANGIOTENSIN
CONVERTING ENZYME)		4kxb GLUTAMYL
AMINOPEPTIDASE
(Homo
sapiens)		5 / 12HIS A 393
GLU A 394
HIS A 397
GLU A 416
TYR A 479
 ZN  A1001 ( 3.3A)
BES  A1017 (-3.1A)
ZN  A1001 ( 3.2A)
ZN  A1001 ( 2.4A)
BES  A1017 (-4.2A)
0.75A21.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X91_A_LPRA1615_1
(ANGIOTENSIN
CONVERTING ENZYME)		4pj6 LEUCYL-CYSTINYL
AMINOPEPTIDASE
(Homo
sapiens)		5 / 12HIS A 464
GLU A 465
HIS A 468
GLU A 487
TYR A 549
 ZN  A1101 ( 3.2A)
LYS  A1102 (-3.4A)
ZN  A1101 (-3.2A)
ZN  A1101 ( 1.9A)
None
0.85A23.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X91_A_LPRA1615_1
(ANGIOTENSIN
CONVERTING ENZYME)		4v06 TRYPTOPHAN
5-HYDROXYLASE 2
(Homo
sapiens)		5 / 12HIS A 318
GLU A 319
HIS A 323
GLU A 363
TYR A 281
 FE  A1491 ( 3.5A)
IMD  A 600 (-3.3A)
FE  A1491 ( 3.3A)
FE  A1491 ( 2.0A)
None
1.41A19.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X91_A_LPRA1615_1
(ANGIOTENSIN
CONVERTING ENZYME)		4wgk NEUTRAL CERAMIDASE
(Homo
sapiens)		5 / 12GLN A 471
HIS A 303
HIS A 194
GLU A 540
TYR A 579
None
ZN  A 801 ( 3.2A)
ZN  A 801 ( 3.3A)
ZN  A 801 ( 2.0A)
ZN  A 801 ( 4.3A)
1.09A20.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X91_A_LPRA1615_1
(ANGIOTENSIN
CONVERTING ENZYME)		5j6s ENDOPLASMIC
RETICULUM
AMINOPEPTIDASE 2
(Homo
sapiens)		5 / 12HIS A 370
GLU A 371
HIS A 374
GLU A 393
TYR A 455
 ZN  A1001 ( 3.2A)
6GA  A1015 (-3.0A)
ZN  A1001 ( 3.2A)
ZN  A1001 ( 1.7A)
6GA  A1015 (-4.0A)
0.71A20.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X91_A_LPRA1615_2
(ANGIOTENSIN
CONVERTING ENZYME)		2vkw NEURAL CELL ADHESION
MOLECULE 1,140 KDA
ISOFORM
(Homo
sapiens)		3 / 3SER A 662
THR A 691
PHE A 687
None
0.72A17.35
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2X91_A_LPRA1615_2
(ANGIOTENSIN
CONVERTING ENZYME)		2xyd ANGIOTENSIN-CONVERTI
NG ENZYME
(Homo
sapiens)		3 / 3SER A 333
THR A 358
PHE A 435
3ES  A1611 (-4.4A)
3ES  A1611 (-3.6A)
3ES  A1611 ( 4.2A)
0.27A40.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X91_A_LPRA1615_2
(ANGIOTENSIN
CONVERTING ENZYME)		3jd8 NIEMANN-PICK C1
PROTEIN
(Homo
sapiens)		3 / 3SER A 491
THR A 536
PHE A 565
None
NAG  A1312 ( 4.3A)
None
0.76A18.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X91_A_LPRA1615_2
(ANGIOTENSIN
CONVERTING ENZYME)		4ay2 PROBABLE
ATP-DEPENDENT RNA
HELICASE DDX58
(Homo
sapiens)		3 / 3SER A 411
THR A 441
PHE A 776
None
0.71A24.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X91_A_LPRA1615_2
(ANGIOTENSIN
CONVERTING ENZYME)		4k8y KALLIKREIN-4
(Homo
sapiens)		3 / 3SER A 122
THR A 235
PHE A 181
None
0.69A16.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X91_A_LPRA1615_2
(ANGIOTENSIN
CONVERTING ENZYME)		4llv 4E10 FV LIGHT CHAIN
(Homo
sapiens)		3 / 3SER B  94
THR B  97
PHE B  71
None
0.54A15.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X91_A_LPRA1615_2
(ANGIOTENSIN
CONVERTING ENZYME)		4nsc CALCIUM UPTAKE
PROTEIN 1,
MITOCHONDRIAL
(Homo
sapiens)		3 / 3SER A 252
THR A 214
PHE A 206
None
0.64A21.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X91_A_LPRA1615_2
(ANGIOTENSIN
CONVERTING ENZYME)		4x6d T-CELL SURFACE
GLYCOPROTEIN CD1A
(Homo
sapiens)		3 / 3SER A  33
THR A  37
PHE A  70
None
None
OLA  A 304 ( 4.4A)
0.76A19.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X91_A_LPRA1615_2
(ANGIOTENSIN
CONVERTING ENZYME)		5ftg CHOLINE KINASE ALPHA
(Homo
sapiens)		3 / 3SER A 114
THR A  87
PHE A 200
EDO  A1463 (-2.8A)
None
None
0.78A22.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X91_A_LPRA1615_2
(ANGIOTENSIN
CONVERTING ENZYME)		5hns NIEMANN-PICK C1
PROTEIN
(Homo
sapiens)		3 / 3SER A 491
THR A 536
PHE A 565
None
NAG  A 710 ( 3.9A)
None
0.77A16.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X91_A_LPRA1615_2
(ANGIOTENSIN
CONVERTING ENZYME)		5nug CYTOPLASMIC DYNEIN 1
HEAVY CHAIN 1
(Homo
sapiens)		3 / 3SER A4214
THR A4221
PHE A1836
None
0.77A8.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X91_A_LPRA1615_2
(ANGIOTENSIN
CONVERTING ENZYME)		6fuy VINCULIN
(Homo
sapiens)		3 / 3SER A 112
THR A 119
PHE A   4
None
0.65A8.58