POTENTIAL TARGETS FROM HUMAN (RESULTS FROM SUB-STRUCTURAL SIMILARITY SEARCHES)
1) User may click on the DrReposER ID (the second column) to get information on the binding sites and drug molecule.
2) Click View (the second last column) to view matched residues and superposition in the NGL viewer (upper right part).
3) User may also click on the Dock (the last column) to get script for molecular docking in UCSF Chimera through AutoDock Vina.

DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6MN1_A_LLLA302_0
(AMINOGLYCOSIDE
N(3)-ACETYLTRANSFERA
SE)		1now BETA-HEXOSAMINIDASE
BETA CHAIN
(Homo
sapiens)		5 / 10ASP A 354
TRP A 405
GLY A 353
ASP A 317
THR A 295
IFG  A 557 (-3.6A)
IFG  A 557 (-3.3A)
None
None
None
1.33A10.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6MN1_A_LLLA302_0
(AMINOGLYCOSIDE
N(3)-ACETYLTRANSFERA
SE)		4gwn MEPRIN A SUBUNIT
BETA
(Homo
sapiens)		5 / 10ASP A 353
GLY A 349
ASP A 281
THR A 324
SER A 318
None
1.31A10.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6MN1_A_LLLA302_0
(AMINOGLYCOSIDE
N(3)-ACETYLTRANSFERA
SE)		4miv N-SULPHOGLUCOSAMINE
SULPHOHYDROLASE
(Homo
sapiens)		5 / 10TYR A 215
ASP A 179
THR A 242
THR A  47
SER A  37
None
1.49A10.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6MN1_A_LLLA302_0
(AMINOGLYCOSIDE
N(3)-ACETYLTRANSFERA
SE)		5szw ELAV-LIKE PROTEIN 1
(Homo
sapiens)		5 / 10TYR A  70
ASP A  75
GLY A  46
ASP A   9
THR A  82
None
1.39A20.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6MN1_B_LLLB302_0
(AMINOGLYCOSIDE
N(3)-ACETYLTRANSFERA
SE)		4gwn MEPRIN A SUBUNIT
BETA
(Homo
sapiens)		5 / 10ASP A 353
GLY A 349
ASP A 281
THR A 324
SER A 318
None
1.29A10.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6MN1_B_LLLB302_0
(AMINOGLYCOSIDE
N(3)-ACETYLTRANSFERA
SE)		4lxo FIBRONECTIN
(Homo
sapiens)		5 / 10ASP A1498
TYR A1393
ASP A1337
THR A1344
THR A1415
None
1.21A16.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6MN1_B_LLLB302_0
(AMINOGLYCOSIDE
N(3)-ACETYLTRANSFERA
SE)		4rh7 GREEN FLUORESCENT
PROTEIN/CYTOPLASMIC
DYNEIN 2 HEAVY CHAIN
1
(Homo
sapiens;
synthetic
construct)		5 / 10ASP A2360
GLY A2294
TYR A2432
ASP A2487
THR A2485
None
ADP  A4405 (-2.9A)
None
None
None
1.49A2.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6MN5_A_LLLA301_0
(AMINOGLYCOSIDE
N(3)-ACETYLTRANSFERA
SE, AAC(3)-IVA)		1bix AP ENDONUCLEASE 1
(Homo
sapiens)		4 / 6ASP A 283
TYR A 171
GLU A  96
ASP A  70
None
None
SM  A 401 (-2.3A)
SM  A 401 (-3.3A)
1.43A15.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6MN5_A_LLLA301_0
(AMINOGLYCOSIDE
N(3)-ACETYLTRANSFERA
SE, AAC(3)-IVA)		1wb0 CHITOTRIOSIDASE 1
(Homo
sapiens)		4 / 6ASP A 213
TYR A 141
GLU A 140
ASP A 138
None
1.31A11.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6MN5_A_LLLA301_0
(AMINOGLYCOSIDE
N(3)-ACETYLTRANSFERA
SE, AAC(3)-IVA)		2qag SEPTIN-2
(Homo
sapiens)		4 / 6TYR A 211
GLU A 289
ASP A 293
GLU A 297
None
1.46A11.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6MN5_A_LLLA301_0
(AMINOGLYCOSIDE
N(3)-ACETYLTRANSFERA
SE, AAC(3)-IVA)		3avs LYSINE-SPECIFIC
DEMETHYLASE 6A
(Homo
sapiens)		4 / 6TYR A1330
GLU A1337
CYH A1295
GLU A1257
None
None
EDO  A1508 (-2.3A)
EDO  A1508 (-2.9A)
1.44A9.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6MN5_A_LLLA301_0
(AMINOGLYCOSIDE
N(3)-ACETYLTRANSFERA
SE, AAC(3)-IVA)		3pja TRANSLIN
(Homo
sapiens)		4 / 6ASP A 139
TYR A  84
ASP A 128
GLU A 117
None
1.46A16.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6MN5_A_LLLA301_0
(AMINOGLYCOSIDE
N(3)-ACETYLTRANSFERA
SE, AAC(3)-IVA)		4gos V-SET
DOMAIN-CONTAINING
T-CELL ACTIVATION
INHIBITOR 1
(Homo
sapiens)		4 / 6ASP A 124
TYR A 128
ASP A  94
GLU A  95
None
1.45A20.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6MN5_A_LLLA301_0
(AMINOGLYCOSIDE
N(3)-ACETYLTRANSFERA
SE, AAC(3)-IVA)		4z2a FURIN
(Homo
sapiens)		4 / 6ASP A 264
TYR A 308
GLU A 236
GLU A 230
None
1.01A10.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6MN5_B_LLLB301_0
(AMINOGLYCOSIDE
N(3)-ACETYLTRANSFERA
SE, AAC(3)-IVA)		1pc2 MITOCHONDRIA FISSION
PROTEIN
(Homo
sapiens)		4 / 7ASP A  50
TYR A  38
GLU A  18
GLU A  12
None
1.15A18.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6MN5_B_LLLB301_0
(AMINOGLYCOSIDE
N(3)-ACETYLTRANSFERA
SE, AAC(3)-IVA)		1s1g POTASSIUM
VOLTAGE-GATED
CHANNEL SUBFAMILY D
MEMBER 3
(Homo
sapiens)		4 / 7ARG A 141
GLU A 142
ASP A 138
GLU A 134
None
1.03A19.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6MN5_B_LLLB301_0
(AMINOGLYCOSIDE
N(3)-ACETYLTRANSFERA
SE, AAC(3)-IVA)		1suv SEROTRANSFERRIN,
C-LOBE
(Homo
sapiens)		4 / 7ASP E 625
ARG E 629
GLU E 410
GLU E 413
None
1.24A15.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6MN5_B_LLLB301_0
(AMINOGLYCOSIDE
N(3)-ACETYLTRANSFERA
SE, AAC(3)-IVA)		2gzk SEX-DETERMINING
REGION ON Y / HMGB1
(Homo
sapiens;
Rattus
rattus)		4 / 7ASP A 134
TYR A 138
GLU A 102
GLU A 110
None
1.28A18.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6MN5_B_LLLB301_0
(AMINOGLYCOSIDE
N(3)-ACETYLTRANSFERA
SE, AAC(3)-IVA)		2r3a HISTONE-LYSINE
N-METHYLTRANSFERASE
SUV39H2
(Homo
sapiens)		4 / 7ASP A  57
TYR A 211
GLU A 172
ASP A 207
None
1.22A14.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6MN5_B_LLLB301_0
(AMINOGLYCOSIDE
N(3)-ACETYLTRANSFERA
SE, AAC(3)-IVA)		3dxb THIOREDOXIN
N-TERMINALLY FUSED
TO PUF60(UHM)
(Escherichia
coli;
Homo
sapiens)		4 / 7ASP A 553
TYR A 496
GLU A 498
GLU A 429
None
1.19A18.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6MN5_B_LLLB301_0
(AMINOGLYCOSIDE
N(3)-ACETYLTRANSFERA
SE, AAC(3)-IVA)		3ryt RAS-RELATED C3
BOTULINUM TOXIN
SUBSTRATE 1
(Homo
sapiens)		4 / 7ARG C  68
TYR C  72
ASP C  65
GLU C  62
None
1.27A20.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6MN5_B_LLLB301_0
(AMINOGLYCOSIDE
N(3)-ACETYLTRANSFERA
SE, AAC(3)-IVA)		4owt INTEGRATOR COMPLEX
SUBUNIT 3
(Homo
sapiens)		4 / 7ASP A 348
ARG A 304
CYH A 236
GLU A 232
None
1.29A9.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6MN5_B_LLLB301_0
(AMINOGLYCOSIDE
N(3)-ACETYLTRANSFERA
SE, AAC(3)-IVA)		5l3x NEGATIVE ELONGATION
FACTOR C/D
(Homo
sapiens)		4 / 7ASP B 335
ARG B 267
GLU B 271
GLU B 221
None
1.24A11.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6MN5_C_LLLC301_0
(AMINOGLYCOSIDE
N(3)-ACETYLTRANSFERA
SE, AAC(3)-IVA)		1cjl PROCATHEPSIN L
(Homo
sapiens)		4 / 6ASP A  84
TYR A  76
ASP A  55
GLU A  96
None
1.48A13.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6MN5_C_LLLC301_0
(AMINOGLYCOSIDE
N(3)-ACETYLTRANSFERA
SE, AAC(3)-IVA)		1pc2 MITOCHONDRIA FISSION
PROTEIN
(Homo
sapiens)		4 / 6ASP A  50
TYR A  38
GLU A  18
GLU A  12
None
1.12A18.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6MN5_C_LLLC301_0
(AMINOGLYCOSIDE
N(3)-ACETYLTRANSFERA
SE, AAC(3)-IVA)		1yx5 UBIQUITIN
(Homo
sapiens)		4 / 6ASP B  39
GLU B  24
ASP B  52
GLU B  51
None
1.15A21.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6MN5_C_LLLC301_0
(AMINOGLYCOSIDE
N(3)-ACETYLTRANSFERA
SE, AAC(3)-IVA)		4gos V-SET
DOMAIN-CONTAINING
T-CELL ACTIVATION
INHIBITOR 1
(Homo
sapiens)		4 / 6ASP A 124
TYR A 128
ASP A  94
GLU A  95
None
1.47A20.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6MN5_C_LLLC301_0
(AMINOGLYCOSIDE
N(3)-ACETYLTRANSFERA
SE, AAC(3)-IVA)		4z2a FURIN
(Homo
sapiens)		4 / 6ASP A 264
TYR A 308
GLU A 236
GLU A 230
None
0.98A10.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6MN5_D_LLLD301_0
(AMINOGLYCOSIDE
N(3)-ACETYLTRANSFERA
SE, AAC(3)-IVA)		1gz4 NAD-DEPENDENT MALIC
ENZYME
(Homo
sapiens)		4 / 6ARG A 165
GLU A 314
ASP A 279
GLU A 255
ATP  A 601 ( 3.2A)
ATP  A 601 (-4.1A)
MN  A 604 ( 2.6A)
MN  A 604 ( 3.3A)
1.48A9.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6MN5_D_LLLD301_0
(AMINOGLYCOSIDE
N(3)-ACETYLTRANSFERA
SE, AAC(3)-IVA)		1uwy CARBOXYPEPTIDASE M
(Homo
sapiens)		4 / 6ASP A  68
ARG A 127
GLU A 128
ASP A 134
None
ZN  A1405 ( 4.8A)
None
None
1.34A12.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6MN5_D_LLLD301_0
(AMINOGLYCOSIDE
N(3)-ACETYLTRANSFERA
SE, AAC(3)-IVA)		1yx5 UBIQUITIN
(Homo
sapiens)		4 / 6ASP B  39
GLU B  24
ASP B  52
GLU B  51
None
1.14A21.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6MN5_D_LLLD301_0
(AMINOGLYCOSIDE
N(3)-ACETYLTRANSFERA
SE, AAC(3)-IVA)		3f70 LETHAL(3)MALIGNANT
BRAIN TUMOR-LIKE 2
PROTEIN
(Homo
sapiens)		4 / 6ASP A 365
ARG A 551
GLU A 549
CYH A 554
None
None
MLZ  A  20 ( 4.2A)
MLZ  A  20 ( 4.1A)
1.45A13.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6MN5_D_LLLD301_0
(AMINOGLYCOSIDE
N(3)-ACETYLTRANSFERA
SE, AAC(3)-IVA)		4cgy DNA TOPOISOMERASE
3-ALPHA
(Homo
sapiens)		4 / 6ASP A 150
ARG A 364
GLU A 352
GLU A 540
 MG  A1640 ( 4.2A)
None
MG  A1640 ( 4.3A)
None
1.44A7.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6MN5_D_LLLD301_0
(AMINOGLYCOSIDE
N(3)-ACETYLTRANSFERA
SE, AAC(3)-IVA)		4jgh CULLIN-5
(Homo
sapiens)		4 / 6ASP D  20
ARG D  23
ASP D  68
GLU D  67
None
1.35A12.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6MN5_D_LLLD301_0
(AMINOGLYCOSIDE
N(3)-ACETYLTRANSFERA
SE, AAC(3)-IVA)		4owt INTEGRATOR COMPLEX
SUBUNIT 3
(Homo
sapiens)		4 / 6ASP A 348
ARG A 304
CYH A 236
GLU A 232
None
1.32A9.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6MN5_D_LLLD301_0
(AMINOGLYCOSIDE
N(3)-ACETYLTRANSFERA
SE, AAC(3)-IVA)		5jpn COMPLEMENT C4-A
COMPLEMENT C4-A
(Homo
sapiens;
Homo
sapiens)		4 / 6ASP B1304
ARG B1300
GLU C1563
GLU B 943
None
1.19A8.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6MN5_D_LLLD301_0
(AMINOGLYCOSIDE
N(3)-ACETYLTRANSFERA
SE, AAC(3)-IVA)		6ez8 HUNTINGTIN
FACTOR VIII INTRON
22 PROTEIN
(Homo
sapiens;
Homo
sapiens)		4 / 6ARG A1998
GLU B 331
ASP B 333
GLU B 335
None
1.43A15.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6MN5_E_LLLE301_0
(AMINOGLYCOSIDE
N(3)-ACETYLTRANSFERA
SE, AAC(3)-IVA)		1bf5 SIGNAL TRANSDUCER
AND ACTIVATOR OF
TRANSCRIPTION
1-ALPHA/BETA
(Homo
sapiens)		4 / 7ASP A 674
ARG A 649
ASP A 646
GLU A 705
None
1.32A10.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6MN5_E_LLLE301_0
(AMINOGLYCOSIDE
N(3)-ACETYLTRANSFERA
SE, AAC(3)-IVA)		2f15 5'-AMP-ACTIVATED
PROTEIN KINASE,
BETA-2 SUBUNIT
(Homo
sapiens)		4 / 7ASP A 111
GLU A  85
ASP A 136
GLU A 139
None
1.30A23.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6MN5_E_LLLE301_0
(AMINOGLYCOSIDE
N(3)-ACETYLTRANSFERA
SE, AAC(3)-IVA)		2ibu ACETYL-COA
ACETYLTRANSFERASE
(Homo
sapiens)		4 / 7ASP A 253
ARG A 393
GLU A 234
GLU A 351
None
1.06A14.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6MN5_E_LLLE301_0
(AMINOGLYCOSIDE
N(3)-ACETYLTRANSFERA
SE, AAC(3)-IVA)		2iik 3-KETOACYL-COA
THIOLASE,
PEROXISOMAL
(Homo
sapiens)		4 / 7ASP A 246
ARG A 386
GLU A 223
GLU A 344
None
1.20A10.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6MN5_E_LLLE301_0
(AMINOGLYCOSIDE
N(3)-ACETYLTRANSFERA
SE, AAC(3)-IVA)		2jll NEURAL CELL ADHESION
MOLECULE 2
(Homo
sapiens)		4 / 7ASP A 374
ARG A 336
TYR A 378
ASP A 339
None
1.24A12.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6MN5_E_LLLE301_0
(AMINOGLYCOSIDE
N(3)-ACETYLTRANSFERA
SE, AAC(3)-IVA)		2xy1 NEURAL CELL ADHESION
MOLECULE 2
(Homo
sapiens)		4 / 7ASP A 374
ARG A 336
TYR A 378
ASP A 339
None
1.24A16.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6MN5_E_LLLE301_0
(AMINOGLYCOSIDE
N(3)-ACETYLTRANSFERA
SE, AAC(3)-IVA)		2xyc NEURAL CELL ADHESION
MOLECULE 2
(Homo
sapiens)		4 / 7ASP A 374
ARG A 336
TYR A 378
ASP A 339
None
1.22A11.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6MN5_E_LLLE301_0
(AMINOGLYCOSIDE
N(3)-ACETYLTRANSFERA
SE, AAC(3)-IVA)		2ybx PHOSPHATIDYLINOSITOL
-5-PHOSPHATE
4-KINASE TYPE-2
ALPHA
(Homo
sapiens)		4 / 7ASP A 223
GLU A 220
ASP A 237
GLU A 241
None
1.28A11.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6MN5_E_LLLE301_0
(AMINOGLYCOSIDE
N(3)-ACETYLTRANSFERA
SE, AAC(3)-IVA)		3l4g PHENYLALANYL-TRNA
SYNTHETASE BETA
CHAIN
(Homo
sapiens)		4 / 7ASP B  21
ARG B   8
TYR B  63
ASP B   9
None
1.35A10.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6MN5_E_LLLE301_0
(AMINOGLYCOSIDE
N(3)-ACETYLTRANSFERA
SE, AAC(3)-IVA)		4c2k 3-KETOACYL-COA
THIOLASE,
MITOCHONDRIAL
(Homo
sapiens)		4 / 7ASP A 220
ARG A 360
GLU A 202
GLU A 318
None
1.04A11.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6MN5_E_LLLE301_0
(AMINOGLYCOSIDE
N(3)-ACETYLTRANSFERA
SE, AAC(3)-IVA)		4l7w HD DOMAIN-CONTAINING
PROTEIN 2
(Homo
sapiens)		4 / 7ASP A 143
ARG A  32
GLU A  81
ASP A  86
None
MG  A 302 ( 4.0A)
MG  A 303 ( 2.4A)
MG  A 301 ( 2.8A)
1.17A14.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6MN5_E_LLLE301_0
(AMINOGLYCOSIDE
N(3)-ACETYLTRANSFERA
SE, AAC(3)-IVA)		4nge PRESEQUENCE
PROTEASE,
MITOCHONDRIAL
(Homo
sapiens)		4 / 7GLU D 634
ASP D 631
CYH D 692
GLU D 695
None
0.98A6.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6MN5_E_LLLE301_0
(AMINOGLYCOSIDE
N(3)-ACETYLTRANSFERA
SE, AAC(3)-IVA)		4p5e 2'-DEOXYNUCLEOSIDE
5'-PHOSPHATE
N-HYDROLASE 1
(Homo
sapiens)		4 / 7TYR A 145
GLU A  93
ASP A  35
GLU A  34
None
1.37A21.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6MN5_E_LLLE301_0
(AMINOGLYCOSIDE
N(3)-ACETYLTRANSFERA
SE, AAC(3)-IVA)		5jpn COMPLEMENT C4-A
COMPLEMENT C4-A
(Homo
sapiens;
Homo
sapiens)		4 / 7ASP B1304
ARG B1300
GLU C1563
GLU B 943
None
1.13A8.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6MN5_E_LLLE301_0
(AMINOGLYCOSIDE
N(3)-ACETYLTRANSFERA
SE, AAC(3)-IVA)		5mrg TAR DNA-BINDING
PROTEIN 43
(Homo
sapiens)		4 / 7ARG A  18
TYR A  16
GLU A  29
GLU A  26
None
1.36A28.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6MN5_E_LLLE301_0
(AMINOGLYCOSIDE
N(3)-ACETYLTRANSFERA
SE, AAC(3)-IVA)		5ool 39S RIBOSOMAL
PROTEIN L38,
MITOCHONDRIAL
(Homo
sapiens)		4 / 7ASP 6 302
ARG 6 299
GLU 6 231
GLU 6 227
None
1.01A11.29