POTENTIAL TARGETS FROM HUMAN (RESULTS FROM SUB-STRUCTURAL SIMILARITY SEARCHES)
1) User may click on the DrReposER ID (the second column) to get information on the binding sites and drug molecule.
2) Click View (the second last column) to view matched residues and superposition in the NGL viewer (upper right part).
3) User may also click on the Dock (the last column) to get script for molecular docking in UCSF Chimera through AutoDock Vina.

DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K9F_F_LFXF0_1
(DNA TOPOISOMERASE 4
SUBUNIT A
DNA TOPOISOMERASE 4
SUBUNIT B)		1q1q SULFOTRANSFERASE
FAMILY, CYTOSOLIC,
2B, MEMBER 1 ISOFORM
A
(Homo
sapiens)		4 / 5SER A 108
ARG A 132
GLY A 131
GLU A 196
None
A3P  A 352 (-3.2A)
None
None
1.19A21.68
19.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K9F_F_LFXF0_1
(DNA TOPOISOMERASE 4
SUBUNIT A
DNA TOPOISOMERASE 4
SUBUNIT B)		1ybw HEPATOCYTE GROWTH
FACTOR ACTIVATOR
PRECURSOR
(Homo
sapiens)		4 / 5SER A 494
ARG A 624
GLY A 621
GLU A 545
None
1.05A19.01
17.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K9F_F_LFXF0_1
(DNA TOPOISOMERASE 4
SUBUNIT A
DNA TOPOISOMERASE 4
SUBUNIT B)		3kq4 CUBILIN
GASTRIC INTRINSIC
FACTOR
(Homo
sapiens)		4 / 5SER A 123
ARG B1377
GLY B1376
GLU B1379
None
None
CA  B2017 ( 4.4A)
None
1.31A21.77
20.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K9F_F_LFXF0_1
(DNA TOPOISOMERASE 4
SUBUNIT A
DNA TOPOISOMERASE 4
SUBUNIT B)		3ohm 1-PHOSPHATIDYLINOSIT
OL-4,5-BISPHOSPHATE
PHOSPHODIESTERASE
BETA-3
(Homo
sapiens)		4 / 5SER B 734
ARG B 223
GLY B 301
GLU B 303
None
0.96A19.96
15.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K9F_F_LFXF0_1
(DNA TOPOISOMERASE 4
SUBUNIT A
DNA TOPOISOMERASE 4
SUBUNIT B)		4qj4 1-PHOSPHATIDYLINOSIT
OL 4,5-BISPHOSPHATE
PHOSPHODIESTERASE
BETA-3
(Homo
sapiens)		4 / 5SER B 734
ARG B 223
GLY B 301
GLU B 303
None
1.02A20.38
17.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K9F_F_LFXF0_1
(DNA TOPOISOMERASE 4
SUBUNIT A
DNA TOPOISOMERASE 4
SUBUNIT B)		5hvf CARBOXYPEPTIDASE B2
(Homo
sapiens)		4 / 5ARG A 235
ARG A 302
GLY A 336
GLU A 338
FLC  A 509 (-2.8A)
None
None
None
1.17A21.43
20.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K9F_F_LFXF0_1
(DNA TOPOISOMERASE 4
SUBUNIT A
DNA TOPOISOMERASE 4
SUBUNIT B)		5iy7 TRANSCRIPTION
INITIATION FACTOR
IIB
(Homo
sapiens)		4 / 5SER M 216
ARG M 217
ARG M 169
GLY M 172
None
1.22A21.62
21.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K9F_F_LFXF0_1
(DNA TOPOISOMERASE 4
SUBUNIT A
DNA TOPOISOMERASE 4
SUBUNIT B)		5jzv ADENYLATE KINASE
ISOENZYME 6
(Homo
sapiens)		4 / 5SER A 135
ARG A  96
GLY A  10
GLU A 123
None
1.19A17.10
25.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K9F_F_LFXF0_1
(DNA TOPOISOMERASE 4
SUBUNIT A
DNA TOPOISOMERASE 4
SUBUNIT B)		5te6 HEAVY CHAIN OF N6
LIGHT CHAIN OF N6
(Homo
sapiens)		4 / 5SER L   9
ARG H  43
GLY H  44
GLU H  46
None
1.28A16.90
19.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K9F_H_LFXH0_1
(DNA TOPOISOMERASE 4
SUBUNIT A
DNA TOPOISOMERASE 4
SUBUNIT B)		1gs9 APOLIPOPROTEIN E
(Homo
sapiens)		4 / 6ARG A 147
ARG A 114
GLY A 113
GLU A 121
None
1.02A15.32
18.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K9F_H_LFXH0_1
(DNA TOPOISOMERASE 4
SUBUNIT A
DNA TOPOISOMERASE 4
SUBUNIT B)		1gzh TUMOR SUPPRESSOR
P53-BINDING PROTEIN
1
(Homo
sapiens)		4 / 6SER B1834
ARG B1781
GLY B1785
GLU B1789
None
1.05A19.60
17.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K9F_H_LFXH0_1
(DNA TOPOISOMERASE 4
SUBUNIT A
DNA TOPOISOMERASE 4
SUBUNIT B)		1ybw HEPATOCYTE GROWTH
FACTOR ACTIVATOR
PRECURSOR
(Homo
sapiens)		4 / 6SER A 494
ARG A 624
GLY A 621
GLU A 545
None
1.05A19.01
17.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K9F_H_LFXH0_1
(DNA TOPOISOMERASE 4
SUBUNIT A
DNA TOPOISOMERASE 4
SUBUNIT B)		2lkn AH
RECEPTOR-INTERACTING
PROTEIN
(Homo
sapiens)		4 / 6ARG A  81
GLY A  83
GLU A  20
GLU A  84
None
0.84A16.45
21.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K9F_H_LFXH0_1
(DNA TOPOISOMERASE 4
SUBUNIT A
DNA TOPOISOMERASE 4
SUBUNIT B)		2r3a HISTONE-LYSINE
N-METHYLTRANSFERASE
SUV39H2
(Homo
sapiens)		4 / 6ARG A 181
GLY A 183
GLU A 177
GLU A 180
None
1.17A19.60
20.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K9F_H_LFXH0_1
(DNA TOPOISOMERASE 4
SUBUNIT A
DNA TOPOISOMERASE 4
SUBUNIT B)		3cem GLYCOGEN
PHOSPHORYLASE, LIVER
FORM
(Homo
sapiens)		4 / 6SER A 146
GLY A 809
GLU A 701
GLU A 702
None
1.12A21.00
16.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K9F_H_LFXH0_1
(DNA TOPOISOMERASE 4
SUBUNIT A
DNA TOPOISOMERASE 4
SUBUNIT B)		3ohm 1-PHOSPHATIDYLINOSIT
OL-4,5-BISPHOSPHATE
PHOSPHODIESTERASE
BETA-3
(Homo
sapiens)		4 / 6ARG B 223
SER B 734
GLY B 301
GLU B 303
None
0.96A19.96
15.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K9F_H_LFXH0_1
(DNA TOPOISOMERASE 4
SUBUNIT A
DNA TOPOISOMERASE 4
SUBUNIT B)		4gqb PROTEIN ARGININE
N-METHYLTRANSFERASE
5
(Homo
sapiens)		4 / 6ARG A 368
GLY A 369
GLU A 325
GLU A 328
None
1.08A21.12
17.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K9F_H_LFXH0_1
(DNA TOPOISOMERASE 4
SUBUNIT A
DNA TOPOISOMERASE 4
SUBUNIT B)		4h6y FERM, RHOGEF AND
PLECKSTRIN
DOMAIN-CONTAINING
PROTEIN 1
(Homo
sapiens)		4 / 6ARG A 688
ARG A 698
GLU A1018
GLU A1022
None
1.16A20.63
20.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K9F_H_LFXH0_1
(DNA TOPOISOMERASE 4
SUBUNIT A
DNA TOPOISOMERASE 4
SUBUNIT B)		4hoo LYSINE-SPECIFIC
DEMETHYLASE 4D
(Homo
sapiens)		4 / 6ARG A 243
SER A 308
GLY A 278
GLU A  39
None
0.94A22.22
20.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K9F_H_LFXH0_1
(DNA TOPOISOMERASE 4
SUBUNIT A
DNA TOPOISOMERASE 4
SUBUNIT B)		4k6j WINGS APART-LIKE
PROTEIN HOMOLOG
(Homo
sapiens)		4 / 6SER A 884
GLY A 947
GLU A 993
GLU A 945
None
1.17A21.78
17.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K9F_H_LFXH0_1
(DNA TOPOISOMERASE 4
SUBUNIT A
DNA TOPOISOMERASE 4
SUBUNIT B)		4nen INTEGRIN ALPHA-X
(Homo
sapiens)		4 / 6ARG A 552
GLY A 493
GLU A 528
GLU A 527
None
0.88A18.52
12.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K9F_H_LFXH0_1
(DNA TOPOISOMERASE 4
SUBUNIT A
DNA TOPOISOMERASE 4
SUBUNIT B)		4qj4 1-PHOSPHATIDYLINOSIT
OL 4,5-BISPHOSPHATE
PHOSPHODIESTERASE
BETA-3
(Homo
sapiens)		4 / 6ARG B 223
SER B 734
GLY B 301
GLU B 303
None
1.02A20.38
17.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K9F_H_LFXH0_1
(DNA TOPOISOMERASE 4
SUBUNIT A
DNA TOPOISOMERASE 4
SUBUNIT B)		4z2a FURIN
(Homo
sapiens)		4 / 6SER A 150
ARG A 276
GLY A 277
GLU A 272
None
1.14A21.28
20.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K9F_H_LFXH0_1
(DNA TOPOISOMERASE 4
SUBUNIT A
DNA TOPOISOMERASE 4
SUBUNIT B)		5ikp GLYCOGEN
PHOSPHORYLASE, BRAIN
FORM
(Homo
sapiens)		4 / 6SER A 146
GLY A 809
GLU A 701
GLU A 702
None
0.94A20.98
15.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K9F_H_LFXH0_1
(DNA TOPOISOMERASE 4
SUBUNIT A
DNA TOPOISOMERASE 4
SUBUNIT B)		5nn8 LYSOSOMAL
ALPHA-GLUCOSIDASE
(Homo
sapiens)		4 / 6SER A 599
ARG A 608
GLY A 605
GLU A 196
None
1.04A18.22
15.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RAE_F_LFXF101_1
(DNA TOPOISOMERASE 4
SUBUNIT A
DNA TOPOISOMERASE 4
SUBUNIT B)		1jv1 GLCNAC1P
URIDYLTRANSFERASE
ISOFORM 1: AGX1
(Homo
sapiens)		3 / 4SER A 305
GLY A 222
GLU A 346
None
UD1  A 901 (-3.1A)
None
0.69A21.76
18.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RAE_F_LFXF101_1
(DNA TOPOISOMERASE 4
SUBUNIT A
DNA TOPOISOMERASE 4
SUBUNIT B)		1rrp NUCLEAR PORE COMPLEX
PROTEIN NUP358
(Homo
sapiens)		3 / 4SER B  73
GLY B  33
GLU B  29
None
0.68A13.65
19.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RAE_F_LFXF101_1
(DNA TOPOISOMERASE 4
SUBUNIT A
DNA TOPOISOMERASE 4
SUBUNIT B)		2abj BRANCHED-CHAIN-AMINO
-ACID
AMINOTRANSFERASE,
CYTOSOLIC
(Homo
sapiens)		3 / 4SER A 121
GLY A 286
GLU A 306
None
PLP  A 420 (-3.3A)
None
0.68A20.98
21.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RAE_F_LFXF101_1
(DNA TOPOISOMERASE 4
SUBUNIT A
DNA TOPOISOMERASE 4
SUBUNIT B)		2gk1 BETA-HEXOSAMINIDASE
SUBUNIT ALPHA
(Homo
sapiens)		3 / 4SER I 129
GLY I 250
GLU I 244
None
0.64A21.90
20.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RAE_F_LFXF101_1
(DNA TOPOISOMERASE 4
SUBUNIT A
DNA TOPOISOMERASE 4
SUBUNIT B)		2i99 MU-CRYSTALLIN
HOMOLOG
(Homo
sapiens)		3 / 4SER A 150
GLY A 227
GLU A 257
None
NDP  A 502 (-3.0A)
None
0.62A22.46
22.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RAE_F_LFXF101_1
(DNA TOPOISOMERASE 4
SUBUNIT A
DNA TOPOISOMERASE 4
SUBUNIT B)		2ibu ACETYL-COA
ACETYLTRANSFERASE
(Homo
sapiens)		3 / 4SER A 137
GLY A 391
GLU A 154
None
CSO  A 126 ( 4.5A)
None
0.69A21.74
18.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RAE_F_LFXF101_1
(DNA TOPOISOMERASE 4
SUBUNIT A
DNA TOPOISOMERASE 4
SUBUNIT B)		2nzt HEXOKINASE-2
(Homo
sapiens)		3 / 4SER A 733
GLY A 710
GLU A 494
None
0.69A21.41
14.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RAE_F_LFXF101_1
(DNA TOPOISOMERASE 4
SUBUNIT A
DNA TOPOISOMERASE 4
SUBUNIT B)		2wy3 MHC CLASS I
POLYPEPTIDE-RELATED
SEQUENCE B
UNCHARACTERIZED
PROTEIN UL16
(Homo
sapiens;
Human
betaherpesvirus
5)		3 / 4SER B 127
GLY A 106
GLU A  92
None
0.66A13.96
17.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RAE_F_LFXF101_1
(DNA TOPOISOMERASE 4
SUBUNIT A
DNA TOPOISOMERASE 4
SUBUNIT B)		2xsw 72 KDA INOSITOL
POLYPHOSPHATE
5-PHOSPHATASE
(Homo
sapiens)		3 / 4SER A 582
GLY A 476
GLU A 525
None
0.64A22.82
21.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RAE_F_LFXF101_1
(DNA TOPOISOMERASE 4
SUBUNIT A
DNA TOPOISOMERASE 4
SUBUNIT B)		3e0l GUANINE DEAMINASE
(Homo
sapiens)		3 / 4SER A 150
GLY A 213
GLU A 241
None
0.61A24.30
21.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RAE_F_LFXF101_1
(DNA TOPOISOMERASE 4
SUBUNIT A
DNA TOPOISOMERASE 4
SUBUNIT B)		3kci PROBABLE E3
UBIQUITIN-PROTEIN
LIGASE HERC2
(Homo
sapiens)		3 / 4SER A4087
GLY A4116
GLU A4067
None
0.59A21.06
23.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RAE_H_LFXH101_1
(DNA TOPOISOMERASE 4
SUBUNIT A
DNA TOPOISOMERASE 4
SUBUNIT B)		1cjy PROTEIN (CYTOSOLIC
PHOSPHOLIPASE A2)
(Homo
sapiens)		4 / 5SER A 550
GLY A 355
GLU A 154
GLU A 353
None
1.33A21.90
15.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RAE_H_LFXH101_1
(DNA TOPOISOMERASE 4
SUBUNIT A
DNA TOPOISOMERASE 4
SUBUNIT B)		1mhq ADP-RIBOSYLATION
FACTOR BINDING
PROTEIN GGA2
(Homo
sapiens)		4 / 5SER A 121
GLY A 129
GLU A  87
GLU A 133
None
1.49A15.80
21.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RAE_H_LFXH101_1
(DNA TOPOISOMERASE 4
SUBUNIT A
DNA TOPOISOMERASE 4
SUBUNIT B)		2cp6 RESTIN
(Homo
sapiens)		4 / 5SER A  22
GLY A  35
GLU A  67
GLU A  38
None
1.37A15.05
20.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RAE_H_LFXH101_1
(DNA TOPOISOMERASE 4
SUBUNIT A
DNA TOPOISOMERASE 4
SUBUNIT B)		4fdd TRANSPORTIN-1
(Homo
sapiens)		4 / 5SER A 591
GLY A 692
GLU A 809
GLU A 734
None
1.41A20.89
14.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RAE_H_LFXH101_1
(DNA TOPOISOMERASE 4
SUBUNIT A
DNA TOPOISOMERASE 4
SUBUNIT B)		4k6j WINGS APART-LIKE
PROTEIN HOMOLOG
(Homo
sapiens)		4 / 5SER A 884
GLY A 947
GLU A 993
GLU A 945
None
1.18A21.78
17.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RAE_H_LFXH101_1
(DNA TOPOISOMERASE 4
SUBUNIT A
DNA TOPOISOMERASE 4
SUBUNIT B)		5o2c SERINE/THREONINE-PRO
TEIN KINASE WNK3
(Homo
sapiens)		4 / 5SER A 143
GLY A 164
GLU A 132
GLU A 172
None
1.49A22.74
20.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RAE_H_LFXH101_1
(DNA TOPOISOMERASE 4
SUBUNIT A
DNA TOPOISOMERASE 4
SUBUNIT B)		6ck9 35O22 SCFV HEAVY
CHAIN PORTION
35O22 SCFV LIGHT
CHAIN PORTION
GP41 ECTODOMAIN OF
ENVELOPE
GLYCOPROTEIN GP160
(Homo
sapiens;
Human
immunodeficiency
virus
1)		4 / 5SER B 534
GLY D 100
GLU E  53
GLU E  50
None
MAN  G 884 (-3.7A)
None
None
1.16A10.26
16.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4JUO_F_LFXF101_1
(DNA TOPOISOMERASE 4
SUBUNIT A
DNA TOPOISOMERASE 4
SUBUNIT B
E-SITE DNA)		3e0l GUANINE DEAMINASE
(Homo
sapiens)		3 / 4SER A 150
GLY A 213
GLU A 241
None
0.59A24.30
22.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4JUO_F_LFXF101_1
(DNA TOPOISOMERASE 4
SUBUNIT A
DNA TOPOISOMERASE 4
SUBUNIT B
E-SITE DNA)		4a35 MITOCHONDRIAL
ENOLASE SUPERFAMILY
MEMBER 1
(Homo
sapiens)		3 / 4SER A 338
GLY A  55
GLU A 424
None
0.57A21.48
21.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4JUO_F_LFXF101_1
(DNA TOPOISOMERASE 4
SUBUNIT A
DNA TOPOISOMERASE 4
SUBUNIT B
E-SITE DNA)		4ayx ATP-BINDING CASSETTE
SUB-FAMILY B MEMBER
10
(Homo
sapiens)		3 / 4SER A 449
GLY A 333
GLU A 391
None
0.46A22.50
22.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4JUO_F_LFXF101_1
(DNA TOPOISOMERASE 4
SUBUNIT A
DNA TOPOISOMERASE 4
SUBUNIT B
E-SITE DNA)		4bb9 GLUCOKINASE
REGULATORY PROTEIN
(Homo
sapiens)		3 / 4SER A 490
GLY A 263
GLU A 271
None
0.50A21.60
21.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4JUO_F_LFXF101_1
(DNA TOPOISOMERASE 4
SUBUNIT A
DNA TOPOISOMERASE 4
SUBUNIT B
E-SITE DNA)		4f9o HEXOKINASE-1
(Homo
sapiens)		3 / 4SER A 733
GLY A 710
GLU A 494
None
0.60A19.78
23.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4JUO_F_LFXF101_1
(DNA TOPOISOMERASE 4
SUBUNIT A
DNA TOPOISOMERASE 4
SUBUNIT B
E-SITE DNA)		4fys AMINOPEPTIDASE N
(Homo
sapiens)		3 / 4SER A 469
GLY A 192
GLU A 185
None
0.54A19.45
22.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4JUO_F_LFXF101_1
(DNA TOPOISOMERASE 4
SUBUNIT A
DNA TOPOISOMERASE 4
SUBUNIT B
E-SITE DNA)		5v7i SERINE
HYDROXYMETHYLTRANSFE
RASE, MITOCHONDRIAL
(Homo
sapiens)		3 / 4SER A 417
GLY A 175
GLU A 191
None
0.62A23.36
21.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4JUO_F_LFXF101_1
(DNA TOPOISOMERASE 4
SUBUNIT A
DNA TOPOISOMERASE 4
SUBUNIT B
E-SITE DNA)		5v9p LYSINE-SPECIFIC
DEMETHYLASE 5A
(Homo
sapiens)		3 / 4SER A 420
GLY A 442
GLU A 452
None
0.60A20.10
22.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4JUO_F_LFXF101_1
(DNA TOPOISOMERASE 4
SUBUNIT A
DNA TOPOISOMERASE 4
SUBUNIT B
E-SITE DNA)		5xtc NADH DEHYDROGENASE
[UBIQUINONE] 1
SUBUNIT C2
(Homo
sapiens)		3 / 4SER g  40
GLY g  71
GLU g  78
None
0.56A12.90
9.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4JUO_F_LFXF101_1
(DNA TOPOISOMERASE 4
SUBUNIT A
DNA TOPOISOMERASE 4
SUBUNIT B
E-SITE DNA)		6bsz METABOTROPIC
GLUTAMATE RECEPTOR 8
(Homo
sapiens)		3 / 4SER A 308
GLY A 225
GLU A 256
None
0.57A10.16
8.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z2D_F_LFXF102_1
(DNA GYRASE SUBUNIT A
DNA GYRASE SUBUNIT B
SYMMETRIZED E-SITE
DNA)		1t5i C_TERMINAL DOMAIN OF
A PROBABLE
ATP-DEPENDENT RNA
HELICASE
(Homo
sapiens)		3 / 4ARG A 377
GLY A 379
GLU A 354
None
0.68A16.39
23.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z2D_F_LFXF102_1
(DNA GYRASE SUBUNIT A
DNA GYRASE SUBUNIT B
SYMMETRIZED E-SITE
DNA)		1x9d ENDOPLASMIC
RETICULUM
MANNOSYL-OLIGOSACCHA
RIDE
1,2-ALPHA-MANNOSIDAS
E
(Homo
sapiens)		3 / 4ARG A 495
GLY A 493
GLU A 492
None
0.56A22.46
20.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z2D_F_LFXF102_1
(DNA GYRASE SUBUNIT A
DNA GYRASE SUBUNIT B
SYMMETRIZED E-SITE
DNA)		2buj SERINE/THREONINE-PRO
TEIN KINASE 16
(Homo
sapiens)		3 / 4ARG A 134
GLY A 135
GLU A 137
None
0.60A20.88
22.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z2D_F_LFXF102_1
(DNA GYRASE SUBUNIT A
DNA GYRASE SUBUNIT B
SYMMETRIZED E-SITE
DNA)		2c0l PEROXISOMAL
TARGETING SIGNAL 1
RECEPTOR
(Homo
sapiens)		3 / 4ARG A 345
GLY A 349
GLU A 348
None
0.60A22.05
22.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z2D_F_LFXF102_1
(DNA GYRASE SUBUNIT A
DNA GYRASE SUBUNIT B
SYMMETRIZED E-SITE
DNA)		2e8m EPIDERMAL GROWTH
FACTOR RECEPTOR
KINASE SUBSTRATE 8
(Homo
sapiens)		3 / 4ARG A  81
GLY A  79
GLU A  78
None
0.61A14.65
18.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z2D_F_LFXF102_1
(DNA GYRASE SUBUNIT A
DNA GYRASE SUBUNIT B
SYMMETRIZED E-SITE
DNA)		2lw7 HISTIDINE--TRNA
LIGASE, CYTOPLASMIC
(Homo
sapiens)		3 / 4ARG A  16
GLY A  14
GLU A  33
None
0.66A16.80
20.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z2D_F_LFXF102_1
(DNA GYRASE SUBUNIT A
DNA GYRASE SUBUNIT B
SYMMETRIZED E-SITE
DNA)		2pyf T-CELL RECEPTOR,
BETA CHAIN
(Homo
sapiens)		3 / 4ARG B 239
GLY B 238
GLU B 126
None
0.64A19.96
21.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z2D_F_LFXF102_1
(DNA GYRASE SUBUNIT A
DNA GYRASE SUBUNIT B
SYMMETRIZED E-SITE
DNA)		2r3a HISTONE-LYSINE
N-METHYLTRANSFERASE
SUV39H2
(Homo
sapiens)		3 / 4ARG A 181
GLY A 183
GLU A 180
None
0.63A19.76
20.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z2D_F_LFXF102_1
(DNA GYRASE SUBUNIT A
DNA GYRASE SUBUNIT B
SYMMETRIZED E-SITE
DNA)		3c6m SPERMINE SYNTHASE
(Homo
sapiens)		3 / 4ARG A 268
GLY A 267
GLU A 266
None
0.59A22.05
24.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z2D_F_LFXF102_1
(DNA GYRASE SUBUNIT A
DNA GYRASE SUBUNIT B
SYMMETRIZED E-SITE
DNA)		4m4z SRC-LIKE-ADAPTER 2
(Homo
sapiens)		3 / 4ARG A  54
GLY A  56
GLU A  57
None
0.52A16.38
21.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z2D_F_LFXF102_1
(DNA GYRASE SUBUNIT A
DNA GYRASE SUBUNIT B
SYMMETRIZED E-SITE
DNA)		5ei0 SERPIN A12
(Homo
sapiens)		3 / 4ARG A 363
GLY A 364
GLU A 217
None
0.47A21.75
23.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z2D_F_LFXF102_1
(DNA GYRASE SUBUNIT A
DNA GYRASE SUBUNIT B
SYMMETRIZED E-SITE
DNA)		5eqx DESMOGLEIN-3
(Homo
sapiens)		3 / 4ARG A  10
GLY A  12
GLU A  13
None
0.58A22.84
18.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z2D_F_LFXF102_1
(DNA GYRASE SUBUNIT A
DNA GYRASE SUBUNIT B
SYMMETRIZED E-SITE
DNA)		5hcc COMPLEMENT C5
(Homo
sapiens)		3 / 4ARG B  32
GLY B  34
GLU B  37
None
0.58A21.44
16.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z2D_F_LFXF102_1
(DNA GYRASE SUBUNIT A
DNA GYRASE SUBUNIT B
SYMMETRIZED E-SITE
DNA)		5i4e MYOSIN-14,ALPHA-ACTI
NIN A
(Dictyostelium
discoideum;
Homo
sapiens)		3 / 4ARG A 225
GLY A 232
GLU A 235
None
0.64A20.06
15.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z2D_F_LFXF102_1
(DNA GYRASE SUBUNIT A
DNA GYRASE SUBUNIT B
SYMMETRIZED E-SITE
DNA)		5k1b WD REPEAT-CONTAINING
PROTEIN 48
(Homo
sapiens)		3 / 4ARG B 523
GLY B 522
GLU B 519
None
0.67A21.13
16.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z2D_F_LFXF102_1
(DNA GYRASE SUBUNIT A
DNA GYRASE SUBUNIT B
SYMMETRIZED E-SITE
DNA)		5kij ENDOPLASMIC
RETICULUM
MANNOSYL-OLIGOSACCHA
RIDE
1,2-ALPHA-MANNOSIDAS
E
(Homo
sapiens)		3 / 4ARG A 495
GLY A 493
GLU A 492
None
0.57A21.42
21.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z2D_F_LFXF102_1
(DNA GYRASE SUBUNIT A
DNA GYRASE SUBUNIT B
SYMMETRIZED E-SITE
DNA)		5njj PROTEIN NUMB HOMOLOG
(Homo
sapiens)		3 / 4ARG A  33
GLY A  31
GLU A  30
None
0.63A10.85
17.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5BTG_E_LFXE101_1
(DNA GYRASE SUBUNIT A
DNA GYRASE SUBUNIT B
DNA SUBSTRATE 24-MER
GGTCATGAATGACTATGCAC
GTAA)		2atv RAS-LIKE
ESTROGEN-REGULATED
GROWTH INHIBITOR
(Homo
sapiens)		4 / 6ALA A 149
ARG A  14
GLY A  13
GLU A  94
GDP  A 415 (-3.7A)
None
None
None
0.88A17.43
24.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5BTG_E_LFXE101_1
(DNA GYRASE SUBUNIT A
DNA GYRASE SUBUNIT B
DNA SUBSTRATE 24-MER
GGTCATGAATGACTATGCAC
GTAA)		3bdl STAPHYLOCOCCAL
NUCLEASE
DOMAIN-CONTAINING
PROTEIN 1
(Homo
sapiens)		4 / 6ALA A 713
ARG A 707
GLY A 708
GLU A 550
None
0.87A22.04
21.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5BTG_E_LFXE101_1
(DNA GYRASE SUBUNIT A
DNA GYRASE SUBUNIT B
DNA SUBSTRATE 24-MER
GGTCATGAATGACTATGCAC
GTAA)		3evi PHOSDUCIN-LIKE
PROTEIN 2
(Homo
sapiens)		4 / 6ALA A 201
ARG A 137
GLY A  90
GLU A  91
None
0.95A14.25
16.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5BTG_E_LFXE101_1
(DNA GYRASE SUBUNIT A
DNA GYRASE SUBUNIT B
DNA SUBSTRATE 24-MER
GGTCATGAATGACTATGCAC
GTAA)		3rc3 ATP-DEPENDENT RNA
HELICASE SUPV3L1,
MITOCHONDRIAL
(Homo
sapiens)		4 / 6ALA A 217
ARG A 200
THR A 336
GLU A 338
None
0.87A22.36
16.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5BTG_E_LFXE101_1
(DNA GYRASE SUBUNIT A
DNA GYRASE SUBUNIT B
DNA SUBSTRATE 24-MER
GGTCATGAATGACTATGCAC
GTAA)		4f92 U5 SMALL NUCLEAR
RIBONUCLEOPROTEIN
200 KDA HELICASE
(Homo
sapiens)		4 / 6ALA B1079
ARG B 624
THR B 589
GLU B 591
None
0.96A15.04
10.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5BTG_E_LFXE101_1
(DNA GYRASE SUBUNIT A
DNA GYRASE SUBUNIT B
DNA SUBSTRATE 24-MER
GGTCATGAATGACTATGCAC
GTAA)		4wfs TRNA-DIHYDROURIDINE(
20) SYNTHASE
[NAD(P)+]-LIKE
(Homo
sapiens)		4 / 6ALA A 181
ARG A  28
THR A  76
GLU A  80
None
0.97A21.24
23.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5BTG_E_LFXE101_1
(DNA GYRASE SUBUNIT A
DNA GYRASE SUBUNIT B
DNA SUBSTRATE 24-MER
GGTCATGAATGACTATGCAC
GTAA)		5hvf CARBOXYPEPTIDASE B2
(Homo
sapiens)		4 / 6ARG A 302
GLY A 336
GLU A 338
ARG A 235
None
None
None
FLC  A 509 (-2.8A)
0.85A19.77
19.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5BTG_E_LFXE101_1
(DNA GYRASE SUBUNIT A
DNA GYRASE SUBUNIT B
DNA SUBSTRATE 24-MER
GGTCATGAATGACTATGCAC
GTAA)		5nst HEAVY CHAIN OF
ANTIBODY MGD21
(Homo
sapiens)		4 / 6ARG B 134
GLY B 135
THR B 161
GLU B 165
GOL  B 402 (-3.4A)
None
None
None
0.79A20.98
20.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5BTG_E_LFXE101_1
(DNA GYRASE SUBUNIT A
DNA GYRASE SUBUNIT B
DNA SUBSTRATE 24-MER
GGTCATGAATGACTATGCAC
GTAA)		6bwv TUMOR NECROSIS
FACTOR LIGAND
SUPERFAMILY MEMBER 9
(Homo
sapiens)		4 / 6ALA A 192
ARG A 221
GLY A 159
ARG A 151
None
0.70A11.45
17.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5BTG_F_LFXF101_1
(DNA GYRASE SUBUNIT A
DNA GYRASE SUBUNIT B
DNA SUBSTRATE 24-MER
TTACGTGCATAGTCATTCAT
GACC)		1he3 BILIVERDIN IX BETA
REDUCTASE
(Homo
sapiens)		4 / 7ALA A   7
ASP A  54
GLY A  90
THR A  84
None
NAP  A1206 (-3.2A)
None
None
0.91A19.33
21.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5BTG_F_LFXF101_1
(DNA GYRASE SUBUNIT A
DNA GYRASE SUBUNIT B
DNA SUBSTRATE 24-MER
TTACGTGCATAGTCATTCAT
GACC)		2o2k METHIONINE SYNTHASE
(Homo
sapiens)		4 / 7ALA A 935
ASP A1043
THR A1184
GLU A1185
None
0.85A21.26
22.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5BTG_F_LFXF101_1
(DNA GYRASE SUBUNIT A
DNA GYRASE SUBUNIT B
DNA SUBSTRATE 24-MER
TTACGTGCATAGTCATTCAT
GACC)		2w0p FILAMIN-A
(Homo
sapiens)		4 / 7ALA A2266
ASP A2290
ARG A2288
GLU A2286
None
0.78A12.02
14.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5BTG_F_LFXF101_1
(DNA GYRASE SUBUNIT A
DNA GYRASE SUBUNIT B
DNA SUBSTRATE 24-MER
TTACGTGCATAGTCATTCAT
GACC)		3bdl STAPHYLOCOCCAL
NUCLEASE
DOMAIN-CONTAINING
PROTEIN 1
(Homo
sapiens)		4 / 7ALA A 713
ARG A 707
GLY A 708
GLU A 550
None
0.90A22.04
21.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5BTG_F_LFXF101_1
(DNA GYRASE SUBUNIT A
DNA GYRASE SUBUNIT B
DNA SUBSTRATE 24-MER
TTACGTGCATAGTCATTCAT
GACC)		3na0 CHOLESTEROL
SIDE-CHAIN CLEAVAGE
ENZYME,
MITOCHONDRIAL
(Homo
sapiens)		4 / 7ALA A 173
ASP A 297
ARG A 299
GLY A 300
None
0.51A22.28
21.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5BTG_F_LFXF101_1
(DNA GYRASE SUBUNIT A
DNA GYRASE SUBUNIT B
DNA SUBSTRATE 24-MER
TTACGTGCATAGTCATTCAT
GACC)		3nzu PHOSPHATIDYLINOSITOL
-4,5-BISPHOSPHATE
3-KINASE CATALYTIC
SUBUNIT GAMMA
ISOFORM
(Homo
sapiens)		4 / 7ASP A 653
ARG A 687
GLY A 685
GLU A 187
None
0.93A19.26
13.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5BTG_F_LFXF101_1
(DNA GYRASE SUBUNIT A
DNA GYRASE SUBUNIT B
DNA SUBSTRATE 24-MER
TTACGTGCATAGTCATTCAT
GACC)		3qxm GLUTAMATE RECEPTOR
IONOTROPIC, KAINATE
2
(Homo
sapiens)		4 / 7ARG A 450
ASP A 476
ARG A 472
GLY A 469
None
0.86A22.01
25.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5BTG_F_LFXF101_1
(DNA GYRASE SUBUNIT A
DNA GYRASE SUBUNIT B
DNA SUBSTRATE 24-MER
TTACGTGCATAGTCATTCAT
GACC)		3rc3 ATP-DEPENDENT RNA
HELICASE SUPV3L1,
MITOCHONDRIAL
(Homo
sapiens)		4 / 7ALA A 217
ARG A 200
THR A 336
GLU A 338
None
0.80A22.36
16.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5BTG_F_LFXF101_1
(DNA GYRASE SUBUNIT A
DNA GYRASE SUBUNIT B
DNA SUBSTRATE 24-MER
TTACGTGCATAGTCATTCAT
GACC)		4c2x GLYCYLPEPTIDE
N-TETRADECANOYLTRANS
FERASE 2
(Homo
sapiens)		4 / 7ALA A 438
ARG A 339
GLY A 337
GLU A 388
None
0.93A24.23
22.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5BTG_F_LFXF101_1
(DNA GYRASE SUBUNIT A
DNA GYRASE SUBUNIT B
DNA SUBSTRATE 24-MER
TTACGTGCATAGTCATTCAT
GACC)		4p3w FILAMIN-A
(Homo
sapiens)		4 / 7ALA A2266
ASP A2290
ARG A2288
GLU A2286
None
0.73A15.51
23.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5BTG_F_LFXF101_1
(DNA GYRASE SUBUNIT A
DNA GYRASE SUBUNIT B
DNA SUBSTRATE 24-MER
TTACGTGCATAGTCATTCAT
GACC)		4r3z ARGININE--TRNA
LIGASE, CYTOPLASMIC
(Homo
sapiens)		4 / 7ALA B 531
ARG B 472
GLY B 469
GLU B 468
None
0.92A23.55
18.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5BTG_F_LFXF101_1
(DNA GYRASE SUBUNIT A
DNA GYRASE SUBUNIT B
DNA SUBSTRATE 24-MER
TTACGTGCATAGTCATTCAT
GACC)		4r3z ARGININE--TRNA
LIGASE, CYTOPLASMIC
(Homo
sapiens)		4 / 7ALA B 532
ASP B 475
GLY B 469
GLU B 468
None
0.91A23.55
18.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5BTG_F_LFXF101_1
(DNA GYRASE SUBUNIT A
DNA GYRASE SUBUNIT B
DNA SUBSTRATE 24-MER
TTACGTGCATAGTCATTCAT
GACC)		5dis MALTOSE-BINDING
PERIPLASMIC
PROTEIN,NUCLEAR PORE
COMPLEX PROTEIN
NUP214
(Escherichia
coli;
Homo
sapiens)		4 / 7ALA D 213
ASP D  14
GLY D 228
GLU D 111
None
0.90A21.10
20.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5BTI_E_LFXE101_1
(DNA GYRASE SUBUNIT A
DNA GYRASE SUBUNIT B
DNA SUBSTRATE 24-MER
GGTCATGAATGACTATGCAC
GTAA)		2a2d N-ACETYLGALACTOSAMIN
E KINASE
(Homo
sapiens)		4 / 5SER A 146
ARG A 180
GLY A 183
GLU A 185
ANP  A 461 (-2.7A)
None
None
None
1.19A22.48
19.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5BTI_E_LFXE101_1
(DNA GYRASE SUBUNIT A
DNA GYRASE SUBUNIT B
DNA SUBSTRATE 24-MER
GGTCATGAATGACTATGCAC
GTAA)		2eo1 CDNA FLJ14124 FIS,
CLONE MAMMA1002498
(Homo
sapiens)		4 / 5SER A   5
GLY A  87
THR A  43
GLU A  84
None
1.15A10.74
19.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5BTI_E_LFXE101_1
(DNA GYRASE SUBUNIT A
DNA GYRASE SUBUNIT B
DNA SUBSTRATE 24-MER
GGTCATGAATGACTATGCAC
GTAA)		2j6l ALDEHYDE
DEHYDROGENASE FAMILY
7 MEMBER A1
(Homo
sapiens)		4 / 5SER A 431
GLY A 471
THR A 246
GLU A 269
None
None
NAI  A1501 (-4.2A)
NAI  A1501 (-4.0A)
0.99A22.97
19.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5BTI_E_LFXE101_1
(DNA GYRASE SUBUNIT A
DNA GYRASE SUBUNIT B
DNA SUBSTRATE 24-MER
GGTCATGAATGACTATGCAC
GTAA)		2lgw DNAJ HOMOLOG
SUBFAMILY B MEMBER 2
(Homo
sapiens)		4 / 5SER A   3
ARG A  67
GLY A  69
GLU A  71
None
1.00A9.70
17.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5BTI_E_LFXE101_1
(DNA GYRASE SUBUNIT A
DNA GYRASE SUBUNIT B
DNA SUBSTRATE 24-MER
GGTCATGAATGACTATGCAC
GTAA)		3bg9 PYRUVATE
CARBOXYLASE,
MITOCHONDRIAL
(Homo
sapiens)		5 / 5SER A 910
ARG A 675
GLY A 609
THR A 568
GLU A 605
None
1.36A22.34
17.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5BTI_E_LFXE101_1
(DNA GYRASE SUBUNIT A
DNA GYRASE SUBUNIT B
DNA SUBSTRATE 24-MER
GGTCATGAATGACTATGCAC
GTAA)		3dwb ENDOTHELIN-CONVERTIN
G ENZYME 1
(Homo
sapiens)		4 / 5SER A 127
ARG A 738
GLY A 741
THR A 664
None
RDF  A 817 (-3.0A)
None
None
1.06A19.82
16.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5BTI_E_LFXE101_1
(DNA GYRASE SUBUNIT A
DNA GYRASE SUBUNIT B
DNA SUBSTRATE 24-MER
GGTCATGAATGACTATGCAC
GTAA)		3hy8 PYRIDOXINE-5'-PHOSPH
ATE OXIDASE
(Homo
sapiens)		4 / 5ARG A 116
GLY A 118
THR A  87
GLU A 120
PO4  A 370 ( 3.7A)
None
None
None
1.08A19.96
19.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5BTI_E_LFXE101_1
(DNA GYRASE SUBUNIT A
DNA GYRASE SUBUNIT B
DNA SUBSTRATE 24-MER
GGTCATGAATGACTATGCAC
GTAA)		3zyx AMINE OXIDASE
[FLAVIN-CONTAINING]
B
(Homo
sapiens)		4 / 5SER A  26
ARG A  67
GLY A 443
THR A 430
None
1.14A22.90
20.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5BTI_E_LFXE101_1
(DNA GYRASE SUBUNIT A
DNA GYRASE SUBUNIT B
DNA SUBSTRATE 24-MER
GGTCATGAATGACTATGCAC
GTAA)		4obs ALPHA-L-IDURONIDASE
(Homo
sapiens)		4 / 5ARG A 210
GLY A 208
THR A 249
GLU A 207
None
1.09A22.13
19.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5BTI_E_LFXE101_1
(DNA GYRASE SUBUNIT A
DNA GYRASE SUBUNIT B
DNA SUBSTRATE 24-MER
GGTCATGAATGACTATGCAC
GTAA)		5j5j DESMOCOLLIN-2,DESMOG
LEIN-2
(Homo
sapiens)		4 / 5ARG A 241
GLY A 281
THR A 278
GLU A 280
None
1.19A22.31
18.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5BTI_E_LFXE101_1
(DNA GYRASE SUBUNIT A
DNA GYRASE SUBUNIT B
DNA SUBSTRATE 24-MER
GGTCATGAATGACTATGCAC
GTAA)		5yz0 SERINE/THREONINE-PRO
TEIN KINASE ATR
(Homo
sapiens)		4 / 5ARG A2008
GLY A2007
THR A1989
GLU A1986
None
1.11A11.76
16.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5BTI_F_LFXF101_1
(DNA GYRASE SUBUNIT A
DNA GYRASE SUBUNIT B
DNA SUBSTRATE 24-MER
TTACGTGCATAGTCATTCAT
GACC)		1q20 SULFOTRANSFERASE
FAMILY, CYTOSOLIC,
2B, MEMBER 1 ISOFORM
B
(Homo
sapiens)		4 / 5SER A 123
ARG A 147
GLY A 146
GLU A 211
None
A3P  A 314 (-3.0A)
None
None
1.00A20.24
20.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5BTI_F_LFXF101_1
(DNA GYRASE SUBUNIT A
DNA GYRASE SUBUNIT B
DNA SUBSTRATE 24-MER
TTACGTGCATAGTCATTCAT
GACC)		2eo1 CDNA FLJ14124 FIS,
CLONE MAMMA1002498
(Homo
sapiens)		4 / 5SER A   5
GLY A  87
THR A  43
GLU A  84
None
1.13A10.74
19.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5BTI_F_LFXF101_1
(DNA GYRASE SUBUNIT A
DNA GYRASE SUBUNIT B
DNA SUBSTRATE 24-MER
TTACGTGCATAGTCATTCAT
GACC)		2j6l ALDEHYDE
DEHYDROGENASE FAMILY
7 MEMBER A1
(Homo
sapiens)		4 / 5SER A 431
GLY A 471
THR A 246
GLU A 269
None
None
NAI  A1501 (-4.2A)
NAI  A1501 (-4.0A)
0.98A22.97
19.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5BTI_F_LFXF101_1
(DNA GYRASE SUBUNIT A
DNA GYRASE SUBUNIT B
DNA SUBSTRATE 24-MER
TTACGTGCATAGTCATTCAT
GACC)		3bg9 PYRUVATE
CARBOXYLASE,
MITOCHONDRIAL
(Homo
sapiens)		4 / 5SER A 910
ARG A 675
THR A 568
GLU A 605
None
1.15A22.34
17.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5BTI_F_LFXF101_1
(DNA GYRASE SUBUNIT A
DNA GYRASE SUBUNIT B
DNA SUBSTRATE 24-MER
TTACGTGCATAGTCATTCAT
GACC)		3exh PYRUVATE
DEHYDROGENASE E1
COMPONENT SUBUNIT
BETA, MITOCHONDRIAL
(Homo
sapiens)		4 / 5SER B 252
ARG B 278
GLY B 282
GLU B 281
None
1.13A21.14
22.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5BTI_F_LFXF101_1
(DNA GYRASE SUBUNIT A
DNA GYRASE SUBUNIT B
DNA SUBSTRATE 24-MER
TTACGTGCATAGTCATTCAT
GACC)		3hy8 PYRIDOXINE-5'-PHOSPH
ATE OXIDASE
(Homo
sapiens)		4 / 5ARG A 116
GLY A 118
THR A  87
GLU A 120
PO4  A 370 ( 3.7A)
None
None
None
1.10A19.96
19.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5BTI_F_LFXF101_1
(DNA GYRASE SUBUNIT A
DNA GYRASE SUBUNIT B
DNA SUBSTRATE 24-MER
TTACGTGCATAGTCATTCAT
GACC)		3zyx AMINE OXIDASE
[FLAVIN-CONTAINING]
B
(Homo
sapiens)		4 / 5SER A  26
ARG A  67
GLY A 443
THR A 430
None
1.08A22.90
20.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5BTI_F_LFXF101_1
(DNA GYRASE SUBUNIT A
DNA GYRASE SUBUNIT B
DNA SUBSTRATE 24-MER
TTACGTGCATAGTCATTCAT
GACC)		5dis MALTOSE-BINDING
PERIPLASMIC
PROTEIN,NUCLEAR PORE
COMPLEX PROTEIN
NUP214
(Escherichia
coli;
Homo
sapiens)		4 / 5SER D 238
ARG D 316
GLY D 243
THR D 320
None
1.15A21.06
20.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5BTI_F_LFXF101_1
(DNA GYRASE SUBUNIT A
DNA GYRASE SUBUNIT B
DNA SUBSTRATE 24-MER
TTACGTGCATAGTCATTCAT
GACC)		5nst HEAVY CHAIN OF
ANTIBODY MGD21
(Homo
sapiens)		4 / 5ARG B 134
GLY B 135
THR B 161
GLU B 165
GOL  B 402 (-3.4A)
None
None
None
0.86A20.98
20.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5BTI_F_LFXF101_1
(DNA GYRASE SUBUNIT A
DNA GYRASE SUBUNIT B
DNA SUBSTRATE 24-MER
TTACGTGCATAGTCATTCAT
GACC)		5v57 SMOOTHENED
HOMOLOG,FLAVODOXIN,S
MOOTHENED HOMOLOG
(Desulfovibrio
vulgaris;
Homo
sapiens)		4 / 5ARG A 302
GLY A 383
THR A 307
GLU A 305
None
1.12A22.40
18.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5BTI_F_LFXF101_1
(DNA GYRASE SUBUNIT A
DNA GYRASE SUBUNIT B
DNA SUBSTRATE 24-MER
TTACGTGCATAGTCATTCAT
GACC)		5yz0 SERINE/THREONINE-PRO
TEIN KINASE ATR
(Homo
sapiens)		4 / 5ARG A2008
GLY A2007
THR A1989
GLU A1986
None
1.07A11.76
16.06