POTENTIAL TARGETS FROM HUMAN (RESULTS FROM SUB-STRUCTURAL SIMILARITY SEARCHES)
1) User may click on the DrReposER ID (the second column) to get information on the binding sites and drug molecule.
2) Click View (the second last column) to view matched residues and superposition in the NGL viewer (upper right part).
3) User may also click on the Dock (the last column) to get script for molecular docking in UCSF Chimera through AutoDock Vina.


DrReposER ID / Desc. Hit
PDBID
Hit
Macromolecule
Res.
Matches
Interface HETATM RMSD Seq.
Identity (%)
View Dock
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3WZD_A_LEVA1201_1
(VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 2)
1rjb FL CYTOKINE RECEPTOR
(Homo
sapiens)
7 / 12LEU A 616
GLY A 617
VAL A 624
ALA A 642
GLU A 661
CYH A 694
CYH A 828
None
0.87A48.27
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3WZD_A_LEVA1201_1
(VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 2)
1rjb FL CYTOKINE RECEPTOR
(Homo
sapiens)
7 / 12LEU A 616
VAL A 624
ALA A 642
GLU A 661
CYH A 694
GLY A 697
CYH A 828
None
0.58A48.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WZD_A_LEVA1201_1
(VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 2)
1s9i DUAL SPECIFICITY
MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE 2
(Homo
sapiens)
6 / 12LEU A  78
VAL A  86
ALA A  99
GLY A 153
CYH A 211
PHE A 213
ATP  A 535 (-3.9A)
ATP  A 535 (-4.1A)
ATP  A 535 (-3.6A)
ATP  A 535 ( 4.7A)
ATP  A 535 ( 4.5A)
5EA  A1001 (-3.6A)
0.67A24.86
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3WZD_A_LEVA1201_1
(VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 2)
1t46 HOMO SAPIENS V-KIT
HARDY-ZUCKERMAN 4
FELINE SARCOMA VIRAL
ONCOGENE HOMOLOG
(Homo
sapiens)
8 / 12LEU A 595
VAL A 603
ALA A 621
GLU A 640
LEU A 644
CYH A 673
GLY A 676
CYH A 809
STI  A   3 ( 3.8A)
STI  A   3 ( 4.6A)
STI  A   3 (-3.5A)
STI  A   3 (-3.6A)
STI  A   3 (-4.4A)
STI  A   3 (-4.5A)
STI  A   3 ( 3.8A)
STI  A   3 (-4.5A)
0.51A53.80
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3WZD_A_LEVA1201_1
(VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 2)
1u59 TYROSINE-PROTEIN
KINASE ZAP-70
(Homo
sapiens)
5 / 12LEU A 344
VAL A 352
ALA A 367
GLU A 386
GLY A 420
STU  A 100 (-3.8A)
STU  A 100 (-4.8A)
STU  A 100 (-3.2A)
None
STU  A 100 (-3.5A)
0.54A33.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WZD_A_LEVA1201_1
(VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 2)
1zlt SERINE/THREONINE-PRO
TEIN KINASE CHK1
(Homo
sapiens)
6 / 12LEU A  15
VAL A  23
ALA A  36
GLU A  55
CYH A  87
GLY A  90
HYM  A 400 (-4.2A)
HYM  A 400 (-4.3A)
HYM  A 400 (-3.5A)
None
HYM  A 400 (-4.2A)
None
0.59A26.10
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3WZD_A_LEVA1201_1
(VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 2)
2dq7 PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE FYN
(Homo
sapiens)
5 / 12LEU X  17
VAL X  25
ALA X  37
GLU X  54
GLY X  88
STU  X 902 (-3.8A)
STU  X 902 ( 4.8A)
STU  X 902 (-3.1A)
STU  X 902 ( 4.4A)
STU  X 902 (-3.5A)
0.45A35.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WZD_A_LEVA1201_1
(VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 2)
2hw6 MAP
KINASE-INTERACTING
SERINE/THREONINE-PRO
TEIN KINASE 1
(Homo
sapiens)
6 / 12LEU A  55
VAL A  63
ALA A  76
GLY A 130
CYH A 190
PHE A 230
None
0.94A26.21
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3WZD_A_LEVA1201_1
(VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 2)
2hz0 PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1
(Homo
sapiens)
5 / 12LEU A 248
VAL A 256
ALA A 269
GLU A 286
GLY A 321
GIN  A 600 ( 4.6A)
GIN  A 600 ( 4.7A)
GIN  A 600 (-3.1A)
GIN  A 600 (-3.6A)
None
0.39A38.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WZD_A_LEVA1201_1
(VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 2)
2iwi SERINE/THREONINE-PRO
TEIN KINASE PIM-2
(Homo
sapiens)
6 / 12LEU A  38
GLY A  39
VAL A  46
ALA A  59
GLU A  83
LEU A  87
HB1  A1289 ( 4.1A)
HB1  A1289 (-3.1A)
HB1  A1289 (-3.6A)
HB1  A1289 ( 3.7A)
None
None
0.87A23.99
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3WZD_A_LEVA1201_1
(VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 2)
2ogv MACROPHAGE
COLONY-STIMULATING
FACTOR 1 RECEPTOR
PRECURSOR
(Homo
sapiens)
6 / 12LEU A 588
VAL A 596
ALA A 614
GLU A 633
CYH A 666
GLY A 669
None
0.58A50.60
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3WZD_A_LEVA1201_1
(VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 2)
2psq FIBROBLAST GROWTH
FACTOR RECEPTOR 2
(Homo
sapiens)
7 / 12LEU A 487
GLY A 488
VAL A 495
ALA A 515
GLU A 534
VAL A 564
GLY A 570
None
0.46A48.06
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3WZD_A_LEVA1201_1
(VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 2)
2r4b RECEPTOR
TYROSINE-PROTEIN
KINASE ERBB-4
(Homo
sapiens)
5 / 12LEU A 724
VAL A 732
ALA A 749
GLY A 802
PHE A 862
GW7  A   1 ( 4.2A)
GW7  A   1 ( 4.8A)
GW7  A   1 (-3.3A)
GW7  A   1 (-3.6A)
GW7  A   1 (-3.8A)
0.50A33.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WZD_A_LEVA1201_1
(VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 2)
2xik SERINE/THREONINE
PROTEIN KINASE 25
(Homo
sapiens)
5 / 12VAL A  34
ALA A  47
GLU A  66
LEU A  70
GLY A 101
J60  A1294 ( 4.9A)
J60  A1294 (-3.3A)
None
None
J60  A1294 ( 3.8A)
0.50A26.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WZD_A_LEVA1201_1
(VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 2)
2z2w WEE1-LIKE PROTEIN
KINASE
(Homo
sapiens)
5 / 12VAL A 313
ALA A 326
GLU A 346
CYH A 379
GLY A 382
770  A 901 ( 4.7A)
770  A 901 (-3.5A)
770  A 901 (-3.9A)
770  A 901 (-3.9A)
770  A 901 (-3.4A)
0.49A27.05
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3WZD_A_LEVA1201_1
(VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 2)
2z8c INSULIN RECEPTOR
(Homo
sapiens)
5 / 12LEU A1002
VAL A1010
ALA A1028
GLU A1047
GLY A1082
S91  A   1 ( 4.1A)
S91  A   1 ( 4.9A)
S91  A   1 (-3.2A)
None
S91  A   1 (-3.3A)
0.52A36.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WZD_A_LEVA1201_1
(VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 2)
3a62 RIBOSOMAL PROTEIN S6
KINASE BETA-1
(Homo
sapiens)
6 / 12LEU A  97
VAL A 105
ALA A 121
GLU A 143
LEU A 147
GLY A 178
STU  A 400 (-3.8A)
STU  A 400 (-4.9A)
STU  A 400 (-3.1A)
STU  A 400 ( 4.3A)
None
STU  A 400 ( 4.4A)
0.52A26.74
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3WZD_A_LEVA1201_1
(VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 2)
3b2t FIBROBLAST GROWTH
FACTOR RECEPTOR 2
(Homo
sapiens)
6 / 12LEU A 487
GLY A 488
VAL A 495
ALA A 515
GLU A 534
VAL A 564
M33  A1996 (-4.0A)
M33  A1996 ( 3.8A)
M33  A1996 ( 4.7A)
M33  A1996 (-3.3A)
None
None
1.05A53.82
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3WZD_A_LEVA1201_1
(VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 2)
3b2t FIBROBLAST GROWTH
FACTOR RECEPTOR 2
(Homo
sapiens)
6 / 12LEU A 487
GLY A 488
VAL A 495
ALA A 515
VAL A 564
PHE A 645
M33  A1996 (-4.0A)
M33  A1996 ( 3.8A)
M33  A1996 ( 4.7A)
M33  A1996 (-3.3A)
None
None
1.10A53.82
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3WZD_A_LEVA1201_1
(VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 2)
3b2t FIBROBLAST GROWTH
FACTOR RECEPTOR 2
(Homo
sapiens)
6 / 12LEU A 487
VAL A 495
ALA A 515
VAL A 564
GLY A 570
PHE A 645
M33  A1996 (-4.0A)
M33  A1996 ( 4.7A)
M33  A1996 (-3.3A)
None
M33  A1996 ( 4.8A)
None
0.80A53.82
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3WZD_A_LEVA1201_1
(VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 2)
3c4f BASIC FIBROBLAST
GROWTH FACTOR
RECEPTOR 1
(Homo
sapiens)
8 / 12LEU A 484
GLY A 485
VAL A 492
ALA A 512
GLU A 531
VAL A 561
GLY A 567
PHE A 642
C4F  A   1 ( 3.9A)
C4F  A   1 ( 4.5A)
None
C4F  A   1 (-3.3A)
None
C4F  A   1 ( 4.8A)
None
C4F  A   1 ( 4.5A)
0.73A55.34
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3WZD_A_LEVA1201_1
(VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 2)
3c4f BASIC FIBROBLAST
GROWTH FACTOR
RECEPTOR 1
(Homo
sapiens)
7 / 12LEU A 484
VAL A 492
ALA A 512
GLU A 531
VAL A 561
GLY A 567
LEU A 644
C4F  A   1 ( 3.9A)
None
C4F  A   1 (-3.3A)
None
C4F  A   1 ( 4.8A)
None
None
0.79A55.34
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3WZD_A_LEVA1201_1
(VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 2)
3hng VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 1
(Homo
sapiens)
7 / 12LEU A 833
GLY A 834
ALA A 859
GLU A 878
LEU A 882
VAL A 909
CYH A1039
8ST  A2001 ( 4.7A)
None
8ST  A2001 ( 3.8A)
8ST  A2001 (-3.7A)
None
8ST  A2001 (-4.1A)
8ST  A2001 (-4.2A)
0.87A67.33
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3WZD_A_LEVA1201_1
(VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 2)
3hng VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 1
(Homo
sapiens)
9 / 12LEU A 833
VAL A 841
ALA A 859
GLU A 878
LEU A 882
VAL A 909
CYH A 912
GLY A 915
CYH A1039
8ST  A2001 ( 4.7A)
8ST  A2001 ( 4.6A)
8ST  A2001 ( 3.8A)
8ST  A2001 (-3.7A)
None
8ST  A2001 (-4.1A)
8ST  A2001 (-3.8A)
None
8ST  A2001 (-4.2A)
0.52A67.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WZD_A_LEVA1201_1
(VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 2)
3lm5 SERINE/THREONINE-PRO
TEIN KINASE 17B
(Homo
sapiens)
5 / 12LEU A  39
VAL A  47
ALA A  60
LEU A  84
GLY A 116
QUE  A   1 ( 3.8A)
QUE  A   1 ( 4.6A)
QUE  A   1 (-3.2A)
QUE  A   1 ( 4.6A)
None
0.51A25.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WZD_A_LEVA1201_1
(VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 2)
3mvj CAMP-DEPENDENT
PROTEIN KINASE
CATALYTIC SUBUNIT
ALPHA
(Homo
sapiens)
5 / 12LEU A  49
VAL A  57
ALA A  70
LEU A  95
GLY A 126
XFE  A 351 (-4.2A)
XFE  A 351 ( 4.5A)
XFE  A 351 (-3.2A)
None
None
0.43A22.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WZD_A_LEVA1201_1
(VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 2)
3nuu PKB-LIKE
(Homo
sapiens)
5 / 12LEU A  88
VAL A  96
ALA A 109
GLU A 130
GLY A 165
JOZ  A 361 (-4.1A)
JOZ  A 361 ( 4.7A)
JOZ  A 361 (-3.4A)
SO4  A   5 (-3.1A)
None
0.51A26.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WZD_A_LEVA1201_1
(VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 2)
3nyo G PROTEIN-COUPLED
RECEPTOR KINASE 6
(Homo
sapiens)
5 / 12LEU A 192
VAL A 200
ALA A 213
LEU A 238
GLY A 269
AMP  A 577 ( 4.3A)
AMP  A 577 (-4.3A)
AMP  A 577 (-3.4A)
None
None
0.47A21.34
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3WZD_A_LEVA1201_1
(VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 2)
3tt0 BASIC FIBROBLAST
GROWTH FACTOR
RECEPTOR 1
(Homo
sapiens)
6 / 12LEU A 484
GLY A 485
ALA A 512
GLU A 531
VAL A 561
PHE A 642
07J  A   1 ( 4.3A)
07J  A   1 ( 4.9A)
07J  A   1 (-3.5A)
07J  A   1 (-3.8A)
07J  A   1 (-4.7A)
07J  A   1 ( 4.6A)
0.98A46.09
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3WZD_A_LEVA1201_1
(VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 2)
3tt0 BASIC FIBROBLAST
GROWTH FACTOR
RECEPTOR 1
(Homo
sapiens)
7 / 12LEU A 484
VAL A 492
ALA A 512
GLU A 531
VAL A 561
GLY A 567
LEU A 644
07J  A   1 ( 4.3A)
07J  A   1 (-4.0A)
07J  A   1 (-3.5A)
07J  A   1 (-3.8A)
07J  A   1 (-4.7A)
07J  A   1 (-3.7A)
None
0.75A46.09
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3WZD_A_LEVA1201_1
(VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 2)
3tt0 BASIC FIBROBLAST
GROWTH FACTOR
RECEPTOR 1
(Homo
sapiens)
7 / 12LEU A 484
VAL A 492
ALA A 512
GLU A 531
VAL A 561
GLY A 567
PHE A 642
07J  A   1 ( 4.3A)
07J  A   1 (-4.0A)
07J  A   1 (-3.5A)
07J  A   1 (-3.8A)
07J  A   1 (-4.7A)
07J  A   1 (-3.7A)
07J  A   1 ( 4.6A)
0.61A46.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WZD_A_LEVA1201_1
(VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 2)
3txo PROTEIN KINASE C ETA
TYPE
(Homo
sapiens)
5 / 12LEU A 361
VAL A 369
ALA A 382
LEU A 407
GLY A 439
07U  A   1 ( 4.8A)
07U  A   1 (-4.8A)
07U  A   1 (-3.3A)
None
None
0.46A24.60
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3WZD_A_LEVA1201_1
(VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 2)
3vid VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 2
(Homo
sapiens)
8 / 12LEU A 840
GLY A 841
ALA A 866
GLU A 885
LEU A 889
VAL A 916
CYH A 919
CYH A1045
4TT  A2001 ( 4.0A)
4TT  A2001 ( 4.8A)
4TT  A2001 (-3.5A)
None
None
None
4TT  A2001 (-4.3A)
None
0.79A85.92
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3WZD_A_LEVA1201_1
(VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 2)
3vid VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 2
(Homo
sapiens)
9 / 12LEU A 840
VAL A 848
ALA A 866
GLU A 885
LEU A 889
VAL A 916
CYH A 919
GLY A 922
CYH A1045
4TT  A2001 ( 4.0A)
4TT  A2001 ( 4.5A)
4TT  A2001 (-3.5A)
None
None
None
4TT  A2001 (-4.3A)
4TT  A2001 (-3.7A)
None
0.47A85.92
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3WZD_A_LEVA1201_1
(VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 2)
4agd VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 2
(Homo
sapiens)
8 / 12LEU A 840
GLY A 841
ALA A 866
GLU A 885
LEU A 889
VAL A 916
CYH A 919
CYH A1045
B49  A2000 (-3.7A)
B49  A2000 ( 4.6A)
B49  A2000 (-3.5A)
None
None
B49  A2000 (-4.8A)
B49  A2000 (-4.2A)
B49  A2000 ( 4.1A)
0.79A100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3WZD_A_LEVA1201_1
(VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 2)
4agd VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 2
(Homo
sapiens)
9 / 12LEU A 840
VAL A 848
ALA A 866
GLU A 885
LEU A 889
VAL A 916
CYH A 919
GLY A 922
CYH A1045
B49  A2000 (-3.7A)
None
B49  A2000 (-3.5A)
None
None
B49  A2000 (-4.8A)
B49  A2000 (-4.2A)
B49  A2000 ( 3.7A)
B49  A2000 ( 4.1A)
0.49A100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WZD_A_LEVA1201_1
(VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 2)
4agu CYCLIN-DEPENDENT
KINASE-LIKE 1
(Homo
sapiens)
6 / 12GLY A  11
ALA A  31
GLU A  51
LEU A  55
CYH A  83
CYH A 143
D15  A 500 (-3.8A)
D15  A 500 (-3.4A)
None
None
D15  A 500 (-4.3A)
D15  A 500 ( 4.0A)
0.77A27.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WZD_A_LEVA1201_1
(VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 2)
4agu CYCLIN-DEPENDENT
KINASE-LIKE 1
(Homo
sapiens)
6 / 12VAL A  18
ALA A  31
GLU A  51
LEU A  55
CYH A  83
CYH A 143
D15  A 500 (-4.6A)
D15  A 500 (-3.4A)
None
None
D15  A 500 (-4.3A)
D15  A 500 ( 4.0A)
0.68A27.75
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3WZD_A_LEVA1201_1
(VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 2)
4at3 BDNF/NT-3 GROWTH
FACTORS RECEPTOR
(Homo
sapiens)
6 / 12LEU A 560
GLY A 561
VAL A 568
ALA A 586
GLY A 639
PHE A 711
LTI  A1839 ( 4.2A)
LTI  A1839 ( 4.3A)
None
LTI  A1839 (-3.3A)
LTI  A1839 (-3.4A)
None
0.66A35.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WZD_A_LEVA1201_1
(VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 2)
4bc6 SERINE/THREONINE-PRO
TEIN KINASE 10
(Homo
sapiens)
6 / 12LEU A  42
VAL A  50
ALA A  63
LEU A  85
CYH A 113
GLY A 116
XZN  A1317 (-3.6A)
XZN  A1317 ( 4.7A)
XZN  A1317 (-3.5A)
None
XZN  A1317 (-3.7A)
XZN  A1317 ( 3.7A)
0.64A27.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WZD_A_LEVA1201_1
(VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 2)
4eut SERINE/THREONINE-PRO
TEIN KINASE TBK1
(Homo
sapiens)
6 / 12LEU A  15
VAL A  23
ALA A  36
GLU A  55
LEU A  59
CYH A  89
BX7  A 401 (-3.7A)
BX7  A 401 (-4.4A)
BX7  A 401 (-3.4A)
None
None
BX7  A 401 (-4.1A)
0.59A22.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WZD_A_LEVA1201_1
(VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 2)
4eut SERINE/THREONINE-PRO
TEIN KINASE TBK1
(Homo
sapiens)
6 / 12LEU A  15
VAL A  23
ALA A  36
LEU A  59
CYH A  89
GLY A  92
BX7  A 401 (-3.7A)
BX7  A 401 (-4.4A)
BX7  A 401 (-3.4A)
None
BX7  A 401 (-4.1A)
BX7  A 401 (-3.5A)
0.49A22.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WZD_A_LEVA1201_1
(VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 2)
4euu SERINE/THREONINE-PRO
TEIN KINASE TBK1
(Homo
sapiens)
7 / 12LEU A  15
VAL A  23
ALA A  36
GLU A  55
LEU A  59
CYH A  89
GLY A  92
BX7  A 401 (-3.9A)
BX7  A 401 ( 4.6A)
BX7  A 401 (-3.4A)
None
None
BX7  A 401 (-4.1A)
BX7  A 401 (-3.3A)
0.57A25.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WZD_A_LEVA1201_1
(VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 2)
4gv1 RAC-ALPHA
SERINE/THREONINE-PRO
TEIN KINASE
(Homo
sapiens)
6 / 12LEU A 156
VAL A 164
ALA A 177
GLU A 198
LEU A 202
GLY A 233
0XZ  A 501 ( 4.1A)
0XZ  A 501 (-4.5A)
0XZ  A 501 (-3.3A)
GOL  A 503 (-3.6A)
None
None
0.61A26.25
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3WZD_A_LEVA1201_1
(VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 2)
4hvi TYROSINE-PROTEIN
KINASE JAK3
(Homo
sapiens)
6 / 12LEU A 828
VAL A 836
ALA A 853
GLU A 871
LEU A 875
GLY A 908
19S  A1201 (-3.9A)
19S  A1201 (-4.4A)
19S  A1201 (-3.3A)
None
None
19S  A1201 ( 3.8A)
0.59A35.14
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3WZD_A_LEVA1201_1
(VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 2)
4hzs ACTIVATED CDC42
KINASE 1
(Homo
sapiens)
5 / 12LEU A 132
VAL A 140
ALA A 156
GLY A 211
PHE A 271
None
0.50A33.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WZD_A_LEVA1201_1
(VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 2)
4jxf SERINE/THREONINE-PRO
TEIN KINASE PLK4
(Homo
sapiens)
6 / 12LEU A  18
VAL A  26
ALA A  39
CYH A  92
GLY A  95
PHE A 155
631  A 301 (-3.4A)
631  A 301 (-4.6A)
631  A 301 (-3.3A)
631  A 301 (-4.5A)
631  A 301 ( 3.7A)
None
0.29A26.48
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3WZD_A_LEVA1201_1
(VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 2)
4k33 FIBROBLAST GROWTH
FACTOR RECEPTOR 3
(Homo
sapiens)
6 / 12LEU A 478
VAL A 486
ALA A 506
GLU A 525
VAL A 555
GLY A 561
ACP  A 801 (-3.8A)
ACP  A 801 (-4.2A)
ACP  A 801 (-3.3A)
ACP  A 801 ( 4.8A)
ACP  A 801 (-4.7A)
ACP  A 801 ( 4.6A)
0.68A51.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WZD_A_LEVA1201_1
(VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 2)
4lg4 SERINE/THREONINE-PRO
TEIN KINASE 3
(Homo
sapiens)
5 / 12LEU A  33
VAL A  41
ALA A  54
CYH A 102
GLY A 105
GOL  A 404 ( 3.6A)
GOL  A 404 (-4.5A)
GOL  A 404 ( 3.1A)
GOL  A 403 (-4.0A)
GOL  A 404 (-3.6A)
0.37A27.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WZD_A_LEVA1201_1
(VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 2)
4o38 CYCLIN-G-ASSOCIATED
KINASE
(Homo
sapiens)
6 / 12LEU A  46
ALA A  67
CYH A 126
GLY A 128
CYH A 190
PHE A 192
SIN  A 401 ( 3.9A)
SIN  A 401 ( 3.7A)
SIN  A 401 (-4.3A)
SIN  A 401 (-3.5A)
None
None
0.92A24.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WZD_A_LEVA1201_1
(VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 2)
4o38 CYCLIN-G-ASSOCIATED
KINASE
(Homo
sapiens)
7 / 12LEU A  46
VAL A  54
ALA A  67
GLU A  85
CYH A 126
GLY A 128
CYH A 190
SIN  A 401 ( 3.9A)
None
SIN  A 401 ( 3.7A)
None
SIN  A 401 (-4.3A)
SIN  A 401 (-3.5A)
None
0.79A24.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WZD_A_LEVA1201_1
(VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 2)
4oli NON-RECEPTOR
TYROSINE-PROTEIN
KINASE TYK2
(Homo
sapiens)
6 / 12LEU A 903
VAL A 911
ALA A 928
GLU A 947
LEU A 951
GLY A 984
2TT  A1202 (-3.5A)
2TT  A1202 (-4.5A)
2TT  A1202 ( 3.9A)
None
None
2TT  A1202 (-3.4A)
0.57A21.96
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3WZD_A_LEVA1201_1
(VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 2)
4rt7 RECEPTOR-TYPE
TYROSINE-PROTEIN
KINASE FLT3
(Homo
sapiens)
6 / 12LEU A 616
GLY A 617
ALA A 642
GLU A 661
CYH A 694
CYH A 828
P30  A1001 (-3.8A)
None
P30  A1001 (-3.4A)
P30  A1001 (-3.6A)
None
P30  A1001 (-4.1A)
0.78A40.71
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3WZD_A_LEVA1201_1
(VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 2)
4rt7 RECEPTOR-TYPE
TYROSINE-PROTEIN
KINASE FLT3
(Homo
sapiens)
7 / 12LEU A 616
VAL A 624
ALA A 642
GLU A 661
CYH A 694
GLY A 697
CYH A 828
P30  A1001 (-3.8A)
None
P30  A1001 (-3.4A)
P30  A1001 (-3.6A)
None
P30  A1001 (-3.4A)
P30  A1001 (-4.1A)
0.46A40.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WZD_A_LEVA1201_1
(VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 2)
4wb7 DNAJ HOMOLOG
SUBFAMILY B MEMBER
1,CAMP-DEPENDENT
PROTEIN KINASE
CATALYTIC SUBUNIT
ALPHA
(Homo
sapiens)
5 / 12LEU A 104
VAL A 112
ALA A 125
LEU A 150
GLY A 181
ATP  A 501 ( 4.3A)
ATP  A 501 (-4.0A)
ATP  A 501 (-3.4A)
None
None
0.51A22.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WZD_A_LEVA1201_1
(VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 2)
4wsq AP2-ASSOCIATED
PROTEIN KINASE 1
(Homo
sapiens)
6 / 12LEU A  52
VAL A  60
ALA A  72
CYH A 129
GLY A 132
CYH A 193
KSA  A 405 ( 4.0A)
KSA  A 405 ( 4.9A)
KSA  A 405 (-3.2A)
KSA  A 405 (-4.5A)
KSA  A 405 (-3.5A)
KSA  A 405 (-3.4A)
0.53A23.50
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3WZD_A_LEVA1201_1
(VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 2)
4xcu FIBROBLAST GROWTH
FACTOR RECEPTOR 4
(Homo
sapiens)
6 / 12LEU A 473
GLY A 474
ALA A 501
GLU A 520
VAL A 550
PHE A 631
40M  A1002 ( 4.6A)
None
40M  A1002 ( 4.1A)
40M  A1002 (-3.7A)
40M  A1002 (-4.7A)
40M  A1002 ( 4.2A)
1.00A51.77
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3WZD_A_LEVA1201_1
(VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 2)
4xcu FIBROBLAST GROWTH
FACTOR RECEPTOR 4
(Homo
sapiens)
7 / 12LEU A 473
VAL A 481
ALA A 501
GLU A 520
VAL A 550
GLY A 556
LEU A 633
40M  A1002 ( 4.6A)
40M  A1002 ( 4.5A)
40M  A1002 ( 4.1A)
40M  A1002 (-3.7A)
40M  A1002 (-4.7A)
40M  A1002 ( 3.7A)
None
0.75A51.77
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3WZD_A_LEVA1201_1
(VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 2)
4xcu FIBROBLAST GROWTH
FACTOR RECEPTOR 4
(Homo
sapiens)
7 / 12LEU A 473
VAL A 481
ALA A 501
GLU A 520
VAL A 550
GLY A 556
PHE A 631
40M  A1002 ( 4.6A)
40M  A1002 ( 4.5A)
40M  A1002 ( 4.1A)
40M  A1002 (-3.7A)
40M  A1002 (-4.7A)
40M  A1002 ( 3.7A)
40M  A1002 ( 4.2A)
0.66A51.77
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3WZD_A_LEVA1201_1
(VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 2)
4xuf RECEPTOR-TYPE
TYROSINE-PROTEIN
KINASE FLT3
(Homo
sapiens)
6 / 12LEU A 616
VAL A 624
ALA A 642
CYH A 694
GLY A 697
CYH A 828
P30  A1001 (-4.0A)
P30  A1001 ( 4.8A)
P30  A1001 (-3.5A)
P30  A1001 (-4.2A)
P30  A1001 (-3.5A)
P30  A1001 (-4.8A)
0.45A52.92
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3WZD_A_LEVA1201_1
(VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 2)
4xuf RECEPTOR-TYPE
TYROSINE-PROTEIN
KINASE FLT3
(Homo
sapiens)
6 / 12VAL A 624
ALA A 642
GLU A 661
CYH A 694
GLY A 697
CYH A 828
P30  A1001 ( 4.8A)
P30  A1001 (-3.5A)
P30  A1001 (-3.1A)
P30  A1001 (-4.2A)
P30  A1001 (-3.5A)
P30  A1001 (-4.8A)
0.51A52.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WZD_A_LEVA1201_1
(VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 2)
4z7g SERINE/THREONINE-PRO
TEIN
KINASE/ENDORIBONUCLE
ASE IRE1
(Homo
sapiens)
6 / 12LEU A 577
GLY A 578
ALA A 597
GLU A 612
LEU A 616
CYH A 645
None
0.79A22.30
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3WZD_A_LEVA1201_1
(VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 2)
5a46 FIBROBLAST GROWTH
FACTOR RECEPTOR 1
(FMS-RELATED
TYROSINE KINASE 2,
PFEIFFER SYNDROME),
ISOFORM CRA_B
(Homo
sapiens)
6 / 12LEU A 484
GLY A 485
ALA A 512
GLU A 531
VAL A 561
PHE A 642
38O  A1769 (-3.2A)
38O  A1769 ( 4.7A)
38O  A1769 (-3.6A)
EDO  A1766 (-4.1A)
38O  A1769 (-4.3A)
EDO  A1766 (-3.7A)
1.09A45.95
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3WZD_A_LEVA1201_1
(VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 2)
5a46 FIBROBLAST GROWTH
FACTOR RECEPTOR 1
(FMS-RELATED
TYROSINE KINASE 2,
PFEIFFER SYNDROME),
ISOFORM CRA_B
(Homo
sapiens)
7 / 12LEU A 484
VAL A 492
ALA A 512
GLU A 531
VAL A 561
GLY A 567
LEU A 644
38O  A1769 (-3.2A)
38O  A1769 (-4.5A)
38O  A1769 (-3.6A)
EDO  A1766 (-4.1A)
38O  A1769 (-4.3A)
38O  A1769 (-3.4A)
None
0.84A45.95
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3WZD_A_LEVA1201_1
(VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 2)
5a46 FIBROBLAST GROWTH
FACTOR RECEPTOR 1
(FMS-RELATED
TYROSINE KINASE 2,
PFEIFFER SYNDROME),
ISOFORM CRA_B
(Homo
sapiens)
7 / 12LEU A 484
VAL A 492
ALA A 512
GLU A 531
VAL A 561
GLY A 567
PHE A 642
38O  A1769 (-3.2A)
38O  A1769 (-4.5A)
38O  A1769 (-3.6A)
EDO  A1766 (-4.1A)
38O  A1769 (-4.3A)
38O  A1769 (-3.4A)
EDO  A1766 (-3.7A)
0.64A45.95
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3WZD_A_LEVA1201_1
(VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 2)
5f1z NON-RECEPTOR
TYROSINE-PROTEIN
KINASE TYK2
(Homo
sapiens)
6 / 12LEU A 903
VAL A 911
ALA A 928
GLU A 947
LEU A 951
GLY A 984
5U3  A1200 (-3.8A)
5U3  A1200 ( 4.4A)
5U3  A1200 (-3.5A)
None
None
5U3  A1200 (-3.2A)
0.52A31.90
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3WZD_A_LEVA1201_1
(VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 2)
5fm2 PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE RECEPTOR RET
(Homo
sapiens)
6 / 12LEU A 730
GLY A 731
ALA A 756
GLU A 775
LEU A 779
VAL A 804
PP1  A2012 (-4.6A)
PP1  A2012 ( 3.9A)
PP1  A2012 (-3.2A)
PP1  A2012 (-3.5A)
None
PP1  A2012 (-4.5A)
0.99A41.03
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3WZD_A_LEVA1201_1
(VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 2)
5fm2 PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE RECEPTOR RET
(Homo
sapiens)
6 / 12LEU A 730
GLY A 731
ALA A 756
LEU A 779
VAL A 804
GLY A 810
PP1  A2012 (-4.6A)
PP1  A2012 ( 3.9A)
PP1  A2012 (-3.2A)
None
PP1  A2012 (-4.5A)
PTR  A 809 (-2.4A)
0.80A41.03
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3WZD_A_LEVA1201_1
(VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 2)
5fm2 PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE RECEPTOR RET
(Homo
sapiens)
6 / 12LEU A 730
GLY A 731
ALA A 756
VAL A 804
GLY A 810
PHE A 893
PP1  A2012 (-4.6A)
PP1  A2012 ( 3.9A)
PP1  A2012 (-3.2A)
PP1  A2012 (-4.5A)
PTR  A 809 (-2.4A)
None
0.96A41.03
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3WZD_A_LEVA1201_1
(VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 2)
5fm2 PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE RECEPTOR RET
(Homo
sapiens)
6 / 12LEU A 730
VAL A 738
ALA A 756
GLU A 775
LEU A 779
VAL A 804
PP1  A2012 (-4.6A)
PP1  A2012 (-4.4A)
PP1  A2012 (-3.2A)
PP1  A2012 (-3.5A)
None
PP1  A2012 (-4.5A)
0.47A41.03
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3WZD_A_LEVA1201_1
(VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 2)
5fm2 PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE RECEPTOR RET
(Homo
sapiens)
6 / 12LEU A 730
VAL A 738
ALA A 756
LEU A 779
VAL A 804
GLY A 810
PP1  A2012 (-4.6A)
PP1  A2012 (-4.4A)
PP1  A2012 (-3.2A)
None
PP1  A2012 (-4.5A)
PTR  A 809 (-2.4A)
0.63A41.03
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3WZD_A_LEVA1201_1
(VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 2)
5fm2 PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE RECEPTOR RET
(Homo
sapiens)
6 / 12LEU A 730
VAL A 738
ALA A 756
VAL A 804
GLY A 810
PHE A 893
PP1  A2012 (-4.6A)
PP1  A2012 (-4.4A)
PP1  A2012 (-3.2A)
PP1  A2012 (-4.5A)
PTR  A 809 (-2.4A)
None
0.85A41.03
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3WZD_A_LEVA1201_1
(VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 2)
5grn PLATELET-DERIVED
GROWTH FACTOR
RECEPTOR ALPHA
(Homo
sapiens)
7 / 12LEU A 599
VAL A 607
ALA A 625
GLU A 644
CYH A 677
GLY A 680
CYH A 835
748  A1001 (-3.8A)
748  A1001 ( 4.7A)
748  A1001 (-3.7A)
748  A1001 (-3.3A)
748  A1001 (-4.5A)
748  A1001 ( 4.0A)
748  A1001 (-4.5A)
0.57A49.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WZD_A_LEVA1201_1
(VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 2)
5i3o BMP-2-INDUCIBLE
PROTEIN KINASE
(Homo
sapiens)
5 / 12LEU A  57
VAL A  65
ALA A  77
CYH A 133
GLY A 136
IDV  A 401 (-3.8A)
IDV  A 401 (-4.6A)
IDV  A 401 (-3.6A)
IDV  A 401 (-4.6A)
IDV  A 401 (-3.4A)
0.45A25.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WZD_A_LEVA1201_1
(VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 2)
6ao5 SERINE/THREONINE-PRO
TEIN KINASE 3
(Homo
sapiens)
6 / 12LEU A  33
VAL A  41
ALA A  54
CYH A 102
GLY A 105
PHE A 165
ANP  A 501 ( 3.8A)
ANP  A 501 (-4.4A)
ANP  A 501 ( 3.7A)
ANP  A 501 (-4.2A)
ANP  A 501 ( 4.0A)
None
0.63A23.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WZD_A_LEVA1201_1
(VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 2)
6c0t CGMP-DEPENDENT
PROTEIN KINASE 1
(Homo
sapiens)
5 / 12LEU A 366
VAL A 374
ALA A 388
GLU A 409
CYH A 441
EE4  A 701 ( 4.6A)
EE4  A 701 (-4.4A)
EE4  A 701 (-3.3A)
DMS  A 702 ( 4.2A)
EE4  A 701 (-4.6A)
0.55A12.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WZD_A_LEVA1201_1
(VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 2)
6c7y TYROSINE-PROTEIN
KINASE JAK1
(Homo
sapiens)
6 / 12LEU A 881
GLY A 882
ALA A 906
GLU A 925
LEU A 929
GLY A 962
ADP  A1201 ( 4.5A)
ADP  A1201 (-3.5A)
ADP  A1201 (-3.4A)
None
None
ADP  A1201 ( 4.1A)
0.74A17.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WZD_A_LEVA1201_1
(VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 2)
6c7y TYROSINE-PROTEIN
KINASE JAK1
(Homo
sapiens)
6 / 12LEU A 881
VAL A 889
ALA A 906
GLU A 925
LEU A 929
GLY A 962
ADP  A1201 ( 4.5A)
ADP  A1201 (-4.3A)
ADP  A1201 (-3.4A)
None
None
ADP  A1201 ( 4.1A)
0.69A17.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WZD_A_LEVA1201_1
(VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 2)
6fek PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE RECEPTOR RET
(Homo
sapiens)
6 / 12LEU A 730
GLY A 731
ALA A 756
GLU A 775
LEU A 779
VAL A 804
ADN  A1104 ( 4.0A)
ADN  A1104 ( 3.9A)
ADN  A1104 (-3.4A)
None
None
ADN  A1104 ( 4.6A)
0.93A23.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WZD_A_LEVA1201_1
(VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 2)
6fek PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE RECEPTOR RET
(Homo
sapiens)
6 / 12LEU A 730
GLY A 731
ALA A 756
LEU A 779
VAL A 804
GLY A 810
ADN  A1104 ( 4.0A)
ADN  A1104 ( 3.9A)
ADN  A1104 (-3.4A)
None
ADN  A1104 ( 4.6A)
ADN  A1104 ( 3.8A)
0.74A23.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WZD_A_LEVA1201_1
(VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 2)
6fek PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE RECEPTOR RET
(Homo
sapiens)
6 / 12LEU A 730
GLY A 731
ALA A 756
VAL A 804
GLY A 810
PHE A 893
ADN  A1104 ( 4.0A)
ADN  A1104 ( 3.9A)
ADN  A1104 (-3.4A)
ADN  A1104 ( 4.6A)
ADN  A1104 ( 3.8A)
None
0.96A23.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WZD_A_LEVA1201_1
(VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 2)
6fek PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE RECEPTOR RET
(Homo
sapiens)
6 / 12LEU A 730
VAL A 738
ALA A 756
GLU A 775
LEU A 779
VAL A 804
ADN  A1104 ( 4.0A)
ADN  A1104 (-4.4A)
ADN  A1104 (-3.4A)
None
None
ADN  A1104 ( 4.6A)
0.55A23.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WZD_A_LEVA1201_1
(VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 2)
6fek PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE RECEPTOR RET
(Homo
sapiens)
6 / 12LEU A 730
VAL A 738
ALA A 756
LEU A 779
VAL A 804
GLY A 810
ADN  A1104 ( 4.0A)
ADN  A1104 (-4.4A)
ADN  A1104 (-3.4A)
None
ADN  A1104 ( 4.6A)
ADN  A1104 ( 3.8A)
0.57A23.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WZD_A_LEVA1201_2
(VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 2)
1b8k PROTEIN
(NEUROTROPHIN-3)
(Homo
sapiens)
4 / 5ILE A 102
VAL A  21
LEU A  19
ASP A 105
None
1.17A15.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WZD_A_LEVA1201_2
(VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 2)
1fq3 GRANZYME B
(Homo
sapiens)
4 / 5ILE A  89
VAL A  52
LEU A  46
ASP A  50
None
1.23A22.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WZD_A_LEVA1201_2
(VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 2)
1gng GLYCOGEN SYNTHASE
KINASE-3 BETA
(Homo
sapiens)
4 / 5LYS A  85
ILE A 100
VAL A 110
LEU A 188
None
0.59A25.19
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3WZD_A_LEVA1201_2
(VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 2)
1k2p TYROSINE-PROTEIN
KINASE BTK
(Homo
sapiens)
4 / 5LYS A 430
VAL A 458
LEU A 528
ASP A 539
None
0.92A34.09
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3WZD_A_LEVA1201_2
(VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 2)
1snx TYROSINE-PROTEIN
KINASE ITK/TSK
(Homo
sapiens)
4 / 5LYS A 391
VAL A 419
LEU A 489
ASP A 500
None
0.95A33.33
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3WZD_A_LEVA1201_2
(VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 2)
1u59 TYROSINE-PROTEIN
KINASE ZAP-70
(Homo
sapiens)
4 / 5LYS A 369
ILE A 389
LEU A 468
ASP A 479
STU  A 100 ( 4.7A)
None
STU  A 100 (-4.5A)
STU  A 100 (-3.5A)
1.13A33.33
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3WZD_A_LEVA1201_2
(VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 2)
1u59 TYROSINE-PROTEIN
KINASE ZAP-70
(Homo
sapiens)
4 / 5LYS A 369
VAL A 399
LEU A 468
ASP A 479
STU  A 100 ( 4.7A)
None
STU  A 100 (-4.5A)
STU  A 100 (-3.5A)
0.97A33.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WZD_A_LEVA1201_2
(VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 2)
1unp RAC-ALPHA
SERINE/THREONINE
KINASE
(Homo
sapiens)
4 / 5ILE A   6
VAL A 106
LEU A 110
ASP A  32
None
1.08A16.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WZD_A_LEVA1201_2
(VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 2)
1z68 FIBROBLAST
ACTIVATION PROTEIN,
ALPHA SUBUNIT
(Homo
sapiens)
4 / 5ILE A 286
VAL A 312
LEU A 667
ASP A 290
None
1.16A18.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WZD_A_LEVA1201_2
(VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 2)
1zlt SERINE/THREONINE-PRO
TEIN KINASE CHK1
(Homo
sapiens)
4 / 5ILE A  58
VAL A  68
LEU A 137
ASP A 148
None
HYM  A 400 (-4.8A)
HYM  A 400 (-4.5A)
HYM  A 400 (-3.9A)
0.90A26.10
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3WZD_A_LEVA1201_2
(VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 2)
2dq7 PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE FYN
(Homo
sapiens)
4 / 5ILE X  57
VAL X  67
LEU X 137
ASP X 148
None
None
STU  X 902 (-4.4A)
STU  X 902 (-3.6A)
0.90A35.46
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3WZD_A_LEVA1201_2
(VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 2)
2dq7 PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE FYN
(Homo
sapiens)
4 / 5LYS X  39
ILE X  57
VAL X  67
LEU X 137
STU  X 902 (-3.1A)
None
None
STU  X 902 (-4.4A)
0.81A35.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WZD_A_LEVA1201_2
(VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 2)
2hak SERINE/THREONINE-PRO
TEIN KINASE MARK1
(Homo
sapiens)
4 / 5ILE A 103
VAL A 113
LEU A 182
ASP A 193
None
1.16A24.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WZD_A_LEVA1201_2
(VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 2)
2hak SERINE/THREONINE-PRO
TEIN KINASE MARK1
(Homo
sapiens)
4 / 5LYS A  82
VAL A 113
LEU A 182
ASP A 193
None
1.02A24.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WZD_A_LEVA1201_2
(VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 2)
2obv S-ADENOSYLMETHIONINE
SYNTHETASE ISOFORM
TYPE-1
(Homo
sapiens)
4 / 5LYS A 234
ILE A 196
VAL A 186
LEU A 156
None
1.08A21.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WZD_A_LEVA1201_2
(VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 2)
2x18 RAC-GAMMA
SERINE/THREONINE-PRO
TEIN KINASE
(Homo
sapiens)
4 / 5ILE A   6
VAL A 105
LEU A 109
ASP A  32
None
1.12A18.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WZD_A_LEVA1201_2
(VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 2)
3a62 RIBOSOMAL PROTEIN S6
KINASE BETA-1
(Homo
sapiens)
4 / 5LYS A 123
ILE A 146
VAL A 156
ASP A 236
STU  A 400 ( 4.3A)
None
None
STU  A 400 ( 3.8A)
0.98A26.74
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3WZD_A_LEVA1201_2
(VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 2)
3dko EPHRIN TYPE-A
RECEPTOR 7
(Homo
sapiens)
4 / 5LYS A 665
ILE A 685
VAL A 695
LEU A 765
IHZ  A1001 ( 4.5A)
IHZ  A1001 ( 4.6A)
IHZ  A1001 ( 4.9A)
IHZ  A1001 (-4.6A)
0.59A33.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WZD_A_LEVA1201_2
(VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 2)
3fe3 MAP/MICROTUBULE
AFFINITY-REGULATING
KINASE 3
(Homo
sapiens)
4 / 5LYS A  85
VAL A 116
LEU A 185
ASP A 196
None
0.94A25.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WZD_A_LEVA1201_2
(VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 2)
3g1n E3 UBIQUITIN-PROTEIN
LIGASE HUWE1
(Homo
sapiens)
4 / 5LYS A4014
ILE A4233
LEU A4062
ASP A4120
None
1.10A20.98
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3WZD_A_LEVA1201_2
(VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 2)
3hng VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 1
(Homo
sapiens)
4 / 5LYS A 861
ILE A 881
VAL A 892
LEU A1029
8ST  A2001 (-4.0A)
None
8ST  A2001 ( 4.7A)
None
0.84A67.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WZD_A_LEVA1201_2
(VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 2)
3kex RECEPTOR
TYROSINE-PROTEIN
KINASE ERBB-3
(Homo
sapiens)
4 / 5ILE A 744
VAL A 753
LEU A 822
ASP A 833
None
None
ANP  A   1 (-4.7A)
MG  A1001 ( 3.1A)
0.58A28.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WZD_A_LEVA1201_2
(VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 2)
3mi9 CELL DIVISION
PROTEIN KINASE 9
(Homo
sapiens)
4 / 5ILE A  69
VAL A  79
LEU A 156
ASP A 167
None
1.00A26.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WZD_A_LEVA1201_2
(VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 2)
3nyo G PROTEIN-COUPLED
RECEPTOR KINASE 6
(Homo
sapiens)
4 / 5ILE A 237
VAL A 247
LEU A 318
ASP A 329
None
None
AMP  A 577 (-4.8A)
AMP  A 577 (-4.0A)
1.06A21.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WZD_A_LEVA1201_2
(VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 2)
3o96 RAC-ALPHA
SERINE/THREONINE-PRO
TEIN KINASE
(Homo
sapiens)
4 / 5ILE A   6
VAL A 106
LEU A 110
ASP A  32
ILE  A   6 ( 0.4A)
VAL  A 106 ( 0.6A)
LEU  A 110 ( 0.6A)
ASP  A  32 ( 0.6A)
0.88A23.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WZD_A_LEVA1201_2
(VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 2)
4bc6 SERINE/THREONINE-PRO
TEIN KINASE 10
(Homo
sapiens)
4 / 5ILE A  84
VAL A  94
LEU A 164
ASP A 175
None
XZN  A1317 (-4.4A)
XZN  A1317 (-4.7A)
XZN  A1317 (-3.2A)
0.80A27.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WZD_A_LEVA1201_2
(VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 2)
4bc6 SERINE/THREONINE-PRO
TEIN KINASE 10
(Homo
sapiens)
4 / 5LYS A  65
VAL A  94
LEU A 164
ASP A 175
XZN  A1317 (-4.1A)
XZN  A1317 (-4.4A)
XZN  A1317 (-4.7A)
XZN  A1317 (-3.2A)
0.74A27.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WZD_A_LEVA1201_2
(VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 2)
4crs SERINE/THREONINE-PRO
TEIN KINASE N2
(Homo
sapiens)
4 / 5ILE A 708
VAL A 721
LEU A 789
ASP A 800
None
None
AGS  A1985 (-4.8A)
AGS  A1985 ( 3.3A)
1.12A25.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WZD_A_LEVA1201_2
(VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 2)
4crs SERINE/THREONINE-PRO
TEIN KINASE N2
(Homo
sapiens)
4 / 5LYS A 686
ILE A 708
VAL A 721
LEU A 789
AGS  A1985 (-3.0A)
None
None
AGS  A1985 (-4.8A)
0.92A25.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WZD_A_LEVA1201_2
(VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 2)
4e93 TYROSINE-PROTEIN
KINASE FES/FPS
(Homo
sapiens)
4 / 5ILE A 610
VAL A 620
LEU A 690
ASP A 701
None
None
GUI  A 901 (-4.3A)
GUI  A 901 ( 4.1A)
0.80A29.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WZD_A_LEVA1201_2
(VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 2)
4fmf POLIOVIRUS
RECEPTOR-RELATED
PROTEIN 1
(Homo
sapiens)
4 / 5ILE A  43
VAL A  47
LEU A  49
ASP A 118
None
1.23A19.78
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3WZD_A_LEVA1201_2
(VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 2)
4fod ALK TYROSINE KINASE
RECEPTOR
(Homo
sapiens)
4 / 5ILE A1170
VAL A1180
LEU A1256
ASP A1270
None
0UV  A1501 ( 4.9A)
0UV  A1501 (-4.6A)
0UV  A1501 ( 4.2A)
0.72A34.91
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3WZD_A_LEVA1201_2
(VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 2)
4hvi TYROSINE-PROTEIN
KINASE JAK3
(Homo
sapiens)
4 / 5LYS A 855
ILE A 874
LEU A 956
ASP A 967
19S  A1201 (-3.5A)
None
19S  A1201 (-4.5A)
19S  A1201 ( 4.1A)
1.12A35.14
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3WZD_A_LEVA1201_2
(VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 2)
4hvi TYROSINE-PROTEIN
KINASE JAK3
(Homo
sapiens)
4 / 5LYS A 855
ILE A 874
VAL A 884
LEU A 956
19S  A1201 (-3.5A)
None
None
19S  A1201 (-4.5A)
0.58A35.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WZD_A_LEVA1201_2
(VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 2)
4ks8 SERINE/THREONINE-PRO
TEIN KINASE PAK 6
(Homo
sapiens)
4 / 5LYS A 436
ILE A 455
VAL A 465
LEU A 533
None
None
None
B49  A 701 (-4.5A)
0.91A27.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WZD_A_LEVA1201_2
(VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 2)
4ks8 SERINE/THREONINE-PRO
TEIN KINASE PAK 6
(Homo
sapiens)
4 / 5LYS A 436
VAL A 465
LEU A 533
ASP A 544
None
None
B49  A 701 (-4.5A)
B49  A 701 (-4.6A)
0.76A27.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WZD_A_LEVA1201_2
(VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 2)
4lg4 SERINE/THREONINE-PRO
TEIN KINASE 3
(Homo
sapiens)
4 / 5ILE A  73
VAL A  83
LEU A 153
ASP A 164
None
GOL  A 403 (-4.1A)
GOL  A 403 ( 4.4A)
GOL  A 403 (-2.4A)
0.95A27.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WZD_A_LEVA1201_2
(VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 2)
4lg4 SERINE/THREONINE-PRO
TEIN KINASE 3
(Homo
sapiens)
4 / 5LYS A  56
VAL A  83
LEU A 153
ASP A 164
GOL  A 403 ( 4.6A)
GOL  A 403 (-4.1A)
GOL  A 403 ( 4.4A)
GOL  A 403 (-2.4A)
0.89A27.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WZD_A_LEVA1201_2
(VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 2)
4oli NON-RECEPTOR
TYROSINE-PROTEIN
KINASE TYK2
(Homo
sapiens)
4 / 5LYS A 930
ILE A 950
LEU A1030
ASP A1041
None
None
2TT  A1202 (-4.4A)
2TT  A1202 (-4.6A)
1.16A21.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WZD_A_LEVA1201_2
(VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 2)
4wsq AP2-ASSOCIATED
PROTEIN KINASE 1
(Homo
sapiens)
4 / 5LYS A  74
ILE A  93
VAL A 104
LEU A 183
None
None
None
KSA  A 405 (-4.6A)
1.03A23.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WZD_A_LEVA1201_2
(VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 2)
4xbr PROTEIN
FAM212A,SERINE/THREO
NINE-PROTEIN KINASE
PAK 4
(Homo
sapiens)
4 / 5ILE A 369
VAL A 379
LEU A 447
ASP A 458
None
None
None
ATP  A 601 ( 2.5A)
0.74A24.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WZD_A_LEVA1201_2
(VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 2)
4xbr PROTEIN
FAM212A,SERINE/THREO
NINE-PROTEIN KINASE
PAK 4
(Homo
sapiens)
4 / 5LYS A 350
ILE A 369
VAL A 379
ASP A 458
ATP  A 601 (-2.8A)
None
None
ATP  A 601 ( 2.5A)
1.04A24.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WZD_A_LEVA1201_2
(VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 2)
4yhj G PROTEIN-COUPLED
RECEPTOR KINASE 4
(Homo
sapiens)
4 / 5ILE A 238
VAL A 248
LEU A 319
ASP A 330
None
None
None
AN2  A 601 (-3.0A)
1.10A20.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WZD_A_LEVA1201_2
(VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 2)
4zg7 ECTONUCLEOTIDE
PYROPHOSPHATASE/PHOS
PHODIESTERASE FAMILY
MEMBER 2
(Homo
sapiens)
4 / 5LYS A 191
ILE A 152
VAL A 354
LEU A 339
None
1.23A16.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WZD_A_LEVA1201_2
(VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 2)
5es1 MAP/MICROTUBULE
AFFINITY-REGULATING
KINASE 4
(Homo
sapiens)
5 / 5LYS A  85
ILE A 106
VAL A 116
LEU A 185
ASP A 196
5RC  A4000 (-2.8A)
None
None
None
5RC  A4000 (-3.6A)
1.17A24.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WZD_A_LEVA1201_2
(VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 2)
5i3o BMP-2-INDUCIBLE
PROTEIN KINASE
(Homo
sapiens)
4 / 5LYS A  79
ILE A  98
VAL A 109
LEU A 187
IDV  A 401 ( 4.8A)
None
None
IDV  A 401 (-4.4A)
0.74A25.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WZD_A_LEVA1201_2
(VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 2)
5j5t MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE KINASE KINASE
3
(Homo
sapiens)
4 / 5LYS A  45
VAL A  74
LEU A 143
ASP A 154
6G2  A 901 ( 3.9A)
None
6G2  A 901 (-4.7A)
6G2  A 901 (-3.4A)
0.94A22.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WZD_A_LEVA1201_2
(VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 2)
5myv SRSF PROTEIN KINASE
2,SRSF PROTEIN
KINASE 2
(Homo
sapiens)
4 / 5LYS A 121
VAL A 157
LEU A 232
ASP A 541
SO4  A 702 (-3.3A)
DMS  A 717 (-4.3A)
None
DMS  A 717 (-4.3A)
0.97A24.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WZD_A_LEVA1201_2
(VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 2)
5ulm MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE KINASE 5
(Homo
sapiens)
4 / 5LYS A 512
ILE A 520
LEU A 392
ASP A 399
None
0.99A22.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WZD_A_LEVA1201_2
(VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 2)
5vef SERINE/THREONINE-PRO
TEIN KINASE PAK 4
(Homo
sapiens)
4 / 5ILE A 369
VAL A 379
LEU A 447
ASP A 458
None
None
M77  A 601 (-4.6A)
M77  A 601 ( 3.5A)
1.17A26.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WZD_A_LEVA1201_2
(VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 2)
6b3e CYCLIN-DEPENDENT
KINASE 12
(Homo
sapiens)
4 / 5ILE A 777
VAL A 787
LEU A 866
ASP A 877
None
None
CJM  A1102 (-4.4A)
MG  A1101 (-2.5A)
0.91A15.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WZD_A_LEVA1201_2
(VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 2)
6c7y TYROSINE-PROTEIN
KINASE JAK1
(Homo
sapiens)
4 / 5LYS A 908
ILE A 928
LEU A1010
ASP A1021
ADP  A1201 (-2.8A)
None
ADP  A1201 (-4.5A)
MG  A1203 (-1.8A)
1.17A17.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WZD_A_LEVA1201_2
(VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 2)
6c7y TYROSINE-PROTEIN
KINASE JAK1
(Homo
sapiens)
4 / 5LYS A 908
ILE A 928
VAL A 938
LEU A1010
ADP  A1201 (-2.8A)
None
None
ADP  A1201 (-4.5A)
0.83A17.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WZD_A_LEVA1201_2
(VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 2)
6c9d SERINE/THREONINE-PRO
TEIN KINASE
MARK1,SERINE/THREONI
NE-PROTEIN KINASE
MARK1
(Homo
sapiens)
4 / 5ILE A 110
VAL A 120
LEU A 189
ASP A 200
None
1.22A11.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WZD_A_LEVA1201_2
(VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 2)
6c9d SERINE/THREONINE-PRO
TEIN KINASE
MARK1,SERINE/THREONI
NE-PROTEIN KINASE
MARK1
(Homo
sapiens)
4 / 5LYS A  89
ILE A 110
VAL A 120
LEU A 189
None
1.00A11.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WZD_A_LEVA1201_2
(VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 2)
6ccf CALCIUM/CALMODULIN-D
EPENDENT PROTEIN
KINASE KINASE 1
(Homo
sapiens)
4 / 5LYS A 157
VAL A 212
LEU A 282
ASP A 293
H1N  A 501 (-2.8A)
H1N  A 501 (-4.9A)
H1N  A 501 (-4.8A)
H1N  A 501 (-3.5A)
1.10A17.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WZD_A_LEVA1201_2
(VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 2)
6cmj CALCIUM/CALMODULIN-D
EPENDENT PROTEIN
KINASE KINASE 2
(Homo
sapiens)
5 / 5LYS A 194
ILE A 239
VAL A 249
LEU A 319
ASP A 330
F6J  A 501 (-2.9A)
None
None
F6J  A 501 (-4.5A)
F6J  A 501 (-3.8A)
1.09A14.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WZD_A_LEVA1201_2
(VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 2)
6f3d INTERLEUKIN-1
RECEPTOR-ASSOCIATED
KINASE 4
(Homo
sapiens)
4 / 5LYS A 213
VAL A 246
LEU A 318
ASP A 329
CJT  A 502 (-3.0A)
None
CJT  A 502 (-4.7A)
CJT  A 502 ( 4.0A)
1.01A15.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZV2_A_LEVA801_1
(FIBROBLAST GROWTH
FACTOR RECEPTOR 1)
1rjb FL CYTOKINE RECEPTOR
(Homo
sapiens)
7 / 12LEU A 616
GLY A 617
VAL A 624
ALA A 642
GLU A 661
TYR A 693
GLY A 697
None
0.88A15.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZV2_A_LEVA801_1
(FIBROBLAST GROWTH
FACTOR RECEPTOR 1)
1t46 HOMO SAPIENS V-KIT
HARDY-ZUCKERMAN 4
FELINE SARCOMA VIRAL
ONCOGENE HOMOLOG
(Homo
sapiens)
6 / 12LEU A 595
VAL A 603
ALA A 621
GLU A 640
TYR A 672
GLY A 676
STI  A   3 ( 3.8A)
STI  A   3 ( 4.6A)
STI  A   3 (-3.5A)
STI  A   3 (-3.6A)
STI  A   3 ( 4.0A)
STI  A   3 ( 3.8A)
0.45A18.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZV2_A_LEVA801_1
(FIBROBLAST GROWTH
FACTOR RECEPTOR 1)
1u59 TYROSINE-PROTEIN
KINASE ZAP-70
(Homo
sapiens)
7 / 12LEU A 344
VAL A 352
ALA A 367
GLU A 386
MET A 390
ALA A 417
GLY A 420
STU  A 100 (-3.8A)
STU  A 100 (-4.8A)
STU  A 100 (-3.2A)
None
None
STU  A 100 (-3.7A)
STU  A 100 (-3.5A)
0.47A15.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZV2_A_LEVA801_1
(FIBROBLAST GROWTH
FACTOR RECEPTOR 1)
1zlt SERINE/THREONINE-PRO
TEIN KINASE CHK1
(Homo
sapiens)
6 / 12LEU A  15
VAL A  23
ALA A  36
GLU A  55
TYR A  86
GLY A  90
HYM  A 400 (-4.2A)
HYM  A 400 (-4.3A)
HYM  A 400 (-3.5A)
None
HYM  A 400 (-4.7A)
None
0.44A22.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZV2_A_LEVA801_1
(FIBROBLAST GROWTH
FACTOR RECEPTOR 1)
2dq7 PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE FYN
(Homo
sapiens)
7 / 12LEU X  17
GLY X  18
ALA X  37
GLU X  54
MET X  58
TYR X  84
ALA X 147
STU  X 902 (-3.8A)
STU  X 902 ( 3.7A)
STU  X 902 (-3.1A)
STU  X 902 ( 4.4A)
None
STU  X 902 (-4.6A)
STU  X 902 ( 4.1A)
1.08A16.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZV2_A_LEVA801_1
(FIBROBLAST GROWTH
FACTOR RECEPTOR 1)
2dq7 PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE FYN
(Homo
sapiens)
8 / 12LEU X  17
VAL X  25
ALA X  37
GLU X  54
MET X  58
TYR X  84
GLY X  88
ALA X 147
STU  X 902 (-3.8A)
STU  X 902 ( 4.8A)
STU  X 902 (-3.1A)
STU  X 902 ( 4.4A)
None
STU  X 902 (-4.6A)
STU  X 902 (-3.5A)
STU  X 902 ( 4.1A)
0.62A16.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZV2_A_LEVA801_1
(FIBROBLAST GROWTH
FACTOR RECEPTOR 1)
2h8h PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC
(Homo
sapiens)
6 / 12LEU A 273
VAL A 281
ALA A 293
TYR A 340
GLY A 344
ALA A 403
H8H  A 534 (-3.8A)
H8H  A 534 (-4.4A)
H8H  A 534 (-3.2A)
H8H  A 534 (-4.3A)
H8H  A 534 (-3.3A)
H8H  A 534 ( 4.0A)
0.63A9.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZV2_A_LEVA801_1
(FIBROBLAST GROWTH
FACTOR RECEPTOR 1)
2hak SERINE/THREONINE-PRO
TEIN KINASE MARK1
(Homo
sapiens)
7 / 12VAL A  67
ALA A  80
MET A 104
TYR A 131
ALA A 132
GLY A 135
ALA A 192
None
0.96A14.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZV2_A_LEVA801_1
(FIBROBLAST GROWTH
FACTOR RECEPTOR 1)
2hk5 TYROSINE-PROTEIN
KINASE HCK
(Homo
sapiens)
7 / 12LEU A 251
VAL A 259
ALA A 271
GLU A 288
MET A 292
GLY A 322
ALA A 381
1BM  A 499 ( 3.7A)
1BM  A 499 ( 4.8A)
1BM  A 499 (-3.6A)
1BM  A 499 (-3.2A)
1BM  A 499 ( 3.8A)
1BM  A 499 (-3.5A)
1BM  A 499 ( 3.7A)
1.05A15.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZV2_A_LEVA801_1
(FIBROBLAST GROWTH
FACTOR RECEPTOR 1)
2hz0 PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1
(Homo
sapiens)
7 / 12LEU A 248
VAL A 256
ALA A 269
GLU A 286
MET A 290
GLY A 321
ALA A 380
GIN  A 600 ( 4.6A)
GIN  A 600 ( 4.7A)
GIN  A 600 (-3.1A)
GIN  A 600 (-3.6A)
GIN  A 600 (-3.2A)
None
GIN  A 600 (-3.1A)
0.67A16.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZV2_A_LEVA801_1
(FIBROBLAST GROWTH
FACTOR RECEPTOR 1)
2i0e PROTEIN KINASE
C-BETA II
(Homo
sapiens)
6 / 12LEU A 348
VAL A 356
ALA A 369
GLU A 390
TYR A 422
ALA A 483
PDS  A 901 (-3.9A)
PDS  A 901 (-4.2A)
PDS  A 901 (-3.3A)
None
PDS  A 901 (-4.7A)
PDS  A 901 (-3.4A)
0.70A14.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZV2_A_LEVA801_1
(FIBROBLAST GROWTH
FACTOR RECEPTOR 1)
2og8 PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE LCK
(Homo
sapiens)
8 / 12LEU A 251
PHE A 383
VAL A 259
ALA A 271
GLU A 288
MET A 292
GLY A 322
ALA A 381
None
1N8  A 501 ( 4.3A)
None
1N8  A 501 ( 3.4A)
1N8  A 501 ( 3.6A)
1N8  A 501 ( 3.6A)
1N8  A 501 ( 3.5A)
1N8  A 501 ( 3.3A)
0.88A20.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZV2_A_LEVA801_1
(FIBROBLAST GROWTH
FACTOR RECEPTOR 1)
2og8 PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE LCK
(Homo
sapiens)
8 / 12LEU A 251
VAL A 259
ALA A 271
GLU A 288
MET A 292
TYR A 318
GLY A 322
ALA A 381
None
None
1N8  A 501 ( 3.4A)
1N8  A 501 ( 3.6A)
1N8  A 501 ( 3.6A)
1N8  A 501 ( 3.7A)
1N8  A 501 ( 3.5A)
1N8  A 501 ( 3.3A)
0.73A20.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZV2_A_LEVA801_1
(FIBROBLAST GROWTH
FACTOR RECEPTOR 1)
2ogv MACROPHAGE
COLONY-STIMULATING
FACTOR 1 RECEPTOR
PRECURSOR
(Homo
sapiens)
7 / 12LEU A 588
GLY A 589
ALA A 614
GLU A 633
MET A 637
TYR A 665
GLY A 669
None
0.96A24.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZV2_A_LEVA801_1
(FIBROBLAST GROWTH
FACTOR RECEPTOR 1)
2ogv MACROPHAGE
COLONY-STIMULATING
FACTOR 1 RECEPTOR
PRECURSOR
(Homo
sapiens)
7 / 12LEU A 588
VAL A 596
ALA A 614
GLU A 633
MET A 637
TYR A 665
GLY A 669
None
0.58A24.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZV2_A_LEVA801_1
(FIBROBLAST GROWTH
FACTOR RECEPTOR 1)
2p4i ANGIOPOIETIN-1
RECEPTOR
(Homo
sapiens)
6 / 12VAL A 838
ALA A 853
TYR A 904
ALA A 905
GLY A 908
ALA A 981
MR9  A 301 (-4.6A)
MR9  A 301 (-3.5A)
MR9  A 301 (-3.8A)
MR9  A 301 (-3.6A)
MR9  A 301 ( 3.8A)
MR9  A 301 (-3.2A)
0.69A12.90
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5ZV2_A_LEVA801_1
(FIBROBLAST GROWTH
FACTOR RECEPTOR 1)
2psq FIBROBLAST GROWTH
FACTOR RECEPTOR 2
(Homo
sapiens)
11 / 12LEU A 487
GLY A 488
VAL A 495
ALA A 515
GLU A 534
MET A 538
VAL A 564
TYR A 566
ALA A 567
GLY A 570
ALA A 643
None
0.53A45.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZV2_A_LEVA801_1
(FIBROBLAST GROWTH
FACTOR RECEPTOR 1)
2vd5 DMPK PROTEIN
(Homo
sapiens)
6 / 12VAL A  85
ALA A  98
GLU A 119
TYR A 150
GLY A 154
ALA A 212
BI8  A1417 ( 4.7A)
BI8  A1417 ( 3.8A)
BI8  A1417 ( 4.9A)
BI8  A1417 (-4.8A)
None
BI8  A1417 ( 4.1A)
0.77A11.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZV2_A_LEVA801_1
(FIBROBLAST GROWTH
FACTOR RECEPTOR 1)
2x4f MYOSIN LIGHT CHAIN
KINASE FAMILY MEMBER
4
(Homo
sapiens)
6 / 12LEU A 112
VAL A 120
ALA A 133
MET A 155
TYR A 182
GLY A 186
16X  A1374 (-4.1A)
16X  A1374 (-4.8A)
16X  A1374 ( 3.8A)
None
16X  A1374 (-4.1A)
16X  A1374 (-4.0A)
0.58A14.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZV2_A_LEVA801_1
(FIBROBLAST GROWTH
FACTOR RECEPTOR 1)
2xik SERINE/THREONINE
PROTEIN KINASE 25
(Homo
sapiens)
6 / 12GLY A  27
ALA A  47
GLU A  66
TYR A  97
GLY A 101
ALA A 157
J60  A1294 ( 4.1A)
J60  A1294 (-3.3A)
None
J60  A1294 (-4.5A)
J60  A1294 ( 3.8A)
J60  A1294 ( 4.2A)
0.77A14.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZV2_A_LEVA801_1
(FIBROBLAST GROWTH
FACTOR RECEPTOR 1)
2xik SERINE/THREONINE
PROTEIN KINASE 25
(Homo
sapiens)
6 / 12VAL A  34
ALA A  47
GLU A  66
TYR A  97
GLY A 101
ALA A 157
J60  A1294 ( 4.9A)
J60  A1294 (-3.3A)
None
J60  A1294 (-4.5A)
J60  A1294 ( 3.8A)
J60  A1294 ( 4.2A)
0.57A14.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZV2_A_LEVA801_1
(FIBROBLAST GROWTH
FACTOR RECEPTOR 1)
2z8c INSULIN RECEPTOR
(Homo
sapiens)
6 / 12LEU A1002
VAL A1010
ALA A1028
GLU A1047
MET A1051
GLY A1082
S91  A   1 ( 4.1A)
S91  A   1 ( 4.9A)
S91  A   1 (-3.2A)
None
None
S91  A   1 (-3.3A)
0.69A13.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZV2_A_LEVA801_1
(FIBROBLAST GROWTH
FACTOR RECEPTOR 1)
3a62 RIBOSOMAL PROTEIN S6
KINASE BETA-1
(Homo
sapiens)
6 / 12LEU A  97
VAL A 105
ALA A 121
GLU A 143
TYR A 174
GLY A 178
STU  A 400 (-3.8A)
STU  A 400 (-4.9A)
STU  A 400 (-3.1A)
STU  A 400 ( 4.3A)
STU  A 400 (-4.7A)
STU  A 400 ( 4.4A)
0.47A13.21
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5ZV2_A_LEVA801_1
(FIBROBLAST GROWTH
FACTOR RECEPTOR 1)
3b2t FIBROBLAST GROWTH
FACTOR RECEPTOR 2
(Homo
sapiens)
9 / 12LEU A 487
GLY A 488
VAL A 495
ALA A 515
GLU A 534
MET A 538
VAL A 564
TYR A 566
ALA A 567
M33  A1996 (-4.0A)
M33  A1996 ( 3.8A)
M33  A1996 ( 4.7A)
M33  A1996 (-3.3A)
None
None
None
M33  A1996 ( 4.7A)
M33  A1996 (-3.8A)
1.02A75.29
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5ZV2_A_LEVA801_1
(FIBROBLAST GROWTH
FACTOR RECEPTOR 1)
3b2t FIBROBLAST GROWTH
FACTOR RECEPTOR 2
(Homo
sapiens)
9 / 12LEU A 487
GLY A 488
VAL A 495
ALA A 515
MET A 538
VAL A 564
TYR A 566
ALA A 567
ALA A 643
M33  A1996 (-4.0A)
M33  A1996 ( 3.8A)
M33  A1996 ( 4.7A)
M33  A1996 (-3.3A)
None
None
M33  A1996 ( 4.7A)
M33  A1996 (-3.8A)
None
0.93A75.29
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5ZV2_A_LEVA801_1
(FIBROBLAST GROWTH
FACTOR RECEPTOR 1)
3b2t FIBROBLAST GROWTH
FACTOR RECEPTOR 2
(Homo
sapiens)
9 / 12LEU A 487
VAL A 495
ALA A 515
MET A 538
VAL A 564
TYR A 566
ALA A 567
GLY A 570
ALA A 643
M33  A1996 (-4.0A)
M33  A1996 ( 4.7A)
M33  A1996 (-3.3A)
None
None
M33  A1996 ( 4.7A)
M33  A1996 (-3.8A)
M33  A1996 ( 4.8A)
None
0.46A75.29
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5ZV2_A_LEVA801_1
(FIBROBLAST GROWTH
FACTOR RECEPTOR 1)
3c4f BASIC FIBROBLAST
GROWTH FACTOR
RECEPTOR 1
(Homo
sapiens)
7 / 12GLY A 487
PHE A 489
VAL A 492
GLU A 531
MET A 535
VAL A 561
ALA A 640
None
C4F  A   1 (-3.7A)
None
None
C4F  A   1 ( 3.7A)
C4F  A   1 ( 4.8A)
C4F  A   1 (-3.6A)
1.34A100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5ZV2_A_LEVA801_1
(FIBROBLAST GROWTH
FACTOR RECEPTOR 1)
3c4f BASIC FIBROBLAST
GROWTH FACTOR
RECEPTOR 1
(Homo
sapiens)
12 / 12LEU A 484
GLY A 485
PHE A 489
VAL A 492
ALA A 512
GLU A 531
MET A 535
VAL A 561
TYR A 563
ALA A 564
GLY A 567
ALA A 640
C4F  A   1 ( 3.9A)
C4F  A   1 ( 4.5A)
C4F  A   1 (-3.7A)
None
C4F  A   1 (-3.3A)
None
C4F  A   1 ( 3.7A)
C4F  A   1 ( 4.8A)
None
C4F  A   1 (-3.5A)
None
C4F  A   1 (-3.6A)
0.50A100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZV2_A_LEVA801_1
(FIBROBLAST GROWTH
FACTOR RECEPTOR 1)
3d7u TYROSINE-PROTEIN
KINASE CSK
(Homo
sapiens)
6 / 12VAL A 209
ALA A 220
GLU A 236
MET A 240
TYR A 268
GLY A 272
None
0.62A15.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZV2_A_LEVA801_1
(FIBROBLAST GROWTH
FACTOR RECEPTOR 1)
3fe3 MAP/MICROTUBULE
AFFINITY-REGULATING
KINASE 3
(Homo
sapiens)
7 / 12VAL A  70
ALA A  83
MET A 107
TYR A 134
ALA A 135
GLY A 138
ALA A 195
None
0.83A11.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZV2_A_LEVA801_1
(FIBROBLAST GROWTH
FACTOR RECEPTOR 1)
3hng VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 1
(Homo
sapiens)
7 / 12LEU A 833
VAL A 841
ALA A 859
GLU A 878
VAL A 909
TYR A 911
GLY A 915
8ST  A2001 ( 4.7A)
8ST  A2001 ( 4.6A)
8ST  A2001 ( 3.8A)
8ST  A2001 (-3.7A)
8ST  A2001 (-4.1A)
8ST  A2001 (-4.9A)
None
0.23A14.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZV2_A_LEVA801_1
(FIBROBLAST GROWTH
FACTOR RECEPTOR 1)
3iec SERINE/THREONINE-PRO
TEIN KINASE MARK2
(Homo
sapiens)
7 / 12VAL A  67
ALA A  80
MET A 104
TYR A 131
ALA A 132
GLY A 135
ALA A 192
None
0.71A13.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZV2_A_LEVA801_1
(FIBROBLAST GROWTH
FACTOR RECEPTOR 1)
3lm5 SERINE/THREONINE-PRO
TEIN KINASE 17B
(Homo
sapiens)
7 / 12LEU A  39
VAL A  47
ALA A  60
GLU A  80
TYR A 112
ALA A 113
GLY A 116
QUE  A   1 ( 3.8A)
QUE  A   1 ( 4.6A)
QUE  A   1 (-3.2A)
QUE  A   1 (-3.1A)
QUE  A   1 (-4.9A)
QUE  A   1 (-3.9A)
None
0.67A12.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZV2_A_LEVA801_1
(FIBROBLAST GROWTH
FACTOR RECEPTOR 1)
3mdy BONE MORPHOGENETIC
PROTEIN RECEPTOR
TYPE-1B
(Homo
sapiens)
6 / 12VAL A 218
ALA A 229
GLU A 244
TYR A 281
GLY A 285
ALA A 349
LDN  A   1 ( 4.8A)
LDN  A   1 (-3.6A)
None
LDN  A   1 ( 4.8A)
LDN  A   1 (-3.3A)
LDN  A   1 ( 3.8A)
0.77A12.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZV2_A_LEVA801_1
(FIBROBLAST GROWTH
FACTOR RECEPTOR 1)
3mvj CAMP-DEPENDENT
PROTEIN KINASE
CATALYTIC SUBUNIT
ALPHA
(Homo
sapiens)
6 / 12LEU A  49
VAL A  57
ALA A  70
GLU A  91
TYR A 122
GLY A 126
XFE  A 351 (-4.2A)
XFE  A 351 ( 4.5A)
XFE  A 351 (-3.2A)
None
None
None
0.44A15.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZV2_A_LEVA801_1
(FIBROBLAST GROWTH
FACTOR RECEPTOR 1)
3nuu PKB-LIKE
(Homo
sapiens)
8 / 12LEU A  88
VAL A  96
ALA A 109
GLU A 130
MET A 134
TYR A 161
ALA A 162
GLY A 165
JOZ  A 361 (-4.1A)
JOZ  A 361 ( 4.7A)
JOZ  A 361 (-3.4A)
SO4  A   5 (-3.1A)
None
None
JOZ  A 361 (-3.8A)
None
0.56A15.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZV2_A_LEVA801_1
(FIBROBLAST GROWTH
FACTOR RECEPTOR 1)
3qfv CDC42BPB PROTEIN
(Homo
sapiens)
6 / 12VAL A  90
ALA A 103
GLU A 124
TYR A 155
GLY A 159
ALA A 217
NM7  A 416 (-3.7A)
NM7  A 416 ( 3.7A)
EDO  A 417 (-4.0A)
NM7  A 416 (-4.4A)
None
NM7  A 416 ( 4.5A)
0.76A13.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZV2_A_LEVA801_1
(FIBROBLAST GROWTH
FACTOR RECEPTOR 1)
3s95 LIM DOMAIN KINASE 1
(Homo
sapiens)
6 / 12LEU A 345
GLU A 384
MET A 388
TYR A 415
GLY A 419
ALA A 477
STU  A   1 (-3.8A)
STU  A   1 (-3.7A)
None
STU  A   1 (-4.7A)
STU  A   1 (-3.6A)
STU  A   1 ( 4.1A)
0.80A14.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZV2_A_LEVA801_1
(FIBROBLAST GROWTH
FACTOR RECEPTOR 1)
3sxs CYTOPLASMIC
TYROSINE-PROTEIN
KINASE BMX
(Homo
sapiens)
6 / 12LEU A 423
VAL A 431
ALA A 443
MET A 464
TYR A 491
GLY A 495
PP2  A   1 (-4.1A)
PP2  A   1 (-4.5A)
PP2  A   1 (-3.2A)
PP2  A   1 ( 4.3A)
PP2  A   1 ( 4.9A)
PP2  A   1 ( 4.2A)
0.72A14.08
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5ZV2_A_LEVA801_1
(FIBROBLAST GROWTH
FACTOR RECEPTOR 1)
3tt0 BASIC FIBROBLAST
GROWTH FACTOR
RECEPTOR 1
(Homo
sapiens)
9 / 12LEU A 484
GLY A 485
ALA A 512
GLU A 531
MET A 535
VAL A 561
TYR A 563
ALA A 564
ALA A 640
07J  A   1 ( 4.3A)
07J  A   1 ( 4.9A)
07J  A   1 (-3.5A)
07J  A   1 (-3.8A)
07J  A   1 (-3.8A)
07J  A   1 (-4.7A)
07J  A   1 (-4.7A)
07J  A   1 (-3.8A)
07J  A   1 (-3.2A)
0.90A59.85
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5ZV2_A_LEVA801_1
(FIBROBLAST GROWTH
FACTOR RECEPTOR 1)
3tt0 BASIC FIBROBLAST
GROWTH FACTOR
RECEPTOR 1
(Homo
sapiens)
10 / 12LEU A 484
VAL A 492
ALA A 512
GLU A 531
MET A 535
VAL A 561
TYR A 563
ALA A 564
GLY A 567
ALA A 640
07J  A   1 ( 4.3A)
07J  A   1 (-4.0A)
07J  A   1 (-3.5A)
07J  A   1 (-3.8A)
07J  A   1 (-3.8A)
07J  A   1 (-4.7A)
07J  A   1 (-4.7A)
07J  A   1 (-3.8A)
07J  A   1 (-3.7A)
07J  A   1 (-3.2A)
0.36A59.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZV2_A_LEVA801_1
(FIBROBLAST GROWTH
FACTOR RECEPTOR 1)
3txo PROTEIN KINASE C ETA
TYPE
(Homo
sapiens)
6 / 12LEU A 361
VAL A 369
ALA A 382
GLU A 403
GLY A 439
ALA A 496
07U  A   1 ( 4.8A)
07U  A   1 (-4.8A)
07U  A   1 (-3.3A)
07U  A   1 ( 4.8A)
None
07U  A   1 ( 4.0A)
0.79A11.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZV2_A_LEVA801_1
(FIBROBLAST GROWTH
FACTOR RECEPTOR 1)
3vid VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 2
(Homo
sapiens)
6 / 12LEU A 840
VAL A 848
ALA A 866
GLU A 885
VAL A 916
GLY A 922
4TT  A2001 ( 4.0A)
4TT  A2001 ( 4.5A)
4TT  A2001 (-3.5A)
None
None
4TT  A2001 (-3.7A)
0.29A15.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZV2_A_LEVA801_1
(FIBROBLAST GROWTH
FACTOR RECEPTOR 1)
3w18 AURORA KINASE A
(Homo
sapiens)
7 / 12LEU A 139
VAL A 147
ALA A 160
TYR A 212
ALA A 213
GLY A 216
ALA A 273
N13  A 501 (-3.7A)
N13  A 501 ( 4.7A)
N13  A 501 ( 4.1A)
N13  A 501 (-4.4A)
N13  A 501 (-3.7A)
N13  A 501 (-3.5A)
N13  A 501 ( 3.8A)
0.39A13.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZV2_A_LEVA801_1
(FIBROBLAST GROWTH
FACTOR RECEPTOR 1)
3wzd VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 2
(Homo
sapiens)
7 / 12LEU A 840
GLY A 841
VAL A 848
ALA A 866
GLU A 885
VAL A 916
GLY A 922
LEV  A1201 ( 3.8A)
LEV  A1201 (-3.1A)
LEV  A1201 ( 4.9A)
LEV  A1201 (-3.5A)
LEV  A1201 (-3.7A)
LEV  A1201 ( 4.6A)
LEV  A1201 (-3.6A)
0.37A16.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZV2_A_LEVA801_1
(FIBROBLAST GROWTH
FACTOR RECEPTOR 1)
4af3 AURORA KINASE B
(Homo
sapiens)
7 / 12LEU A  83
GLY A  84
PHE A  88
VAL A  91
TYR A 156
ALA A 157
GLY A 160
VX6  A 500 (-3.8A)
VX6  A 500 ( 4.1A)
VX6  A 500 (-3.4A)
VX6  A 500 ( 4.8A)
VX6  A 500 (-4.2A)
VX6  A 500 (-3.7A)
VX6  A 500 (-3.3A)
1.19A13.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZV2_A_LEVA801_1
(FIBROBLAST GROWTH
FACTOR RECEPTOR 1)
4af3 AURORA KINASE B
(Homo
sapiens)
8 / 12LEU A  83
GLY A  84
VAL A  91
ALA A 104
TYR A 156
ALA A 157
GLY A 160
ALA A 217
VX6  A 500 (-3.8A)
VX6  A 500 ( 4.1A)
VX6  A 500 ( 4.8A)
VX6  A 500 (-3.4A)
VX6  A 500 (-4.2A)
VX6  A 500 (-3.7A)
VX6  A 500 (-3.3A)
VX6  A 500 ( 4.2A)
0.80A13.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZV2_A_LEVA801_1
(FIBROBLAST GROWTH
FACTOR RECEPTOR 1)
4agd VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 2
(Homo
sapiens)
7 / 12LEU A 840
GLY A 841
PHE A1047
ALA A 866
GLU A 885
VAL A 916
GLY A 922
B49  A2000 (-3.7A)
B49  A2000 ( 4.6A)
B49  A2000 (-4.0A)
B49  A2000 (-3.5A)
None
B49  A2000 (-4.8A)
B49  A2000 ( 3.7A)
1.22A15.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZV2_A_LEVA801_1
(FIBROBLAST GROWTH
FACTOR RECEPTOR 1)
4agd VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 2
(Homo
sapiens)
7 / 12LEU A 840
PHE A1047
VAL A 848
ALA A 866
GLU A 885
VAL A 916
GLY A 922
B49  A2000 (-3.7A)
B49  A2000 (-4.0A)
None
B49  A2000 (-3.5A)
None
B49  A2000 (-4.8A)
B49  A2000 ( 3.7A)
0.84A15.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZV2_A_LEVA801_1
(FIBROBLAST GROWTH
FACTOR RECEPTOR 1)
4at3 BDNF/NT-3 GROWTH
FACTORS RECEPTOR
(Homo
sapiens)
6 / 12LEU A 560
GLY A 561
PHE A 565
VAL A 568
ALA A 586
GLY A 639
LTI  A1839 ( 4.2A)
LTI  A1839 ( 4.3A)
LTI  A1839 (-3.5A)
None
LTI  A1839 (-3.3A)
LTI  A1839 (-3.4A)
0.60A12.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZV2_A_LEVA801_1
(FIBROBLAST GROWTH
FACTOR RECEPTOR 1)
4at3 BDNF/NT-3 GROWTH
FACTORS RECEPTOR
(Homo
sapiens)
6 / 12LEU A 560
GLY A 561
VAL A 568
ALA A 586
TYR A 635
GLY A 639
LTI  A1839 ( 4.2A)
LTI  A1839 ( 4.3A)
None
LTI  A1839 (-3.3A)
LTI  A1839 (-4.7A)
LTI  A1839 (-3.4A)
0.60A12.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZV2_A_LEVA801_1
(FIBROBLAST GROWTH
FACTOR RECEPTOR 1)
4ckr EPITHELIAL DISCOIDIN
DOMAIN-CONTAINING
RECEPTOR 1
(Homo
sapiens)
7 / 12LEU A 616
GLY A 617
ALA A 653
GLU A 672
MET A 676
TYR A 703
ALA A 783
None
None
DI1  A1000 (-3.6A)
DI1  A1000 (-3.8A)
DI1  A1000 (-3.6A)
DI1  A1000 (-4.0A)
DI1  A1000 (-3.7A)
1.38A16.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZV2_A_LEVA801_1
(FIBROBLAST GROWTH
FACTOR RECEPTOR 1)
4ckr EPITHELIAL DISCOIDIN
DOMAIN-CONTAINING
RECEPTOR 1
(Homo
sapiens)
8 / 12LEU A 616
PHE A 785
VAL A 624
ALA A 653
GLU A 672
MET A 676
TYR A 703
ALA A 783
None
DI1  A1000 (-4.5A)
DI1  A1000 (-4.8A)
DI1  A1000 (-3.6A)
DI1  A1000 (-3.8A)
DI1  A1000 (-3.6A)
DI1  A1000 (-4.0A)
DI1  A1000 (-3.7A)
0.99A16.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZV2_A_LEVA801_1
(FIBROBLAST GROWTH
FACTOR RECEPTOR 1)
4ckr EPITHELIAL DISCOIDIN
DOMAIN-CONTAINING
RECEPTOR 1
(Homo
sapiens)
8 / 12PHE A 785
VAL A 624
ALA A 653
GLU A 672
MET A 676
TYR A 703
GLY A 707
ALA A 783
DI1  A1000 (-4.5A)
DI1  A1000 (-4.8A)
DI1  A1000 (-3.6A)
DI1  A1000 (-3.8A)
DI1  A1000 (-3.6A)
DI1  A1000 (-4.0A)
None
DI1  A1000 (-3.7A)
0.97A16.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZV2_A_LEVA801_1
(FIBROBLAST GROWTH
FACTOR RECEPTOR 1)
4crs SERINE/THREONINE-PRO
TEIN KINASE N2
(Homo
sapiens)
8 / 12LEU A 663
VAL A 671
ALA A 684
GLU A 705
TYR A 739
ALA A 740
GLY A 743
ALA A 799
AGS  A1985 (-4.2A)
AGS  A1985 (-4.6A)
AGS  A1985 (-3.5A)
None
None
AGS  A1985 (-3.9A)
None
AGS  A1985 ( 4.5A)
0.64A11.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZV2_A_LEVA801_1
(FIBROBLAST GROWTH
FACTOR RECEPTOR 1)
4gv1 RAC-ALPHA
SERINE/THREONINE-PRO
TEIN KINASE
(Homo
sapiens)
7 / 12LEU A 156
VAL A 164
ALA A 177
GLU A 198
TYR A 229
ALA A 230
GLY A 233
0XZ  A 501 ( 4.1A)
0XZ  A 501 (-4.5A)
0XZ  A 501 (-3.3A)
GOL  A 503 (-3.6A)
0XZ  A 501 ( 4.9A)
0XZ  A 501 (-3.7A)
None
0.59A13.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZV2_A_LEVA801_1
(FIBROBLAST GROWTH
FACTOR RECEPTOR 1)
4hvi TYROSINE-PROTEIN
KINASE JAK3
(Homo
sapiens)
7 / 12LEU A 828
VAL A 836
ALA A 853
GLU A 871
TYR A 904
GLY A 908
ALA A 966
19S  A1201 (-3.9A)
19S  A1201 (-4.4A)
19S  A1201 (-3.3A)
None
19S  A1201 (-4.7A)
19S  A1201 ( 3.8A)
19S  A1201 ( 4.1A)
0.57A16.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZV2_A_LEVA801_1
(FIBROBLAST GROWTH
FACTOR RECEPTOR 1)
4k11 PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC
(Homo
sapiens)
6 / 12LEU A 273
VAL A 281
ALA A 293
TYR A 340
GLY A 344
ALA A 403
0J9  A 601 (-4.0A)
0J9  A 601 (-4.4A)
0J9  A 601 (-3.3A)
0J9  A 601 ( 4.7A)
0J9  A 601 ( 4.1A)
0J9  A 601 (-3.5A)
0.67A10.98
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5ZV2_A_LEVA801_1
(FIBROBLAST GROWTH
FACTOR RECEPTOR 1)
4k33 FIBROBLAST GROWTH
FACTOR RECEPTOR 3
(Homo
sapiens)
10 / 12LEU A 478
GLY A 479
ALA A 506
GLU A 525
MET A 529
VAL A 555
TYR A 557
ALA A 558
GLY A 561
ALA A 634
ACP  A 801 (-3.8A)
ACP  A 801 (-3.4A)
ACP  A 801 (-3.3A)
ACP  A 801 ( 4.8A)
None
ACP  A 801 (-4.7A)
None
ACP  A 801 (-3.7A)
ACP  A 801 ( 4.6A)
None
0.83A66.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5ZV2_A_LEVA801_1
(FIBROBLAST GROWTH
FACTOR RECEPTOR 1)
4k33 FIBROBLAST GROWTH
FACTOR RECEPTOR 3
(Homo
sapiens)
10 / 12LEU A 478
VAL A 486
ALA A 506
GLU A 525
MET A 529
VAL A 555
TYR A 557
ALA A 558
GLY A 561
ALA A 634
ACP  A 801 (-3.8A)
ACP  A 801 (-4.2A)
ACP  A 801 (-3.3A)
ACP  A 801 ( 4.8A)
None
ACP  A 801 (-4.7A)
None
ACP  A 801 (-3.7A)
ACP  A 801 ( 4.6A)
None
0.69A66.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZV2_A_LEVA801_1
(FIBROBLAST GROWTH
FACTOR RECEPTOR 1)
4l52 MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE KINASE 7,
TGF-BETA-ACTIVATED
KINASE 1 AND
MAP3K7-BINDING
PROTEIN 1 CHIMERA
(Homo
sapiens)
6 / 12VAL A  50
ALA A  61
GLU A  77
TYR A 106
ALA A 107
GLY A 110
1UL  A 501 ( 4.9A)
1UL  A 501 (-3.1A)
None
1UL  A 501 (-4.1A)
1UL  A 501 (-3.6A)
1UL  A 501 ( 3.7A)
0.67A13.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZV2_A_LEVA801_1
(FIBROBLAST GROWTH
FACTOR RECEPTOR 1)
4lg4 SERINE/THREONINE-PRO
TEIN KINASE 3
(Homo
sapiens)
6 / 12LEU A  33
VAL A  41
ALA A  54
MET A  74
TYR A 101
ALA A 163
GOL  A 404 ( 3.6A)
GOL  A 404 (-4.5A)
GOL  A 404 ( 3.1A)
None
GOL  A 404 ( 4.9A)
GOL  A 403 ( 3.0A)
0.70A15.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZV2_A_LEVA801_1
(FIBROBLAST GROWTH
FACTOR RECEPTOR 1)
4lg4 SERINE/THREONINE-PRO
TEIN KINASE 3
(Homo
sapiens)
6 / 12LEU A  33
VAL A  41
ALA A  54
TYR A 101
GLY A 105
ALA A 163
GOL  A 404 ( 3.6A)
GOL  A 404 (-4.5A)
GOL  A 404 ( 3.1A)
GOL  A 404 ( 4.9A)
GOL  A 404 (-3.6A)
GOL  A 403 ( 3.0A)
0.68A15.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZV2_A_LEVA801_1
(FIBROBLAST GROWTH
FACTOR RECEPTOR 1)
4o27 SERINE/THREONINE-PRO
TEIN KINASE 24
(Homo
sapiens)
6 / 12VAL B  38
ALA B  51
GLU B  70
TYR B 101
GLY B 105
ALA B 161
ADP  B 500 (-4.5A)
ADP  B 500 (-3.3A)
None
ADP  B 500 ( 4.7A)
None
None
0.53A13.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZV2_A_LEVA801_1
(FIBROBLAST GROWTH
FACTOR RECEPTOR 1)
4oli NON-RECEPTOR
TYROSINE-PROTEIN
KINASE TYK2
(Homo
sapiens)
6 / 12LEU A 903
VAL A 911
ALA A 928
GLU A 947
TYR A 980
GLY A 984
2TT  A1202 (-3.5A)
2TT  A1202 (-4.5A)
2TT  A1202 ( 3.9A)
None
2TT  A1202 (-4.6A)
2TT  A1202 (-3.4A)
0.69A7.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZV2_A_LEVA801_1
(FIBROBLAST GROWTH
FACTOR RECEPTOR 1)
4q9z HUMAN PROTEIN KINASE
C THETA
(Homo
sapiens)
7 / 12LEU A 386
VAL A 394
ALA A 407
GLU A 428
TYR A 460
GLY A 464
ALA A 521
PZW  A 801 (-3.9A)
PZW  A 801 (-4.6A)
PZW  A 801 (-3.5A)
None
None
None
PZW  A 801 ( 4.6A)
0.76A11.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZV2_A_LEVA801_1
(FIBROBLAST GROWTH
FACTOR RECEPTOR 1)
4rt7 RECEPTOR-TYPE
TYROSINE-PROTEIN
KINASE FLT3
(Homo
sapiens)
7 / 12LEU A 616
GLY A 617
PHE A 830
ALA A 642
GLU A 661
TYR A 693
GLY A 697
P30  A1001 (-3.8A)
None
P30  A1001 (-3.9A)
P30  A1001 (-3.4A)
P30  A1001 (-3.6A)
P30  A1001 (-4.1A)
P30  A1001 (-3.4A)
1.16A12.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZV2_A_LEVA801_1
(FIBROBLAST GROWTH
FACTOR RECEPTOR 1)
4rt7 RECEPTOR-TYPE
TYROSINE-PROTEIN
KINASE FLT3
(Homo
sapiens)
7 / 12LEU A 616
PHE A 830
VAL A 624
ALA A 642
GLU A 661
TYR A 693
GLY A 697
P30  A1001 (-3.8A)
P30  A1001 (-3.9A)
None
P30  A1001 (-3.4A)
P30  A1001 (-3.6A)
P30  A1001 (-4.1A)
P30  A1001 (-3.4A)
0.75A12.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZV2_A_LEVA801_1
(FIBROBLAST GROWTH
FACTOR RECEPTOR 1)
4wb7 DNAJ HOMOLOG
SUBFAMILY B MEMBER
1,CAMP-DEPENDENT
PROTEIN KINASE
CATALYTIC SUBUNIT
ALPHA
(Homo
sapiens)
6 / 12LEU A 104
VAL A 112
ALA A 125
GLU A 146
TYR A 177
GLY A 181
ATP  A 501 ( 4.3A)
ATP  A 501 (-4.0A)
ATP  A 501 (-3.4A)
None
None
None
0.50A14.37
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5ZV2_A_LEVA801_1
(FIBROBLAST GROWTH
FACTOR RECEPTOR 1)
4xcu FIBROBLAST GROWTH
FACTOR RECEPTOR 4
(Homo
sapiens)
8 / 12LEU A 473
GLY A 474
VAL A 481
ALA A 501
GLU A 520
MET A 524
VAL A 550
ALA A 629
40M  A1002 ( 4.6A)
None
40M  A1002 ( 4.5A)
40M  A1002 ( 4.1A)
40M  A1002 (-3.7A)
40M  A1002 (-3.8A)
40M  A1002 (-4.7A)
40M  A1002 (-3.0A)
1.00A65.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5ZV2_A_LEVA801_1
(FIBROBLAST GROWTH
FACTOR RECEPTOR 1)
4xcu FIBROBLAST GROWTH
FACTOR RECEPTOR 4
(Homo
sapiens)
9 / 12LEU A 473
VAL A 481
ALA A 501
GLU A 520
MET A 524
VAL A 550
ALA A 553
GLY A 556
ALA A 629
40M  A1002 ( 4.6A)
40M  A1002 ( 4.5A)
40M  A1002 ( 4.1A)
40M  A1002 (-3.7A)
40M  A1002 (-3.8A)
40M  A1002 (-4.7A)
40M  A1002 (-3.7A)
40M  A1002 ( 3.7A)
40M  A1002 (-3.0A)
0.52A65.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZV2_A_LEVA801_1
(FIBROBLAST GROWTH
FACTOR RECEPTOR 1)
4xey TYROSINE-PROTEIN
KINASE ABL1
(Homo
sapiens)
6 / 12LEU B 267
VAL B 275
ALA B 288
MET B 309
GLY B 340
ALA B 399
1N1  B 601 (-3.7A)
1N1  B 601 ( 4.9A)
1N1  B 601 (-3.5A)
1N1  B 601 (-3.7A)
1N1  B 601 (-3.5A)
1N1  B 601 (-3.5A)
0.77A13.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZV2_A_LEVA801_1
(FIBROBLAST GROWTH
FACTOR RECEPTOR 1)
4xuf RECEPTOR-TYPE
TYROSINE-PROTEIN
KINASE FLT3
(Homo
sapiens)
7 / 12GLY A 617
PHE A 830
VAL A 624
ALA A 642
GLU A 661
MET A 665
TYR A 693
None
P30  A1001 ( 4.1A)
P30  A1001 ( 4.8A)
P30  A1001 (-3.5A)
P30  A1001 (-3.1A)
P30  A1001 (-4.4A)
P30  A1001 ( 4.4A)
1.23A14.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZV2_A_LEVA801_1
(FIBROBLAST GROWTH
FACTOR RECEPTOR 1)
4xuf RECEPTOR-TYPE
TYROSINE-PROTEIN
KINASE FLT3
(Homo
sapiens)
7 / 12LEU A 616
GLY A 617
PHE A 830
VAL A 624
ALA A 642
GLU A 661
TYR A 693
P30  A1001 (-4.0A)
None
P30  A1001 ( 4.1A)
P30  A1001 ( 4.8A)
P30  A1001 (-3.5A)
P30  A1001 (-3.1A)
P30  A1001 ( 4.4A)
1.11A14.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZV2_A_LEVA801_1
(FIBROBLAST GROWTH
FACTOR RECEPTOR 1)
4xuf RECEPTOR-TYPE
TYROSINE-PROTEIN
KINASE FLT3
(Homo
sapiens)
7 / 12LEU A 616
PHE A 830
VAL A 624
ALA A 642
GLU A 661
TYR A 693
GLY A 697
P30  A1001 (-4.0A)
P30  A1001 ( 4.1A)
P30  A1001 ( 4.8A)
P30  A1001 (-3.5A)
P30  A1001 (-3.1A)
P30  A1001 ( 4.4A)
P30  A1001 (-3.5A)
0.80A14.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZV2_A_LEVA801_1
(FIBROBLAST GROWTH
FACTOR RECEPTOR 1)
4xuf RECEPTOR-TYPE
TYROSINE-PROTEIN
KINASE FLT3
(Homo
sapiens)
7 / 12PHE A 830
VAL A 624
ALA A 642
GLU A 661
MET A 665
TYR A 693
GLY A 697
P30  A1001 ( 4.1A)
P30  A1001 ( 4.8A)
P30  A1001 (-3.5A)
P30  A1001 (-3.1A)
P30  A1001 (-4.4A)
P30  A1001 ( 4.4A)
P30  A1001 (-3.5A)
0.90A14.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZV2_A_LEVA801_1
(FIBROBLAST GROWTH
FACTOR RECEPTOR 1)
4yff SERINE/THREONINE-PRO
TEIN KINASE TNNI3K
(Homo
sapiens)
6 / 12VAL A 477
ALA A 488
GLU A 509
TYR A 541
GLY A 545
ALA A 605
None
4CV  A 801 (-3.5A)
None
4CV  A 801 (-3.9A)
4CV  A 801 ( 4.0A)
4CV  A 801 ( 3.9A)
0.76A12.66
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5ZV2_A_LEVA801_1
(FIBROBLAST GROWTH
FACTOR RECEPTOR 1)
5a46 FIBROBLAST GROWTH
FACTOR RECEPTOR 1
(FMS-RELATED
TYROSINE KINASE 2,
PFEIFFER SYNDROME),
ISOFORM CRA_B
(Homo
sapiens)
9 / 12LEU A 484
GLY A 485
ALA A 512
GLU A 531
MET A 535
VAL A 561
TYR A 563
ALA A 564
ALA A 640
38O  A1769 (-3.2A)
38O  A1769 ( 4.7A)
38O  A1769 (-3.6A)
EDO  A1766 (-4.1A)
EDO  A1766 (-3.5A)
38O  A1769 (-4.3A)
38O  A1769 (-4.2A)
38O  A1769 (-3.9A)
EDO  A1766 ( 4.4A)
0.99A78.22
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5ZV2_A_LEVA801_1
(FIBROBLAST GROWTH
FACTOR RECEPTOR 1)
5a46 FIBROBLAST GROWTH
FACTOR RECEPTOR 1
(FMS-RELATED
TYROSINE KINASE 2,
PFEIFFER SYNDROME),
ISOFORM CRA_B
(Homo
sapiens)
10 / 12LEU A 484
VAL A 492
ALA A 512
GLU A 531
MET A 535
VAL A 561
TYR A 563
ALA A 564
GLY A 567
ALA A 640
38O  A1769 (-3.2A)
38O  A1769 (-4.5A)
38O  A1769 (-3.6A)
EDO  A1766 (-4.1A)
EDO  A1766 (-3.5A)
38O  A1769 (-4.3A)
38O  A1769 (-4.2A)
38O  A1769 (-3.9A)
38O  A1769 (-3.4A)
EDO  A1766 ( 4.4A)
0.42A78.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZV2_A_LEVA801_1
(FIBROBLAST GROWTH
FACTOR RECEPTOR 1)
5es1 MAP/MICROTUBULE
AFFINITY-REGULATING
KINASE 4
(Homo
sapiens)
7 / 12VAL A  70
ALA A  83
GLU A 103
TYR A 134
ALA A 135
GLY A 138
ALA A 195
5RC  A4000 (-4.6A)
5RC  A4000 (-3.6A)
None
5RC  A4000 (-4.5A)
5RC  A4000 (-3.7A)
5RC  A4000 (-3.3A)
5RC  A4000 ( 3.9A)
0.87A11.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZV2_A_LEVA801_1
(FIBROBLAST GROWTH
FACTOR RECEPTOR 1)
5f1z NON-RECEPTOR
TYROSINE-PROTEIN
KINASE TYK2
(Homo
sapiens)
6 / 12LEU A 903
VAL A 911
ALA A 928
GLU A 947
TYR A 980
GLY A 984
5U3  A1200 (-3.8A)
5U3  A1200 ( 4.4A)
5U3  A1200 (-3.5A)
None
5U3  A1200 (-4.5A)
5U3  A1200 (-3.2A)
0.55A15.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZV2_A_LEVA801_1
(FIBROBLAST GROWTH
FACTOR RECEPTOR 1)
5fm2 PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE RECEPTOR RET
(Homo
sapiens)
7 / 12LEU A 730
GLY A 731
ALA A 756
VAL A 804
TYR A 806
ALA A 807
GLY A 810
PP1  A2012 (-4.6A)
PP1  A2012 ( 3.9A)
PP1  A2012 (-3.2A)
PP1  A2012 (-4.5A)
None
PP1  A2012 ( 3.5A)
PTR  A 809 (-2.4A)
0.75A13.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZV2_A_LEVA801_1
(FIBROBLAST GROWTH
FACTOR RECEPTOR 1)
5fm2 PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE RECEPTOR RET
(Homo
sapiens)
6 / 12LEU A 730
VAL A 738
ALA A 756
GLU A 775
VAL A 804
TYR A 806
PP1  A2012 (-4.6A)
PP1  A2012 (-4.4A)
PP1  A2012 (-3.2A)
PP1  A2012 (-3.5A)
PP1  A2012 (-4.5A)
None
0.54A13.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZV2_A_LEVA801_1
(FIBROBLAST GROWTH
FACTOR RECEPTOR 1)
5fm2 PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE RECEPTOR RET
(Homo
sapiens)
7 / 12LEU A 730
VAL A 738
ALA A 756
VAL A 804
TYR A 806
ALA A 807
GLY A 810
PP1  A2012 (-4.6A)
PP1  A2012 (-4.4A)
PP1  A2012 (-3.2A)
PP1  A2012 (-4.5A)
None
PP1  A2012 ( 3.5A)
PTR  A 809 (-2.4A)
0.58A13.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZV2_A_LEVA801_1
(FIBROBLAST GROWTH
FACTOR RECEPTOR 1)
5grn PLATELET-DERIVED
GROWTH FACTOR
RECEPTOR ALPHA
(Homo
sapiens)
7 / 12LEU A 599
VAL A 607
ALA A 625
GLU A 644
MET A 648
TYR A 676
GLY A 680
748  A1001 (-3.8A)
748  A1001 ( 4.7A)
748  A1001 (-3.7A)
748  A1001 (-3.3A)
748  A1001 (-3.4A)
748  A1001 (-4.0A)
748  A1001 ( 4.0A)
0.64A17.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZV2_A_LEVA801_1
(FIBROBLAST GROWTH
FACTOR RECEPTOR 1)
5grn PLATELET-DERIVED
GROWTH FACTOR
RECEPTOR ALPHA
(Homo
sapiens)
7 / 12PHE A 837
VAL A 607
ALA A 625
GLU A 644
MET A 648
TYR A 676
GLY A 680
748  A1001 (-3.7A)
748  A1001 ( 4.7A)
748  A1001 (-3.7A)
748  A1001 (-3.3A)
748  A1001 (-3.4A)
748  A1001 (-4.0A)
748  A1001 ( 4.0A)
0.95A17.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZV2_A_LEVA801_2
(FIBROBLAST GROWTH
FACTOR RECEPTOR 1)
1ak6 DESTRIN
(Homo
sapiens;
Sus
scrofa)
3 / 3LYS A 112
LEU A 108
ASP A  79
None
0.87A19.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZV2_A_LEVA801_2
(FIBROBLAST GROWTH
FACTOR RECEPTOR 1)
1hjv CHITINASE-3 LIKE
PROTEIN 1
(Homo
sapiens)
3 / 3LYS A 377
LEU A 354
ASP A  47
None
0.82A11.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZV2_A_LEVA801_2
(FIBROBLAST GROWTH
FACTOR RECEPTOR 1)
1zrz PROTEIN KINASE C,
IOTA
(Homo
sapiens)
3 / 3LYS A 274
LEU A 376
ASP A 387
BI1  A1000 (-3.5A)
BI1  A1000 (-4.8A)
BI1  A1000 (-4.5A)
0.93A13.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZV2_A_LEVA801_2
(FIBROBLAST GROWTH
FACTOR RECEPTOR 1)
2buj SERINE/THREONINE-PRO
TEIN KINASE 16
(Homo
sapiens)
3 / 3LYS A  49
LEU A 155
ASP A 166
STU  A1301 ( 4.0A)
STU  A1301 ( 4.8A)
None
0.90A13.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZV2_A_LEVA801_2
(FIBROBLAST GROWTH
FACTOR RECEPTOR 1)
2dh3 4F2 CELL-SURFACE
ANTIGEN HEAVY CHAIN
(Homo
sapiens)
3 / 3LYS A 116
LEU A 298
ASP A 296
None
0.76A11.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZV2_A_LEVA801_2
(FIBROBLAST GROWTH
FACTOR RECEPTOR 1)
2vd5 DMPK PROTEIN
(Homo
sapiens)
3 / 3LYS A 100
LEU A 202
ASP A 213
BI8  A1417 (-4.2A)
BI8  A1417 (-4.8A)
BI8  A1417 (-3.8A)
0.94A11.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZV2_A_LEVA801_2
(FIBROBLAST GROWTH
FACTOR RECEPTOR 1)
2wnp FICOLIN-1
(Homo
sapiens)
3 / 3LYS F 230
LEU F 262
ASP F 138
None
0.71A15.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZV2_A_LEVA801_2
(FIBROBLAST GROWTH
FACTOR RECEPTOR 1)
2xik SERINE/THREONINE
PROTEIN KINASE 25
(Homo
sapiens)
3 / 3LYS A  49
LEU A 147
ASP A 158
None
J60  A1294 (-4.8A)
J60  A1294 ( 4.6A)
0.69A14.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZV2_A_LEVA801_2
(FIBROBLAST GROWTH
FACTOR RECEPTOR 1)
2xsx BETA-ENOLASE
(Homo
sapiens)
3 / 3LYS A 120
LEU A 112
ASP A 378
None
None
EDO  A 511 (-4.3A)
0.86A11.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZV2_A_LEVA801_2
(FIBROBLAST GROWTH
FACTOR RECEPTOR 1)
2y7j PHOSPHORYLASE B
KINASE GAMMA
CATALYTIC CHAIN,
TESTIS/LIVER ISOFORM
(Homo
sapiens)
3 / 3LYS A  53
LEU A 160
ASP A 171
None
B49  A1294 (-4.4A)
B49  A1294 (-4.2A)
0.67A12.15
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5ZV2_A_LEVA801_2
(FIBROBLAST GROWTH
FACTOR RECEPTOR 1)
3c4f BASIC FIBROBLAST
GROWTH FACTOR
RECEPTOR 1
(Homo
sapiens)
3 / 3LYS A 514
LEU A 630
ASP A 641
None
C4F  A   1 (-4.6A)
C4F  A   1 (-4.5A)
0.72A100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZV2_A_LEVA801_2
(FIBROBLAST GROWTH
FACTOR RECEPTOR 1)
3iec SERINE/THREONINE-PRO
TEIN KINASE MARK2
(Homo
sapiens)
3 / 3LYS A  82
LEU A 182
ASP A 193
None
0.84A13.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZV2_A_LEVA801_2
(FIBROBLAST GROWTH
FACTOR RECEPTOR 1)
3lm5 SERINE/THREONINE-PRO
TEIN KINASE 17B
(Homo
sapiens)
3 / 3LYS A  62
LEU A 165
ASP A 179
QUE  A   1 (-4.1A)
None
QUE  A   1 (-2.9A)
0.82A12.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZV2_A_LEVA801_2
(FIBROBLAST GROWTH
FACTOR RECEPTOR 1)
3s95 LIM DOMAIN KINASE 1
(Homo
sapiens)
3 / 3LYS A 368
LEU A 467
ASP A 478
STU  A   1 (-3.1A)
STU  A   1 (-4.6A)
STU  A   1 ( 4.2A)
0.76A14.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZV2_A_LEVA801_2
(FIBROBLAST GROWTH
FACTOR RECEPTOR 1)
3sag EXOSOME COMPONENT 10
(Homo
sapiens)
3 / 3LYS A 480
LEU A 216
ASP A 252
LYS  A 480 ( 0.0A)
LEU  A 216 ( 0.6A)
ASP  A 252 ( 0.6A)
0.84A12.02
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5ZV2_A_LEVA801_2
(FIBROBLAST GROWTH
FACTOR RECEPTOR 1)
3tt0 BASIC FIBROBLAST
GROWTH FACTOR
RECEPTOR 1
(Homo
sapiens)
3 / 3LYS A 514
LEU A 630
ASP A 641
07J  A   1 (-4.5A)
07J  A   1 ( 4.4A)
07J  A   1 (-4.7A)
0.58A59.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZV2_A_LEVA801_2
(FIBROBLAST GROWTH
FACTOR RECEPTOR 1)
3wzd VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 2
(Homo
sapiens)
3 / 3LYS A 868
LEU A1035
ASP A1046
None
LEV  A1201 (-4.8A)
GOL  A1210 ( 3.4A)
0.42A16.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZV2_A_LEVA801_2
(FIBROBLAST GROWTH
FACTOR RECEPTOR 1)
3zbf PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ROS
(Homo
sapiens)
3 / 3LYS A1980
LEU A2086
ASP A2102
VGH  A3000 ( 4.7A)
VGH  A3000 (-4.3A)
None
0.89A16.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZV2_A_LEVA801_2
(FIBROBLAST GROWTH
FACTOR RECEPTOR 1)
4at3 BDNF/NT-3 GROWTH
FACTORS RECEPTOR
(Homo
sapiens)
3 / 3LYS A 588
LEU A 699
ASP A 710
None
LTI  A1839 (-4.2A)
None
0.85A12.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZV2_A_LEVA801_2
(FIBROBLAST GROWTH
FACTOR RECEPTOR 1)
4aw5 EPHRIN TYPE-B
RECEPTOR 4
(Homo
sapiens)
3 / 3LYS A 123
LEU A 223
ASP A 234
30K  A1365 (-3.8A)
30K  A1365 (-4.5A)
30K  A1365 (-3.3A)
0.81A14.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZV2_A_LEVA801_2
(FIBROBLAST GROWTH
FACTOR RECEPTOR 1)
4bgq CYCLIN-DEPENDENT
KINASE-LIKE 5
(Homo
sapiens)
3 / 3LYS A  42
LEU A 142
ASP A 153
38R  A1000 (-3.4A)
38R  A1000 ( 4.5A)
38R  A1000 ( 4.2A)
0.80A11.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZV2_A_LEVA801_2
(FIBROBLAST GROWTH
FACTOR RECEPTOR 1)
4ks8 SERINE/THREONINE-PRO
TEIN KINASE PAK 6
(Homo
sapiens)
3 / 3LYS A 436
LEU A 533
ASP A 544
None
B49  A 701 (-4.5A)
B49  A 701 (-4.6A)
0.80A15.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZV2_A_LEVA801_2
(FIBROBLAST GROWTH
FACTOR RECEPTOR 1)
4o27 SERINE/THREONINE-PRO
TEIN KINASE 24
(Homo
sapiens)
3 / 3LYS B  53
LEU B 151
ASP B 162
ADP  B 500 (-3.1A)
ADP  B 500 (-4.7A)
ADP  B 500 ( 3.4A)
0.94A13.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZV2_A_LEVA801_2
(FIBROBLAST GROWTH
FACTOR RECEPTOR 1)
4xbr PROTEIN
FAM212A,SERINE/THREO
NINE-PROTEIN KINASE
PAK 4
(Homo
sapiens)
3 / 3LYS A 350
LEU A 447
ASP A 458
ATP  A 601 (-2.8A)
None
ATP  A 601 ( 2.5A)
0.84A16.61
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5ZV2_A_LEVA801_2
(FIBROBLAST GROWTH
FACTOR RECEPTOR 1)
4xcu FIBROBLAST GROWTH
FACTOR RECEPTOR 4
(Homo
sapiens)
3 / 3LYS A 503
LEU A 619
ASP A 630
40M  A1002 (-4.0A)
40M  A1002 (-4.5A)
40M  A1002 (-4.5A)
0.60A65.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZV2_A_LEVA801_2
(FIBROBLAST GROWTH
FACTOR RECEPTOR 1)
5j9z EPIDERMAL GROWTH
FACTOR RECEPTOR
(Homo
sapiens)
3 / 3LYS A 745
LEU A 844
ASP A 855
6HJ  A1101 (-4.2A)
6HJ  A1101 ( 4.8A)
6HJ  A1101 (-4.3A)
0.69A14.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZV2_A_LEVA801_2
(FIBROBLAST GROWTH
FACTOR RECEPTOR 1)
5mov CASEIN KINASE II
SUBUNIT ALPHA
(Homo
sapiens)
3 / 3LYS A  77
LEU A  85
ASP A 175
None
None
HC4  A 401 (-4.0A)
0.89A12.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZV2_A_LEVA801_2
(FIBROBLAST GROWTH
FACTOR RECEPTOR 1)
5okt CASEIN KINASE I
ISOFORM DELTA
(Homo
sapiens)
3 / 3LYS C  38
LEU C 135
ASP C 149
9XK  C 301 ( 4.6A)
9XK  C 301 (-4.6A)
None
0.85A29.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZV2_A_LEVA801_2
(FIBROBLAST GROWTH
FACTOR RECEPTOR 1)
5tvt MATERNAL EMBRYONIC
LEUCINE ZIPPER
KINASE
(Homo
sapiens)
3 / 3LYS A  40
LEU A 139
ASP A 150
7LV  A 401 (-3.0A)
7LV  A 401 (-4.9A)
7LV  A 401 (-4.2A)
0.86A14.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZV2_A_LEVA801_2
(FIBROBLAST GROWTH
FACTOR RECEPTOR 1)
5uuu BETA-ADRENERGIC
RECEPTOR KINASE 1
(Homo
sapiens)
3 / 3LYS A 170
LEU A  34
ASP A 534
None
0.91A9.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZV2_A_LEVA801_2
(FIBROBLAST GROWTH
FACTOR RECEPTOR 1)
5w7i PALMITOYLTRANSFERASE
ZDHHC17
(Homo
sapiens)
3 / 3LYS A 266
LEU A 229
ASP A 252
None
0.90A18.70
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5ZV2_A_LEVA801_2
(FIBROBLAST GROWTH
FACTOR RECEPTOR 1)
6f3d INTERLEUKIN-1
RECEPTOR-ASSOCIATED
KINASE 4
(Homo
sapiens)
3 / 3LYS A 213
LEU A 318
ASP A 329
CJT  A 502 (-3.0A)
CJT  A 502 (-4.7A)
CJT  A 502 ( 4.0A)
0.73A34.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZV2_B_LEVB801_1
(FIBROBLAST GROWTH
FACTOR RECEPTOR 1)
1rjb FL CYTOKINE RECEPTOR
(Homo
sapiens)
7 / 12LEU A 616
GLY A 617
VAL A 624
ALA A 642
LYS A 644
GLU A 661
GLY A 697
None
1.01A15.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZV2_B_LEVB801_1
(FIBROBLAST GROWTH
FACTOR RECEPTOR 1)
1t46 HOMO SAPIENS V-KIT
HARDY-ZUCKERMAN 4
FELINE SARCOMA VIRAL
ONCOGENE HOMOLOG
(Homo
sapiens)
6 / 12LEU A 595
VAL A 603
ALA A 621
LYS A 623
GLU A 640
GLY A 676
STI  A   3 ( 3.8A)
STI  A   3 ( 4.6A)
STI  A   3 (-3.5A)
STI  A   3 (-3.7A)
STI  A   3 (-3.6A)
STI  A   3 ( 3.8A)
0.48A18.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZV2_B_LEVB801_1
(FIBROBLAST GROWTH
FACTOR RECEPTOR 1)
1u59 TYROSINE-PROTEIN
KINASE ZAP-70
(Homo
sapiens)
8 / 12LEU A 344
VAL A 352
ALA A 367
LYS A 369
GLU A 386
MET A 390
ALA A 417
GLY A 420
STU  A 100 (-3.8A)
STU  A 100 (-4.8A)
STU  A 100 (-3.2A)
STU  A 100 ( 4.7A)
None
None
STU  A 100 (-3.7A)
STU  A 100 (-3.5A)
0.68A15.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZV2_B_LEVB801_1
(FIBROBLAST GROWTH
FACTOR RECEPTOR 1)
1zlt SERINE/THREONINE-PRO
TEIN KINASE CHK1
(Homo
sapiens)
6 / 12LEU A  15
VAL A  23
ALA A  36
LYS A  38
GLU A  55
GLY A  90
HYM  A 400 (-4.2A)
HYM  A 400 (-4.3A)
HYM  A 400 (-3.5A)
HYM  A 400 (-3.2A)
None
None
0.49A22.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZV2_B_LEVB801_1
(FIBROBLAST GROWTH
FACTOR RECEPTOR 1)
2a2a DEATH-ASSOCIATED
PROTEIN KINASE 2
(Homo
sapiens)
6 / 12LEU A  19
VAL A  27
ALA A  40
LYS A  42
GLU A  64
GLY A  99
None
None
GOL  A3001 (-3.5A)
None
None
None
0.58A12.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZV2_B_LEVB801_1
(FIBROBLAST GROWTH
FACTOR RECEPTOR 1)
2buj SERINE/THREONINE-PRO
TEIN KINASE 16
(Homo
sapiens)
6 / 12LEU A  26
VAL A  34
ALA A  47
LYS A  49
GLU A  65
GLY A 104
STU  A1301 (-4.2A)
STU  A1301 (-4.8A)
STU  A1301 (-3.6A)
STU  A1301 ( 4.0A)
None
STU  A1301 ( 4.0A)
0.68A13.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZV2_B_LEVB801_1
(FIBROBLAST GROWTH
FACTOR RECEPTOR 1)
2dq7 PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE FYN
(Homo
sapiens)
8 / 12LEU X  17
VAL X  25
ALA X  37
LYS X  39
GLU X  54
MET X  58
GLY X  88
ALA X 147
STU  X 902 (-3.8A)
STU  X 902 ( 4.8A)
STU  X 902 (-3.1A)
STU  X 902 (-3.1A)
STU  X 902 ( 4.4A)
None
STU  X 902 (-3.5A)
STU  X 902 ( 4.1A)
0.63A16.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZV2_B_LEVB801_1
(FIBROBLAST GROWTH
FACTOR RECEPTOR 1)
2eu9 DUAL SPECIFICITY
PROTEIN KINASE CLK3
(Homo
sapiens)
7 / 12LEU A 162
VAL A 170
ALA A 184
LYS A 186
GLU A 201
GLY A 240
ALA A 319
None
0.86A12.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZV2_B_LEVB801_1
(FIBROBLAST GROWTH
FACTOR RECEPTOR 1)
2hak SERINE/THREONINE-PRO
TEIN KINASE MARK1
(Homo
sapiens)
7 / 12VAL A  67
ALA A  80
LYS A  82
MET A 104
ALA A 132
GLY A 135
ALA A 192
None
1.01A14.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZV2_B_LEVB801_1
(FIBROBLAST GROWTH
FACTOR RECEPTOR 1)
2hk5 TYROSINE-PROTEIN
KINASE HCK
(Homo
sapiens)
6 / 12LEU A 251
VAL A 259
ALA A 271
LYS A 273
GLU A 288
MET A 292
1BM  A 499 ( 3.7A)
1BM  A 499 ( 4.8A)
1BM  A 499 (-3.6A)
1BM  A 499 (-3.8A)
1BM  A 499 (-3.2A)
1BM  A 499 ( 3.8A)
0.73A15.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZV2_B_LEVB801_1
(FIBROBLAST GROWTH
FACTOR RECEPTOR 1)
2hz0 PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1
(Homo
sapiens)
7 / 12LEU A 248
VAL A 256
ALA A 269
GLU A 286
MET A 290
GLY A 321
ALA A 380
GIN  A 600 ( 4.6A)
GIN  A 600 ( 4.7A)
GIN  A 600 (-3.1A)
GIN  A 600 (-3.6A)
GIN  A 600 (-3.2A)
None
GIN  A 600 (-3.1A)
0.65A16.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZV2_B_LEVB801_1
(FIBROBLAST GROWTH
FACTOR RECEPTOR 1)
2hz0 PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1
(Homo
sapiens)
7 / 12LEU A 248
VAL A 256
ALA A 269
LYS A 271
GLU A 286
GLY A 321
ALA A 380
GIN  A 600 ( 4.6A)
GIN  A 600 ( 4.7A)
GIN  A 600 (-3.1A)
GIN  A 600 (-3.6A)
GIN  A 600 (-3.6A)
None
GIN  A 600 (-3.1A)
0.54A16.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZV2_B_LEVB801_1
(FIBROBLAST GROWTH
FACTOR RECEPTOR 1)
2og8 PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE LCK
(Homo
sapiens)
9 / 12LEU A 251
PHE A 383
VAL A 259
ALA A 271
LYS A 273
GLU A 288
MET A 292
GLY A 322
ALA A 381
None
1N8  A 501 ( 4.3A)
None
1N8  A 501 ( 3.4A)
1N8  A 501 ( 3.4A)
1N8  A 501 ( 3.6A)
1N8  A 501 ( 3.6A)
1N8  A 501 ( 3.5A)
1N8  A 501 ( 3.3A)
0.88A20.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZV2_B_LEVB801_1
(FIBROBLAST GROWTH
FACTOR RECEPTOR 1)
2ogv MACROPHAGE
COLONY-STIMULATING
FACTOR 1 RECEPTOR
PRECURSOR
(Homo
sapiens)
6 / 12LEU A 588
VAL A 596
ALA A 614
GLU A 633
MET A 637
GLY A 669
None
0.57A24.49
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5ZV2_B_LEVB801_1
(FIBROBLAST GROWTH
FACTOR RECEPTOR 1)
2psq FIBROBLAST GROWTH
FACTOR RECEPTOR 2
(Homo
sapiens)
10 / 12LEU A 487
GLY A 488
VAL A 495
ALA A 515
GLU A 534
MET A 538
VAL A 564
ALA A 567
GLY A 570
ALA A 643
None
0.62A45.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZV2_B_LEVB801_1
(FIBROBLAST GROWTH
FACTOR RECEPTOR 1)
2w4k DEATH-ASSOCIATED
PROTEIN KINASE 1
(Homo
sapiens)
6 / 12LEU A  19
VAL A  27
ALA A  40
LYS A  42
GLU A  64
GLY A  99
ADP  A1303 ( 3.9A)
ADP  A1303 (-4.0A)
ADP  A1303 (-3.5A)
ADP  A1303 (-2.7A)
ADP  A1303 ( 4.8A)
None
0.50A16.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZV2_B_LEVB801_1
(FIBROBLAST GROWTH
FACTOR RECEPTOR 1)
2z8c INSULIN RECEPTOR
(Homo
sapiens)
6 / 12LEU A1002
VAL A1010
ALA A1028
LYS A1030
GLU A1047
MET A1051
S91  A   1 ( 4.1A)
S91  A   1 ( 4.9A)
S91  A   1 (-3.2A)
S91  A   1 ( 4.2A)
None
None
0.67A13.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZV2_B_LEVB801_1
(FIBROBLAST GROWTH
FACTOR RECEPTOR 1)
3a62 RIBOSOMAL PROTEIN S6
KINASE BETA-1
(Homo
sapiens)
6 / 12LEU A  97
VAL A 105
ALA A 121
LYS A 123
GLU A 143
GLY A 178
STU  A 400 (-3.8A)
STU  A 400 (-4.9A)
STU  A 400 (-3.1A)
STU  A 400 ( 4.3A)
STU  A 400 ( 4.3A)
STU  A 400 ( 4.4A)
0.63A13.21
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5ZV2_B_LEVB801_1
(FIBROBLAST GROWTH
FACTOR RECEPTOR 1)
3b2t FIBROBLAST GROWTH
FACTOR RECEPTOR 2
(Homo
sapiens)
7 / 12LEU A 487
GLY A 488
VAL A 495
ALA A 515
GLU A 534
MET A 538
VAL A 564
M33  A1996 (-4.0A)
M33  A1996 ( 3.8A)
M33  A1996 ( 4.7A)
M33  A1996 (-3.3A)
None
None
None
1.07A75.29
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5ZV2_B_LEVB801_1
(FIBROBLAST GROWTH
FACTOR RECEPTOR 1)
3b2t FIBROBLAST GROWTH
FACTOR RECEPTOR 2
(Homo
sapiens)
8 / 12LEU A 487
GLY A 488
VAL A 495
ALA A 515
MET A 538
VAL A 564
ALA A 567
ALA A 643
M33  A1996 (-4.0A)
M33  A1996 ( 3.8A)
M33  A1996 ( 4.7A)
M33  A1996 (-3.3A)
None
None
M33  A1996 (-3.8A)
None
0.94A75.29
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5ZV2_B_LEVB801_1
(FIBROBLAST GROWTH
FACTOR RECEPTOR 1)
3b2t FIBROBLAST GROWTH
FACTOR RECEPTOR 2
(Homo
sapiens)
7 / 12LEU A 487
VAL A 495
ALA A 515
LYS A 517
GLU A 534
MET A 538
VAL A 564
M33  A1996 (-4.0A)
M33  A1996 ( 4.7A)
M33  A1996 (-3.3A)
M33  A1996 ( 4.5A)
None
None
None
0.80A75.29
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5ZV2_B_LEVB801_1
(FIBROBLAST GROWTH
FACTOR RECEPTOR 1)
3b2t FIBROBLAST GROWTH
FACTOR RECEPTOR 2
(Homo
sapiens)
9 / 12LEU A 487
VAL A 495
ALA A 515
LYS A 517
MET A 538
VAL A 564
ALA A 567
GLY A 570
ALA A 643
M33  A1996 (-4.0A)
M33  A1996 ( 4.7A)
M33  A1996 (-3.3A)
M33  A1996 ( 4.5A)
None
None
M33  A1996 (-3.8A)
M33  A1996 ( 4.8A)
None
0.67A75.29
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5ZV2_B_LEVB801_1
(FIBROBLAST GROWTH
FACTOR RECEPTOR 1)
3c4f BASIC FIBROBLAST
GROWTH FACTOR
RECEPTOR 1
(Homo
sapiens)
7 / 12GLY A 487
PHE A 489
VAL A 492
ALA A 512
MET A 535
VAL A 561
ALA A 640
None
C4F  A   1 (-3.7A)
None
C4F  A   1 (-3.3A)
C4F  A   1 ( 3.7A)
C4F  A   1 ( 4.8A)
C4F  A   1 (-3.6A)
1.37A100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5ZV2_B_LEVB801_1
(FIBROBLAST GROWTH
FACTOR RECEPTOR 1)
3c4f BASIC FIBROBLAST
GROWTH FACTOR
RECEPTOR 1
(Homo
sapiens)
11 / 12LEU A 484
GLY A 485
PHE A 489
VAL A 492
ALA A 512
GLU A 531
MET A 535
VAL A 561
ALA A 564
GLY A 567
ALA A 640
C4F  A   1 ( 3.9A)
C4F  A   1 ( 4.5A)
C4F  A   1 (-3.7A)
None
C4F  A   1 (-3.3A)
None
C4F  A   1 ( 3.7A)
C4F  A   1 ( 4.8A)
C4F  A   1 (-3.5A)
None
C4F  A   1 (-3.6A)
0.61A100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5ZV2_B_LEVB801_1
(FIBROBLAST GROWTH
FACTOR RECEPTOR 1)
3c4f BASIC FIBROBLAST
GROWTH FACTOR
RECEPTOR 1
(Homo
sapiens)
11 / 12LEU A 484
GLY A 485
PHE A 489
VAL A 492
ALA A 512
LYS A 514
GLU A 531
MET A 535
VAL A 561
ALA A 564
GLY A 567
C4F  A   1 ( 3.9A)
C4F  A   1 ( 4.5A)
C4F  A   1 (-3.7A)
None
C4F  A   1 (-3.3A)
None
None
C4F  A   1 ( 3.7A)
C4F  A   1 ( 4.8A)
C4F  A   1 (-3.5A)
None
0.79A100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZV2_B_LEVB801_1
(FIBROBLAST GROWTH
FACTOR RECEPTOR 1)
3d7u TYROSINE-PROTEIN
KINASE CSK
(Homo
sapiens)
6 / 12VAL A 209
ALA A 220
LYS A 222
GLU A 236
MET A 240
GLY A 272
None
0.62A15.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZV2_B_LEVB801_1
(FIBROBLAST GROWTH
FACTOR RECEPTOR 1)
3fe3 MAP/MICROTUBULE
AFFINITY-REGULATING
KINASE 3
(Homo
sapiens)
7 / 12VAL A  70
ALA A  83
LYS A  85
MET A 107
ALA A 135
GLY A 138
ALA A 195
None
0.88A11.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZV2_B_LEVB801_1
(FIBROBLAST GROWTH
FACTOR RECEPTOR 1)
3hng VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 1
(Homo
sapiens)
7 / 12LEU A 833
VAL A 841
ALA A 859
LYS A 861
GLU A 878
VAL A 909
GLY A 915
8ST  A2001 ( 4.7A)
8ST  A2001 ( 4.6A)
8ST  A2001 ( 3.8A)
8ST  A2001 (-4.0A)
8ST  A2001 (-3.7A)
8ST  A2001 (-4.1A)
None
0.31A14.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZV2_B_LEVB801_1
(FIBROBLAST GROWTH
FACTOR RECEPTOR 1)
3iec SERINE/THREONINE-PRO
TEIN KINASE MARK2
(Homo
sapiens)
7 / 12VAL A  67
ALA A  80
LYS A  82
MET A 104
ALA A 132
GLY A 135
ALA A 192
None
0.71A13.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZV2_B_LEVB801_1
(FIBROBLAST GROWTH
FACTOR RECEPTOR 1)
3lm5 SERINE/THREONINE-PRO
TEIN KINASE 17B
(Homo
sapiens)
6 / 12LEU A  39
VAL A  47
ALA A  60
GLU A  80
ALA A 113
GLY A 116
QUE  A   1 ( 3.8A)
QUE  A   1 ( 4.6A)
QUE  A   1 (-3.2A)
QUE  A   1 (-3.1A)
QUE  A   1 (-3.9A)
None
0.63A12.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZV2_B_LEVB801_1
(FIBROBLAST GROWTH
FACTOR RECEPTOR 1)
3lm5 SERINE/THREONINE-PRO
TEIN KINASE 17B
(Homo
sapiens)
6 / 12LEU A  39
VAL A  47
ALA A  60
LYS A  62
ALA A 113
GLY A 116
QUE  A   1 ( 3.8A)
QUE  A   1 ( 4.6A)
QUE  A   1 (-3.2A)
QUE  A   1 (-4.1A)
QUE  A   1 (-3.9A)
None
0.58A12.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZV2_B_LEVB801_1
(FIBROBLAST GROWTH
FACTOR RECEPTOR 1)
3mvj CAMP-DEPENDENT
PROTEIN KINASE
CATALYTIC SUBUNIT
ALPHA
(Homo
sapiens)
6 / 12LEU A  49
VAL A  57
ALA A  70
LYS A  72
GLU A  91
GLY A 126
XFE  A 351 (-4.2A)
XFE  A 351 ( 4.5A)
XFE  A 351 (-3.2A)
None
None
None
0.36A15.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZV2_B_LEVB801_1
(FIBROBLAST GROWTH
FACTOR RECEPTOR 1)
3nuu PKB-LIKE
(Homo
sapiens)
7 / 12LEU A  88
VAL A  96
ALA A 109
GLU A 130
MET A 134
ALA A 162
GLY A 165
JOZ  A 361 (-4.1A)
JOZ  A 361 ( 4.7A)
JOZ  A 361 (-3.4A)
SO4  A   5 (-3.1A)
None
JOZ  A 361 (-3.8A)
None
0.57A15.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZV2_B_LEVB801_1
(FIBROBLAST GROWTH
FACTOR RECEPTOR 1)
3nuu PKB-LIKE
(Homo
sapiens)
7 / 12LEU A  88
VAL A  96
ALA A 109
LYS A 111
GLU A 130
ALA A 162
GLY A 165
JOZ  A 361 (-4.1A)
JOZ  A 361 ( 4.7A)
JOZ  A 361 (-3.4A)
SO4  A   5 (-2.8A)
SO4  A   5 (-3.1A)
JOZ  A 361 (-3.8A)
None
0.46A15.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZV2_B_LEVB801_1
(FIBROBLAST GROWTH
FACTOR RECEPTOR 1)
3nyo G PROTEIN-COUPLED
RECEPTOR KINASE 6
(Homo
sapiens)
6 / 12LEU A 192
VAL A 200
ALA A 213
LYS A 215
GLU A 234
GLY A 269
AMP  A 577 ( 4.3A)
AMP  A 577 (-4.3A)
AMP  A 577 (-3.4A)
AMP  A 577 (-2.8A)
None
None
0.71A10.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZV2_B_LEVB801_1
(FIBROBLAST GROWTH
FACTOR RECEPTOR 1)
3qfv CDC42BPB PROTEIN
(Homo
sapiens)
6 / 12VAL A  90
ALA A 103
LYS A 105
GLU A 124
GLY A 159
ALA A 217
NM7  A 416 (-3.7A)
NM7  A 416 ( 3.7A)
EDO  A 417 (-3.5A)
EDO  A 417 (-4.0A)
None
NM7  A 416 ( 4.5A)
0.66A13.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZV2_B_LEVB801_1
(FIBROBLAST GROWTH
FACTOR RECEPTOR 1)
3she MAP KINASE-ACTIVATED
PROTEIN KINASE 3
(Homo
sapiens)
6 / 12LEU A  50
VAL A  58
ALA A  71
LYS A  73
GLU A  84
GLY A 124
I85  A 350 (-3.7A)
I85  A 350 (-4.9A)
I85  A 350 (-3.3A)
I85  A 350 (-2.8A)
None
I85  A 350 (-3.0A)
0.65A11.67
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5ZV2_B_LEVB801_1
(FIBROBLAST GROWTH
FACTOR RECEPTOR 1)
3tt0 BASIC FIBROBLAST
GROWTH FACTOR
RECEPTOR 1
(Homo
sapiens)
10 / 12LEU A 484
VAL A 492
ALA A 512
LYS A 514
GLU A 531
MET A 535
VAL A 561
ALA A 564
GLY A 567
ALA A 640
07J  A   1 ( 4.3A)
07J  A   1 (-4.0A)
07J  A   1 (-3.5A)
07J  A   1 (-4.5A)
07J  A   1 (-3.8A)
07J  A   1 (-3.8A)
07J  A   1 (-4.7A)
07J  A   1 (-3.8A)
07J  A   1 (-3.7A)
07J  A   1 (-3.2A)
0.37A59.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZV2_B_LEVB801_1
(FIBROBLAST GROWTH
FACTOR RECEPTOR 1)
3txo PROTEIN KINASE C ETA
TYPE
(Homo
sapiens)
7 / 12LEU A 361
VAL A 369
ALA A 382
LYS A 384
GLU A 403
GLY A 439
ALA A 496
07U  A   1 ( 4.8A)
07U  A   1 (-4.8A)
07U  A   1 (-3.3A)
07U  A   1 (-3.0A)
07U  A   1 ( 4.8A)
None
07U  A   1 ( 4.0A)
0.70A11.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZV2_B_LEVB801_1
(FIBROBLAST GROWTH
FACTOR RECEPTOR 1)
3vid VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 2
(Homo
sapiens)
7 / 12LEU A 840
VAL A 848
ALA A 866
LYS A 868
GLU A 885
VAL A 916
GLY A 922
4TT  A2001 ( 4.0A)
4TT  A2001 ( 4.5A)
4TT  A2001 (-3.5A)
None
None
None
4TT  A2001 (-3.7A)
0.41A15.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZV2_B_LEVB801_1
(FIBROBLAST GROWTH
FACTOR RECEPTOR 1)
3w18 AURORA KINASE A
(Homo
sapiens)
7 / 12LEU A 139
VAL A 147
ALA A 160
LYS A 162
ALA A 213
GLY A 216
ALA A 273
N13  A 501 (-3.7A)
N13  A 501 ( 4.7A)
N13  A 501 ( 4.1A)
N13  A 501 (-2.9A)
N13  A 501 (-3.7A)
N13  A 501 (-3.5A)
N13  A 501 ( 3.8A)
0.66A13.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZV2_B_LEVB801_1
(FIBROBLAST GROWTH
FACTOR RECEPTOR 1)
3wzd VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 2
(Homo
sapiens)
8 / 12LEU A 840
GLY A 841
VAL A 848
ALA A 866
LYS A 868
GLU A 885
VAL A 916
GLY A 922
LEV  A1201 ( 3.8A)
LEV  A1201 (-3.1A)
LEV  A1201 ( 4.9A)
LEV  A1201 (-3.5A)
None
LEV  A1201 (-3.7A)
LEV  A1201 ( 4.6A)
LEV  A1201 (-3.6A)
0.57A16.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZV2_B_LEVB801_1
(FIBROBLAST GROWTH
FACTOR RECEPTOR 1)
4af3 AURORA KINASE B
(Homo
sapiens)
7 / 12LEU A  83
GLY A  84
VAL A  91
ALA A 104
ALA A 157
GLY A 160
ALA A 217
VX6  A 500 (-3.8A)
VX6  A 500 ( 4.1A)
VX6  A 500 ( 4.8A)
VX6  A 500 (-3.4A)
VX6  A 500 (-3.7A)
VX6  A 500 (-3.3A)
VX6  A 500 ( 4.2A)
0.79A13.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZV2_B_LEVB801_1
(FIBROBLAST GROWTH
FACTOR RECEPTOR 1)
4af3 AURORA KINASE B
(Homo
sapiens)
7 / 12LEU A  83
VAL A  91
ALA A 104
LYS A 106
ALA A 157
GLY A 160
ALA A 217
VX6  A 500 (-3.8A)
VX6  A 500 ( 4.8A)
VX6  A 500 (-3.4A)
VX6  A 500 (-3.3A)
VX6  A 500 (-3.7A)
VX6  A 500 (-3.3A)
VX6  A 500 ( 4.2A)
0.80A13.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZV2_B_LEVB801_1
(FIBROBLAST GROWTH
FACTOR RECEPTOR 1)
4agd VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 2
(Homo
sapiens)
7 / 12LEU A 840
PHE A1047
VAL A 848
ALA A 866
GLU A 885
VAL A 916
GLY A 922
B49  A2000 (-3.7A)
B49  A2000 (-4.0A)
None
B49  A2000 (-3.5A)
None
B49  A2000 (-4.8A)
B49  A2000 ( 3.7A)
0.83A15.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZV2_B_LEVB801_1
(FIBROBLAST GROWTH
FACTOR RECEPTOR 1)
4at3 BDNF/NT-3 GROWTH
FACTORS RECEPTOR
(Homo
sapiens)
7 / 12LEU A 560
GLY A 561
PHE A 565
VAL A 568
ALA A 586
LYS A 588
GLY A 639
LTI  A1839 ( 4.2A)
LTI  A1839 ( 4.3A)
LTI  A1839 (-3.5A)
None
LTI  A1839 (-3.3A)
None
LTI  A1839 (-3.4A)
0.69A12.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZV2_B_LEVB801_1
(FIBROBLAST GROWTH
FACTOR RECEPTOR 1)
4ckr EPITHELIAL DISCOIDIN
DOMAIN-CONTAINING
RECEPTOR 1
(Homo
sapiens)
9 / 12LEU A 616
PHE A 785
VAL A 624
ALA A 653
LYS A 655
GLU A 672
MET A 676
GLY A 707
ALA A 783
None
DI1  A1000 (-4.5A)
DI1  A1000 (-4.8A)
DI1  A1000 (-3.6A)
DI1  A1000 (-3.9A)
DI1  A1000 (-3.8A)
DI1  A1000 (-3.6A)
None
DI1  A1000 (-3.7A)
0.90A16.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZV2_B_LEVB801_1
(FIBROBLAST GROWTH
FACTOR RECEPTOR 1)
4crs SERINE/THREONINE-PRO
TEIN KINASE N2
(Homo
sapiens)
8 / 12LEU A 663
VAL A 671
ALA A 684
LYS A 686
GLU A 705
ALA A 740
GLY A 743
ALA A 799
AGS  A1985 (-4.2A)
AGS  A1985 (-4.6A)
AGS  A1985 (-3.5A)
AGS  A1985 (-3.0A)
None
AGS  A1985 (-3.9A)
None
AGS  A1985 ( 4.5A)
0.64A11.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZV2_B_LEVB801_1
(FIBROBLAST GROWTH
FACTOR RECEPTOR 1)
4eut SERINE/THREONINE-PRO
TEIN KINASE TBK1
(Homo
sapiens)
6 / 12LEU A  15
VAL A  23
ALA A  36
LYS A  38
GLU A  55
GLY A  92
BX7  A 401 (-3.7A)
BX7  A 401 (-4.4A)
BX7  A 401 (-3.4A)
BX7  A 401 ( 4.0A)
None
BX7  A 401 (-3.5A)
0.34A17.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZV2_B_LEVB801_1
(FIBROBLAST GROWTH
FACTOR RECEPTOR 1)
4euu SERINE/THREONINE-PRO
TEIN KINASE TBK1
(Homo
sapiens)
6 / 12LEU A  15
VAL A  23
ALA A  36
LYS A  38
GLU A  55
GLY A  92
BX7  A 401 (-3.9A)
BX7  A 401 ( 4.6A)
BX7  A 401 (-3.4A)
BX7  A 401 (-3.5A)
None
BX7  A 401 (-3.3A)
0.29A18.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZV2_B_LEVB801_1
(FIBROBLAST GROWTH
FACTOR RECEPTOR 1)
4f4p TYROSINE-PROTEIN
KINASE SYK
(Homo
sapiens)
7 / 12LEU A 377
VAL A 385
ALA A 400
LYS A 402
GLU A 420
MET A 424
ALA A 451
0SB  A 701 ( 3.9A)
0SB  A 701 (-4.0A)
0SB  A 701 (-3.3A)
0SB  A 701 ( 4.8A)
None
None
0SB  A 701 (-4.0A)
0.79A15.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZV2_B_LEVB801_1
(FIBROBLAST GROWTH
FACTOR RECEPTOR 1)
4gv1 RAC-ALPHA
SERINE/THREONINE-PRO
TEIN KINASE
(Homo
sapiens)
7 / 12LEU A 156
VAL A 164
ALA A 177
LYS A 179
GLU A 198
ALA A 230
GLY A 233
0XZ  A 501 ( 4.1A)
0XZ  A 501 (-4.5A)
0XZ  A 501 (-3.3A)
GOL  A 503 ( 2.8A)
GOL  A 503 (-3.6A)
0XZ  A 501 (-3.7A)
None
0.65A13.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZV2_B_LEVB801_1
(FIBROBLAST GROWTH
FACTOR RECEPTOR 1)
4hvi TYROSINE-PROTEIN
KINASE JAK3
(Homo
sapiens)
7 / 12LEU A 828
VAL A 836
ALA A 853
LYS A 855
GLU A 871
GLY A 908
ALA A 966
19S  A1201 (-3.9A)
19S  A1201 (-4.4A)
19S  A1201 (-3.3A)
19S  A1201 (-3.5A)
None
19S  A1201 ( 3.8A)
19S  A1201 ( 4.1A)
0.50A16.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZV2_B_LEVB801_1
(FIBROBLAST GROWTH
FACTOR RECEPTOR 1)
4hzs ACTIVATED CDC42
KINASE 1
(Homo
sapiens)
6 / 12LEU A 132
VAL A 140
ALA A 156
LYS A 158
ALA A 208
GLY A 211
None
0.63A15.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZV2_B_LEVB801_1
(FIBROBLAST GROWTH
FACTOR RECEPTOR 1)
4id7 ACTIVATED CDC42
KINASE 1
(Homo
sapiens)
6 / 12LEU A 132
VAL A 140
ALA A 156
LYS A 158
ALA A 208
GLY A 211
1G0  A 401 ( 4.5A)
1G0  A 401 (-4.4A)
1G0  A 401 (-3.6A)
1G0  A 401 (-3.7A)
1G0  A 401 (-3.8A)
1G0  A 401 ( 4.5A)
0.71A19.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZV2_B_LEVB801_1
(FIBROBLAST GROWTH
FACTOR RECEPTOR 1)
4jxf SERINE/THREONINE-PRO
TEIN KINASE PLK4
(Homo
sapiens)
7 / 12LEU A  18
GLY A  19
VAL A  26
ALA A  39
LYS A  41
GLY A  95
ALA A 153
631  A 301 (-3.4A)
631  A 301 (-3.6A)
631  A 301 (-4.6A)
631  A 301 (-3.3A)
631  A 301 (-2.7A)
631  A 301 ( 3.7A)
631  A 301 (-3.4A)
0.80A14.86
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5ZV2_B_LEVB801_1
(FIBROBLAST GROWTH
FACTOR RECEPTOR 1)
4k33 FIBROBLAST GROWTH
FACTOR RECEPTOR 3
(Homo
sapiens)
6 / 12LEU A 478
GLY A 479
ALA A 506
ALA A 558
GLY A 561
ALA A 634
ACP  A 801 (-3.8A)
ACP  A 801 (-3.4A)
ACP  A 801 (-3.3A)
ACP  A 801 (-3.7A)
ACP  A 801 ( 4.6A)
None
0.64A66.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5ZV2_B_LEVB801_1
(FIBROBLAST GROWTH
FACTOR RECEPTOR 1)
4k33 FIBROBLAST GROWTH
FACTOR RECEPTOR 3
(Homo
sapiens)
10 / 12LEU A 478
VAL A 486
ALA A 506
LYS A 508
GLU A 525
MET A 529
VAL A 555
ALA A 558
GLY A 561
ALA A 634
ACP  A 801 (-3.8A)
ACP  A 801 (-4.2A)
ACP  A 801 (-3.3A)
ACP  A 801 (-2.7A)
ACP  A 801 ( 4.8A)
None
ACP  A 801 (-4.7A)
ACP  A 801 (-3.7A)
ACP  A 801 ( 4.6A)
None
0.73A66.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZV2_B_LEVB801_1
(FIBROBLAST GROWTH
FACTOR RECEPTOR 1)
4l52 MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE KINASE 7,
TGF-BETA-ACTIVATED
KINASE 1 AND
MAP3K7-BINDING
PROTEIN 1 CHIMERA
(Homo
sapiens)
6 / 12VAL A  50
ALA A  61
LYS A  63
GLU A  77
ALA A 107
GLY A 110
1UL  A 501 ( 4.9A)
1UL  A 501 (-3.1A)
None
None
1UL  A 501 (-3.6A)
1UL  A 501 ( 3.7A)
0.74A13.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZV2_B_LEVB801_1
(FIBROBLAST GROWTH
FACTOR RECEPTOR 1)
4o27 SERINE/THREONINE-PRO
TEIN KINASE 24
(Homo
sapiens)
6 / 12VAL B  38
ALA B  51
LYS B  53
GLU B  70
GLY B 105
ALA B 161
ADP  B 500 (-4.5A)
ADP  B 500 (-3.3A)
ADP  B 500 (-3.1A)
None
None
None
0.50A13.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZV2_B_LEVB801_1
(FIBROBLAST GROWTH
FACTOR RECEPTOR 1)
4o38 CYCLIN-G-ASSOCIATED
KINASE
(Homo
sapiens)
6 / 12LEU A  46
VAL A  54
ALA A  67
LYS A  69
GLU A  85
GLY A 128
SIN  A 401 ( 3.9A)
None
SIN  A 401 ( 3.7A)
None
None
SIN  A 401 (-3.5A)
0.55A11.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZV2_B_LEVB801_1
(FIBROBLAST GROWTH
FACTOR RECEPTOR 1)
4q9z HUMAN PROTEIN KINASE
C THETA
(Homo
sapiens)
7 / 12LEU A 386
VAL A 394
ALA A 407
LYS A 409
GLU A 428
GLY A 464
ALA A 521
PZW  A 801 (-3.9A)
PZW  A 801 (-4.6A)
PZW  A 801 (-3.5A)
None
None
None
PZW  A 801 ( 4.6A)
0.71A11.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZV2_B_LEVB801_1
(FIBROBLAST GROWTH
FACTOR RECEPTOR 1)
4ra4 PROTEIN KINASE C
(Homo
sapiens)
7 / 12LEU A 345
VAL A 353
ALA A 366
LYS A 368
GLU A 387
GLY A 423
ALA A 480
3KZ  A 701 ( 4.1A)
3KZ  A 701 (-3.9A)
3KZ  A 701 (-3.4A)
3KZ  A 701 ( 4.7A)
None
None
3KZ  A 701 ( 4.8A)
0.92A15.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZV2_B_LEVB801_1
(FIBROBLAST GROWTH
FACTOR RECEPTOR 1)
4rt7 RECEPTOR-TYPE
TYROSINE-PROTEIN
KINASE FLT3
(Homo
sapiens)
7 / 12LEU A 616
PHE A 830
VAL A 624
ALA A 642
LYS A 644
GLU A 661
GLY A 697
P30  A1001 (-3.8A)
P30  A1001 (-3.9A)
None
P30  A1001 (-3.4A)
P30  A1001 (-3.4A)
P30  A1001 (-3.6A)
P30  A1001 (-3.4A)
0.74A12.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZV2_B_LEVB801_1
(FIBROBLAST GROWTH
FACTOR RECEPTOR 1)
4tnb G PROTEIN-COUPLED
RECEPTOR KINASE 5
(Homo
sapiens)
6 / 12LEU A 192
VAL A 200
ALA A 213
LYS A 215
GLU A 234
GLY A 268
SGV  A 601 (-4.1A)
SGV  A 601 ( 4.6A)
SGV  A 601 (-3.3A)
SGV  A 601 ( 4.2A)
None
None
0.65A9.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZV2_B_LEVB801_1
(FIBROBLAST GROWTH
FACTOR RECEPTOR 1)
4wb7 DNAJ HOMOLOG
SUBFAMILY B MEMBER
1,CAMP-DEPENDENT
PROTEIN KINASE
CATALYTIC SUBUNIT
ALPHA
(Homo
sapiens)
6 / 12LEU A 104
VAL A 112
ALA A 125
LYS A 127
GLU A 146
GLY A 181
ATP  A 501 ( 4.3A)
ATP  A 501 (-4.0A)
ATP  A 501 (-3.4A)
ATP  A 501 (-2.6A)
None
None
0.41A14.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZV2_B_LEVB801_1
(FIBROBLAST GROWTH
FACTOR RECEPTOR 1)
4wsq AP2-ASSOCIATED
PROTEIN KINASE 1
(Homo
sapiens)
7 / 12LEU A  52
VAL A  60
ALA A  72
LYS A  74
GLU A  90
MET A  94
GLY A 132
KSA  A 405 ( 4.0A)
KSA  A 405 ( 4.9A)
KSA  A 405 (-3.2A)
None
None
None
KSA  A 405 (-3.5A)
0.92A14.38
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5ZV2_B_LEVB801_1
(FIBROBLAST GROWTH
FACTOR RECEPTOR 1)
4xcu FIBROBLAST GROWTH
FACTOR RECEPTOR 4
(Homo
sapiens)
10 / 12LEU A 473
VAL A 481
ALA A 501
LYS A 503
GLU A 520
MET A 524
VAL A 550
ALA A 553
GLY A 556
ALA A 629
40M  A1002 ( 4.6A)
40M  A1002 ( 4.5A)
40M  A1002 ( 4.1A)
40M  A1002 (-4.0A)
40M  A1002 (-3.7A)
40M  A1002 (-3.8A)
40M  A1002 (-4.7A)
40M  A1002 (-3.7A)
40M  A1002 ( 3.7A)
40M  A1002 (-3.0A)
0.55A65.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZV2_B_LEVB801_1
(FIBROBLAST GROWTH
FACTOR RECEPTOR 1)
4xuf RECEPTOR-TYPE
TYROSINE-PROTEIN
KINASE FLT3
(Homo
sapiens)
7 / 12GLY A 617
PHE A 830
ALA A 642
LYS A 644
GLU A 661
MET A 665
GLY A 697
None
P30  A1001 ( 4.1A)
P30  A1001 (-3.5A)
P30  A1001 ( 4.0A)
P30  A1001 (-3.1A)
P30  A1001 (-4.4A)
P30  A1001 (-3.5A)
1.18A14.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZV2_B_LEVB801_1
(FIBROBLAST GROWTH
FACTOR RECEPTOR 1)
4xuf RECEPTOR-TYPE
TYROSINE-PROTEIN
KINASE FLT3
(Homo
sapiens)
7 / 12LEU A 616
GLY A 617
PHE A 830
ALA A 642
LYS A 644
GLU A 661
GLY A 697
P30  A1001 (-4.0A)
None
P30  A1001 ( 4.1A)
P30  A1001 (-3.5A)
P30  A1001 ( 4.0A)
P30  A1001 (-3.1A)
P30  A1001 (-3.5A)
1.17A14.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZV2_B_LEVB801_1
(FIBROBLAST GROWTH
FACTOR RECEPTOR 1)
4xuf RECEPTOR-TYPE
TYROSINE-PROTEIN
KINASE FLT3
(Homo
sapiens)
7 / 12LEU A 616
PHE A 830
VAL A 624
ALA A 642
LYS A 644
GLU A 661
GLY A 697
P30  A1001 (-4.0A)
P30  A1001 ( 4.1A)
P30  A1001 ( 4.8A)
P30  A1001 (-3.5A)
P30  A1001 ( 4.0A)
P30  A1001 (-3.1A)
P30  A1001 (-3.5A)
0.81A14.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZV2_B_LEVB801_1
(FIBROBLAST GROWTH
FACTOR RECEPTOR 1)
4xuf RECEPTOR-TYPE
TYROSINE-PROTEIN
KINASE FLT3
(Homo
sapiens)
7 / 12PHE A 830
VAL A 624
ALA A 642
LYS A 644
GLU A 661
MET A 665
GLY A 697
P30  A1001 ( 4.1A)
P30  A1001 ( 4.8A)
P30  A1001 (-3.5A)
P30  A1001 ( 4.0A)
P30  A1001 (-3.1A)
P30  A1001 (-4.4A)
P30  A1001 (-3.5A)
0.90A14.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZV2_B_LEVB801_1
(FIBROBLAST GROWTH
FACTOR RECEPTOR 1)
4yff SERINE/THREONINE-PRO
TEIN KINASE TNNI3K
(Homo
sapiens)
6 / 12VAL A 477
ALA A 488
LYS A 490
GLU A 509
GLY A 545
ALA A 605
None
4CV  A 801 (-3.5A)
4CV  A 801 (-3.9A)
None
4CV  A 801 ( 4.0A)
4CV  A 801 ( 3.9A)
0.64A12.66
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5ZV2_B_LEVB801_1
(FIBROBLAST GROWTH
FACTOR RECEPTOR 1)
5a46 FIBROBLAST GROWTH
FACTOR RECEPTOR 1
(FMS-RELATED
TYROSINE KINASE 2,
PFEIFFER SYNDROME),
ISOFORM CRA_B
(Homo
sapiens)
7 / 12LEU A 484
GLY A 485
ALA A 512
MET A 535
VAL A 561
ALA A 564
ALA A 640
38O  A1769 (-3.2A)
38O  A1769 ( 4.7A)
38O  A1769 (-3.6A)
EDO  A1766 (-3.5A)
38O  A1769 (-4.3A)
38O  A1769 (-3.9A)
EDO  A1766 ( 4.4A)
1.07A78.22
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5ZV2_B_LEVB801_1
(FIBROBLAST GROWTH
FACTOR RECEPTOR 1)
5a46 FIBROBLAST GROWTH
FACTOR RECEPTOR 1
(FMS-RELATED
TYROSINE KINASE 2,
PFEIFFER SYNDROME),
ISOFORM CRA_B
(Homo
sapiens)
10 / 12LEU A 484
VAL A 492
ALA A 512
LYS A 514
GLU A 531
MET A 535
VAL A 561
ALA A 564
GLY A 567
ALA A 640
38O  A1769 (-3.2A)
38O  A1769 (-4.5A)
38O  A1769 (-3.6A)
38O  A1769 ( 3.1A)
EDO  A1766 (-4.1A)
EDO  A1766 (-3.5A)
38O  A1769 (-4.3A)
38O  A1769 (-3.9A)
38O  A1769 (-3.4A)
EDO  A1766 ( 4.4A)
0.52A78.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZV2_B_LEVB801_1
(FIBROBLAST GROWTH
FACTOR RECEPTOR 1)
5es1 MAP/MICROTUBULE
AFFINITY-REGULATING
KINASE 4
(Homo
sapiens)
7 / 12VAL A  70
ALA A  83
LYS A  85
GLU A 103
ALA A 135
GLY A 138
ALA A 195
5RC  A4000 (-4.6A)
5RC  A4000 (-3.6A)
5RC  A4000 (-2.8A)
None
5RC  A4000 (-3.7A)
5RC  A4000 (-3.3A)
5RC  A4000 ( 3.9A)
0.76A11.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZV2_B_LEVB801_1
(FIBROBLAST GROWTH
FACTOR RECEPTOR 1)
5f1z NON-RECEPTOR
TYROSINE-PROTEIN
KINASE TYK2
(Homo
sapiens)
6 / 12LEU A 903
VAL A 911
ALA A 928
LYS A 930
GLU A 947
GLY A 984
5U3  A1200 (-3.8A)
5U3  A1200 ( 4.4A)
5U3  A1200 (-3.5A)
None
None
5U3  A1200 (-3.2A)
0.67A15.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZV2_B_LEVB801_1
(FIBROBLAST GROWTH
FACTOR RECEPTOR 1)
5fm2 PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE RECEPTOR RET
(Homo
sapiens)
6 / 12LEU A 730
VAL A 738
ALA A 756
LYS A 758
GLU A 775
VAL A 804
PP1  A2012 (-4.6A)
PP1  A2012 (-4.4A)
PP1  A2012 (-3.2A)
PP1  A2012 (-4.1A)
PP1  A2012 (-3.5A)
PP1  A2012 (-4.5A)
0.44A13.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZV2_B_LEVB801_1
(FIBROBLAST GROWTH
FACTOR RECEPTOR 1)
5fm2 PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE RECEPTOR RET
(Homo
sapiens)
6 / 12LEU A 730
VAL A 738
ALA A 756
LYS A 758
VAL A 804
ALA A 807
PP1  A2012 (-4.6A)
PP1  A2012 (-4.4A)
PP1  A2012 (-3.2A)
PP1  A2012 (-4.1A)
PP1  A2012 (-4.5A)
PP1  A2012 ( 3.5A)
0.56A13.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZV2_B_LEVB801_1
(FIBROBLAST GROWTH
FACTOR RECEPTOR 1)
5fm2 PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE RECEPTOR RET
(Homo
sapiens)
6 / 12LEU A 730
VAL A 738
ALA A 756
VAL A 804
ALA A 807
GLY A 810
PP1  A2012 (-4.6A)
PP1  A2012 (-4.4A)
PP1  A2012 (-3.2A)
PP1  A2012 (-4.5A)
PP1  A2012 ( 3.5A)
PTR  A 809 (-2.4A)
0.63A13.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZV2_B_LEVB801_1
(FIBROBLAST GROWTH
FACTOR RECEPTOR 1)
5grn PLATELET-DERIVED
GROWTH FACTOR
RECEPTOR ALPHA
(Homo
sapiens)
7 / 12LEU A 599
VAL A 607
ALA A 625
LYS A 627
GLU A 644
MET A 648
GLY A 680
748  A1001 (-3.8A)
748  A1001 ( 4.7A)
748  A1001 (-3.7A)
748  A1001 (-4.0A)
748  A1001 (-3.3A)
748  A1001 (-3.4A)
748  A1001 ( 4.0A)
0.59A17.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZV2_B_LEVB801_1
(FIBROBLAST GROWTH
FACTOR RECEPTOR 1)
5grn PLATELET-DERIVED
GROWTH FACTOR
RECEPTOR ALPHA
(Homo
sapiens)
7 / 12PHE A 837
VAL A 607
ALA A 625
LYS A 627
GLU A 644
MET A 648
GLY A 680
748  A1001 (-3.7A)
748  A1001 ( 4.7A)
748  A1001 (-3.7A)
748  A1001 (-4.0A)
748  A1001 (-3.3A)
748  A1001 (-3.4A)
748  A1001 ( 4.0A)
0.88A17.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZV2_B_LEVB801_2
(FIBROBLAST GROWTH
FACTOR RECEPTOR 1)
1zlt SERINE/THREONINE-PRO
TEIN KINASE CHK1
(Homo
sapiens)
3 / 3TYR A  86
LEU A 137
ASP A 148
HYM  A 400 (-4.7A)
HYM  A 400 (-4.5A)
HYM  A 400 (-3.9A)
0.70A22.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZV2_B_LEVB801_2
(FIBROBLAST GROWTH
FACTOR RECEPTOR 1)
2dq7 PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE FYN
(Homo
sapiens)
3 / 3TYR X  84
LEU X 137
ASP X 148
STU  X 902 (-4.6A)
STU  X 902 (-4.4A)
STU  X 902 (-3.6A)
0.64A16.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZV2_B_LEVB801_2
(FIBROBLAST GROWTH
FACTOR RECEPTOR 1)
2h8h PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC
(Homo
sapiens)
3 / 3TYR A 340
LEU A 393
ASP A 404
H8H  A 534 (-4.3A)
H8H  A 534 (-4.5A)
H8H  A 534 (-4.2A)
0.62A9.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZV2_B_LEVB801_2
(FIBROBLAST GROWTH
FACTOR RECEPTOR 1)
2qyk CYCLIC AMP-SPECIFIC
PHOSPHODIESTERASE
HSPDE4A10
(Homo
sapiens)
3 / 3TYR A 371
LEU A 375
ASP A 323
NPV  A   3 (-4.4A)
None
None
0.87A12.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZV2_B_LEVB801_2
(FIBROBLAST GROWTH
FACTOR RECEPTOR 1)
2vd5 DMPK PROTEIN
(Homo
sapiens)
3 / 3TYR A 150
LEU A 202
ASP A 213
BI8  A1417 (-4.8A)
BI8  A1417 (-4.8A)
BI8  A1417 (-3.8A)
0.84A11.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZV2_B_LEVB801_2
(FIBROBLAST GROWTH
FACTOR RECEPTOR 1)
2xik SERINE/THREONINE
PROTEIN KINASE 25
(Homo
sapiens)
3 / 3TYR A  97
LEU A 147
ASP A 158
J60  A1294 (-4.5A)
J60  A1294 (-4.8A)
J60  A1294 ( 4.6A)
0.70A14.38
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5ZV2_B_LEVB801_2
(FIBROBLAST GROWTH
FACTOR RECEPTOR 1)
3c4f BASIC FIBROBLAST
GROWTH FACTOR
RECEPTOR 1
(Homo
sapiens)
3 / 3TYR A 563
LEU A 630
ASP A 641
None
C4F  A   1 (-4.6A)
C4F  A   1 (-4.5A)
0.31A100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZV2_B_LEVB801_2
(FIBROBLAST GROWTH
FACTOR RECEPTOR 1)
3d7u TYROSINE-PROTEIN
KINASE CSK
(Homo
sapiens)
3 / 3TYR A 268
LEU A 321
ASP A 332
None
0.59A15.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZV2_B_LEVB801_2
(FIBROBLAST GROWTH
FACTOR RECEPTOR 1)
3g2f BONE MORPHOGENETIC
PROTEIN RECEPTOR
TYPE-2
(Homo
sapiens)
3 / 3TYR A 281
LEU A 340
ASP A 351
None
ADP  A 900 (-4.6A)
ADP  A 900 ( 2.7A)
0.77A13.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZV2_B_LEVB801_2
(FIBROBLAST GROWTH
FACTOR RECEPTOR 1)
3gbj KIF13B PROTEIN
(Homo
sapiens)
3 / 3TYR A 182
LEU A 171
ASP A 163
None
0.75A11.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZV2_B_LEVB801_2
(FIBROBLAST GROWTH
FACTOR RECEPTOR 1)
3jar MICROTUBULE-ASSOCIAT
ED PROTEIN RP/EB
FAMILY MEMBER 3
(Homo
sapiens)
3 / 3TYR N 124
LEU N  51
ASP N 116
None
0.85A20.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZV2_B_LEVB801_2
(FIBROBLAST GROWTH
FACTOR RECEPTOR 1)
3kul EPHRIN TYPE-A
RECEPTOR 8
(Homo
sapiens)
3 / 3TYR A 715
LEU A 767
ASP A 778
GOL  A 403 (-4.1A)
None
None
0.59A13.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZV2_B_LEVB801_2
(FIBROBLAST GROWTH
FACTOR RECEPTOR 1)
3lm5 SERINE/THREONINE-PRO
TEIN KINASE 17B
(Homo
sapiens)
3 / 3TYR A 112
LEU A 165
ASP A 179
QUE  A   1 (-4.9A)
None
QUE  A   1 (-2.9A)
0.71A12.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZV2_B_LEVB801_2
(FIBROBLAST GROWTH
FACTOR RECEPTOR 1)
3mdy BONE MORPHOGENETIC
PROTEIN RECEPTOR
TYPE-1B
(Homo
sapiens)
3 / 3TYR A 281
LEU A 339
ASP A 350
LDN  A   1 ( 4.8A)
LDN  A   1 (-4.5A)
LDN  A   1 (-3.9A)
0.77A12.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZV2_B_LEVB801_2
(FIBROBLAST GROWTH
FACTOR RECEPTOR 1)
3mos TRANSKETOLASE
(Homo
sapiens)
3 / 3TYR A  83
LEU A  73
ASP A 183
None
EDO  A 627 (-4.4A)
TPP  A 700 ( 4.5A)
0.84A7.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZV2_B_LEVB801_2
(FIBROBLAST GROWTH
FACTOR RECEPTOR 1)
3ner CYTOCHROME B5 TYPE B
(Homo
sapiens)
3 / 3TYR A   6
LEU A  84
ASP A  53
None
0.79A28.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZV2_B_LEVB801_2
(FIBROBLAST GROWTH
FACTOR RECEPTOR 1)
3ntc FAB HEAVY CHAIN
FAB LIGHT CHAIN
(Homo
sapiens;
Mus
musculus)
3 / 3TYR H 102
LEU L  46
ASP L  91
None
None
EDO  H 220 ( 4.5A)
0.61A18.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZV2_B_LEVB801_2
(FIBROBLAST GROWTH
FACTOR RECEPTOR 1)
3s95 LIM DOMAIN KINASE 1
(Homo
sapiens)
3 / 3TYR A 415
LEU A 467
ASP A 478
STU  A   1 (-4.7A)
STU  A   1 (-4.6A)
STU  A   1 ( 4.2A)
0.64A14.33
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5ZV2_B_LEVB801_2
(FIBROBLAST GROWTH
FACTOR RECEPTOR 1)
3tt0 BASIC FIBROBLAST
GROWTH FACTOR
RECEPTOR 1
(Homo
sapiens)
3 / 3TYR A 563
LEU A 630
ASP A 641
07J  A   1 (-4.7A)
07J  A   1 ( 4.4A)
07J  A   1 (-4.7A)
0.52A59.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZV2_B_LEVB801_2
(FIBROBLAST GROWTH
FACTOR RECEPTOR 1)
4bgq CYCLIN-DEPENDENT
KINASE-LIKE 5
(Homo
sapiens)
3 / 3TYR A  91
LEU A 142
ASP A 153
38R  A1000 (-4.8A)
38R  A1000 ( 4.5A)
38R  A1000 ( 4.2A)
0.80A11.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZV2_B_LEVB801_2
(FIBROBLAST GROWTH
FACTOR RECEPTOR 1)
4crs SERINE/THREONINE-PRO
TEIN KINASE N2
(Homo
sapiens)
3 / 3TYR A 739
LEU A 789
ASP A 800
None
AGS  A1985 (-4.8A)
AGS  A1985 ( 3.3A)
0.78A11.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZV2_B_LEVB801_2
(FIBROBLAST GROWTH
FACTOR RECEPTOR 1)
4hvi TYROSINE-PROTEIN
KINASE JAK3
(Homo
sapiens)
3 / 3TYR A 904
LEU A 956
ASP A 967
19S  A1201 (-4.7A)
19S  A1201 (-4.5A)
19S  A1201 ( 4.1A)
0.86A16.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZV2_B_LEVB801_2
(FIBROBLAST GROWTH
FACTOR RECEPTOR 1)
4k11 PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC
(Homo
sapiens)
3 / 3TYR A 340
LEU A 393
ASP A 404
0J9  A 601 ( 4.7A)
0J9  A 601 (-4.5A)
0J9  A 601 (-3.1A)
0.69A10.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZV2_B_LEVB801_2
(FIBROBLAST GROWTH
FACTOR RECEPTOR 1)
4p2k EPHRIN TYPE-A
RECEPTOR 2
(Homo
sapiens)
3 / 3TYR A 694
LEU A 746
ASP A 757
None
0.58A13.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZV2_B_LEVB801_2
(FIBROBLAST GROWTH
FACTOR RECEPTOR 1)
4q9z HUMAN PROTEIN KINASE
C THETA
(Homo
sapiens)
3 / 3TYR A 460
LEU A 511
ASP A 522
None
PZW  A 801 (-4.8A)
PZW  A 801 (-3.2A)
0.60A11.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZV2_B_LEVB801_2
(FIBROBLAST GROWTH
FACTOR RECEPTOR 1)
4um8 INTEGRIN BETA-6
(Homo
sapiens)
3 / 3TYR B 120
LEU B 155
ASP B 202
None
0.79A7.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZV2_B_LEVB801_2
(FIBROBLAST GROWTH
FACTOR RECEPTOR 1)
4wfs TRNA-DIHYDROURIDINE(
20) SYNTHASE
[NAD(P)+]-LIKE
(Homo
sapiens)
3 / 3TYR A 270
LEU A  25
ASP A  64
None
0.81A13.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZV2_B_LEVB801_2
(FIBROBLAST GROWTH
FACTOR RECEPTOR 1)
4wjl INACTIVE DIPEPTIDYL
PEPTIDASE 10
(Homo
sapiens)
3 / 3TYR A 767
LEU A 774
ASP A 585
None
0.82A8.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZV2_B_LEVB801_2
(FIBROBLAST GROWTH
FACTOR RECEPTOR 1)
4xgm MITOCHONDRIAL
RIBONUCLEASE P
PROTEIN 3
(Homo
sapiens)
3 / 3TYR A 307
LEU A 279
ASP A 561
None
0.61A13.33
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5ZV2_B_LEVB801_2
(FIBROBLAST GROWTH
FACTOR RECEPTOR 1)
5a46 FIBROBLAST GROWTH
FACTOR RECEPTOR 1
(FMS-RELATED
TYROSINE KINASE 2,
PFEIFFER SYNDROME),
ISOFORM CRA_B
(Homo
sapiens)
3 / 3TYR A 563
LEU A 630
ASP A 641
38O  A1769 (-4.2A)
38O  A1769 (-4.6A)
38O  A1769 (-4.0A)
0.46A78.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZV2_B_LEVB801_2
(FIBROBLAST GROWTH
FACTOR RECEPTOR 1)
5es1 MAP/MICROTUBULE
AFFINITY-REGULATING
KINASE 4
(Homo
sapiens)
3 / 3TYR A 134
LEU A 185
ASP A 196
5RC  A4000 (-4.5A)
None
5RC  A4000 (-3.6A)
0.89A11.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZV2_B_LEVB801_2
(FIBROBLAST GROWTH
FACTOR RECEPTOR 1)
5idn CYCLIN-DEPENDENT
KINASE 8
(Homo
sapiens)
3 / 3TYR A  99
LEU A 158
ASP A 173
6A7  A 401 (-4.9A)
6A7  A 401 (-4.8A)
FMT  A 403 ( 3.3A)
0.80A13.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZV2_B_LEVB801_2
(FIBROBLAST GROWTH
FACTOR RECEPTOR 1)
5jpn COMPLEMENT C4-A
(Homo
sapiens)
3 / 3TYR B 977
LEU B1362
ASP B 965
PBM  B1515 ( 4.9A)
None
None
0.85A7.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZV2_B_LEVB801_2
(FIBROBLAST GROWTH
FACTOR RECEPTOR 1)
5u7q RHO-ASSOCIATED
PROTEIN KINASE 2
(Homo
sapiens)
3 / 3TYR A 171
LEU A 221
ASP A 232
None
0.67A12.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZV2_B_LEVB801_2
(FIBROBLAST GROWTH
FACTOR RECEPTOR 1)
5vi6 HISTONE DEACETYLASE
8
(Homo
sapiens)
3 / 3TYR A 306
LEU A 179
ASP A 233
EDO  A 407 ( 3.3A)
None
None
0.71A10.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZV2_B_LEVB801_2
(FIBROBLAST GROWTH
FACTOR RECEPTOR 1)
5wdh KINESIN-LIKE PROTEIN
KIFC1
(Homo
sapiens)
3 / 3TYR A 402
LEU A 394
ASP A 375
None
0.82A13.92