POTENTIAL TARGETS FROM HUMAN (RESULTS FROM SUB-STRUCTURAL SIMILARITY SEARCHES)1) User may click on the DrReposER ID (the second column) to get information on the binding sites and drug molecule.
2) Click View (the second last column) to view matched residues and superposition in the NGL viewer (upper right part).
3) User may also click on the Dock (the last column) to get script for molecular docking in UCSF Chimera through AutoDock Vina.

	DrReposER ID / Desc.	Hit PDBID	Hit Macromolecule	Res. Matches	Interface	HETATM	RMSD	Seq. Identity (%)	View	Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5XPR_A_K86A1201_1 (ENDOTHELIN B RECEPTOR,ENDOLYSIN,E NDOTHELIN B RECEPTOR)	2p3g	MAP KINASE-ACTIVATED PROTEIN KINASE 2 (Homo sapiens)	5 / 12	VAL X 187 LEU X 177 HIS X 178 ILE X 117 ALA X 173	None	1.47A	21.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5XPR_A_K86A1201_1 (ENDOTHELIN B RECEPTOR,ENDOLYSIN,E NDOTHELIN B RECEPTOR)	3she	MAP KINASE-ACTIVATED PROTEIN KINASE 3 (Homo sapiens)	5 / 12	VAL A 167 LEU A 157 HIS A 158 ILE A  97 ALA A 153	None	1.47A	21.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5XPR_A_K86A1201_1 (ENDOTHELIN B RECEPTOR,ENDOLYSIN,E NDOTHELIN B RECEPTOR)	4cak	INTEGRIN ALPHA-IIB INTEGRIN BETA-3 (Homo sapiens)	5 / 12	GLN A 351 LEU B 246 ARG A 317 ILE B 226 ALA B 229	None	1.34A	21.05
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	5XPR_A_K86A1201_1 (ENDOTHELIN B RECEPTOR,ENDOLYSIN,E NDOTHELIN B RECEPTOR)	5gli	ENDOTHELIN RECEPTOR SUBTYPE-B (Homo sapiens)	7 / 12	VAL A 185 LYS A 273 TRP A 336 LEU A 339 ARG A 343 ILE A 372 ALA A 375	None	0.93A	99.78
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	5XPR_A_K86A1201_1 (ENDOTHELIN B RECEPTOR,ENDOLYSIN,E NDOTHELIN B RECEPTOR)	5gli	ENDOTHELIN RECEPTOR SUBTYPE-B (Homo sapiens)	7 / 12	VAL A 185 LYS A 273 TRP A 336 LEU A 339 HIS A 340 ILE A 372 ALA A 375	None	0.79A	99.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5XPR_A_K86A1201_1 (ENDOTHELIN B RECEPTOR,ENDOLYSIN,E NDOTHELIN B RECEPTOR)	5n2s	SOLUBLE CYTOCHROME B562,ADENOSINE RECEPTOR A1 (Escherichia coli; Homo sapiens)	5 / 12	TRP A1352 LEU A1355 HIS A1356 ILE A1379 ALA A1382	None 8K8  A2001 ( 4.3A) 8K8  A2001 ( 4.1A) 8K8  A2001 ( 4.2A) None	0.54A	24.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5XPR_A_K86A1201_1 (ENDOTHELIN B RECEPTOR,ENDOLYSIN,E NDOTHELIN B RECEPTOR)	5nv6	TRANSFORMING GROWTH FACTOR-BETA-INDUCED PROTEIN IG-H3 (Homo sapiens)	5 / 12	HIS A 174 VAL A 235 LEU A 156 LEU A 167 ALA A 170	None	1.47A	22.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5XPR_A_K86A1201_1 (ENDOTHELIN B RECEPTOR,ENDOLYSIN,E NDOTHELIN B RECEPTOR)	6chd	LYSINE--TRNA LIGASE (Homo sapiens)	5 / 12	GLN A 515 VAL A 279 LEU A 472 ILE A 468 ALA A 441	None	1.33A	13.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5XPR_A_K86A1201_1 (ENDOTHELIN B RECEPTOR,ENDOLYSIN,E NDOTHELIN B RECEPTOR)	6gru	ADP-SUGAR PYROPHOSPHATASE (Homo sapiens)	5 / 12	VAL A 193 LEU A 185 LEU A 178 ILE A  77 ALA A 201	None	1.39A	11.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5XPR_A_K86A1201_2 (ENDOTHELIN B RECEPTOR,ENDOLYSIN,E NDOTHELIN B RECEPTOR)	4krf	PROTEIN ARGONAUTE-1 (Homo sapiens)	4 / 4	ASP A 667 PRO A 670 GLU A 671 TYR A 764	None	1.34A	19.19