POTENTIAL TARGETS FROM HUMAN (RESULTS FROM SUB-STRUCTURAL SIMILARITY SEARCHES)
1) User may click on the DrReposER ID (the second column) to get information on the binding sites and drug molecule.
2) Click View (the second last column) to view matched residues and superposition in the NGL viewer (upper right part).
3) User may also click on the Dock (the last column) to get script for molecular docking in UCSF Chimera through AutoDock Vina.

DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6MXT_A_K5YA1401_0
(ENDOLYSIN, BETA-2
ADRENERGIC RECEPTOR
CHIMERA)		1s9v HLA CLASS II
HISTOCOMPATIBILITY
ANTIGEN, DQ(3) ALPHA
CHAIN
(Homo
sapiens)		5 / 12PHE A  58
HIS A  24
TYR A  22
ILE A  63
ASN A  62
EDO  A 501 (-4.6A)
EDO  A 504 (-4.3A)
None
None
None
1.29A17.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6MXT_A_K5YA1401_0
(ENDOLYSIN, BETA-2
ADRENERGIC RECEPTOR
CHIMERA)		2wgh RIBONUCLEOSIDE-DIPHO
SPHATE REDUCTASE
LARGE SUBUNIT
(Homo
sapiens)		5 / 12VAL A 443
HIS A 200
ILE A 483
ASN A 484
TYR A 486
None
1.42A22.38
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
6MXT_A_K5YA1401_0
(ENDOLYSIN, BETA-2
ADRENERGIC RECEPTOR
CHIMERA)		3pds FUSION PROTEIN
BETA-2 ADRENERGIC
RECEPTOR/LYSOZYME
(Homo
sapiens;
Escherichia
virus
T4)		10 / 12TRP A 109
VAL A 114
ASP A 192
PHE A 193
PHE A 289
ASN A 293
TYR A 308
ILE A 309
ASN A 312
TYR A 316
None
ERC  A1201 (-3.8A)
ERC  A1201 (-4.2A)
ERC  A1201 (-4.4A)
ERC  A1201 (-4.5A)
ERC  A1201 (-3.5A)
None
ERC  A1201 (-4.1A)
ERC  A1201 (-3.0A)
None
0.67A57.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
6MXT_A_K5YA1401_0
(ENDOLYSIN, BETA-2
ADRENERGIC RECEPTOR
CHIMERA)		3pds FUSION PROTEIN
BETA-2 ADRENERGIC
RECEPTOR/LYSOZYME
(Homo
sapiens;
Escherichia
virus
T4)		5 / 12TRP A 109
VAL A 114
PHE A 289
ASN A 293
TYR A 308
None
ERC  A1201 (-3.8A)
ERC  A1201 (-4.5A)
ERC  A1201 (-3.5A)
None
1.39A57.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
6MXT_A_K5YA1401_0
(ENDOLYSIN, BETA-2
ADRENERGIC RECEPTOR
CHIMERA)		3pds FUSION PROTEIN
BETA-2 ADRENERGIC
RECEPTOR/LYSOZYME
(Homo
sapiens;
Escherichia
virus
T4)		10 / 12TRP A 109
VAL A 114
VAL A 117
ASP A 192
PHE A 193
PHE A 289
ASN A 293
TYR A 308
ASN A 312
TYR A 316
None
ERC  A1201 (-3.8A)
None
ERC  A1201 (-4.2A)
ERC  A1201 (-4.4A)
ERC  A1201 (-4.5A)
ERC  A1201 (-3.5A)
None
ERC  A1201 (-3.0A)
None
0.71A57.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
6MXT_A_K5YA1401_0
(ENDOLYSIN, BETA-2
ADRENERGIC RECEPTOR
CHIMERA)		4gbr BETA-2 ADRENERGIC
RECEPTOR
(Homo
sapiens)		6 / 12ASP A 192
HIS A 268
TYR A 280
ILE A 281
ASN A 284
TYR A 288
None
None
None
None
CAU  A 500 (-3.3A)
CAU  A 500 (-4.6A)
1.33A100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
6MXT_A_K5YA1401_0
(ENDOLYSIN, BETA-2
ADRENERGIC RECEPTOR
CHIMERA)		4gbr BETA-2 ADRENERGIC
RECEPTOR
(Homo
sapiens)		7 / 12TRP A 109
ASP A 192
PHE A 261
ASN A 265
TYR A 280
ILE A 281
TYR A 288
None
None
CAU  A 500 (-4.2A)
CAU  A 500 (-3.4A)
None
None
CAU  A 500 (-4.6A)
0.87A100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
6MXT_A_K5YA1401_0
(ENDOLYSIN, BETA-2
ADRENERGIC RECEPTOR
CHIMERA)		4gbr BETA-2 ADRENERGIC
RECEPTOR
(Homo
sapiens)		7 / 12TRP A 109
ASP A 192
PHE A 261
TYR A 280
ILE A 281
ASN A 284
TYR A 288
None
None
CAU  A 500 (-4.2A)
None
None
CAU  A 500 (-3.3A)
CAU  A 500 (-4.6A)
0.79A100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
6MXT_A_K5YA1401_0
(ENDOLYSIN, BETA-2
ADRENERGIC RECEPTOR
CHIMERA)		4gbr BETA-2 ADRENERGIC
RECEPTOR
(Homo
sapiens)		8 / 12TRP A 109
VAL A 114
ASP A 192
PHE A 193
PHE A 261
TYR A 280
ASN A 284
TYR A 288
None
CAU  A 500 (-3.5A)
None
CAU  A 500 (-4.5A)
CAU  A 500 (-4.2A)
None
CAU  A 500 (-3.3A)
CAU  A 500 (-4.6A)
0.74A100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
6MXT_A_K5YA1401_0
(ENDOLYSIN, BETA-2
ADRENERGIC RECEPTOR
CHIMERA)		4gbr BETA-2 ADRENERGIC
RECEPTOR
(Homo
sapiens)		9 / 12TRP A 109
VAL A 114
VAL A 117
ASP A 192
PHE A 193
PHE A 261
ASN A 265
TYR A 280
TYR A 288
None
CAU  A 500 (-3.5A)
CAU  A 500 (-4.2A)
None
CAU  A 500 (-4.5A)
CAU  A 500 (-4.2A)
CAU  A 500 (-3.4A)
None
CAU  A 500 (-4.6A)
0.78A100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6MXT_A_K5YA1401_0
(ENDOLYSIN, BETA-2
ADRENERGIC RECEPTOR
CHIMERA)		4ib4 CHIMERA PROTEIN OF
HUMAN
5-HYDROXYTRYPTAMINE
RECEPTOR 2B AND E.
COLI SOLUBLE
CYTOCHROME B562
(Escherichia
coli;
Homo
sapiens)		5 / 12TRP A 131
VAL A 136
PHE A 340
ASN A 344
TYR A 370
None
ERM  A2001 (-3.8A)
ERM  A2001 (-4.3A)
ERM  A2001 (-4.3A)
ERM  A2001 ( 4.8A)
0.59A25.39
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
6MXT_A_K5YA1401_0
(ENDOLYSIN, BETA-2
ADRENERGIC RECEPTOR
CHIMERA)		4lde LYSOZYME, BETA-2
ADRENERGIC RECEPTOR
(Homo
sapiens;
Escherichia
virus
T4)		5 / 12TRP A1109
ASP A1192
HIS A1296
TYR A1308
ILE A1309
None
None
None
None
P0G  A1401 (-4.1A)
1.06A99.78
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
6MXT_A_K5YA1401_0
(ENDOLYSIN, BETA-2
ADRENERGIC RECEPTOR
CHIMERA)		4lde LYSOZYME, BETA-2
ADRENERGIC RECEPTOR
(Homo
sapiens;
Escherichia
virus
T4)		11 / 12TRP A1109
VAL A1114
VAL A1117
ASP A1192
PHE A1193
PHE A1289
ASN A1293
TYR A1308
ILE A1309
ASN A1312
TYR A1316
None
P0G  A1401 (-3.7A)
P0G  A1401 ( 4.4A)
None
P0G  A1401 (-3.8A)
P0G  A1401 ( 4.7A)
P0G  A1401 (-3.0A)
None
P0G  A1401 (-4.1A)
P0G  A1401 (-2.9A)
None
0.48A99.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6MXT_A_K5YA1401_0
(ENDOLYSIN, BETA-2
ADRENERGIC RECEPTOR
CHIMERA)		5jcg THIOREDOXIN-DEPENDEN
T PEROXIDE
REDUCTASE,
MITOCHONDRIAL
(Homo
sapiens)		5 / 12VAL A  69
VAL A  71
ASP A 129
ILE A 134
TYR A 111
None
1.35A18.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6MXT_A_K5YA1401_0
(ENDOLYSIN, BETA-2
ADRENERGIC RECEPTOR
CHIMERA)		5tus RIBONUCLEOSIDE-DIPHO
SPHATE REDUCTASE
LARGE SUBUNIT
(Homo
sapiens)		5 / 12VAL A 443
HIS A 200
ILE A 483
ASN A 484
TYR A 486
None
1.34A20.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6MXT_A_K5YA1401_0
(ENDOLYSIN, BETA-2
ADRENERGIC RECEPTOR
CHIMERA)		5wde KINESIN-LIKE PROTEIN
KIFC3
(Homo
sapiens)		5 / 12VAL A 452
VAL A 745
ASP A 472
PHE A 471
ASN A 467
None
None
UNX  A 909 ( 3.7A)
None
None
1.42A22.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6MXT_A_K5YA1401_1
(ENDOLYSIN, BETA-2
ADRENERGIC RECEPTOR
CHIMERA)		1fq9 FIBROBLAST GROWTH
FACTOR 2
(Homo
sapiens)		3 / 3ASP A  90
SER A  87
SER A  85
None
0.63A16.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6MXT_A_K5YA1401_1
(ENDOLYSIN, BETA-2
ADRENERGIC RECEPTOR
CHIMERA)		1h6h NEUTROPHIL CYTOSOL
FACTOR 4
(Homo
sapiens)		3 / 3ASP A 126
SER A  79
SER A  77
None
0.83A15.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6MXT_A_K5YA1401_1
(ENDOLYSIN, BETA-2
ADRENERGIC RECEPTOR
CHIMERA)		2n04 DNAJ HOMOLOG
SUBFAMILY C MEMBER 5
(Homo
sapiens)		3 / 3ASP A  55
SER A  15
SER A  12
SEP  A  10 ( 3.7A)
None
SEP  A  10 ( 3.4A)
0.65A13.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6MXT_A_K5YA1401_1
(ENDOLYSIN, BETA-2
ADRENERGIC RECEPTOR
CHIMERA)		2odt INOSITOL-TETRAKISPHO
SPHATE 1-KINASE
(Homo
sapiens)		3 / 3ASP X 295
SER X 214
SER X 236
None
0.84A20.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6MXT_A_K5YA1401_1
(ENDOLYSIN, BETA-2
ADRENERGIC RECEPTOR
CHIMERA)		2pg6 CYTOCHROME P450 2A6
(Homo
sapiens)		3 / 3ASP A 169
SER A 175
SER A 307
None
0.73A21.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6MXT_A_K5YA1401_1
(ENDOLYSIN, BETA-2
ADRENERGIC RECEPTOR
CHIMERA)		2x4d PHOSPHOLYSINE
PHOSPHOHISTIDINE
INORGANIC
PYROPHOSPHATE
PHOSPHATASE
(Homo
sapiens)		3 / 3ASP A 168
SER A  25
SER A  19
None
None
POP  A 500 ( 3.9A)
0.83A21.11
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
6MXT_A_K5YA1401_1
(ENDOLYSIN, BETA-2
ADRENERGIC RECEPTOR
CHIMERA)		3pds FUSION PROTEIN
BETA-2 ADRENERGIC
RECEPTOR/LYSOZYME
(Homo
sapiens;
Escherichia
virus
T4)		3 / 3ASP A 113
SER A 203
SER A 207
ERC  A1201 (-3.7A)
ERC  A1201 (-2.8A)
ERC  A1201 (-2.7A)
0.48A57.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6MXT_A_K5YA1401_1
(ENDOLYSIN, BETA-2
ADRENERGIC RECEPTOR
CHIMERA)		4d86 POLY [ADP-RIBOSE]
POLYMERASE 14
(Homo
sapiens)		3 / 3ASP A1038
SER A1034
SER A1047
None
ADP  A1202 (-2.6A)
None
0.82A22.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6MXT_A_K5YA1401_1
(ENDOLYSIN, BETA-2
ADRENERGIC RECEPTOR
CHIMERA)		4fc7 PEROXISOMAL
2,4-DIENOYL-COA
REDUCTASE
(Homo
sapiens)		3 / 3ASP A  11
SER A  61
SER A  59
None
NAP  A 401 (-4.4A)
NAP  A 401 (-2.7A)
0.61A19.16
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
6MXT_A_K5YA1401_1
(ENDOLYSIN, BETA-2
ADRENERGIC RECEPTOR
CHIMERA)		4lde LYSOZYME, BETA-2
ADRENERGIC RECEPTOR
(Homo
sapiens;
Escherichia
virus
T4)		3 / 3ASP A1113
SER A1203
SER A1207
P0G  A1401 (-2.9A)
P0G  A1401 (-2.9A)
P0G  A1401 (-2.8A)
0.57A99.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6MXT_A_K5YA1401_1
(ENDOLYSIN, BETA-2
ADRENERGIC RECEPTOR
CHIMERA)		4rxx UBIQUITIN
CARBOXYL-TERMINAL
HYDROLASE 38
(Homo
sapiens)		3 / 3ASP A 259
SER A 225
SER A 266
None
0.80A22.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6MXT_A_K5YA1401_1
(ENDOLYSIN, BETA-2
ADRENERGIC RECEPTOR
CHIMERA)		4udb MINERALOCORTICOID
RECEPTOR
(Homo
sapiens)		3 / 3ASP A 937
SER A 808
SER A 811
None
SO4  A1986 ( 3.7A)
None
0.80A18.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6MXT_A_K5YA1401_1
(ENDOLYSIN, BETA-2
ADRENERGIC RECEPTOR
CHIMERA)		5gtm INTERFERON-INDUCED
GTP-BINDING PROTEIN
MX1
(Homo
sapiens)		3 / 3ASP A 377
SER A 617
SER A 620
None
0.67A22.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6MXT_A_K5YA1401_1
(ENDOLYSIN, BETA-2
ADRENERGIC RECEPTOR
CHIMERA)		5nug CYTOPLASMIC DYNEIN 1
HEAVY CHAIN 1
(Homo
sapiens)		3 / 3ASP A4050
SER A1969
SER A1972
None
0.78A7.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6MXT_A_K5YA1401_1
(ENDOLYSIN, BETA-2
ADRENERGIC RECEPTOR
CHIMERA)		6bfn INTERLEUKIN-1
RECEPTOR-ASSOCIATED
KINASE 1
(Homo
sapiens)		3 / 3ASP A 404
SER A 335
SER A 365
None
0.45Aundetectable