POTENTIAL TARGETS FROM HUMAN (RESULTS FROM SUB-STRUCTURAL SIMILARITY SEARCHES)
1) User may click on the DrReposER ID (the second column) to get information on the binding sites and drug molecule.
2) Click View (the second last column) to view matched residues and superposition in the NGL viewer (upper right part).
3) User may also click on the Dock (the last column) to get script for molecular docking in UCSF Chimera through AutoDock Vina.

DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Seq.
Identity (%)		 View Dock
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3HM1_A_J3ZA2_1
(ESTROGEN RECEPTOR)		1pcg ESTROGEN RECEPTOR
(Homo
sapiens)		10 / 12LEU A 346
THR A 347
ALA A 350
GLU A 353
LEU A 384
LEU A 387
LEU A 391
ARG A 394
MET A 421
LEU A 525
EST  A   1 (-4.4A)
None
EST  A   1 ( 3.7A)
EST  A   1 (-2.8A)
None
EST  A   1 (-4.0A)
EST  A   1 ( 3.9A)
EST  A   1 (-3.7A)
EST  A   1 ( 4.3A)
EST  A   1 (-3.6A)
0.45A98.36
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3HM1_A_J3ZA2_1
(ESTROGEN RECEPTOR)		1pcg ESTROGEN RECEPTOR
(Homo
sapiens)		7 / 12MET A 342
LEU A 346
ALA A 350
GLU A 353
LEU A 387
LEU A 391
ARG A 394
None
EST  A   1 (-4.4A)
EST  A   1 ( 3.7A)
EST  A   1 (-2.8A)
EST  A   1 (-4.0A)
EST  A   1 ( 3.9A)
EST  A   1 (-3.7A)
1.24A98.36
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3HM1_A_J3ZA2_1
(ESTROGEN RECEPTOR)		1pcg ESTROGEN RECEPTOR
(Homo
sapiens)		10 / 12MET A 343
LEU A 346
THR A 347
ALA A 350
GLU A 353
LEU A 384
LEU A 387
LEU A 391
ARG A 394
MET A 421
EST  A   1 ( 4.0A)
EST  A   1 (-4.4A)
None
EST  A   1 ( 3.7A)
EST  A   1 (-2.8A)
None
EST  A   1 (-4.0A)
EST  A   1 ( 3.9A)
EST  A   1 (-3.7A)
EST  A   1 ( 4.3A)
0.62A98.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HM1_A_J3ZA2_1
(ESTROGEN RECEPTOR)		1zkl HIGH-AFFINITY
CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 7A
(Homo
sapiens)		5 / 12LEU A 246
ALA A 250
LEU A 198
LEU A 170
LEU A 173
None
1.06A23.56
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3HM1_A_J3ZA2_1
(ESTROGEN RECEPTOR)		2gpv ESTROGEN-RELATED
RECEPTOR GAMMA
(Homo
sapiens)		5 / 12LEU A 268
ALA A 272
GLU A 275
LEU A 309
ARG A 316
OHT  A 500 (-4.1A)
OHT  A 500 (-3.5A)
OHT  A 500 (-2.6A)
OHT  A 500 ( 4.0A)
OHT  A 500 (-3.8A)
0.49A36.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HM1_A_J3ZA2_1
(ESTROGEN RECEPTOR)		2h8h PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC
(Homo
sapiens)		5 / 12THR A 456
LEU A 346
LEU A 347
LEU A 452
MET A 495
None
1.14A18.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HM1_A_J3ZA2_1
(ESTROGEN RECEPTOR)		2kr0 PROTEASOMAL
UBIQUITIN RECEPTOR
ADRM1
(Homo
sapiens)		5 / 12LEU A 347
ALA A 345
LEU A 310
LEU A 340
MET A 356
None
1.12A19.62
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3HM1_A_J3ZA2_1
(ESTROGEN RECEPTOR)		2ocf ESTROGEN RECEPTOR
(Homo
sapiens)		11 / 12MET A 343
LEU A 346
THR A 347
ALA A 350
GLU A 353
LEU A 384
LEU A 387
LEU A 391
ARG A 394
MET A 421
LEU A 525
EST  A 596 (-4.8A)
EST  A 596 (-4.4A)
None
EST  A 596 ( 3.9A)
EST  A 596 (-2.7A)
None
EST  A 596 ( 4.2A)
EST  A 596 ( 4.6A)
EST  A 596 (-4.0A)
EST  A 596 (-4.5A)
EST  A 596 (-3.6A)
0.47A100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HM1_A_J3ZA2_1
(ESTROGEN RECEPTOR)		2zns GLUTAMATE RECEPTOR,
IONOTROPIC KAINATE 1
(Homo
sapiens)		5 / 12LEU A 460
LEU A 452
LEU A 453
LEU A 497
LEU A 770
None
1.12A22.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HM1_A_J3ZA2_1
(ESTROGEN RECEPTOR)		3kn1 GOLGI PHOSPHOPROTEIN
3
(Homo
sapiens)		5 / 12LEU A 133
ALA A 136
GLU A 135
LEU A 170
LEU A  94
None
1.14A23.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HM1_A_J3ZA2_1
(ESTROGEN RECEPTOR)		3kq4 GASTRIC INTRINSIC
FACTOR
(Homo
sapiens)		5 / 12LEU A  94
THR A  95
ALA A  98
LEU A  75
LEU A  58
None
1.07A20.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HM1_A_J3ZA2_1
(ESTROGEN RECEPTOR)		4az3 LYSOSOMAL PROTECTIVE
PROTEIN 20 KDA CHAIN
LYSOSOMAL PROTECTIVE
PROTEIN 32 KDA CHAIN
(Homo
sapiens)		5 / 12THR B 306
ALA B 309
LEU A  67
LEU A  74
MET B 430
None
None
None
None
S35  A1259 ( 4.6A)
1.00A19.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HM1_A_J3ZA2_1
(ESTROGEN RECEPTOR)		4k11 PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC
(Homo
sapiens)		5 / 12THR A 456
LEU A 346
LEU A 347
LEU A 452
MET A 495
None
1.14A20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HM1_A_J3ZA2_1
(ESTROGEN RECEPTOR)		4mwt LYSOSOMAL PROTECTIVE
PROTEIN
(Homo
sapiens)		5 / 12THR A 306
ALA A 309
LEU A  67
LEU A  74
MET A 430
THR  A 306 ( 0.8A)
ALA  A 309 ( 0.0A)
LEU  A  67 ( 0.5A)
LEU  A  74 ( 0.6A)
MET  A 430 ( 0.0A)
1.16A20.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HM1_A_J3ZA2_1
(ESTROGEN RECEPTOR)		4po6 NON-RECEPTOR
TYROSINE-PROTEIN
KINASE TYK2
(Homo
sapiens)		5 / 12LEU A 263
THR A 262
ALA A 261
LEU A 152
LEU A 189
None
1.04A18.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HM1_A_J3ZA2_1
(ESTROGEN RECEPTOR)		4s3n 2'-5'-OLIGOADENYLATE
SYNTHASE 3
(Homo
sapiens)		5 / 12LEU A 232
THR A 233
ALA A 236
LEU A 345
LEU A 353
None
1.06A21.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HM1_A_J3ZA2_1
(ESTROGEN RECEPTOR)		4u2x IMPORTIN SUBUNIT
ALPHA-6
(Homo
sapiens)		5 / 12LEU D 479
LEU D 445
LEU D 448
LEU D 452
LEU D 485
None
1.02A19.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HM1_A_J3ZA2_1
(ESTROGEN RECEPTOR)		4uad IMPORTIN SUBUNIT
ALPHA-7
(Homo
sapiens)		5 / 12LEU A 476
LEU A 442
LEU A 445
LEU A 449
LEU A 482
None
1.00A20.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HM1_A_J3ZA2_1
(ESTROGEN RECEPTOR)		4udb MINERALOCORTICOID
RECEPTOR
(Homo
sapiens)		5 / 12LEU A 769
ALA A 773
LEU A 810
LEU A 814
ARG A 817
CV7  A1987 (-4.1A)
CV7  A1987 (-3.5A)
CV7  A1987 (-4.0A)
CV7  A1987 ( 4.0A)
CV7  A1987 (-3.7A)
0.48A27.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HM1_A_J3ZA2_1
(ESTROGEN RECEPTOR)		4ylq COAGULATION FACTOR
VII
(Homo
sapiens)		5 / 12LEU H  46
THR H  45
LEU H 105
LEU H 106
LEU H 108
None
1.09A20.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HM1_A_J3ZA2_1
(ESTROGEN RECEPTOR)		4zfh ARTIFICIAL ANKYRIN
REPEAT
PROTEIN_ANK(GAG)1D4
MUTANT -Y56A
(Homo
sapiens)		5 / 12LEU A  19
ALA A  21
LEU A  34
LEU A  33
LEU A  66
None
1.14A24.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HM1_A_J3ZA2_1
(ESTROGEN RECEPTOR)		5hvv MACROPHAGE MIGRATION
INHIBITORY FACTOR
(Homo
sapiens)		5 / 12THR A  30
ALA A  29
LEU A  79
LEU A  78
LEU A  61
None
1.13A16.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HM1_A_J3ZA2_1
(ESTROGEN RECEPTOR)		5ixd TYROSINE-PROTEIN
KINASE JAK1
(Homo
sapiens)		5 / 12LEU A 274
THR A 273
ALA A 272
LEU A 158
LEU A 195
None
1.06A18.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HM1_A_J3ZA2_1
(ESTROGEN RECEPTOR)		5mwp MINERALOCORTICOID
RECEPTOR
(Homo
sapiens)		5 / 12LEU A 769
ALA A 773
LEU A 814
ARG A 817
MET A 845
ECV  A1101 (-4.7A)
ECV  A1101 (-3.8A)
ECV  A1101 (-4.1A)
ECV  A1101 (-4.0A)
ECV  A1101 (-4.0A)
0.48A14.04
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3HM1_A_J3ZA2_1
(ESTROGEN RECEPTOR)		5toa ESTROGEN RECEPTOR
BETA
(Homo
sapiens)		8 / 12LEU A 298
THR A 299
ALA A 302
GLU A 305
LEU A 339
LEU A 343
ARG A 346
LEU A 476
EST  A 601 (-4.1A)
None
EST  A 601 ( 3.9A)
EST  A 601 (-2.4A)
EST  A 601 (-3.9A)
EST  A 601 ( 4.4A)
EST  A 601 (-4.1A)
EST  A 601 (-3.5A)
0.44A57.48
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3HM1_A_J3ZA2_1
(ESTROGEN RECEPTOR)		5toa ESTROGEN RECEPTOR
BETA
(Homo
sapiens)		8 / 12MET A 295
LEU A 298
THR A 299
ALA A 302
GLU A 305
LEU A 339
LEU A 343
ARG A 346
EST  A 601 ( 4.4A)
EST  A 601 (-4.1A)
None
EST  A 601 ( 3.9A)
EST  A 601 (-2.4A)
EST  A 601 (-3.9A)
EST  A 601 ( 4.4A)
EST  A 601 (-4.1A)
0.47A57.48
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3HM1_B_J3ZB1_1
(ESTROGEN RECEPTOR)		1pcg ESTROGEN RECEPTOR
(Homo
sapiens)		11 / 11MET A 343
LEU A 346
LEU A 349
GLU A 353
MET A 388
LEU A 391
ARG A 394
MET A 421
GLY A 521
HIS A 524
LEU A 525
EST  A   1 ( 4.0A)
EST  A   1 (-4.4A)
EST  A   1 ( 4.8A)
EST  A   1 (-2.8A)
None
EST  A   1 ( 3.9A)
EST  A   1 (-3.7A)
EST  A   1 ( 4.3A)
EST  A   1 ( 4.1A)
EST  A   1 (-3.8A)
EST  A   1 (-3.6A)
0.42A98.36
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3HM1_B_J3ZB1_1
(ESTROGEN RECEPTOR)		1pcg ESTROGEN RECEPTOR
(Homo
sapiens)		5 / 11MET A 343
LEU A 346
LEU A 402
HIS A 524
LEU A 525
EST  A   1 ( 4.0A)
EST  A   1 (-4.4A)
None
EST  A   1 (-3.8A)
EST  A   1 (-3.6A)
1.35A98.36
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3HM1_B_J3ZB1_1
(ESTROGEN RECEPTOR)		1xb7 STEROID HORMONE
RECEPTOR ERR1
(Homo
sapiens)		5 / 11LEU A 324
LEU A 327
GLU A 331
ARG A 372
HIS A 494
None
0.58A32.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HM1_B_J3ZB1_1
(ESTROGEN RECEPTOR)		2clp AFLATOXIN B1
ALDEHYDE REDUCTASE
MEMBER 3
(Homo
sapiens)		5 / 11LEU A 350
GLU A 272
MET A 292
GLY A 236
LEU A 233
None
CA  A1362 (-4.3A)
None
None
None
1.38A21.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HM1_B_J3ZB1_1
(ESTROGEN RECEPTOR)		2gf5 FADD PROTEIN
(Homo
sapiens)		5 / 11LEU A   8
LEU A   7
LEU A  67
GLY A  42
LEU A  43
None
1.28A24.51
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3HM1_B_J3ZB1_1
(ESTROGEN RECEPTOR)		2gpv ESTROGEN-RELATED
RECEPTOR GAMMA
(Homo
sapiens)		5 / 11LEU A 268
LEU A 271
GLU A 275
ARG A 316
HIS A 434
OHT  A 500 (-4.1A)
OHT  A 500 ( 4.4A)
OHT  A 500 (-2.6A)
OHT  A 500 (-3.8A)
OHT  A 500 ( 4.7A)
0.52A36.29
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3HM1_B_J3ZB1_1
(ESTROGEN RECEPTOR)		2ocf ESTROGEN RECEPTOR
(Homo
sapiens)		11 / 11MET A 343
LEU A 346
LEU A 349
GLU A 353
MET A 388
LEU A 391
ARG A 394
MET A 421
GLY A 521
HIS A 524
LEU A 525
EST  A 596 (-4.8A)
EST  A 596 (-4.4A)
EST  A 596 ( 4.1A)
EST  A 596 (-2.7A)
None
EST  A 596 ( 4.6A)
EST  A 596 (-4.0A)
EST  A 596 (-4.5A)
EST  A 596 ( 4.0A)
EST  A 596 (-4.2A)
EST  A 596 (-3.6A)
0.44A100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3HM1_B_J3ZB1_1
(ESTROGEN RECEPTOR)		2ocf ESTROGEN RECEPTOR
(Homo
sapiens)		6 / 11MET A 343
LEU A 346
LEU A 402
GLY A 521
HIS A 524
LEU A 525
EST  A 596 (-4.8A)
EST  A 596 (-4.4A)
None
EST  A 596 ( 4.0A)
EST  A 596 (-4.2A)
EST  A 596 (-3.6A)
1.29A100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HM1_B_J3ZB1_1
(ESTROGEN RECEPTOR)		3e7o MITOGEN-ACTIVATED
PROTEIN KINASE 9
(Homo
sapiens)		5 / 11LEU A 115
LEU A 165
MET A 128
LEU A 132
HIS A 120
None
1.24A20.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HM1_B_J3ZB1_1
(ESTROGEN RECEPTOR)		3zzz POLYPYRIMIDINE
TRACT-BINDING
PROTEIN 1
(Homo
sapiens)		5 / 11LEU A 241
LEU A 253
LEU A 226
HIS A 236
LEU A 239
None
1.31A19.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HM1_B_J3ZB1_1
(ESTROGEN RECEPTOR)		4b3g DNA-BINDING PROTEIN
SMUBP-2
(Homo
sapiens)		5 / 11LEU A 389
GLU A 382
MET A 423
LEU A 426
ARG A 425
None
1.33A17.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HM1_B_J3ZB1_1
(ESTROGEN RECEPTOR)		4uhi STEROL 14-ALPHA
DEMETHYLASE
(Homo
sapiens)		5 / 11LEU A 305
LEU A 286
ARG A 272
GLY A 162
LEU A 159
None
None
None
None
VFV  A 580 (-4.5A)
1.05A21.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HM1_B_J3ZB1_1
(ESTROGEN RECEPTOR)		4ye9 GLUTAMINE--TRNA
LIGASE
(Homo
sapiens)		5 / 11MET A 221
LEU A 224
LEU A 229
LEU A 455
GLY A 296
None
1.32A16.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HM1_B_J3ZB1_1
(ESTROGEN RECEPTOR)		5a3f DYNAMIN 3
(Homo
sapiens)		5 / 11LEU A  69
LEU A  71
LEU A  57
GLY A 139
LEU A 137
None
1.33A15.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HM1_B_J3ZB1_1
(ESTROGEN RECEPTOR)		5gk9 BRD1 PROTEIN
HISTONE
ACETYLTRANSFERASE
KAT7
(Homo
sapiens)		5 / 11MET A 564
LEU A 575
LEU A 573
GLU B  58
LEU A 531
None
1.05A21.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HM1_B_J3ZB1_1
(ESTROGEN RECEPTOR)		5gvb WD REPEAT AND
HMG-BOX DNA-BINDING
PROTEIN 1
(Homo
sapiens)		5 / 11LEU A 604
LEU A 554
GLY A 616
HIS A 615
LEU A 614
None
1.32A20.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HM1_B_J3ZB1_1
(ESTROGEN RECEPTOR)		5gvb WD REPEAT AND
HMG-BOX DNA-BINDING
PROTEIN 1
(Homo
sapiens)		5 / 11LEU A 604
LEU A 569
GLY A 616
HIS A 615
LEU A 614
None
1.31A20.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HM1_B_J3ZB1_1
(ESTROGEN RECEPTOR)		5ja4 TONSOKU-LIKE PROTEIN
(Homo
sapiens)		5 / 11LEU D 617
LEU D 618
LEU D 606
GLY D 573
LEU D 575
None
1.29A21.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HM1_B_J3ZB1_1
(ESTROGEN RECEPTOR)		5mwp MINERALOCORTICOID
RECEPTOR
(Homo
sapiens)		5 / 11LEU A 769
LEU A 772
LEU A 814
ARG A 817
MET A 845
ECV  A1101 (-4.7A)
ECV  A1101 ( 3.9A)
ECV  A1101 (-4.1A)
ECV  A1101 (-4.0A)
ECV  A1101 (-4.0A)
0.41A14.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HM1_B_J3ZB1_1
(ESTROGEN RECEPTOR)		5ogs WD REPEAT AND
HMG-BOX DNA-BINDING
PROTEIN 1
(Homo
sapiens)		5 / 11LEU A 604
LEU A 554
GLY A 616
HIS A 615
LEU A 614
None
1.35A19.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HM1_B_J3ZB1_1
(ESTROGEN RECEPTOR)		5ogs WD REPEAT AND
HMG-BOX DNA-BINDING
PROTEIN 1
(Homo
sapiens)		5 / 11LEU A 604
LEU A 569
GLY A 616
HIS A 615
LEU A 614
None
1.28A19.68
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3HM1_B_J3ZB1_1
(ESTROGEN RECEPTOR)		5toa ESTROGEN RECEPTOR
BETA
(Homo
sapiens)		7 / 11MET A 294
LEU A 298
LEU A 301
GLU A 305
MET A 340
LEU A 343
ARG A 346
None
EST  A 601 (-4.1A)
EST  A 601 ( 4.3A)
EST  A 601 (-2.4A)
EST  A 601 ( 4.8A)
EST  A 601 ( 4.4A)
EST  A 601 (-4.1A)
1.41A57.48
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3HM1_B_J3ZB1_1
(ESTROGEN RECEPTOR)		5toa ESTROGEN RECEPTOR
BETA
(Homo
sapiens)		10 / 11MET A 295
LEU A 298
LEU A 301
GLU A 305
MET A 340
LEU A 343
ARG A 346
GLY A 472
HIS A 475
LEU A 476
EST  A 601 ( 4.4A)
EST  A 601 (-4.1A)
EST  A 601 ( 4.3A)
EST  A 601 (-2.4A)
EST  A 601 ( 4.8A)
EST  A 601 ( 4.4A)
EST  A 601 (-4.1A)
EST  A 601 (-4.0A)
EST  A 601 (-4.4A)
EST  A 601 (-3.5A)
0.38A57.48
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3HM1_B_J3ZB1_1
(ESTROGEN RECEPTOR)		5toa ESTROGEN RECEPTOR
BETA
(Homo
sapiens)		6 / 11MET A 295
LEU A 298
LEU A 354
GLY A 472
HIS A 475
LEU A 476
EST  A 601 ( 4.4A)
EST  A 601 (-4.1A)
None
EST  A 601 (-4.0A)
EST  A 601 (-4.4A)
EST  A 601 (-3.5A)
1.32A57.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HM1_B_J3ZB1_1
(ESTROGEN RECEPTOR)		5vcx MEMBRANE-ASSOCIATED
TYROSINE- AND
THREONINE-SPECIFIC
CDC2-INHIBITORY
KINASE
(Homo
sapiens)		5 / 11LEU A 232
LEU A 254
GLY A 228
HIS A 225
LEU A 224
None
1.27A22.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HM1_B_J3ZB1_1
(ESTROGEN RECEPTOR)		5wcj METHYLTRANSFERASE-LI
KE PROTEIN 13
(Homo
sapiens)		5 / 11LEU A 613
LEU A 615
GLU A 648
LEU A 637
GLY A 480
None
1.30A22.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HM1_B_J3ZB1_1
(ESTROGEN RECEPTOR)		5xf7 PROTEIN
DISULFIDE-ISOMERASE-
LIKE PROTEIN OF THE
TESTIS
(Homo
sapiens)		5 / 11LEU A 341
MET A 278
LEU A 279
GLY A 363
LEU A 367
None
1.34A17.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HM1_B_J3ZB1_1
(ESTROGEN RECEPTOR)		5y3r DNA-DEPENDENT
PROTEIN KINASE
CATALYTIC SUBUNIT
(Homo
sapiens)		5 / 11MET C1403
LEU C1406
MET C1369
HIS C1418
LEU C1419
None
1.18A5.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HS6_A_J3ZA302_1
(17-BETA-HYDROXYSTERO
ID DEHYDROGENASE 14)		2ipj ALDO-KETO REDUCTASE
FAMILY 1 MEMBER C2
(Homo
sapiens)		4 / 8TYR A  81
LEU A 103
LEU A  99
MET A 151
None
1.17A21.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HS6_A_J3ZA302_1
(17-BETA-HYDROXYSTERO
ID DEHYDROGENASE 14)		2mbg RALA-BINDING PROTEIN
1
(Homo
sapiens)		4 / 8HIS A 413
GLN A 417
LEU A 409
LEU A 429
None
1.06A22.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HS6_A_J3ZA302_1
(17-BETA-HYDROXYSTERO
ID DEHYDROGENASE 14)		2pvc DNA
(CYTOSINE-5)-METHYLT
RANSFERASE 3-LIKE
(Homo
sapiens)		4 / 8HIS B 264
GLN B 268
LEU B 260
LEU B 302
None
1.14A19.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HS6_A_J3ZA302_1
(17-BETA-HYDROXYSTERO
ID DEHYDROGENASE 14)		3ksy SON OF SEVENLESS
HOMOLOG 1
(Homo
sapiens)		4 / 8GLN A 975
LEU A 821
LEU A 804
THR A 629
None
1.05A12.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HS6_A_J3ZA302_1
(17-BETA-HYDROXYSTERO
ID DEHYDROGENASE 14)		3r6n DESMOPLAKIN
(Homo
sapiens)		4 / 8LEU A 536
TRP A 537
LEU A 540
MET A 544
None
0.94A19.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HS6_A_J3ZA302_1
(17-BETA-HYDROXYSTERO
ID DEHYDROGENASE 14)		4k6j WINGS APART-LIKE
PROTEIN HOMOLOG
(Homo
sapiens)		4 / 8LEU A 750
LEU A 747
MET A 724
THR A 798
None
1.12A19.11
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5HS6_A_J3ZA302_1
(17-BETA-HYDROXYSTERO
ID DEHYDROGENASE 14)		5en4 17-BETA-HYDROXYSTERO
ID DEHYDROGENASE 14
(Homo
sapiens)		8 / 8HIS A  93
GLN A 148
TYR A 154
LEU A 191
TRP A 192
LEU A 195
MET A 199
THR A 205
5Q6  A 302 (-3.5A)
5Q6  A 302 (-3.6A)
5Q6  A 302 ( 4.3A)
NAD  A 301 (-3.6A)
5Q6  A 302 ( 3.3A)
5Q6  A 302 (-4.1A)
None
None
0.33A100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HS6_A_J3ZA302_1
(17-BETA-HYDROXYSTERO
ID DEHYDROGENASE 14)		5j1f PLECTIN,PLECTIN
(Homo
sapiens)		4 / 8LEU A 909
TRP A 910
LEU A 913
MET A 917
None
1.10A23.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HS6_A_J3ZA302_1
(17-BETA-HYDROXYSTERO
ID DEHYDROGENASE 14)		5l3x NEGATIVE ELONGATION
FACTOR C/D
(Homo
sapiens)		4 / 8GLN B 442
TYR B 440
LEU B 492
LEU B 484
None
0.94A19.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HS6_A_J3ZA302_1
(17-BETA-HYDROXYSTERO
ID DEHYDROGENASE 14)		5nh1 GASDERMIN-D
(Homo
sapiens)		4 / 8HIS A 386
GLN A 323
LEU A 389
LEU A 320
None
1.16A23.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HS6_A_J3ZA302_1
(17-BETA-HYDROXYSTERO
ID DEHYDROGENASE 14)		5nug CYTOPLASMIC DYNEIN 1
HEAVY CHAIN 1
(Homo
sapiens)		4 / 8TYR A3586
LEU A3627
LEU A3623
THR A3612
None
1.13A4.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HS6_A_J3ZA302_1
(17-BETA-HYDROXYSTERO
ID DEHYDROGENASE 14)		5txk UBIQUITIN
CARBOXYL-TERMINAL
HYDROLASE
35,UBIQUITIN
CARBOXYL-TERMINAL
HYDROLASE 35
(Homo
sapiens)		4 / 8TYR A 527
LEU A 480
LEU A 532
THR A 564
None
1.02A15.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HS6_A_J3ZA302_1
(17-BETA-HYDROXYSTERO
ID DEHYDROGENASE 14)		6ez8 HUNTINGTIN
(Homo
sapiens)		4 / 8LEU A 958
LEU A1828
MET A1821
THR A1824
None
1.14A12.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HS6_A_J3ZA302_1
(17-BETA-HYDROXYSTERO
ID DEHYDROGENASE 14)		6f2u ALDO-KETO REDUCTASE
FAMILY 1 MEMBER C3
(Homo
sapiens)		4 / 8TYR A  81
LEU A 103
LEU A  99
MET A 151
None
1.11A15.93