POTENTIAL TARGETS FROM HUMAN (RESULTS FROM SUB-STRUCTURAL SIMILARITY SEARCHES)
1) User may click on the DrReposER ID (the second column) to get information on the binding sites and drug molecule.
2) Click View (the second last column) to view matched residues and superposition in the NGL viewer (upper right part).
3) User may also click on the Dock (the last column) to get script for molecular docking in UCSF Chimera through AutoDock Vina.

DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Seq.
Identity (%)		 View Dock
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3P6G_A_IZPA133_1
(FATTY ACID-BINDING
PROTEIN, ADIPOCYTE)		1jjx BRAIN-TYPE FATTY
ACID BINDING PROTEIN
(Homo
sapiens)		6 / 12MET A  20
VAL A  25
PRO A  38
ASP A  76
ARG A  78
TYR A 128
None
1.22A56.49
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3P6G_A_IZPA133_1
(FATTY ACID-BINDING
PROTEIN, ADIPOCYTE)		1jjx BRAIN-TYPE FATTY
ACID BINDING PROTEIN
(Homo
sapiens)		5 / 12PHE A  16
MET A  20
VAL A  25
ARG A  78
TYR A 128
None
1.05A56.49
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3P6G_A_IZPA133_1
(FATTY ACID-BINDING
PROTEIN, ADIPOCYTE)		1tow FATTY ACID-BINDING
PROTEIN, ADIPOCYTE
(Homo
sapiens)		12 / 12PHE A  16
MET A  20
VAL A  25
PRO A  38
ASP A  76
ARG A  78
ILE A 104
ARG A 106
VAL A 115
CYH A 117
ARG A 126
TYR A 128
CRZ  A 501 (-4.5A)
CRZ  A 501 ( 3.8A)
None
CRZ  A 501 (-4.5A)
CRZ  A 501 (-4.0A)
CRZ  A 501 (-4.7A)
CRZ  A 501 ( 4.8A)
None
None
CRZ  A 501 ( 3.8A)
CRZ  A 501 (-3.8A)
CRZ  A 501 (-4.8A)
0.43A100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3P6G_A_IZPA133_1
(FATTY ACID-BINDING
PROTEIN, ADIPOCYTE)		1tow FATTY ACID-BINDING
PROTEIN, ADIPOCYTE
(Homo
sapiens)		5 / 12PHE A  16
VAL A  23
PRO A  38
ARG A 126
TYR A 128
CRZ  A 501 (-4.5A)
None
CRZ  A 501 (-4.5A)
CRZ  A 501 (-3.8A)
CRZ  A 501 (-4.8A)
1.19A100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3P6G_A_IZPA133_1
(FATTY ACID-BINDING
PROTEIN, ADIPOCYTE)		2can ORNITHINE
AMINOTRANSFERASE
(Homo
sapiens)		5 / 12PHE A  44
VAL A  73
PRO A  57
ASP A  72
ARG A  76
None
1.38A17.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3P6G_A_IZPA133_1
(FATTY ACID-BINDING
PROTEIN, ADIPOCYTE)		3ll8 SERINE/THREONINE-PRO
TEIN PHOSPHATASE 2B
CATALYTIC SUBUNIT
ALPHA ISOFORM
(Homo
sapiens)		5 / 12PHE A 162
ILE A  65
VAL A 174
CYH A 178
TYR A 170
None
1.34A15.97
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3P6G_A_IZPA133_1
(FATTY ACID-BINDING
PROTEIN, ADIPOCYTE)		3nr3 PMP2 PROTEIN
(Homo
sapiens)		11 / 12PHE A  17
MET A  21
VAL A  26
PRO A  39
ASP A  77
ARG A  79
ILE A 105
ARG A 107
CYH A 118
ARG A 127
TYR A 129
None
PLM  A 901 (-3.7A)
None
SO4  A 903 ( 4.8A)
PLM  A 901 (-4.0A)
None
PLM  A 901 ( 4.5A)
PLM  A 901 (-3.7A)
PLM  A 901 ( 3.8A)
PLM  A 901 (-4.6A)
PLM  A 901 (-4.6A)
0.58A58.17
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3P6G_A_IZPA133_1
(FATTY ACID-BINDING
PROTEIN, ADIPOCYTE)		3nr3 PMP2 PROTEIN
(Homo
sapiens)		8 / 12PHE A  17
MET A  21
VAL A  26
PRO A  39
ASP A  77
CYH A 125
ARG A 127
TYR A 129
None
PLM  A 901 (-3.7A)
None
SO4  A 903 ( 4.8A)
PLM  A 901 (-4.0A)
None
PLM  A 901 (-4.6A)
PLM  A 901 (-4.6A)
1.17A58.17
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3P6G_A_IZPA133_1
(FATTY ACID-BINDING
PROTEIN, ADIPOCYTE)		3wbg FATTY ACID-BINDING
PROTEIN, HEART
(Homo
sapiens)		9 / 12PHE A  16
MET A  20
VAL A  25
PRO A  38
ASP A  76
ARG A  78
ARG A 106
ARG A 126
TYR A 128
2AN  A 201 ( 4.9A)
2AN  A 201 ( 3.9A)
None
2AN  A 201 ( 4.3A)
2AN  A 201 (-3.9A)
2AN  A 201 ( 4.8A)
None
2AN  A 201 ( 4.9A)
None
0.72A59.48
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3P6G_A_IZPA133_1
(FATTY ACID-BINDING
PROTEIN, ADIPOCYTE)		3wbg FATTY ACID-BINDING
PROTEIN, HEART
(Homo
sapiens)		8 / 12PHE A  16
MET A  20
VAL A  25
PRO A  38
ASP A  76
CYH A 124
ARG A 126
TYR A 128
2AN  A 201 ( 4.9A)
2AN  A 201 ( 3.9A)
None
2AN  A 201 ( 4.3A)
2AN  A 201 (-3.9A)
None
2AN  A 201 ( 4.9A)
None
1.16A59.48
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3P6G_A_IZPA133_1
(FATTY ACID-BINDING
PROTEIN, ADIPOCYTE)		4a60 FATTY ACID-BINDING
PROTEIN 9 TESTIS
LIPID-BINDING
PROTEIN, TLBP,
TESTIS-TYPE FATTY
ACID-BINDING
PROTEIN, T-FABP
(Homo
sapiens)		10 / 12MET A  21
VAL A  26
PRO A  39
ASP A  77
ARG A  79
ARG A 107
VAL A 116
CYH A 118
ARG A 127
TYR A 129
EDO  A1134 (-4.5A)
None
None
EDO  A1134 (-3.7A)
EDO  A1134 ( 4.9A)
None
None
None
None
None
0.78A56.49
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3P6G_A_IZPA133_1
(FATTY ACID-BINDING
PROTEIN, ADIPOCYTE)		4a60 FATTY ACID-BINDING
PROTEIN 9 TESTIS
LIPID-BINDING
PROTEIN, TLBP,
TESTIS-TYPE FATTY
ACID-BINDING
PROTEIN, T-FABP
(Homo
sapiens)		10 / 12MET A  21
VAL A  26
PRO A  39
ASP A  77
ARG A  79
ILE A 105
VAL A 116
CYH A 118
ARG A 127
TYR A 129
EDO  A1134 (-4.5A)
None
None
EDO  A1134 (-3.7A)
EDO  A1134 ( 4.9A)
None
None
None
None
None
0.71A56.49
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3P6G_A_IZPA133_1
(FATTY ACID-BINDING
PROTEIN, ADIPOCYTE)		4a60 FATTY ACID-BINDING
PROTEIN 9 TESTIS
LIPID-BINDING
PROTEIN, TLBP,
TESTIS-TYPE FATTY
ACID-BINDING
PROTEIN, T-FABP
(Homo
sapiens)		9 / 12PHE A  17
MET A  21
VAL A  26
PRO A  39
ASP A  77
ARG A  79
ARG A 107
ARG A 127
TYR A 129
None
EDO  A1134 (-4.5A)
None
None
EDO  A1134 (-3.7A)
EDO  A1134 ( 4.9A)
None
None
None
0.86A56.49
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3P6G_A_IZPA133_1
(FATTY ACID-BINDING
PROTEIN, ADIPOCYTE)		4a60 FATTY ACID-BINDING
PROTEIN 9 TESTIS
LIPID-BINDING
PROTEIN, TLBP,
TESTIS-TYPE FATTY
ACID-BINDING
PROTEIN, T-FABP
(Homo
sapiens)		9 / 12PHE A  17
MET A  21
VAL A  26
PRO A  39
ASP A  77
ARG A  79
ILE A 105
ARG A 127
TYR A 129
None
EDO  A1134 (-4.5A)
None
None
EDO  A1134 (-3.7A)
EDO  A1134 ( 4.9A)
None
None
None
0.83A56.49
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3P6G_A_IZPA133_1
(FATTY ACID-BINDING
PROTEIN, ADIPOCYTE)		4nns FATTY ACID-BINDING
PROTEIN, ADIPOCYTE
(Homo
sapiens)		12 / 12PHE A  16
MET A  20
VAL A  25
PRO A  38
ASP A  76
ARG A  78
ILE A 104
ARG A 106
VAL A 115
CYH A 117
ARG A 126
TYR A 128
None
75D  A 201 (-3.6A)
None
75D  A 201 (-4.4A)
75D  A 201 (-4.1A)
75D  A 201 (-4.7A)
75D  A 201 ( 4.4A)
75D  A 201 ( 4.6A)
None
75D  A 201 (-3.5A)
75D  A 201 (-3.9A)
None
0.39A90.13
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3P6G_A_IZPA133_1
(FATTY ACID-BINDING
PROTEIN, ADIPOCYTE)		4nns FATTY ACID-BINDING
PROTEIN, ADIPOCYTE
(Homo
sapiens)		5 / 12PHE A  16
VAL A  23
PRO A  38
ARG A 126
TYR A 128
None
None
75D  A 201 (-4.4A)
75D  A 201 (-3.9A)
None
1.25A90.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3P6G_A_IZPA133_1
(FATTY ACID-BINDING
PROTEIN, ADIPOCYTE)		4ora SERINE/THREONINE-PRO
TEIN PHOSPHATASE 2B
CATALYTIC SUBUNIT
BETA ISOFORM
(Homo
sapiens)		5 / 12PHE A 171
ILE A  74
VAL A 183
CYH A 187
TYR A 179
None
1.28A15.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3P6G_A_IZPA133_1
(FATTY ACID-BINDING
PROTEIN, ADIPOCYTE)		4zg7 ECTONUCLEOTIDE
PYROPHOSPHATASE/PHOS
PHODIESTERASE FAMILY
MEMBER 2
(Homo
sapiens)		5 / 12VAL A 816
PRO A 683
ILE A 772
VAL A 733
TYR A 634
None
None
GOL  A 915 ( 4.6A)
None
None
1.37A9.90
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3P6G_A_IZPA133_1
(FATTY ACID-BINDING
PROTEIN, ADIPOCYTE)		5b29 FATTY ACID-BINDING
PROTEIN, HEART
(Homo
sapiens)		8 / 12MET A  20
VAL A  25
PRO A  38
ASP A  76
ARG A  78
ARG A 106
ARG A 126
TYR A 128
PLM  A 200 ( 4.0A)
None
PLM  A 200 ( 4.9A)
PLM  A 200 ( 4.3A)
None
None
PLM  A 200 (-3.7A)
PLM  A 200 (-4.8A)
0.60A60.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3P6G_A_IZPA133_1
(FATTY ACID-BINDING
PROTEIN, ADIPOCYTE)		5b29 FATTY ACID-BINDING
PROTEIN, HEART
(Homo
sapiens)		7 / 12MET A  20
VAL A  25
PRO A  38
ASP A  76
CYH A 124
ARG A 126
TYR A 128
PLM  A 200 ( 4.0A)
None
PLM  A 200 ( 4.9A)
PLM  A 200 ( 4.3A)
None
PLM  A 200 (-3.7A)
PLM  A 200 (-4.8A)
1.14A60.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3P6G_A_IZPA133_1
(FATTY ACID-BINDING
PROTEIN, ADIPOCYTE)		5hz5 FATTY ACID-BINDING
PROTEIN, EPIDERMAL
(Homo
sapiens)		11 / 12PHE A  19
MET A  23
VAL A  28
PRO A  41
ASP A  79
ARG A  81
ILE A 107
ARG A 109
VAL A 118
ARG A 129
TYR A 131
65X  A 203 ( 4.7A)
65X  A 203 ( 3.9A)
None
65X  A 203 (-4.4A)
65X  A 203 ( 4.2A)
None
65X  A 203 (-3.9A)
65X  A 203 (-4.0A)
None
65X  A 203 (-3.9A)
None
0.58A51.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3P6G_A_IZPA133_1
(FATTY ACID-BINDING
PROTEIN, ADIPOCYTE)		5i6v TYROSINE-PROTEIN
PHOSPHATASE
NON-RECEPTOR TYPE 11
(Homo
sapiens)		5 / 12MET A 355
PRO A 372
VAL A 338
CYH A 333
TYR A 380
None
1.49A13.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3P6G_A_IZPA133_1
(FATTY ACID-BINDING
PROTEIN, ADIPOCYTE)		5xtc NADH DEHYDROGENASE
[UBIQUINONE] 1
SUBUNIT C2
(Homo
sapiens)		5 / 12PRO g  21
ASP g  86
ARG g  85
ARG g  29
VAL g  75
None
1.44A16.30
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3R8G_A_IZPA409_1
(ALDO-KETO REDUCTASE
FAMILY 1 MEMBER C3)		2fvl ALDO-KETO REDUCTASE
FAMILY 1, MEMBER C4
(Homo
sapiens)		6 / 9LEU A  54
TYR A  55
HIS A 117
MET A 120
ASN A 167
PRO A 318
None
NAP  A1001 (-4.7A)
NAP  A1001 (-4.4A)
None
NAP  A1001 (-3.1A)
None
0.46A84.21
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3R8G_A_IZPA409_1
(ALDO-KETO REDUCTASE
FAMILY 1 MEMBER C3)		2ipj ALDO-KETO REDUCTASE
FAMILY 1 MEMBER C2
(Homo
sapiens)		5 / 9TYR A  55
HIS A 117
ASN A 167
TYR A 216
PRO A 318
FFA  A 325 ( 4.3A)
FFA  A 325 ( 3.8A)
NAP  A   1 (-3.1A)
NAP  A   1 (-3.2A)
None
0.32A86.60
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3R8G_A_IZPA409_1
(ALDO-KETO REDUCTASE
FAMILY 1 MEMBER C3)		2is7 ALDOSE REDUCTASE
(Homo
sapiens)		5 / 9TYR A  48
HIS A 110
ASN A 160
TYR A 209
PRO A 310
2CL  A 317 ( 4.5A)
2CL  A 317 ( 3.8A)
NAP  A 316 (-3.4A)
NAP  A 316 (-3.2A)
None
0.42A48.15
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3R8G_A_IZPA409_1
(ALDO-KETO REDUCTASE
FAMILY 1 MEMBER C3)		3cav 3-OXO-5-BETA-STEROID
4-DEHYDROGENASE
(Homo
sapiens)		5 / 9TYR A  58
MET A 123
ASN A 170
TYR A 219
PRO A 321
CI2  A 328 ( 4.5A)
None
NAP  A 327 (-3.6A)
NAP  A 327 (-3.4A)
None
0.48A55.52
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3R8G_A_IZPA409_1
(ALDO-KETO REDUCTASE
FAMILY 1 MEMBER C3)		5liy ALDO-KETO REDUCTASE
FAMILY 1 MEMBER B10
(Homo
sapiens)		5 / 9TYR X  49
HIS X 111
ASN X 161
TYR X 210
PRO X 311
DQP  X 402 ( 4.0A)
DQP  X 402 ( 4.1A)
NAP  X 401 (-3.2A)
NAP  X 401 ( 3.1A)
None
0.43A46.75
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3R8G_A_IZPA409_1
(ALDO-KETO REDUCTASE
FAMILY 1 MEMBER C3)		6f2u ALDO-KETO REDUCTASE
FAMILY 1 MEMBER C3
(Homo
sapiens)		6 / 9LEU A  54
TYR A  55
HIS A 117
ASN A 167
PHE A 306
PRO A 318
None
CJ2  A 402 ( 4.1A)
CJ2  A 402 ( 3.8A)
NAP  A 401 ( 3.3A)
CJ2  A 402 (-3.8A)
None
1.06A100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3R8G_A_IZPA409_1
(ALDO-KETO REDUCTASE
FAMILY 1 MEMBER C3)		6f2u ALDO-KETO REDUCTASE
FAMILY 1 MEMBER C3
(Homo
sapiens)		7 / 9LEU A  54
TYR A  55
HIS A 117
MET A 120
ASN A 167
TYR A 216
PRO A 318
None
CJ2  A 402 ( 4.1A)
CJ2  A 402 ( 3.8A)
CJ2  A 402 ( 4.7A)
NAP  A 401 ( 3.3A)
NAP  A 401 ( 3.2A)
None
0.34A100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3VM4_A_IZPA1_1
(FATTY ACID
ALPHA-HYDROXYLASE)		1ex0 COAGULATION FACTOR
XIII A CHAIN
(Homo
sapiens)		4 / 5LEU A 385
ARG A 382
PRO A 411
ALA A 412
None
1.41A21.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3VM4_A_IZPA1_1
(FATTY ACID
ALPHA-HYDROXYLASE)		1tf0 SERUM ALBUMIN
(Homo
sapiens)		4 / 5LEU A 387
ARG A 485
PRO A 486
ALA A 490
None
1.43A20.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3VM4_A_IZPA1_1
(FATTY ACID
ALPHA-HYDROXYLASE)		1xcr HYPOTHETICAL PROTEIN
PTD012
(Homo
sapiens)		4 / 5LEU A 262
PHE A 260
ARG A 302
ALA A   4
None
1.47A19.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3VM4_A_IZPA1_1
(FATTY ACID
ALPHA-HYDROXYLASE)		1yxm PEROXISOMAL TRANS
2-ENOYL COA
REDUCTASE
(Homo
sapiens)		4 / 5LEU A  11
PHE A 245
PRO A 249
ALA A 251
None
1.24A20.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3VM4_A_IZPA1_1
(FATTY ACID
ALPHA-HYDROXYLASE)		2d9b GENERAL
TRANSCRIPTION FACTOR
II-I
(Homo
sapiens)		4 / 5LEU A  95
PHE A  94
PRO A  93
ALA A  53
None
1.18A12.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3VM4_A_IZPA1_1
(FATTY ACID
ALPHA-HYDROXYLASE)		2e3l TRANSCRIPTION FACTOR
GTF2IRD2 BETA
(Homo
sapiens)		4 / 5LEU A  85
PHE A  84
PRO A  83
ALA A  43
None
1.35A13.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3VM4_A_IZPA1_1
(FATTY ACID
ALPHA-HYDROXYLASE)		2lnl C-X-C CHEMOKINE
RECEPTOR TYPE 1
(Homo
sapiens)		4 / 5LEU A 202
PHE A 171
ARG A 175
PRO A 170
None
0.96A21.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3VM4_A_IZPA1_1
(FATTY ACID
ALPHA-HYDROXYLASE)		2oby PUTATIVE QUINONE
OXIDOREDUCTASE
(Homo
sapiens)		4 / 5LEU A  63
ARG A 267
PRO A  53
ALA A  57
None
1.31A21.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3VM4_A_IZPA1_1
(FATTY ACID
ALPHA-HYDROXYLASE)		3hfh TRANSCRIPTION
ELONGATION REGULATOR
1
(Homo
sapiens)		4 / 5LEU A 802
ARG A 826
PRO A 825
ALA A 829
None
None
MLY  A 828 ( 4.4A)
MLY  A 828 ( 3.7A)
1.49A17.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3VM4_A_IZPA1_1
(FATTY ACID
ALPHA-HYDROXYLASE)		3ifq E-CADHERIN
PLAKOGLOBIN
(Homo
sapiens;
Mus
musculus)		4 / 5LEU C 677
ARG C 630
PRO A 496
ALA A 500
None
1.11A13.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3VM4_A_IZPA1_1
(FATTY ACID
ALPHA-HYDROXYLASE)		4hj2 GLUTATHIONE
S-TRANSFERASE A1
(Homo
sapiens)		4 / 5LEU A 181
PHE A 136
PRO A 134
ALA A 135
None
1.36A19.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3VM4_A_IZPA1_1
(FATTY ACID
ALPHA-HYDROXYLASE)		5d4k POLYMERIC
IMMUNOGLOBULIN
RECEPTOR
(Homo
sapiens)		4 / 5PHE A 275
ARG A 271
PRO A 273
ALA A 274
None
1.37A21.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3VM4_A_IZPA1_1
(FATTY ACID
ALPHA-HYDROXYLASE)		5fwj HISTONE DEMETHYLASE
JARID1C
(Homo
sapiens)		4 / 5PHE A 597
ARG A  35
PRO A  36
ALA A  38
None
1.11A22.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3VM4_A_IZPA1_1
(FATTY ACID
ALPHA-HYDROXYLASE)		5i2c GATS-LIKE PROTEIN 3
(Homo
sapiens)		4 / 5LEU A  33
PHE A  32
PRO A 195
ALA A 198
None
0.73A20.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3VM4_A_IZPA1_1
(FATTY ACID
ALPHA-HYDROXYLASE)		5wu3 SPECKLE TARGETED
PIP5K1A-REGULATED
POLY(A) POLYMERASE
(Homo
sapiens)		4 / 5LEU A 862
PHE A 865
PRO A 867
ALA A 869
None
1.33A20.85
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4JTR_B_IZPB401_1
(ALDO-KETO REDUCTASE
FAMILY 1 MEMBER C2)		2fvl ALDO-KETO REDUCTASE
FAMILY 1, MEMBER C4
(Homo
sapiens)		4 / 6TYR A  24
TYR A  55
TRP A  86
HIS A 117
None
NAP  A1001 (-4.7A)
None
NAP  A1001 (-4.4A)
0.18A81.73
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4JTR_B_IZPB401_1
(ALDO-KETO REDUCTASE
FAMILY 1 MEMBER C2)		2ipj ALDO-KETO REDUCTASE
FAMILY 1 MEMBER C2
(Homo
sapiens)		5 / 6VAL A  54
TYR A  55
TRP A  86
HIS A 117
TRP A 227
FFA  A 325 (-4.8A)
FFA  A 325 ( 4.3A)
None
FFA  A 325 ( 3.8A)
FFA  A 325 (-3.8A)
0.18A99.69
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4JTR_B_IZPB401_1
(ALDO-KETO REDUCTASE
FAMILY 1 MEMBER C2)		2is7 ALDOSE REDUCTASE
(Homo
sapiens)		4 / 6VAL A  47
TYR A  48
TRP A  79
HIS A 110
2CL  A 317 (-4.2A)
2CL  A 317 ( 4.5A)
None
2CL  A 317 ( 3.8A)
0.22A49.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4JTR_B_IZPB401_1
(ALDO-KETO REDUCTASE
FAMILY 1 MEMBER C2)		2p2c CASPASE-2
(Homo
sapiens)		4 / 6TYR P  79
TYR B 273
HIS B 280
TRP B 238
None
1.30A21.62
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4JTR_B_IZPB401_1
(ALDO-KETO REDUCTASE
FAMILY 1 MEMBER C2)		5liy ALDO-KETO REDUCTASE
FAMILY 1 MEMBER B10
(Homo
sapiens)		4 / 6VAL X  48
TYR X  49
TRP X  80
HIS X 111
DQP  X 402 ( 4.5A)
DQP  X 402 ( 4.0A)
None
DQP  X 402 ( 4.1A)
0.27A48.77
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4JTR_B_IZPB401_1
(ALDO-KETO REDUCTASE
FAMILY 1 MEMBER C2)		6f2u ALDO-KETO REDUCTASE
FAMILY 1 MEMBER C3
(Homo
sapiens)		4 / 6TYR A  24
TYR A  55
TRP A  86
HIS A 117
CJ2  A 402 (-4.2A)
CJ2  A 402 ( 4.1A)
None
CJ2  A 402 ( 3.8A)
0.27A92.50