POTENTIAL TARGETS FROM HUMAN (RESULTS FROM SUB-STRUCTURAL SIMILARITY SEARCHES)
1) User may click on the DrReposER ID (the second column) to get information on the binding sites and drug molecule.
2) Click View (the second last column) to view matched residues and superposition in the NGL viewer (upper right part).
3) User may also click on the Dock (the last column) to get script for molecular docking in UCSF Chimera through AutoDock Vina.

DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XN3_A_ID8A1356_1
(THYROXINE-BINDING
GLOBULIN)		1a9n U2A'
(Homo
sapiens)		4 / 8LEU A  83
LEU A  66
LYS A  67
LEU A  93
None
1.15A18.95
13.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XN3_A_ID8A1356_1
(THYROXINE-BINDING
GLOBULIN)		1cnt CILIARY NEUROTROPHIC
FACTOR
(Homo
sapiens)		4 / 8LEU 1  73
LEU 1  16
LEU 1 176
ARG 1  13
None
None
None
SO4  1 190 (-3.7A)
1.02A18.99
15.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XN3_A_ID8A1356_1
(THYROXINE-BINDING
GLOBULIN)		1deb ADENOMATOUS
POLYPOSIS COLI
PROTEIN
(Homo
sapiens)		4 / 8LEU A  16
LYS A  17
ASN A  20
LEU A  23
None
0.42A13.50
19.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XN3_A_ID8A1356_1
(THYROXINE-BINDING
GLOBULIN)		1gk4 VIMENTIN
(Homo
sapiens)		4 / 8LEU A 333
LYS A 334
ASN A 337
LEU A 340
None
0.55A14.37
20.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XN3_A_ID8A1356_1
(THYROXINE-BINDING
GLOBULIN)		1ilk INTERLEUKIN-10
(Homo
sapiens)		4 / 8LEU A  65
LEU A  98
LYS A  99
LEU A 105
None
1.01A18.82
14.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XN3_A_ID8A1356_1
(THYROXINE-BINDING
GLOBULIN)		1ugk SYNAPTOTAGMIN IV
(Homo
sapiens)		4 / 8LEU A  15
LEU A  11
LEU A 126
ARG A 129
None
1.17A17.48
15.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XN3_A_ID8A1356_1
(THYROXINE-BINDING
GLOBULIN)		1uii GEMININ
(Homo
sapiens)		4 / 8LEU A 134
LYS A 135
ASN A 138
LEU A 141
None
0.52A13.02
21.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XN3_A_ID8A1356_1
(THYROXINE-BINDING
GLOBULIN)		2ilr FANCONI ANEMIA GROUP
E PROTEIN
(Homo
sapiens)		4 / 8GLN A 330
LEU A 326
LYS A 282
LEU A 288
None
1.18A23.58
10.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XN3_A_ID8A1356_1
(THYROXINE-BINDING
GLOBULIN)		2lkz RNA-BINDING PROTEIN
5
(Homo
sapiens)		4 / 8GLN A  74
LEU A  14
LEU A  70
ARG A  15
None
1.19A13.13
21.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XN3_A_ID8A1356_1
(THYROXINE-BINDING
GLOBULIN)		2lp0 HOMEOBOX PROTEIN
HOX-C9
(Homo
sapiens)		4 / 8GLN A  60
LEU A  56
LYS A  26
LEU A  32
None
1.10A11.18
24.44
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2XN3_A_ID8A1356_1
(THYROXINE-BINDING
GLOBULIN)		2xn6 THYROXINE-BINDING
GLOBULIN
(Homo
sapiens)		6 / 8GLN A 238
LEU A 246
LEU A 269
LYS A 270
ASN A 273
LEU A 276
T44  A1370 (-3.3A)
T44  A1370 (-4.6A)
T44  A1370 (-4.0A)
T44  A1370 (-4.8A)
T44  A1370 ( 3.3A)
None
0.18A99.42
7.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XN3_A_ID8A1356_1
(THYROXINE-BINDING
GLOBULIN)		3a6p EXPORTIN-5
(Homo
sapiens)		4 / 8GLN A 871
LEU A 770
LYS A 771
LEU A 777
None
0.90A15.11
3.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XN3_A_ID8A1356_1
(THYROXINE-BINDING
GLOBULIN)		3bxw CHITINASE
DOMAIN-CONTAINING
PROTEIN 1
(Homo
sapiens)		4 / 8GLN B 342
LEU B 277
LEU B 370
ARG B 349
None
0.95A21.07
6.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XN3_A_ID8A1356_1
(THYROXINE-BINDING
GLOBULIN)		3cqc NUCLEAR PORE COMPLEX
PROTEIN NUP107
NUCLEAR PORE COMPLEX
PROTEIN NUP133
(Homo
sapiens)		4 / 8LEU B 953
LEU A 904
LEU A 919
ARG A 905
None
0.95A21.33
15.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XN3_A_ID8A1356_1
(THYROXINE-BINDING
GLOBULIN)		3sag EXOSOME COMPONENT 10
(Homo
sapiens)		4 / 8LEU A 356
LEU A 297
ASN A 301
LEU A 304
LEU  A 356 ( 0.6A)
LEU  A 297 ( 0.6A)
ASN  A 301 ( 0.6A)
LEU  A 304 ( 0.6A)
1.10A21.97
9.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XN3_A_ID8A1356_1
(THYROXINE-BINDING
GLOBULIN)		3x05 PHOSPHATIDYLINOSITOL
5-PHOSPHATE 4-KINASE
TYPE-2 BETA
(Homo
sapiens)		4 / 8LEU A 179
LEU A 261
LYS A 258
ASN A 259
None
0.95A21.38
11.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XN3_A_ID8A1356_1
(THYROXINE-BINDING
GLOBULIN)		4ckg ARF-GAP WITH
COILED-COIL, ANK
REPEAT AND PH
DOMAIN-CONTAINING
PROTEIN 1
(Homo
sapiens)		4 / 8GLN A 102
LEU A  39
LYS A  40
LEU A  46
None
0.72A20.60
10.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XN3_A_ID8A1356_1
(THYROXINE-BINDING
GLOBULIN)		4l9u RAS GUANYL-RELEASING
PROTEIN 1
(Homo
sapiens)		4 / 8LEU A 758
LYS A 759
ASN A 762
LEU A 765
None
0.62A13.16
26.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XN3_A_ID8A1356_1
(THYROXINE-BINDING
GLOBULIN)		4uyg BROMODOMAIN-CONTAINI
NG PROTEIN 2
(Homo
sapiens)		4 / 8LEU A 350
LYS A 351
ASN A 354
LEU A 357
None
1.12A18.93
16.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XN3_A_ID8A1356_1
(THYROXINE-BINDING
GLOBULIN)		5f0p SORTING NEXIN-3
(Homo
sapiens)		4 / 8LEU C 145
LYS C 128
ASN C 127
LEU C  29
None
0.96A19.93
14.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XN3_A_ID8A1356_1
(THYROXINE-BINDING
GLOBULIN)		5h7s E3 UBIQUITIN-PROTEIN
LIGASE LNX
(Homo
sapiens)		4 / 8LEU D  39
LEU D  91
LYS D  90
ASN D  89
None
1.10A18.15
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XN3_A_ID8A1356_1
(THYROXINE-BINDING
GLOBULIN)		5jtv UBIQUITIN
CARBOXYL-TERMINAL
HYDROLASE 7
(Homo
sapiens)		4 / 8LEU A 528
LYS A 476
ASN A 470
LEU A 469
None
1.16A19.97
10.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XN3_A_ID8A1356_1
(THYROXINE-BINDING
GLOBULIN)		5xnp LEUCINE-RICH REPEAT
AND FIBRONECTIN
TYPE-III
DOMAIN-CONTAINING
PROTEIN 5
(Homo
sapiens)		4 / 8LEU A  77
LEU A  58
LEU A 104
ARG A  57
None
0.86A13.74
23.44
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3R43_A_ID8A332_1
(ALDO-KETO REDUCTASE
FAMILY 1 MEMBER C3)		2fvl ALDO-KETO REDUCTASE
FAMILY 1, MEMBER C4
(Homo
sapiens)		7 / 12TYR A  24
LEU A  54
TYR A  55
TRP A  86
HIS A 117
MET A 120
ASN A 167
None
None
NAP  A1001 (-4.7A)
None
NAP  A1001 (-4.4A)
None
NAP  A1001 (-3.1A)
0.53A84.21
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3R43_A_ID8A332_1
(ALDO-KETO REDUCTASE
FAMILY 1 MEMBER C3)		2fvl ALDO-KETO REDUCTASE
FAMILY 1, MEMBER C4
(Homo
sapiens)		5 / 12TYR A  24
LEU A  54
TYR A  55
TRP A  86
PHE A 310
None
None
NAP  A1001 (-4.7A)
None
None
0.90A84.21
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3R43_A_ID8A332_1
(ALDO-KETO REDUCTASE
FAMILY 1 MEMBER C3)		2ipj ALDO-KETO REDUCTASE
FAMILY 1 MEMBER C2
(Homo
sapiens)		5 / 12TYR A  55
TRP A  86
HIS A 117
ASN A 167
TYR A 216
FFA  A 325 ( 4.3A)
None
FFA  A 325 ( 3.8A)
NAP  A   1 (-3.1A)
NAP  A   1 (-3.2A)
0.12A86.60
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3R43_A_ID8A332_1
(ALDO-KETO REDUCTASE
FAMILY 1 MEMBER C3)		2is7 ALDOSE REDUCTASE
(Homo
sapiens)		5 / 12TYR A  48
TRP A  79
HIS A 110
ASN A 160
TYR A 209
2CL  A 317 ( 4.5A)
None
2CL  A 317 ( 3.8A)
NAP  A 316 (-3.4A)
NAP  A 316 (-3.2A)
0.29A48.15
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3R43_A_ID8A332_1
(ALDO-KETO REDUCTASE
FAMILY 1 MEMBER C3)		3cav 3-OXO-5-BETA-STEROID
4-DEHYDROGENASE
(Homo
sapiens)		6 / 12TYR A  26
TYR A  58
TRP A  89
MET A 123
ASN A 170
TYR A 219
CI2  A 328 ( 4.0A)
CI2  A 328 ( 4.5A)
None
None
NAP  A 327 (-3.6A)
NAP  A 327 (-3.4A)
0.56A55.52
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3R43_A_ID8A332_1
(ALDO-KETO REDUCTASE
FAMILY 1 MEMBER C3)		5liy ALDO-KETO REDUCTASE
FAMILY 1 MEMBER B10
(Homo
sapiens)		5 / 12TYR X  49
TRP X  80
HIS X 111
ASN X 161
TYR X 210
DQP  X 402 ( 4.0A)
None
DQP  X 402 ( 4.1A)
NAP  X 401 (-3.2A)
NAP  X 401 ( 3.1A)
0.28A46.75
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3R43_A_ID8A332_1
(ALDO-KETO REDUCTASE
FAMILY 1 MEMBER C3)		6f2u ALDO-KETO REDUCTASE
FAMILY 1 MEMBER C3
(Homo
sapiens)		7 / 12LEU A  54
TYR A  55
HIS A 117
SER A 118
ASN A 167
TRP A 227
PHE A 306
None
CJ2  A 402 ( 4.1A)
CJ2  A 402 ( 3.8A)
CJ2  A 402 ( 3.7A)
NAP  A 401 ( 3.3A)
CJ2  A 402 ( 4.8A)
CJ2  A 402 (-3.8A)
1.07A100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3R43_A_ID8A332_1
(ALDO-KETO REDUCTASE
FAMILY 1 MEMBER C3)		6f2u ALDO-KETO REDUCTASE
FAMILY 1 MEMBER C3
(Homo
sapiens)		5 / 12TYR A  24
LEU A  54
TYR A  55
HIS A 117
SER A  87
CJ2  A 402 (-4.2A)
None
CJ2  A 402 ( 4.1A)
CJ2  A 402 ( 3.8A)
None
1.43A100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3R43_A_ID8A332_1
(ALDO-KETO REDUCTASE
FAMILY 1 MEMBER C3)		6f2u ALDO-KETO REDUCTASE
FAMILY 1 MEMBER C3
(Homo
sapiens)		9 / 12TYR A  24
LEU A  54
TYR A  55
TRP A  86
HIS A 117
SER A 118
ASN A 167
TYR A 216
TRP A 227
CJ2  A 402 (-4.2A)
None
CJ2  A 402 ( 4.1A)
None
CJ2  A 402 ( 3.8A)
CJ2  A 402 ( 3.7A)
NAP  A 401 ( 3.3A)
NAP  A 401 ( 3.2A)
CJ2  A 402 ( 4.8A)
0.55A100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3R43_A_ID8A332_1
(ALDO-KETO REDUCTASE
FAMILY 1 MEMBER C3)		6f2u ALDO-KETO REDUCTASE
FAMILY 1 MEMBER C3
(Homo
sapiens)		9 / 12TYR A  24
LEU A  54
TYR A  55
TRP A  86
HIS A 117
SER A 118
MET A 120
ASN A 167
TYR A 216
CJ2  A 402 (-4.2A)
None
CJ2  A 402 ( 4.1A)
None
CJ2  A 402 ( 3.8A)
CJ2  A 402 ( 3.7A)
CJ2  A 402 ( 4.7A)
NAP  A 401 ( 3.3A)
NAP  A 401 ( 3.2A)
0.28A100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4G2Z_A_ID8A711_1
(LACTOTRANSFERRIN)		1n76 LACTOFERRIN
(Homo
sapiens)		3 / 3PRO A 251
TYR A 319
GLY A 321
None
0.47A68.89
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4G2Z_A_ID8A711_1
(LACTOTRANSFERRIN)		1n76 LACTOFERRIN
(Homo
sapiens)		3 / 3PRO A 595
TYR A 662
GLY A 664
None
0.38A68.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4G2Z_A_ID8A711_1
(LACTOTRANSFERRIN)		1p49 STERYL-SULFATASE
(Homo
sapiens)		3 / 3PRO A 379
TYR A  45
GLY A  40
None
None
NAG  A 603 (-4.5A)
0.67A19.22
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4G2Z_A_ID8A711_1
(LACTOTRANSFERRIN)		1ryo SEROTRANSFERRIN
(Homo
sapiens)		3 / 3PRO A 247
TYR A 314
GLY A 316
None
0.49A42.02
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4G2Z_A_ID8A711_1
(LACTOTRANSFERRIN)		1suv SEROTRANSFERRIN,
C-LOBE
(Homo
sapiens)		3 / 3PRO E 580
TYR E 647
GLY E 649
None
0.38A58.19
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4G2Z_A_ID8A711_1
(LACTOTRANSFERRIN)		1vfd LACTOFERRIN
(Homo
sapiens)		3 / 3PRO A 251
TYR A 319
GLY A 321
None
0.39A41.14
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4G2Z_A_ID8A711_1
(LACTOTRANSFERRIN)		2hau SEROTRANSFERRIN
(Homo
sapiens)		3 / 3PRO A 583
TYR A 650
GLY A 652
None
0.51A31.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4G2Z_A_ID8A711_1
(LACTOTRANSFERRIN)		3lqa HEAVY CHAIN OF ANTI
HIV FAB FROM HUMAN
21C ANTIBODY
(Homo
sapiens)		3 / 3PRO H 111
TYR H 102
GLY H 100
None
0.75A24.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4G2Z_A_ID8A711_1
(LACTOTRANSFERRIN)		3q2r GLIOMA
PATHOGENESIS-RELATED
PROTEIN 1
(Homo
sapiens)		3 / 3PRO A  50
TYR A 186
GLY A 189
None
0.71A20.65
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4G2Z_A_ID8A711_1
(LACTOTRANSFERRIN)		3skp SEROTRANSFERRIN
(Homo
sapiens)		3 / 3PRO A 583
TYR A 650
GLY A 652
None
None
SO4  A 683 (-3.4A)
0.44A59.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4G2Z_A_ID8A711_1
(LACTOTRANSFERRIN)		4bc5 XYLULOSE KINASE
(Homo
sapiens)		3 / 3PRO A 248
TYR A 213
GLY A 216
None
0.59A19.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4G2Z_A_ID8A711_1
(LACTOTRANSFERRIN)		4byf UNCONVENTIONAL
MYOSIN-IC
(Homo
sapiens)		3 / 3PRO A 593
TYR A  55
GLY A 600
None
AOV  A1001 ( 4.5A)
None
0.66A19.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4G2Z_A_ID8A711_1
(LACTOTRANSFERRIN)		4db1 MYOSIN-7
(Homo
sapiens)		3 / 3PRO A 675
TYR A 128
GLY A 682
None
ANP  A 801 ( 4.6A)
None
0.72A18.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4G2Z_A_ID8A711_1
(LACTOTRANSFERRIN)		4p7h MYOSIN-7,GREEN
FLUORESCENT PROTEIN
(Aequorea
victoria;
Homo
sapiens)		3 / 3PRO A 675
TYR A 128
GLY A 682
None
0.58A15.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4G2Z_A_ID8A711_1
(LACTOTRANSFERRIN)		5bow INTERLEUKIN-1 FAMILY
MEMBER 10
(Homo
sapiens)		3 / 3PRO A 125
TYR A  14
GLY A  30
None
None
EDO  A 205 ( 3.8A)
0.71A19.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4G2Z_A_ID8A711_1
(LACTOTRANSFERRIN)		5cni METABOTROPIC
GLUTAMATE RECEPTOR 2
(Homo
sapiens)		3 / 3PRO A  39
TYR A 144
GLY A 142
 CL  A 602 ( 4.0A)
None
CL  A 602 ( 4.1A)
0.73A21.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4G2Z_A_ID8A711_1
(LACTOTRANSFERRIN)		5kzn METABOTROPIC
GLUTAMATE RECEPTOR 2
(Homo
sapiens)		3 / 3PRO A  39
TYR A 144
GLY A 142
None
0.71A20.75
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4JQA_A_ID8A401_1
(ALDO-KETO REDUCTASE
FAMILY 1 MEMBER C2)		2fvl ALDO-KETO REDUCTASE
FAMILY 1, MEMBER C4
(Homo
sapiens)		5 / 9TYR A  24
TYR A  55
TRP A  86
HIS A 117
TRP A 227
None
NAP  A1001 (-4.7A)
None
NAP  A1001 (-4.4A)
None
0.81A81.73
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4JQA_A_ID8A401_1
(ALDO-KETO REDUCTASE
FAMILY 1 MEMBER C2)		2ipj ALDO-KETO REDUCTASE
FAMILY 1 MEMBER C2
(Homo
sapiens)		5 / 9VAL A  54
TYR A  55
HIS A 117
TRP A 227
LEU A 306
FFA  A 325 (-4.8A)
FFA  A 325 ( 4.3A)
FFA  A 325 ( 3.8A)
FFA  A 325 (-3.8A)
FFA  A 325 (-4.8A)
1.41A99.69
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4JQA_A_ID8A401_1
(ALDO-KETO REDUCTASE
FAMILY 1 MEMBER C2)		2ipj ALDO-KETO REDUCTASE
FAMILY 1 MEMBER C2
(Homo
sapiens)		8 / 9VAL A  54
TYR A  55
TRP A  86
HIS A 117
VAL A 128
ILE A 129
TRP A 227
LEU A 308
FFA  A 325 (-4.8A)
FFA  A 325 ( 4.3A)
None
FFA  A 325 ( 3.8A)
None
None
FFA  A 325 (-3.8A)
FFA  A 325 (-4.5A)
0.36A99.69
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4JQA_B_ID8B401_1
(ALDO-KETO REDUCTASE
FAMILY 1 MEMBER C2)		2fvl ALDO-KETO REDUCTASE
FAMILY 1, MEMBER C4
(Homo
sapiens)		5 / 9TYR A  24
TYR A  55
TRP A  86
HIS A 117
TRP A 227
None
NAP  A1001 (-4.7A)
None
NAP  A1001 (-4.4A)
None
0.84A81.73
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4JQA_B_ID8B401_1
(ALDO-KETO REDUCTASE
FAMILY 1 MEMBER C2)		2ipj ALDO-KETO REDUCTASE
FAMILY 1 MEMBER C2
(Homo
sapiens)		5 / 9VAL A  54
TYR A  55
HIS A 117
TRP A 227
LEU A 306
FFA  A 325 (-4.8A)
FFA  A 325 ( 4.3A)
FFA  A 325 ( 3.8A)
FFA  A 325 (-3.8A)
FFA  A 325 (-4.8A)
1.46A99.69
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4JQA_B_ID8B401_1
(ALDO-KETO REDUCTASE
FAMILY 1 MEMBER C2)		2ipj ALDO-KETO REDUCTASE
FAMILY 1 MEMBER C2
(Homo
sapiens)		8 / 9VAL A  54
TYR A  55
TRP A  86
HIS A 117
VAL A 128
ILE A 129
TRP A 227
LEU A 308
FFA  A 325 (-4.8A)
FFA  A 325 ( 4.3A)
None
FFA  A 325 ( 3.8A)
None
None
FFA  A 325 (-3.8A)
FFA  A 325 (-4.5A)
0.40A99.69
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4JQA_B_ID8B401_1
(ALDO-KETO REDUCTASE
FAMILY 1 MEMBER C2)		2is7 ALDOSE REDUCTASE
(Homo
sapiens)		5 / 9VAL A  47
TYR A  48
TRP A  79
HIS A 110
LEU A 300
2CL  A 317 (-4.2A)
2CL  A 317 ( 4.5A)
None
2CL  A 317 ( 3.8A)
None
0.86A49.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IKR_A_ID8A601_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		1jy1 TYROSYL-DNA
PHOSPHODIESTERASE
(Homo
sapiens)		5 / 12VAL A 227
TYR A 537
ALA A 332
SER A 334
LEU A 335
None
0.98A21.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IKR_A_ID8A601_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		1orf GRANZYME A
(Homo
sapiens)		5 / 12LEU A 155
TYR A  29
GLY A  44
ALA A  43
SER A 197
None
1.16A18.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IKR_A_ID8A601_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		2cw6 HYDROXYMETHYLGLUTARY
L-COA LYASE,
MITOCHONDRIAL
(Homo
sapiens)		5 / 12LEU A 299
VAL A 260
GLY A 262
ALA A 261
SER A 316
None
1.03A21.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IKR_A_ID8A601_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		2gk9 PHOSPHATIDYLINOSITOL
-4-PHOSPHATE
5-KINASE, TYPE II,
GAMMA
(Homo
sapiens)		5 / 12LEU A 126
TYR A 189
GLY A  54
ALA A  56
SER A  58
None
1.12A22.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IKR_A_ID8A601_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		2jpd DNA EXCISION REPAIR
PROTEIN ERCC-1
(Homo
sapiens)		5 / 12VAL A 171
LEU A 141
SER A 142
ALA A 181
LEU A 182
None
1.00A13.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IKR_A_ID8A601_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		3i6u SERINE/THREONINE-PRO
TEIN KINASE CHK2
(Homo
sapiens)		5 / 12LEU A 421
SER A 422
TYR A 424
TRP A 485
LEU A 467
None
1.15A22.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IKR_A_ID8A601_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		3vzb SPHINGOSINE KINASE 1
(Homo
sapiens)		5 / 12LEU A 263
GLY A 269
ALA A 115
SER A 119
LEU A 116
None
None
SQS  A 401 ( 4.8A)
None
None
1.05A19.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IKR_A_ID8A601_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		4mwt LYSOSOMAL PROTECTIVE
PROTEIN
(Homo
sapiens)		5 / 12VAL A 121
GLY A 103
ALA A 102
SER A 100
LEU A  34
VAL  A 121 ( 0.6A)
GLY  A 103 ( 0.0A)
ALA  A 102 ( 0.0A)
SER  A 100 ( 0.0A)
LEU  A  34 ( 0.6A)
1.17A21.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IKR_A_ID8A601_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		5fii PHENYLALANINE-4-HYDR
OXYLASE
(Homo
sapiens)		5 / 12VAL A  51
LEU A  54
GLY A 103
ALA A 104
LEU A  41
None
1.17A12.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IKR_A_ID8A601_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		5y3r DNA-DEPENDENT
PROTEIN KINASE
CATALYTIC SUBUNIT
(Homo
sapiens)		5 / 12LEU C 316
SER C 314
ALA C 362
SER C 360
LEU C 359
None
0.99A8.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IKR_A_ID8A601_2
(PROSTAGLANDIN G/H
SYNTHASE 2)		1l1o REPLICATION PROTEIN
A 32 KDA SUBUNIT
REPLICATION PROTEIN
A 70 KDA DNA-BINDING
SUBUNIT
(Homo
sapiens)		3 / 3VAL C 607
LEU B 149
MET B 152
None
0.66A17.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IKR_A_ID8A601_2
(PROSTAGLANDIN G/H
SYNTHASE 2)		1wuu GALACTOKINASE
(Homo
sapiens)		3 / 3VAL A 133
LEU A 325
MET A 343
None
0.82A20.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IKR_A_ID8A601_2
(PROSTAGLANDIN G/H
SYNTHASE 2)		1z6t APOPTOTIC PROTEASE
ACTIVATING FACTOR 1
(Homo
sapiens)		3 / 3VAL A 124
LEU A 306
MET A 301
None
0.87A23.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IKR_A_ID8A601_2
(PROSTAGLANDIN G/H
SYNTHASE 2)		2dyl DUAL SPECIFICITY
MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE 7
(Homo
sapiens)		3 / 3VAL A 196
LEU A 136
MET A 153
None
0.62A19.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IKR_A_ID8A601_2
(PROSTAGLANDIN G/H
SYNTHASE 2)		3se4 INTERFERON OMEGA-1
(Homo
sapiens)		3 / 3VAL B  58
LEU B  20
MET B 151
None
0.88A15.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IKR_A_ID8A601_2
(PROSTAGLANDIN G/H
SYNTHASE 2)		4i8v CYTOCHROME P450 1A1
(Homo
sapiens)		3 / 3VAL A 488
LEU A 174
MET A 508
None
0.88A22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IKR_A_ID8A601_2
(PROSTAGLANDIN G/H
SYNTHASE 2)		4ylj DUAL SPECIFICITY
TYROSINE-PHOSPHORYLA
TION-REGULATED
KINASE 1A
(Homo
sapiens)		3 / 3VAL A 352
LEU A 333
MET A 370
None
0.88A20.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IKR_A_ID8A601_2
(PROSTAGLANDIN G/H
SYNTHASE 2)		5wve APOPTOTIC
PROTEASE-ACTIVATING
FACTOR 1
(Homo
sapiens)		3 / 3VAL A 124
LEU A 306
MET A 301
None
0.72A18.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IKR_B_ID8B602_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		1f59 IMPORTIN BETA-1
(Homo
sapiens)		5 / 12VAL A  43
LEU A  44
LEU A   3
TYR A 104
ALA A  56
None
1.11A20.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IKR_B_ID8B602_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		1jy1 TYROSYL-DNA
PHOSPHODIESTERASE
(Homo
sapiens)		5 / 12VAL A 227
TYR A 537
ALA A 332
SER A 334
LEU A 335
None
0.99A21.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IKR_B_ID8B602_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		1xcr HYPOTHETICAL PROTEIN
PTD012
(Homo
sapiens)		5 / 12ARG A 302
VAL A 254
LEU A 264
GLY A 259
LEU A 300
None
1.01A19.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IKR_B_ID8B602_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		2cw6 HYDROXYMETHYLGLUTARY
L-COA LYASE,
MITOCHONDRIAL
(Homo
sapiens)		5 / 12LEU A 299
VAL A 260
GLY A 262
ALA A 261
SER A 316
None
1.04A21.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IKR_B_ID8B602_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		2gk9 PHOSPHATIDYLINOSITOL
-4-PHOSPHATE
5-KINASE, TYPE II,
GAMMA
(Homo
sapiens)		5 / 12LEU A 126
TYR A 189
GLY A  54
ALA A  56
SER A  58
None
1.02A22.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IKR_B_ID8B602_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		3a6p EXPORTIN-5
(Homo
sapiens)		5 / 12VAL A 896
LEU A 899
LEU A 972
VAL A 912
LEU A 919
None
1.10A18.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IKR_B_ID8B602_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		4asi ACETYL-COA
CARBOXYLASE 1
(Homo
sapiens)		5 / 12LEU A1737
GLY A1842
ALA A1841
SER A1844
LEU A1868
None
1.09A20.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IKR_B_ID8B602_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		4p7h MYOSIN-7,GREEN
FLUORESCENT PROTEIN
(Aequorea
victoria;
Homo
sapiens)		5 / 12LEU A 614
TYR A 609
LEU A 390
GLY A 354
ALA A 355
None
1.04A20.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IKR_B_ID8B602_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		4pj6 LEUCYL-CYSTINYL
AMINOPEPTIDASE
(Homo
sapiens)		5 / 12VAL A1006
LEU A 524
VAL A 967
GLY A 969
ALA A 968
None
1.00A21.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IKR_B_ID8B602_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		5m32 PROTEASOME SUBUNIT
BETA TYPE-2
(Homo
sapiens)		5 / 12LEU J   4
TYR J 117
GLY J 135
ALA J 136
LEU J 140
None
1.00A16.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IKR_B_ID8B602_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		5nug CYTOPLASMIC DYNEIN 1
HEAVY CHAIN 1
(Homo
sapiens)		5 / 12VAL A4309
LEU A4312
TRP A4320
GLY A4152
ALA A4155
None
1.07A7.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IKR_B_ID8B602_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		5uqe GLUTAMINASE KIDNEY
ISOFORM,
MITOCHONDRIAL
(Homo
sapiens)		6 / 12VAL A 422
LEU A 284
VAL A 429
GLY A 367
ALA A 366
LEU A 362
None
1.40A21.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IKR_B_ID8B602_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		5wu3 SPECKLE TARGETED
PIP5K1A-REGULATED
POLY(A) POLYMERASE
(Homo
sapiens)		6 / 12LEU A 422
LEU A 437
VAL A 559
GLY A 561
ALA A 560
LEU A 507
None
1.30A20.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IKR_B_ID8B602_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		5wu6 SPECKLE TARGETED
PIP5K1A-REGULATED
POLY(A) POLYMERASE
(Homo
sapiens)		6 / 12LEU A 422
LEU A 437
VAL A 559
GLY A 561
ALA A 560
LEU A 507
None
1.30A21.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IKR_B_ID8B602_2
(PROSTAGLANDIN G/H
SYNTHASE 2)		1cjy PROTEIN (CYTOSOLIC
PHOSPHOLIPASE A2)
(Homo
sapiens)		3 / 3SER A 230
LEU A 386
MET A 390
None
0.78A21.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IKR_B_ID8B602_2
(PROSTAGLANDIN G/H
SYNTHASE 2)		1deu PROCATHEPSIN X
(Homo
sapiens)		3 / 3SER A 136
LEU A   1
MET A 142
None
0.87A17.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IKR_B_ID8B602_2
(PROSTAGLANDIN G/H
SYNTHASE 2)		1ikf IGG1-KAPPA R45-45-11
FAB (HEAVY CHAIN)
(Homo
sapiens)		3 / 3SER H  88
LEU H  81
MET H  83
None
0.88A17.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IKR_B_ID8B602_2
(PROSTAGLANDIN G/H
SYNTHASE 2)		3dzu RETINOIC ACID
RECEPTOR RXR-ALPHA
(Homo
sapiens)		3 / 3SER A 355
LEU A 367
MET A 362
None
0.80A21.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IKR_B_ID8B602_2
(PROSTAGLANDIN G/H
SYNTHASE 2)		3f70 LETHAL(3)MALIGNANT
BRAIN TUMOR-LIKE 2
PROTEIN
(Homo
sapiens)		3 / 3SER A 335
LEU A 442
MET A 548
None
0.86A19.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IKR_B_ID8B602_2
(PROSTAGLANDIN G/H
SYNTHASE 2)		3in5 DNA POLYMERASE KAPPA
(Homo
sapiens)		3 / 3SER A 423
LEU A 438
MET A 509
None
0.84A20.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IKR_B_ID8B602_2
(PROSTAGLANDIN G/H
SYNTHASE 2)		3j9f POLIOVIRUS RECEPTOR
(Homo
sapiens)		3 / 3SER 7 107
LEU 7 113
MET 7 110
NAG  7 401 ( 3.7A)
None
None
0.84A12.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IKR_B_ID8B602_2
(PROSTAGLANDIN G/H
SYNTHASE 2)		3smt HISTONE-LYSINE
N-METHYLTRANSFERASE
SETD3
(Homo
sapiens)		3 / 3SER A 345
LEU A 394
MET A 351
None
None
UNX  A 509 ( 4.4A)
0.88A20.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IKR_B_ID8B602_2
(PROSTAGLANDIN G/H
SYNTHASE 2)		4hf5 FAB 8F8 HEAVY CHAIN
(Homo
sapiens)		3 / 3SER H  21
LEU H  82
MET H  82
None
0.86A17.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IKR_B_ID8B602_2
(PROSTAGLANDIN G/H
SYNTHASE 2)		4js1 BETA-GALACTOSIDE
ALPHA-2,6-SIALYLTRAN
SFERASE 1
(Homo
sapiens)		3 / 3SER A 151
LEU A 209
MET A 331
None
0.72A20.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IKR_B_ID8B602_2
(PROSTAGLANDIN G/H
SYNTHASE 2)		4nxr T-LYMPHOMA INVASION
AND
METASTASIS-INDUCING
PROTEIN 1
(Homo
sapiens)		3 / 3SER A 919
LEU A 906
MET A 911
None
0.77A12.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IKR_B_ID8B602_2
(PROSTAGLANDIN G/H
SYNTHASE 2)		4uok FAB FRAGMENT HEAVY
CHAIN
(Homo
sapiens)		3 / 3SER A 317
LEU A 263
MET A 255
None
0.70A15.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IKR_B_ID8B602_2
(PROSTAGLANDIN G/H
SYNTHASE 2)		5f9w HEAVY CHAIN OF
CH235-LINEAGE
ANTIBODY CH235
(Homo
sapiens)		3 / 3SER B  21
LEU B  82
MET B  82
None
0.83A16.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IKR_B_ID8B602_2
(PROSTAGLANDIN G/H
SYNTHASE 2)		5nqa POLYPEPTIDE
N-ACETYLGALACTOSAMIN
YLTRANSFERASE 4
(Homo
sapiens)		3 / 3SER A 473
LEU A 502
MET A 515
None
0.86A10.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IKR_B_ID8B602_2
(PROSTAGLANDIN G/H
SYNTHASE 2)		5nv6 TRANSFORMING GROWTH
FACTOR-BETA-INDUCED
PROTEIN IG-H3
(Homo
sapiens)		3 / 3SER A 516
LEU A 531
MET A 506
None
0.81A22.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IKR_B_ID8B602_2
(PROSTAGLANDIN G/H
SYNTHASE 2)		6bq1 PHOSPHATIDYLINOSITOL
4-KINASE III ALPHA
(PI4KA)
(Homo
sapiens)		3 / 3SER A1622
LEU A1860
MET A2041
None
0.68A0.00