POTENTIAL TARGETS FROM HUMAN (RESULTS FROM SUB-STRUCTURAL SIMILARITY SEARCHES)
1) User may click on the DrReposER ID (the second column) to get information on the binding sites and drug molecule.
2) Click View (the second last column) to view matched residues and superposition in the NGL viewer (upper right part).
3) User may also click on the Dock (the last column) to get script for molecular docking in UCSF Chimera through AutoDock Vina.

DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XZ3_A_ICFA201_1
(FERRITIN LIGHT CHAIN)		1cnt CILIARY NEUROTROPHIC
FACTOR
(Homo
sapiens)		4 / 4LEU 1  34
SER 1  37
TYR 1  38
LEU 1 162
None
1.23A22.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XZ3_A_ICFA201_1
(FERRITIN LIGHT CHAIN)		1ldj CULLIN HOMOLOG 1
(Homo
sapiens)		4 / 4LEU A 559
SER A 562
TYR A 563
LEU A 555
None
0.82A14.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XZ3_A_ICFA201_1
(FERRITIN LIGHT CHAIN)		1u0n PLATELET
GLYCOPROTEIN IB
(Homo
sapiens)		4 / 4LEU D 131
SER D 108
TYR D 130
LEU D 129
None
1.29A22.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XZ3_A_ICFA201_1
(FERRITIN LIGHT CHAIN)		2o8e DNA MISMATCH REPAIR
PROTEIN MSH6
(Homo
sapiens)		4 / 4LEU B 473
SER B 470
TYR B 469
LEU B 447
None
1.20A11.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XZ3_A_ICFA201_1
(FERRITIN LIGHT CHAIN)		2wd9 ACYL-COENZYME A
SYNTHETASE ACSM2A,
MITOCHONDRIAL
(Homo
sapiens)		4 / 4LEU A 323
SER A 324
TYR A 326
LEU A 297
None
1.12A15.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XZ3_A_ICFA201_1
(FERRITIN LIGHT CHAIN)		3fcx S-FORMYLGLUTATHIONE
HYDROLASE
(Homo
sapiens)		4 / 4LEU A 207
SER A 210
TYR A 211
LEU A 160
None
1.10A21.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XZ3_A_ICFA201_1
(FERRITIN LIGHT CHAIN)		3fhc NUCLEAR PORE COMPLEX
PROTEIN NUP214
(Homo
sapiens)		4 / 4LEU A 317
SER A 308
TYR A 309
LEU A 315
None
1.09A18.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XZ3_A_ICFA201_1
(FERRITIN LIGHT CHAIN)		3nks PROTOPORPHYRINOGEN
OXIDASE
(Homo
sapiens)		4 / 4LEU A  15
SER A  18
TYR A  19
LEU A 240
None
1.32A18.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XZ3_A_ICFA201_1
(FERRITIN LIGHT CHAIN)		3omv RAF PROTO-ONCOGENE
SERINE/THREONINE-PRO
TEIN KINASE
(Homo
sapiens)		4 / 4LEU A 546
SER A 549
TYR A 548
LEU A 510
None
1.25A19.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XZ3_A_ICFA201_1
(FERRITIN LIGHT CHAIN)		4f52 CULLIN-1
(Homo
sapiens)		4 / 4LEU A 559
SER A 562
TYR A 563
LEU A 555
None
0.94A21.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XZ3_A_ICFA201_1
(FERRITIN LIGHT CHAIN)		4log MALTOSE ABC
TRANSPORTER
PERIPLASMIC PROTEIN
AND NR2E3 PROTEIN
CHIMERIC CONSTRUCT
(Escherichia
coli;
Homo
sapiens)		4 / 4LEU A 306
SER A 308
TYR A 309
LEU A 292
None
1.28A16.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XZ3_A_ICFA201_1
(FERRITIN LIGHT CHAIN)		4xaj MALTOSE-BINDING
PERIPLASMIC
PROTEIN,NUCLEAR
RECEPTOR SUBFAMILY 2
GROUP E MEMBER 1
(Escherichia
coli;
Homo
sapiens)		4 / 4LEU A 306
SER A 308
TYR A 309
LEU A 292
None
1.17A14.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XZ3_A_ICFA201_1
(FERRITIN LIGHT CHAIN)		5e3c DIPEPTIDYL PEPTIDASE
3
(Homo
sapiens)		4 / 4LEU A 516
SER A 519
TYR A 517
LEU A 618
None
1.25A14.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XZ3_A_ICFA201_1
(FERRITIN LIGHT CHAIN)		5fd2 SERINE/THREONINE-PRO
TEIN KINASE B-RAF
(Homo
sapiens)		4 / 4LEU A 654
SER A 657
TYR A 656
LEU A 618
None
1.01A19.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XZ3_A_ICFA201_1
(FERRITIN LIGHT CHAIN)		5l3x NEGATIVE ELONGATION
FACTOR C/D
(Homo
sapiens)		4 / 4LEU B 529
SER B 528
TYR B 532
LEU B 497
None
1.05A20.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XZ3_A_ICFA201_1
(FERRITIN LIGHT CHAIN)		5nj8 ARYL HYDROCARBON
RECEPTOR
(Homo
sapiens)		4 / 4LEU A  72
SER A  75
TYR A  76
LEU A  54
None
1.27A24.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XZ3_A_ICFA201_1
(FERRITIN LIGHT CHAIN)		5y7y ARYL HYDROCARBON
RECEPTOR REPRESSOR
(Homo
sapiens)		4 / 4LEU A  73
SER A  76
TYR A  77
LEU A  55
None
0.67A20.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XZ3_A_ICFA201_1
(FERRITIN LIGHT CHAIN)		5yz0 SERINE/THREONINE-PRO
TEIN KINASE ATR
(Homo
sapiens)		4 / 4LEU A2314
SER A2313
TYR A2322
LEU A2262
None
1.21A17.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XZ3_A_ICFA201_1
(FERRITIN LIGHT CHAIN)		6caj TRANSLATION
INITIATION FACTOR
EIF-2B SUBUNIT BETA
(Homo
sapiens)		4 / 4LEU C 339
SER C 341
TYR C 344
LEU C 274
None
1.19A20.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3F78_A_ICFA1_1
(INTEGRIN ALPHA-L)		1wer P120GAP
(Homo
sapiens)		5 / 9ILE A 821
LYS A 820
GLU A 854
LEU A 855
LYS A 858
None
1.14A20.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3F78_A_ICFA1_1
(INTEGRIN ALPHA-L)		2nn6 EXOSOME COMPLEX
EXONUCLEASE RRP43
EXOSOME COMPONENT 6
(Homo
sapiens)		5 / 9ILE C  59
GLU F 152
LEU F 151
LYS F  61
TYR F  54
None
1.23A20.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3F78_A_ICFA1_1
(INTEGRIN ALPHA-L)		2qp4 BILE SALT
SULFOTRANSFERASE
(Homo
sapiens)		5 / 9ILE A  53
ILE A 198
LEU A 182
GLU A 186
LEU A 187
None
1.14A20.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3F78_A_ICFA1_1
(INTEGRIN ALPHA-L)		2qp4 BILE SALT
SULFOTRANSFERASE
(Homo
sapiens)		5 / 9ILE A 198
LYS A 197
LEU A 182
GLU A 186
LEU A 187
None
1.00A20.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3F78_A_ICFA1_1
(INTEGRIN ALPHA-L)		2v55 RHO-ASSOCIATED
PROTEIN KINASE 1
(Homo
sapiens)		5 / 9ILE A  66
ILE A  63
LEU A  34
LEU A  31
TYR A 400
None
1.30A21.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3F78_A_ICFA1_1
(INTEGRIN ALPHA-L)		2v5e GDNF FAMILY RECEPTOR
ALPHA-1
GLIAL CELL
LINE-DERIVED
NEUROTROPHIC FACTOR
(Homo
sapiens;
Rattus
norvegicus)		5 / 9ILE A 229
TYR A 174
ILE A 293
LEU A 212
TYR B 120
None
1.42A20.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3F78_A_ICFA1_1
(INTEGRIN ALPHA-L)		3avs LYSINE-SPECIFIC
DEMETHYLASE 6A
(Homo
sapiens)		5 / 9ILE A1157
ILE A1159
GLU A1102
LEU A1103
LYS A1105
None
EDO  A1513 (-4.5A)
None
None
None
1.24A17.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3F78_A_ICFA1_1
(INTEGRIN ALPHA-L)		3bg9 PYRUVATE
CARBOXYLASE,
MITOCHONDRIAL
(Homo
sapiens)		5 / 9ILE A 913
ILE A 952
LEU A 680
LEU A 904
TYR A 894
None
1.15A13.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3F78_A_ICFA1_1
(INTEGRIN ALPHA-L)		4b18 IMPORTIN SUBUNIT
ALPHA-1
(Homo
sapiens)		5 / 9ILE A 472
ILE A 481
LEU A 499
GLU A 448
LEU A 451
None
1.30A17.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3F78_A_ICFA1_1
(INTEGRIN ALPHA-L)		4uad IMPORTIN SUBUNIT
ALPHA-7
(Homo
sapiens)		5 / 9ILE A 470
ILE A 479
LEU A 497
GLU A 446
LEU A 449
None
1.31A19.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3F78_A_ICFA1_1
(INTEGRIN ALPHA-L)		4uy4 SPINDLIN-4
(Homo
sapiens)		5 / 9ILE A  75
ILE A 210
LYS A 223
LEU A  73
TYR A  78
GOL  A1237 ( 4.0A)
GOL  A1237 (-4.0A)
None
None
None
1.28A20.09
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3F78_A_ICFA1_1
(INTEGRIN ALPHA-L)		5e6s INTEGRIN ALPHA-L
(Homo
sapiens)		5 / 9ILE A 235
TYR A 257
ILE A 259
LEU A 298
GLU A 301
None
0.87A76.69
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3F78_A_ICFA1_1
(INTEGRIN ALPHA-L)		5e6s INTEGRIN ALPHA-L
(Homo
sapiens)		5 / 9ILE A 235
TYR A 257
ILE A 259
LYS A 287
LEU A 298
None
0.38A76.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3F78_A_ICFA1_1
(INTEGRIN ALPHA-L)		5e9j MRNA CAP GUANINE-N7
METHYLTRANSFERASE,MR
NA CAP GUANINE-N7
METHYLTRANSFERASE
(Homo
sapiens)		5 / 9ILE A 280
TYR A 313
ILE A 315
LEU A 183
GLU A 186
None
1.26A23.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3F78_A_ICFA1_1
(INTEGRIN ALPHA-L)		5f0l VACUOLAR PROTEIN
SORTING-ASSOCIATED
PROTEIN 26A
(Homo
sapiens)		5 / 9ILE B 248
ILE B 195
LEU B 276
LEU B 274
TYR B 185
None
1.26A20.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3F78_A_ICFA1_1
(INTEGRIN ALPHA-L)		5fxv HISTONE DEMETHYLASE
UTY
(Homo
sapiens)		5 / 9ILE A1104
ILE A1106
GLU A1049
LEU A1050
LYS A1052
None
1.25A19.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3F78_A_ICFA1_1
(INTEGRIN ALPHA-L)		5xv7 SERINE-ARGININE (SR)
PROTEIN KINASE 1
(Homo
sapiens)		5 / 9ILE A 176
ILE A 177
GLU A 217
LYS A 215
TYR A 517
None
1.39A17.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3F78_A_ICFA1_1
(INTEGRIN ALPHA-L)		6g8r NUCLEAR BODY PROTEIN
SP140
(Homo
sapiens)		5 / 9ILE B 826
ILE B 804
LYS B 803
GLU B 797
TYR B 785
None
1.37A17.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3F78_B_ICFB2_1
(INTEGRIN ALPHA-L)		2qp4 BILE SALT
SULFOTRANSFERASE
(Homo
sapiens)		5 / 9ILE A  53
ILE A 198
LEU A 182
GLU A 186
LEU A 187
None
1.16A20.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3F78_B_ICFB2_1
(INTEGRIN ALPHA-L)		2qp4 BILE SALT
SULFOTRANSFERASE
(Homo
sapiens)		5 / 9ILE A 198
LYS A 197
LEU A 182
GLU A 186
LEU A 187
None
1.06A20.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3F78_B_ICFB2_1
(INTEGRIN ALPHA-L)		2v55 RHO-ASSOCIATED
PROTEIN KINASE 1
(Homo
sapiens)		5 / 9ILE A  66
ILE A  63
LEU A  34
LEU A  31
TYR A 400
None
1.33A21.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3F78_B_ICFB2_1
(INTEGRIN ALPHA-L)		2v5e GDNF FAMILY RECEPTOR
ALPHA-1
GLIAL CELL
LINE-DERIVED
NEUROTROPHIC FACTOR
(Homo
sapiens;
Rattus
norvegicus)		5 / 9ILE A 229
TYR A 174
ILE A 293
LEU A 212
TYR B 120
None
1.41A20.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3F78_B_ICFB2_1
(INTEGRIN ALPHA-L)		3avs LYSINE-SPECIFIC
DEMETHYLASE 6A
(Homo
sapiens)		5 / 9ILE A1157
ILE A1159
GLU A1102
LEU A1103
LYS A1105
None
EDO  A1513 (-4.5A)
None
None
None
1.31A17.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3F78_B_ICFB2_1
(INTEGRIN ALPHA-L)		3bg9 PYRUVATE
CARBOXYLASE,
MITOCHONDRIAL
(Homo
sapiens)		5 / 9ILE A 913
ILE A 952
LEU A 680
LEU A 904
TYR A 894
None
1.16A13.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3F78_B_ICFB2_1
(INTEGRIN ALPHA-L)		3fub GDNF FAMILY RECEPTOR
ALPHA-1
GLIAL CELL
LINE-DERIVED
NEUROTROPHIC FACTOR
(Homo
sapiens;
Rattus
norvegicus)		5 / 9ILE A 229
TYR A 174
ILE A 293
LEU A 212
TYR B 120
None
1.41A19.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3F78_B_ICFB2_1
(INTEGRIN ALPHA-L)		4b18 IMPORTIN SUBUNIT
ALPHA-1
(Homo
sapiens)		5 / 9ILE A 472
ILE A 481
LEU A 499
GLU A 448
LEU A 451
None
1.34A17.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3F78_B_ICFB2_1
(INTEGRIN ALPHA-L)		4uad IMPORTIN SUBUNIT
ALPHA-7
(Homo
sapiens)		5 / 9ILE A 470
ILE A 479
LEU A 497
GLU A 446
LEU A 449
None
1.35A19.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3F78_B_ICFB2_1
(INTEGRIN ALPHA-L)		4uy4 SPINDLIN-4
(Homo
sapiens)		5 / 9ILE A  75
ILE A 210
LYS A 223
LEU A  73
TYR A  78
GOL  A1237 ( 4.0A)
GOL  A1237 (-4.0A)
None
None
None
1.27A20.09
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3F78_B_ICFB2_1
(INTEGRIN ALPHA-L)		5e6s INTEGRIN ALPHA-L
(Homo
sapiens)		5 / 9ILE A 235
TYR A 257
ILE A 259
LYS A 287
LEU A 298
None
0.34A76.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3F78_B_ICFB2_1
(INTEGRIN ALPHA-L)		5f0l VACUOLAR PROTEIN
SORTING-ASSOCIATED
PROTEIN 26A
(Homo
sapiens)		5 / 9ILE B 248
ILE B 195
LEU B 276
LEU B 274
TYR B 185
None
1.24A20.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3F78_B_ICFB2_1
(INTEGRIN ALPHA-L)		5fxv HISTONE DEMETHYLASE
UTY
(Homo
sapiens)		5 / 9ILE A1104
ILE A1106
GLU A1049
LEU A1050
LYS A1052
None
1.33A19.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3F78_B_ICFB2_1
(INTEGRIN ALPHA-L)		6g8r NUCLEAR BODY PROTEIN
SP140
(Homo
sapiens)		5 / 9ILE B 826
ILE B 804
LYS B 803
GLU B 797
TYR B 785
None
1.37A17.39