POTENTIAL TARGETS FROM HUMAN (RESULTS FROM SUB-STRUCTURAL SIMILARITY SEARCHES)
1) User may click on the DrReposER ID (the second column) to get information on the binding sites and drug molecule.
2) Click View (the second last column) to view matched residues and superposition in the NGL viewer (upper right part).
3) User may also click on the Dock (the last column) to get script for molecular docking in UCSF Chimera through AutoDock Vina.

DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OC8_A_HU5A999_1
(HEPATITIS C VIRUS)		2yd3 RECEPTOR-TYPE
TYROSINE-PROTEIN
PHOSPHATASE S
(Homo
sapiens)		5 / 12ARG A  92
LEU A 122
PHE A  52
ALA A  50
VAL A  49
None
1.00A20.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OC8_A_HU5A999_1
(HEPATITIS C VIRUS)		2yd7 PTPRD PROTEIN
(Homo
sapiens)		5 / 12ARG A  83
LEU A 113
PHE A  43
ALA A  41
VAL A  40
None
0.92A25.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OC8_A_HU5A999_1
(HEPATITIS C VIRUS)		3gvp ADENOSYLHOMOCYSTEINA
SE 3
(Homo
sapiens)		5 / 12ILE A 293
LEU A 314
GLY A 311
ALA A 257
ALA A 256
None
1.00A18.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OC8_A_HU5A999_1
(HEPATITIS C VIRUS)		4oe5 DELTA-1-PYRROLINE-5-
CARBOXYLATE
DEHYDROGENASE,
MITOCHONDRIAL
(Homo
sapiens)		6 / 12ILE A 248
LEU A 249
GLY A 217
ARG A 171
ALA A 132
ALA A 131
None
1.28A16.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OC8_A_HU5A999_1
(HEPATITIS C VIRUS)		4oe5 DELTA-1-PYRROLINE-5-
CARBOXYLATE
DEHYDROGENASE,
MITOCHONDRIAL
(Homo
sapiens)		6 / 12ILE A 248
LEU A 249
PHE A 170
ARG A 171
ALA A 132
ALA A 131
None
1.45A16.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OC8_A_HU5A999_1
(HEPATITIS C VIRUS)		5vad BIFUNCTIONAL
GLUTAMATE/PROLINE--T
RNA LIGASE
(Homo
sapiens)		5 / 12ILE A1404
LEU A1401
PHE A1379
ALA A1381
VAL A1382
None
0.98A19.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OC8_A_HU5A999_1
(HEPATITIS C VIRUS)		5xnp RECEPTOR-TYPE
TYROSINE-PROTEIN
PHOSPHATASE DELTA
(Homo
sapiens)		5 / 12ARG D  83
LEU D 113
PHE D  43
ALA D  41
VAL D  40
None
0.98A21.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OC8_A_HU5A999_1
(HEPATITIS C VIRUS)		5xtb NADH-UBIQUINONE
OXIDOREDUCTASE 75
KDA SUBUNIT,
MITOCHONDRIAL
(Homo
sapiens)		5 / 12GLN M 522
ILE M 537
ALA M 340
ALA M 339
VAL M 338
None
1.00A16.35