POTENTIAL TARGETS FROM HUMAN (RESULTS FROM SUB-STRUCTURAL SIMILARITY SEARCHES)
1) User may click on the DrReposER ID (the second column) to get information on the binding sites and drug molecule.
2) Click View (the second last column) to view matched residues and superposition in the NGL viewer (upper right part).
3) User may also click on the Dock (the last column) to get script for molecular docking in UCSF Chimera through AutoDock Vina.

DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Seq.
Identity (%)		 View Dock
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1AVN_A_HSMA264_1
(CARBONIC ANHYDRASE
II)		4qk3 CARBONIC ANHYDRASE 2
(Homo
sapiens)		4 / 4ASN A  62
HIS A  64
ASN A  67
GLN A  92
None
0.29A95.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1IKE_A_HSMA190_1
(NITROPHORIN 4)		1dr9 T LYMPHOCYTE
ACTIVATION ANTIGEN
(Homo
sapiens)		3 / 3ASP A  76
LEU A  70
LEU A  72
None
0.59A19.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1IKE_A_HSMA190_1
(NITROPHORIN 4)		2l4c ENDOPLASMIC
RETICULUM RESIDENT
PROTEIN 27
(Homo
sapiens)		3 / 3ASP A  98
LEU A  92
LEU A  94
None
0.70A21.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1IKE_A_HSMA190_1
(NITROPHORIN 4)		2mtg LA-RELATED PROTEIN 6
(Homo
sapiens)		3 / 3ASP A 190
LEU A 197
LEU A 191
None
0.69A24.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1IKE_A_HSMA190_1
(NITROPHORIN 4)		2p8u HYDROXYMETHYLGLUTARY
L-COA SYNTHASE,
CYTOPLASMIC
(Homo
sapiens)		3 / 3ASP A 282
LEU A 275
LEU A 279
None
0.68A19.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1IKE_A_HSMA190_1
(NITROPHORIN 4)		3rc0 N-LYSINE
METHYLTRANSFERASE
SETD6
(Homo
sapiens)		3 / 3ASP A 434
LEU A 167
LEU A 455
None
0.78A17.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1IKE_A_HSMA190_1
(NITROPHORIN 4)		3vn9 DUAL SPECIFICITY
MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE 6
(Homo
sapiens)		3 / 3ASP A 239
LEU A 169
LEU A 166
None
0.69A20.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1IKE_A_HSMA190_1
(NITROPHORIN 4)		4igm 2-AMINO-3-CARBOXYMUC
ONATE-6-SEMIALDEHYDE
DECARBOXYLASE
(Homo
sapiens)		3 / 3ASP A 279
LEU A 272
LEU A 276
None
0.53A20.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1IKE_A_HSMA190_1
(NITROPHORIN 4)		4j0w U3 SMALL NUCLEOLAR
RNA-INTERACTING
PROTEIN 2
(Homo
sapiens)		3 / 3ASP A 290
LEU A 386
LEU A 332
None
0.66A18.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1IKE_A_HSMA190_1
(NITROPHORIN 4)		4jvs RAS-RELATED PROTEIN
RAB-1A
(Homo
sapiens)		3 / 3ASP B  66
LEU B  29
LEU B  28
 MG  B 402 ( 3.8A)
None
None
0.72A22.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1IKE_A_HSMA190_1
(NITROPHORIN 4)		4mhl INTERLEUKIN-11
(Homo
sapiens)		3 / 3ASP A  52
LEU A  45
LEU A  49
SO4  A 201 (-4.3A)
None
None
0.50A19.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1IKE_A_HSMA190_1
(NITROPHORIN 4)		5mv9 UNCONVENTIONAL
MYOSIN-VIIA
(Homo
sapiens)		3 / 3ASP A1811
LEU A1851
LEU A1850
None
0.68A17.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1IKE_A_HSMA190_1
(NITROPHORIN 4)		5nuv AUTOPHAGY-RELATED
PROTEIN 16-1
(Homo
sapiens)		3 / 3ASP A 454
LEU A 496
LEU A 494
None
0.75A20.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1IKE_A_HSMA190_1
(NITROPHORIN 4)		5t0h 26S PROTEASOME
NON-ATPASE
REGULATORY SUBUNIT 2
(Homo
sapiens)		3 / 3ASP f 262
LEU f 255
LEU f 259
None
0.69A13.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1IKE_A_HSMA190_1
(NITROPHORIN 4)		5xbf UNCONVENTIONAL
MYOSIN-VIIB
(Homo
sapiens)		3 / 3ASP A1708
LEU A1748
LEU A1747
None
0.66A17.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1IKE_A_HSMA190_1
(NITROPHORIN 4)		5xfo PHD FINGER PROTEIN 1
(Homo
sapiens)		3 / 3ASP A 253
LEU A 247
LEU A 249
None
0.77A18.77
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1JQD_A_HSMA600_1
(HISTAMINE
N-METHYLTRANSFERASE)		1jqe HISTAMINE
N-METHYLTRANSFERASE
(Homo
sapiens)		7 / 7PHE A  22
GLU A  28
GLN A 143
VAL A 173
TRP A 179
TRP A 183
ASN A 283
None
None
None
None
QUN  A 500 (-3.6A)
QUN  A 500 (-4.9A)
None
0.38A99.66
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1JQD_A_HSMA600_1
(HISTAMINE
N-METHYLTRANSFERASE)		1jqe HISTAMINE
N-METHYLTRANSFERASE
(Homo
sapiens)		4 / 7PHE A 243
GLN A 143
VAL A 173
TRP A 179
QUN  A 500 (-4.1A)
None
None
QUN  A 500 (-3.6A)
1.20A99.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JQD_A_HSMA600_1
(HISTAMINE
N-METHYLTRANSFERASE)		2v5n CATION-INDEPENDENT
MANNOSE-6-PHOSPHATE
RECEPTOR
(Homo
sapiens)		4 / 7PHE A1527
GLU A1647
GLN A1648
ASN A1520
None
1.40A22.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JQD_A_HSMA600_1
(HISTAMINE
N-METHYLTRANSFERASE)		3eq1 PORPHOBILINOGEN
DEAMINASE
(Homo
sapiens)		4 / 7PHE A 158
GLU A 210
GLN A 204
VAL A 123
None
1.47A21.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JQD_A_HSMA600_1
(HISTAMINE
N-METHYLTRANSFERASE)		4ymd COLLECTIN-11
(Homo
sapiens)		4 / 7PHE A 225
GLU A 183
TRP A 251
ASN A 186
None
1.03A19.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JQD_A_HSMA600_1
(HISTAMINE
N-METHYLTRANSFERASE)		5ftg CHOLINE KINASE ALPHA
(Homo
sapiens)		4 / 7GLN A 308
TRP A 420
TRP A 423
ASN A 345
NBR  A1458 ( 3.3A)
NBR  A1458 (-3.4A)
NBR  A1458 ( 3.5A)
NBR  A1458 ( 4.9A)
1.14A24.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1JQD_B_HSMB601_1
(HISTAMINE
N-METHYLTRANSFERASE)		1jqe HISTAMINE
N-METHYLTRANSFERASE
(Homo
sapiens)		10 / 10PHE A  22
GLU A  28
GLN A 143
TYR A 146
VAL A 173
TRP A 179
TRP A 183
PHE A 243
ASN A 283
LEU A 285
None
None
None
QUN  A 500 (-3.3A)
None
QUN  A 500 (-3.6A)
QUN  A 500 (-4.9A)
QUN  A 500 (-4.1A)
None
None
0.37A99.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KAR_A_HSMA502_1
(HISTIDINOL
DEHYDROGENASE)		4xii CHOLINESTERASE
(Homo
sapiens)		5 / 9HIS A 126
ASP A 454
TYR A 456
GLU A 443
LEU A 448
None
1.30A21.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KAR_A_HSMA502_1
(HISTIDINOL
DEHYDROGENASE)		5k1c UBIQUITIN
CARBOXYL-TERMINAL
HYDROLASE 12
WD REPEAT-CONTAINING
PROTEIN 48
(Homo
sapiens)		5 / 9SER B 170
HIS A 243
TYR B 172
GLU A 241
LEU A 187
None
1.34A22.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KAR_B_HSMB503_1
(HISTIDINOL
DEHYDROGENASE)		4xii CHOLINESTERASE
(Homo
sapiens)		5 / 9GLU A 443
LEU A 448
HIS A 126
ASP A 454
TYR A 456
None
1.27A21.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KAR_B_HSMB503_1
(HISTIDINOL
DEHYDROGENASE)		5k1c UBIQUITIN
CARBOXYL-TERMINAL
HYDROLASE 12
WD REPEAT-CONTAINING
PROTEIN 48
(Homo
sapiens)		5 / 9GLU A 241
LEU A 187
SER B 170
HIS A 243
TYR B 172
None
1.31A20.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NP1_A_HSMA303_1
(NITROPHORIN 1)		2dh3 4F2 CELL-SURFACE
ANTIGEN HEAVY CHAIN
(Homo
sapiens)		4 / 5GLU A 504
LEU A 522
LEU A 496
LEU A 523
None
1.08A17.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NP1_A_HSMA303_1
(NITROPHORIN 1)		2jgn ATP-DEPENDENT RNA
HELICASE DDX3X
(Homo
sapiens)		4 / 5GLU A 561
LEU A 555
LEU A 558
LEU A 556
None
0.95A22.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NP1_A_HSMA303_1
(NITROPHORIN 1)		2mpc PYRIN
(Homo
sapiens)		4 / 5GLU A  84
LEU A  82
LEU A  81
LEU A  86
None
1.16A18.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NP1_A_HSMA303_1
(NITROPHORIN 1)		2v40 ADENYLOSUCCINATE
SYNTHETASE ISOZYME 2
(Homo
sapiens)		4 / 5ASP A 212
GLU A 214
LEU A 220
LEU A 217
None
1.07A19.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NP1_A_HSMA303_1
(NITROPHORIN 1)		3f2k HISTONE-LYSINE
N-METHYLTRANSFERASE
SETMAR
(Homo
sapiens)		4 / 5GLU A 150
LEU A 128
LEU A 152
LEU A 127
None
1.05A21.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NP1_A_HSMA303_1
(NITROPHORIN 1)		3isu RAS
GTPASE-ACTIVATING-LI
KE PROTEIN IQGAP3
(Homo
sapiens)		4 / 5GLU A1602
LEU A1596
LEU A1599
LEU A1597
None
1.15A20.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NP1_A_HSMA303_1
(NITROPHORIN 1)		3pfs BROMODOMAIN AND PHD
FINGER-CONTAINING
PROTEIN 3
(Homo
sapiens)		4 / 5ASP A1163
GLU A1159
LEU A1154
LEU A1156
None
1.09A22.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NP1_A_HSMA303_1
(NITROPHORIN 1)		4fl3 TYROSINE-PROTEIN
KINASE SYK
(Homo
sapiens)		4 / 5GLU A 452
LEU A 502
LEU A 453
LEU A 501
None
None
None
ANP  A 701 (-4.5A)
1.12A14.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NP1_A_HSMA303_1
(NITROPHORIN 1)		4jmk DUAL SPECIFICITY
PROTEIN PHOSPHATASE
8
(Homo
sapiens)		4 / 5GLU A 297
LEU A 303
LEU A 300
LEU A 302
None
1.01A21.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NP1_A_HSMA303_1
(NITROPHORIN 1)		4nnd TYROSINE-PROTEIN
PHOSPHATASE
NON-RECEPTOR TYPE 18
(Homo
sapiens)		4 / 5ASP A 114
LEU A  77
LEU A  78
LEU A  75
None
0.93A18.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NP1_A_HSMA303_1
(NITROPHORIN 1)		4p7h MYOSIN-7,GREEN
FLUORESCENT PROTEIN
(Aequorea
victoria;
Homo
sapiens)		4 / 5GLU A 775
LEU A 769
LEU A 772
LEU A 770
None
1.17A12.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NP1_A_HSMA303_1
(NITROPHORIN 1)		4q2q TIGHT JUNCTION
PROTEIN ZO-1
(Homo
sapiens)		4 / 5GLU A 481
LEU A 487
LEU A 484
LEU A 486
None
0.99A19.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NP1_A_HSMA303_1
(NITROPHORIN 1)		4um2 TELOMERASE-BINDING
PROTEIN EST1A
(Homo
sapiens)		4 / 5GLU A 680
LEU A 674
LEU A 677
LEU A 675
None
1.00A16.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NP1_A_HSMA303_1
(NITROPHORIN 1)		4wbp CAPRIN-1
(Homo
sapiens)		4 / 5GLU A 180
LEU A 186
LEU A 183
LEU A 185
None
1.04A20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NP1_A_HSMA303_1
(NITROPHORIN 1)		4xwh ALPHA-N-ACETYLGLUCOS
AMINIDASE
(Homo
sapiens)		4 / 5ASP A 607
LEU A 663
LEU A 618
LEU A 610
None
1.05A12.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NP1_A_HSMA303_1
(NITROPHORIN 1)		5v1m U6 SNRNA
PHOSPHODIESTERASE
(Homo
sapiens)		4 / 5GLU A  93
LEU A  99
LEU A  96
LEU A  98
None
0.98A22.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NP1_A_HSMA303_1
(NITROPHORIN 1)		5y3r DNA-DEPENDENT
PROTEIN KINASE
CATALYTIC SUBUNIT
(Homo
sapiens)		4 / 5ASP C3354
GLU C3350
LEU C3298
LEU C3348
None
1.01A4.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NP1_A_HSMA303_1
(NITROPHORIN 1)		5y3r DNA-DEPENDENT
PROTEIN KINASE
CATALYTIC SUBUNIT
(Homo
sapiens)		4 / 5GLU C  17
LEU C  12
LEU C  13
LEU C  15
None
1.14A4.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NP1_A_HSMA303_1
(NITROPHORIN 1)		6cet GATOR COMPLEX
PROTEIN NPRL3
(Homo
sapiens)		4 / 5ASP M 266
LEU M 261
LEU M 264
LEU M 262
None
1.16A19.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NP1_B_HSMB304_1
(NITROPHORIN 1)		1dr9 T LYMPHOCYTE
ACTIVATION ANTIGEN
(Homo
sapiens)		3 / 3ASP A  76
LEU A  70
LEU A  72
None
0.63A20.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NP1_B_HSMB304_1
(NITROPHORIN 1)		1ji7 ETS-RELATED PROTEIN
TEL1
(Homo
sapiens)		3 / 3ASP A  69
LEU A  64
LEU A  65
None
0.80A15.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NP1_B_HSMB304_1
(NITROPHORIN 1)		2byf PHOSPHOLIPASE C,
EPSILON 1
(Homo
sapiens)		3 / 3ASP A  13
LEU A 105
LEU A 103
None
0.72A21.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NP1_B_HSMB304_1
(NITROPHORIN 1)		2l4c ENDOPLASMIC
RETICULUM RESIDENT
PROTEIN 27
(Homo
sapiens)		3 / 3ASP A  98
LEU A  92
LEU A  94
None
0.59A23.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NP1_B_HSMB304_1
(NITROPHORIN 1)		2p8u HYDROXYMETHYLGLUTARY
L-COA SYNTHASE,
CYTOPLASMIC
(Homo
sapiens)		3 / 3ASP A 282
LEU A 275
LEU A 279
None
0.70A19.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NP1_B_HSMB304_1
(NITROPHORIN 1)		2yua WILLIAMS-BEUREN
SYNDROME CHROMOSOME
REGION 18 PROTEIN
(Homo
sapiens)		3 / 3ASP A  88
LEU A  83
LEU A  84
None
0.80A20.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NP1_B_HSMB304_1
(NITROPHORIN 1)		3vn9 DUAL SPECIFICITY
MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE 6
(Homo
sapiens)		3 / 3ASP A 239
LEU A 169
LEU A 166
None
0.69A21.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NP1_B_HSMB304_1
(NITROPHORIN 1)		3wig DUAL SPECIFICITY
MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE 1
(Homo
sapiens)		3 / 3ASP A 246
LEU A 181
LEU A 178
None
0.79A19.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NP1_B_HSMB304_1
(NITROPHORIN 1)		4igm 2-AMINO-3-CARBOXYMUC
ONATE-6-SEMIALDEHYDE
DECARBOXYLASE
(Homo
sapiens)		3 / 3ASP A 279
LEU A 272
LEU A 276
None
0.57A18.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NP1_B_HSMB304_1
(NITROPHORIN 1)		4j0w U3 SMALL NUCLEOLAR
RNA-INTERACTING
PROTEIN 2
(Homo
sapiens)		3 / 3ASP A 290
LEU A 386
LEU A 332
None
0.72A17.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NP1_B_HSMB304_1
(NITROPHORIN 1)		4mhl INTERLEUKIN-11
(Homo
sapiens)		3 / 3ASP A  52
LEU A  45
LEU A  49
SO4  A 201 (-4.3A)
None
None
0.52A18.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NP1_B_HSMB304_1
(NITROPHORIN 1)		5btr NAD-DEPENDENT
PROTEIN DEACETYLASE
SIRTUIN-1
(Homo
sapiens)		3 / 3ASP A 334
LEU A 340
LEU A 339
None
0.80A18.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NP1_B_HSMB304_1
(NITROPHORIN 1)		5l0p TRANSCRIPTION FACTOR
ETV6, TRANSCRIPTION
FACTOR ETV6,
TRANSCRIPTION FACTOR
ETV6, FERRIC UPTAKE
REGULATION PROTEIN
CHIMERA
(Homo
sapiens;
Klebsiella
pneumoniae)		3 / 3ASP A  65
LEU A  60
LEU A  61
None
0.74A19.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NP1_B_HSMB304_1
(NITROPHORIN 1)		5l0p TRANSCRIPTION FACTOR
ETV6, TRANSCRIPTION
FACTOR ETV6,
TRANSCRIPTION FACTOR
ETV6, FERRIC UPTAKE
REGULATION PROTEIN
CHIMERA
(Homo
sapiens;
Klebsiella
pneumoniae)		3 / 3ASP A 236
LEU A 231
LEU A 232
None
0.74A19.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NP1_B_HSMB304_1
(NITROPHORIN 1)		5mv9 UNCONVENTIONAL
MYOSIN-VIIA
(Homo
sapiens)		3 / 3ASP A1811
LEU A1851
LEU A1850
None
0.72A17.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NP1_B_HSMB304_1
(NITROPHORIN 1)		5xbf UNCONVENTIONAL
MYOSIN-VIIB
(Homo
sapiens)		3 / 3ASP A1708
LEU A1748
LEU A1747
None
0.70A16.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NP1_B_HSMB304_1
(NITROPHORIN 1)		5xfo PHD FINGER PROTEIN 1
(Homo
sapiens)		3 / 3ASP A 253
LEU A 247
LEU A 249
None
0.69A19.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NP1_B_HSMB304_1
(NITROPHORIN 1)		5xfr METAL-RESPONSE
ELEMENT-BINDING
TRANSCRIPTION FACTOR
2
(Homo
sapiens)		3 / 3ASP A 268
LEU A 262
LEU A 264
None
0.72A19.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NP1_B_HSMB304_1
(NITROPHORIN 1)		6c9m N-ALPHA-ACETYLTRANSF
ERASE 15, NATA
AUXILIARY SUBUNIT
(Homo
sapiens)		3 / 3ASP A 363
LEU A 353
LEU A 358
None
0.79A18.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NP1_B_HSMB304_1
(NITROPHORIN 1)		6ejb XYLOSYLTRANSFERASE 1
(Homo
sapiens)		3 / 3ASP A 764
LEU A 759
LEU A 760
None
0.80A20.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QFT_A_HSMA176_1
(PROTEIN
(FEMALE-SPECIFIC
HISTAMINE BINDING
PROTEIN 2))		4rer 5'-AMP-ACTIVATED
PROTEIN KINASE
SUBUNIT BETA-2
5'-AMP-ACTIVATED
PROTEIN KINASE
SUBUNIT GAMMA-1
(Homo
sapiens)		5 / 9SER G 160
TYR B 259
VAL B 264
ASP G 157
ILE G 156
None
1.37A19.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QFT_B_HSMB176_1
(PROTEIN
(FEMALE-SPECIFIC
HISTAMINE BINDING
PROTEIN 2))		4rer 5'-AMP-ACTIVATED
PROTEIN KINASE
SUBUNIT BETA-2
5'-AMP-ACTIVATED
PROTEIN KINASE
SUBUNIT GAMMA-1
(Homo
sapiens)		5 / 9SER G 160
TYR B 259
VAL B 264
ASP G 157
ILE G 156
None
1.38A19.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1U18_A_HSMA401_1
(NITROPHORIN 1)		1fyv TOLL-LIKE RECEPTOR 1
(Homo
sapiens)		4 / 4ASP A 647
LEU A 730
LEU A 697
LEU A 731
None
1.23A17.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1U18_A_HSMA401_1
(NITROPHORIN 1)		1n0w DNA REPAIR PROTEIN
RAD51 HOMOLOG 1
(Homo
sapiens)		4 / 4ASP A 257
LEU A 252
LEU A 255
LEU A 253
None
1.39A20.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1U18_A_HSMA401_1
(NITROPHORIN 1)		1o77 TOLL-LIKE RECEPTOR 2
(Homo
sapiens)		4 / 4ASP A 651
LEU A 736
LEU A 703
LEU A 737
None
1.23A18.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1U18_A_HSMA401_1
(NITROPHORIN 1)		1u6g TIP120 PROTEIN
(Homo
sapiens)		4 / 4ASP C 824
LEU C 840
LEU C 837
LEU C 839
None
1.40A8.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1U18_A_HSMA401_1
(NITROPHORIN 1)		2a14 INDOLETHYLAMINE
N-METHYLTRANSFERASE
(Homo
sapiens)		4 / 4ASP A  61
LEU A 193
LEU A 183
LEU A 161
None
1.42A24.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1U18_A_HSMA401_1
(NITROPHORIN 1)		2j67 TOLL LIKE RECEPTOR
10
(Homo
sapiens)		4 / 4ASP A 644
LEU A 729
LEU A 696
LEU A 730
None
1.28A20.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1U18_A_HSMA401_1
(NITROPHORIN 1)		2m1w TIR
DOMAIN-CONTAINING
ADAPTER MOLECULE 2
(Homo
sapiens)		4 / 4ASP A  89
LEU A 139
LEU A 180
LEU A 138
None
1.29A18.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1U18_A_HSMA401_1
(NITROPHORIN 1)		4fdh CYTOCHROME P450
11B2, MITOCHONDRIAL
(Homo
sapiens)		4 / 4ASP A 147
LEU A 294
LEU A 295
LEU A 293
None
1.25A16.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1U18_A_HSMA401_1
(NITROPHORIN 1)		4nnd TYROSINE-PROTEIN
PHOSPHATASE
NON-RECEPTOR TYPE 18
(Homo
sapiens)		4 / 4ASP A 114
LEU A  77
LEU A  78
LEU A  75
None
0.99A17.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1U18_A_HSMA401_1
(NITROPHORIN 1)		4om7 TOLL-LIKE RECEPTOR 6
(Homo
sapiens)		4 / 4ASP A 652
LEU A 735
LEU A 702
LEU A 736
None
1.23A18.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1U18_A_HSMA401_1
(NITROPHORIN 1)		4um2 TELOMERASE-BINDING
PROTEIN EST1A
(Homo
sapiens)		4 / 4ASP A 679
LEU A 674
LEU A 677
LEU A 675
None
1.38A16.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1U18_A_HSMA401_1
(NITROPHORIN 1)		4xwh ALPHA-N-ACETYLGLUCOS
AMINIDASE
(Homo
sapiens)		4 / 4ASP A 607
LEU A 663
LEU A 618
LEU A 610
None
1.09A12.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1U18_A_HSMA401_1
(NITROPHORIN 1)		4zfh ARTIFICIAL ANKYRIN
REPEAT
PROTEIN_ANK(GAG)1D4
MUTANT -Y56A
(Homo
sapiens)		4 / 4ASP A  13
LEU A  18
LEU A  19
LEU A  14
None
1.34A27.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1U18_A_HSMA401_1
(NITROPHORIN 1)		5ggg PROTEIN
O-LINKED-MANNOSE
BETA-1,2-N-ACETYLGLU
COSAMINYLTRANSFERASE
1
(Homo
sapiens)		4 / 4ASP A 436
LEU A 440
LEU A 530
LEU A 439
None
1.42A15.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1U18_A_HSMA401_1
(NITROPHORIN 1)		5h1c DNA REPAIR PROTEIN
RAD51 HOMOLOG 1
(Homo
sapiens)		4 / 4ASP A 257
LEU A 252
LEU A 255
LEU A 253
None
1.38A20.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1U18_A_HSMA401_1
(NITROPHORIN 1)		5jcp ARF-GAP WITH RHO-GAP
DOMAIN, ANK REPEAT
AND PH
DOMAIN-CONTAINING
PROTEIN
3,LINKER,TRANSFORMIN
G PROTEIN RHOA
(Homo
sapiens;
synthetic
construct)		4 / 4ASP B 975
LEU B 954
LEU B 951
LEU B 953
None
1.22A18.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1U18_A_HSMA401_1
(NITROPHORIN 1)		5le0 PROTEIN-METHIONINE
SULFOXIDE OXIDASE
MICAL1
(Homo
sapiens)		4 / 4ASP B 979
LEU B 974
LEU B 977
LEU B 975
None
1.30A21.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1U18_A_HSMA401_1
(NITROPHORIN 1)		5mio KINESIN-LIKE PROTEIN
KIF2C,KIF2C FUSED TO
A DARPIN,KIF2C FUSED
TO A DARPIN
(Homo
sapiens)		4 / 4ASP C 622
LEU C 627
LEU C 628
LEU C 623
None
1.34A17.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1U18_A_HSMA401_1
(NITROPHORIN 1)		5uj7 ORIGIN RECOGNITION
COMPLEX SUBUNIT 4
(Homo
sapiens)		4 / 4ASP C 197
LEU C 202
LEU C 199
LEU C 201
None
1.39A18.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1U18_A_HSMA401_1
(NITROPHORIN 1)		6cet GATOR COMPLEX
PROTEIN NPRL3
(Homo
sapiens)		4 / 4ASP M 266
LEU M 261
LEU M 264
LEU M 262
None
1.16A19.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1U18_B_HSMB402_1
(NITROPHORIN 1)		1kcw CERULOPLASMIN
(Homo
sapiens)		5 / 5ASP A 576
GLU A 575
THR A 532
LEU A 572
LEU A 573
None
1.07A10.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1U18_B_HSMB402_1
(NITROPHORIN 1)		1ly7 FRATAXIN
(Homo
sapiens)		4 / 5GLU A 189
THR A 196
LEU A 198
LEU A 194
None
0.92A22.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1U18_B_HSMB402_1
(NITROPHORIN 1)		1p49 STERYL-SULFATASE
(Homo
sapiens)		4 / 5ASP A 169
GLU A 174
THR A 165
LEU A 167
None
None
ALS  A  75 ( 3.8A)
None
1.14A15.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1U18_B_HSMB402_1
(NITROPHORIN 1)		1snl NUCLEOBINDIN 1
(Homo
sapiens)		4 / 5ASP A  30
GLU A  37
THR A  86
LEU A  84
None
1.18A22.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1U18_B_HSMB402_1
(NITROPHORIN 1)		1t6n PROBABLE
ATP-DEPENDENT RNA
HELICASE
(Homo
sapiens)		4 / 5GLU A  55
THR A 103
LEU A 107
LEU A 104
None
1.23A20.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1U18_B_HSMB402_1
(NITROPHORIN 1)		1z0a RAS-RELATED PROTEIN
RAB-2A
(Homo
sapiens)		4 / 5ASP A  61
THR A  27
LEU A  24
LEU A  23
 MG  A1201 (-3.0A)
None
None
None
1.19A22.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1U18_B_HSMB402_1
(NITROPHORIN 1)		2iae SERINE/THREONINE-PRO
TEIN PHOSPHATASE 2A
56 KDA REGULATORY
SUBUNIT GAMMA
ISOFORM
(Homo
sapiens)		4 / 5GLU B 226
THR B 185
LEU B 186
LEU B 182
None
1.15A17.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1U18_B_HSMB402_1
(NITROPHORIN 1)		2wnt RIBOSOMAL PROTEIN S6
KINASE
(Homo
sapiens)		4 / 5ASP A 596
GLU A 593
THR A 522
LEU A 526
None
1.23A20.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1U18_B_HSMB402_1
(NITROPHORIN 1)		3nf1 KINESIN LIGHT CHAIN
1
(Homo
sapiens)		4 / 5GLU A 487
THR A 466
LEU A 470
LEU A 467
None
1.02A20.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1U18_B_HSMB402_1
(NITROPHORIN 1)		4k6j WINGS APART-LIKE
PROTEIN HOMOLOG
(Homo
sapiens)		4 / 5GLU A 859
THR A 941
LEU A 937
LEU A 940
None
1.01A15.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1U18_B_HSMB402_1
(NITROPHORIN 1)		4u7l LEUCINE-RICH REPEATS
AND
IMMUNOGLOBULIN-LIKE
DOMAINS PROTEIN 1
(Homo
sapiens)		4 / 5GLU A  49
THR A  30
LEU A  54
LEU A  26
None
1.14A16.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1U18_B_HSMB402_1
(NITROPHORIN 1)		5muf SERINE/THREONINE-PRO
TEIN PHOSPHATASE
PGAM5, MITOCHONDRIAL
(Homo
sapiens)		4 / 5GLU A 129
THR A 121
LEU A 123
LEU A 120
None
1.22A20.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1U18_B_HSMB402_1
(NITROPHORIN 1)		6fuz KINESIN LIGHT CHAIN
1,KINESIN LIGHT
CHAIN
1,C-JUN-AMINO-TERMIN
AL
KINASE-INTERACTING
PROTEIN 1
(Homo
sapiens;
Mus
musculus)		4 / 5GLU A 487
THR A 466
LEU A 470
LEU A 467
None
0.85A18.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QEB_A_HSMA145_1
(D7R4 PROTEIN)		1b4j ANTIBODY
(Homo
sapiens)		4 / 7ILE L 106
TYR L  12
TYR L 140
GLU L 165
None
1.16A21.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QEB_A_HSMA145_1
(D7R4 PROTEIN)		1kt8 BRANCHED-CHAIN AMINO
ACID
AMINOTRANSFERASE,
MITOCHONDRIAL
(Homo
sapiens)		4 / 7ARG A 344
TYR A 246
PHE A 284
GLU A 283
None
1.02A17.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QEB_A_HSMA145_1
(D7R4 PROTEIN)		1zli CARBOXYPEPTIDASE B
(Homo
sapiens)		4 / 7ILE A 183
ARG A 184
PHE A 147
GLU A 171
None
1.07A20.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QEB_A_HSMA145_1
(D7R4 PROTEIN)		2abj BRANCHED-CHAIN-AMINO
-ACID
AMINOTRANSFERASE,
CYTOSOLIC
(Homo
sapiens)		5 / 7ILE A 363
ARG A 362
TYR A 264
PHE A 302
GLU A 301
None
0.98A17.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QEB_A_HSMA145_1
(D7R4 PROTEIN)		2xa0 APOPTOSIS REGULATOR
BCL-2
(Homo
sapiens)		4 / 7ILE A  19
TYR A  21
ASP A 102
GLU A 152
None
1.15A16.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QEB_A_HSMA145_1
(D7R4 PROTEIN)		4lxl LYSINE-SPECIFIC
DEMETHYLASE 4B
(Homo
sapiens)		4 / 7ILE A 261
PHE A 115
ASP A 116
GLU A 119
None
1.07A16.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QEB_A_HSMA145_1
(D7R4 PROTEIN)		4mh0 RAP GUANINE
NUCLEOTIDE EXCHANGE
FACTOR 4
RAS-RELATED PROTEIN
RAP-1B
(Homo
sapiens;
Mus
musculus)		4 / 7ILE R  36
ARG E 892
TYR R  40
TYR R  32
None
1.00A22.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QEB_A_HSMA145_1
(D7R4 PROTEIN)		5dot CARBAMOYL-PHOSPHATE
SYNTHASE [AMMONIA],
MITOCHONDRIAL
(Homo
sapiens)		4 / 7ILE A 100
PHE A 877
ASP A 874
GLU A 651
None
1.03A6.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QEB_A_HSMA145_1
(D7R4 PROTEIN)		5iy7 TATA-BOX-BINDING
PROTEIN
TRANSCRIPTION
INITIATION FACTOR
IIB
(Homo
sapiens)		4 / 7ILE M 166
ARG M 169
PHE M 177
GLU P 284
None
1.12A16.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QEB_B_HSMB145_1
(D7R4 PROTEIN)		1b4j ANTIBODY
(Homo
sapiens)		4 / 7ILE L 106
TYR L  12
TYR L 140
GLU L 165
None
1.16A21.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QEB_B_HSMB145_1
(D7R4 PROTEIN)		1kt8 BRANCHED-CHAIN AMINO
ACID
AMINOTRANSFERASE,
MITOCHONDRIAL
(Homo
sapiens)		4 / 7ARG A 344
TYR A 246
PHE A 284
GLU A 283
None
1.04A17.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QEB_B_HSMB145_1
(D7R4 PROTEIN)		1zli CARBOXYPEPTIDASE B
(Homo
sapiens)		4 / 7ILE A 183
ARG A 184
PHE A 147
GLU A 171
None
1.02A20.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QEB_B_HSMB145_1
(D7R4 PROTEIN)		2abj BRANCHED-CHAIN-AMINO
-ACID
AMINOTRANSFERASE,
CYTOSOLIC
(Homo
sapiens)		5 / 7ILE A 363
ARG A 362
TYR A 264
PHE A 302
GLU A 301
None
1.00A17.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QEB_B_HSMB145_1
(D7R4 PROTEIN)		2xa0 APOPTOSIS REGULATOR
BCL-2
(Homo
sapiens)		4 / 7ILE A  19
TYR A  21
ASP A 102
GLU A 152
None
1.14A16.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QEB_B_HSMB145_1
(D7R4 PROTEIN)		4lxl LYSINE-SPECIFIC
DEMETHYLASE 4B
(Homo
sapiens)		4 / 7ILE A 261
PHE A 115
ASP A 116
GLU A 119
None
1.07A16.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QEB_B_HSMB145_1
(D7R4 PROTEIN)		4mh0 RAP GUANINE
NUCLEOTIDE EXCHANGE
FACTOR 4
RAS-RELATED PROTEIN
RAP-1B
(Homo
sapiens;
Mus
musculus)		4 / 7ILE R  36
ARG E 892
TYR R  40
TYR R  32
None
1.00A22.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X45_A_HSMA1160_1
(ALLERGEN ARG R 1)		1cdz PROTEIN (DNA-REPAIR
PROTEIN XRCC1)
(Homo
sapiens)		4 / 6SER A  56
TYR A  14
VAL A  47
ASP A  54
None
1.39A20.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X45_A_HSMA1160_1
(ALLERGEN ARG R 1)		5k1c WD REPEAT-CONTAINING
PROTEIN 20
(Homo
sapiens)		4 / 6SER C 171
TYR C 175
VAL C 167
ASP C 148
None
1.33A13.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X45_A_HSMA1160_1
(ALLERGEN ARG R 1)		5tur SERINE/THREONINE-PRO
TEIN KINASE PIM-1
(Homo
sapiens)		4 / 6SER A  59
VAL A  64
TYR A  38
ASP A  60
None
1.41A12.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X45_A_HSMA1160_1
(ALLERGEN ARG R 1)		5xtw MACROPHAGE MANNOSE
RECEPTOR 1
(Homo
sapiens)		4 / 6SER A 256
VAL A 228
TYR A 230
ASP A 294
None
1.49A17.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X45_A_HSMA1161_1
(ALLERGEN ARG R 1)		1eih EOTAXIN-2
(Homo
sapiens)		4 / 5VAL A  56
TYR A  59
VAL A  21
SER A  47
None
1.23A15.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X45_A_HSMA1161_1
(ALLERGEN ARG R 1)		1tnr TUMOR NECROSIS
FACTOR BETA
(Homo
sapiens)		4 / 5VAL A  75
TYR A  73
VAL A  67
ASP A 145
None
1.16A17.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X45_A_HSMA1161_1
(ALLERGEN ARG R 1)		1x5d PROTEIN
DISULFIDE-ISOMERASE
A6
(Homo
sapiens)		4 / 5VAL A  30
VAL A  21
ASP A  18
SER A  16
None
1.27A20.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X45_A_HSMA1161_1
(ALLERGEN ARG R 1)		2dmy SPERMATID
PERINUCLEAR
RNA-BINDING PROTEIN
(Homo
sapiens)		4 / 5VAL A  73
TYR A  59
VAL A  54
ASP A  53
None
0.97A18.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X45_A_HSMA1161_1
(ALLERGEN ARG R 1)		2ozu HISTONE
ACETYLTRANSFERASE
MYST3
(Homo
sapiens)		4 / 5VAL A 617
TYR A 616
ASP A 582
SER A 586
None
1.31A16.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X45_A_HSMA1161_1
(ALLERGEN ARG R 1)		2v55 RHO-ASSOCIATED
PROTEIN KINASE 1
(Homo
sapiens)		4 / 5VAL A 101
TYR A 155
ASP A 364
SER A 361
None
ANP  A1480 ( 4.9A)
None
None
1.31A14.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X45_A_HSMA1161_1
(ALLERGEN ARG R 1)		2vc2 INTEGRIN ALPHA-IIB
(Homo
sapiens)		4 / 5VAL A 241
TYR A 253
VAL A 182
SER A 172
None
1.29A14.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X45_A_HSMA1161_1
(ALLERGEN ARG R 1)		2xra HK20, HUMAN
MONOCLONAL ANTIBODY
HEAVY CHAIN
(Homo
sapiens)		4 / 5VAL H 211
TYR H 194
VAL H 184
SER H 130
None
1.19A23.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X45_A_HSMA1161_1
(ALLERGEN ARG R 1)		3l5h INTERLEUKIN-6
RECEPTOR SUBUNIT
BETA
(Homo
sapiens)		4 / 5TYR A 555
VAL A 548
ASP A 549
SER A 551
None
1.20A12.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X45_A_HSMA1161_1
(ALLERGEN ARG R 1)		3vzb SPHINGOSINE KINASE 1
(Homo
sapiens)		4 / 5VAL A 260
TYR A 289
VAL A 252
ASP A 254
None
1.06A16.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X45_A_HSMA1161_1
(ALLERGEN ARG R 1)		4d9r COMPLEMENT FACTOR D
(Homo
sapiens)		4 / 5VAL A  45
TYR A  29
VAL A 200
ASP A 137
None
1.17A19.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X45_A_HSMA1161_1
(ALLERGEN ARG R 1)		4gwr PROTEIN
DISULFIDE-ISOMERASE
A6
(Homo
sapiens)		4 / 5VAL A 183
VAL A 174
ASP A 171
SER A 169
None
1.25A21.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X45_A_HSMA1161_1
(ALLERGEN ARG R 1)		4idj FAB HEAVY CHAIN
(Homo
sapiens)		4 / 5VAL H 121
VAL H 150
ASP H 199
SER H 153
None
1.01A22.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X45_A_HSMA1161_1
(ALLERGEN ARG R 1)		5ei0 SERPIN A12
(Homo
sapiens)		4 / 5VAL A 249
TYR A 247
VAL A 306
ASP A 305
None
1.03A15.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X45_A_HSMA1161_1
(ALLERGEN ARG R 1)		5ggg PROTEIN
O-LINKED-MANNOSE
BETA-1,2-N-ACETYLGLU
COSAMINYLTRANSFERASE
1
(Homo
sapiens)		4 / 5VAL A 278
TYR A 275
VAL A 347
ASP A 346
None
1.01A15.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X45_A_HSMA1161_1
(ALLERGEN ARG R 1)		5lb3 ATP-DEPENDENT DNA
HELICASE Q5
(Homo
sapiens)		4 / 5VAL B 162
TYR B 173
VAL B 156
ASP B 157
None
None
None
MG  B 503 ( 4.0A)
1.16A15.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X45_A_HSMA1161_1
(ALLERGEN ARG R 1)		5txk UBIQUITIN
CARBOXYL-TERMINAL
HYDROLASE
35,UBIQUITIN
CARBOXYL-TERMINAL
HYDROLASE 35
(Homo
sapiens)		4 / 5VAL A 850
TYR A 866
VAL A 909
ASP A 916
None
0.92A17.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X45_A_HSMA1161_1
(ALLERGEN ARG R 1)		6d4j PROTEIN PATCHED
HOMOLOG 1
(Homo
sapiens)		4 / 5VAL A 477
VAL A 510
ASP A 513
SER A1132
None
1.24A17.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X45_A_HSMA1161_1
(ALLERGEN ARG R 1)		6en4 SPLICING FACTOR 3B
SUBUNIT 3
(Homo
sapiens)		4 / 5VAL A 959
TYR A 970
VAL A 925
SER A 890
None
0.87A17.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X45_A_HSMA1162_1
(ALLERGEN ARG R 1)		1kwm PROCARBOXYPEPTIDASE
B
(Homo
sapiens)		4 / 4GLU A 270
ASP A 142
HIS A  69
GLU A  72
None
None
ZN  A 400 (-3.9A)
ZN  A 400 (-2.1A)
1.18A14.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X45_A_HSMA1162_1
(ALLERGEN ARG R 1)		3she MAP KINASE-ACTIVATED
PROTEIN KINASE 3
(Homo
sapiens)		4 / 4GLU A 334
ASP A 324
HIS A 327
GLU A 330
None
1.32A19.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X45_B_HSMB1160_1
(ALLERGEN ARG R 1)		1lbk GLUTATHIONE
S-TRANSFERASE CLASS
PI CHIMAERA (CODA)
(Homo
sapiens)		4 / 7SER A 149
TYR A 153
TYR A 179
ILE A 143
None
1.20A21.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X45_B_HSMB1160_1
(ALLERGEN ARG R 1)		2crw ADP-RIBOSYLATION
FACTOR
GTPASE-ACTIVATING
PROTEIN 3
(Homo
sapiens)		4 / 7SER A  67
TYR A  47
VAL A  49
ILE A  69
None
1.25A19.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X45_B_HSMB1160_1
(ALLERGEN ARG R 1)		2f4w UBIQUITIN-CONJUGATIN
G ENZYME E2, J2
(Homo
sapiens)		4 / 7SER A 146
TYR A  61
VAL A  47
ILE A 167
None
1.24A24.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X45_B_HSMB1160_1
(ALLERGEN ARG R 1)		2wbi ACYL-COA
DEHYDROGENASE FAMILY
MEMBER 11
(Homo
sapiens)		4 / 7SER A 325
VAL A 376
ILE A 322
TRP A 321
None
1.21A16.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X45_B_HSMB1160_1
(ALLERGEN ARG R 1)		3pdf DIPEPTIDYL PEPTIDASE
1
(Homo
sapiens)		4 / 7TYR A 321
VAL A 431
TYR A 323
ILE A  63
None
None
CL  A 443 (-4.7A)
None
1.13A16.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X45_B_HSMB1160_1
(ALLERGEN ARG R 1)		4qti UROKINASE
PLASMINOGEN
ACTIVATOR SURFACE
RECEPTOR
(Homo
sapiens)		4 / 7VAL U 238
TYR U 236
ILE U 130
ASP U 163
None
1.05A18.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X45_B_HSMB1160_1
(ALLERGEN ARG R 1)		4wtv PHOSPHATIDYLINOSITOL
4-KINASE TYPE
2-BETA,ENDOLYSIN,PHO
SPHATIDYLINOSITOL
4-KINASE TYPE 2-BETA
(Escherichia
virus
T4;
Homo
sapiens)		4 / 7SER A 214
TYR A 134
VAL A 136
ILE A 117
None
1.26A13.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X45_B_HSMB1160_1
(ALLERGEN ARG R 1)		5cxv MUSCARINIC
ACETYLCHOLINE
RECEPTOR
M1,ENDOLYSIN,MUSCARI
NIC ACETYLCHOLINE
RECEPTOR M1
(Escherichia
virus
T4;
Homo
sapiens)		4 / 7SER A  78
TYR A 408
ILE A  73
ASP A 105
None
0HK  A 501 (-4.7A)
None
0HK  A 501 (-3.0A)
1.22A15.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X45_B_HSMB1160_1
(ALLERGEN ARG R 1)		5dsg MUSCARINIC
ACETYLCHOLINE
RECEPTOR
M4,ENDOLYSIN,ENDOLYS
IN,MUSCARINIC
ACETYLCHOLINE
RECEPTOR M4
(Escherichia
virus
T4;
Homo
sapiens)		4 / 7SER A  85
TYR A 439
ILE A  81
ASP A 112
None
0HK  A1201 (-3.6A)
None
0HK  A1201 (-4.0A)
1.26A16.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X45_B_HSMB1160_1
(ALLERGEN ARG R 1)		5j68 ASTROTACTIN-2
(Homo
sapiens)		4 / 7SER A1203
TYR A1189
VAL A1185
ILE A1215
None
1.05A14.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X45_B_HSMB1160_1
(ALLERGEN ARG R 1)		5m7r PROTEIN O-GLCNACASE
(Homo
sapiens)		4 / 7SER A 268
VAL A 228
ILE A 271
TRP A 249
None
1.19A9.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X45_B_HSMB1160_1
(ALLERGEN ARG R 1)		5n2d PROGRAMMED CELL
DEATH 1 LIGAND 1
(Homo
sapiens)		4 / 7TYR A  28
VAL A 128
TYR A 112
ILE A 101
None
1.22A15.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X45_B_HSMB1160_1
(ALLERGEN ARG R 1)		5sym ACYL-PROTEIN
THIOESTERASE 1
(Homo
sapiens)		4 / 7VAL A  24
TYR A  51
ILE A  44
ASP A 223
None
1.17A18.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X45_B_HSMB1160_1
(ALLERGEN ARG R 1)		5vvo PROTEIN O-GLCNACASE
(Homo
sapiens)		4 / 7SER A 268
VAL A 228
ILE A 271
TRP A 249
None
1.19A14.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X45_B_HSMB1161_1
(ALLERGEN ARG R 1)		1eih EOTAXIN-2
(Homo
sapiens)		4 / 4VAL A  56
TYR A  59
VAL A  21
SER A  47
None
1.30A15.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X45_B_HSMB1161_1
(ALLERGEN ARG R 1)		2vc2 INTEGRIN ALPHA-IIB
(Homo
sapiens)		4 / 4VAL A 241
TYR A 253
VAL A 182
SER A 172
None
1.24A14.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X45_B_HSMB1161_1
(ALLERGEN ARG R 1)		4hf5 FAB 8F8 HEAVY CHAIN
(Homo
sapiens)		4 / 4VAL H 100
TYR H 100
VAL H  33
SER H  55
None
1.32A21.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X45_B_HSMB1161_1
(ALLERGEN ARG R 1)		5nfn JMJC
DOMAIN-CONTAINING
PROTEIN 7
(Homo
sapiens)		4 / 4VAL A 235
TYR A 211
VAL A  94
SER A 176
None
1.43A16.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X45_B_HSMB1161_1
(ALLERGEN ARG R 1)		6en4 SPLICING FACTOR 3B
SUBUNIT 3
(Homo
sapiens)		4 / 4VAL A 959
TYR A 970
VAL A 925
SER A 890
None
0.92A17.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X45_B_HSMB1162_1
(ALLERGEN ARG R 1)		1dtd CARBOXYPEPTIDASE A2
(Homo
sapiens)		3 / 3GLU A 626
HIS A 424
GLU A 427
GLU  A 300 (-4.2A)
ZN  A 301 ( 3.4A)
ZN  A 301 (-2.6A)
0.82A18.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X45_B_HSMB1162_1
(ALLERGEN ARG R 1)		1kwm PROCARBOXYPEPTIDASE
B
(Homo
sapiens)		3 / 3GLU A 270
HIS A  69
GLU A  72
None
ZN  A 400 (-3.9A)
ZN  A 400 (-2.1A)
0.85A14.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X45_B_HSMB1162_1
(ALLERGEN ARG R 1)		1zli CARBOXYPEPTIDASE B
(Homo
sapiens)		3 / 3GLU A 270
HIS A  69
GLU A  72
 ZN  A 501 ( 4.8A)
ZN  A 501 (-3.1A)
ZN  A 501 (-2.1A)
0.78A18.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X45_B_HSMB1162_1
(ALLERGEN ARG R 1)		2k2o MYOFERLIN
(Homo
sapiens)		3 / 3GLU A 976
HIS A 927
GLU A 929
None
0.75A26.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X45_B_HSMB1162_1
(ALLERGEN ARG R 1)		2pcu CARBOXYPEPTIDASE A4
(Homo
sapiens)		3 / 3GLU A 270
HIS A  69
GLU A  72
 ZN  A 999 (-4.6A)
ZN  A 999 ( 3.1A)
ZN  A 999 (-2.1A)
0.79A17.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X45_B_HSMB1162_1
(ALLERGEN ARG R 1)		2uzx HEPATOCYTE GROWTH
FACTOR RECEPTOR
(Homo
sapiens)		3 / 3GLU B 493
HIS B  60
GLU B  75
None
0.77A10.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X45_B_HSMB1162_1
(ALLERGEN ARG R 1)		2y1h PUTATIVE
DEOXYRIBONUCLEASE
TATDN3
(Homo
sapiens)		3 / 3GLU A  44
HIS A 147
GLU A 107
PO4  A1275 (-3.2A)
ZN  A1273 ( 3.1A)
ZN  A1274 (-2.4A)
0.80A17.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X45_B_HSMB1162_1
(ALLERGEN ARG R 1)		3al2 DNA TOPOISOMERASE
2-BINDING PROTEIN 1
(Homo
sapiens)		3 / 3GLU A1296
HIS A1285
GLU A1288
None
0.81A21.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X45_B_HSMB1162_1
(ALLERGEN ARG R 1)		3fju CARBOXYPEPTIDASE A1
(Homo
sapiens)		3 / 3GLU A 270
HIS A  69
GLU A  72
ACT  A 515 (-4.3A)
ZN  A 999 ( 3.1A)
ZN  A 999 (-2.1A)
0.75A17.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X45_B_HSMB1162_1
(ALLERGEN ARG R 1)		3lms CARBOXYPEPTIDASE B2
(Homo
sapiens)		3 / 3GLU A 270
HIS A  69
GLU A  72
GLY  A 501 ( 4.6A)
ZN  A 309 ( 3.1A)
ZN  A 309 (-2.0A)
0.71A17.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X45_B_HSMB1162_1
(ALLERGEN ARG R 1)		4k3j HEPATOCYTE GROWTH
FACTOR BETA CHAIN
(Homo
sapiens)		3 / 3GLU B 493
HIS B  60
GLU B  75
None
0.74A12.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X45_B_HSMB1162_1
(ALLERGEN ARG R 1)		4qam X-LINKED RETINITIS
PIGMENTOSA GTPASE
REGULATOR-INTERACTIN
G PROTEIN 1
(Homo
sapiens)		3 / 3GLU B1245
HIS B1174
GLU B1121
None
0.83A19.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X45_B_HSMB1162_1
(ALLERGEN ARG R 1)		4uf4 CARBOXYPEPTIDASE A1
(Homo
sapiens)		3 / 3GLU A 380
HIS A 179
GLU A 182
O2V  A1419 (-1.8A)
ZN  A1420 ( 3.1A)
ZN  A1420 (-1.9A)
0.83A15.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X45_B_HSMB1162_1
(ALLERGEN ARG R 1)		4zdl O-PHOSPHOSERYL-TRNA(
SEC) SELENIUM
TRANSFERASE
(Homo
sapiens)		3 / 3GLU A 194
HIS A 368
GLU A 197
None
0.79A13.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X45_B_HSMB1162_1
(ALLERGEN ARG R 1)		5j6s ENDOPLASMIC
RETICULUM
AMINOPEPTIDASE 2
(Homo
sapiens)		3 / 3GLU A 337
HIS A 370
GLU A 371
6GA  A1015 (-4.0A)
ZN  A1001 ( 3.2A)
6GA  A1015 (-3.0A)
0.79A9.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X45_B_HSMB1162_1
(ALLERGEN ARG R 1)		5mrv CARBOXYPEPTIDASE O
(Homo
sapiens)		3 / 3GLU A 290
HIS A  88
GLU A  91
 ZN  A 401 ( 4.6A)
ZN  A 401 (-3.2A)
ZN  A 401 (-1.9A)
0.84A16.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X45_B_HSMB1162_1
(ALLERGEN ARG R 1)		6cet GATOR COMPLEX
PROTEIN DEPDC5
(Homo
sapiens)		3 / 3GLU D1497
HIS D1375
GLU D1350
None
0.77A18.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X45_C_HSMC1160_1
(ALLERGEN ARG R 1)		1lbk GLUTATHIONE
S-TRANSFERASE CLASS
PI CHIMAERA (CODA)
(Homo
sapiens)		4 / 7SER A 149
TYR A 153
TYR A 179
ILE A 143
None
1.18A21.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X45_C_HSMC1160_1
(ALLERGEN ARG R 1)		2crw ADP-RIBOSYLATION
FACTOR
GTPASE-ACTIVATING
PROTEIN 3
(Homo
sapiens)		4 / 7SER A  67
TYR A  47
VAL A  49
ILE A  69
None
1.25A19.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X45_C_HSMC1160_1
(ALLERGEN ARG R 1)		2f4w UBIQUITIN-CONJUGATIN
G ENZYME E2, J2
(Homo
sapiens)		4 / 7SER A 146
TYR A  61
VAL A  47
ILE A 167
None
1.24A24.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X45_C_HSMC1160_1
(ALLERGEN ARG R 1)		2wbi ACYL-COA
DEHYDROGENASE FAMILY
MEMBER 11
(Homo
sapiens)		4 / 7SER A 325
VAL A 376
ILE A 322
TRP A 321
None
1.19A16.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X45_C_HSMC1160_1
(ALLERGEN ARG R 1)		3pdf DIPEPTIDYL PEPTIDASE
1
(Homo
sapiens)		4 / 7TYR A 321
VAL A 431
TYR A 323
ILE A  63
None
None
CL  A 443 (-4.7A)
None
1.12A16.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X45_C_HSMC1160_1
(ALLERGEN ARG R 1)		4qti UROKINASE
PLASMINOGEN
ACTIVATOR SURFACE
RECEPTOR
(Homo
sapiens)		4 / 7VAL U 238
TYR U 236
ILE U 130
ASP U 163
None
1.02A18.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X45_C_HSMC1160_1
(ALLERGEN ARG R 1)		5cxv MUSCARINIC
ACETYLCHOLINE
RECEPTOR
M1,ENDOLYSIN,MUSCARI
NIC ACETYLCHOLINE
RECEPTOR M1
(Escherichia
virus
T4;
Homo
sapiens)		4 / 7SER A  78
TYR A 408
ILE A  73
ASP A 105
None
0HK  A 501 (-4.7A)
None
0HK  A 501 (-3.0A)
1.21A15.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X45_C_HSMC1160_1
(ALLERGEN ARG R 1)		5j68 ASTROTACTIN-2
(Homo
sapiens)		4 / 7SER A1203
TYR A1189
VAL A1185
ILE A1215
None
1.04A14.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X45_C_HSMC1160_1
(ALLERGEN ARG R 1)		5m7r PROTEIN O-GLCNACASE
(Homo
sapiens)		4 / 7SER A 268
VAL A 228
ILE A 271
TRP A 249
None
1.18A9.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X45_C_HSMC1160_1
(ALLERGEN ARG R 1)		5n2d PROGRAMMED CELL
DEATH 1 LIGAND 1
(Homo
sapiens)		4 / 7TYR A  28
VAL A 128
TYR A 112
ILE A 101
None
1.21A15.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X45_C_HSMC1160_1
(ALLERGEN ARG R 1)		5sym ACYL-PROTEIN
THIOESTERASE 1
(Homo
sapiens)		4 / 7VAL A  24
TYR A  51
ILE A  44
ASP A 223
None
1.17A18.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X45_C_HSMC1160_1
(ALLERGEN ARG R 1)		5vvo PROTEIN O-GLCNACASE
(Homo
sapiens)		4 / 7SER A 268
VAL A 228
ILE A 271
TRP A 249
None
1.16A14.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X45_C_HSMC1161_1
(ALLERGEN ARG R 1)		1tnr TUMOR NECROSIS
FACTOR BETA
(Homo
sapiens)		4 / 5VAL A  75
TYR A  73
VAL A  67
ASP A 145
None
1.26A17.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X45_C_HSMC1161_1
(ALLERGEN ARG R 1)		2dmy SPERMATID
PERINUCLEAR
RNA-BINDING PROTEIN
(Homo
sapiens)		4 / 5VAL A  73
TYR A  59
VAL A  54
ASP A  53
None
1.09A18.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X45_C_HSMC1161_1
(ALLERGEN ARG R 1)		2jc6 CALCIUM/CALMODULIN-D
EPENDENT PROTEIN
KINASE TYPE 1D
(Homo
sapiens)		4 / 5VAL A 192
TYR A 198
ASP A 203
SER A 206
None
1.33A17.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X45_C_HSMC1161_1
(ALLERGEN ARG R 1)		2jjd RECEPTOR-TYPE
TYROSINE-PROTEIN
PHOSPHATASE EPSILON
(Homo
sapiens)		4 / 5VAL A 686
TYR A 683
VAL A 658
ASP A 657
None
1.31A14.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X45_C_HSMC1161_1
(ALLERGEN ARG R 1)		2n7g POTASSIUM
VOLTAGE-GATED
CHANNEL SUBFAMILY H
MEMBER 2
(Homo
sapiens)		4 / 5TYR A  70
VAL A  60
ASP A  64
SER A 108
None
1.35A19.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X45_C_HSMC1161_1
(ALLERGEN ARG R 1)		2ozu HISTONE
ACETYLTRANSFERASE
MYST3
(Homo
sapiens)		4 / 5VAL A 617
TYR A 616
ASP A 582
SER A 586
None
1.21A16.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X45_C_HSMC1161_1
(ALLERGEN ARG R 1)		2vc2 INTEGRIN ALPHA-IIB
(Homo
sapiens)		4 / 5VAL A 241
TYR A 253
VAL A 182
SER A 172
None
1.25A14.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X45_C_HSMC1161_1
(ALLERGEN ARG R 1)		3l5h INTERLEUKIN-6
RECEPTOR SUBUNIT
BETA
(Homo
sapiens)		4 / 5TYR A 555
VAL A 548
ASP A 549
SER A 551
None
1.15A12.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X45_C_HSMC1161_1
(ALLERGEN ARG R 1)		3v4p INTEGRIN ALPHA-4
(Homo
sapiens)		4 / 5VAL A 353
TYR A 370
VAL A 306
SER A 276
None
1.21A13.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X45_C_HSMC1161_1
(ALLERGEN ARG R 1)		4d9r COMPLEMENT FACTOR D
(Homo
sapiens)		4 / 5VAL A  45
TYR A  29
VAL A 200
ASP A 137
None
1.10A19.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X45_C_HSMC1161_1
(ALLERGEN ARG R 1)		4gwr PROTEIN
DISULFIDE-ISOMERASE
A6
(Homo
sapiens)		4 / 5VAL A 183
VAL A 174
ASP A 171
SER A 169
None
1.14A21.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X45_C_HSMC1161_1
(ALLERGEN ARG R 1)		4idj FAB HEAVY CHAIN
(Homo
sapiens)		4 / 5VAL H 121
VAL H 150
ASP H 199
SER H 153
None
1.07A22.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X45_C_HSMC1161_1
(ALLERGEN ARG R 1)		4pvg TYROSINE-PROTEIN
PHOSPHATASE
NON-RECEPTOR TYPE 11
(Homo
sapiens)		4 / 5VAL A 518
TYR A 515
VAL A 490
ASP A 489
None
1.25A16.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X45_C_HSMC1161_1
(ALLERGEN ARG R 1)		5ei0 SERPIN A12
(Homo
sapiens)		4 / 5VAL A 249
TYR A 247
VAL A 306
ASP A 305
None
1.09A15.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X45_C_HSMC1161_1
(ALLERGEN ARG R 1)		5ggg PROTEIN
O-LINKED-MANNOSE
BETA-1,2-N-ACETYLGLU
COSAMINYLTRANSFERASE
1
(Homo
sapiens)		4 / 5VAL A 278
TYR A 275
VAL A 347
ASP A 346
None
1.03A15.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X45_C_HSMC1161_1
(ALLERGEN ARG R 1)		5i6v TYROSINE-PROTEIN
PHOSPHATASE
NON-RECEPTOR TYPE 11
(Homo
sapiens)		4 / 5VAL A 518
TYR A 515
VAL A 490
ASP A 489
None
1.22A14.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X45_C_HSMC1161_1
(ALLERGEN ARG R 1)		5lb3 ATP-DEPENDENT DNA
HELICASE Q5
(Homo
sapiens)		4 / 5VAL B 162
TYR B 173
VAL B 156
ASP B 157
None
None
None
MG  B 503 ( 4.0A)
1.10A15.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X45_C_HSMC1161_1
(ALLERGEN ARG R 1)		5lb8 ATP-DEPENDENT DNA
HELICASE Q5
(Homo
sapiens)		4 / 5VAL A 162
TYR A 173
VAL A 156
ASP A 157
None
1.33A15.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X45_C_HSMC1161_1
(ALLERGEN ARG R 1)		5txk UBIQUITIN
CARBOXYL-TERMINAL
HYDROLASE
35,UBIQUITIN
CARBOXYL-TERMINAL
HYDROLASE 35
(Homo
sapiens)		4 / 5VAL A 850
TYR A 866
VAL A 909
ASP A 916
None
0.87A17.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X45_C_HSMC1161_1
(ALLERGEN ARG R 1)		6d4j PROTEIN PATCHED
HOMOLOG 1
(Homo
sapiens)		4 / 5VAL A 477
VAL A 510
ASP A 513
SER A1132
None
1.26A17.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X45_C_HSMC1161_1
(ALLERGEN ARG R 1)		6en4 SPLICING FACTOR 3B
SUBUNIT 3
(Homo
sapiens)		4 / 5VAL A 959
TYR A 970
VAL A 925
SER A 890
None
0.84A17.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X45_C_HSMC1162_1
(ALLERGEN ARG R 1)		1dtd CARBOXYPEPTIDASE A2
(Homo
sapiens)		3 / 3GLU A 626
HIS A 424
GLU A 427
GLU  A 300 (-4.2A)
ZN  A 301 ( 3.4A)
ZN  A 301 (-2.6A)
0.84A18.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X45_C_HSMC1162_1
(ALLERGEN ARG R 1)		1kwm PROCARBOXYPEPTIDASE
B
(Homo
sapiens)		3 / 3GLU A 270
HIS A  69
GLU A  72
None
ZN  A 400 (-3.9A)
ZN  A 400 (-2.1A)
0.87A14.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X45_C_HSMC1162_1
(ALLERGEN ARG R 1)		1zli CARBOXYPEPTIDASE B
(Homo
sapiens)		3 / 3GLU A 270
HIS A  69
GLU A  72
 ZN  A 501 ( 4.8A)
ZN  A 501 (-3.1A)
ZN  A 501 (-2.1A)
0.80A18.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X45_C_HSMC1162_1
(ALLERGEN ARG R 1)		2k2o MYOFERLIN
(Homo
sapiens)		3 / 3GLU A 976
HIS A 927
GLU A 929
None
0.81A26.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X45_C_HSMC1162_1
(ALLERGEN ARG R 1)		2pcu CARBOXYPEPTIDASE A4
(Homo
sapiens)		3 / 3GLU A 270
HIS A  69
GLU A  72
 ZN  A 999 (-4.6A)
ZN  A 999 ( 3.1A)
ZN  A 999 (-2.1A)
0.81A17.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X45_C_HSMC1162_1
(ALLERGEN ARG R 1)		2uzx HEPATOCYTE GROWTH
FACTOR RECEPTOR
(Homo
sapiens)		3 / 3GLU B 493
HIS B  60
GLU B  75
None
0.78A10.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X45_C_HSMC1162_1
(ALLERGEN ARG R 1)		2y1h PUTATIVE
DEOXYRIBONUCLEASE
TATDN3
(Homo
sapiens)		3 / 3GLU A  44
HIS A 147
GLU A 107
PO4  A1275 (-3.2A)
ZN  A1273 ( 3.1A)
ZN  A1274 (-2.4A)
0.79A17.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X45_C_HSMC1162_1
(ALLERGEN ARG R 1)		3al2 DNA TOPOISOMERASE
2-BINDING PROTEIN 1
(Homo
sapiens)		3 / 3GLU A1296
HIS A1285
GLU A1288
None
0.83A21.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X45_C_HSMC1162_1
(ALLERGEN ARG R 1)		3fju CARBOXYPEPTIDASE A1
(Homo
sapiens)		3 / 3GLU A 270
HIS A  69
GLU A  72
ACT  A 515 (-4.3A)
ZN  A 999 ( 3.1A)
ZN  A 999 (-2.1A)
0.77A17.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X45_C_HSMC1162_1
(ALLERGEN ARG R 1)		3lms CARBOXYPEPTIDASE B2
(Homo
sapiens)		3 / 3GLU A 270
HIS A  69
GLU A  72
GLY  A 501 ( 4.6A)
ZN  A 309 ( 3.1A)
ZN  A 309 (-2.0A)
0.74A17.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X45_C_HSMC1162_1
(ALLERGEN ARG R 1)		4k3j HEPATOCYTE GROWTH
FACTOR BETA CHAIN
(Homo
sapiens)		3 / 3GLU B 493
HIS B  60
GLU B  75
None
0.78A12.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X45_C_HSMC1162_1
(ALLERGEN ARG R 1)		4kxb GLUTAMYL
AMINOPEPTIDASE
(Homo
sapiens)		3 / 3GLU A 360
HIS A 393
GLU A 394
BES  A1017 (-2.9A)
ZN  A1001 ( 3.3A)
BES  A1017 (-3.1A)
0.88A10.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X45_C_HSMC1162_1
(ALLERGEN ARG R 1)		4qam X-LINKED RETINITIS
PIGMENTOSA GTPASE
REGULATOR-INTERACTIN
G PROTEIN 1
(Homo
sapiens)		3 / 3GLU B1245
HIS B1174
GLU B1121
None
0.85A19.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X45_C_HSMC1162_1
(ALLERGEN ARG R 1)		4uf4 CARBOXYPEPTIDASE A1
(Homo
sapiens)		3 / 3GLU A 380
HIS A 179
GLU A 182
O2V  A1419 (-1.8A)
ZN  A1420 ( 3.1A)
ZN  A1420 (-1.9A)
0.86A15.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X45_C_HSMC1162_1
(ALLERGEN ARG R 1)		4zdl O-PHOSPHOSERYL-TRNA(
SEC) SELENIUM
TRANSFERASE
(Homo
sapiens)		3 / 3GLU A 194
HIS A 368
GLU A 197
None
0.87A13.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X45_C_HSMC1162_1
(ALLERGEN ARG R 1)		5j6s ENDOPLASMIC
RETICULUM
AMINOPEPTIDASE 2
(Homo
sapiens)		3 / 3GLU A 337
HIS A 370
GLU A 371
6GA  A1015 (-4.0A)
ZN  A1001 ( 3.2A)
6GA  A1015 (-3.0A)
0.79A9.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X45_C_HSMC1162_1
(ALLERGEN ARG R 1)		5mrv CARBOXYPEPTIDASE O
(Homo
sapiens)		3 / 3GLU A 290
HIS A  88
GLU A  91
 ZN  A 401 ( 4.6A)
ZN  A 401 (-3.2A)
ZN  A 401 (-1.9A)
0.86A16.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X45_C_HSMC1162_1
(ALLERGEN ARG R 1)		6cet GATOR COMPLEX
PROTEIN DEPDC5
(Homo
sapiens)		3 / 3GLU D1497
HIS D1375
GLU D1350
None
0.74A18.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X45_C_HSMC1162_1
(ALLERGEN ARG R 1)		6eot DIPEPTIDYL PEPTIDASE
8
(Homo
sapiens)		3 / 3GLU A 376
HIS A 798
GLU A 793
None
0.88A17.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BU1_A_HSMA301_1
(LIPOCALIN)		2wbi ACYL-COA
DEHYDROGENASE FAMILY
MEMBER 11
(Homo
sapiens)		4 / 7SER A 325
VAL A 376
ILE A 322
TRP A 321
None
1.17A16.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BU1_A_HSMA301_1
(LIPOCALIN)		3ehq OSTEOCLAST-STIMULATI
NG FACTOR 1
(Homo
sapiens)		4 / 7SER A  54
TYR A  65
ILE A  39
ASP A  37
None
1.21A19.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BU1_A_HSMA301_1
(LIPOCALIN)		3pdf DIPEPTIDYL PEPTIDASE
1
(Homo
sapiens)		4 / 7TYR A 321
VAL A 431
TYR A 323
ILE A  63
None
None
CL  A 443 (-4.7A)
None
1.07A16.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BU1_A_HSMA301_1
(LIPOCALIN)		4qti UROKINASE
PLASMINOGEN
ACTIVATOR SURFACE
RECEPTOR
(Homo
sapiens)		4 / 7VAL U 238
TYR U 236
ILE U 130
ASP U 163
None
1.10A21.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BU1_A_HSMA301_1
(LIPOCALIN)		5j68 ASTROTACTIN-2
(Homo
sapiens)		4 / 7SER A1203
TYR A1189
VAL A1185
ILE A1215
None
1.14A13.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BU1_A_HSMA301_1
(LIPOCALIN)		5nem INTEGRIN BETA-6
(Homo
sapiens)		4 / 7SER B 337
TYR B 117
ILE B 132
ASP B 128
None
0.83A16.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BU1_A_HSMA301_1
(LIPOCALIN)		5vem ECTONUCLEOTIDE
PYROPHOSPHATASE/PHOS
PHODIESTERASE FAMILY
MEMBER 5
(Homo
sapiens)		4 / 7VAL A  91
TYR A 307
ILE A 317
ASP A 265
None
1.11A15.59
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3RXH_A_HSMA7_1
(CATIONIC TRYPSIN)		1elv COMPLEMENT C1S
COMPONENT
(Homo
sapiens)		5 / 5ASP A 611
SER A 612
SER A 617
VAL A 638
GLY A 648
None
None
SO4  A2001 ( 2.7A)
None
None
0.31A30.24
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3RXH_A_HSMA7_1
(CATIONIC TRYPSIN)		1fxy COAGULATION FACTOR
XA-TRYPSIN CHIMERA
(Homo
sapiens)		5 / 5ASP A 189
SER A 190
SER A 195
VAL A 213
GLY A 226
0G6  A   1 (-2.8A)
0G6  A   1 (-2.8A)
0G6  A   1 (-1.4A)
None
0G6  A   1 (-3.3A)
0.33A55.46
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3RXH_A_HSMA7_1
(CATIONIC TRYPSIN)		1h4w TRYPSIN IVA
(Homo
sapiens)		5 / 5ASP A 189
SER A 190
SER A 195
VAL A 213
GLY A 226
BEN  A 250 (-2.9A)
BEN  A 250 (-2.9A)
BEN  A 250 (-3.6A)
None
BEN  A 250 (-3.3A)
0.24A72.65
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3RXH_A_HSMA7_1
(CATIONIC TRYPSIN)		1o5f SERINE PROTEASE
HEPSIN
(Homo
sapiens)		4 / 5ASP H 189
SER H 195
VAL H 213
GLY H 226
CR9  H 256 (-2.4A)
CR9  H 256 (-1.5A)
CR9  H 256 (-4.3A)
CR9  H 256 (-3.0A)
0.22A41.11
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3RXH_A_HSMA7_1
(CATIONIC TRYPSIN)		1orf GRANZYME A
(Homo
sapiens)		4 / 5ASP A 189
SER A 190
SER A 195
GLY A 226
0G6  A   1 (-2.9A)
0G6  A   1 (-2.9A)
0G6  A   1 (-1.3A)
0G6  A   1 (-3.5A)
0.31A35.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RXH_A_HSMA7_1
(CATIONIC TRYPSIN)		1q3x MANNAN-BINDING
LECTIN SERINE
PROTEASE 2
(Homo
sapiens)		5 / 5ASP A 627
SER A 628
SER A 633
VAL A 653
GLY A 667
 NA  A 800 ( 4.6A)
GOL  A 701 (-3.4A)
GOL  A 701 (-3.0A)
GOL  A 701 (-4.9A)
GOL  A 701 ( 4.0A)
0.35A29.57
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3RXH_A_HSMA7_1
(CATIONIC TRYPSIN)		2ei8 COAGULATION FACTOR
X, HEAVY CHAIN
(Homo
sapiens)		4 / 5ASP A 189
SER A 195
VAL A 213
GLY A 226
DT8  A 700 (-3.5A)
DT8  A 700 ( 3.9A)
DT8  A 700 ( 4.1A)
DT8  A 700 (-3.5A)
0.41A38.98
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3RXH_A_HSMA7_1
(CATIONIC TRYPSIN)		2oq5 TRANSMEMBRANE
PROTEASE, SERINE 11E
(Homo
sapiens)		4 / 5ASP A 189
SER A 195
VAL A 213
GLY A 226
BEN  A 245 (-3.0A)
BEN  A 245 (-3.3A)
None
BEN  A 245 (-3.4A)
0.29A37.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RXH_A_HSMA7_1
(CATIONIC TRYPSIN)		2pks THROMBIN HEAVY CHAIN
FRAGMENT
(Homo
sapiens)		4 / 5ASP C 229
SER C 235
VAL C 255
GLY C 268
G44  C 101 (-2.6A)
G44  C 101 (-3.5A)
None
G44  C 101 (-3.0A)
0.33A21.43
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3RXH_A_HSMA7_1
(CATIONIC TRYPSIN)		2psy KALLIKREIN-5
(Homo
sapiens)		5 / 5ASP A 189
SER A 190
SER A 195
VAL A 213
GLY A 226
None
0.31A47.60
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3RXH_A_HSMA7_1
(CATIONIC TRYPSIN)		2qy0 COMPLEMENT C1R
SUBCOMPONENT
(Homo
sapiens)		4 / 5ASP B 631
SER B 637
VAL B 657
GLY B 668
None
0.57A32.94
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3RXH_A_HSMA7_1
(CATIONIC TRYPSIN)		2r2w PLASMINOGEN
ACTIVATOR, UROKINASE
(Homo
sapiens)		5 / 5ASP U 189
SER U 190
SER U 195
VAL U 213
GLY U 226
4PG  U 300 (-2.8A)
4PG  U 300 (-2.7A)
4PG  U 300 (-3.5A)
None
4PG  U 300 (-3.2A)
0.59A39.36
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3RXH_A_HSMA7_1
(CATIONIC TRYPSIN)		2wpm COAGULATION FACTOR
IXA HEAVY CHAIN
(Homo
sapiens)		4 / 5ASP S 189
SER S 190
SER S 195
GLY S 226
None
0.35A41.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RXH_A_HSMA7_1
(CATIONIC TRYPSIN)		2xyc NEURAL CELL ADHESION
MOLECULE 2
(Homo
sapiens)		4 / 5ASP A 520
SER A 521
SER A 412
VAL A 525
None
1.06A22.18
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3RXH_A_HSMA7_1
(CATIONIC TRYPSIN)		2zec TRYPTASE BETA 2
(Homo
sapiens)		5 / 5ASP A 203
SER A 204
SER A 209
VAL A 227
GLY A 240
11N  A   1 (-2.6A)
11N  A   1 (-3.5A)
11N  A   1 (-3.3A)
None
11N  A   1 (-3.6A)
0.35A40.16
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3RXH_A_HSMA7_1
(CATIONIC TRYPSIN)		3f6u VITAMIN K-DEPENDENT
PROTEIN C HEAVY
CHAIN
(Homo
sapiens)		4 / 5ASP H 189
SER H 195
VAL H 213
GLY H 226
0G6  H   1 (-2.8A)
0G6  H   1 (-1.8A)
None
0G6  H   1 ( 3.9A)
0.45A36.67
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3RXH_A_HSMA7_1
(CATIONIC TRYPSIN)		3gov MASP-1
(Homo
sapiens)		4 / 5ASP B 640
SER B 646
VAL B 666
GLY B 679
None
0.35A35.57
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3RXH_A_HSMA7_1
(CATIONIC TRYPSIN)		3gym PROSTASIN
(Homo
sapiens)		4 / 5ASP A 189
SER A 195
VAL A 213
GLY A 226
None
0.29A40.75
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3RXH_A_HSMA7_1
(CATIONIC TRYPSIN)		3r3g THROMBIN HEAVY CHAIN
(Homo
sapiens)		4 / 5ASP B 189
SER B 195
VAL B 213
GLY B 226
None
0.53A37.55
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3RXH_A_HSMA7_1
(CATIONIC TRYPSIN)		4d9r COMPLEMENT FACTOR D
(Homo
sapiens)		5 / 5ASP A 189
SER A 190
SER A 195
VAL A 213
GLY A 226
None
0.71A37.18
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3RXH_A_HSMA7_1
(CATIONIC TRYPSIN)		4dgj ENTEROPEPTIDASE
CATALYTIC LIGHT
CHAIN
(Homo
sapiens)		4 / 5ASP A 181
SER A 182
SER A 187
GLY A 218
None
0.55A37.13
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3RXH_A_HSMA7_1
(CATIONIC TRYPSIN)		4fxg MANNAN-BINDING
LECTIN SERINE
PROTEASE 2 B CHAIN
(Homo
sapiens)		4 / 5ASP H 627
SER H 628
VAL H 653
GLY H 667
None
0.40A36.18
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3RXH_A_HSMA7_1
(CATIONIC TRYPSIN)		4iw4 MANNAN-BINDING
LECTIN SERINE
PROTEASE 3
(Homo
sapiens)		4 / 5ASP E 639
SER E 645
VAL E 665
GLY E 680
None
0.44A34.80
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3RXH_A_HSMA7_1
(CATIONIC TRYPSIN)		4k8y KALLIKREIN-4
(Homo
sapiens)		5 / 5ASP A 189
SER A 190
SER A 195
VAL A 213
GLY A 226
None
0.50A40.89
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3RXH_A_HSMA7_1
(CATIONIC TRYPSIN)		4r0i SUPPRESSOR OF
TUMORIGENICITY 14
PROTEIN
(Homo
sapiens)		5 / 5ASP A 189
SER A 190
SER A 195
VAL A 213
GLY A 226
3KM  A 900 (-2.9A)
3KM  A 900 (-2.9A)
3KM  A 900 (-3.6A)
None
3KM  A 900 (-3.2A)
0.23A40.16
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3RXH_A_HSMA7_1
(CATIONIC TRYPSIN)		4wwy TRYPSIN-1
(Homo
sapiens)		5 / 5ASP A 189
SER A 190
SER A 195
VAL A 213
GLY A 226
None
0.29A74.44
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3RXH_A_HSMA7_1
(CATIONIC TRYPSIN)		4ylq COAGULATION FACTOR
VII
(Homo
sapiens)		5 / 5ASP H 189
SER H 190
SER H 195
VAL H 213
GLY H 226
0Z7  H 501 (-2.3A)
0Z7  H 501 (-2.3A)
0Z7  H 501 (-1.4A)
0Z7  H 501 ( 4.7A)
0Z7  H 501 (-3.0A)
0.33A40.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RXH_A_HSMA7_1
(CATIONIC TRYPSIN)		5chn ANTIBODY 5M16 FAB
HEAVY CHAIN
(Homo
sapiens)		4 / 5ASP H  85
SER H  88
VAL H 120
GLY H  15
None
1.07A26.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RXH_A_HSMA7_1
(CATIONIC TRYPSIN)		5cjf CARBONIC ANHYDRASE
14
(Homo
sapiens)		4 / 5ASP A 126
SER A 125
SER A  72
VAL A  89
None
1.00A21.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RXH_A_HSMA7_1
(CATIONIC TRYPSIN)		5to3 PROTHROMBIN,THROMBOM
ODULIN
(Homo
sapiens)		4 / 5ASP B 214
SER B 220
VAL B 240
GLY B 253
0G6  B 501 (-2.9A)
0G6  B 501 (-1.3A)
None
0G6  B 501 (-3.6A)
0.32A27.59
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3RXH_A_HSMA7_1
(CATIONIC TRYPSIN)		5ubm COMPLEMENT C1S
SUBCOMPONENT
(Homo
sapiens)		5 / 5ASP A 626
SER A 627
SER A 632
VAL A 653
GLY A 663
None
0.51A34.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RXH_A_HSMA7_1
(CATIONIC TRYPSIN)		6cvz E3 UBIQUITIN-PROTEIN
LIGASE RFWD3
(Homo
sapiens)		4 / 5ASP A 550
SER A 592
VAL A 607
GLY A 605
None
0.92A18.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XMF_A_HSMA202_1
(NITROPHORIN-7)		1suv TRANSFERRIN RECEPTOR
PROTEIN 1
(Homo
sapiens)		3 / 3ASP A 457
LEU A 566
GLY A 567
None
0.50A14.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XMF_A_HSMA202_1
(NITROPHORIN-7)		2ep6 MCTP2 PROTEIN
(Homo
sapiens)		3 / 3ASP A 154
LEU A 126
GLY A 127
None
0.51A23.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XMF_A_HSMA202_1
(NITROPHORIN-7)		2okv PROBABLE
D-TYROSYL-TRNA(TYR)
DEACYLASE 1
(Homo
sapiens)		3 / 3ASP A  37
LEU A  31
GLY A  32
None
0.57A18.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XMF_A_HSMA202_1
(NITROPHORIN-7)		3my0 SERINE/THREONINE-PRO
TEIN KINASE RECEPTOR
R3
(Homo
sapiens)		3 / 3ASP A 235
LEU A 351
GLY A 350
None
0.37A20.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XMF_A_HSMA202_1
(NITROPHORIN-7)		3q4t ACTIVIN RECEPTOR
TYPE-2A
(Homo
sapiens)		3 / 3ASP A 225
LEU A 343
GLY A 342
None
0.55A21.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XMF_A_HSMA202_1
(NITROPHORIN-7)		3qbt INOSITOL
POLYPHOSPHATE
5-PHOSPHATASE OCRL-1
RAS-RELATED PROTEIN
RAB-8A
(Homo
sapiens)		3 / 3ASP A  44
LEU B 661
GLY B 664
SO4  B   1 ( 4.1A)
None
None
0.58A20.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XMF_A_HSMA202_1
(NITROPHORIN-7)		3sei CASKIN-1
(Homo
sapiens)		3 / 3ASP A  32
LEU A  88
GLY A  87
None
0.53A19.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XMF_A_HSMA202_1
(NITROPHORIN-7)		3sen CASKIN-1
(Homo
sapiens)		3 / 3ASP A  35
LEU A  91
GLY A  90
None
0.54A21.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XMF_A_HSMA202_1
(NITROPHORIN-7)		4hxq ARGINASE-1
(Homo
sapiens)		3 / 3ASP A  49
LEU A  97
GLY A  12
None
0.42A20.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XMF_A_HSMA202_1
(NITROPHORIN-7)		4ixu ARGINASE-2,
MITOCHONDRIAL
(Homo
sapiens)		3 / 3ASP A  67
LEU A 116
GLY A  30
None
0.37A19.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XMF_A_HSMA202_1
(NITROPHORIN-7)		4p22 UBIQUITIN-LIKE
MODIFIER-ACTIVATING
ENZYME 1
(Homo
sapiens)		3 / 3ASP A 279
LEU A  54
GLY A  53
None
0.57A18.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XMF_A_HSMA202_1
(NITROPHORIN-7)		4qci ANTI-PDGF-BB
ANTIBODY - LIGHT
CHAIN
(Homo
sapiens)		3 / 3ASP A  50
LEU A  27
GLY A  28
None
0.52A23.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XMF_A_HSMA202_1
(NITROPHORIN-7)		4wq3 CALPAIN SMALL
SUBUNIT 1
(Homo
sapiens)		3 / 3ASP A 154
LEU A 159
GLY A 160
 CA  A 302 (-2.8A)
None
CA  A 302 ( 4.9A)
0.54A23.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XMF_A_HSMA202_1
(NITROPHORIN-7)		4z0x ANTIBODY HC26AM
LIGHT CHAIN VARIABLE
DOMAIN
(Homo
sapiens)		3 / 3ASP A  50
LEU A  27
GLY A  28
None
0.48A20.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XMF_A_HSMA202_1
(NITROPHORIN-7)		5fgc ANTI-HCV E2 FAB
HC33.8 LIGHT CHAIN
(Homo
sapiens)		3 / 3ASP B  50
LEU B  27
GLY B  28
None
0.58A24.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XMF_A_HSMA202_1
(NITROPHORIN-7)		5j13 ANTI-TSLP
FAB-FRAGMENT, LIGHT
CHAIN
(Homo
sapiens)		3 / 3ASP B  53
LEU B  30
GLY B  31
None
0.52A20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XMF_A_HSMA202_1
(NITROPHORIN-7)		5jz8 ASPARTYL/ASPARAGINYL
BETA-HYDROXYLASE
(Homo
sapiens)		3 / 3ASP A 523
LEU A 549
GLY A 550
None
0.50A17.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XMF_A_HSMA202_1
(NITROPHORIN-7)		5tj2 SUGAR ABC
TRANSPORTER
SUBSTRATE-BINDING
PROTEIN,GASDERMIN-B
FUSION PROTEIN
(Escherichia
coli;
Homo
sapiens)		3 / 3ASP A1383
LEU A  75
GLY A  74
None
0.47A16.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DYN_A_HSMA901_0
(EBONY)		4bx9 VACUOLAR PROTEIN
SORTING-ASSOCIATED
PROTEIN 33A
(Homo
sapiens)		4 / 4GLU A  22
VAL A  19
LEU A  15
THR A 181
None
None
None
FMT  A1596 ( 4.0A)
1.37A10.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DYN_A_HSMA901_0
(EBONY)		4i6j F-BOX/LRR-REPEAT
PROTEIN 3
(Homo
sapiens)		4 / 4GLU B 262
VAL B 260
LEU B 295
THR B 267
None
1.30A12.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DYN_A_HSMA901_0
(EBONY)		5lsk PROTEIN MIS12
HOMOLOG
POLYAMINE-MODULATED
FACTOR 1
KINETOCHORE-ASSOCIAT
ED PROTEIN DSN1
HOMOLOG
(Homo
sapiens;
Homo
sapiens;
Homo
sapiens)		4 / 4GLU A 141
VAL B 166
LEU B 167
THR D 270
None
1.29A18.05