POTENTIAL TARGETS FROM HUMAN (RESULTS FROM SUB-STRUCTURAL SIMILARITY SEARCHES)
1) User may click on the DrReposER ID (the second column) to get information on the binding sites and drug molecule.
2) Click View (the second last column) to view matched residues and superposition in the NGL viewer (upper right part).
3) User may also click on the Dock (the last column) to get script for molecular docking in UCSF Chimera through AutoDock Vina.

DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ZOD_A_HQEA1173_1
(FMN-BINDING PROTEIN)		1jy1 TYROSYL-DNA
PHOSPHODIESTERASE
(Homo
sapiens)		4 / 7HIS A 280
ASP A 288
TRP A 289
HIS A 493
None
0.99A19.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ZOD_A_HQEA1173_1
(FMN-BINDING PROTEIN)		1kcw CERULOPLASMIN
(Homo
sapiens)		4 / 7HIS A1020
ASP A 165
HIS A 161
HIS A1028
 CU  A1050 (-3.2A)
None
CU  A1051 (-3.3A)
None
1.50A11.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ZOD_A_HQEA1173_1
(FMN-BINDING PROTEIN)		1p1v SUPEROXIDE DISMUTASE
[CU-ZN]
(Homo
sapiens)		4 / 7HIS A  48
ASP A  83
HIS A 120
HIS A  80
 ZN  A 201 ( 3.2A)
ZN  A 202 (-2.1A)
ZN  A 201 ( 3.2A)
ZN  A 202 (-3.0A)
1.42A21.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ZOD_A_HQEA1173_1
(FMN-BINDING PROTEIN)		1pkr PLASMINOGEN
(Homo
sapiens)		4 / 7TYR A  74
ASP A  57
TRP A  62
ARG A  34
None
1.39A15.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ZOD_A_HQEA1173_1
(FMN-BINDING PROTEIN)		2odt INOSITOL-TETRAKISPHO
SPHATE 1-KINASE
(Homo
sapiens)		4 / 7TYR X 207
ASP X 259
ARG X 124
HIS X 291
None
1.38A21.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ZOD_A_HQEA1173_1
(FMN-BINDING PROTEIN)		4pj3 INTRON-BINDING
PROTEIN AQUARIUS
(Homo
sapiens)		4 / 7HIS A 842
ASP A 872
ARG A 787
HIS A 875
None
1.35A9.03
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4E3H_A_HQEA303_1
(CARBONIC ANHYDRASE 2)		1jd0 CARBONIC ANHYDRASE
XII
(Homo
sapiens)		9 / 10GLN A  92
VAL A 121
LEU A 141
VAL A 143
LEU A 198
THR A 199
THR A 200
VAL A 207
TRP A 209
AZM  A1400 (-3.2A)
AZM  A1400 (-4.6A)
None
AZM  A1400 ( 4.9A)
AZM  A1400 (-3.9A)
AZM  A1400 (-3.6A)
AZM  A1400 (-3.3A)
None
None
0.43A36.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4E3H_A_HQEA303_1
(CARBONIC ANHYDRASE 2)		2b5m DAMAGE-SPECIFIC DNA
BINDING PROTEIN 1
(Homo
sapiens)		5 / 10VAL A 322
LEU A 336
VAL A 334
LEU A 280
VAL A 347
None
1.03A12.58
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4E3H_A_HQEA303_1
(CARBONIC ANHYDRASE 2)		2it4 CARBONIC ANHYDRASE 1
(Homo
sapiens)		7 / 10GLN A  92
LEU A 141
VAL A 143
LEU A 198
THR A 199
VAL A 207
TRP A 209
None
None
PPF  A 500 (-4.9A)
PPF  A 500 (-3.9A)
PPF  A 500 (-3.6A)
None
None
0.58A60.55
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4E3H_A_HQEA303_1
(CARBONIC ANHYDRASE 2)		2it4 CARBONIC ANHYDRASE 1
(Homo
sapiens)		6 / 10PHE A  91
LEU A 141
LEU A 198
THR A 199
VAL A 207
TRP A 209
None
None
PPF  A 500 (-3.9A)
PPF  A 500 (-3.6A)
None
None
1.07A60.55
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4E3H_A_HQEA303_1
(CARBONIC ANHYDRASE 2)		2it4 CARBONIC ANHYDRASE 1
(Homo
sapiens)		5 / 10VAL A 143
PHE A  91
LEU A 141
LEU A 198
THR A 199
PPF  A 500 (-4.9A)
None
None
PPF  A 500 (-3.9A)
PPF  A 500 (-3.6A)
1.02A60.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4E3H_A_HQEA303_1
(CARBONIC ANHYDRASE 2)		2lna AFG3-LIKE PROTEIN 2
(Homo
sapiens)		6 / 10VAL A  44
PHE A  23
LEU A  36
VAL A  38
LEU A  74
VAL A  91
None
1.14A16.17
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4E3H_A_HQEA303_1
(CARBONIC ANHYDRASE 2)		3da2 CARBONIC ANHYDRASE
13
(Homo
sapiens)		5 / 10GLN A  93
PHE A 132
LEU A 142
LEU A 199
VAL A 208
4MD  A 401 (-3.1A)
4MD  A 401 (-4.6A)
None
4MD  A 401 (-4.2A)
None
1.02A60.15
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4E3H_A_HQEA303_1
(CARBONIC ANHYDRASE 2)		3da2 CARBONIC ANHYDRASE
13
(Homo
sapiens)		8 / 10VAL A 122
PHE A 132
LEU A 142
VAL A 144
LEU A 199
THR A 200
VAL A 208
TRP A 210
4MD  A 401 ( 4.6A)
4MD  A 401 (-4.6A)
None
4MD  A 401 ( 4.4A)
4MD  A 401 (-4.2A)
4MD  A 401 (-3.2A)
None
None
0.35A60.15
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4E3H_A_HQEA303_1
(CARBONIC ANHYDRASE 2)		3fe4 CARBONIC ANHYDRASE 6
(Homo
sapiens)		8 / 10GLN A 109
VAL A 140
LEU A 159
VAL A 161
LEU A 219
THR A 220
VAL A 228
TRP A 230
None
0.58A34.81
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4E3H_A_HQEA303_1
(CARBONIC ANHYDRASE 2)		3fe4 CARBONIC ANHYDRASE 6
(Homo
sapiens)		6 / 10LEU A 159
LEU A 219
THR A 220
THR A 221
VAL A 228
TRP A 230
None
0.55A34.81
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4E3H_A_HQEA303_1
(CARBONIC ANHYDRASE 2)		3jxf RECEPTOR-TYPE
TYROSINE-PROTEIN
PHOSPHATASE ZETA
(Homo
sapiens)		5 / 10LEU A 176
LEU A 235
THR A 236
VAL A 244
TRP A 246
None
0.50A30.07
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4E3H_A_HQEA303_1
(CARBONIC ANHYDRASE 2)		3ml5 CARBONIC ANHYDRASE 7
(Homo
sapiens)		6 / 10GLN A  92
VAL A 121
PHE A 131
LEU A 141
LEU A 198
THR A 199
AZM  A 264 (-4.1A)
AZM  A 264 (-4.7A)
AZM  A 264 (-4.4A)
None
AZM  A 264 (-3.4A)
AZM  A 264 (-3.4A)
1.24A55.60
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4E3H_A_HQEA303_1
(CARBONIC ANHYDRASE 2)		3ml5 CARBONIC ANHYDRASE 7
(Homo
sapiens)		10 / 10GLN A  92
VAL A 121
PHE A 131
LEU A 141
VAL A 143
LEU A 198
THR A 199
THR A 200
VAL A 207
TRP A 209
AZM  A 264 (-4.1A)
AZM  A 264 (-4.7A)
AZM  A 264 (-4.4A)
None
AZM  A 264 ( 4.9A)
AZM  A 264 (-3.4A)
AZM  A 264 (-3.4A)
AZM  A 264 (-3.5A)
None
None
0.38A55.60
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4E3H_A_HQEA303_1
(CARBONIC ANHYDRASE 2)		3uyq CARBONIC ANHYDRASE 3
(Homo
sapiens)		7 / 10GLN A  92
VAL A 121
PHE A 130
VAL A 142
THR A 198
THR A 199
TRP A 208
None
None
None
None
ZN  A 261 ( 4.4A)
None
None
0.35A58.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4E3H_A_HQEA303_1
(CARBONIC ANHYDRASE 2)		4i8v CYTOCHROME P450 1A1
(Homo
sapiens)		5 / 10VAL A 407
LEU A  86
VAL A  84
LEU A 396
VAL A  73
None
0.95A21.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4E3H_A_HQEA303_1
(CARBONIC ANHYDRASE 2)		4i8v CYTOCHROME P450 1A1
(Homo
sapiens)		5 / 10VAL A 407
VAL A  84
LEU A 396
THR A 394
VAL A  73
None
1.01A21.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4E3H_A_HQEA303_1
(CARBONIC ANHYDRASE 2)		4j1y COMPLEMENT C1S
SUBCOMPONENT
(Homo
sapiens)		6 / 10VAL A 487
LEU A 464
VAL A 453
LEU A 535
THR A 504
VAL A 470
None
1.20A20.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4E3H_A_HQEA303_1
(CARBONIC ANHYDRASE 2)		4qk3 CARBONIC ANHYDRASE 2
(Homo
sapiens)		6 / 10GLN A  92
VAL A 121
PHE A 131
LEU A 141
LEU A 198
THR A 199
None
None
None
None
None
ZN  A 301 ( 4.4A)
1.22A95.77
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4E3H_A_HQEA303_1
(CARBONIC ANHYDRASE 2)		4qk3 CARBONIC ANHYDRASE 2
(Homo
sapiens)		10 / 10GLN A  92
VAL A 121
PHE A 131
LEU A 141
VAL A 143
LEU A 198
THR A 199
THR A 200
VAL A 207
TRP A 209
None
None
None
None
None
None
ZN  A 301 ( 4.4A)
None
None
None
0.20A95.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4E3H_A_HQEA303_1
(CARBONIC ANHYDRASE 2)		4r7p UTP--GLUCOSE-1-PHOSP
HATE
URIDYLYLTRANSFERASE
(Homo
sapiens)		5 / 10VAL A 460
LEU A 458
LEU A 402
THR A 398
VAL A 430
None
1.00A17.37
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4E3H_A_HQEA303_1
(CARBONIC ANHYDRASE 2)		5cjf CARBONIC ANHYDRASE
14
(Homo
sapiens)		9 / 10GLN A  92
VAL A 121
LEU A 141
VAL A 143
LEU A 198
THR A 199
THR A 200
VAL A 207
TRP A 209
GOL  A 303 (-3.2A)
520  A 302 ( 4.9A)
None
520  A 302 ( 4.9A)
520  A 302 (-3.6A)
520  A 302 (-3.4A)
GOL  A 303 ( 3.5A)
None
None
0.27A36.80
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4E3H_A_HQEA303_1
(CARBONIC ANHYDRASE 2)		5jn9 CARBONIC ANHYDRASE 4
(Homo
sapiens)		8 / 10GLN A  92
VAL A 121
VAL A 143
LEU A 198
THR A 199
THR A 200
VAL A 207
TRP A 209
EZL  A 302 (-4.3A)
EZL  A 302 (-4.7A)
EZL  A 302 ( 4.7A)
EZL  A 302 (-3.5A)
EZL  A 302 (-3.4A)
EZL  A 302 (-3.9A)
None
None
0.35A35.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4E3H_A_HQEA303_1
(CARBONIC ANHYDRASE 2)		5lpe KALLIKREIN-10
(Homo
sapiens)		5 / 10VAL A  67
LEU A  46
VAL A  31
THR A  85
VAL A  52
None
1.06A22.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4E3H_A_HQEA303_1
(CARBONIC ANHYDRASE 2)		5una 7SK SNRNA
METHYLPHOSPHATE
CAPPING ENZYME
(Homo
sapiens)		5 / 10VAL A 447
LEU A 579
VAL A 577
LEU A 437
VAL A 614
None
1.04A23.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4E3H_A_HQEA303_1
(CARBONIC ANHYDRASE 2)		6fe1 CARBONIC ANHYDRASE 9
(Homo
sapiens)		9 / 10GLN A  92
VAL A 121
LEU A 141
VAL A 143
LEU A 198
THR A 199
THR A 200
VAL A 207
TRP A 209
V14  A 302 (-3.8A)
V14  A 302 (-4.7A)
None
None
V14  A 302 (-3.6A)
V14  A 302 (-3.2A)
V14  A 302 (-3.5A)
None
None
0.50A14.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4E3H_A_HQEA303_1
(CARBONIC ANHYDRASE 2)		6fe1 CARBONIC ANHYDRASE 9
(Homo
sapiens)		5 / 10VAL A 143
LEU A 198
THR A 199
THR A 200
VAL A 207
None
V14  A 302 (-3.6A)
V14  A 302 (-3.2A)
V14  A 302 (-3.5A)
None
1.04A14.90
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4QOP_A_HQEA503_1
(CATALASE)		1dgf CATALASE
(Homo
sapiens)		5 / 9ASP A 128
PRO A 129
PHE A 154
LEU A 199
PHE A 200
ACT  A5000 ( 4.9A)
None
None
None
None
0.35A46.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QOP_A_HQEA503_1
(CATALASE)		2pg6 CYTOCHROME P450 2A6
(Homo
sapiens)		5 / 9ILE A 268
ASP A 269
PRO A 264
PHE A 138
ASP A 189
None
1.41A23.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QOP_A_HQEA503_1
(CATALASE)		3j7y BS18A
(Homo
sapiens)		5 / 9PRO r  71
PHE r  92
LEU r  88
TYR r  81
LEU r 107
None
1.24A17.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QOP_A_HQEA503_1
(CATALASE)		4wxu MYOCILIN
(Homo
sapiens)		5 / 9ILE A 465
PHE A 430
LEU A 248
LEU A 486
ASP A 498
None
1.46A20.56
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4QOP_B_HQEB503_1
(CATALASE)		1dgf CATALASE
(Homo
sapiens)		5 / 9ASP A 128
PRO A 129
PHE A 154
LEU A 199
PHE A 200
ACT  A5000 ( 4.9A)
None
None
None
None
0.36A46.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QOP_B_HQEB503_1
(CATALASE)		3j7y BS18A
(Homo
sapiens)		5 / 9PRO r  71
PHE r  92
LEU r  88
TYR r  81
LEU r 107
None
1.23A17.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QOP_B_HQEB503_1
(CATALASE)		4e93 TYROSINE-PROTEIN
KINASE FES/FPS
(Homo
sapiens)		5 / 9ILE A 817
PHE A 754
LEU A 661
LEU A 750
PHE A 746
None
1.41A22.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QOP_B_HQEB503_1
(CATALASE)		4wxu MYOCILIN
(Homo
sapiens)		5 / 9ILE A 465
PHE A 430
LEU A 248
LEU A 486
ASP A 498
None
1.45A20.56
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4QOP_C_HQEC503_1
(CATALASE)		1dgf CATALASE
(Homo
sapiens)		5 / 8ASP A 128
PRO A 129
PHE A 154
LEU A 199
PHE A 200
ACT  A5000 ( 4.9A)
None
None
None
None
0.35A46.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QOP_C_HQEC503_1
(CATALASE)		1y02 FYVE-RING FINGER
PROTEIN SAKURA
(Homo
sapiens)		4 / 8ILE A  93
LEU A  88
TYR A  87
PHE A  71
None
0.90A12.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QOP_C_HQEC503_1
(CATALASE)		2amy PHOSPHOMANNOMUTASE 2
(Homo
sapiens)		4 / 8ILE A 240
PHE A  11
TYR A 205
LEU A  35
None
0.95A20.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QOP_C_HQEC503_1
(CATALASE)		3rc3 ATP-DEPENDENT RNA
HELICASE SUPV3L1,
MITOCHONDRIAL
(Homo
sapiens)		4 / 8ILE A 655
PHE A 593
LEU A 608
PHE A 585
None
0.95A20.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QOP_C_HQEC503_1
(CATALASE)		3zhp CALCIUM-BINDING
PROTEIN 39-LIKE
(Homo
sapiens)		4 / 8ILE A 290
PHE A 277
LEU A 255
LEU A 301
None
0.93A22.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QOP_C_HQEC503_1
(CATALASE)		4nky STEROID
17-ALPHA-HYDROXYLASE
/17,20 LYASE
(Homo
sapiens)		4 / 8PHE A 172
LEU A 195
TYR A 188
PHE A 300
None
0.94A21.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QOP_C_HQEC503_1
(CATALASE)		4tvs TORSIN-1A-INTERACTIN
G PROTEIN 1
(Homo
sapiens)		4 / 8PHE A 492
LEU A 510
LEU A 465
PHE A 469
None
0.86A18.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QOP_C_HQEC503_1
(CATALASE)		4v2d FIBRONECTIN LEUCINE
RICH TRANSMEMBRANE
PROTEIN 2
(Homo
sapiens)		4 / 8ILE A 192
PHE A 200
LEU A 209
PHE A 235
None
0.93A19.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QOP_C_HQEC503_1
(CATALASE)		4wlp NUCLEAR FACTOR
RELATED TO
KAPPA-B-BINDING
PROTEIN
UBIQUITIN
CARBOXYL-TERMINAL
HYDROLASE ISOZYME L5
(Homo
sapiens)		4 / 8PHE A  43
LEU A  52
LEU A  38
PHE B 100
None
0.84A21.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QOP_C_HQEC503_1
(CATALASE)		5e6s INTEGRIN ALPHA-L
INTEGRIN BETA-2
(Homo
sapiens)		4 / 8ILE A 431
LEU B 311
TYR B 308
LEU B 215
None
0.93A19.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QOP_C_HQEC503_1
(CATALASE)		5nvm EUKARYOTIC
TRANSLATION
INITIATION FACTOR 4E
TYPE 2
(Homo
sapiens)		4 / 8ILE A 152
PHE A  88
LEU A 115
LEU A  56
None
0.90A17.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QOP_C_HQEC503_1
(CATALASE)		5yhu MYELIN REGULATORY
FACTOR
(Homo
sapiens)		4 / 8PRO A 405
PHE A 420
LEU A 510
LEU A 417
None
0.89A13.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QOP_C_HQEC503_1
(CATALASE)		5zhu MYELIN REGULATORY
FACTOR
(Homo
sapiens)		4 / 8PRO A 405
PHE A 420
LEU A 510
LEU A 417
None
0.88A9.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QOP_D_HQED503_1
(CATALASE)		3bl9 SCAVENGER
MRNA-DECAPPING
ENZYME DCPS
(Homo
sapiens)		5 / 9PRO A 271
LEU A 166
GLN A 169
LEU A 270
ASP A 325
None
1.23A19.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QOP_D_HQED503_1
(CATALASE)		4ah6 ASPARTATE--TRNA
LIGASE,
MITOCHONDRIAL
(Homo
sapiens)		5 / 9ILE A 543
LEU A 548
GLN A 549
LEU A 486
PHE A 487
None
0.84A21.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QOP_D_HQED503_1
(CATALASE)		4g34 EUKARYOTIC
TRANSLATION
INITIATION FACTOR
2-ALPHA KINASE 3
(Homo
sapiens)		5 / 9ILE A 620
PRO A 594
GLN A 886
TYR A 618
ASP A 614
None
1.47A20.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5FSE_C_HQEC1583_1
(UREASE SUBUNIT ALPHA)		1qf8 CASEIN KINASE II
(Homo
sapiens)		4 / 5ILE A  88
GLN A  96
CYH A  23
GLU A  24
None
1.18A15.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5FSE_C_HQEC1583_1
(UREASE SUBUNIT ALPHA)		1so8 3-HYDROXYACYL-COA
DEHYDROGENASE TYPE
II
(Homo
sapiens)		4 / 5ILE A 189
GLN A 138
ARG A 147
GLU A 135
None
1.33A19.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5FSE_C_HQEC1583_1
(UREASE SUBUNIT ALPHA)		2n12 UNCONVENTIONAL
MYOSIN-VI
(Homo
sapiens)		4 / 5ILE A 106
ARG A 119
CYH A 118
GLU A 121
None
1.43A9.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5FSE_C_HQEC1583_1
(UREASE SUBUNIT ALPHA)		2noz N-GLYCOSYLASE/DNA
LYASE
(Homo
sapiens)		4 / 5ILE A 254
GLN A 135
CYH A 140
GLU A 139
None
0.96A20.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5FSE_C_HQEC1583_1
(UREASE SUBUNIT ALPHA)		2r3v MEVALONATE KINASE
(Homo
sapiens)		4 / 5ILE A 119
GLN A 123
CYH A 161
GLU A 162
None
1.40A23.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5FSE_C_HQEC1583_1
(UREASE SUBUNIT ALPHA)		2y4t DNAJ HOMOLOG
SUBFAMILY C MEMBER 3
(Homo
sapiens)		4 / 5ILE A 174
ARG A 194
CYH A 197
GLU A 196
None
1.08A21.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5FSE_C_HQEC1583_1
(UREASE SUBUNIT ALPHA)		3v6a APOPTOSIS INHIBITOR
5
(Homo
sapiens)		4 / 5ILE A  78
GLN A  47
ARG A  43
GLU A  85
None
1.48A22.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5FSE_C_HQEC1583_1
(UREASE SUBUNIT ALPHA)		4hsu LYSINE-SPECIFIC
HISTONE DEMETHYLASE
1B
(Homo
sapiens)		4 / 5ILE A 335
ARG A 342
CYH A 345
GLU A 348
None
1.42A20.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5FSE_C_HQEC1583_1
(UREASE SUBUNIT ALPHA)		4nh1 CASEIN KINASE II
SUBUNIT BETA
(Homo
sapiens)		4 / 5ILE C  88
GLN C  96
CYH C  23
GLU C  24
None
1.28A15.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5FSE_C_HQEC1583_1
(UREASE SUBUNIT ALPHA)		5ukw GLUCOSE-6-PHOSPHATE
1-DEHYDROGENASE
(Homo
sapiens)		4 / 5ILE A 234
GLN A 372
ARG A 370
CYH A 232
None
1.34A21.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5I3A_A_HQEA303_1
(TYROSINASE)		1kcw CERULOPLASMIN
(Homo
sapiens)		4 / 7HIS A 980
HIS A 103
HIS A 161
ALA A 166
 CU  A1050 (-3.0A)
CU  A1051 (-3.3A)
CU  A1051 (-3.3A)
None
0.72A13.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5I3A_A_HQEA303_1
(TYROSINASE)		1qgr PROTEIN (IMPORTIN
BETA SUBUNIT)
(Homo
sapiens)		4 / 7HIS A 810
ASN A 759
VAL A 815
ALA A 818
None
0.67A15.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5I3A_A_HQEA303_1
(TYROSINASE)		3u9j F-BOX/LRR-REPEAT
PROTEIN 5
(Homo
sapiens)		4 / 7HIS A  80
HIS A 126
HIS A  15
HIS A  57
 FE  A 200 (-3.4A)
FE  A 200 (-3.5A)
FE  A 201 (-3.3A)
FE  A 201 (-3.4A)
0.77A15.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5I3A_A_HQEA303_1
(TYROSINASE)		4qn9 N-ACYL-PHOSPHATIDYLE
THANOLAMINE-HYDROLYZ
ING PHOSPHOLIPASE D
(Homo
sapiens)		4 / 7HIS A 253
HIS A 190
HIS A 343
ALA A 310
 ZN  A 501 ( 3.5A)
ZN  A 502 (-3.5A)
ZN  A 502 ( 3.6A)
3PE  A 503 ( 4.7A)
0.73A22.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5I3A_A_HQEA303_1
(TYROSINASE)		4qn9 N-ACYL-PHOSPHATIDYLE
THANOLAMINE-HYDROLYZ
ING PHOSPHOLIPASE D
(Homo
sapiens)		4 / 7HIS A 343
HIS A 190
HIS A 253
ALA A 310
 ZN  A 502 ( 3.6A)
ZN  A 502 (-3.5A)
ZN  A 501 ( 3.5A)
3PE  A 503 ( 4.7A)
0.88A22.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5I3A_A_HQEA303_1
(TYROSINASE)		5m8t 5,6-DIHYDROXYINDOLE-
2-CARBOXYLIC ACID
OXIDASE
(Homo
sapiens)		6 / 7HIS A 192
HIS A 215
HIS A 377
ASN A 378
HIS A 381
VAL A 391
 ZN  A 512 ( 3.3A)
ZN  A 512 ( 3.3A)
ZN  A 511 ( 3.2A)
0TR  A 513 ( 4.4A)
ZN  A 511 ( 3.3A)
0TR  A 513 (-3.8A)
0.27A25.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5I3A_B_HQEB304_1
(TYROSINASE)		1kcw CERULOPLASMIN
(Homo
sapiens)		4 / 7HIS A 980
HIS A 103
HIS A 161
ALA A 166
 CU  A1050 (-3.0A)
CU  A1051 (-3.3A)
CU  A1051 (-3.3A)
None
0.75A13.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5I3A_B_HQEB304_1
(TYROSINASE)		1qgr PROTEIN (IMPORTIN
BETA SUBUNIT)
(Homo
sapiens)		4 / 7HIS A 810
ASN A 759
VAL A 815
ALA A 818
None
0.71A15.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5I3A_B_HQEB304_1
(TYROSINASE)		3u9j F-BOX/LRR-REPEAT
PROTEIN 5
(Homo
sapiens)		4 / 7HIS A  80
HIS A 126
HIS A  15
HIS A  57
 FE  A 200 (-3.4A)
FE  A 200 (-3.5A)
FE  A 201 (-3.3A)
FE  A 201 (-3.4A)
0.76A15.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5I3A_B_HQEB304_1
(TYROSINASE)		4qn9 N-ACYL-PHOSPHATIDYLE
THANOLAMINE-HYDROLYZ
ING PHOSPHOLIPASE D
(Homo
sapiens)		4 / 7HIS A 253
HIS A 190
HIS A 343
ALA A 310
 ZN  A 501 ( 3.5A)
ZN  A 502 (-3.5A)
ZN  A 502 ( 3.6A)
3PE  A 503 ( 4.7A)
0.73A22.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5I3A_B_HQEB304_1
(TYROSINASE)		4qn9 N-ACYL-PHOSPHATIDYLE
THANOLAMINE-HYDROLYZ
ING PHOSPHOLIPASE D
(Homo
sapiens)		4 / 7HIS A 343
HIS A 190
HIS A 253
ALA A 310
 ZN  A 502 ( 3.6A)
ZN  A 502 (-3.5A)
ZN  A 501 ( 3.5A)
3PE  A 503 ( 4.7A)
0.86A22.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5I3A_B_HQEB304_1
(TYROSINASE)		5m8t 5,6-DIHYDROXYINDOLE-
2-CARBOXYLIC ACID
OXIDASE
(Homo
sapiens)		6 / 7HIS A 192
HIS A 215
HIS A 377
ASN A 378
HIS A 381
VAL A 391
 ZN  A 512 ( 3.3A)
ZN  A 512 ( 3.3A)
ZN  A 511 ( 3.2A)
0TR  A 513 ( 4.4A)
ZN  A 511 ( 3.3A)
0TR  A 513 (-3.8A)
0.33A25.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5I3B_A_HQEA303_1
(TYROSINASE)		1kcw CERULOPLASMIN
(Homo
sapiens)		4 / 7HIS A 980
HIS A 103
HIS A 161
ALA A 166
 CU  A1050 (-3.0A)
CU  A1051 (-3.3A)
CU  A1051 (-3.3A)
None
0.73A13.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5I3B_A_HQEA303_1
(TYROSINASE)		1qgr PROTEIN (IMPORTIN
BETA SUBUNIT)
(Homo
sapiens)		4 / 7HIS A 810
ASN A 759
VAL A 815
ALA A 818
None
0.68A15.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5I3B_A_HQEA303_1
(TYROSINASE)		3u9j F-BOX/LRR-REPEAT
PROTEIN 5
(Homo
sapiens)		4 / 7HIS A  80
HIS A 126
HIS A  15
HIS A  57
 FE  A 200 (-3.4A)
FE  A 200 (-3.5A)
FE  A 201 (-3.3A)
FE  A 201 (-3.4A)
0.78A15.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5I3B_A_HQEA303_1
(TYROSINASE)		4qn9 N-ACYL-PHOSPHATIDYLE
THANOLAMINE-HYDROLYZ
ING PHOSPHOLIPASE D
(Homo
sapiens)		4 / 7HIS A 253
HIS A 190
HIS A 343
ALA A 310
 ZN  A 501 ( 3.5A)
ZN  A 502 (-3.5A)
ZN  A 502 ( 3.6A)
3PE  A 503 ( 4.7A)
0.73A22.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5I3B_A_HQEA303_1
(TYROSINASE)		4qn9 N-ACYL-PHOSPHATIDYLE
THANOLAMINE-HYDROLYZ
ING PHOSPHOLIPASE D
(Homo
sapiens)		4 / 7HIS A 343
HIS A 190
HIS A 253
ALA A 310
 ZN  A 502 ( 3.6A)
ZN  A 502 (-3.5A)
ZN  A 501 ( 3.5A)
3PE  A 503 ( 4.7A)
0.87A22.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5I3B_A_HQEA303_1
(TYROSINASE)		5m8t 5,6-DIHYDROXYINDOLE-
2-CARBOXYLIC ACID
OXIDASE
(Homo
sapiens)		6 / 7HIS A 192
HIS A 215
HIS A 377
ASN A 378
HIS A 381
VAL A 391
 ZN  A 512 ( 3.3A)
ZN  A 512 ( 3.3A)
ZN  A 511 ( 3.2A)
0TR  A 513 ( 4.4A)
ZN  A 511 ( 3.3A)
0TR  A 513 (-3.8A)
0.36A25.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5I3B_B_HQEB303_1
(TYROSINASE)		2y1h PUTATIVE
DEOXYRIBONUCLEASE
TATDN3
(Homo
sapiens)		4 / 5HIS A  14
HIS A  12
HIS A  70
VAL A  42
 ZN  A1274 ( 3.3A)
ZN  A1274 ( 3.2A)
PO4  A1275 (-3.8A)
None
1.20A20.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5I3B_B_HQEB303_1
(TYROSINASE)		3rzu STAM-BINDING PROTEIN
(Homo
sapiens)		4 / 5HIS A 335
HIS A 337
VAL A 366
ALA A 364
 ZN  A   1 (-3.5A)
ZN  A   1 (-3.4A)
None
None
1.23A18.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5I3B_B_HQEB303_1
(TYROSINASE)		3rzv STAM-BINDING PROTEIN
(Homo
sapiens)		4 / 5HIS A 335
HIS A 337
VAL A 366
ALA A 364
 ZN  A   1 (-3.3A)
ZN  A   1 (-3.3A)
None
None
1.23A20.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5I3B_B_HQEB303_1
(TYROSINASE)		5k8d COAGULATION FACTOR
VIII
COAGULATION FACTOR
VIII,IG GAMMA-1
CHAIN C REGION
(Homo
sapiens)		4 / 5HIS B1957
HIS A  99
VAL A 101
ALA B1974
None
1.15A15.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5I3B_B_HQEB303_1
(TYROSINASE)		5m8t 5,6-DIHYDROXYINDOLE-
2-CARBOXYLIC ACID
OXIDASE
(Homo
sapiens)		4 / 5HIS A 192
HIS A 215
HIS A 381
VAL A 391
 ZN  A 512 ( 3.3A)
ZN  A 512 ( 3.3A)
ZN  A 511 ( 3.3A)
0TR  A 513 (-3.8A)
0.39A25.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5I3B_B_HQEB303_1
(TYROSINASE)		5vhi 26S PROTEASOME
NON-ATPASE
REGULATORY SUBUNIT
14
(Homo
sapiens)		4 / 5HIS c 113
HIS c 115
VAL c 144
ALA c 142
None
1.06A20.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5I3B_B_HQEB303_1
(TYROSINASE)		6fe1 CARBONIC ANHYDRASE 9
(Homo
sapiens)		4 / 5HIS A 119
HIS A  96
HIS A 107
ALA A 145
 ZN  A 301 ( 3.1A)
ZN  A 301 ( 3.2A)
None
None
1.18A15.55