POTENTIAL TARGETS FROM HUMAN (RESULTS FROM SUB-STRUCTURAL SIMILARITY SEARCHES)
1) User may click on the DrReposER ID (the second column) to get information on the binding sites and drug molecule.
2) Click View (the second last column) to view matched residues and superposition in the NGL viewer (upper right part).
3) User may also click on the Dock (the last column) to get script for molecular docking in UCSF Chimera through AutoDock Vina.

DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AI8_A_HNQA255_1
(CATHEPSIN B)		1by8 PROTEIN
(PROCATHEPSIN K)
(Homo
sapiens)		4 / 7GLN A 118
GLY A 122
HIS A 261
TRP A 283
None
0.43A23.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AI8_A_HNQA255_1
(CATHEPSIN B)		1cjl PROCATHEPSIN L
(Homo
sapiens)		4 / 7GLN A  19
GLY A  23
HIS A 163
TRP A 189
None
0.35A26.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AI8_A_HNQA255_1
(CATHEPSIN B)		1deu PROCATHEPSIN X
(Homo
sapiens)		4 / 7GLN A  22
GLY A  29
HIS A 180
TRP A 202
None
0.31A27.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AI8_A_HNQA255_1
(CATHEPSIN B)		1ef7 CATHEPSIN X
(Homo
sapiens)		4 / 7GLN A  22
GLY A  29
HIS A 180
TRP A 202
None
0.46A29.45
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3AI8_A_HNQA255_1
(CATHEPSIN B)		1fh0 CATHEPSIN V
(Homo
sapiens)		4 / 7GLN A  19
GLY A  23
HIS A 163
TRP A 189
0IW  A1280 (-2.9A)
0IW  A1280 (-3.6A)
0IW  A1280 (-4.0A)
0IW  A1280 (-4.0A)
0.43A31.82
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3AI8_A_HNQA255_1
(CATHEPSIN B)		1glo CATHEPSIN S
(Homo
sapiens)		4 / 7GLN A  19
GLY A  23
HIS A 164
TRP A 186
None
0.35A32.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AI8_A_HNQA255_1
(CATHEPSIN B)		1m6d CATHEPSIN F
(Homo
sapiens)		4 / 7GLN A  19
GLY A  23
HIS A 159
TRP A 177
MYP  A1280 (-3.2A)
MYP  A1280 (-3.5A)
MYP  A1280 (-3.6A)
MYP  A1280 (-3.8A)
0.47A28.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AI8_A_HNQA255_1
(CATHEPSIN B)		1zcm CALPAIN 1, LARGE
[CATALYTIC] SUBUNIT
(Homo
sapiens)		4 / 7GLN A 109
GLY A 113
HIS A 272
TRP A 298
C1N  A1115 (-3.4A)
C1N  A1115 (-3.1A)
C1N  A1115 (-4.2A)
None
0.51A22.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AI8_A_HNQA255_1
(CATHEPSIN B)		2c0y PROCATHEPSIN S
(Homo
sapiens)		4 / 7GLN A 118
GLY A 122
HIS A 263
TRP A 285
None
0.48A27.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AI8_A_HNQA255_1
(CATHEPSIN B)		2cb5 PROTEIN (BLEOMYCIN
HYDROLASE)
(Homo
sapiens)		4 / 7GLN A  67
GLY A  71
HIS A 372
TRP A 398
None
0.41A22.17
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3AI8_A_HNQA255_1
(CATHEPSIN B)		2ipp CATHEPSIN B
(Homo
sapiens)		6 / 7GLN A  23
GLY A  27
HIS B 110
HIS B 111
HIS B 199
TRP B 221
PYS  A 255 ( 4.7A)
PYS  A 255 (-3.3A)
None
None
None
None
0.45A95.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AI8_A_HNQA255_1
(CATHEPSIN B)		2nqa CALPAIN 8
(Homo
sapiens)		4 / 7GLN A  99
GLY A 103
HIS A 262
TRP A 288
None
0.52A22.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AI8_A_HNQA255_1
(CATHEPSIN B)		2p0r CALPAIN-9
(Homo
sapiens)		4 / 7GLN A  91
GLY A  95
HIS A 254
TRP A 280
None
0.44A21.57
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3AI8_A_HNQA255_1
(CATHEPSIN B)		2pbh PROCATHEPSIN B
(Homo
sapiens)		4 / 7GLN A  23
GLY A  27
HIS A 199
TRP A 221
None
0.43A100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AI8_A_HNQA255_1
(CATHEPSIN B)		2pny ISOPENTENYL-DIPHOSPH
ATE DELTA-ISOMERASE
2
(Homo
sapiens)		4 / 7GLY A 145
HIS A 136
HIS A 135
HIS A  51
None
None
GOL  A 233 (-3.7A)
MN  A 229 (-3.3A)
0.97A19.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AI8_A_HNQA255_1
(CATHEPSIN B)		2vhs CATHSILICATEIN
(Homo
sapiens)		4 / 7GLN A  19
GLY A  23
HIS A 163
TRP A 189
SO4  A1221 (-3.2A)
SO4  A1221 (-3.5A)
SO4  A1221 (-3.8A)
None
0.38A29.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AI8_A_HNQA255_1
(CATHEPSIN B)		3hwn CATHEPSIN L1
(Homo
sapiens)		4 / 7GLN A  19
GLY A  23
HIS A 163
TRP A 189
BD3  A 221 (-3.4A)
BD3  A 221 ( 3.9A)
BD3  A 221 (-4.6A)
None
0.32A27.87
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3AI8_A_HNQA255_1
(CATHEPSIN B)		3k9m CATHEPSIN B
(Homo
sapiens)		4 / 7GLN A  23
GLY A  27
HIS A 199
TRP A 221
None
0.58A99.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AI8_A_HNQA255_1
(CATHEPSIN B)		3ovz CATHEPSIN K
(Homo
sapiens)		4 / 7GLN A  19
GLY A  23
HIS A 162
TRP A 184
O96  A   1 (-3.0A)
O96  A   1 (-3.0A)
O96  A   1 (-3.4A)
None
0.49A28.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AI8_A_HNQA255_1
(CATHEPSIN B)		3pdf DIPEPTIDYL PEPTIDASE
1
(Homo
sapiens)		4 / 7GLN A 228
GLY A 232
HIS A 381
TRP A 405
LXV  A 442 (-3.4A)
LXV  A 442 (-3.5A)
None
None
0.51A24.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AI8_A_HNQA255_1
(CATHEPSIN B)		4miv N-SULPHOGLUCOSAMINE
SULPHOHYDROLASE
(Homo
sapiens)		4 / 7GLN A  93
HIS A  96
HIS A 368
HIS A 125
None
None
FGP  A  70 ( 4.4A)
FGP  A  70 ( 3.7A)
1.20A18.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AI8_A_HNQA255_1
(CATHEPSIN B)		5hxb PROTEIN CEREBLON
(Homo
sapiens)		4 / 7GLN Z 100
GLY Z 354
HIS Z  57
HIS Z 378
None
None
None
85C  Z 502 (-3.8A)
0.87A18.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AI8_A_HNQA255_1
(CATHEPSIN B)		5i4h CATHEPSIN L1
(Homo
sapiens)		4 / 7GLN A  19
GLY A  23
HIS B 163
TRP B 189
None
0.37A18.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AI8_A_HNQA255_1
(CATHEPSIN B)		6bdt CALPAIN-3
(Homo
sapiens)		4 / 7GLN A 123
GLY A 127
HIS A 334
TRP A 360
None
0.47A15.42
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3AI8_B_HNQB255_1
(CATHEPSIN B)		2ipp CATHEPSIN B
(Homo
sapiens)		5 / 6GLN A  23
GLY A  27
HIS B 110
HIS B 111
TRP B 221
PYS  A 255 ( 4.7A)
PYS  A 255 (-3.3A)
None
None
None
0.34A95.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AI8_B_HNQB255_1
(CATHEPSIN B)		2xzo REGULATOR OF
NONSENSE TRANSCRIPTS
1
(Homo
sapiens)		4 / 6GLN A 491
GLY A 492
HIS A 663
CYH A 664
None
1.49A17.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AI8_B_HNQB255_1
(CATHEPSIN B)		4o2w E3 UBIQUITIN-PROTEIN
LIGASE HERC1
(Homo
sapiens)		4 / 6GLN A4009
GLY A4052
HIS A4354
CYH A4034
None
1.21A21.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AI8_B_HNQB255_1
(CATHEPSIN B)		5k5l TRANSCRIPTIONAL
REPRESSOR CTCF
(Homo
sapiens)		4 / 6GLY E 453
HIS E 460
HIS E 441
CYH E 439
None
ZN  E 501 (-3.1A)
None
ZN  E 501 (-2.3A)
1.48A13.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Y1Y_A_HNQA201_1
(BROMODOMAIN-CONTAINI
NG PROTEIN 4)		1t0p INTEGRIN ALPHA-L
(Homo
sapiens)		4 / 8VAL A 157
LEU A 295
LEU A 298
TYR A 166
None
0.92A21.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Y1Y_A_HNQA201_1
(BROMODOMAIN-CONTAINI
NG PROTEIN 4)		1xnt PROTEIN (DNA-REPAIR
PROTEIN XRCC1)
(Homo
sapiens)		4 / 8VAL A 128
LEU A  47
LEU A   6
ILE A  60
None
0.91A18.48
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5Y1Y_A_HNQA201_1
(BROMODOMAIN-CONTAINI
NG PROTEIN 4)		2dvr BROMODOMAIN-CONTAINI
NG PROTEIN 2
(Homo
sapiens)		8 / 8PRO A  32
VAL A  37
LEU A  42
LEU A  44
CYH A  86
TYR A  89
ASN A  90
ILE A  96
None
0.38A65.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Y1Y_A_HNQA201_1
(BROMODOMAIN-CONTAINI
NG PROTEIN 4)		2f6n BROMODOMAIN PHD
FINGER TRANSCRIPTION
FACTOR
(Homo
sapiens)		4 / 8VAL A  97
CYH A 144
TYR A 147
ASN A 148
None
0.50A26.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Y1Y_A_HNQA201_1
(BROMODOMAIN-CONTAINI
NG PROTEIN 4)		2h00 METHYLTRANSFERASE 10
DOMAIN CONTAINING
PROTEIN
(Homo
sapiens)		4 / 8VAL A  42
LEU A  83
CYH A  20
ILE A  31
None
0.88A20.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Y1Y_A_HNQA201_1
(BROMODOMAIN-CONTAINI
NG PROTEIN 4)		2mbg RALA-BINDING PROTEIN
1
(Homo
sapiens)		4 / 8VAL A 350
LEU A 278
LEU A 279
ILE A 322
None
0.77A19.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Y1Y_A_HNQA201_1
(BROMODOMAIN-CONTAINI
NG PROTEIN 4)		2xwb COMPLEMENT C3B
ALPHA' CHAIN
(Homo
sapiens)		4 / 8VAL B 817
LEU B 907
LEU B 813
ILE B 878
None
0.92A9.52
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5Y1Y_A_HNQA201_1
(BROMODOMAIN-CONTAINI
NG PROTEIN 4)		2yek BROMODOMAIN-CONTAINI
NG PROTEIN 2
(Homo
sapiens)		7 / 8PRO A  98
VAL A 103
LEU A 108
CYH A 152
TYR A 155
ASN A 156
ILE A 162
EAM  A1188 (-4.6A)
EAM  A1188 (-4.4A)
EAM  A1188 ( 3.8A)
EAM  A1188 ( 4.3A)
None
EAM  A1188 (-3.2A)
EAM  A1188 (-3.8A)
0.42A68.61
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5Y1Y_A_HNQA201_1
(BROMODOMAIN-CONTAINI
NG PROTEIN 4)		2yek BROMODOMAIN-CONTAINI
NG PROTEIN 2
(Homo
sapiens)		7 / 8PRO A  98
VAL A 103
LEU A 108
LEU A 110
CYH A 152
TYR A 155
ASN A 156
EAM  A1188 (-4.6A)
EAM  A1188 (-4.4A)
EAM  A1188 ( 3.8A)
EAM  A1188 (-4.5A)
EAM  A1188 ( 4.3A)
None
EAM  A1188 (-3.2A)
0.40A68.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Y1Y_A_HNQA201_1
(BROMODOMAIN-CONTAINI
NG PROTEIN 4)		3ctz XAA-PRO
AMINOPEPTIDASE 1
(Homo
sapiens)		4 / 8VAL A 247
LEU A 251
LEU A 253
ILE A 237
None
0.76A11.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Y1Y_A_HNQA201_1
(BROMODOMAIN-CONTAINI
NG PROTEIN 4)		3k2j PROTEIN POLYBROMO-1
(Homo
sapiens)		4 / 8PRO A 375
TYR A 430
ASN A 431
ILE A 437
 CL  A   2 ( 4.2A)
None
None
None
0.50A26.32
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5Y1Y_A_HNQA201_1
(BROMODOMAIN-CONTAINI
NG PROTEIN 4)		3nxb CAT EYE SYNDROME
CRITICAL REGION
PROTEIN 2
(Homo
sapiens)		5 / 8PRO A 458
VAL A 463
CYH A 510
TYR A 513
ASN A 514
None
EDO  A   1 (-4.3A)
EDO  A   1 ( 3.9A)
None
EDO  A   1 (-3.3A)
0.58A32.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Y1Y_A_HNQA201_1
(BROMODOMAIN-CONTAINI
NG PROTEIN 4)		3pkj NAD-DEPENDENT
DEACETYLASE
SIRTUIN-6
(Homo
sapiens)		4 / 8PRO A 290
VAL A 102
LEU A 104
LEU A  99
None
0.86A18.42
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5Y1Y_A_HNQA201_1
(BROMODOMAIN-CONTAINI
NG PROTEIN 4)		3q2e BROMODOMAIN AND WD
REPEAT-CONTAINING
PROTEIN 1
(Homo
sapiens)		4 / 8PRO A1337
VAL A1342
TYR A1392
ILE A1400
None
None
ACT  A   1 ( 4.9A)
None
0.66A30.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Y1Y_A_HNQA201_1
(BROMODOMAIN-CONTAINI
NG PROTEIN 4)		4cri TUMOR SUPPRESSOR
P53-BINDING PROTEIN
1
(Homo
sapiens)		4 / 8VAL A1491
LEU A1534
LEU A1602
TYR A1515
None
0.92A22.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5Y1Y_A_HNQA201_1
(BROMODOMAIN-CONTAINI
NG PROTEIN 4)		4hbx BROMODOMAIN-CONTAINI
NG PROTEIN 4
(Homo
sapiens)		8 / 8PRO A  82
VAL A  87
LEU A  92
LEU A  94
CYH A 136
TYR A 139
ASN A 140
ILE A 146
14X  A 201 (-4.4A)
14X  A 201 (-4.7A)
14X  A 201 (-4.4A)
None
14X  A 201 ( 3.9A)
None
14X  A 201 (-3.1A)
14X  A 201 ( 4.0A)
0.39A100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Y1Y_A_HNQA201_1
(BROMODOMAIN-CONTAINI
NG PROTEIN 4)		4n3w CREB-BINDING PROTEIN
(Homo
sapiens)		4 / 8PRO A1110
VAL A1115
LEU A1120
TYR A1167
None
0.42A20.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Y1Y_A_HNQA201_1
(BROMODOMAIN-CONTAINI
NG PROTEIN 4)		4n3w CREB-BINDING PROTEIN
(Homo
sapiens)		4 / 8VAL A1115
LEU A1120
TYR A1167
ASN A1168
None
0.46A20.42
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5Y1Y_A_HNQA201_1
(BROMODOMAIN-CONTAINI
NG PROTEIN 4)		4uyd BROMODOMAIN-CONTAINI
NG PROTEIN 4
(Homo
sapiens)		8 / 8PRO A  82
VAL A  87
LEU A  92
LEU A  94
CYH A 136
TYR A 139
ASN A 140
ILE A 146
V1T  A1171 (-4.2A)
V1T  A1171 (-4.9A)
V1T  A1171 (-3.8A)
None
V1T  A1171 ( 4.4A)
None
V1T  A1171 (-3.1A)
DMS  A1169 ( 4.3A)
0.28A100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5Y1Y_A_HNQA201_1
(BROMODOMAIN-CONTAINI
NG PROTEIN 4)		4uyg BROMODOMAIN-CONTAINI
NG PROTEIN 2
(Homo
sapiens)		7 / 8PRO A 371
VAL A 376
LEU A 381
LEU A 383
CYH A 425
TYR A 428
ASN A 429
None
73B  A1456 (-4.0A)
73B  A1456 (-4.9A)
73B  A1456 (-4.9A)
73B  A1456 (-3.3A)
None
73B  A1456 (-3.3A)
0.48A35.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Y1Y_A_HNQA201_1
(BROMODOMAIN-CONTAINI
NG PROTEIN 4)		4ykn PHOSPHATIDYLINOSITOL
3-KINASE REGULATORY
SUBUNIT
ALPHA,PHOSPHATIDYLIN
OSITOL
4,5-BISPHOSPHATE
3-KINASE CATALYTIC
SUBUNIT ALPHA
ISOFORM FUSION
PROTEIN
(Homo
sapiens)		4 / 8LEU A1092
LEU A1094
CYH A1036
ILE A1045
None
0.90A6.68
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5Y1Y_A_HNQA201_1
(BROMODOMAIN-CONTAINI
NG PROTEIN 4)		4z93 BROMODOMAIN-CONTAINI
NG PROTEIN 4
(Homo
sapiens)		7 / 8PRO A 375
VAL A 380
LEU A 385
LEU A 387
CYH A 429
TYR A 432
ASN A 433
4LD  A 501 (-3.9A)
4LD  A 501 ( 3.8A)
4LD  A 501 (-4.1A)
4LD  A 501 (-4.4A)
4LD  A 501 (-3.4A)
4LD  A 501 ( 3.9A)
4LD  A 501 (-2.8A)
0.40A38.89
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5Y1Y_A_HNQA201_1
(BROMODOMAIN-CONTAINI
NG PROTEIN 4)		5cqa BROMODOMAIN ADJACENT
TO ZINC FINGER
DOMAIN PROTEIN 2B
(Homo
sapiens)		4 / 8VAL A1893
CYH A1940
ASN A1944
ILE A1950
2LY  A2001 ( 4.8A)
2LY  A2001 ( 4.3A)
2LY  A2001 (-3.2A)
2LY  A2001 ( 4.5A)
0.55A31.45
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5Y1Y_A_HNQA201_1
(BROMODOMAIN-CONTAINI
NG PROTEIN 4)		5fg6 BROMODOMAIN-CONTAINI
NG PROTEIN 1
(Homo
sapiens)		4 / 8VAL A 591
CYH A 638
TYR A 641
ASN A 642
5XE  A 705 (-3.9A)
5XE  A 705 (-3.6A)
5XE  A 705 (-4.8A)
5XE  A 705 (-3.3A)
0.36A32.61
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5Y1Y_A_HNQA201_1
(BROMODOMAIN-CONTAINI
NG PROTEIN 4)		5h6y NUCLEOSOME-REMODELIN
G FACTOR SUBUNIT
BPTF
(Homo
sapiens)		4 / 8PRO A  92
VAL A  97
CYH A 144
TYR A 147
None
0.65A35.20
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5Y1Y_A_HNQA201_1
(BROMODOMAIN-CONTAINI
NG PROTEIN 4)		5h6y NUCLEOSOME-REMODELIN
G FACTOR SUBUNIT
BPTF
(Homo
sapiens)		4 / 8VAL A  97
CYH A 144
TYR A 147
ASN A 148
None
0.38A35.20
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5Y1Y_A_HNQA201_1
(BROMODOMAIN-CONTAINI
NG PROTEIN 4)		5hjc BROMODOMAIN-CONTAINI
NG PROTEIN 3
(Homo
sapiens)		7 / 8PRO A 333
VAL A 338
LEU A 343
LEU A 345
CYH A 387
TYR A 390
ASN A 391
None
0.53A39.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Y1Y_A_HNQA201_1
(BROMODOMAIN-CONTAINI
NG PROTEIN 4)		5i8g CREB-BINDING PROTEIN
(Homo
sapiens)		4 / 8PRO A1110
VAL A1115
LEU A1120
TYR A1167
69E  A1404 (-3.7A)
69E  A1404 (-4.3A)
69E  A1404 (-4.2A)
69E  A1404 (-4.8A)
0.60A22.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Y1Y_A_HNQA201_1
(BROMODOMAIN-CONTAINI
NG PROTEIN 4)		5i8g CREB-BINDING PROTEIN
(Homo
sapiens)		4 / 8VAL A1115
LEU A1120
TYR A1167
ASN A1168
69E  A1404 (-4.3A)
69E  A1404 (-4.2A)
69E  A1404 (-4.8A)
69E  A1404 (-3.0A)
0.23A22.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Y1Y_A_HNQA201_1
(BROMODOMAIN-CONTAINI
NG PROTEIN 4)		5lkz HISTONE
ACETYLTRANSFERASE
P300,HISTONE
ACETYLTRANSFERASE
P300
(Homo
sapiens)		5 / 8PRO A1074
VAL A1079
LEU A1084
TYR A1131
ASN A1132
None
0.68A12.77
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5Y1Y_A_HNQA201_1
(BROMODOMAIN-CONTAINI
NG PROTEIN 4)		5lpk HISTONE
ACETYLTRANSFERASE
P300
(Homo
sapiens)		5 / 8PRO A1074
VAL A1079
LEU A1084
TYR A1131
ASN A1132
XDM  A1201 (-3.9A)
XDM  A1201 (-4.7A)
XDM  A1201 ( 4.4A)
XDM  A1201 (-4.4A)
XDM  A1201 (-3.1A)
0.61A31.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Y1Y_A_HNQA201_1
(BROMODOMAIN-CONTAINI
NG PROTEIN 4)		5mg2 TRANSCRIPTION
INITIATION FACTOR
TFIID SUBUNIT 1
(Homo
sapiens)		4 / 8PRO A1527
VAL A1532
TYR A1582
ASN A1583
7M8  A1704 (-3.8A)
7M8  A1704 (-3.5A)
7M8  A1704 ( 4.7A)
7M8  A1704 (-3.1A)
0.52A29.10
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5Y1Y_A_HNQA201_1
(BROMODOMAIN-CONTAINI
NG PROTEIN 4)		5o5a PEREGRIN
(Homo
sapiens)		4 / 8VAL A 657
CYH A 704
TYR A 707
ASN A 708
9LN  A 802 ( 4.1A)
9LN  A 802 (-3.4A)
9LN  A 802 ( 4.7A)
9LN  A 802 (-3.2A)
0.29A31.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Y1Y_A_HNQA201_1
(BROMODOMAIN-CONTAINI
NG PROTEIN 4)		5pfr BROMODOMAIN ADJACENT
TO ZINC FINGER
DOMAIN PROTEIN 2B
(Homo
sapiens)		4 / 8VAL A1893
CYH A1940
ASN A1944
ILE A1950
None
None
EDO  A2001 (-3.2A)
EDO  A2001 ( 4.6A)
0.57A29.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Y1Y_A_HNQA201_1
(BROMODOMAIN-CONTAINI
NG PROTEIN 4)		5pq9 BROMODOMAIN-CONTAINI
NG PROTEIN 1
(Homo
sapiens)		4 / 8VAL A  59
CYH A 106
TYR A 109
ASN A 110
EDO  A 202 (-4.5A)
EDO  A 202 (-3.4A)
EDO  A 201 (-4.7A)
EDO  A 201 (-3.2A)
0.39A28.75
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5Y1Y_A_HNQA201_1
(BROMODOMAIN-CONTAINI
NG PROTEIN 4)		5u6v BROMODOMAIN-CONTAINI
NG PROTEIN 2
(Homo
sapiens)		7 / 8PRO A 371
VAL A 376
LEU A 381
LEU A 383
CYH A 425
TYR A 428
ASN A 429
7WY  A 501 (-4.4A)
7WY  A 501 ( 4.5A)
7WY  A 501 (-4.9A)
None
7WY  A 501 ( 3.8A)
None
7WY  A 501 (-3.4A)
0.39A41.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Y1Y_A_HNQA201_1
(BROMODOMAIN-CONTAINI
NG PROTEIN 4)		5uiy BROMODOMAIN ADJACENT
TO ZINC FINGER
DOMAIN PROTEIN 1A
(Homo
sapiens)		4 / 8VAL A1458
CYH A1505
TYR A1508
ASN A1509
None
0.58A28.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Y1Y_A_HNQA201_1
(BROMODOMAIN-CONTAINI
NG PROTEIN 4)		5v84 CAT EYE SYNDROME
CRITICAL REGION
PROTEIN 2
(Homo
sapiens)		5 / 8PRO A 458
VAL A 463
CYH A 510
TYR A 513
ASN A 514
96V  A 602 (-4.5A)
96V  A 602 (-3.9A)
96V  A 602 ( 3.9A)
96V  A 602 ( 4.3A)
96V  A 602 (-2.6A)
0.43A28.87
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5Y1Y_A_HNQA201_1
(BROMODOMAIN-CONTAINI
NG PROTEIN 4)		5vbr BROMODOMAIN
TESTIS-SPECIFIC
PROTEIN
(Homo
sapiens)		8 / 8PRO A  51
VAL A  56
LEU A  61
LEU A  63
CYH A 105
TYR A 108
ASN A 109
ILE A 115
IBI  A 201 (-4.3A)
IBI  A 201 ( 4.6A)
IBI  A 201 (-4.2A)
IBI  A 201 (-4.9A)
IBI  A 201 ( 4.0A)
IBI  A 201 ( 4.5A)
IBI  A 201 (-3.3A)
IBI  A 201 ( 3.8A)
0.56A64.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Y1Y_A_HNQA201_1
(BROMODOMAIN-CONTAINI
NG PROTEIN 4)		5w0e CREB-BINDING PROTEIN
(Homo
sapiens)		4 / 8PRO A1110
VAL A1115
LEU A1120
TYR A1167
9U4  A1201 (-3.9A)
9U4  A1201 (-4.6A)
9U4  A1201 ( 4.1A)
None
0.60A20.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Y1Y_A_HNQA201_1
(BROMODOMAIN-CONTAINI
NG PROTEIN 4)		5w0e CREB-BINDING PROTEIN
(Homo
sapiens)		4 / 8VAL A1115
LEU A1120
TYR A1167
ASN A1168
9U4  A1201 (-4.6A)
9U4  A1201 ( 4.1A)
None
9U4  A1201 (-3.2A)
0.40A20.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Y1Y_A_HNQA201_1
(BROMODOMAIN-CONTAINI
NG PROTEIN 4)		5y1z PROTEIN KINASE
C-BINDING PROTEIN 1
(Homo
sapiens)		4 / 8VAL C 177
CYH C 224
TYR C 227
ASN C 228
None
0.53A16.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Y1Y_A_HNQA201_1
(BROMODOMAIN-CONTAINI
NG PROTEIN 4)		6dne BROMODOMAIN-CONTAINI
NG PROTEIN 4
(Homo
sapiens)		8 / 8PRO A  82
VAL A  87
LEU A  92
LEU A  94
CYH A 136
TYR A 139
ASN A 140
ILE A 146
H1V  A 501 (-4.6A)
H1V  A 501 ( 4.4A)
H1V  A 501 (-4.2A)
H1V  A 501 (-4.7A)
H1V  A 501 ( 4.2A)
None
H1V  A 501 (-3.2A)
H1V  A 501 (-3.8A)
0.46Aundetectable