POTENTIAL TARGETS FROM HUMAN (RESULTS FROM SUB-STRUCTURAL SIMILARITY SEARCHES)1) User may click on the DrReposER ID (the second column) to get information on the binding sites and drug molecule.
2) Click View (the second last column) to view matched residues and superposition in the NGL viewer (upper right part).
3) User may also click on the Dock (the last column) to get script for molecular docking in UCSF Chimera through AutoDock Vina.

	DrReposER ID / Desc.	Hit PDBID	Hit Macromolecule	Res. Matches	Interface	HETATM	RMSD	Seq. Identity (%)	View	Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4HVC_A_HFGA1602_0 (BIFUNCTIONAL GLUTAMATE/PROLINE--T RNA LIGASE)	2jjd	RECEPTOR-TYPE TYROSINE-PROTEIN PHOSPHATASE EPSILON (Homo sapiens)	5 / 12	HIS A 591 GLU A 530 VAL A 528 THR A 639 GLY A 638	None	1.02A	21.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4HVC_A_HFGA1602_0 (BIFUNCTIONAL GLUTAMATE/PROLINE--T RNA LIGASE)	2ppl	PANCREATIC LIPASE-RELATED PROTEIN 1 (Homo sapiens)	5 / 12	GLU A 179 VAL A 142 PRO A  46 THR A  37 GLY A  36	None	1.45A	21.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4HVC_A_HFGA1602_0 (BIFUNCTIONAL GLUTAMATE/PROLINE--T RNA LIGASE)	2pvs	PANCREATIC LIPASE-RELATED PROTEIN 2 (Homo sapiens)	5 / 12	GLU A 160 VAL A 123 PRO A  27 THR A  18 GLY A  17	None	1.30A	23.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	4HVC_A_HFGA1602_0 (BIFUNCTIONAL GLUTAMATE/PROLINE--T RNA LIGASE)	5vad	BIFUNCTIONAL GLUTAMATE/PROLINE--T RNA LIGASE (Homo sapiens)	9 / 12	GLU A1100 VAL A1101 TRP A1169 GLU A1171 HIS A1173 PHE A1216 THR A1240 SER A1272 GLY A1274	None None None PRO  A1602 ( 4.7A) PRO  A1602 ( 4.5A) PRO  A1602 (-4.3A) 91Y  A1601 (-4.2A) PRO  A1602 (-3.3A) PRO  A1602 (-3.7A)	0.87A	98.46
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	4HVC_A_HFGA1602_0 (BIFUNCTIONAL GLUTAMATE/PROLINE--T RNA LIGASE)	5vad	BIFUNCTIONAL GLUTAMATE/PROLINE--T RNA LIGASE (Homo sapiens)	5 / 12	GLU A1154 PHE A1216 THR A1240 SER A1272 GLY A1274	91Y  A1601 (-4.6A) PRO  A1602 (-4.3A) 91Y  A1601 (-4.2A) PRO  A1602 (-3.3A) PRO  A1602 (-3.7A)	0.84A	98.46
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	4HVC_A_HFGA1602_0 (BIFUNCTIONAL GLUTAMATE/PROLINE--T RNA LIGASE)	5vad	BIFUNCTIONAL GLUTAMATE/PROLINE--T RNA LIGASE (Homo sapiens)	9 / 12	VAL A1101 PRO A1120 TRP A1169 GLU A1171 HIS A1173 PHE A1216 THR A1240 SER A1272 GLY A1274	None None None PRO  A1602 ( 4.7A) PRO  A1602 ( 4.5A) PRO  A1602 (-4.3A) 91Y  A1601 (-4.2A) PRO  A1602 (-3.3A) PRO  A1602 (-3.7A)	0.64A	98.46
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	4HVC_A_HFGA1602_1 (BIFUNCTIONAL GLUTAMATE/PROLINE--T RNA LIGASE)	5vad	BIFUNCTIONAL GLUTAMATE/PROLINE--T RNA LIGASE (Homo sapiens)	4 / 4	THR A1121 GLU A1123 ARG A1152 HIS A1242	PRO  A1602 (-3.5A) PRO  A1602 (-2.8A) PRO  A1602 ( 3.4A) PRO  A1602 (-4.1A)	0.45A	98.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4HVC_B_HFGB1602_0 (BIFUNCTIONAL GLUTAMATE/PROLINE--T RNA LIGASE)	1t77	LIPOPOLYSACCHARIDE-R ESPONSIVE AND BEIGE-LIKE ANCHOR PROTEIN (Homo sapiens)	5 / 12	LEU A2097 VAL A2176 THR A2231 SER A2236 GLY A2234	None	0.86A	22.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4HVC_B_HFGB1602_0 (BIFUNCTIONAL GLUTAMATE/PROLINE--T RNA LIGASE)	2bkd	FRAGILE X MENTAL RETARDATION 1 PROTEIN (Homo sapiens)	5 / 12	LEU N 112 GLU N  64 VAL N  84 PHE N  15 GLY N  13	None	1.21A	12.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4HVC_B_HFGB1602_0 (BIFUNCTIONAL GLUTAMATE/PROLINE--T RNA LIGASE)	4gs4	ALPHA-TUBULIN N-ACETYLTRANSFERASE (Homo sapiens)	5 / 12	LEU A 164 VAL A 184 PRO A 159 THR A  65 SER A  54	None	1.30A	16.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4HVC_B_HFGB1602_0 (BIFUNCTIONAL GLUTAMATE/PROLINE--T RNA LIGASE)	4if5	ALPHA-TUBULIN N-ACETYLTRANSFERASE (Homo sapiens)	5 / 12	LEU A 164 VAL A 184 PRO A 159 THR A  65 SER A  54	None None None CL  A 202 (-4.0A) None	1.26A	16.47
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	4HVC_B_HFGB1602_0 (BIFUNCTIONAL GLUTAMATE/PROLINE--T RNA LIGASE)	5vad	BIFUNCTIONAL GLUTAMATE/PROLINE--T RNA LIGASE (Homo sapiens)	5 / 12	GLU A1154 PHE A1216 THR A1240 SER A1272 GLY A1274	91Y  A1601 (-4.6A) PRO  A1602 (-4.3A) 91Y  A1601 (-4.2A) PRO  A1602 (-3.3A) PRO  A1602 (-3.7A)	0.94A	98.46
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	4HVC_B_HFGB1602_0 (BIFUNCTIONAL GLUTAMATE/PROLINE--T RNA LIGASE)	5vad	BIFUNCTIONAL GLUTAMATE/PROLINE--T RNA LIGASE (Homo sapiens)	10 / 12	LEU A1087 GLU A1100 VAL A1101 PRO A1120 GLU A1171 HIS A1173 PHE A1216 THR A1240 SER A1272 GLY A1274	None None None None PRO  A1602 ( 4.7A) PRO  A1602 ( 4.5A) PRO  A1602 (-4.3A) 91Y  A1601 (-4.2A) PRO  A1602 (-3.3A) PRO  A1602 (-3.7A)	0.86A	98.46
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	4HVC_B_HFGB1602_0 (BIFUNCTIONAL GLUTAMATE/PROLINE--T RNA LIGASE)	5vad	BIFUNCTIONAL GLUTAMATE/PROLINE--T RNA LIGASE (Homo sapiens)	10 / 12	LEU A1087 GLU A1100 VAL A1101 PRO A1120 TRP A1169 GLU A1171 HIS A1173 THR A1240 SER A1272 GLY A1274	None None None None None PRO  A1602 ( 4.7A) PRO  A1602 ( 4.5A) 91Y  A1601 (-4.2A) PRO  A1602 (-3.3A) PRO  A1602 (-3.7A)	0.66A	98.46
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	4HVC_B_HFGB1602_1 (BIFUNCTIONAL GLUTAMATE/PROLINE--T RNA LIGASE)	5vad	BIFUNCTIONAL GLUTAMATE/PROLINE--T RNA LIGASE (Homo sapiens)	4 / 5	THR A1121 GLU A1123 ARG A1152 HIS A1242	PRO  A1602 (-3.5A) PRO  A1602 (-2.8A) PRO  A1602 ( 3.4A) PRO  A1602 (-4.1A)	0.40A	98.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4K88_A_HFGA602_0 (PROLINE--TRNA LIGASE)	2wim	NEURAL CELL ADHESION MOLECULE 2 (Homo sapiens)	5 / 12	GLU A 119 VAL A 120 THR A 116 ARG A 118 SER A  33	None	1.44A	19.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4K88_A_HFGA602_0 (PROLINE--TRNA LIGASE)	3fe4	CARBONIC ANHYDRASE 6 (Homo sapiens)	5 / 12	GLU A  32 PRO A  49 GLU A 136 TRP A 230 HIS A 111	None None None None MG  A 901 (-3.4A)	1.49A	18.42
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	4K88_A_HFGA602_0 (PROLINE--TRNA LIGASE)	5vad	BIFUNCTIONAL GLUTAMATE/PROLINE--T RNA LIGASE (Homo sapiens)	7 / 12	GLU A1154 PRO A1120 GLU A1123 GLU A1171 PHE A1216 HIS A1242 SER A1272	91Y  A1601 (-4.6A) None PRO  A1602 (-2.8A) PRO  A1602 ( 4.7A) PRO  A1602 (-4.3A) PRO  A1602 (-4.1A) PRO  A1602 (-3.3A)	1.05A	96.63
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	4K88_A_HFGA602_0 (PROLINE--TRNA LIGASE)	5vad	BIFUNCTIONAL GLUTAMATE/PROLINE--T RNA LIGASE (Homo sapiens)	9 / 12	GLU A1154 PRO A1120 THR A1121 GLU A1123 ARG A1152 TRP A1169 GLU A1171 HIS A1242 SER A1272	91Y  A1601 (-4.6A) None PRO  A1602 (-3.5A) PRO  A1602 (-2.8A) PRO  A1602 ( 3.4A) None PRO  A1602 ( 4.7A) PRO  A1602 (-4.1A) PRO  A1602 (-3.3A)	0.94A	96.63
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	4K88_A_HFGA602_0 (PROLINE--TRNA LIGASE)	5vad	BIFUNCTIONAL GLUTAMATE/PROLINE--T RNA LIGASE (Homo sapiens)	7 / 12	VAL A1101 PRO A1120 GLU A1123 GLU A1171 PHE A1216 HIS A1242 SER A1272	None None PRO  A1602 (-2.8A) PRO  A1602 ( 4.7A) PRO  A1602 (-4.3A) PRO  A1602 (-4.1A) PRO  A1602 (-3.3A)	0.83A	96.63
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	4K88_A_HFGA602_0 (PROLINE--TRNA LIGASE)	5vad	BIFUNCTIONAL GLUTAMATE/PROLINE--T RNA LIGASE (Homo sapiens)	9 / 12	VAL A1101 PRO A1120 THR A1121 GLU A1123 ARG A1152 TRP A1169 GLU A1171 HIS A1242 SER A1272	None None PRO  A1602 (-3.5A) PRO  A1602 (-2.8A) PRO  A1602 ( 3.4A) None PRO  A1602 ( 4.7A) PRO  A1602 (-4.1A) PRO  A1602 (-3.3A)	0.64A	96.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4OLF_A_HFGA802_0 (PROLINE--TRNA LIGASE)	1kt8	BRANCHED-CHAIN AMINO ACID AMINOTRANSFERASE, MITOCHONDRIAL (Homo sapiens)	5 / 12	GLU A 288 VAL A 257 PRO A 259 TRP A 194 GLY A 199	None	1.22A	18.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4OLF_A_HFGA802_0 (PROLINE--TRNA LIGASE)	2pbh	PROCATHEPSIN B (Homo sapiens)	5 / 12	GLU A  53 VAL A  54 THR A 223 TRP A 225 GLY A 229	None	1.05A	20.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4OLF_A_HFGA802_0 (PROLINE--TRNA LIGASE)	2ppl	PANCREATIC LIPASE-RELATED PROTEIN 1 (Homo sapiens)	5 / 12	GLU A 179 VAL A 142 PRO A  46 THR A  37 GLY A  36	None	1.45A	22.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4OLF_A_HFGA802_0 (PROLINE--TRNA LIGASE)	2pvs	PANCREATIC LIPASE-RELATED PROTEIN 2 (Homo sapiens)	5 / 12	GLU A 160 VAL A 123 PRO A  27 THR A  18 GLY A  17	None	1.29A	20.55
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	4OLF_A_HFGA802_0 (PROLINE--TRNA LIGASE)	5vad	BIFUNCTIONAL GLUTAMATE/PROLINE--T RNA LIGASE (Homo sapiens)	10 / 12	GLU A1100 VAL A1101 TRP A1169 GLU A1171 HIS A1173 PHE A1216 THR A1240 SER A1272 TRP A1273 GLY A1274	None None None PRO  A1602 ( 4.7A) PRO  A1602 ( 4.5A) PRO  A1602 (-4.3A) 91Y  A1601 (-4.2A) PRO  A1602 (-3.3A) None PRO  A1602 (-3.7A)	0.74A	50.87
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	4OLF_A_HFGA802_0 (PROLINE--TRNA LIGASE)	5vad	BIFUNCTIONAL GLUTAMATE/PROLINE--T RNA LIGASE (Homo sapiens)	7 / 12	GLU A1154 TRP A1169 PHE A1216 THR A1240 SER A1272 TRP A1273 GLY A1274	91Y  A1601 (-4.6A) None PRO  A1602 (-4.3A) 91Y  A1601 (-4.2A) PRO  A1602 (-3.3A) None PRO  A1602 (-3.7A)	0.89A	50.87
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	4OLF_A_HFGA802_0 (PROLINE--TRNA LIGASE)	5vad	BIFUNCTIONAL GLUTAMATE/PROLINE--T RNA LIGASE (Homo sapiens)	10 / 12	VAL A1101 PRO A1120 TRP A1169 GLU A1171 HIS A1173 PHE A1216 THR A1240 SER A1272 TRP A1273 GLY A1274	None None None PRO  A1602 ( 4.7A) PRO  A1602 ( 4.5A) PRO  A1602 (-4.3A) 91Y  A1601 (-4.2A) PRO  A1602 (-3.3A) None PRO  A1602 (-3.7A)	0.56A	50.87
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	4OLF_A_HFGA802_1 (PROLINE--TRNA LIGASE)	5vad	BIFUNCTIONAL GLUTAMATE/PROLINE--T RNA LIGASE (Homo sapiens)	4 / 4	THR A1121 GLU A1123 ARG A1152 HIS A1242	PRO  A1602 (-3.5A) PRO  A1602 (-2.8A) PRO  A1602 ( 3.4A) PRO  A1602 (-4.1A)	0.51A	50.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4Q15_A_HFGA803_0 (PROLINE--TRNA LIGASE)	2bkd	FRAGILE X MENTAL RETARDATION 1 PROTEIN (Homo sapiens)	5 / 12	LEU N 112 GLU N  64 VAL N  84 PHE N  15 GLY N  13	None	1.23A	12.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4Q15_A_HFGA803_0 (PROLINE--TRNA LIGASE)	2dm4	SORTILIN-RELATED RECEPTOR (Homo sapiens)	5 / 12	LEU A  14 GLU A  46 VAL A  80 THR A  77 GLY A  51	None	1.22A	13.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4Q15_A_HFGA803_0 (PROLINE--TRNA LIGASE)	3d3l	ARACHIDONATE 12-LIPOXYGENASE, 12S-TYPE (Homo sapiens)	5 / 12	GLU A 504 VAL A 505 ARG A 500 HIS A 383 PHE A 519	None	1.36A	22.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4Q15_A_HFGA803_0 (PROLINE--TRNA LIGASE)	4jhp	X-LINKED RETINITIS PIGMENTOSA GTPASE REGULATOR (Homo sapiens)	5 / 12	LEU C 145 VAL C 108 THR C  99 HIS C  46 GLY C  65	None	1.32A	20.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4Q15_A_HFGA803_0 (PROLINE--TRNA LIGASE)	4qei	GLYCINE--TRNA LIGASE (Homo sapiens)	5 / 12	LEU A 135 PHE A 144 PRO A 244 ARG A 277 GLY A 406	None None None AMP  A 701 (-2.9A) AMP  A 701 (-4.0A)	1.10A	22.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4Q15_A_HFGA803_0 (PROLINE--TRNA LIGASE)	4qn9	N-ACYL-PHOSPHATIDYLE THANOLAMINE-HYDROLYZ ING PHOSPHOLIPASE D (Homo sapiens)	5 / 12	VAL A 272 THR A 249 TRP A 233 PHE A 291 GLY A  60	None	1.37A	21.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4Q15_A_HFGA803_0 (PROLINE--TRNA LIGASE)	5h1k	GEM-ASSOCIATED PROTEIN 5 (Homo sapiens)	5 / 12	LEU A 375 PHE A  37 VAL A  39 THR A   7 SER A 700	None	1.21A	20.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4Q15_A_HFGA803_0 (PROLINE--TRNA LIGASE)	5l7d	SMOOTHENED HOMOLOG,SOLUBLE CYTOCHROME B562,SMOOTHENED HOMOLOG (Escherichia coli; Homo sapiens)	5 / 12	LEU A 146 VAL A 182 PRO A 124 TRP A 119 GLY A 111	None None None None CLR  A1203 (-4.0A)	1.31A	21.50
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	4Q15_A_HFGA803_0 (PROLINE--TRNA LIGASE)	5vad	BIFUNCTIONAL GLUTAMATE/PROLINE--T RNA LIGASE (Homo sapiens)	10 / 12	LEU A1087 GLU A1100 VAL A1101 PRO A1120 THR A1121 ARG A1152 TRP A1169 HIS A1173 SER A1272 GLY A1274	None None None None PRO  A1602 (-3.5A) PRO  A1602 ( 3.4A) None PRO  A1602 ( 4.5A) PRO  A1602 (-3.3A) PRO  A1602 (-3.7A)	0.78A	50.87
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	4Q15_A_HFGA803_0 (PROLINE--TRNA LIGASE)	5vad	BIFUNCTIONAL GLUTAMATE/PROLINE--T RNA LIGASE (Homo sapiens)	9 / 12	LEU A1087 GLU A1100 VAL A1101 PRO A1120 TRP A1169 HIS A1173 PHE A1216 SER A1272 GLY A1274	None None None None None PRO  A1602 ( 4.5A) PRO  A1602 (-4.3A) PRO  A1602 (-3.3A) PRO  A1602 (-3.7A)	0.95A	50.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4Q15_A_HFGA803_1 (PROLINE--TRNA LIGASE)	1t0p	INTEGRIN ALPHA-L INTERCELLULAR ADHESION MOLECULE-3 (Homo sapiens; Homo sapiens)	3 / 3	GLU A 269 THR B  38 HIS A 264	None	0.82A	16.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4Q15_A_HFGA803_1 (PROLINE--TRNA LIGASE)	1ya0	SMG-7 TRANSCRIPT VARIANT 2 (Homo sapiens)	3 / 3	GLU A 420 THR A 204 HIS A 296	None	0.60A	21.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4Q15_A_HFGA803_1 (PROLINE--TRNA LIGASE)	2b5m	DAMAGE-SPECIFIC DNA BINDING PROTEIN 1 (Homo sapiens)	3 / 3	GLU A 811 THR A 860 HIS A 805	None	0.83A	18.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4Q15_A_HFGA803_1 (PROLINE--TRNA LIGASE)	3iu1	GLYCYLPEPTIDE N-TETRADECANOYLTRANS FERASE 1 (Homo sapiens)	3 / 3	GLU A 370 THR A 354 HIS A 350	None	0.81A	21.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4Q15_A_HFGA803_1 (PROLINE--TRNA LIGASE)	3pzd	MYOSIN-X (Homo sapiens)	3 / 3	GLU A1690 THR A1679 HIS A1719	None	0.81A	21.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4Q15_A_HFGA803_1 (PROLINE--TRNA LIGASE)	4bla	MALTOSE-BINDING PERIPLASMIC PROTEIN, SUPPRESSOR OF FUSED HOMOLOG (Escherichia coli; Homo sapiens)	3 / 3	GLU A 641 THR A 545 HIS A 549	None	0.83A	20.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4Q15_A_HFGA803_1 (PROLINE--TRNA LIGASE)	4bwe	GLYPICAN-1 (Homo sapiens)	3 / 3	GLU A 311 THR A 121 HIS A 318	None	0.67A	22.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4Q15_A_HFGA803_1 (PROLINE--TRNA LIGASE)	4cns	DIHYDROPYRIMIDINASE- LIKE 3 (Homo sapiens)	3 / 3	GLU A 359 THR A 335 HIS A 333	None EDO  A1492 ( 4.9A) None	0.82A	22.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4Q15_A_HFGA803_1 (PROLINE--TRNA LIGASE)	4cns	DIHYDROPYRIMIDINASE- LIKE 3 (Homo sapiens)	3 / 3	GLU A 360 THR A 335 HIS A 333	None EDO  A1492 ( 4.9A) None	0.56A	22.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4Q15_A_HFGA803_1 (PROLINE--TRNA LIGASE)	4cnt	DIHYDROPYRIMIDINASE- LIKE 3 (Homo sapiens)	3 / 3	GLU A 360 THR A 335 HIS A 333	None	0.65A	22.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4Q15_A_HFGA803_1 (PROLINE--TRNA LIGASE)	4nre	ARACHIDONATE 15-LIPOXYGENASE B (Homo sapiens)	3 / 3	GLU A  32 THR A 115 HIS A  70	None	0.84A	21.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4Q15_A_HFGA803_1 (PROLINE--TRNA LIGASE)	5jiu	RAN-BINDING PROTEIN 9 (Homo sapiens)	3 / 3	GLU A 160 THR A 205 HIS A 206	None	0.70A	16.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4Q15_A_HFGA803_1 (PROLINE--TRNA LIGASE)	5nks	DIHYDROPYRIMIDINASE- RELATED PROTEIN 4 (Homo sapiens)	3 / 3	GLU A 360 THR A 335 HIS A 333	GLU  A 360 ( 0.6A) THR  A 335 ( 0.8A) HIS  A 333 ( 1.0A)	0.51A	21.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4Q15_A_HFGA803_1 (PROLINE--TRNA LIGASE)	5v52	T-CELL IMMUNORECEPTOR WITH IG AND ITIM DOMAINS (Homo sapiens)	3 / 3	GLU A  60 THR A 117 HIS A 111	None	0.82A	12.08
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	4Q15_A_HFGA803_1 (PROLINE--TRNA LIGASE)	5vad	BIFUNCTIONAL GLUTAMATE/PROLINE--T RNA LIGASE (Homo sapiens)	3 / 3	GLU A1123 THR A1240 HIS A1242	PRO  A1602 (-2.8A) 91Y  A1601 (-4.2A) PRO  A1602 (-4.1A)	0.45A	50.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4Q15_A_HFGA803_1 (PROLINE--TRNA LIGASE)	5xjy	ATP-BINDING CASSETTE SUB-FAMILY A MEMBER 1 (Homo sapiens)	3 / 3	GLU A1420 THR A1630 HIS A 551	None	0.78A	12.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4Q15_A_HFGA803_1 (PROLINE--TRNA LIGASE)	6gru	ADP-SUGAR PYROPHOSPHATASE (Homo sapiens)	3 / 3	GLU A 106 THR A  58 HIS A 142	None	0.62A	undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4Q15_B_HFGB803_0 (PROLINE--TRNA LIGASE)	1t5c	CENTROMERIC PROTEIN E (Homo sapiens)	5 / 12	LEU A  16 VAL A  29 PRO A 310 THR A 309 GLY A  86	None	1.34A	19.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4Q15_B_HFGB803_0 (PROLINE--TRNA LIGASE)	3ifw	UBIQUITIN CARBOXYL-TERMINAL HYDROLASE ISOZYME L1 (Homo sapiens)	5 / 12	LEU A 219 VAL A  99 GLU A 190 SER A 188 GLY A 170	None	1.28A	17.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4Q15_B_HFGB803_0 (PROLINE--TRNA LIGASE)	3wtd	UNCHARACTERIZED PROTEIN C9ORF142 (Homo sapiens)	5 / 12	LEU A  98 GLU A  81 THR A  73 ARG A  77 GLU A  27	None	1.29A	14.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4Q15_B_HFGB803_0 (PROLINE--TRNA LIGASE)	4po6	NON-RECEPTOR TYROSINE-PROTEIN KINASE TYK2 (Homo sapiens)	5 / 12	LEU A 419 GLU A 315 VAL A 275 THR A 272 ARG A 274	None None None GOL  A 603 (-4.2A) GOL  A 603 (-4.2A)	1.23A	20.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4Q15_B_HFGB803_0 (PROLINE--TRNA LIGASE)	4qei	GLYCINE--TRNA LIGASE (Homo sapiens)	5 / 12	LEU A 135 PRO A 244 ARG A 277 GLU A 296 GLY A 406	None None AMP  A 701 (-2.9A) None AMP  A 701 (-4.0A)	1.01A	22.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4Q15_B_HFGB803_0 (PROLINE--TRNA LIGASE)	4qn9	N-ACYL-PHOSPHATIDYLE THANOLAMINE-HYDROLYZ ING PHOSPHOLIPASE D (Homo sapiens)	5 / 12	VAL A 272 THR A 249 TRP A 233 PHE A 291 GLY A  60	None	1.34A	21.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4Q15_B_HFGB803_0 (PROLINE--TRNA LIGASE)	5h1k	GEM-ASSOCIATED PROTEIN 5 (Homo sapiens)	5 / 12	LEU A 375 PHE A  37 VAL A  39 THR A   7 SER A 700	None	1.23A	20.30
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	4Q15_B_HFGB803_0 (PROLINE--TRNA LIGASE)	5vad	BIFUNCTIONAL GLUTAMATE/PROLINE--T RNA LIGASE (Homo sapiens)	9 / 12	LEU A1087 GLU A1100 VAL A1101 PRO A1120 THR A1121 ARG A1152 TRP A1169 GLU A1171 GLY A1274	None None None None PRO  A1602 (-3.5A) PRO  A1602 ( 3.4A) None PRO  A1602 ( 4.7A) PRO  A1602 (-3.7A)	0.74A	50.87
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	4Q15_B_HFGB803_0 (PROLINE--TRNA LIGASE)	5vad	BIFUNCTIONAL GLUTAMATE/PROLINE--T RNA LIGASE (Homo sapiens)	8 / 12	LEU A1087 GLU A1100 VAL A1101 PRO A1120 TRP A1169 GLU A1171 PHE A1216 GLY A1274	None None None None None PRO  A1602 ( 4.7A) PRO  A1602 (-4.3A) PRO  A1602 (-3.7A)	0.95A	50.87
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	4Q15_B_HFGB803_0 (PROLINE--TRNA LIGASE)	5vad	BIFUNCTIONAL GLUTAMATE/PROLINE--T RNA LIGASE (Homo sapiens)	9 / 12	LEU A1087 VAL A1101 PRO A1120 THR A1121 ARG A1152 TRP A1169 GLU A1171 SER A1272 GLY A1274	None None None PRO  A1602 (-3.5A) PRO  A1602 ( 3.4A) None PRO  A1602 ( 4.7A) PRO  A1602 (-3.3A) PRO  A1602 (-3.7A)	0.56A	50.87
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	4Q15_B_HFGB803_0 (PROLINE--TRNA LIGASE)	5vad	BIFUNCTIONAL GLUTAMATE/PROLINE--T RNA LIGASE (Homo sapiens)	8 / 12	LEU A1087 VAL A1101 PRO A1120 TRP A1169 GLU A1171 PHE A1216 SER A1272 GLY A1274	None None None None PRO  A1602 ( 4.7A) PRO  A1602 (-4.3A) PRO  A1602 (-3.3A) PRO  A1602 (-3.7A)	0.76A	50.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4Q15_B_HFGB803_1 (PROLINE--TRNA LIGASE)	1t0p	INTEGRIN ALPHA-L INTERCELLULAR ADHESION MOLECULE-3 (Homo sapiens; Homo sapiens)	3 / 3	GLU A 269 THR B  38 HIS A 264	None	0.84A	16.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4Q15_B_HFGB803_1 (PROLINE--TRNA LIGASE)	1ya0	SMG-7 TRANSCRIPT VARIANT 2 (Homo sapiens)	3 / 3	GLU A 420 THR A 204 HIS A 296	None	0.62A	21.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4Q15_B_HFGB803_1 (PROLINE--TRNA LIGASE)	2b5m	DAMAGE-SPECIFIC DNA BINDING PROTEIN 1 (Homo sapiens)	3 / 3	GLU A 811 THR A 860 HIS A 805	None	0.81A	18.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4Q15_B_HFGB803_1 (PROLINE--TRNA LIGASE)	3iu1	GLYCYLPEPTIDE N-TETRADECANOYLTRANS FERASE 1 (Homo sapiens)	3 / 3	GLU A 370 THR A 354 HIS A 350	None	0.79A	21.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4Q15_B_HFGB803_1 (PROLINE--TRNA LIGASE)	3pzd	MYOSIN-X (Homo sapiens)	3 / 3	GLU A1690 THR A1679 HIS A1719	None	0.80A	21.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4Q15_B_HFGB803_1 (PROLINE--TRNA LIGASE)	4bla	MALTOSE-BINDING PERIPLASMIC PROTEIN, SUPPRESSOR OF FUSED HOMOLOG (Escherichia coli; Homo sapiens)	3 / 3	GLU A 641 THR A 545 HIS A 549	None	0.82A	20.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4Q15_B_HFGB803_1 (PROLINE--TRNA LIGASE)	4bwe	GLYPICAN-1 (Homo sapiens)	3 / 3	GLU A 311 THR A 121 HIS A 318	None	0.67A	22.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4Q15_B_HFGB803_1 (PROLINE--TRNA LIGASE)	4cns	DIHYDROPYRIMIDINASE- LIKE 3 (Homo sapiens)	3 / 3	GLU A 359 THR A 335 HIS A 333	None EDO  A1492 ( 4.9A) None	0.82A	22.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4Q15_B_HFGB803_1 (PROLINE--TRNA LIGASE)	4cns	DIHYDROPYRIMIDINASE- LIKE 3 (Homo sapiens)	3 / 3	GLU A 360 THR A 335 HIS A 333	None EDO  A1492 ( 4.9A) None	0.55A	22.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4Q15_B_HFGB803_1 (PROLINE--TRNA LIGASE)	4cnt	DIHYDROPYRIMIDINASE- LIKE 3 (Homo sapiens)	3 / 3	GLU A 360 THR A 335 HIS A 333	None	0.66A	22.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4Q15_B_HFGB803_1 (PROLINE--TRNA LIGASE)	4nre	ARACHIDONATE 15-LIPOXYGENASE B (Homo sapiens)	3 / 3	GLU A  32 THR A 115 HIS A  70	None	0.83A	21.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4Q15_B_HFGB803_1 (PROLINE--TRNA LIGASE)	5fqd	DNA DAMAGE-BINDING PROTEIN 1 (Homo sapiens)	3 / 3	GLU A 811 THR A 860 HIS A 805	None	0.86A	20.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4Q15_B_HFGB803_1 (PROLINE--TRNA LIGASE)	5jiu	RAN-BINDING PROTEIN 9 (Homo sapiens)	3 / 3	GLU A 160 THR A 205 HIS A 206	None	0.71A	16.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4Q15_B_HFGB803_1 (PROLINE--TRNA LIGASE)	5nks	DIHYDROPYRIMIDINASE- RELATED PROTEIN 4 (Homo sapiens)	3 / 3	GLU A 359 THR A 335 HIS A 333	GLU  A 359 ( 0.6A) THR  A 335 ( 0.8A) HIS  A 333 ( 1.0A)	0.87A	21.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4Q15_B_HFGB803_1 (PROLINE--TRNA LIGASE)	5nks	DIHYDROPYRIMIDINASE- RELATED PROTEIN 4 (Homo sapiens)	3 / 3	GLU A 360 THR A 335 HIS A 333	GLU  A 360 ( 0.6A) THR  A 335 ( 0.8A) HIS  A 333 ( 1.0A)	0.50A	21.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4Q15_B_HFGB803_1 (PROLINE--TRNA LIGASE)	5v52	T-CELL IMMUNORECEPTOR WITH IG AND ITIM DOMAINS (Homo sapiens)	3 / 3	GLU A  60 THR A 117 HIS A 111	None	0.81A	12.08
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	4Q15_B_HFGB803_1 (PROLINE--TRNA LIGASE)	5vad	BIFUNCTIONAL GLUTAMATE/PROLINE--T RNA LIGASE (Homo sapiens)	3 / 3	GLU A1123 THR A1240 HIS A1242	PRO  A1602 (-2.8A) 91Y  A1601 (-4.2A) PRO  A1602 (-4.1A)	0.50A	50.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4Q15_B_HFGB803_1 (PROLINE--TRNA LIGASE)	5xjy	ATP-BINDING CASSETTE SUB-FAMILY A MEMBER 1 (Homo sapiens)	3 / 3	GLU A1420 THR A1630 HIS A 551	None	0.77A	12.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4Q15_B_HFGB803_1 (PROLINE--TRNA LIGASE)	6gru	ADP-SUGAR PYROPHOSPHATASE (Homo sapiens)	3 / 3	GLU A 106 THR A  58 HIS A 142	None	0.60A	undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4YDQ_A_HFGA802_0 (PROLINE--TRNA LIGASE)	2yl2	ACETYL-COA CARBOXYLASE 1 (Homo sapiens)	5 / 12	LEU A 448 GLU A 474 VAL A 460 TRP A 297 GLY A 326	None	1.33A	22.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4YDQ_A_HFGA802_0 (PROLINE--TRNA LIGASE)	4qei	GLYCINE--TRNA LIGASE (Homo sapiens)	5 / 12	LEU A 135 PHE A 144 ARG A 277 GLU A 296 GLY A 406	None None AMP  A 701 (-2.9A) None AMP  A 701 (-4.0A)	1.20A	23.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4YDQ_A_HFGA802_0 (PROLINE--TRNA LIGASE)	4qei	GLYCINE--TRNA LIGASE (Homo sapiens)	5 / 12	LEU A 135 PRO A 244 ARG A 277 GLU A 296 GLY A 406	None None AMP  A 701 (-2.9A) None AMP  A 701 (-4.0A)	0.99A	23.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4YDQ_A_HFGA802_0 (PROLINE--TRNA LIGASE)	5u7z	ACID CERAMIDASE (Homo sapiens)	5 / 12	LEU B 221 PHE B 199 GLU B 258 VAL B 256 GLY B 206	None None NAG  B 404 ( 2.7A) None None	1.38A	undetectable
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	4YDQ_A_HFGA802_0 (PROLINE--TRNA LIGASE)	5vad	BIFUNCTIONAL GLUTAMATE/PROLINE--T RNA LIGASE (Homo sapiens)	5 / 12	GLU A1154 ARG A1152 TRP A1169 SER A1272 GLY A1274	91Y  A1601 (-4.6A) PRO  A1602 ( 3.4A) None PRO  A1602 (-3.3A) PRO  A1602 (-3.7A)	1.12A	50.87
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	4YDQ_A_HFGA802_0 (PROLINE--TRNA LIGASE)	5vad	BIFUNCTIONAL GLUTAMATE/PROLINE--T RNA LIGASE (Homo sapiens)	6 / 12	LEU A1087 GLU A1100 VAL A1101 ARG A1152 GLU A1171 GLY A1274	None None None PRO  A1602 ( 3.4A) PRO  A1602 ( 4.7A) PRO  A1602 (-3.7A)	0.87A	50.87
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	4YDQ_A_HFGA802_0 (PROLINE--TRNA LIGASE)	5vad	BIFUNCTIONAL GLUTAMATE/PROLINE--T RNA LIGASE (Homo sapiens)	6 / 12	LEU A1087 GLU A1100 VAL A1101 ARG A1152 TRP A1169 GLY A1274	None None None PRO  A1602 ( 3.4A) None PRO  A1602 (-3.7A)	1.06A	50.87
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	4YDQ_A_HFGA802_0 (PROLINE--TRNA LIGASE)	5vad	BIFUNCTIONAL GLUTAMATE/PROLINE--T RNA LIGASE (Homo sapiens)	5 / 12	LEU A1087 PHE A1097 VAL A1101 PHE A1216 GLY A1172	None None None PRO  A1602 (-4.3A) None	1.30A	50.87
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	4YDQ_A_HFGA802_0 (PROLINE--TRNA LIGASE)	5vad	BIFUNCTIONAL GLUTAMATE/PROLINE--T RNA LIGASE (Homo sapiens)	8 / 12	LEU A1087 VAL A1101 PRO A1120 ARG A1152 GLU A1171 HIS A1173 SER A1272 GLY A1274	None None None PRO  A1602 ( 3.4A) PRO  A1602 ( 4.7A) PRO  A1602 ( 4.5A) PRO  A1602 (-3.3A) PRO  A1602 (-3.7A)	0.61A	50.87
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	4YDQ_A_HFGA802_0 (PROLINE--TRNA LIGASE)	5vad	BIFUNCTIONAL GLUTAMATE/PROLINE--T RNA LIGASE (Homo sapiens)	7 / 12	LEU A1087 VAL A1101 PRO A1120 ARG A1152 TRP A1169 SER A1272 GLY A1274	None None None PRO  A1602 ( 3.4A) None PRO  A1602 (-3.3A) PRO  A1602 (-3.7A)	0.86A	50.87
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	4YDQ_A_HFGA802_0 (PROLINE--TRNA LIGASE)	5vad	BIFUNCTIONAL GLUTAMATE/PROLINE--T RNA LIGASE (Homo sapiens)	8 / 12	LEU A1087 VAL A1101 PRO A1120 GLU A1171 HIS A1173 PHE A1216 SER A1272 GLY A1274	None None None PRO  A1602 ( 4.7A) PRO  A1602 ( 4.5A) PRO  A1602 (-4.3A) PRO  A1602 (-3.3A) PRO  A1602 (-3.7A)	0.76A	50.87
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	4YDQ_A_HFGA802_1 (PROLINE--TRNA LIGASE)	5vad	BIFUNCTIONAL GLUTAMATE/PROLINE--T RNA LIGASE (Homo sapiens)	4 / 4	THR A1121 GLU A1123 THR A1240 HIS A1242	PRO  A1602 (-3.5A) PRO  A1602 (-2.8A) 91Y  A1601 (-4.2A) PRO  A1602 (-4.1A)	0.54A	50.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4YDQ_B_HFGB802_0 (PROLINE--TRNA LIGASE)	3ojy	COMPLEMENT COMPONENT C8 BETA CHAIN (Homo sapiens)	5 / 12	PHE B 210 GLU B 192 GLU B 246 HIS B 249 GLY B 297	None	1.13A	23.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4YDQ_B_HFGB802_0 (PROLINE--TRNA LIGASE)	5m6u	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT DELTA ISOFORM (Homo sapiens)	5 / 12	PRO A 817 THR A 818 TRP A 649 PHE A 778 GLY A 686	None	1.38A	17.61
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	4YDQ_B_HFGB802_0 (PROLINE--TRNA LIGASE)	5vad	BIFUNCTIONAL GLUTAMATE/PROLINE--T RNA LIGASE (Homo sapiens)	5 / 12	GLU A1154 ARG A1152 TRP A1169 SER A1272 GLY A1274	91Y  A1601 (-4.6A) PRO  A1602 ( 3.4A) None PRO  A1602 (-3.3A) PRO  A1602 (-3.7A)	1.12A	50.87
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	4YDQ_B_HFGB802_0 (PROLINE--TRNA LIGASE)	5vad	BIFUNCTIONAL GLUTAMATE/PROLINE--T RNA LIGASE (Homo sapiens)	8 / 12	VAL A1101 PRO A1120 THR A1121 ARG A1152 GLU A1171 HIS A1173 SER A1272 GLY A1274	None None PRO  A1602 (-3.5A) PRO  A1602 ( 3.4A) PRO  A1602 ( 4.7A) PRO  A1602 ( 4.5A) PRO  A1602 (-3.3A) PRO  A1602 (-3.7A)	0.49A	50.87
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	4YDQ_B_HFGB802_0 (PROLINE--TRNA LIGASE)	5vad	BIFUNCTIONAL GLUTAMATE/PROLINE--T RNA LIGASE (Homo sapiens)	8 / 12	VAL A1101 PRO A1120 THR A1121 ARG A1152 TRP A1169 HIS A1173 SER A1272 GLY A1274	None None PRO  A1602 (-3.5A) PRO  A1602 ( 3.4A) None PRO  A1602 ( 4.5A) PRO  A1602 (-3.3A) PRO  A1602 (-3.7A)	0.79A	50.87
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	4YDQ_B_HFGB802_0 (PROLINE--TRNA LIGASE)	5vad	BIFUNCTIONAL GLUTAMATE/PROLINE--T RNA LIGASE (Homo sapiens)	8 / 12	VAL A1101 PRO A1120 THR A1121 GLU A1171 HIS A1173 PHE A1216 SER A1272 GLY A1274	None None PRO  A1602 (-3.5A) PRO  A1602 ( 4.7A) PRO  A1602 ( 4.5A) PRO  A1602 (-4.3A) PRO  A1602 (-3.3A) PRO  A1602 (-3.7A)	0.69A	50.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4YDQ_B_HFGB802_1 (PROLINE--TRNA LIGASE)	1olx	2-OXOISOVALERATE DEHYDROGENASE BETA SUBUNIT (Homo sapiens)	3 / 3	GLU B 322 THR B 229 HIS B   3	None	0.82A	21.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4YDQ_B_HFGB802_1 (PROLINE--TRNA LIGASE)	1t0p	INTEGRIN ALPHA-L INTERCELLULAR ADHESION MOLECULE-3 (Homo sapiens; Homo sapiens)	3 / 3	GLU A 269 THR B  38 HIS A 264	None	0.83A	16.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4YDQ_B_HFGB802_1 (PROLINE--TRNA LIGASE)	1ya0	SMG-7 TRANSCRIPT VARIANT 2 (Homo sapiens)	3 / 3	GLU A 420 THR A 204 HIS A 296	None	0.61A	20.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4YDQ_B_HFGB802_1 (PROLINE--TRNA LIGASE)	2b5m	DAMAGE-SPECIFIC DNA BINDING PROTEIN 1 (Homo sapiens)	3 / 3	GLU A 811 THR A 860 HIS A 805	None	0.83A	17.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4YDQ_B_HFGB802_1 (PROLINE--TRNA LIGASE)	2efl	FORMIN-BINDING PROTEIN 1 (Homo sapiens)	3 / 3	GLU A 200 THR A 207 HIS A 208	None	0.83A	20.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4YDQ_B_HFGB802_1 (PROLINE--TRNA LIGASE)	3iu1	GLYCYLPEPTIDE N-TETRADECANOYLTRANS FERASE 1 (Homo sapiens)	3 / 3	GLU A 370 THR A 354 HIS A 350	None	0.81A	21.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4YDQ_B_HFGB802_1 (PROLINE--TRNA LIGASE)	4bla	MALTOSE-BINDING PERIPLASMIC PROTEIN, SUPPRESSOR OF FUSED HOMOLOG (Escherichia coli; Homo sapiens)	3 / 3	GLU A 641 THR A 545 HIS A 549	None	0.74A	20.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4YDQ_B_HFGB802_1 (PROLINE--TRNA LIGASE)	4bwe	GLYPICAN-1 (Homo sapiens)	3 / 3	GLU A 311 THR A 121 HIS A 318	None	0.65A	21.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4YDQ_B_HFGB802_1 (PROLINE--TRNA LIGASE)	4cns	DIHYDROPYRIMIDINASE- LIKE 3 (Homo sapiens)	3 / 3	GLU A 359 THR A 335 HIS A 333	None EDO  A1492 ( 4.9A) None	0.77A	22.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4YDQ_B_HFGB802_1 (PROLINE--TRNA LIGASE)	4cns	DIHYDROPYRIMIDINASE- LIKE 3 (Homo sapiens)	3 / 3	GLU A 360 THR A 335 HIS A 333	None EDO  A1492 ( 4.9A) None	0.58A	22.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4YDQ_B_HFGB802_1 (PROLINE--TRNA LIGASE)	4cnt	DIHYDROPYRIMIDINASE- LIKE 3 (Homo sapiens)	3 / 3	GLU A 360 THR A 335 HIS A 333	None	0.62A	21.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4YDQ_B_HFGB802_1 (PROLINE--TRNA LIGASE)	4h27	L-SERINE DEHYDRATASE/L-THREON INE DEAMINASE (Homo sapiens)	3 / 3	GLU A 244 THR A 206 HIS A 202	None	0.82A	19.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4YDQ_B_HFGB802_1 (PROLINE--TRNA LIGASE)	4nre	ARACHIDONATE 15-LIPOXYGENASE B (Homo sapiens)	3 / 3	GLU A  32 THR A 115 HIS A  70	None	0.81A	20.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4YDQ_B_HFGB802_1 (PROLINE--TRNA LIGASE)	5jiu	RAN-BINDING PROTEIN 9 (Homo sapiens)	3 / 3	GLU A 160 THR A 205 HIS A 206	None	0.71A	16.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4YDQ_B_HFGB802_1 (PROLINE--TRNA LIGASE)	5nks	DIHYDROPYRIMIDINASE- RELATED PROTEIN 4 (Homo sapiens)	3 / 3	GLU A 360 THR A 335 HIS A 333	GLU  A 360 ( 0.6A) THR  A 335 ( 0.8A) HIS  A 333 ( 1.0A)	0.52A	21.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4YDQ_B_HFGB802_1 (PROLINE--TRNA LIGASE)	5v52	T-CELL IMMUNORECEPTOR WITH IG AND ITIM DOMAINS (Homo sapiens)	3 / 3	GLU A  60 THR A 117 HIS A 111	None	0.74A	12.10
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	4YDQ_B_HFGB802_1 (PROLINE--TRNA LIGASE)	5vad	BIFUNCTIONAL GLUTAMATE/PROLINE--T RNA LIGASE (Homo sapiens)	3 / 3	GLU A1123 THR A1240 HIS A1242	PRO  A1602 (-2.8A) 91Y  A1601 (-4.2A) PRO  A1602 (-4.1A)	0.40A	50.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4YDQ_B_HFGB802_1 (PROLINE--TRNA LIGASE)	5xjy	ATP-BINDING CASSETTE SUB-FAMILY A MEMBER 1 (Homo sapiens)	3 / 3	GLU A1420 THR A1630 HIS A 551	None	0.76A	11.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4YDQ_B_HFGB802_1 (PROLINE--TRNA LIGASE)	6gru	ADP-SUGAR PYROPHOSPHATASE (Homo sapiens)	3 / 3	GLU A 106 THR A  58 HIS A 142	None	0.63A	undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5F9Z_A_HFGA702_0 (AMINOACYL-TRNA SYNTHETASE)	2c47	CASEIN KINASE 1 GAMMA 2 ISOFORM (Homo sapiens)	5 / 12	GLY A 239 GLU A 236 VAL A 294 ARG A 295 GLU A 277	None	1.32A	21.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5F9Z_A_HFGA702_0 (AMINOACYL-TRNA SYNTHETASE)	2jbm	NICOTINATE-NUCLEOTID E PYROPHOSPHORYLASE (Homo sapiens)	5 / 12	LEU A  20 GLY A 145 VAL A 149 ARG A 147 GLY A 167	None	1.35A	20.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5F9Z_A_HFGA702_0 (AMINOACYL-TRNA SYNTHETASE)	2wd9	ACYL-COENZYME A SYNTHETASE ACSM2A, MITOCHONDRIAL (Homo sapiens)	5 / 12	LEU A 267 GLY A 470 GLU A 339 VAL A 337 PHE A 291	IBP  A1570 (-3.7A) None None IBP  A1570 (-4.6A) None	1.27A	23.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5F9Z_A_HFGA702_0 (AMINOACYL-TRNA SYNTHETASE)	2yl2	ACETYL-COA CARBOXYLASE 1 (Homo sapiens)	5 / 12	LEU A 448 GLY A 278 VAL A 460 TRP A 297 GLY A 326	None	1.32A	22.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5F9Z_A_HFGA702_0 (AMINOACYL-TRNA SYNTHETASE)	3ihw	CENTG3 (Homo sapiens)	5 / 12	LEU A 182 GLY A  95 VAL A 191 SER A 102 GLY A 197	None	1.07A	17.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5F9Z_A_HFGA702_0 (AMINOACYL-TRNA SYNTHETASE)	4qei	GLYCINE--TRNA LIGASE (Homo sapiens)	5 / 12	LEU A 135 PRO A 244 ARG A 277 GLU A 296 GLY A 406	None None AMP  A 701 (-2.9A) None AMP  A 701 (-4.0A)	0.93A	22.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5F9Z_A_HFGA702_0 (AMINOACYL-TRNA SYNTHETASE)	4wtx	INTEGRIN BETA-4 (Homo sapiens)	5 / 12	LEU A1589 GLY A1660 GLU A1659 VAL A1646 GLY A1614	None	1.28A	13.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5F9Z_A_HFGA702_0 (AMINOACYL-TRNA SYNTHETASE)	4wtx	INTEGRIN BETA-4 (Homo sapiens)	5 / 12	LEU A1589 GLY A1660 GLU A1659 VAL A1646 GLY A1615	None	1.06A	13.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5F9Z_A_HFGA702_0 (AMINOACYL-TRNA SYNTHETASE)	5a1k	ADSEVERIN (Homo sapiens)	5 / 12	LEU A 220 GLY A 214 GLU A 212 VAL A 211 GLY A 233	None	1.20A	21.02
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	5F9Z_A_HFGA702_0 (AMINOACYL-TRNA SYNTHETASE)	5vad	BIFUNCTIONAL GLUTAMATE/PROLINE--T RNA LIGASE (Homo sapiens)	9 / 12	LEU A1087 GLU A1100 VAL A1101 ARG A1152 TRP A1169 GLU A1171 PHE A1216 SER A1272 GLY A1274	None None None PRO  A1602 ( 3.4A) None PRO  A1602 ( 4.7A) PRO  A1602 (-4.3A) PRO  A1602 (-3.3A) PRO  A1602 (-3.7A)	0.93A	54.32
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	5F9Z_A_HFGA702_0 (AMINOACYL-TRNA SYNTHETASE)	5vad	BIFUNCTIONAL GLUTAMATE/PROLINE--T RNA LIGASE (Homo sapiens)	9 / 12	LEU A1087 VAL A1101 PRO A1120 ARG A1152 TRP A1169 GLU A1171 PHE A1216 SER A1272 GLY A1274	None None None PRO  A1602 ( 3.4A) None PRO  A1602 ( 4.7A) PRO  A1602 (-4.3A) PRO  A1602 (-3.3A) PRO  A1602 (-3.7A)	0.72A	54.32
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	5F9Z_A_HFGA702_1 (AMINOACYL-TRNA SYNTHETASE)	5vad	BIFUNCTIONAL GLUTAMATE/PROLINE--T RNA LIGASE (Homo sapiens)	4 / 4	THR A1121 GLU A1123 THR A1240 HIS A1242	PRO  A1602 (-3.5A) PRO  A1602 (-2.8A) 91Y  A1601 (-4.2A) PRO  A1602 (-4.1A)	0.52A	54.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5F9Z_B_HFGB703_0 (AMINOACYL-TRNA SYNTHETASE)	2vre	DELTA(3,5)-DELTA(2,4 )-DIENOYL-COA ISOMERASE (Homo sapiens)	5 / 12	PHE A  67 GLU A 131 VAL A 129 PHE A  88 GLY A 147	None	1.27A	20.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5F9Z_B_HFGB703_0 (AMINOACYL-TRNA SYNTHETASE)	3s95	LIM DOMAIN KINASE 1 (Homo sapiens)	5 / 12	LEU A 600 PHE A 535 VAL A 532 PRO A 595 GLY A 627	None None None GOL  A   6 ( 4.6A) None	1.33A	20.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5F9Z_B_HFGB703_0 (AMINOACYL-TRNA SYNTHETASE)	4qei	GLYCINE--TRNA LIGASE (Homo sapiens)	5 / 12	LEU A 135 PRO A 244 ARG A 277 GLU A 296 GLY A 406	None None AMP  A 701 (-2.9A) None AMP  A 701 (-4.0A)	0.90A	22.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5F9Z_B_HFGB703_0 (AMINOACYL-TRNA SYNTHETASE)	4ruh	CYTOSOLIC NON-SPECIFIC DIPEPTIDASE (Homo sapiens)	5 / 12	LEU A 451 VAL A 437 PRO A 136 SER A  30 GLY A 164	None	1.37A	22.74
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	5F9Z_B_HFGB703_0 (AMINOACYL-TRNA SYNTHETASE)	5vad	BIFUNCTIONAL GLUTAMATE/PROLINE--T RNA LIGASE (Homo sapiens)	9 / 12	LEU A1087 GLU A1100 VAL A1101 PRO A1120 ARG A1152 TRP A1169 GLU A1171 SER A1272 GLY A1274	None None None None PRO  A1602 ( 3.4A) None PRO  A1602 ( 4.7A) PRO  A1602 (-3.3A) PRO  A1602 (-3.7A)	0.77A	54.32
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	5F9Z_B_HFGB703_0 (AMINOACYL-TRNA SYNTHETASE)	5vad	BIFUNCTIONAL GLUTAMATE/PROLINE--T RNA LIGASE (Homo sapiens)	8 / 12	LEU A1087 VAL A1101 PRO A1120 TRP A1169 GLU A1171 PHE A1216 SER A1272 GLY A1274	None None None None PRO  A1602 ( 4.7A) PRO  A1602 (-4.3A) PRO  A1602 (-3.3A) PRO  A1602 (-3.7A)	0.72A	54.32
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	5F9Z_B_HFGB703_1 (AMINOACYL-TRNA SYNTHETASE)	5vad	BIFUNCTIONAL GLUTAMATE/PROLINE--T RNA LIGASE (Homo sapiens)	4 / 4	THR A1121 GLU A1123 THR A1240 HIS A1242	PRO  A1602 (-3.5A) PRO  A1602 (-2.8A) 91Y  A1601 (-4.2A) PRO  A1602 (-4.1A)	0.52A	54.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5XIO_A_HFGA801_0 (PROLINE-TRNA SYNTHETASE CLASS II AARS (YBAK RNA BINDING DOMAIN PLUS TRNA SYNTHETASE))	1kwm	PROCARBOXYPEPTIDASE B (Homo sapiens)	5 / 12	GLU A  72 PRO A 143 THR A  44 SER A 157 GLY A 155	ZN  A 400 (-2.1A) None None None None	1.47A	21.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5XIO_A_HFGA801_0 (PROLINE-TRNA SYNTHETASE CLASS II AARS (YBAK RNA BINDING DOMAIN PLUS TRNA SYNTHETASE))	3h2u	RAVER-1 (Homo sapiens)	5 / 12	PHE B 162 GLU B  52 HIS B 206 THR B 130 GLY B 211	None	1.42A	18.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5XIO_A_HFGA801_0 (PROLINE-TRNA SYNTHETASE CLASS II AARS (YBAK RNA BINDING DOMAIN PLUS TRNA SYNTHETASE))	3ifw	UBIQUITIN CARBOXYL-TERMINAL HYDROLASE ISOZYME L1 (Homo sapiens)	5 / 12	VAL A  75 PRO A 182 HIS A 161 PHE A 165 GLY A  94	None	1.42A	18.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5XIO_A_HFGA801_0 (PROLINE-TRNA SYNTHETASE CLASS II AARS (YBAK RNA BINDING DOMAIN PLUS TRNA SYNTHETASE))	5ugf	PURINE NUCLEOSIDE PHOSPHORYLASE (Homo sapiens)	5 / 12	GLU A  89 PRO A 198 GLU A 201 THR A 242 GLY A 118	None None IM5  A 308 (-2.9A) IM5  A 308 (-4.3A) IM5  A 308 (-3.7A)	1.12A	19.96
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	5XIO_A_HFGA801_0 (PROLINE-TRNA SYNTHETASE CLASS II AARS (YBAK RNA BINDING DOMAIN PLUS TRNA SYNTHETASE))	5vad	BIFUNCTIONAL GLUTAMATE/PROLINE--T RNA LIGASE (Homo sapiens)	9 / 12	GLU A1154 PRO A1120 ARG A1152 TRP A1169 GLU A1171 HIS A1173 THR A1240 SER A1272 GLY A1274	91Y  A1601 (-4.6A) None PRO  A1602 ( 3.4A) None PRO  A1602 ( 4.7A) PRO  A1602 ( 4.5A) 91Y  A1601 (-4.2A) PRO  A1602 (-3.3A) PRO  A1602 (-3.7A)	0.88A	54.34
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	5XIO_A_HFGA801_0 (PROLINE-TRNA SYNTHETASE CLASS II AARS (YBAK RNA BINDING DOMAIN PLUS TRNA SYNTHETASE))	5vad	BIFUNCTIONAL GLUTAMATE/PROLINE--T RNA LIGASE (Homo sapiens)	8 / 12	GLU A1154 PRO A1120 GLU A1171 HIS A1173 PHE A1216 THR A1240 SER A1272 GLY A1274	91Y  A1601 (-4.6A) None PRO  A1602 ( 4.7A) PRO  A1602 ( 4.5A) PRO  A1602 (-4.3A) 91Y  A1601 (-4.2A) PRO  A1602 (-3.3A) PRO  A1602 (-3.7A)	0.96A	54.34
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	5XIO_A_HFGA801_0 (PROLINE-TRNA SYNTHETASE CLASS II AARS (YBAK RNA BINDING DOMAIN PLUS TRNA SYNTHETASE))	5vad	BIFUNCTIONAL GLUTAMATE/PROLINE--T RNA LIGASE (Homo sapiens)	6 / 12	VAL A1101 PRO A1120 ARG A1152 HIS A1173 THR A1222 SER A1272	None None PRO  A1602 ( 3.4A) PRO  A1602 ( 4.5A) None PRO  A1602 (-3.3A)	1.42A	54.34
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	5XIO_A_HFGA801_0 (PROLINE-TRNA SYNTHETASE CLASS II AARS (YBAK RNA BINDING DOMAIN PLUS TRNA SYNTHETASE))	5vad	BIFUNCTIONAL GLUTAMATE/PROLINE--T RNA LIGASE (Homo sapiens)	9 / 12	VAL A1101 PRO A1120 ARG A1152 TRP A1169 GLU A1171 HIS A1173 THR A1240 SER A1272 GLY A1274	None None PRO  A1602 ( 3.4A) None PRO  A1602 ( 4.7A) PRO  A1602 ( 4.5A) 91Y  A1601 (-4.2A) PRO  A1602 (-3.3A) PRO  A1602 (-3.7A)	0.60A	54.34
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	5XIO_A_HFGA801_0 (PROLINE-TRNA SYNTHETASE CLASS II AARS (YBAK RNA BINDING DOMAIN PLUS TRNA SYNTHETASE))	5vad	BIFUNCTIONAL GLUTAMATE/PROLINE--T RNA LIGASE (Homo sapiens)	8 / 12	VAL A1101 PRO A1120 GLU A1171 HIS A1173 PHE A1216 THR A1240 SER A1272 GLY A1274	None None PRO  A1602 ( 4.7A) PRO  A1602 ( 4.5A) PRO  A1602 (-4.3A) 91Y  A1601 (-4.2A) PRO  A1602 (-3.3A) PRO  A1602 (-3.7A)	0.79A	54.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5XIO_A_HFGA801_1 (PROLINE-TRNA SYNTHETASE CLASS II AARS (YBAK RNA BINDING DOMAIN PLUS TRNA SYNTHETASE))	1m54	CYSTATHIONINE BETA-SYNTHASE (Homo sapiens)	3 / 3	THR A  87 GLU A 239 HIS A 232	None	0.89A	22.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5XIO_A_HFGA801_1 (PROLINE-TRNA SYNTHETASE CLASS II AARS (YBAK RNA BINDING DOMAIN PLUS TRNA SYNTHETASE))	1wch	PROTEIN TYROSINE PHOSPHATASE, NON-RECEPTOR TYPE 13 (Homo sapiens)	3 / 3	THR A2309 GLU A2313 HIS A2379	None None PO4  A3478 ( 4.7A)	0.92A	19.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5XIO_A_HFGA801_1 (PROLINE-TRNA SYNTHETASE CLASS II AARS (YBAK RNA BINDING DOMAIN PLUS TRNA SYNTHETASE))	2h03	PROTEIN TYROSINE PHOSPHATASE, RECEPTOR TYPE, B, (Homo sapiens)	3 / 3	THR A1802 GLU A1806 HIS A1871	None None 3UN  A 401 (-3.9A)	0.91A	19.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5XIO_A_HFGA801_1 (PROLINE-TRNA SYNTHETASE CLASS II AARS (YBAK RNA BINDING DOMAIN PLUS TRNA SYNTHETASE))	2i7t	CLEAVAGE AND POLYADENYLATION SPECIFICITY FACTOR 73 KDA SUBUNIT (Homo sapiens)	3 / 3	THR A 206 GLU A 204 HIS A 158	None None ZN  A 482 ( 3.3A)	0.84A	20.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5XIO_A_HFGA801_1 (PROLINE-TRNA SYNTHETASE CLASS II AARS (YBAK RNA BINDING DOMAIN PLUS TRNA SYNTHETASE))	2ooq	RECEPTOR-TYPE TYROSINE-PROTEIN PHOSPHATASE T (Homo sapiens)	3 / 3	THR A1009 GLU A1013 HIS A1075	None	0.93A	19.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5XIO_A_HFGA801_1 (PROLINE-TRNA SYNTHETASE CLASS II AARS (YBAK RNA BINDING DOMAIN PLUS TRNA SYNTHETASE))	2xrc	HUMAN COMPLEMENT FACTOR I (Homo sapiens)	3 / 3	THR A 268 GLU A 270 HIS A 247	None	0.87A	22.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5XIO_A_HFGA801_1 (PROLINE-TRNA SYNTHETASE CLASS II AARS (YBAK RNA BINDING DOMAIN PLUS TRNA SYNTHETASE))	3fe4	CARBONIC ANHYDRASE 6 (Homo sapiens)	3 / 3	THR A 220 GLU A 125 HIS A 111	None MG  A 901 ( 4.4A) MG  A 901 (-3.4A)	0.88A	19.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5XIO_A_HFGA801_1 (PROLINE-TRNA SYNTHETASE CLASS II AARS (YBAK RNA BINDING DOMAIN PLUS TRNA SYNTHETASE))	3zwf	ZINC PHOSPHODIESTERASE ELAC PROTEIN 1 (Homo sapiens)	3 / 3	THR A 277 GLU A 275 HIS A 182	None None ZN  A1364 ( 3.5A)	0.79A	21.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5XIO_A_HFGA801_1 (PROLINE-TRNA SYNTHETASE CLASS II AARS (YBAK RNA BINDING DOMAIN PLUS TRNA SYNTHETASE))	4ye9	GLUTAMINE--TRNA LIGASE (Homo sapiens)	3 / 3	THR A 333 GLU A 449 HIS A 442	None	0.81A	20.03
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	5XIO_A_HFGA801_1 (PROLINE-TRNA SYNTHETASE CLASS II AARS (YBAK RNA BINDING DOMAIN PLUS TRNA SYNTHETASE))	5vad	BIFUNCTIONAL GLUTAMATE/PROLINE--T RNA LIGASE (Homo sapiens)	3 / 3	THR A1121 GLU A1123 HIS A1242	PRO  A1602 (-3.5A) PRO  A1602 (-2.8A) PRO  A1602 (-4.1A)	0.51A	54.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5XIO_B_HFGB802_0 (PROLINE-TRNA SYNTHETASE CLASS II AARS (YBAK RNA BINDING DOMAIN PLUS TRNA SYNTHETASE))	4hxq	ARGINASE-1 (Homo sapiens)	5 / 12	PRO A 247 THR A 246 GLU A 277 HIS A 141 THR A 127	None X8A  A 901 (-3.5A) X8A  A 901 (-4.0A) X8A  A 901 (-3.4A) None	1.32A	20.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5XIO_B_HFGB802_0 (PROLINE-TRNA SYNTHETASE CLASS II AARS (YBAK RNA BINDING DOMAIN PLUS TRNA SYNTHETASE))	5n5n	TUBULIN BETA CHAIN (Homo sapiens)	5 / 12	VAL B 318 THR B 239 PHE B  20 THR B 138 HIS B   6	None	1.49A	21.25
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	5XIO_B_HFGB802_0 (PROLINE-TRNA SYNTHETASE CLASS II AARS (YBAK RNA BINDING DOMAIN PLUS TRNA SYNTHETASE))	5vad	BIFUNCTIONAL GLUTAMATE/PROLINE--T RNA LIGASE (Homo sapiens)	6 / 12	GLU A1100 VAL A1101 ARG A1152 TRP A1169 GLU A1171 THR A1240	None None PRO  A1602 ( 3.4A) None PRO  A1602 ( 4.7A) 91Y  A1601 (-4.2A)	0.82A	54.34
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	5XIO_B_HFGB802_0 (PROLINE-TRNA SYNTHETASE CLASS II AARS (YBAK RNA BINDING DOMAIN PLUS TRNA SYNTHETASE))	5vad	BIFUNCTIONAL GLUTAMATE/PROLINE--T RNA LIGASE (Homo sapiens)	9 / 12	GLU A1154 PRO A1120 THR A1121 ARG A1152 TRP A1169 GLU A1171 HIS A1173 THR A1240 HIS A1242	91Y  A1601 (-4.6A) None PRO  A1602 (-3.5A) PRO  A1602 ( 3.4A) None PRO  A1602 ( 4.7A) PRO  A1602 ( 4.5A) 91Y  A1601 (-4.2A) PRO  A1602 (-4.1A)	0.75A	54.34
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	5XIO_B_HFGB802_0 (PROLINE-TRNA SYNTHETASE CLASS II AARS (YBAK RNA BINDING DOMAIN PLUS TRNA SYNTHETASE))	5vad	BIFUNCTIONAL GLUTAMATE/PROLINE--T RNA LIGASE (Homo sapiens)	7 / 12	GLU A1154 THR A1121 GLU A1171 HIS A1173 PHE A1216 THR A1240 HIS A1242	91Y  A1601 (-4.6A) PRO  A1602 (-3.5A) PRO  A1602 ( 4.7A) PRO  A1602 ( 4.5A) PRO  A1602 (-4.3A) 91Y  A1601 (-4.2A) PRO  A1602 (-4.1A)	0.84A	54.34
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	5XIO_B_HFGB802_0 (PROLINE-TRNA SYNTHETASE CLASS II AARS (YBAK RNA BINDING DOMAIN PLUS TRNA SYNTHETASE))	5vad	BIFUNCTIONAL GLUTAMATE/PROLINE--T RNA LIGASE (Homo sapiens)	5 / 12	PHE A1097 GLU A1154 PHE A1216 THR A1240 HIS A1242	None 91Y  A1601 (-4.6A) PRO  A1602 (-4.3A) 91Y  A1601 (-4.2A) PRO  A1602 (-4.1A)	1.34A	54.34
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	5XIO_B_HFGB802_0 (PROLINE-TRNA SYNTHETASE CLASS II AARS (YBAK RNA BINDING DOMAIN PLUS TRNA SYNTHETASE))	5vad	BIFUNCTIONAL GLUTAMATE/PROLINE--T RNA LIGASE (Homo sapiens)	5 / 12	PHE A1097 VAL A1101 PHE A1216 THR A1240 HIS A1242	None None PRO  A1602 (-4.3A) 91Y  A1601 (-4.2A) PRO  A1602 (-4.1A)	1.38A	54.34
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	5XIO_B_HFGB802_0 (PROLINE-TRNA SYNTHETASE CLASS II AARS (YBAK RNA BINDING DOMAIN PLUS TRNA SYNTHETASE))	5vad	BIFUNCTIONAL GLUTAMATE/PROLINE--T RNA LIGASE (Homo sapiens)	9 / 12	VAL A1101 PRO A1120 THR A1121 ARG A1152 TRP A1169 GLU A1171 HIS A1173 THR A1240 HIS A1242	None None PRO  A1602 (-3.5A) PRO  A1602 ( 3.4A) None PRO  A1602 ( 4.7A) PRO  A1602 ( 4.5A) 91Y  A1601 (-4.2A) PRO  A1602 (-4.1A)	0.59A	54.34
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	5XIO_B_HFGB802_0 (PROLINE-TRNA SYNTHETASE CLASS II AARS (YBAK RNA BINDING DOMAIN PLUS TRNA SYNTHETASE))	5vad	BIFUNCTIONAL GLUTAMATE/PROLINE--T RNA LIGASE (Homo sapiens)	5 / 12	VAL A1101 PRO A1120 THR A1121 GLU A1171 PHE A1248	None None PRO  A1602 (-3.5A) PRO  A1602 ( 4.7A) None	1.29A	54.34
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	5XIO_B_HFGB802_0 (PROLINE-TRNA SYNTHETASE CLASS II AARS (YBAK RNA BINDING DOMAIN PLUS TRNA SYNTHETASE))	5vad	BIFUNCTIONAL GLUTAMATE/PROLINE--T RNA LIGASE (Homo sapiens)	7 / 12	VAL A1101 THR A1121 GLU A1171 HIS A1173 PHE A1216 THR A1240 HIS A1242	None PRO  A1602 (-3.5A) PRO  A1602 ( 4.7A) PRO  A1602 ( 4.5A) PRO  A1602 (-4.3A) 91Y  A1601 (-4.2A) PRO  A1602 (-4.1A)	0.70A	54.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5XIP_A_HFGA1003_0 (PROLYL-TRNA SYNTHETASE, PUTATIVE)	1t77	LIPOPOLYSACCHARIDE-R ESPONSIVE AND BEIGE-LIKE ANCHOR PROTEIN (Homo sapiens)	5 / 12	LEU A2097 VAL A2176 THR A2231 SER A2236 GLY A2234	None	0.96A	20.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5XIP_A_HFGA1003_0 (PROLYL-TRNA SYNTHETASE, PUTATIVE)	2dm4	SORTILIN-RELATED RECEPTOR (Homo sapiens)	5 / 12	LEU A  14 GLU A  46 VAL A  80 THR A  77 GLY A  51	None	1.17A	12.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5XIP_A_HFGA1003_0 (PROLYL-TRNA SYNTHETASE, PUTATIVE)	2pg6	CYTOCHROME P450 2A6 (Homo sapiens)	5 / 12	LEU A 296 PHE A 118 PHE A 480 SER A 213 GLY A 217	None	1.22A	23.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5XIP_A_HFGA1003_0 (PROLYL-TRNA SYNTHETASE, PUTATIVE)	5ao5	C-TYPE MANNOSE RECEPTOR 2 (Homo sapiens)	5 / 12	LEU A 444 PHE A 463 VAL A 461 THR A 305 GLY A 307	None	1.11A	20.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5XIP_A_HFGA1003_0 (PROLYL-TRNA SYNTHETASE, PUTATIVE)	5h1k	GEM-ASSOCIATED PROTEIN 5 (Homo sapiens)	5 / 12	LEU A 375 PHE A  37 VAL A  39 THR A   7 SER A 700	None	1.24A	21.32
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	5XIP_A_HFGA1003_0 (PROLYL-TRNA SYNTHETASE, PUTATIVE)	5vad	BIFUNCTIONAL GLUTAMATE/PROLINE--T RNA LIGASE (Homo sapiens)	5 / 12	GLU A1154 PHE A1216 THR A1240 SER A1272 GLY A1274	91Y  A1601 (-4.6A) PRO  A1602 (-4.3A) 91Y  A1601 (-4.2A) PRO  A1602 (-3.3A) PRO  A1602 (-3.7A)	0.71A	55.94
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	5XIP_A_HFGA1003_0 (PROLYL-TRNA SYNTHETASE, PUTATIVE)	5vad	BIFUNCTIONAL GLUTAMATE/PROLINE--T RNA LIGASE (Homo sapiens)	9 / 12	LEU A1087 GLU A1100 PRO A1120 THR A1121 ARG A1152 HIS A1173 THR A1240 SER A1272 GLY A1274	None None None PRO  A1602 (-3.5A) PRO  A1602 ( 3.4A) PRO  A1602 ( 4.5A) 91Y  A1601 (-4.2A) PRO  A1602 (-3.3A) PRO  A1602 (-3.7A)	0.74A	55.94
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	5XIP_A_HFGA1003_0 (PROLYL-TRNA SYNTHETASE, PUTATIVE)	5vad	BIFUNCTIONAL GLUTAMATE/PROLINE--T RNA LIGASE (Homo sapiens)	6 / 12	LEU A1087 GLU A1100 VAL A1101 PRO A1120 HIS A1173 THR A1222	None None None None PRO  A1602 ( 4.5A) None	1.48A	55.94
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	5XIP_A_HFGA1003_0 (PROLYL-TRNA SYNTHETASE, PUTATIVE)	5vad	BIFUNCTIONAL GLUTAMATE/PROLINE--T RNA LIGASE (Homo sapiens)	9 / 12	LEU A1087 GLU A1100 VAL A1101 PRO A1120 THR A1121 ARG A1152 HIS A1173 THR A1240 GLY A1274	None None None None PRO  A1602 (-3.5A) PRO  A1602 ( 3.4A) PRO  A1602 ( 4.5A) 91Y  A1601 (-4.2A) PRO  A1602 (-3.7A)	0.71A	55.94
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	5XIP_A_HFGA1003_0 (PROLYL-TRNA SYNTHETASE, PUTATIVE)	5vad	BIFUNCTIONAL GLUTAMATE/PROLINE--T RNA LIGASE (Homo sapiens)	8 / 12	LEU A1087 PRO A1120 THR A1121 HIS A1173 PHE A1216 THR A1240 SER A1272 GLY A1274	None None PRO  A1602 (-3.5A) PRO  A1602 ( 4.5A) PRO  A1602 (-4.3A) 91Y  A1601 (-4.2A) PRO  A1602 (-3.3A) PRO  A1602 (-3.7A)	0.72A	55.94
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	5XIP_A_HFGA1003_0 (PROLYL-TRNA SYNTHETASE, PUTATIVE)	5vad	BIFUNCTIONAL GLUTAMATE/PROLINE--T RNA LIGASE (Homo sapiens)	5 / 12	VAL A1101 PRO A1120 THR A1121 HIS A1173 PHE A1248	None None PRO  A1602 (-3.5A) PRO  A1602 ( 4.5A) None	1.25A	55.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5XIP_A_HFGA1003_0 (PROLYL-TRNA SYNTHETASE, PUTATIVE)	6bf6	INSULIN-DEGRADING ENZYME (Homo sapiens)	5 / 12	LEU A 823 GLU A 864 PHE A 811 THR A 797 GLY A 845	None	1.29A	undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5XIP_A_HFGA1003_1 (PROLYL-TRNA SYNTHETASE, PUTATIVE)	1b41	ACETYLCHOLINESTERASE (Homo sapiens)	3 / 3	GLU A 450 TRP A 117 HIS A 447	None	0.89A	21.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5XIP_A_HFGA1003_1 (PROLYL-TRNA SYNTHETASE, PUTATIVE)	1jd0	CARBONIC ANHYDRASE XII (Homo sapiens)	3 / 3	GLU A 106 TRP A 209 HIS A  94	ZN  A 901 ( 4.5A) None ZN  A 901 ( 3.2A)	1.03A	20.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5XIP_A_HFGA1003_1 (PROLYL-TRNA SYNTHETASE, PUTATIVE)	1jd0	CARBONIC ANHYDRASE XII (Homo sapiens)	3 / 3	GLU A 117 TRP A 209 HIS A  94	None None ZN  A 901 ( 3.2A)	1.12A	20.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5XIP_A_HFGA1003_1 (PROLYL-TRNA SYNTHETASE, PUTATIVE)	2it4	CARBONIC ANHYDRASE 1 (Homo sapiens)	3 / 3	GLU A 106 TRP A 209 HIS A  94	ZN  A 561 ( 4.9A) None ZN  A 561 ( 3.2A)	1.07A	18.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5XIP_A_HFGA1003_1 (PROLYL-TRNA SYNTHETASE, PUTATIVE)	2rgn	RHO GUANINE NUCLEOTIDE EXCHANGE FACTOR 25 (Homo sapiens)	3 / 3	GLU B 224 TRP B 234 HIS B 242	None	1.08A	21.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5XIP_A_HFGA1003_1 (PROLYL-TRNA SYNTHETASE, PUTATIVE)	3da2	CARBONIC ANHYDRASE 13 (Homo sapiens)	3 / 3	GLU A 107 TRP A 210 HIS A  95	ZN  A 301 ( 4.9A) None ZN  A 301 ( 3.6A)	1.12A	17.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5XIP_A_HFGA1003_1 (PROLYL-TRNA SYNTHETASE, PUTATIVE)	3fe4	CARBONIC ANHYDRASE 6 (Homo sapiens)	3 / 3	GLU A 125 TRP A 230 HIS A 111	MG  A 901 ( 4.4A) None MG  A 901 (-3.4A)	0.87A	21.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5XIP_A_HFGA1003_1 (PROLYL-TRNA SYNTHETASE, PUTATIVE)	3fe4	CARBONIC ANHYDRASE 6 (Homo sapiens)	3 / 3	GLU A 136 TRP A 230 HIS A 111	None None MG  A 901 (-3.4A)	0.95A	21.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5XIP_A_HFGA1003_1 (PROLYL-TRNA SYNTHETASE, PUTATIVE)	3k9b	LIVER CARBOXYLESTERASE 1 (Homo sapiens)	3 / 3	GLU A1471 TRP A1138 HIS A1468	None	1.07A	21.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5XIP_A_HFGA1003_1 (PROLYL-TRNA SYNTHETASE, PUTATIVE)	3ml5	CARBONIC ANHYDRASE 7 (Homo sapiens)	3 / 3	GLU A 106 TRP A 209 HIS A  94	ZN  A 263 ( 4.6A) None ZN  A 263 ( 3.2A)	1.09A	18.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5XIP_A_HFGA1003_1 (PROLYL-TRNA SYNTHETASE, PUTATIVE)	3uyq	CARBONIC ANHYDRASE 3 (Homo sapiens)	3 / 3	GLU A 106 TRP A 208 HIS A  94	ZN  A 261 ( 4.9A) None ZN  A 261 (-3.3A)	0.93A	19.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5XIP_A_HFGA1003_1 (PROLYL-TRNA SYNTHETASE, PUTATIVE)	3uyq	CARBONIC ANHYDRASE 3 (Homo sapiens)	3 / 3	GLU A 117 TRP A 208 HIS A  94	None None ZN  A 261 (-3.3A)	1.07A	19.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5XIP_A_HFGA1003_1 (PROLYL-TRNA SYNTHETASE, PUTATIVE)	4qk3	CARBONIC ANHYDRASE 2 (Homo sapiens)	3 / 3	GLU A 106 TRP A 209 HIS A  94	ZN  A 301 ( 4.5A) None ZN  A 301 (-3.2A)	1.07A	19.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5XIP_A_HFGA1003_1 (PROLYL-TRNA SYNTHETASE, PUTATIVE)	4xii	CHOLINESTERASE (Homo sapiens)	3 / 3	GLU A 441 TRP A 112 HIS A 438	None None 40V  A1001 (-3.6A)	0.87A	19.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5XIP_A_HFGA1003_1 (PROLYL-TRNA SYNTHETASE, PUTATIVE)	5jn9	CARBONIC ANHYDRASE 4 (Homo sapiens)	3 / 3	GLU A 106 TRP A 209 HIS A  94	ZN  A 301 ( 4.6A) None ZN  A 301 ( 3.3A)	0.97A	20.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5XIP_A_HFGA1003_1 (PROLYL-TRNA SYNTHETASE, PUTATIVE)	5jn9	CARBONIC ANHYDRASE 4 (Homo sapiens)	3 / 3	GLU A 117 TRP A 209 HIS A  94	None None ZN  A 301 ( 3.3A)	1.11A	20.36
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	5XIP_A_HFGA1003_1 (PROLYL-TRNA SYNTHETASE, PUTATIVE)	5vad	BIFUNCTIONAL GLUTAMATE/PROLINE--T RNA LIGASE (Homo sapiens)	3 / 3	GLU A1123 TRP A1169 HIS A1242	PRO  A1602 (-2.8A) None PRO  A1602 (-4.1A)	0.42A	55.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5XIP_B_HFGB1003_0 (PROLYL-TRNA SYNTHETASE, PUTATIVE)	4bgq	CYCLIN-DEPENDENT KINASE-LIKE 5 (Homo sapiens)	5 / 12	VAL A  73 GLU A  77 PHE A  13 THR A  35 HIS A  32	None	1.48A	21.61
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	5XIP_B_HFGB1003_0 (PROLYL-TRNA SYNTHETASE, PUTATIVE)	5vad	BIFUNCTIONAL GLUTAMATE/PROLINE--T RNA LIGASE (Homo sapiens)	9 / 12	GLU A1100 VAL A1101 PRO A1120 THR A1121 GLU A1123 ARG A1152 TRP A1169 HIS A1173 THR A1240	None None None PRO  A1602 (-3.5A) PRO  A1602 (-2.8A) PRO  A1602 ( 3.4A) None PRO  A1602 ( 4.5A) 91Y  A1601 (-4.2A)	0.67A	55.94
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	5XIP_B_HFGB1003_0 (PROLYL-TRNA SYNTHETASE, PUTATIVE)	5vad	BIFUNCTIONAL GLUTAMATE/PROLINE--T RNA LIGASE (Homo sapiens)	7 / 12	GLU A1100 VAL A1101 PRO A1120 THR A1121 GLU A1123 HIS A1173 THR A1222	None None None PRO  A1602 (-3.5A) PRO  A1602 (-2.8A) PRO  A1602 ( 4.5A) None	1.10A	55.94
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	5XIP_B_HFGB1003_0 (PROLYL-TRNA SYNTHETASE, PUTATIVE)	5vad	BIFUNCTIONAL GLUTAMATE/PROLINE--T RNA LIGASE (Homo sapiens)	7 / 12	GLU A1154 THR A1121 ARG A1152 TRP A1169 HIS A1173 THR A1240 HIS A1242	91Y  A1601 (-4.6A) PRO  A1602 (-3.5A) PRO  A1602 ( 3.4A) None PRO  A1602 ( 4.5A) 91Y  A1601 (-4.2A) PRO  A1602 (-4.1A)	0.91A	55.94
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	5XIP_B_HFGB1003_0 (PROLYL-TRNA SYNTHETASE, PUTATIVE)	5vad	BIFUNCTIONAL GLUTAMATE/PROLINE--T RNA LIGASE (Homo sapiens)	6 / 12	GLU A1154 TRP A1169 HIS A1173 PHE A1216 THR A1240 HIS A1242	91Y  A1601 (-4.6A) None PRO  A1602 ( 4.5A) PRO  A1602 (-4.3A) 91Y  A1601 (-4.2A) PRO  A1602 (-4.1A)	0.91A	55.94
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	5XIP_B_HFGB1003_0 (PROLYL-TRNA SYNTHETASE, PUTATIVE)	5vad	BIFUNCTIONAL GLUTAMATE/PROLINE--T RNA LIGASE (Homo sapiens)	7 / 12	PRO A1120 GLU A1123 TRP A1169 HIS A1173 PHE A1216 THR A1240 HIS A1242	None PRO  A1602 (-2.8A) None PRO  A1602 ( 4.5A) PRO  A1602 (-4.3A) 91Y  A1601 (-4.2A) PRO  A1602 (-4.1A)	0.64A	55.94
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	5XIP_B_HFGB1003_0 (PROLYL-TRNA SYNTHETASE, PUTATIVE)	5vad	BIFUNCTIONAL GLUTAMATE/PROLINE--T RNA LIGASE (Homo sapiens)	9 / 12	VAL A1101 PRO A1120 THR A1121 GLU A1123 ARG A1152 TRP A1169 HIS A1173 THR A1240 HIS A1242	None None PRO  A1602 (-3.5A) PRO  A1602 (-2.8A) PRO  A1602 ( 3.4A) None PRO  A1602 ( 4.5A) 91Y  A1601 (-4.2A) PRO  A1602 (-4.1A)	0.58A	55.94
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	5XIP_B_HFGB1003_0 (PROLYL-TRNA SYNTHETASE, PUTATIVE)	5vad	BIFUNCTIONAL GLUTAMATE/PROLINE--T RNA LIGASE (Homo sapiens)	5 / 12	VAL A1101 PRO A1120 THR A1121 HIS A1173 PHE A1248	None None PRO  A1602 (-3.5A) PRO  A1602 ( 4.5A) None	1.24A	55.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5XIP_C_HFGC1003_0 (PROLYL-TRNA SYNTHETASE, PUTATIVE)	2r3v	MEVALONATE KINASE (Homo sapiens)	5 / 12	LEU A 153 VAL A 133 GLU A 193 HIS A 197 GLY A 142	None	1.28A	21.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5XIP_C_HFGC1003_0 (PROLYL-TRNA SYNTHETASE, PUTATIVE)	5l7d	SMOOTHENED HOMOLOG,SOLUBLE CYTOCHROME B562,SMOOTHENED HOMOLOG (Escherichia coli; Homo sapiens)	5 / 12	LEU A 146 VAL A 182 PRO A 124 TRP A 119 GLY A 111	None None None None CLR  A1203 (-4.0A)	1.26A	21.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5XIP_C_HFGC1003_0 (PROLYL-TRNA SYNTHETASE, PUTATIVE)	5la7	HEPARANASE (Homo sapiens)	5 / 12	GLU A 154 GLU A 343 GLU A 225 HIS A 296 GLY A 223	EDO  A 612 ( 4.5A) 6S6  A 613 (-1.9A) 6S6  A 613 (-3.4A) None None	1.13A	20.64
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	5XIP_C_HFGC1003_0 (PROLYL-TRNA SYNTHETASE, PUTATIVE)	5vad	BIFUNCTIONAL GLUTAMATE/PROLINE--T RNA LIGASE (Homo sapiens)	7 / 12	LEU A1087 GLU A1100 VAL A1101 PRO A1120 GLU A1123 HIS A1173 THR A1222	None None None None PRO  A1602 (-2.8A) PRO  A1602 ( 4.5A) None	1.40A	55.94
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	5XIP_C_HFGC1003_0 (PROLYL-TRNA SYNTHETASE, PUTATIVE)	5vad	BIFUNCTIONAL GLUTAMATE/PROLINE--T RNA LIGASE (Homo sapiens)	11 / 12	LEU A1087 GLU A1100 VAL A1101 PRO A1120 THR A1121 GLU A1123 TRP A1169 GLU A1171 HIS A1173 THR A1240 GLY A1274	None None None None PRO  A1602 (-3.5A) PRO  A1602 (-2.8A) None PRO  A1602 ( 4.7A) PRO  A1602 ( 4.5A) 91Y  A1601 (-4.2A) PRO  A1602 (-3.7A)	0.64A	55.94
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	5XIP_C_HFGC1003_0 (PROLYL-TRNA SYNTHETASE, PUTATIVE)	5vad	BIFUNCTIONAL GLUTAMATE/PROLINE--T RNA LIGASE (Homo sapiens)	11 / 12	LEU A1087 VAL A1101 PRO A1120 THR A1121 GLU A1123 TRP A1169 GLU A1171 HIS A1173 PHE A1216 THR A1240 GLY A1274	None None None PRO  A1602 (-3.5A) PRO  A1602 (-2.8A) None PRO  A1602 ( 4.7A) PRO  A1602 ( 4.5A) PRO  A1602 (-4.3A) 91Y  A1601 (-4.2A) PRO  A1602 (-3.7A)	0.63A	55.94
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	5XIP_C_HFGC1003_0 (PROLYL-TRNA SYNTHETASE, PUTATIVE)	5vad	BIFUNCTIONAL GLUTAMATE/PROLINE--T RNA LIGASE (Homo sapiens)	5 / 12	VAL A1101 PRO A1120 THR A1121 GLU A1171 PHE A1248	None None PRO  A1602 (-3.5A) PRO  A1602 ( 4.7A) None	1.23A	55.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5XIP_C_HFGC1003_0 (PROLYL-TRNA SYNTHETASE, PUTATIVE)	6bf6	INSULIN-DEGRADING ENZYME (Homo sapiens)	5 / 12	LEU A 823 GLU A 864 PHE A 811 THR A 797 GLY A 845	None	1.28A	undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5XIP_D_HFGD1003_0 (PROLYL-TRNA SYNTHETASE, PUTATIVE)	3wtd	UNCHARACTERIZED PROTEIN C9ORF142 (Homo sapiens)	5 / 12	LEU A  98 GLU A  81 THR A  73 ARG A  77 GLU A  27	None	1.30A	15.46
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	5XIP_D_HFGD1003_0 (PROLYL-TRNA SYNTHETASE, PUTATIVE)	5vad	BIFUNCTIONAL GLUTAMATE/PROLINE--T RNA LIGASE (Homo sapiens)	11 / 12	LEU A1087 GLU A1100 VAL A1101 PRO A1120 THR A1121 GLU A1123 ARG A1152 TRP A1169 GLU A1171 THR A1240 TRP A1273	None None None None PRO  A1602 (-3.5A) PRO  A1602 (-2.8A) PRO  A1602 ( 3.4A) None PRO  A1602 ( 4.7A) 91Y  A1601 (-4.2A) None	0.73A	55.94
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	5XIP_D_HFGD1003_0 (PROLYL-TRNA SYNTHETASE, PUTATIVE)	5vad	BIFUNCTIONAL GLUTAMATE/PROLINE--T RNA LIGASE (Homo sapiens)	7 / 12	LEU A1087 GLU A1100 VAL A1101 PRO A1120 THR A1121 GLU A1123 THR A1222	None None None None PRO  A1602 (-3.5A) PRO  A1602 (-2.8A) None	1.36A	55.94
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	5XIP_D_HFGD1003_0 (PROLYL-TRNA SYNTHETASE, PUTATIVE)	5vad	BIFUNCTIONAL GLUTAMATE/PROLINE--T RNA LIGASE (Homo sapiens)	10 / 12	LEU A1087 VAL A1101 PRO A1120 GLU A1123 ARG A1152 TRP A1169 GLU A1171 PHE A1216 THR A1240 TRP A1273	None None None PRO  A1602 (-2.8A) PRO  A1602 ( 3.4A) None PRO  A1602 ( 4.7A) PRO  A1602 (-4.3A) 91Y  A1601 (-4.2A) None	0.71A	55.94
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	5XIP_D_HFGD1003_0 (PROLYL-TRNA SYNTHETASE, PUTATIVE)	5vad	BIFUNCTIONAL GLUTAMATE/PROLINE--T RNA LIGASE (Homo sapiens)	6 / 12	VAL A1101 PRO A1120 THR A1121 GLU A1171 PHE A1248 TRP A1273	None None PRO  A1602 (-3.5A) PRO  A1602 ( 4.7A) None None	1.42A	55.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5XIQ_A_HFGA1002_0 (PROLYL-TRNA SYNTHETASE (PRORS))	1srq	GTPASE-ACTIVATING PROTEIN 1 (Homo sapiens)	5 / 12	LEU A 365 VAL A 334 PHE A 220 THR A 213 SER A 269	None	1.32A	22.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5XIQ_A_HFGA1002_0 (PROLYL-TRNA SYNTHETASE (PRORS))	1t77	LIPOPOLYSACCHARIDE-R ESPONSIVE AND BEIGE-LIKE ANCHOR PROTEIN (Homo sapiens)	5 / 12	LEU A2097 VAL A2176 THR A2231 SER A2236 GLY A2234	None	0.92A	20.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5XIQ_A_HFGA1002_0 (PROLYL-TRNA SYNTHETASE (PRORS))	1zlt	SERINE/THREONINE-PRO TEIN KINASE CHK1 (Homo sapiens)	5 / 12	LEU A  82 VAL A  40 HIS A 128 THR A 170 GLY A 169	None	1.30A	20.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5XIQ_A_HFGA1002_0 (PROLYL-TRNA SYNTHETASE (PRORS))	3gym	PROSTASIN (Homo sapiens)	5 / 12	LEU A 171 VAL A 184 PRO A 225 THR A 210 GLY A 211	None	1.09A	17.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5XIQ_A_HFGA1002_0 (PROLYL-TRNA SYNTHETASE (PRORS))	3nks	PROTOPORPHYRINOGEN OXIDASE (Homo sapiens)	5 / 12	LEU A 233 VAL A 456 PRO A  58 PHE A 331 GLY A 345	None FAD  A 479 (-4.0A) FAD  A 479 (-3.9A) ACJ  A 478 (-4.6A) ACJ  A 478 (-3.6A)	1.33A	23.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5XIQ_A_HFGA1002_0 (PROLYL-TRNA SYNTHETASE (PRORS))	3o2x	COLLAGENASE 3 (Homo sapiens)	5 / 12	LEU A1239 PHE A1224 VAL A1144 PHE A1201 THR A1126	3O2  A1801 (-4.5A) None None None None	1.30A	16.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5XIQ_A_HFGA1002_0 (PROLYL-TRNA SYNTHETASE (PRORS))	3zyx	AMINE OXIDASE [FLAVIN-CONTAINING] B (Homo sapiens)	5 / 12	LEU A 414 VAL A 289 PRO A 266 THR A  43 GLY A  41	None None None FAD  A 600 (-4.0A) FAD  A 600 (-3.2A)	1.25A	21.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5XIQ_A_HFGA1002_0 (PROLYL-TRNA SYNTHETASE (PRORS))	4fvl	COLLAGENASE 3 (Homo sapiens)	5 / 12	LEU A 239 PHE A 224 VAL A 144 PHE A 201 THR A 126	None	1.28A	20.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5XIQ_A_HFGA1002_0 (PROLYL-TRNA SYNTHETASE (PRORS))	4gs4	ALPHA-TUBULIN N-ACETYLTRANSFERASE (Homo sapiens)	5 / 12	LEU A 164 VAL A 184 PRO A 159 THR A  65 SER A  54	None	1.29A	17.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5XIQ_A_HFGA1002_0 (PROLYL-TRNA SYNTHETASE (PRORS))	4if5	ALPHA-TUBULIN N-ACETYLTRANSFERASE (Homo sapiens)	5 / 12	LEU A 164 VAL A 184 PRO A 159 THR A  65 SER A  54	None None None CL  A 202 (-4.0A) None	1.25A	17.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5XIQ_A_HFGA1002_0 (PROLYL-TRNA SYNTHETASE (PRORS))	5ao5	C-TYPE MANNOSE RECEPTOR 2 (Homo sapiens)	5 / 12	LEU A 444 PHE A 463 VAL A 461 THR A 305 GLY A 307	None	1.08A	19.36
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	5XIQ_A_HFGA1002_0 (PROLYL-TRNA SYNTHETASE (PRORS))	5vad	BIFUNCTIONAL GLUTAMATE/PROLINE--T RNA LIGASE (Homo sapiens)	5 / 12	GLU A1154 PHE A1216 THR A1240 SER A1272 GLY A1274	91Y  A1601 (-4.6A) PRO  A1602 (-4.3A) 91Y  A1601 (-4.2A) PRO  A1602 (-3.3A) PRO  A1602 (-3.7A)	0.84A	55.43
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	5XIQ_A_HFGA1002_0 (PROLYL-TRNA SYNTHETASE (PRORS))	5vad	BIFUNCTIONAL GLUTAMATE/PROLINE--T RNA LIGASE (Homo sapiens)	8 / 12	LEU A1087 GLU A1100 VAL A1101 TRP A1169 GLU A1171 HIS A1173 THR A1240 GLY A1274	None None None None PRO  A1602 ( 4.7A) PRO  A1602 ( 4.5A) 91Y  A1601 (-4.2A) PRO  A1602 (-3.7A)	0.74A	55.43
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	5XIQ_A_HFGA1002_0 (PROLYL-TRNA SYNTHETASE (PRORS))	5vad	BIFUNCTIONAL GLUTAMATE/PROLINE--T RNA LIGASE (Homo sapiens)	9 / 12	LEU A1087 VAL A1101 PRO A1120 TRP A1169 GLU A1171 HIS A1173 THR A1240 SER A1272 GLY A1274	None None None None PRO  A1602 ( 4.7A) PRO  A1602 ( 4.5A) 91Y  A1601 (-4.2A) PRO  A1602 (-3.3A) PRO  A1602 (-3.7A)	0.58A	55.43
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	5XIQ_A_HFGA1002_0 (PROLYL-TRNA SYNTHETASE (PRORS))	5vad	BIFUNCTIONAL GLUTAMATE/PROLINE--T RNA LIGASE (Homo sapiens)	9 / 12	LEU A1087 VAL A1101 TRP A1169 GLU A1171 HIS A1173 PHE A1216 THR A1240 SER A1272 GLY A1274	None None None PRO  A1602 ( 4.7A) PRO  A1602 ( 4.5A) PRO  A1602 (-4.3A) 91Y  A1601 (-4.2A) PRO  A1602 (-3.3A) PRO  A1602 (-3.7A)	0.72A	55.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5XIQ_A_HFGA1002_0 (PROLYL-TRNA SYNTHETASE (PRORS))	6bf6	INSULIN-DEGRADING ENZYME (Homo sapiens)	5 / 12	LEU A 823 GLU A 864 PHE A 811 THR A 797 GLY A 845	None	1.28A	undetectable
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	5XIQ_A_HFGA1002_1 (PROLYL-TRNA SYNTHETASE (PRORS))	5vad	BIFUNCTIONAL GLUTAMATE/PROLINE--T RNA LIGASE (Homo sapiens)	4 / 4	THR A1121 GLU A1123 ARG A1152 HIS A1242	PRO  A1602 (-3.5A) PRO  A1602 (-2.8A) PRO  A1602 ( 3.4A) PRO  A1602 (-4.1A)	0.59A	55.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5XIQ_B_HFGB1002_0 (PROLYL-TRNA SYNTHETASE (PRORS))	1srq	GTPASE-ACTIVATING PROTEIN 1 (Homo sapiens)	5 / 12	LEU A 365 VAL A 334 PHE A 220 THR A 213 SER A 269	None	1.31A	22.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5XIQ_B_HFGB1002_0 (PROLYL-TRNA SYNTHETASE (PRORS))	4gs4	ALPHA-TUBULIN N-ACETYLTRANSFERASE (Homo sapiens)	5 / 12	LEU A 164 VAL A 184 PRO A 159 THR A  65 SER A  54	None	1.34A	17.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5XIQ_B_HFGB1002_0 (PROLYL-TRNA SYNTHETASE (PRORS))	4if5	ALPHA-TUBULIN N-ACETYLTRANSFERASE (Homo sapiens)	5 / 12	LEU A 164 VAL A 184 PRO A 159 THR A  65 SER A  54	None None None CL  A 202 (-4.0A) None	1.30A	17.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5XIQ_B_HFGB1002_0 (PROLYL-TRNA SYNTHETASE (PRORS))	4kvn	HUMAN IGG HEAVY CHAIN (Homo sapiens)	5 / 12	LEU H  86 VAL H  12 PRO H  18 THR H  78 SER H  71	None	1.39A	17.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	5XIQ_B_HFGB1002_0 (PROLYL-TRNA SYNTHETASE (PRORS))	5vad	BIFUNCTIONAL GLUTAMATE/PROLINE--T RNA LIGASE (Homo sapiens)	8 / 12	LEU A1087 GLU A1100 VAL A1101 ARG A1152 TRP A1169 GLU A1171 HIS A1173 THR A1240	None None None PRO  A1602 ( 3.4A) None PRO  A1602 ( 4.7A) PRO  A1602 ( 4.5A) 91Y  A1601 (-4.2A)	0.78A	55.43
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	5XIQ_B_HFGB1002_0 (PROLYL-TRNA SYNTHETASE (PRORS))	5vad	BIFUNCTIONAL GLUTAMATE/PROLINE--T RNA LIGASE (Homo sapiens)	9 / 12	LEU A1087 VAL A1101 PRO A1120 ARG A1152 TRP A1169 GLU A1171 HIS A1173 THR A1240 SER A1272	None None None PRO  A1602 ( 3.4A) None PRO  A1602 ( 4.7A) PRO  A1602 ( 4.5A) 91Y  A1601 (-4.2A) PRO  A1602 (-3.3A)	0.59A	55.43
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	5XIQ_B_HFGB1002_0 (PROLYL-TRNA SYNTHETASE (PRORS))	5vad	BIFUNCTIONAL GLUTAMATE/PROLINE--T RNA LIGASE (Homo sapiens)	6 / 12	LEU A1087 VAL A1101 PRO A1120 HIS A1173 THR A1222 SER A1272	None None None PRO  A1602 ( 4.5A) None PRO  A1602 (-3.3A)	1.44A	55.43
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	5XIQ_B_HFGB1002_0 (PROLYL-TRNA SYNTHETASE (PRORS))	5vad	BIFUNCTIONAL GLUTAMATE/PROLINE--T RNA LIGASE (Homo sapiens)	9 / 12	LEU A1087 VAL A1101 PRO A1120 TRP A1169 GLU A1171 HIS A1173 PHE A1216 THR A1240 SER A1272	None None None None PRO  A1602 ( 4.7A) PRO  A1602 ( 4.5A) PRO  A1602 (-4.3A) 91Y  A1601 (-4.2A) PRO  A1602 (-3.3A)	0.73A	55.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5XIQ_B_HFGB1002_1 (PROLYL-TRNA SYNTHETASE (PRORS))	1m54	CYSTATHIONINE BETA-SYNTHASE (Homo sapiens)	3 / 3	THR A  87 GLU A 239 HIS A 232	None	0.89A	21.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5XIQ_B_HFGB1002_1 (PROLYL-TRNA SYNTHETASE (PRORS))	2i7t	CLEAVAGE AND POLYADENYLATION SPECIFICITY FACTOR 73 KDA SUBUNIT (Homo sapiens)	3 / 3	THR A 206 GLU A 204 HIS A 158	None None ZN  A 482 ( 3.3A)	0.84A	21.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5XIQ_B_HFGB1002_1 (PROLYL-TRNA SYNTHETASE (PRORS))	2xrc	HUMAN COMPLEMENT FACTOR I (Homo sapiens)	3 / 3	THR A 268 GLU A 270 HIS A 247	None	0.87A	22.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5XIQ_B_HFGB1002_1 (PROLYL-TRNA SYNTHETASE (PRORS))	3fe4	CARBONIC ANHYDRASE 6 (Homo sapiens)	3 / 3	THR A 220 GLU A 125 HIS A 111	None MG  A 901 ( 4.4A) MG  A 901 (-3.4A)	0.83A	20.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5XIQ_B_HFGB1002_1 (PROLYL-TRNA SYNTHETASE (PRORS))	3zwf	ZINC PHOSPHODIESTERASE ELAC PROTEIN 1 (Homo sapiens)	3 / 3	THR A 277 GLU A 275 HIS A 182	None None ZN  A1364 ( 3.5A)	0.82A	22.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5XIQ_B_HFGB1002_1 (PROLYL-TRNA SYNTHETASE (PRORS))	4ye9	GLUTAMINE--TRNA LIGASE (Homo sapiens)	3 / 3	THR A 333 GLU A 449 HIS A 442	None	0.78A	21.74
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	5XIQ_B_HFGB1002_1 (PROLYL-TRNA SYNTHETASE (PRORS))	5vad	BIFUNCTIONAL GLUTAMATE/PROLINE--T RNA LIGASE (Homo sapiens)	3 / 3	THR A1121 GLU A1123 HIS A1242	PRO  A1602 (-3.5A) PRO  A1602 (-2.8A) PRO  A1602 (-4.1A)	0.48A	55.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5XIQ_C_HFGC1002_0 (PROLYL-TRNA SYNTHETASE (PRORS))	2f57	SERINE/THREONINE-PRO TEIN KINASE PAK 7 (Homo sapiens)	5 / 12	PRO A 607 THR A 606 TRP A 609 THR A 532 SER A 573	None TRS  A 802 ( 4.9A) None None TRS  A 802 ( 4.9A)	1.16A	22.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5XIQ_C_HFGC1002_0 (PROLYL-TRNA SYNTHETASE (PRORS))	4fie	SERINE/THREONINE-PRO TEIN KINASE PAK 4 (Homo sapiens)	5 / 12	PRO A 479 THR A 478 TRP A 481 THR A 404 SER A 445	None	1.34A	22.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5XIQ_C_HFGC1002_0 (PROLYL-TRNA SYNTHETASE (PRORS))	4ks8	SERINE/THREONINE-PRO TEIN KINASE PAK 6 (Homo sapiens)	5 / 12	PRO A 565 THR A 564 TRP A 567 THR A 490 SER A 531	None	1.28A	21.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5XIQ_C_HFGC1002_0 (PROLYL-TRNA SYNTHETASE (PRORS))	4xbr	PROTEIN FAM212A,SERINE/THREO NINE-PROTEIN KINASE PAK 4 (Homo sapiens)	5 / 12	PRO A 479 THR A 478 TRP A 481 THR A 404 SER A 445	None None None None MG  A 603 ( 4.0A)	1.24A	22.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5XIQ_C_HFGC1002_0 (PROLYL-TRNA SYNTHETASE (PRORS))	5dot	CARBAMOYL-PHOSPHATE SYNTHASE [AMMONIA], MITOCHONDRIAL (Homo sapiens)	5 / 12	PHE A1266 GLU A1334 VAL A1335 THR A1207 GLU A1197	None	1.48A	16.60
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	5XIQ_C_HFGC1002_0 (PROLYL-TRNA SYNTHETASE (PRORS))	5vad	BIFUNCTIONAL GLUTAMATE/PROLINE--T RNA LIGASE (Homo sapiens)	7 / 12	GLU A1100 VAL A1101 PRO A1120 THR A1121 ARG A1152 THR A1222 SER A1272	None None None PRO  A1602 (-3.5A) PRO  A1602 ( 3.4A) None PRO  A1602 (-3.3A)	1.41A	55.43
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	5XIQ_C_HFGC1002_0 (PROLYL-TRNA SYNTHETASE (PRORS))	5vad	BIFUNCTIONAL GLUTAMATE/PROLINE--T RNA LIGASE (Homo sapiens)	10 / 12	GLU A1100 VAL A1101 PRO A1120 THR A1121 ARG A1152 TRP A1169 GLU A1171 HIS A1173 THR A1240 SER A1272	None None None PRO  A1602 (-3.5A) PRO  A1602 ( 3.4A) None PRO  A1602 ( 4.7A) PRO  A1602 ( 4.5A) 91Y  A1601 (-4.2A) PRO  A1602 (-3.3A)	0.77A	55.43
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	5XIQ_C_HFGC1002_0 (PROLYL-TRNA SYNTHETASE (PRORS))	5vad	BIFUNCTIONAL GLUTAMATE/PROLINE--T RNA LIGASE (Homo sapiens)	10 / 12	GLU A1100 VAL A1101 PRO A1120 THR A1121 TRP A1169 GLU A1171 HIS A1173 PHE A1216 THR A1240 SER A1272	None None None PRO  A1602 (-3.5A) None PRO  A1602 ( 4.7A) PRO  A1602 ( 4.5A) PRO  A1602 (-4.3A) 91Y  A1601 (-4.2A) PRO  A1602 (-3.3A)	0.88A	55.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5XIQ_C_HFGC1002_0 (PROLYL-TRNA SYNTHETASE (PRORS))	5vef	SERINE/THREONINE-PRO TEIN KINASE PAK 4 (Homo sapiens)	5 / 12	PRO A 479 THR A 478 TRP A 481 THR A 404 SER A 445	None None None ACT  A 602 (-3.3A) None	1.22A	22.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5XIQ_D_HFGD1002_0 (PROLYL-TRNA SYNTHETASE (PRORS))	1zlt	SERINE/THREONINE-PRO TEIN KINASE CHK1 (Homo sapiens)	5 / 12	LEU A  82 VAL A  40 HIS A 128 THR A 170 GLY A 169	None	1.32A	20.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5XIQ_D_HFGD1002_0 (PROLYL-TRNA SYNTHETASE (PRORS))	2vr2	DIHYDROPYRIMIDINASE (Homo sapiens)	5 / 12	LEU A 311 VAL A 249 PRO A 272 THR A  95 GLY A  63	None	1.36A	19.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5XIQ_D_HFGD1002_0 (PROLYL-TRNA SYNTHETASE (PRORS))	4fvl	COLLAGENASE 3 (Homo sapiens)	5 / 12	LEU A 239 PHE A 224 VAL A 144 PHE A 201 THR A 126	None	1.31A	20.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5XIQ_D_HFGD1002_0 (PROLYL-TRNA SYNTHETASE (PRORS))	4qei	GLYCINE--TRNA LIGASE (Homo sapiens)	5 / 12	LEU A 135 PHE A 144 ARG A 277 GLU A 296 GLY A 406	None None AMP  A 701 (-2.9A) None AMP  A 701 (-4.0A)	1.22A	24.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5XIQ_D_HFGD1002_0 (PROLYL-TRNA SYNTHETASE (PRORS))	4qei	GLYCINE--TRNA LIGASE (Homo sapiens)	5 / 12	LEU A 135 PRO A 244 ARG A 277 GLU A 296 GLY A 406	None None AMP  A 701 (-2.9A) None AMP  A 701 (-4.0A)	1.00A	24.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5XIQ_D_HFGD1002_0 (PROLYL-TRNA SYNTHETASE (PRORS))	5ao5	C-TYPE MANNOSE RECEPTOR 2 (Homo sapiens)	5 / 12	LEU A 444 PHE A 463 VAL A 461 THR A 305 GLY A 307	None	1.10A	19.36
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	5XIQ_D_HFGD1002_0 (PROLYL-TRNA SYNTHETASE (PRORS))	5vad	BIFUNCTIONAL GLUTAMATE/PROLINE--T RNA LIGASE (Homo sapiens)	10 / 12	LEU A1087 GLU A1100 VAL A1101 PRO A1120 ARG A1152 TRP A1169 GLU A1171 HIS A1173 THR A1240 GLY A1274	None None None None PRO  A1602 ( 3.4A) None PRO  A1602 ( 4.7A) PRO  A1602 ( 4.5A) 91Y  A1601 (-4.2A) PRO  A1602 (-3.7A)	0.76A	55.43
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	5XIQ_D_HFGD1002_0 (PROLYL-TRNA SYNTHETASE (PRORS))	5vad	BIFUNCTIONAL GLUTAMATE/PROLINE--T RNA LIGASE (Homo sapiens)	5 / 12	LEU A1087 GLU A1100 VAL A1101 PRO A1120 THR A1222	None	1.12A	55.43
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	5XIQ_D_HFGD1002_0 (PROLYL-TRNA SYNTHETASE (PRORS))	5vad	BIFUNCTIONAL GLUTAMATE/PROLINE--T RNA LIGASE (Homo sapiens)	10 / 12	LEU A1087 GLU A1100 VAL A1101 PRO A1120 TRP A1169 GLU A1171 HIS A1173 PHE A1216 THR A1240 GLY A1274	None None None None None PRO  A1602 ( 4.7A) PRO  A1602 ( 4.5A) PRO  A1602 (-4.3A) 91Y  A1601 (-4.2A) PRO  A1602 (-3.7A)	0.90A	55.43
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	5XIQ_D_HFGD1002_0 (PROLYL-TRNA SYNTHETASE (PRORS))	5vad	BIFUNCTIONAL GLUTAMATE/PROLINE--T RNA LIGASE (Homo sapiens)	5 / 12	VAL A1101 PRO A1120 GLU A1171 HIS A1173 PHE A1248	None None PRO  A1602 ( 4.7A) PRO  A1602 ( 4.5A) None	1.33A	55.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5XIQ_D_HFGD1002_1 (PROLYL-TRNA SYNTHETASE (PRORS))	1m54	CYSTATHIONINE BETA-SYNTHASE (Homo sapiens)	3 / 3	THR A  87 GLU A 239 HIS A 232	None	0.91A	21.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5XIQ_D_HFGD1002_1 (PROLYL-TRNA SYNTHETASE (PRORS))	2i7t	CLEAVAGE AND POLYADENYLATION SPECIFICITY FACTOR 73 KDA SUBUNIT (Homo sapiens)	3 / 3	THR A 206 GLU A 204 HIS A 158	None None ZN  A 482 ( 3.3A)	0.87A	21.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5XIQ_D_HFGD1002_1 (PROLYL-TRNA SYNTHETASE (PRORS))	2xrc	HUMAN COMPLEMENT FACTOR I (Homo sapiens)	3 / 3	THR A 268 GLU A 270 HIS A 247	None	0.86A	22.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5XIQ_D_HFGD1002_1 (PROLYL-TRNA SYNTHETASE (PRORS))	3fe4	CARBONIC ANHYDRASE 6 (Homo sapiens)	3 / 3	THR A 220 GLU A 125 HIS A 111	None MG  A 901 ( 4.4A) MG  A 901 (-3.4A)	0.84A	20.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5XIQ_D_HFGD1002_1 (PROLYL-TRNA SYNTHETASE (PRORS))	3zwf	ZINC PHOSPHODIESTERASE ELAC PROTEIN 1 (Homo sapiens)	3 / 3	THR A 277 GLU A 275 HIS A 182	None None ZN  A1364 ( 3.5A)	0.82A	22.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5XIQ_D_HFGD1002_1 (PROLYL-TRNA SYNTHETASE (PRORS))	4ye9	GLUTAMINE--TRNA LIGASE (Homo sapiens)	3 / 3	THR A 333 GLU A 449 HIS A 442	None	0.83A	21.74
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	5XIQ_D_HFGD1002_1 (PROLYL-TRNA SYNTHETASE (PRORS))	5vad	BIFUNCTIONAL GLUTAMATE/PROLINE--T RNA LIGASE (Homo sapiens)	3 / 3	THR A1121 GLU A1123 HIS A1242	PRO  A1602 (-3.5A) PRO  A1602 (-2.8A) PRO  A1602 (-4.1A)	0.52A	55.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	6MN8_A_HFGA603_0 (UNCHARACTERIZED PROTEIN)	1kt8	BRANCHED-CHAIN AMINO ACID AMINOTRANSFERASE, MITOCHONDRIAL (Homo sapiens)	5 / 12	GLU A 288 VAL A 257 PRO A 259 TRP A 194 GLY A 199	None	1.20A	20.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	6MN8_A_HFGA603_0 (UNCHARACTERIZED PROTEIN)	2abj	BRANCHED-CHAIN-AMINO -ACID AMINOTRANSFERASE, CYTOSOLIC (Homo sapiens)	5 / 12	LEU A 309 GLU A 306 PRO A 277 TRP A 212 GLY A 217	None	1.43A	22.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	6MN8_A_HFGA603_0 (UNCHARACTERIZED PROTEIN)	2f28	SIALIDASE 2 (Homo sapiens)	5 / 12	LEU A 293 GLU A 225 VAL A 224 PRO A 315 GLU A 319	None	1.43A	19.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	6MN8_A_HFGA603_0 (UNCHARACTERIZED PROTEIN)	2pbh	PROCATHEPSIN B (Homo sapiens)	5 / 12	GLU A  53 VAL A  54 THR A 223 TRP A 225 GLY A 229	None	1.05A	17.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	6MN8_A_HFGA603_0 (UNCHARACTERIZED PROTEIN)	2pvs	PANCREATIC LIPASE-RELATED PROTEIN 2 (Homo sapiens)	5 / 12	GLU A 160 VAL A 123 PRO A  27 THR A  18 GLY A  17	None	1.33A	20.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	6MN8_A_HFGA603_0 (UNCHARACTERIZED PROTEIN)	3bpt	3-HYDROXYISOBUTYRYL- COA HYDROLASE (Homo sapiens)	5 / 12	LEU A 314 PRO A 176 HIS A 153 THR A 143 GLY A 147	None	1.16A	21.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	6MN8_A_HFGA603_0 (UNCHARACTERIZED PROTEIN)	3gym	PROSTASIN (Homo sapiens)	5 / 12	LEU A 171 VAL A 184 PRO A 225 THR A 210 GLY A 211	None	1.22A	18.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	6MN8_A_HFGA603_0 (UNCHARACTERIZED PROTEIN)	4giw	RUN AND SH3 DOMAIN-CONTAINING PROTEIN 1 (Homo sapiens)	5 / 12	LEU A  67 GLU A  88 VAL A  86 THR A  76 GLY A  77	None	1.02A	15.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	6MN8_A_HFGA603_0 (UNCHARACTERIZED PROTEIN)	4gs4	ALPHA-TUBULIN N-ACETYLTRANSFERASE (Homo sapiens)	5 / 12	LEU A 164 VAL A 184 PRO A 159 THR A  65 SER A  54	None	1.29A	19.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	6MN8_A_HFGA603_0 (UNCHARACTERIZED PROTEIN)	4if5	ALPHA-TUBULIN N-ACETYLTRANSFERASE (Homo sapiens)	5 / 12	LEU A 164 VAL A 184 PRO A 159 THR A  65 SER A  54	None None None CL  A 202 (-4.0A) None	1.26A	15.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	6MN8_A_HFGA603_0 (UNCHARACTERIZED PROTEIN)	4m6w	FANCONI ANEMIA GROUP M PROTEIN FANCONI ANEMIA-ASSOCIATED PROTEIN OF 24 KDA (Homo sapiens; Homo sapiens)	5 / 12	LEU A1933 VAL B 109 HIS A1841 THR A1818 GLY A1815	None	1.31A	19.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	6MN8_A_HFGA603_0 (UNCHARACTERIZED PROTEIN)	4ruh	CYTOSOLIC NON-SPECIFIC DIPEPTIDASE (Homo sapiens)	5 / 12	LEU A 451 VAL A 437 PRO A 136 SER A  30 GLY A 164	None	1.32A	21.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	6MN8_A_HFGA603_0 (UNCHARACTERIZED PROTEIN)	5jk7	URACIL-DNA GLYCOSYLASE PROTEIN VPR (Homo sapiens; Human immunodeficiency virus 1)	5 / 12	LEU F  23 PRO D 271 HIS F  40 THR D 266 GLY D 246	None	1.39A	11.51
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	6MN8_A_HFGA603_0 (UNCHARACTERIZED PROTEIN)	5vad	BIFUNCTIONAL GLUTAMATE/PROLINE--T RNA LIGASE (Homo sapiens)	5 / 12	GLU A1154 THR A1240 SER A1272 TRP A1273 GLY A1274	91Y  A1601 (-4.6A) 91Y  A1601 (-4.2A) PRO  A1602 (-3.3A) None PRO  A1602 (-3.7A)	0.69A	59.07
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	6MN8_A_HFGA603_0 (UNCHARACTERIZED PROTEIN)	5vad	BIFUNCTIONAL GLUTAMATE/PROLINE--T RNA LIGASE (Homo sapiens)	11 / 12	LEU A1087 GLU A1100 VAL A1101 PRO A1120 TRP A1169 GLU A1171 HIS A1173 THR A1240 SER A1272 TRP A1273 GLY A1274	None None None None None PRO  A1602 ( 4.7A) PRO  A1602 ( 4.5A) 91Y  A1601 (-4.2A) PRO  A1602 (-3.3A) None PRO  A1602 (-3.7A)	0.69A	59.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	6MN8_A_HFGA603_1 (UNCHARACTERIZED PROTEIN)	1t46	HOMO SAPIENS V-KIT HARDY-ZUCKERMAN 4 FELINE SARCOMA VIRAL ONCOGENE HOMOLOG (Homo sapiens)	4 / 4	THR A 661 GLU A 583 ARG A 634 HIS A 580	None	1.28A	20.42
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	6MN8_A_HFGA603_1 (UNCHARACTERIZED PROTEIN)	5vad	BIFUNCTIONAL GLUTAMATE/PROLINE--T RNA LIGASE (Homo sapiens)	4 / 4	THR A1121 GLU A1123 ARG A1152 HIS A1242	PRO  A1602 (-3.5A) PRO  A1602 (-2.8A) PRO  A1602 ( 3.4A) PRO  A1602 (-4.1A)	0.45A	59.07