POTENTIAL TARGETS FROM HUMAN (RESULTS FROM SUB-STRUCTURAL SIMILARITY SEARCHES)
1) User may click on the DrReposER ID (the second column) to get information on the binding sites and drug molecule.
2) Click View (the second last column) to view matched residues and superposition in the NGL viewer (upper right part).
3) User may also click on the Dock (the last column) to get script for molecular docking in UCSF Chimera through AutoDock Vina.

DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IJX_B_HCZB800_1
(GLUTAMATE RECEPTOR 2)		1wh3 59 KDA
2'-5'-OLIGOADENYLATE
SYNTHETASE LIKE
PROTEIN
(Homo
sapiens)		5 / 10LEU A  63
SER A  28
ILE A   8
SER A   6
GLY A   7
None
1.37A16.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IJX_B_HCZB800_1
(GLUTAMATE RECEPTOR 2)		3ihj ALANINE
AMINOTRANSFERASE 2
(Homo
sapiens)		5 / 10LYS A  85
PRO A  86
LEU A  79
ILE A  75
GLY A 475
None
1.23A18.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IJX_B_HCZB800_1
(GLUTAMATE RECEPTOR 2)		3mos TRANSKETOLASE
(Homo
sapiens)		5 / 10LEU A 262
ILE A 248
SER A  43
SER A  40
GLY A 245
None
None
TPP  A 700 ( 4.3A)
TPP  A 700 (-2.5A)
None
1.19A20.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IJX_B_HCZB800_1
(GLUTAMATE RECEPTOR 2)		4r7a HISTONE-BINDING
PROTEIN RBBP4
(Homo
sapiens)		5 / 10SER B 280
LEU B 306
ILE B 254
SER B 234
GLY B 244
None
1.22A19.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IJX_B_HCZB800_1
(GLUTAMATE RECEPTOR 2)		5hzw MALTOSE-BINDING
PERIPLASMIC
PROTEIN,ENDOGLIN
(Escherichia
coli;
Homo
sapiens)		5 / 10LEU A 572
SER A 485
ILE A 514
PRO A 515
GLY A 513
None
1.37A17.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IJX_B_HCZB800_1
(GLUTAMATE RECEPTOR 2)		5kc8 GLUTAMATE RECEPTOR
IONOTROPIC, DELTA-2
(Homo
sapiens)		5 / 10SER A 354
LEU A  93
ILE A  90
SER A 352
GLY A  89
None
1.35A19.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IJX_B_HCZB800_1
(GLUTAMATE RECEPTOR 2)		5lcw CELL DIVISION CYCLE
PROTEIN 20 HOMOLOG
(Homo
sapiens)		5 / 10SER Q 285
LEU Q 189
ILE Q 229
SER Q 273
GLY Q 244
None
1.39A19.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IJX_B_HCZB800_1
(GLUTAMATE RECEPTOR 2)		5lcw CELL DIVISION CYCLE
PROTEIN 20 HOMOLOG
(Homo
sapiens)		5 / 10SER R 285
LEU R 189
ILE R 229
SER R 273
GLY R 244
None
1.39A18.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IJX_B_HCZB800_1
(GLUTAMATE RECEPTOR 2)		5xtd NADH-UBIQUINONE
OXIDOREDUCTASE CHAIN
1
(Homo
sapiens)		5 / 10SER s 163
LEU s 237
ILE s 105
PRO s  88
GLY s 101
None
1.17A20.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IJX_D_HCZD800_1
(GLUTAMATE RECEPTOR 2)		5nfu SERINE/THREONINE-PRO
TEIN KINASE PLK1
(Homo
sapiens)		5 / 9ILE A 476
PRO A 469
SER A 466
SER A 450
LEU A 442
None
1.22A14.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IJX_H_HCZH800_1
(GLUTAMATE RECEPTOR 2)		1fgg GLUCURONYLTRANSFERAS
E I
(Homo
sapiens)		4 / 5PRO A 250
SER A 246
LEU A 285
SER A 286
None
1.49A19.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IJX_H_HCZH800_1
(GLUTAMATE RECEPTOR 2)		1jm7 BREAST CANCER TYPE 1
SUSCEPTIBILITY
PROTEIN
(Homo
sapiens)		4 / 5LYS A  45
SER A  80
LEU A  73
SER A  36
None
1.43A19.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IJX_H_HCZH800_1
(GLUTAMATE RECEPTOR 2)		1k4q GLUTATHIONE
REDUCTASE
(Homo
sapiens)		4 / 5PRO A 169
SER A 166
LEU A 173
SER A 172
None
1.38A20.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IJX_H_HCZH800_1
(GLUTAMATE RECEPTOR 2)		1nug PROTEIN-GLUTAMINE
GLUTAMYLTRANSFERASE
E
(Homo
sapiens)		4 / 5LYS A 505
SER A 541
LEU A 507
SER A 481
None
1.19A16.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IJX_H_HCZH800_1
(GLUTAMATE RECEPTOR 2)		1soj CGMP-INHIBITED
3',5'-CYCLIC
PHOSPHODIESTERASE B
(Homo
sapiens)		4 / 5PRO A 756
SER A 793
LEU A 802
SER A 803
None
1.29A20.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IJX_H_HCZH800_1
(GLUTAMATE RECEPTOR 2)		2doc NEURAL CELL ADHESION
MOLECULE 2
(Homo
sapiens)		4 / 5PRO A 112
SER A 114
LEU A  29
SER A  30
None
1.41A25.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IJX_H_HCZH800_1
(GLUTAMATE RECEPTOR 2)		2mpm EOTAXIN
(Homo
sapiens)		4 / 5LYS A  73
PRO A  72
SER A  69
SER A  25
None
1.49A13.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IJX_H_HCZH800_1
(GLUTAMATE RECEPTOR 2)		3bfn KINESIN-LIKE PROTEIN
KIF22
(Homo
sapiens)		4 / 5LYS A 213
PRO A 214
SER A 216
LEU A 188
None
1.38A19.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IJX_H_HCZH800_1
(GLUTAMATE RECEPTOR 2)		3v4p INTEGRIN ALPHA-4
(Homo
sapiens)		4 / 5PRO A 358
SER A 400
LEU A 363
SER A 395
None
1.21A18.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IJX_H_HCZH800_1
(GLUTAMATE RECEPTOR 2)		3w8h SERINE/THREONINE-PRO
TEIN KINASE 25
(Homo
sapiens)		4 / 5LYS B  -2
PRO B 398
SER B 396
SER B 401
None
1.13A16.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IJX_H_HCZH800_1
(GLUTAMATE RECEPTOR 2)		4eyc CATHELICIDIN
ANTIMICROBIAL
PEPTIDE
(Homo
sapiens)		4 / 5LYS A  75
PRO A  76
SER A  78
LEU A 114
None
1.06A18.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IJX_H_HCZH800_1
(GLUTAMATE RECEPTOR 2)		4v2d FIBRONECTIN LEUCINE
RICH TRANSMEMBRANE
PROTEIN 2
(Homo
sapiens)		4 / 5PRO A 179
SER A 160
LEU A 206
SER A 205
None
1.45A21.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IJX_H_HCZH800_1
(GLUTAMATE RECEPTOR 2)		5anb ELONGATION FACTOR TU
GTP-BINDING
DOMAIN-CONTAINING
PROTEIN 1
(Homo
sapiens)		4 / 5LYS K 493
PRO K 494
SER K 489
LEU K 496
None
1.20A13.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IJX_H_HCZH800_1
(GLUTAMATE RECEPTOR 2)		5ggg PROTEIN
O-LINKED-MANNOSE
BETA-1,2-N-ACETYLGLU
COSAMINYLTRANSFERASE
1
(Homo
sapiens)		4 / 5PRO A 493
SER A 423
LEU A 530
SER A 409
None
1.20A19.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IJX_H_HCZH800_1
(GLUTAMATE RECEPTOR 2)		5gve DNA TOPOISOMERASE
3-BETA-1
(Homo
sapiens)		4 / 5LYS A  10
PRO A  11
SER A  37
SER A  16
None
0.88A19.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IJX_H_HCZH800_1
(GLUTAMATE RECEPTOR 2)		5jn9 CARBONIC ANHYDRASE 4
(Homo
sapiens)		4 / 5LYS A 169
PRO A 168
SER A 165
SER A 240
None
1.40A22.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IJX_H_HCZH800_1
(GLUTAMATE RECEPTOR 2)		5jsb INDUCED MYELOID
LEUKEMIA CELL
DIFFERENTIATION
PROTEIN MCL-1
(Homo
sapiens)		4 / 5PRO A 289
SER A 285
LEU A 179
SER A 183
None
1.16A21.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IJX_H_HCZH800_1
(GLUTAMATE RECEPTOR 2)		5mev INDUCED MYELOID
LEUKEMIA CELL
DIFFERENTIATION
PROTEIN MCL-1
HOMOLOG,INDUCED
MYELOID LEUKEMIA
CELL DIFFERENTIATION
PROTEIN MCL-1
(Homo
sapiens;
Mus
musculus)		4 / 5PRO A 289
SER A 285
LEU A 179
SER A 183
None
1.17A22.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IK6_B_HCZB262_1
(GLUTAMATE RECEPTOR 2)		2jbh PHOSPHORIBOSYLTRANSF
ERASE
DOMAIN-CONTAINING
PROTEIN 1
(Homo
sapiens)		5 / 10ILE A  64
SER A 101
GLY A  65
SER A  93
LEU A 138
None
1.42A22.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IK6_B_HCZB262_1
(GLUTAMATE RECEPTOR 2)		3kba PROGESTERONE
RECEPTOR
(Homo
sapiens)		5 / 10ILE A 804
PRO A 805
SER A 767
GLY A 764
LEU A 883
None
1.40A22.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IK6_B_HCZB262_1
(GLUTAMATE RECEPTOR 2)		3mos TRANSKETOLASE
(Homo
sapiens)		5 / 10ILE A 248
SER A  43
SER A  40
GLY A 245
LEU A 262
None
TPP  A 700 ( 4.3A)
TPP  A 700 (-2.5A)
None
None
1.43A20.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IK6_B_HCZB262_1
(GLUTAMATE RECEPTOR 2)		5kc8 GLUTAMATE RECEPTOR
IONOTROPIC, DELTA-2
(Homo
sapiens)		5 / 10ILE A  90
SER A 352
GLY A  89
SER A 354
LEU A  93
None
1.24A19.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IK6_B_HCZB262_1
(GLUTAMATE RECEPTOR 2)		5xtd NADH-UBIQUINONE
OXIDOREDUCTASE CHAIN
1
(Homo
sapiens)		5 / 10ILE s 105
PRO s  88
GLY s 101
SER s 163
LEU s 237
None
1.19A20.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IK6_B_HCZB800_1
(GLUTAMATE RECEPTOR 2)		3mos TRANSKETOLASE
(Homo
sapiens)		5 / 10LEU A 262
ILE A 248
SER A  43
SER A  40
GLY A 245
None
None
TPP  A 700 ( 4.3A)
TPP  A 700 (-2.5A)
None
1.19A20.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IK6_B_HCZB800_1
(GLUTAMATE RECEPTOR 2)		3ux9 INTERFERON
ALPHA-1/13
SCFV ANTIBODY
(Homo
sapiens)		5 / 10LEU B 213
ILE B 185
SER A  27
SER B 165
GLY B 187
None
1.46A21.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IK6_B_HCZB800_1
(GLUTAMATE RECEPTOR 2)		5u0r DH270.UCA1 LIGHT
CHAIN
(Homo
sapiens)		5 / 10SER L  31
LEU L 100
SER L  92
ILE L  98
GLY L  95
None
1.41A21.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IK6_H_HCZH800_1
(GLUTAMATE RECEPTOR 2)		1jm7 BREAST CANCER TYPE 1
SUSCEPTIBILITY
PROTEIN
(Homo
sapiens)		4 / 4LYS A  45
SER A  80
LEU A  73
SER A  36
None
1.41A19.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IK6_H_HCZH800_1
(GLUTAMATE RECEPTOR 2)		1nug PROTEIN-GLUTAMINE
GLUTAMYLTRANSFERASE
E
(Homo
sapiens)		4 / 4LYS A 505
SER A 541
LEU A 507
SER A 481
None
1.23A16.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IK6_H_HCZH800_1
(GLUTAMATE RECEPTOR 2)		5x68 KYNURENINE
3-MONOOXYGENASE
(Homo
sapiens)		4 / 4LYS A  53
SER A 232
LEU A  56
SER A 108
None
None
FAD  A 401 (-4.1A)
None
1.45A16.18