POTENTIAL TARGETS FROM HUMAN (RESULTS FROM SUB-STRUCTURAL SIMILARITY SEARCHES)
1) User may click on the DrReposER ID (the second column) to get information on the binding sites and drug molecule.
2) Click View (the second last column) to view matched residues and superposition in the NGL viewer (upper right part).
3) User may also click on the Dock (the last column) to get script for molecular docking in UCSF Chimera through AutoDock Vina.

DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1AM6_A_HAEA555_1
(CARBONIC ANHYDRASE)		1hvy THYMIDYLATE SYNTHASE
(Homo
sapiens)		4 / 7HIS A  28
LEU A  74
THR A  75
THR A  76
None
0.65A22.67
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1AM6_A_HAEA555_1
(CARBONIC ANHYDRASE)		1jd0 CARBONIC ANHYDRASE
XII
(Homo
sapiens)		7 / 7HIS A  94
HIS A  96
HIS A 119
LEU A 198
THR A 199
THR A 200
TRP A 209
 ZN  A 901 ( 3.2A)
ZN  A 901 ( 3.2A)
ZN  A 901 ( 3.1A)
AZM  A1400 (-3.9A)
AZM  A1400 (-3.6A)
AZM  A1400 (-3.3A)
None
0.22A36.33
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1AM6_A_HAEA555_1
(CARBONIC ANHYDRASE)		1jd0 CARBONIC ANHYDRASE
XII
(Homo
sapiens)		4 / 7HIS A 119
HIS A  94
HIS A  96
THR A 200
 ZN  A 901 ( 3.1A)
ZN  A 901 ( 3.2A)
ZN  A 901 ( 3.2A)
AZM  A1400 (-3.3A)
1.05A36.33
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1AM6_A_HAEA555_1
(CARBONIC ANHYDRASE)		2it4 CARBONIC ANHYDRASE 1
(Homo
sapiens)		6 / 7HIS A  94
HIS A  96
HIS A 119
LEU A 198
THR A 199
TRP A 209
 ZN  A 561 ( 3.2A)
ZN  A 561 ( 3.2A)
ZN  A 561 ( 3.1A)
PPF  A 500 (-3.9A)
PPF  A 500 (-3.6A)
None
0.21A60.55
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1AM6_A_HAEA555_1
(CARBONIC ANHYDRASE)		2w2j CARBONIC
ANHYDRASE-RELATED
PROTEIN
(Homo
sapiens)		5 / 7HIS A 118
HIS A 141
LEU A 222
THR A 223
TRP A 233
 CL  A 401 (-4.2A)
CL  A 401 (-4.1A)
None
CL  A 401 ( 4.8A)
None
0.27A38.72
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1AM6_A_HAEA555_1
(CARBONIC ANHYDRASE)		3da2 CARBONIC ANHYDRASE
13
(Homo
sapiens)		6 / 7HIS A  95
HIS A  97
HIS A 120
LEU A 199
THR A 200
TRP A 210
 ZN  A 301 ( 3.6A)
ZN  A 301 ( 3.5A)
ZN  A 301 ( 3.2A)
4MD  A 401 (-4.2A)
4MD  A 401 (-3.2A)
None
0.40A59.54
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1AM6_A_HAEA555_1
(CARBONIC ANHYDRASE)		3fe4 CARBONIC ANHYDRASE 6
(Homo
sapiens)		6 / 7HIS A 111
HIS A 113
HIS A 138
LEU A 219
THR A 220
TRP A 230
 MG  A 901 (-3.4A)
MG  A 901 (-3.4A)
MG  A 901 (-3.2A)
None
None
None
0.70A34.25
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1AM6_A_HAEA555_1
(CARBONIC ANHYDRASE)		3fe4 CARBONIC ANHYDRASE 6
(Homo
sapiens)		4 / 7HIS A 113
HIS A 138
HIS A 111
THR A 220
 MG  A 901 (-3.4A)
MG  A 901 (-3.2A)
MG  A 901 (-3.4A)
None
0.97A34.25
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1AM6_A_HAEA555_1
(CARBONIC ANHYDRASE)		3fe4 CARBONIC ANHYDRASE 6
(Homo
sapiens)		4 / 7LEU A 219
THR A 220
THR A 221
TRP A 230
None
0.44A34.25
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1AM6_A_HAEA555_1
(CARBONIC ANHYDRASE)		3jxf RECEPTOR-TYPE
TYROSINE-PROTEIN
PHOSPHATASE ZETA
(Homo
sapiens)		4 / 7HIS A 129
LEU A 235
THR A 236
TRP A 246
None
0.28A30.29
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1AM6_A_HAEA555_1
(CARBONIC ANHYDRASE)		3ml5 CARBONIC ANHYDRASE 7
(Homo
sapiens)		7 / 7HIS A  94
HIS A  96
HIS A 119
LEU A 198
THR A 199
THR A 200
TRP A 209
 ZN  A 263 ( 3.2A)
ZN  A 263 ( 3.2A)
ZN  A 263 ( 3.1A)
AZM  A 264 (-3.4A)
AZM  A 264 (-3.4A)
AZM  A 264 (-3.5A)
None
0.17A55.81
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1AM6_A_HAEA555_1
(CARBONIC ANHYDRASE)		3ml5 CARBONIC ANHYDRASE 7
(Homo
sapiens)		4 / 7HIS A 119
HIS A  94
HIS A  96
THR A 200
 ZN  A 263 ( 3.1A)
ZN  A 263 ( 3.2A)
ZN  A 263 ( 3.2A)
AZM  A 264 (-3.5A)
1.02A55.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1AM6_A_HAEA555_1
(CARBONIC ANHYDRASE)		3pkj NAD-DEPENDENT
DEACETYLASE
SIRTUIN-6
(Homo
sapiens)		4 / 7HIS A 117
HIS A  93
LEU A 211
THR A  49
None
1.02A22.92
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1AM6_A_HAEA555_1
(CARBONIC ANHYDRASE)		3uyq CARBONIC ANHYDRASE 3
(Homo
sapiens)		6 / 7HIS A  94
HIS A  96
HIS A 119
THR A 198
THR A 199
TRP A 208
 ZN  A 261 (-3.3A)
ZN  A 261 (-3.3A)
ZN  A 261 (-3.2A)
ZN  A 261 ( 4.4A)
None
None
0.33A58.46
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1AM6_A_HAEA555_1
(CARBONIC ANHYDRASE)		3uyq CARBONIC ANHYDRASE 3
(Homo
sapiens)		4 / 7HIS A 119
HIS A  94
HIS A  96
THR A 199
 ZN  A 261 (-3.2A)
ZN  A 261 (-3.3A)
ZN  A 261 (-3.3A)
None
1.02A58.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1AM6_A_HAEA555_1
(CARBONIC ANHYDRASE)		4cns DIHYDROPYRIMIDINASE-
LIKE 3
(Homo
sapiens)		4 / 7HIS A  75
HIS A  73
HIS A 107
THR A 253
None
1.08A19.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1AM6_A_HAEA555_1
(CARBONIC ANHYDRASE)		4cnt DIHYDROPYRIMIDINASE-
LIKE 3
(Homo
sapiens)		4 / 7HIS A  75
HIS A  73
HIS A 107
THR A 253
None
1.10A18.32
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1AM6_A_HAEA555_1
(CARBONIC ANHYDRASE)		4qk3 CARBONIC ANHYDRASE 2
(Homo
sapiens)		4 / 7HIS A  64
THR A 200
THR A 199
TRP A   5
None
None
ZN  A 301 ( 4.4A)
None
1.08A95.75
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1AM6_A_HAEA555_1
(CARBONIC ANHYDRASE)		4qk3 CARBONIC ANHYDRASE 2
(Homo
sapiens)		7 / 7HIS A  94
HIS A  96
HIS A 119
LEU A 198
THR A 199
THR A 200
TRP A 209
 ZN  A 301 (-3.2A)
ZN  A 301 (-3.2A)
ZN  A 301 (-3.1A)
None
ZN  A 301 ( 4.4A)
None
None
0.22A95.75
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1AM6_A_HAEA555_1
(CARBONIC ANHYDRASE)		4qk3 CARBONIC ANHYDRASE 2
(Homo
sapiens)		6 / 7HIS A  94
HIS A 119
LEU A 198
THR A 199
THR A 200
TRP A 209
 ZN  A 301 (-3.2A)
ZN  A 301 (-3.1A)
None
ZN  A 301 ( 4.4A)
None
None
1.46A95.75
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1AM6_A_HAEA555_1
(CARBONIC ANHYDRASE)		4qk3 CARBONIC ANHYDRASE 2
(Homo
sapiens)		4 / 7HIS A 119
HIS A  94
HIS A  96
THR A 200
 ZN  A 301 (-3.1A)
ZN  A 301 (-3.2A)
ZN  A 301 (-3.2A)
None
1.02A95.75
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1AM6_A_HAEA555_1
(CARBONIC ANHYDRASE)		5cjf CARBONIC ANHYDRASE
14
(Homo
sapiens)		7 / 7HIS A  94
HIS A  96
HIS A 119
LEU A 198
THR A 199
THR A 200
TRP A 209
 ZN  A 301 (-3.2A)
ZN  A 301 ( 3.2A)
ZN  A 301 ( 3.1A)
520  A 302 (-3.6A)
520  A 302 (-3.4A)
GOL  A 303 ( 3.5A)
None
0.25A36.80
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1AM6_A_HAEA555_1
(CARBONIC ANHYDRASE)		5jn9 CARBONIC ANHYDRASE 4
(Homo
sapiens)		7 / 7HIS A  94
HIS A  96
HIS A 119
LEU A 198
THR A 199
THR A 200
TRP A 209
 ZN  A 301 ( 3.3A)
ZN  A 301 ( 3.3A)
ZN  A 301 ( 3.2A)
EZL  A 302 (-3.5A)
EZL  A 302 (-3.4A)
EZL  A 302 (-3.9A)
None
0.25A35.42
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1AM6_A_HAEA555_1
(CARBONIC ANHYDRASE)		5jn9 CARBONIC ANHYDRASE 4
(Homo
sapiens)		4 / 7HIS A 119
HIS A  94
HIS A  96
THR A 200
 ZN  A 301 ( 3.2A)
ZN  A 301 ( 3.3A)
ZN  A 301 ( 3.3A)
EZL  A 302 (-3.9A)
1.05A35.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1AM6_A_HAEA555_1
(CARBONIC ANHYDRASE)		5zqz TRIFUNCTIONAL ENZYME
SUBUNIT ALPHA,
MITOCHONDRIAL
(Homo
sapiens)		4 / 7HIS A 498
LEU A 551
THR A 548
THR A 547
None
0.82A16.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1AM6_A_HAEA555_1
(CARBONIC ANHYDRASE)		6fe1 CARBONIC ANHYDRASE 9
(Homo
sapiens)		7 / 7HIS A  94
HIS A  96
HIS A 119
LEU A 198
THR A 199
THR A 200
TRP A 209
 ZN  A 301 ( 3.2A)
ZN  A 301 ( 3.2A)
ZN  A 301 ( 3.1A)
V14  A 302 (-3.6A)
V14  A 302 (-3.2A)
V14  A 302 (-3.5A)
None
0.36A14.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1E9Y_B_HAEB800_1
(UREASE SUBUNIT BETA)		2i7t CLEAVAGE AND
POLYADENYLATION
SPECIFICITY FACTOR
73 KDA SUBUNIT
(Homo
sapiens)		5 / 5HIS A  76
HIS A 158
HIS A 396
HIS A 418
ASP A  75
 ZN  A 481 (-3.4A)
ZN  A 482 ( 3.3A)
SO4  A 491 (-4.0A)
ZN  A 481 ( 3.4A)
ZN  A 481 ( 2.6A)
1.20A22.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1E9Y_B_HAEB800_1
(UREASE SUBUNIT BETA)		2vr2 DIHYDROPYRIMIDINASE
(Homo
sapiens)		4 / 5HIS A  67
HIS A 192
HIS A 248
ASP A 326
 ZN  A1494 (-3.3A)
ZN  A1495 (-3.7A)
ZN  A1495 (-3.4A)
ZN  A1494 (-2.7A)
0.74A24.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1E9Y_B_HAEB800_1
(UREASE SUBUNIT BETA)		2y1h PUTATIVE
DEOXYRIBONUCLEASE
TATDN3
(Homo
sapiens)		4 / 5HIS A  12
HIS A  70
HIS A 147
ASP A 218
 ZN  A1274 ( 3.2A)
PO4  A1275 (-3.8A)
ZN  A1273 ( 3.1A)
PO4  A1275 ( 2.7A)
0.65A18.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1E9Y_B_HAEB800_1
(UREASE SUBUNIT BETA)		3zwf ZINC
PHOSPHODIESTERASE
ELAC PROTEIN 1
(Homo
sapiens)		4 / 5HIS A  67
HIS A 182
HIS A 313
ASP A  66
 ZN  A1363 (-3.4A)
ZN  A1364 ( 3.5A)
ZN  A1363 ( 3.4A)
ZN  A1363 ( 2.6A)
0.90A20.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1E9Y_B_HAEB800_1
(UREASE SUBUNIT BETA)		4c6o CAD PROTEIN
(Homo
sapiens)		4 / 5HIS A1471
HIS A1590
HIS A1614
ASP A1686
 ZN  A2822 ( 3.2A)
ZN  A2823 (-3.0A)
ZN  A2823 (-3.2A)
ZN  A2822 (-2.6A)
0.59A20.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1E9Y_B_HAEB800_1
(UREASE SUBUNIT BETA)		5ao0 DEOXYNUCLEOSIDE
TRIPHOSPHATE
TRIPHOSPHOHYDROLASE
SAMHD1
(Homo
sapiens)		4 / 5HIS A 206
HIS A 210
HIS A 233
ASP A 311
 FE  A1001 ( 3.2A)
DG3  A2001 (-4.6A)
DG3  A2001 (-3.4A)
FE  A1001 ( 2.6A)
0.96A21.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FWE_C_HAEC989_1
(UREASE)		1kcw CERULOPLASMIN
(Homo
sapiens)		5 / 6HIS A 161
HIS A 163
HIS A1020
HIS A 978
HIS A 103
 CU  A1051 (-3.3A)
CU  A1050 (-3.3A)
CU  A1050 (-3.2A)
CU  A1052 ( 3.2A)
CU  A1051 (-3.3A)
1.22A19.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FWE_C_HAEC989_1
(UREASE)		2i7t CLEAVAGE AND
POLYADENYLATION
SPECIFICITY FACTOR
73 KDA SUBUNIT
(Homo
sapiens)		5 / 6HIS A  76
HIS A 158
HIS A 396
HIS A 418
ASP A  75
 ZN  A 481 (-3.4A)
ZN  A 482 ( 3.3A)
SO4  A 491 (-4.0A)
ZN  A 481 ( 3.4A)
ZN  A 481 ( 2.6A)
1.18A22.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FWE_C_HAEC989_1
(UREASE)		2ibn INOSITOL OXYGENASE
(Homo
sapiens)		5 / 6HIS A 123
HIS A  98
HIS A 194
HIS A 220
ASP A 253
 FE  A 703 (-3.3A)
FE  A 703 (-3.2A)
FE  A 704 ( 3.5A)
FE  A 704 ( 3.4A)
FE  A 703 (-2.5A)
1.15A16.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FWE_C_HAEC989_1
(UREASE)		2vr2 DIHYDROPYRIMIDINASE
(Homo
sapiens)		5 / 6HIS A  67
HIS A  69
HIS A 192
HIS A 248
ASP A 326
 ZN  A1494 (-3.3A)
ZN  A1494 (-3.3A)
ZN  A1495 (-3.7A)
ZN  A1495 (-3.4A)
ZN  A1494 (-2.7A)
0.83A22.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FWE_C_HAEC989_1
(UREASE)		2y1h PUTATIVE
DEOXYRIBONUCLEASE
TATDN3
(Homo
sapiens)		5 / 6HIS A  12
HIS A  14
HIS A  70
HIS A 147
ASP A 218
 ZN  A1274 ( 3.2A)
ZN  A1274 ( 3.3A)
PO4  A1275 (-3.8A)
ZN  A1273 ( 3.1A)
PO4  A1275 ( 2.7A)
0.64A20.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FWE_C_HAEC989_1
(UREASE)		4c6o CAD PROTEIN
(Homo
sapiens)		5 / 6HIS A1471
HIS A1473
HIS A1590
HIS A1614
ASP A1686
 ZN  A2822 ( 3.2A)
ZN  A2822 ( 3.2A)
ZN  A2823 (-3.0A)
ZN  A2823 (-3.2A)
ZN  A2822 (-2.6A)
0.62A20.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1OS2_A_HAEA874_1
(MACROPHAGE
METALLOELASTASE)		1ck7 PROTEIN (GELATINASE
A)
(Homo
sapiens)		4 / 5HIS A 193
HIS A 403
HIS A 407
HIS A 413
 ZN  A 991 ( 3.1A)
ZN  A 990 ( 3.4A)
ZN  A 990 ( 3.3A)
ZN  A 990 ( 3.4A)
0.41A18.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1OS2_A_HAEA874_1
(MACROPHAGE
METALLOELASTASE)		1eak 72 KDA TYPE IV
COLLAGENASE
(Homo
sapiens)		4 / 5HIS A 193
HIS A 403
HIS A 407
HIS A 413
 ZN  A 996 (-3.1A)
ZN  A 997 (-3.5A)
ZN  A 997 (-3.6A)
ZN  A 997 (-3.5A)
0.39A26.98
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1OS2_A_HAEA874_1
(MACROPHAGE
METALLOELASTASE)		1hfs STROMELYSIN-1
(Homo
sapiens)		5 / 5HIS A 166
HIS A 201
GLU A 202
HIS A 205
HIS A 211
 ZN  A 258 ( 3.0A)
ZN  A 257 ( 3.1A)
L04  A 256 ( 2.7A)
ZN  A 257 ( 3.2A)
ZN  A 257 ( 3.1A)
0.43A58.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1OS2_A_HAEA874_1
(MACROPHAGE
METALLOELASTASE)		1l6j MATRIX
METALLOPROTEINASE-9
(Homo
sapiens)		5 / 5HIS A 190
HIS A 401
GLU A 402
HIS A 405
HIS A 411
 ZN  A 501 (-3.4A)
ZN  A 500 (-3.4A)
ZN  A 500 ( 4.3A)
ZN  A 500 (-3.2A)
ZN  A 500 (-3.4A)
0.21A20.84
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1OS2_A_HAEA874_1
(MACROPHAGE
METALLOELASTASE)		1qib 72 KDA TYPE IV
COLLAGENASE
(Homo
sapiens)		5 / 5HIS A 166
HIS A 201
GLU A 202
HIS A 205
HIS A 211
 ZN  A 502 (-3.5A)
ZN  A 501 (-3.5A)
ZN  A 501 ( 4.5A)
ZN  A 501 (-3.5A)
ZN  A 501 (-3.5A)
0.27A58.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1OS2_A_HAEA874_1
(MACROPHAGE
METALLOELASTASE)		1r55 ADAM 33
(Homo
sapiens)		4 / 5HIS A 345
GLU A 346
HIS A 349
HIS A 355
 ZN  A 201 ( 3.3A)
097  A 518 (-2.9A)
ZN  A 201 ( 3.2A)
ZN  A 201 ( 3.3A)
0.32A25.68
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1OS2_A_HAEA874_1
(MACROPHAGE
METALLOELASTASE)		1rm8 MATRIX
METALLOPROTEINASE-16
(Homo
sapiens)		5 / 5HIS A 208
HIS A 246
GLU A 247
HIS A 250
HIS A 256
 ZN  A 501 (-3.2A)
ZN  A 500 ( 3.3A)
BAT  A 800 (-2.7A)
ZN  A 500 ( 3.2A)
ZN  A 500 ( 3.3A)
0.22A51.18
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1OS2_A_HAEA874_1
(MACROPHAGE
METALLOELASTASE)		1slm STROMELYSIN-1
(Homo
sapiens)		5 / 5HIS A 166
HIS A 201
GLU A 202
HIS A 205
HIS A 211
 ZN  A 258 ( 3.0A)
ZN  A 257 ( 3.0A)
ZN  A 257 ( 4.1A)
ZN  A 257 ( 3.2A)
ZN  A 257 ( 3.1A)
0.22A40.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1OS2_A_HAEA874_1
(MACROPHAGE
METALLOELASTASE)		1su3 INTERSTITIAL
COLLAGENASE
(Homo
sapiens)		4 / 5HIS A 183
HIS A 218
HIS A 222
HIS A 228
 ZN  A 915 (-3.3A)
ZN  A 913 (-3.2A)
ZN  A 913 (-3.2A)
ZN  A 913 (-3.2A)
0.23A21.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1OS2_A_HAEA874_1
(MACROPHAGE
METALLOELASTASE)		1xcr HYPOTHETICAL PROTEIN
PTD012
(Homo
sapiens)		4 / 5HIS A 268
GLU A 110
HIS A 278
HIS A 266
 ZN  A1001 ( 3.2A)
ACY  A2001 ( 3.7A)
ZN  A1001 ( 3.2A)
ZN  A1001 ( 3.2A)
0.96A20.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1OS2_A_HAEA874_1
(MACROPHAGE
METALLOELASTASE)		2fv5 ADAM 17
(Homo
sapiens)		4 / 5HIS A 405
GLU A 406
HIS A 409
HIS A 415
 ZN  A   3 ( 3.2A)
541  A   1 (-2.6A)
ZN  A   3 ( 3.3A)
ZN  A   3 ( 3.2A)
0.28A21.40
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1OS2_A_HAEA874_1
(MACROPHAGE
METALLOELASTASE)		2jsd MATRIX
METALLOPROTEINASE-20
(Homo
sapiens)		5 / 5HIS A 191
HIS A 226
GLU A 227
HIS A 230
HIS A 236
 ZN  A 275 (-3.4A)
NGH  A 277 ( 3.0A)
NGH  A 277 (-3.6A)
ZN  A 276 ( 3.3A)
ZN  A 276 ( 3.0A)
0.83A53.70
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1OS2_A_HAEA874_1
(MACROPHAGE
METALLOELASTASE)		2oy4 NEUTROPHIL
COLLAGENASE
(Homo
sapiens)		5 / 5HIS A 162
HIS A 197
GLU A 198
HIS A 201
HIS A 207
 ZN  A 998 (-3.3A)
ZN  A 999 (-3.2A)
ZN  A 999 ( 4.4A)
ZN  A 999 (-3.4A)
ZN  A 999 (-3.2A)
0.16A53.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1OS2_A_HAEA874_1
(MACROPHAGE
METALLOELASTASE)		2rjq ADAMTS-5
(Homo
sapiens)		4 / 5HIS A 410
GLU A 411
HIS A 414
HIS A 420
 ZN  A   1 ( 3.2A)
BAT  A 559 (-2.5A)
ZN  A   1 ( 3.3A)
ZN  A   1 ( 3.3A)
0.17A16.76
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1OS2_A_HAEA874_1
(MACROPHAGE
METALLOELASTASE)		2y6c MATRILYSIN
(Homo
sapiens)		5 / 5HIS A 183
HIS A 219
GLU A 220
HIS A 223
HIS A 229
 ZN  A1266 ( 3.3A)
ZN  A1267 ( 3.2A)
TQI  A1269 (-2.9A)
ZN  A1267 ( 3.3A)
ZN  A1267 ( 3.2A)
0.28A53.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1OS2_A_HAEA874_1
(MACROPHAGE
METALLOELASTASE)		3b8z PROTEIN ADAMTS-5
(Homo
sapiens)		4 / 5HIS A 410
GLU A 411
HIS A 414
HIS A 420
 ZN  A 901 ( 3.2A)
294  A 801 (-2.7A)
ZN  A 901 ( 3.3A)
ZN  A 901 ( 3.3A)
0.16A23.64
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1OS2_A_HAEA874_1
(MACROPHAGE
METALLOELASTASE)		3ba0 MACROPHAGE
METALLOELASTASE
(Homo
sapiens)		5 / 5HIS A 183
HIS A 218
GLU A 219
HIS A 222
HIS A 228
 ZN  A 472 (-3.1A)
ZN  A 471 (-4.0A)
ZN  A 471 ( 3.2A)
HAE  A 477 ( 3.1A)
ZN  A 471 (-3.7A)
0.58A100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1OS2_A_HAEA874_1
(MACROPHAGE
METALLOELASTASE)		3edi TOLLOID-LIKE PROTEIN
1
(Homo
sapiens)		4 / 5HIS A  92
GLU A  93
HIS A  96
HIS A 102
 ZN  A 210 (-3.2A)
ZN  A 210 ( 4.3A)
ZN  A 210 (-3.3A)
ZN  A 210 (-3.2A)
0.17A23.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1OS2_A_HAEA874_1
(MACROPHAGE
METALLOELASTASE)		3hig AMILORIDE-SENSITIVE
AMINE OXIDASE
(Homo
sapiens)		4 / 5HIS A 486
HIS A 512
HIS A 510
HIS A 675
None
CU  A 801 (-3.2A)
CU  A 801 (-3.3A)
CU  A 801 (-3.0A)
1.08A11.63
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1OS2_A_HAEA874_1
(MACROPHAGE
METALLOELASTASE)		3o2x COLLAGENASE 3
(Homo
sapiens)		5 / 5HIS A1187
HIS A1222
GLU A1223
HIS A1226
HIS A1232
 ZN  A1998 ( 3.2A)
ZN  A1999 ( 3.2A)
3O2  A1801 (-2.7A)
ZN  A1999 ( 3.4A)
ZN  A1999 ( 3.2A)
0.32A56.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1OS2_A_HAEA874_1
(MACROPHAGE
METALLOELASTASE)		3q2h A DISINTEGRIN AND
METALLOPROTEINASE
WITH THROMBOSPONDIN
MOTIFS 1
(Homo
sapiens)		4 / 5HIS A 149
GLU A 150
HIS A 153
HIS A 159
 ZN  A 401 ( 3.3A)
QHF  A   1 (-2.6A)
QHF  A   1 ( 3.0A)
ZN  A 401 ( 3.2A)
0.19A19.67
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1OS2_A_HAEA874_1
(MACROPHAGE
METALLOELASTASE)		3shi INTERSTITIAL
COLLAGENASE
(Homo
sapiens)		5 / 5HIS A 183
HIS A 218
GLU A 219
HIS A 222
HIS A 228
 ZN  A 302 (-3.1A)
ZN  A 301 (-3.3A)
ZN  A 301 ( 4.7A)
ZN  A 301 (-3.4A)
ZN  A 301 (-3.3A)
0.27A57.32
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1OS2_A_HAEA874_1
(MACROPHAGE
METALLOELASTASE)		3v96 STROMELYSIN-2
(Homo
sapiens)		5 / 5HIS B 182
HIS B 217
GLU B 218
HIS B 221
HIS B 227
 ZN  B 302 (-3.2A)
ZN  B 301 (-3.2A)
ZN  B 301 ( 3.9A)
ZN  B 301 (-3.3A)
ZN  B 301 (-3.2A)
0.23A55.76
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1OS2_A_HAEA874_1
(MACROPHAGE
METALLOELASTASE)		4auo INTERSTITIAL
COLLAGENASE
(Homo
sapiens)		4 / 5HIS A 164
HIS A 199
HIS A 203
HIS A 209
 ZN  A1201 (-3.1A)
ZN  A1202 (-3.0A)
ZN  A1202 (-3.1A)
ZN  A1202 (-3.4A)
0.12A35.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1OS2_A_HAEA874_1
(MACROPHAGE
METALLOELASTASE)		4dd8 DISINTEGRIN AND
METALLOPROTEINASE
DOMAIN-CONTAINING
PROTEIN 8
(Homo
sapiens)		4 / 5HIS A 334
GLU A 335
HIS A 338
HIS A 344
 ZN  A1002 ( 3.3A)
BAT  A1000 (-2.7A)
ZN  A1002 (-3.3A)
ZN  A1002 ( 3.3A)
0.42A23.92
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1OS2_A_HAEA874_1
(MACROPHAGE
METALLOELASTASE)		4fvl COLLAGENASE 3
(Homo
sapiens)		4 / 5HIS A 187
HIS A 222
HIS A 226
HIS A 232
 ZN  A 502 (-3.3A)
ZN  A 501 (-3.3A)
ZN  A 501 (-3.1A)
ZN  A 501 (-3.2A)
0.31A32.32
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1OS2_A_HAEA874_1
(MACROPHAGE
METALLOELASTASE)		4gr8 MACROPHAGE
METALLOELASTASE
(Homo
sapiens)		5 / 5HIS A 183
HIS A 218
GLU A 219
HIS A 222
HIS A 228
 ZN  A 302 (-3.2A)
R4C  A 306 ( 3.2A)
R4C  A 306 (-2.7A)
ZN  A 301 ( 3.2A)
ZN  A 301 ( 3.2A)
0.28A100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1OS2_A_HAEA874_1
(MACROPHAGE
METALLOELASTASE)		4gwn MEPRIN A SUBUNIT
BETA
(Homo
sapiens)		4 / 5HIS A 152
GLU A 153
HIS A 156
HIS A 162
 CD  A 701 (-3.7A)
CD  A 701 (-3.5A)
CD  A 701 (-3.7A)
CD  A 701 (-3.7A)
0.25A13.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1OS2_A_HAEA874_1
(MACROPHAGE
METALLOELASTASE)		4qgn 1,2-DIHYDROXY-3-KETO
-5-METHYLTHIOPENTENE
DIOXYGENASE
(Homo
sapiens)		4 / 5HIS A 133
GLU A  94
HIS A  90
HIS A  88
 FE  A 201 (-3.3A)
FE  A 201 ( 2.7A)
FE  A 201 (-3.3A)
FE  A 201 (-3.4A)
1.02A19.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1OS2_A_HAEA874_1
(MACROPHAGE
METALLOELASTASE)		4wk7 A DISINTEGRIN AND
METALLOPROTEINASE
WITH THROMBOSPONDIN
MOTIFS 4
(Homo
sapiens)		4 / 5HIS A 361
GLU A 362
HIS A 365
HIS A 371
 ZN  A 501 ( 3.2A)
3PQ  A 505 (-2.6A)
ZN  A 501 ( 3.3A)
ZN  A 501 ( 3.2A)
0.29A22.07
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1OS2_A_HAEA874_1
(MACROPHAGE
METALLOELASTASE)		4xct MATRIX
METALLOPROTEINASE-9,
MATRIX
METALLOPROTEINASE-9
(Homo
sapiens)		5 / 5HIS A 190
HIS A 226
GLU A 227
HIS A 230
HIS A 236
 ZN  A 303 ( 3.2A)
ZN  A 302 ( 3.2A)
N73  A 301 (-2.5A)
ZN  A 302 ( 3.3A)
ZN  A 302 ( 3.3A)
0.17A49.69
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1OS2_A_HAEA874_1
(MACROPHAGE
METALLOELASTASE)		5h0u MATRIX
METALLOPROTEINASE-14
(Homo
sapiens)		5 / 5HIS A 201
HIS A 239
GLU A 240
HIS A 243
HIS A 249
 ZN  A 303 (-3.2A)
ZN  A 302 ( 3.3A)
GOL  A 311 (-4.2A)
ZN  A 302 (-3.4A)
ZN  A 302 (-3.2A)
0.26A50.59
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1OS2_A_HAEA874_1
(MACROPHAGE
METALLOELASTASE)		5th6 MATRIX
METALLOPROTEINASE-9,
MATRIX
METALLOPROTEINASE-9
(Homo
sapiens)		5 / 5HIS A 190
HIS A 401
GLU A 402
HIS A 405
HIS A 411
 ZN  A 502 (-3.2A)
ZN  A 501 (-3.3A)
ZN  A 501 ( 4.2A)
ZN  A 501 (-3.2A)
ZN  A 501 (-3.1A)
0.19A36.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1OS2_A_HAEA874_1
(MACROPHAGE
METALLOELASTASE)		6bdz DISINTEGRIN AND
METALLOPROTEINASE
DOMAIN-CONTAINING
PROTEIN 10
(Homo
sapiens)		4 / 5HIS A 383
GLU A 384
HIS A 387
HIS A 393
 ZN  A 705 (-3.3A)
ZN  A 705 (-3.8A)
ZN  A 705 (-4.0A)
ZN  A 705 (-3.2A)
0.39A19.39
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1OS2_D_HAED574_1
(MACROPHAGE
METALLOELASTASE)		1hfs STROMELYSIN-1
(Homo
sapiens)		4 / 4HIS A 201
GLU A 202
HIS A 205
HIS A 211
 ZN  A 257 ( 3.1A)
L04  A 256 ( 2.7A)
ZN  A 257 ( 3.2A)
ZN  A 257 ( 3.1A)
0.20A58.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1OS2_D_HAED574_1
(MACROPHAGE
METALLOELASTASE)		1l6j MATRIX
METALLOPROTEINASE-9
(Homo
sapiens)		4 / 4HIS A 401
GLU A 402
HIS A 405
HIS A 411
 ZN  A 500 (-3.4A)
ZN  A 500 ( 4.3A)
ZN  A 500 (-3.2A)
ZN  A 500 (-3.4A)
0.24A20.84
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1OS2_D_HAED574_1
(MACROPHAGE
METALLOELASTASE)		1qib 72 KDA TYPE IV
COLLAGENASE
(Homo
sapiens)		4 / 4HIS A 201
GLU A 202
HIS A 205
HIS A 211
 ZN  A 501 (-3.5A)
ZN  A 501 ( 4.5A)
ZN  A 501 (-3.5A)
ZN  A 501 (-3.5A)
0.30A58.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1OS2_D_HAED574_1
(MACROPHAGE
METALLOELASTASE)		1r55 ADAM 33
(Homo
sapiens)		4 / 4HIS A 345
GLU A 346
HIS A 349
HIS A 355
 ZN  A 201 ( 3.3A)
097  A 518 (-2.9A)
ZN  A 201 ( 3.2A)
ZN  A 201 ( 3.3A)
0.28A25.68
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1OS2_D_HAED574_1
(MACROPHAGE
METALLOELASTASE)		1rm8 MATRIX
METALLOPROTEINASE-16
(Homo
sapiens)		4 / 4HIS A 246
GLU A 247
HIS A 250
HIS A 256
 ZN  A 500 ( 3.3A)
BAT  A 800 (-2.7A)
ZN  A 500 ( 3.2A)
ZN  A 500 ( 3.3A)
0.17A51.18
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1OS2_D_HAED574_1
(MACROPHAGE
METALLOELASTASE)		1slm STROMELYSIN-1
(Homo
sapiens)		4 / 4HIS A 201
GLU A 202
HIS A 205
HIS A 211
 ZN  A 257 ( 3.0A)
ZN  A 257 ( 4.1A)
ZN  A 257 ( 3.2A)
ZN  A 257 ( 3.1A)
0.23A40.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1OS2_D_HAED574_1
(MACROPHAGE
METALLOELASTASE)		1xcr HYPOTHETICAL PROTEIN
PTD012
(Homo
sapiens)		4 / 4HIS A 268
GLU A 110
HIS A 278
HIS A 266
 ZN  A1001 ( 3.2A)
ACY  A2001 ( 3.7A)
ZN  A1001 ( 3.2A)
ZN  A1001 ( 3.2A)
0.94A20.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1OS2_D_HAED574_1
(MACROPHAGE
METALLOELASTASE)		2fv5 ADAM 17
(Homo
sapiens)		4 / 4HIS A 405
GLU A 406
HIS A 409
HIS A 415
 ZN  A   3 ( 3.2A)
541  A   1 (-2.6A)
ZN  A   3 ( 3.3A)
ZN  A   3 ( 3.2A)
0.25A21.40
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1OS2_D_HAED574_1
(MACROPHAGE
METALLOELASTASE)		2jsd MATRIX
METALLOPROTEINASE-20
(Homo
sapiens)		4 / 4HIS A 226
GLU A 227
HIS A 230
HIS A 236
NGH  A 277 ( 3.0A)
NGH  A 277 (-3.6A)
ZN  A 276 ( 3.3A)
ZN  A 276 ( 3.0A)
0.64A53.70
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1OS2_D_HAED574_1
(MACROPHAGE
METALLOELASTASE)		2oy4 NEUTROPHIL
COLLAGENASE
(Homo
sapiens)		4 / 4HIS A 197
GLU A 198
HIS A 201
HIS A 207
 ZN  A 999 (-3.2A)
ZN  A 999 ( 4.4A)
ZN  A 999 (-3.4A)
ZN  A 999 (-3.2A)
0.16A53.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1OS2_D_HAED574_1
(MACROPHAGE
METALLOELASTASE)		2rjq ADAMTS-5
(Homo
sapiens)		4 / 4HIS A 410
GLU A 411
HIS A 414
HIS A 420
 ZN  A   1 ( 3.2A)
BAT  A 559 (-2.5A)
ZN  A   1 ( 3.3A)
ZN  A   1 ( 3.3A)
0.16A16.76
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1OS2_D_HAED574_1
(MACROPHAGE
METALLOELASTASE)		2y6c MATRILYSIN
(Homo
sapiens)		4 / 4HIS A 219
GLU A 220
HIS A 223
HIS A 229
 ZN  A1267 ( 3.2A)
TQI  A1269 (-2.9A)
ZN  A1267 ( 3.3A)
ZN  A1267 ( 3.2A)
0.21A53.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1OS2_D_HAED574_1
(MACROPHAGE
METALLOELASTASE)		3b8z PROTEIN ADAMTS-5
(Homo
sapiens)		4 / 4HIS A 410
GLU A 411
HIS A 414
HIS A 420
 ZN  A 901 ( 3.2A)
294  A 801 (-2.7A)
ZN  A 901 ( 3.3A)
ZN  A 901 ( 3.3A)
0.13A23.64
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1OS2_D_HAED574_1
(MACROPHAGE
METALLOELASTASE)		3ba0 MACROPHAGE
METALLOELASTASE
(Homo
sapiens)		4 / 4HIS A 218
GLU A 219
HIS A 222
HIS A 228
 ZN  A 471 (-4.0A)
ZN  A 471 ( 3.2A)
HAE  A 477 ( 3.1A)
ZN  A 471 (-3.7A)
0.40A100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1OS2_D_HAED574_1
(MACROPHAGE
METALLOELASTASE)		3edi TOLLOID-LIKE PROTEIN
1
(Homo
sapiens)		4 / 4HIS A  92
GLU A  93
HIS A  96
HIS A 102
 ZN  A 210 (-3.2A)
ZN  A 210 ( 4.3A)
ZN  A 210 (-3.3A)
ZN  A 210 (-3.2A)
0.18A23.27
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1OS2_D_HAED574_1
(MACROPHAGE
METALLOELASTASE)		3o2x COLLAGENASE 3
(Homo
sapiens)		4 / 4HIS A1222
GLU A1223
HIS A1226
HIS A1232
 ZN  A1999 ( 3.2A)
3O2  A1801 (-2.7A)
ZN  A1999 ( 3.4A)
ZN  A1999 ( 3.2A)
0.21A56.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1OS2_D_HAED574_1
(MACROPHAGE
METALLOELASTASE)		3q2h A DISINTEGRIN AND
METALLOPROTEINASE
WITH THROMBOSPONDIN
MOTIFS 1
(Homo
sapiens)		4 / 4HIS A 149
GLU A 150
HIS A 153
HIS A 159
 ZN  A 401 ( 3.3A)
QHF  A   1 (-2.6A)
QHF  A   1 ( 3.0A)
ZN  A 401 ( 3.2A)
0.17A19.67
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1OS2_D_HAED574_1
(MACROPHAGE
METALLOELASTASE)		3shi INTERSTITIAL
COLLAGENASE
(Homo
sapiens)		4 / 4HIS A 218
GLU A 219
HIS A 222
HIS A 228
 ZN  A 301 (-3.3A)
ZN  A 301 ( 4.7A)
ZN  A 301 (-3.4A)
ZN  A 301 (-3.3A)
0.26A57.32
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1OS2_D_HAED574_1
(MACROPHAGE
METALLOELASTASE)		3v96 STROMELYSIN-2
(Homo
sapiens)		4 / 4HIS B 217
GLU B 218
HIS B 221
HIS B 227
 ZN  B 301 (-3.2A)
ZN  B 301 ( 3.9A)
ZN  B 301 (-3.3A)
ZN  B 301 (-3.2A)
0.26A55.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1OS2_D_HAED574_1
(MACROPHAGE
METALLOELASTASE)		4dd8 DISINTEGRIN AND
METALLOPROTEINASE
DOMAIN-CONTAINING
PROTEIN 8
(Homo
sapiens)		4 / 4HIS A 334
GLU A 335
HIS A 338
HIS A 344
 ZN  A1002 ( 3.3A)
BAT  A1000 (-2.7A)
ZN  A1002 (-3.3A)
ZN  A1002 ( 3.3A)
0.42A23.92
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1OS2_D_HAED574_1
(MACROPHAGE
METALLOELASTASE)		4gr8 MACROPHAGE
METALLOELASTASE
(Homo
sapiens)		4 / 4HIS A 218
GLU A 219
HIS A 222
HIS A 228
R4C  A 306 ( 3.2A)
R4C  A 306 (-2.7A)
ZN  A 301 ( 3.2A)
ZN  A 301 ( 3.2A)
0.23A100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1OS2_D_HAED574_1
(MACROPHAGE
METALLOELASTASE)		4gwn MEPRIN A SUBUNIT
BETA
(Homo
sapiens)		4 / 4HIS A 152
GLU A 153
HIS A 156
HIS A 162
 CD  A 701 (-3.7A)
CD  A 701 (-3.5A)
CD  A 701 (-3.7A)
CD  A 701 (-3.7A)
0.28A13.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1OS2_D_HAED574_1
(MACROPHAGE
METALLOELASTASE)		4qgn 1,2-DIHYDROXY-3-KETO
-5-METHYLTHIOPENTENE
DIOXYGENASE
(Homo
sapiens)		4 / 4HIS A 133
GLU A  94
HIS A  90
HIS A  88
 FE  A 201 (-3.3A)
FE  A 201 ( 2.7A)
FE  A 201 (-3.3A)
FE  A 201 (-3.4A)
1.02A19.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1OS2_D_HAED574_1
(MACROPHAGE
METALLOELASTASE)		4wk7 A DISINTEGRIN AND
METALLOPROTEINASE
WITH THROMBOSPONDIN
MOTIFS 4
(Homo
sapiens)		4 / 4HIS A 361
GLU A 362
HIS A 365
HIS A 371
 ZN  A 501 ( 3.2A)
3PQ  A 505 (-2.6A)
ZN  A 501 ( 3.3A)
ZN  A 501 ( 3.2A)
0.25A22.07
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1OS2_D_HAED574_1
(MACROPHAGE
METALLOELASTASE)		4xct MATRIX
METALLOPROTEINASE-9,
MATRIX
METALLOPROTEINASE-9
(Homo
sapiens)		4 / 4HIS A 226
GLU A 227
HIS A 230
HIS A 236
 ZN  A 302 ( 3.2A)
N73  A 301 (-2.5A)
ZN  A 302 ( 3.3A)
ZN  A 302 ( 3.3A)
0.13A49.69
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1OS2_D_HAED574_1
(MACROPHAGE
METALLOELASTASE)		5h0u MATRIX
METALLOPROTEINASE-14
(Homo
sapiens)		4 / 4HIS A 239
GLU A 240
HIS A 243
HIS A 249
 ZN  A 302 ( 3.3A)
GOL  A 311 (-4.2A)
ZN  A 302 (-3.4A)
ZN  A 302 (-3.2A)
0.17A50.59
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1OS2_D_HAED574_1
(MACROPHAGE
METALLOELASTASE)		5th6 MATRIX
METALLOPROTEINASE-9,
MATRIX
METALLOPROTEINASE-9
(Homo
sapiens)		4 / 4HIS A 401
GLU A 402
HIS A 405
HIS A 411
 ZN  A 501 (-3.3A)
ZN  A 501 ( 4.2A)
ZN  A 501 (-3.2A)
ZN  A 501 (-3.1A)
0.19A36.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1OS2_D_HAED574_1
(MACROPHAGE
METALLOELASTASE)		6bdz DISINTEGRIN AND
METALLOPROTEINASE
DOMAIN-CONTAINING
PROTEIN 10
(Homo
sapiens)		4 / 4HIS A 383
GLU A 384
HIS A 387
HIS A 393
 ZN  A 705 (-3.3A)
ZN  A 705 (-3.8A)
ZN  A 705 (-4.0A)
ZN  A 705 (-3.2A)
0.44A19.39
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1UTT_A_HAEA1265_1
(MACROPHAGE
METALLOELASTASE)		1hfs STROMELYSIN-1
(Homo
sapiens)		4 / 4HIS A 201
GLU A 202
HIS A 205
HIS A 211
 ZN  A 257 ( 3.1A)
L04  A 256 ( 2.7A)
ZN  A 257 ( 3.2A)
ZN  A 257 ( 3.1A)
0.21A60.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UTT_A_HAEA1265_1
(MACROPHAGE
METALLOELASTASE)		1kcw CERULOPLASMIN
(Homo
sapiens)		4 / 4HIS A 101
GLU A 112
HIS A 980
HIS A 978
 CU  A1052 (-3.2A)
None
CU  A1050 (-3.0A)
CU  A1052 ( 3.2A)
1.31A9.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UTT_A_HAEA1265_1
(MACROPHAGE
METALLOELASTASE)		1l6j MATRIX
METALLOPROTEINASE-9
(Homo
sapiens)		4 / 4HIS A 401
GLU A 402
HIS A 405
HIS A 411
 ZN  A 500 (-3.4A)
ZN  A 500 ( 4.3A)
ZN  A 500 (-3.2A)
ZN  A 500 (-3.4A)
0.20A23.22
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1UTT_A_HAEA1265_1
(MACROPHAGE
METALLOELASTASE)		1qib 72 KDA TYPE IV
COLLAGENASE
(Homo
sapiens)		4 / 4HIS A 201
GLU A 202
HIS A 205
HIS A 211
 ZN  A 501 (-3.5A)
ZN  A 501 ( 4.5A)
ZN  A 501 (-3.5A)
ZN  A 501 (-3.5A)
0.26A59.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UTT_A_HAEA1265_1
(MACROPHAGE
METALLOELASTASE)		1r55 ADAM 33
(Homo
sapiens)		4 / 4HIS A 345
GLU A 346
HIS A 349
HIS A 355
 ZN  A 201 ( 3.3A)
097  A 518 (-2.9A)
ZN  A 201 ( 3.2A)
ZN  A 201 ( 3.3A)
0.31A25.79
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1UTT_A_HAEA1265_1
(MACROPHAGE
METALLOELASTASE)		1rm8 MATRIX
METALLOPROTEINASE-16
(Homo
sapiens)		4 / 4HIS A 246
GLU A 247
HIS A 250
HIS A 256
 ZN  A 500 ( 3.3A)
BAT  A 800 (-2.7A)
ZN  A 500 ( 3.2A)
ZN  A 500 ( 3.3A)
0.22A50.89
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1UTT_A_HAEA1265_1
(MACROPHAGE
METALLOELASTASE)		1slm STROMELYSIN-1
(Homo
sapiens)		4 / 4HIS A 201
GLU A 202
HIS A 205
HIS A 211
 ZN  A 257 ( 3.0A)
ZN  A 257 ( 4.1A)
ZN  A 257 ( 3.2A)
ZN  A 257 ( 3.1A)
0.32A46.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UTT_A_HAEA1265_1
(MACROPHAGE
METALLOELASTASE)		1xcr HYPOTHETICAL PROTEIN
PTD012
(Homo
sapiens)		4 / 4HIS A 268
GLU A 110
HIS A 278
HIS A 266
 ZN  A1001 ( 3.2A)
ACY  A2001 ( 3.7A)
ZN  A1001 ( 3.2A)
ZN  A1001 ( 3.2A)
0.99A18.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UTT_A_HAEA1265_1
(MACROPHAGE
METALLOELASTASE)		2fv5 ADAM 17
(Homo
sapiens)		4 / 4HIS A 405
GLU A 406
HIS A 409
HIS A 415
 ZN  A   3 ( 3.2A)
541  A   1 (-2.6A)
ZN  A   3 ( 3.3A)
ZN  A   3 ( 3.2A)
0.28A21.76
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1UTT_A_HAEA1265_1
(MACROPHAGE
METALLOELASTASE)		2jsd MATRIX
METALLOPROTEINASE-20
(Homo
sapiens)		4 / 4HIS A 226
GLU A 227
HIS A 230
HIS A 236
NGH  A 277 ( 3.0A)
NGH  A 277 (-3.6A)
ZN  A 276 ( 3.3A)
ZN  A 276 ( 3.0A)
0.62A54.38
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1UTT_A_HAEA1265_1
(MACROPHAGE
METALLOELASTASE)		2oy4 NEUTROPHIL
COLLAGENASE
(Homo
sapiens)		4 / 4HIS A 197
GLU A 198
HIS A 201
HIS A 207
 ZN  A 999 (-3.2A)
ZN  A 999 ( 4.4A)
ZN  A 999 (-3.4A)
ZN  A 999 (-3.2A)
0.15A53.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UTT_A_HAEA1265_1
(MACROPHAGE
METALLOELASTASE)		2rjq ADAMTS-5
(Homo
sapiens)		4 / 4HIS A 410
GLU A 411
HIS A 414
HIS A 420
 ZN  A   1 ( 3.2A)
BAT  A 559 (-2.5A)
ZN  A   1 ( 3.3A)
ZN  A   1 ( 3.3A)
0.19A17.79
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1UTT_A_HAEA1265_1
(MACROPHAGE
METALLOELASTASE)		2y6c MATRILYSIN
(Homo
sapiens)		4 / 4HIS A 219
GLU A 220
HIS A 223
HIS A 229
 ZN  A1267 ( 3.2A)
TQI  A1269 (-2.9A)
ZN  A1267 ( 3.3A)
ZN  A1267 ( 3.2A)
0.13A54.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UTT_A_HAEA1265_1
(MACROPHAGE
METALLOELASTASE)		3b8z PROTEIN ADAMTS-5
(Homo
sapiens)		4 / 4HIS A 410
GLU A 411
HIS A 414
HIS A 420
 ZN  A 901 ( 3.2A)
294  A 801 (-2.7A)
ZN  A 901 ( 3.3A)
ZN  A 901 ( 3.3A)
0.22A23.15
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1UTT_A_HAEA1265_1
(MACROPHAGE
METALLOELASTASE)		3ba0 MACROPHAGE
METALLOELASTASE
(Homo
sapiens)		4 / 4HIS A 218
GLU A 219
HIS A 222
HIS A 228
 ZN  A 471 (-4.0A)
ZN  A 471 ( 3.2A)
HAE  A 477 ( 3.1A)
ZN  A 471 (-3.7A)
0.45A99.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UTT_A_HAEA1265_1
(MACROPHAGE
METALLOELASTASE)		3edi TOLLOID-LIKE PROTEIN
1
(Homo
sapiens)		4 / 4HIS A  92
GLU A  93
HIS A  96
HIS A 102
 ZN  A 210 (-3.2A)
ZN  A 210 ( 4.3A)
ZN  A 210 (-3.3A)
ZN  A 210 (-3.2A)
0.20A24.02
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1UTT_A_HAEA1265_1
(MACROPHAGE
METALLOELASTASE)		3o2x COLLAGENASE 3
(Homo
sapiens)		4 / 4HIS A1222
GLU A1223
HIS A1226
HIS A1232
 ZN  A1999 ( 3.2A)
3O2  A1801 (-2.7A)
ZN  A1999 ( 3.4A)
ZN  A1999 ( 3.2A)
0.26A56.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UTT_A_HAEA1265_1
(MACROPHAGE
METALLOELASTASE)		3q2h A DISINTEGRIN AND
METALLOPROTEINASE
WITH THROMBOSPONDIN
MOTIFS 1
(Homo
sapiens)		4 / 4HIS A 149
GLU A 150
HIS A 153
HIS A 159
 ZN  A 401 ( 3.3A)
QHF  A   1 (-2.6A)
QHF  A   1 ( 3.0A)
ZN  A 401 ( 3.2A)
0.21A18.48
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1UTT_A_HAEA1265_1
(MACROPHAGE
METALLOELASTASE)		3shi INTERSTITIAL
COLLAGENASE
(Homo
sapiens)		4 / 4HIS A 218
GLU A 219
HIS A 222
HIS A 228
 ZN  A 301 (-3.3A)
ZN  A 301 ( 4.7A)
ZN  A 301 (-3.4A)
ZN  A 301 (-3.3A)
0.24A58.02
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1UTT_A_HAEA1265_1
(MACROPHAGE
METALLOELASTASE)		3v96 STROMELYSIN-2
(Homo
sapiens)		4 / 4HIS B 217
GLU B 218
HIS B 221
HIS B 227
 ZN  B 301 (-3.2A)
ZN  B 301 ( 3.9A)
ZN  B 301 (-3.3A)
ZN  B 301 (-3.2A)
0.33A58.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UTT_A_HAEA1265_1
(MACROPHAGE
METALLOELASTASE)		4dd8 DISINTEGRIN AND
METALLOPROTEINASE
DOMAIN-CONTAINING
PROTEIN 8
(Homo
sapiens)		4 / 4HIS A 334
GLU A 335
HIS A 338
HIS A 344
 ZN  A1002 ( 3.3A)
BAT  A1000 (-2.7A)
ZN  A1002 (-3.3A)
ZN  A1002 ( 3.3A)
0.39A20.63
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1UTT_A_HAEA1265_1
(MACROPHAGE
METALLOELASTASE)		4gr8 MACROPHAGE
METALLOELASTASE
(Homo
sapiens)		4 / 4HIS A 218
GLU A 219
HIS A 222
HIS A 228
R4C  A 306 ( 3.2A)
R4C  A 306 (-2.7A)
ZN  A 301 ( 3.2A)
ZN  A 301 ( 3.2A)
0.18A99.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UTT_A_HAEA1265_1
(MACROPHAGE
METALLOELASTASE)		4gwn MEPRIN A SUBUNIT
BETA
(Homo
sapiens)		4 / 4HIS A 152
GLU A 153
HIS A 156
HIS A 162
 CD  A 701 (-3.7A)
CD  A 701 (-3.5A)
CD  A 701 (-3.7A)
CD  A 701 (-3.7A)
0.34A14.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UTT_A_HAEA1265_1
(MACROPHAGE
METALLOELASTASE)		4wk7 A DISINTEGRIN AND
METALLOPROTEINASE
WITH THROMBOSPONDIN
MOTIFS 4
(Homo
sapiens)		4 / 4HIS A 361
GLU A 362
HIS A 365
HIS A 371
 ZN  A 501 ( 3.2A)
3PQ  A 505 (-2.6A)
ZN  A 501 ( 3.3A)
ZN  A 501 ( 3.2A)
0.19A20.69
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1UTT_A_HAEA1265_1
(MACROPHAGE
METALLOELASTASE)		4xct MATRIX
METALLOPROTEINASE-9,
MATRIX
METALLOPROTEINASE-9
(Homo
sapiens)		4 / 4HIS A 226
GLU A 227
HIS A 230
HIS A 236
 ZN  A 302 ( 3.2A)
N73  A 301 (-2.5A)
ZN  A 302 ( 3.3A)
ZN  A 302 ( 3.3A)
0.13A50.31
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1UTT_A_HAEA1265_1
(MACROPHAGE
METALLOELASTASE)		5h0u MATRIX
METALLOPROTEINASE-14
(Homo
sapiens)		4 / 4HIS A 239
GLU A 240
HIS A 243
HIS A 249
 ZN  A 302 ( 3.3A)
GOL  A 311 (-4.2A)
ZN  A 302 (-3.4A)
ZN  A 302 (-3.2A)
0.10A50.59
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1UTT_A_HAEA1265_1
(MACROPHAGE
METALLOELASTASE)		5th6 MATRIX
METALLOPROTEINASE-9,
MATRIX
METALLOPROTEINASE-9
(Homo
sapiens)		4 / 4HIS A 401
GLU A 402
HIS A 405
HIS A 411
 ZN  A 501 (-3.3A)
ZN  A 501 ( 4.2A)
ZN  A 501 (-3.2A)
ZN  A 501 (-3.1A)
0.24A40.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UTT_A_HAEA1265_1
(MACROPHAGE
METALLOELASTASE)		6bdz DISINTEGRIN AND
METALLOPROTEINASE
DOMAIN-CONTAINING
PROTEIN 10
(Homo
sapiens)		4 / 4HIS A 383
GLU A 384
HIS A 387
HIS A 393
 ZN  A 705 (-3.3A)
ZN  A 705 (-3.8A)
ZN  A 705 (-4.0A)
ZN  A 705 (-3.2A)
0.51A20.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1UTZ_A_HAEA1267_1
(MACROPHAGE
METALLOELASTASE)		1hfs STROMELYSIN-1
(Homo
sapiens)		4 / 4HIS A 201
GLU A 202
HIS A 205
HIS A 211
 ZN  A 257 ( 3.1A)
L04  A 256 ( 2.7A)
ZN  A 257 ( 3.2A)
ZN  A 257 ( 3.1A)
0.23A60.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UTZ_A_HAEA1267_1
(MACROPHAGE
METALLOELASTASE)		1l6j MATRIX
METALLOPROTEINASE-9
(Homo
sapiens)		4 / 4HIS A 401
GLU A 402
HIS A 405
HIS A 411
 ZN  A 500 (-3.4A)
ZN  A 500 ( 4.3A)
ZN  A 500 (-3.2A)
ZN  A 500 (-3.4A)
0.20A23.22
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1UTZ_A_HAEA1267_1
(MACROPHAGE
METALLOELASTASE)		1qib 72 KDA TYPE IV
COLLAGENASE
(Homo
sapiens)		4 / 4HIS A 201
GLU A 202
HIS A 205
HIS A 211
 ZN  A 501 (-3.5A)
ZN  A 501 ( 4.5A)
ZN  A 501 (-3.5A)
ZN  A 501 (-3.5A)
0.28A59.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UTZ_A_HAEA1267_1
(MACROPHAGE
METALLOELASTASE)		1r55 ADAM 33
(Homo
sapiens)		4 / 4HIS A 345
GLU A 346
HIS A 349
HIS A 355
 ZN  A 201 ( 3.3A)
097  A 518 (-2.9A)
ZN  A 201 ( 3.2A)
ZN  A 201 ( 3.3A)
0.34A25.79
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1UTZ_A_HAEA1267_1
(MACROPHAGE
METALLOELASTASE)		1rm8 MATRIX
METALLOPROTEINASE-16
(Homo
sapiens)		4 / 4HIS A 246
GLU A 247
HIS A 250
HIS A 256
 ZN  A 500 ( 3.3A)
BAT  A 800 (-2.7A)
ZN  A 500 ( 3.2A)
ZN  A 500 ( 3.3A)
0.17A50.89
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1UTZ_A_HAEA1267_1
(MACROPHAGE
METALLOELASTASE)		1slm STROMELYSIN-1
(Homo
sapiens)		4 / 4HIS A 201
GLU A 202
HIS A 205
HIS A 211
 ZN  A 257 ( 3.0A)
ZN  A 257 ( 4.1A)
ZN  A 257 ( 3.2A)
ZN  A 257 ( 3.1A)
0.24A46.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UTZ_A_HAEA1267_1
(MACROPHAGE
METALLOELASTASE)		1xcr HYPOTHETICAL PROTEIN
PTD012
(Homo
sapiens)		4 / 4HIS A 268
GLU A 110
HIS A 278
HIS A 266
 ZN  A1001 ( 3.2A)
ACY  A2001 ( 3.7A)
ZN  A1001 ( 3.2A)
ZN  A1001 ( 3.2A)
0.97A18.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UTZ_A_HAEA1267_1
(MACROPHAGE
METALLOELASTASE)		2fv5 ADAM 17
(Homo
sapiens)		4 / 4HIS A 405
GLU A 406
HIS A 409
HIS A 415
 ZN  A   3 ( 3.2A)
541  A   1 (-2.6A)
ZN  A   3 ( 3.3A)
ZN  A   3 ( 3.2A)
0.29A21.76
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1UTZ_A_HAEA1267_1
(MACROPHAGE
METALLOELASTASE)		2jsd MATRIX
METALLOPROTEINASE-20
(Homo
sapiens)		4 / 4HIS A 226
GLU A 227
HIS A 230
HIS A 236
NGH  A 277 ( 3.0A)
NGH  A 277 (-3.6A)
ZN  A 276 ( 3.3A)
ZN  A 276 ( 3.0A)
0.60A54.38
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1UTZ_A_HAEA1267_1
(MACROPHAGE
METALLOELASTASE)		2oy4 NEUTROPHIL
COLLAGENASE
(Homo
sapiens)		4 / 4HIS A 197
GLU A 198
HIS A 201
HIS A 207
 ZN  A 999 (-3.2A)
ZN  A 999 ( 4.4A)
ZN  A 999 (-3.4A)
ZN  A 999 (-3.2A)
0.12A53.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UTZ_A_HAEA1267_1
(MACROPHAGE
METALLOELASTASE)		2rjq ADAMTS-5
(Homo
sapiens)		4 / 4HIS A 410
GLU A 411
HIS A 414
HIS A 420
 ZN  A   1 ( 3.2A)
BAT  A 559 (-2.5A)
ZN  A   1 ( 3.3A)
ZN  A   1 ( 3.3A)
0.19A17.79
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1UTZ_A_HAEA1267_1
(MACROPHAGE
METALLOELASTASE)		2y6c MATRILYSIN
(Homo
sapiens)		4 / 4HIS A 219
GLU A 220
HIS A 223
HIS A 229
 ZN  A1267 ( 3.2A)
TQI  A1269 (-2.9A)
ZN  A1267 ( 3.3A)
ZN  A1267 ( 3.2A)
0.20A54.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UTZ_A_HAEA1267_1
(MACROPHAGE
METALLOELASTASE)		3b8z PROTEIN ADAMTS-5
(Homo
sapiens)		4 / 4HIS A 410
GLU A 411
HIS A 414
HIS A 420
 ZN  A 901 ( 3.2A)
294  A 801 (-2.7A)
ZN  A 901 ( 3.3A)
ZN  A 901 ( 3.3A)
0.20A23.15
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1UTZ_A_HAEA1267_1
(MACROPHAGE
METALLOELASTASE)		3ba0 MACROPHAGE
METALLOELASTASE
(Homo
sapiens)		4 / 4HIS A 218
GLU A 219
HIS A 222
HIS A 228
 ZN  A 471 (-4.0A)
ZN  A 471 ( 3.2A)
HAE  A 477 ( 3.1A)
ZN  A 471 (-3.7A)
0.40A99.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UTZ_A_HAEA1267_1
(MACROPHAGE
METALLOELASTASE)		3edi TOLLOID-LIKE PROTEIN
1
(Homo
sapiens)		4 / 4HIS A  92
GLU A  93
HIS A  96
HIS A 102
 ZN  A 210 (-3.2A)
ZN  A 210 ( 4.3A)
ZN  A 210 (-3.3A)
ZN  A 210 (-3.2A)
0.15A24.02
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1UTZ_A_HAEA1267_1
(MACROPHAGE
METALLOELASTASE)		3o2x COLLAGENASE 3
(Homo
sapiens)		4 / 4HIS A1222
GLU A1223
HIS A1226
HIS A1232
 ZN  A1999 ( 3.2A)
3O2  A1801 (-2.7A)
ZN  A1999 ( 3.4A)
ZN  A1999 ( 3.2A)
0.18A56.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UTZ_A_HAEA1267_1
(MACROPHAGE
METALLOELASTASE)		3q2h A DISINTEGRIN AND
METALLOPROTEINASE
WITH THROMBOSPONDIN
MOTIFS 1
(Homo
sapiens)		4 / 4HIS A 149
GLU A 150
HIS A 153
HIS A 159
 ZN  A 401 ( 3.3A)
QHF  A   1 (-2.6A)
QHF  A   1 ( 3.0A)
ZN  A 401 ( 3.2A)
0.17A18.48
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1UTZ_A_HAEA1267_1
(MACROPHAGE
METALLOELASTASE)		3shi INTERSTITIAL
COLLAGENASE
(Homo
sapiens)		4 / 4HIS A 218
GLU A 219
HIS A 222
HIS A 228
 ZN  A 301 (-3.3A)
ZN  A 301 ( 4.7A)
ZN  A 301 (-3.4A)
ZN  A 301 (-3.3A)
0.28A58.02
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1UTZ_A_HAEA1267_1
(MACROPHAGE
METALLOELASTASE)		3v96 STROMELYSIN-2
(Homo
sapiens)		4 / 4HIS B 217
GLU B 218
HIS B 221
HIS B 227
 ZN  B 301 (-3.2A)
ZN  B 301 ( 3.9A)
ZN  B 301 (-3.3A)
ZN  B 301 (-3.2A)
0.26A58.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UTZ_A_HAEA1267_1
(MACROPHAGE
METALLOELASTASE)		4dd8 DISINTEGRIN AND
METALLOPROTEINASE
DOMAIN-CONTAINING
PROTEIN 8
(Homo
sapiens)		4 / 4HIS A 334
GLU A 335
HIS A 338
HIS A 344
 ZN  A1002 ( 3.3A)
BAT  A1000 (-2.7A)
ZN  A1002 (-3.3A)
ZN  A1002 ( 3.3A)
0.40A20.63
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1UTZ_A_HAEA1267_1
(MACROPHAGE
METALLOELASTASE)		4gr8 MACROPHAGE
METALLOELASTASE
(Homo
sapiens)		4 / 4HIS A 218
GLU A 219
HIS A 222
HIS A 228
R4C  A 306 ( 3.2A)
R4C  A 306 (-2.7A)
ZN  A 301 ( 3.2A)
ZN  A 301 ( 3.2A)
0.24A99.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UTZ_A_HAEA1267_1
(MACROPHAGE
METALLOELASTASE)		4gwn MEPRIN A SUBUNIT
BETA
(Homo
sapiens)		4 / 4HIS A 152
GLU A 153
HIS A 156
HIS A 162
 CD  A 701 (-3.7A)
CD  A 701 (-3.5A)
CD  A 701 (-3.7A)
CD  A 701 (-3.7A)
0.27A14.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UTZ_A_HAEA1267_1
(MACROPHAGE
METALLOELASTASE)		4qgn 1,2-DIHYDROXY-3-KETO
-5-METHYLTHIOPENTENE
DIOXYGENASE
(Homo
sapiens)		4 / 4HIS A 133
GLU A  94
HIS A  90
HIS A  88
 FE  A 201 (-3.3A)
FE  A 201 ( 2.7A)
FE  A 201 (-3.3A)
FE  A 201 (-3.4A)
1.05A20.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UTZ_A_HAEA1267_1
(MACROPHAGE
METALLOELASTASE)		4wk7 A DISINTEGRIN AND
METALLOPROTEINASE
WITH THROMBOSPONDIN
MOTIFS 4
(Homo
sapiens)		4 / 4HIS A 361
GLU A 362
HIS A 365
HIS A 371
 ZN  A 501 ( 3.2A)
3PQ  A 505 (-2.6A)
ZN  A 501 ( 3.3A)
ZN  A 501 ( 3.2A)
0.27A20.69
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1UTZ_A_HAEA1267_1
(MACROPHAGE
METALLOELASTASE)		4xct MATRIX
METALLOPROTEINASE-9,
MATRIX
METALLOPROTEINASE-9
(Homo
sapiens)		4 / 4HIS A 226
GLU A 227
HIS A 230
HIS A 236
 ZN  A 302 ( 3.2A)
N73  A 301 (-2.5A)
ZN  A 302 ( 3.3A)
ZN  A 302 ( 3.3A)
0.11A50.31
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1UTZ_A_HAEA1267_1
(MACROPHAGE
METALLOELASTASE)		5h0u MATRIX
METALLOPROTEINASE-14
(Homo
sapiens)		4 / 4HIS A 239
GLU A 240
HIS A 243
HIS A 249
 ZN  A 302 ( 3.3A)
GOL  A 311 (-4.2A)
ZN  A 302 (-3.4A)
ZN  A 302 (-3.2A)
0.15A50.59
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1UTZ_A_HAEA1267_1
(MACROPHAGE
METALLOELASTASE)		5th6 MATRIX
METALLOPROTEINASE-9,
MATRIX
METALLOPROTEINASE-9
(Homo
sapiens)		4 / 4HIS A 401
GLU A 402
HIS A 405
HIS A 411
 ZN  A 501 (-3.3A)
ZN  A 501 ( 4.2A)
ZN  A 501 (-3.2A)
ZN  A 501 (-3.1A)
0.18A40.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UTZ_A_HAEA1267_1
(MACROPHAGE
METALLOELASTASE)		6bdz DISINTEGRIN AND
METALLOPROTEINASE
DOMAIN-CONTAINING
PROTEIN 10
(Homo
sapiens)		4 / 4HIS A 383
GLU A 384
HIS A 387
HIS A 393
 ZN  A 705 (-3.3A)
ZN  A 705 (-3.8A)
ZN  A 705 (-4.0A)
ZN  A 705 (-3.2A)
0.41A20.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1UTZ_B_HAEB1266_1
(MACROPHAGE
METALLOELASTASE)		1hfs STROMELYSIN-1
(Homo
sapiens)		4 / 4HIS A 201
GLU A 202
HIS A 205
HIS A 211
 ZN  A 257 ( 3.1A)
L04  A 256 ( 2.7A)
ZN  A 257 ( 3.2A)
ZN  A 257 ( 3.1A)
0.21A60.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UTZ_B_HAEB1266_1
(MACROPHAGE
METALLOELASTASE)		1l6j MATRIX
METALLOPROTEINASE-9
(Homo
sapiens)		4 / 4HIS A 401
GLU A 402
HIS A 405
HIS A 411
 ZN  A 500 (-3.4A)
ZN  A 500 ( 4.3A)
ZN  A 500 (-3.2A)
ZN  A 500 (-3.4A)
0.25A23.22
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1UTZ_B_HAEB1266_1
(MACROPHAGE
METALLOELASTASE)		1qib 72 KDA TYPE IV
COLLAGENASE
(Homo
sapiens)		4 / 4HIS A 201
GLU A 202
HIS A 205
HIS A 211
 ZN  A 501 (-3.5A)
ZN  A 501 ( 4.5A)
ZN  A 501 (-3.5A)
ZN  A 501 (-3.5A)
0.30A59.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UTZ_B_HAEB1266_1
(MACROPHAGE
METALLOELASTASE)		1r55 ADAM 33
(Homo
sapiens)		4 / 4HIS A 345
GLU A 346
HIS A 349
HIS A 355
 ZN  A 201 ( 3.3A)
097  A 518 (-2.9A)
ZN  A 201 ( 3.2A)
ZN  A 201 ( 3.3A)
0.34A25.79
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1UTZ_B_HAEB1266_1
(MACROPHAGE
METALLOELASTASE)		1rm8 MATRIX
METALLOPROTEINASE-16
(Homo
sapiens)		4 / 4HIS A 246
GLU A 247
HIS A 250
HIS A 256
 ZN  A 500 ( 3.3A)
BAT  A 800 (-2.7A)
ZN  A 500 ( 3.2A)
ZN  A 500 ( 3.3A)
0.19A50.89
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1UTZ_B_HAEB1266_1
(MACROPHAGE
METALLOELASTASE)		1slm STROMELYSIN-1
(Homo
sapiens)		4 / 4HIS A 201
GLU A 202
HIS A 205
HIS A 211
 ZN  A 257 ( 3.0A)
ZN  A 257 ( 4.1A)
ZN  A 257 ( 3.2A)
ZN  A 257 ( 3.1A)
0.27A46.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UTZ_B_HAEB1266_1
(MACROPHAGE
METALLOELASTASE)		1xcr HYPOTHETICAL PROTEIN
PTD012
(Homo
sapiens)		4 / 4HIS A 268
GLU A 110
HIS A 278
HIS A 266
 ZN  A1001 ( 3.2A)
ACY  A2001 ( 3.7A)
ZN  A1001 ( 3.2A)
ZN  A1001 ( 3.2A)
0.94A18.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UTZ_B_HAEB1266_1
(MACROPHAGE
METALLOELASTASE)		2fv5 ADAM 17
(Homo
sapiens)		4 / 4HIS A 405
GLU A 406
HIS A 409
HIS A 415
 ZN  A   3 ( 3.2A)
541  A   1 (-2.6A)
ZN  A   3 ( 3.3A)
ZN  A   3 ( 3.2A)
0.28A21.76
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1UTZ_B_HAEB1266_1
(MACROPHAGE
METALLOELASTASE)		2jsd MATRIX
METALLOPROTEINASE-20
(Homo
sapiens)		4 / 4HIS A 226
GLU A 227
HIS A 230
HIS A 236
NGH  A 277 ( 3.0A)
NGH  A 277 (-3.6A)
ZN  A 276 ( 3.3A)
ZN  A 276 ( 3.0A)
0.60A54.38
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1UTZ_B_HAEB1266_1
(MACROPHAGE
METALLOELASTASE)		2oy4 NEUTROPHIL
COLLAGENASE
(Homo
sapiens)		4 / 4HIS A 197
GLU A 198
HIS A 201
HIS A 207
 ZN  A 999 (-3.2A)
ZN  A 999 ( 4.4A)
ZN  A 999 (-3.4A)
ZN  A 999 (-3.2A)
0.15A53.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UTZ_B_HAEB1266_1
(MACROPHAGE
METALLOELASTASE)		2rjq ADAMTS-5
(Homo
sapiens)		4 / 4HIS A 410
GLU A 411
HIS A 414
HIS A 420
 ZN  A   1 ( 3.2A)
BAT  A 559 (-2.5A)
ZN  A   1 ( 3.3A)
ZN  A   1 ( 3.3A)
0.20A17.79
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1UTZ_B_HAEB1266_1
(MACROPHAGE
METALLOELASTASE)		2y6c MATRILYSIN
(Homo
sapiens)		4 / 4HIS A 219
GLU A 220
HIS A 223
HIS A 229
 ZN  A1267 ( 3.2A)
TQI  A1269 (-2.9A)
ZN  A1267 ( 3.3A)
ZN  A1267 ( 3.2A)
0.18A54.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UTZ_B_HAEB1266_1
(MACROPHAGE
METALLOELASTASE)		3b8z PROTEIN ADAMTS-5
(Homo
sapiens)		4 / 4HIS A 410
GLU A 411
HIS A 414
HIS A 420
 ZN  A 901 ( 3.2A)
294  A 801 (-2.7A)
ZN  A 901 ( 3.3A)
ZN  A 901 ( 3.3A)
0.19A23.15
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1UTZ_B_HAEB1266_1
(MACROPHAGE
METALLOELASTASE)		3ba0 MACROPHAGE
METALLOELASTASE
(Homo
sapiens)		4 / 4HIS A 218
GLU A 219
HIS A 222
HIS A 228
 ZN  A 471 (-4.0A)
ZN  A 471 ( 3.2A)
HAE  A 477 ( 3.1A)
ZN  A 471 (-3.7A)
0.44A99.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UTZ_B_HAEB1266_1
(MACROPHAGE
METALLOELASTASE)		3edi TOLLOID-LIKE PROTEIN
1
(Homo
sapiens)		4 / 4HIS A  92
GLU A  93
HIS A  96
HIS A 102
 ZN  A 210 (-3.2A)
ZN  A 210 ( 4.3A)
ZN  A 210 (-3.3A)
ZN  A 210 (-3.2A)
0.17A24.02
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1UTZ_B_HAEB1266_1
(MACROPHAGE
METALLOELASTASE)		3o2x COLLAGENASE 3
(Homo
sapiens)		4 / 4HIS A1222
GLU A1223
HIS A1226
HIS A1232
 ZN  A1999 ( 3.2A)
3O2  A1801 (-2.7A)
ZN  A1999 ( 3.4A)
ZN  A1999 ( 3.2A)
0.21A56.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UTZ_B_HAEB1266_1
(MACROPHAGE
METALLOELASTASE)		3q2h A DISINTEGRIN AND
METALLOPROTEINASE
WITH THROMBOSPONDIN
MOTIFS 1
(Homo
sapiens)		4 / 4HIS A 149
GLU A 150
HIS A 153
HIS A 159
 ZN  A 401 ( 3.3A)
QHF  A   1 (-2.6A)
QHF  A   1 ( 3.0A)
ZN  A 401 ( 3.2A)
0.20A18.48
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1UTZ_B_HAEB1266_1
(MACROPHAGE
METALLOELASTASE)		3shi INTERSTITIAL
COLLAGENASE
(Homo
sapiens)		4 / 4HIS A 218
GLU A 219
HIS A 222
HIS A 228
 ZN  A 301 (-3.3A)
ZN  A 301 ( 4.7A)
ZN  A 301 (-3.4A)
ZN  A 301 (-3.3A)
0.29A58.02
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1UTZ_B_HAEB1266_1
(MACROPHAGE
METALLOELASTASE)		3v96 STROMELYSIN-2
(Homo
sapiens)		4 / 4HIS B 217
GLU B 218
HIS B 221
HIS B 227
 ZN  B 301 (-3.2A)
ZN  B 301 ( 3.9A)
ZN  B 301 (-3.3A)
ZN  B 301 (-3.2A)
0.29A58.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UTZ_B_HAEB1266_1
(MACROPHAGE
METALLOELASTASE)		4dd8 DISINTEGRIN AND
METALLOPROTEINASE
DOMAIN-CONTAINING
PROTEIN 8
(Homo
sapiens)		4 / 4HIS A 334
GLU A 335
HIS A 338
HIS A 344
 ZN  A1002 ( 3.3A)
BAT  A1000 (-2.7A)
ZN  A1002 (-3.3A)
ZN  A1002 ( 3.3A)
0.43A20.63
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1UTZ_B_HAEB1266_1
(MACROPHAGE
METALLOELASTASE)		4gr8 MACROPHAGE
METALLOELASTASE
(Homo
sapiens)		4 / 4HIS A 218
GLU A 219
HIS A 222
HIS A 228
R4C  A 306 ( 3.2A)
R4C  A 306 (-2.7A)
ZN  A 301 ( 3.2A)
ZN  A 301 ( 3.2A)
0.20A99.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UTZ_B_HAEB1266_1
(MACROPHAGE
METALLOELASTASE)		4gwn MEPRIN A SUBUNIT
BETA
(Homo
sapiens)		4 / 4HIS A 152
GLU A 153
HIS A 156
HIS A 162
 CD  A 701 (-3.7A)
CD  A 701 (-3.5A)
CD  A 701 (-3.7A)
CD  A 701 (-3.7A)
0.30A14.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UTZ_B_HAEB1266_1
(MACROPHAGE
METALLOELASTASE)		4qgn 1,2-DIHYDROXY-3-KETO
-5-METHYLTHIOPENTENE
DIOXYGENASE
(Homo
sapiens)		4 / 4HIS A 133
GLU A  94
HIS A  90
HIS A  88
 FE  A 201 (-3.3A)
FE  A 201 ( 2.7A)
FE  A 201 (-3.3A)
FE  A 201 (-3.4A)
1.08A20.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UTZ_B_HAEB1266_1
(MACROPHAGE
METALLOELASTASE)		4wk7 A DISINTEGRIN AND
METALLOPROTEINASE
WITH THROMBOSPONDIN
MOTIFS 4
(Homo
sapiens)		4 / 4HIS A 361
GLU A 362
HIS A 365
HIS A 371
 ZN  A 501 ( 3.2A)
3PQ  A 505 (-2.6A)
ZN  A 501 ( 3.3A)
ZN  A 501 ( 3.2A)
0.24A20.69
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1UTZ_B_HAEB1266_1
(MACROPHAGE
METALLOELASTASE)		4xct MATRIX
METALLOPROTEINASE-9,
MATRIX
METALLOPROTEINASE-9
(Homo
sapiens)		4 / 4HIS A 226
GLU A 227
HIS A 230
HIS A 236
 ZN  A 302 ( 3.2A)
N73  A 301 (-2.5A)
ZN  A 302 ( 3.3A)
ZN  A 302 ( 3.3A)
0.10A50.31
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1UTZ_B_HAEB1266_1
(MACROPHAGE
METALLOELASTASE)		5h0u MATRIX
METALLOPROTEINASE-14
(Homo
sapiens)		4 / 4HIS A 239
GLU A 240
HIS A 243
HIS A 249
 ZN  A 302 ( 3.3A)
GOL  A 311 (-4.2A)
ZN  A 302 (-3.4A)
ZN  A 302 (-3.2A)
0.15A50.59
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1UTZ_B_HAEB1266_1
(MACROPHAGE
METALLOELASTASE)		5th6 MATRIX
METALLOPROTEINASE-9,
MATRIX
METALLOPROTEINASE-9
(Homo
sapiens)		4 / 4HIS A 401
GLU A 402
HIS A 405
HIS A 411
 ZN  A 501 (-3.3A)
ZN  A 501 ( 4.2A)
ZN  A 501 (-3.2A)
ZN  A 501 (-3.1A)
0.22A40.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UTZ_B_HAEB1266_1
(MACROPHAGE
METALLOELASTASE)		6bdz DISINTEGRIN AND
METALLOPROTEINASE
DOMAIN-CONTAINING
PROTEIN 10
(Homo
sapiens)		4 / 4HIS A 383
GLU A 384
HIS A 387
HIS A 393
 ZN  A 705 (-3.3A)
ZN  A 705 (-3.8A)
ZN  A 705 (-4.0A)
ZN  A 705 (-3.2A)
0.46A20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Y93_A_HAEA301_1
(MACROPHAGE
METALLOELASTASE)		1ck7 PROTEIN (GELATINASE
A)
(Homo
sapiens)		4 / 6HIS A 193
HIS A 403
HIS A 407
HIS A 413
 ZN  A 991 ( 3.1A)
ZN  A 990 ( 3.4A)
ZN  A 990 ( 3.3A)
ZN  A 990 ( 3.4A)
0.43A26.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Y93_A_HAEA301_1
(MACROPHAGE
METALLOELASTASE)		1eak 72 KDA TYPE IV
COLLAGENASE
(Homo
sapiens)		4 / 6HIS A 193
HIS A 403
HIS A 407
HIS A 413
 ZN  A 996 (-3.1A)
ZN  A 997 (-3.5A)
ZN  A 997 (-3.6A)
ZN  A 997 (-3.5A)
0.44A26.88
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1Y93_A_HAEA301_1
(MACROPHAGE
METALLOELASTASE)		1hfs STROMELYSIN-1
(Homo
sapiens)		5 / 6HIS A 166
HIS A 201
GLU A 202
HIS A 205
HIS A 211
 ZN  A 258 ( 3.0A)
ZN  A 257 ( 3.1A)
L04  A 256 ( 2.7A)
ZN  A 257 ( 3.2A)
ZN  A 257 ( 3.1A)
0.51A58.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Y93_A_HAEA301_1
(MACROPHAGE
METALLOELASTASE)		1l6j MATRIX
METALLOPROTEINASE-9
(Homo
sapiens)		5 / 6HIS A 190
HIS A 401
GLU A 402
HIS A 405
HIS A 411
 ZN  A 501 (-3.4A)
ZN  A 500 (-3.4A)
ZN  A 500 ( 4.3A)
ZN  A 500 (-3.2A)
ZN  A 500 (-3.4A)
0.24A23.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1Y93_A_HAEA301_1
(MACROPHAGE
METALLOELASTASE)		1qib 72 KDA TYPE IV
COLLAGENASE
(Homo
sapiens)		5 / 6HIS A 166
HIS A 201
GLU A 202
HIS A 205
HIS A 211
 ZN  A 502 (-3.5A)
ZN  A 501 (-3.5A)
ZN  A 501 ( 4.5A)
ZN  A 501 (-3.5A)
ZN  A 501 (-3.5A)
0.31A59.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Y93_A_HAEA301_1
(MACROPHAGE
METALLOELASTASE)		1r55 ADAM 33
(Homo
sapiens)		4 / 6HIS A 345
GLU A 346
HIS A 349
HIS A 355
 ZN  A 201 ( 3.3A)
097  A 518 (-2.9A)
ZN  A 201 ( 3.2A)
ZN  A 201 ( 3.3A)
0.29A25.33
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1Y93_A_HAEA301_1
(MACROPHAGE
METALLOELASTASE)		1rm8 MATRIX
METALLOPROTEINASE-16
(Homo
sapiens)		5 / 6HIS A 208
HIS A 246
GLU A 247
HIS A 250
HIS A 256
 ZN  A 501 (-3.2A)
ZN  A 500 ( 3.3A)
BAT  A 800 (-2.7A)
ZN  A 500 ( 3.2A)
ZN  A 500 ( 3.3A)
0.18A50.89
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1Y93_A_HAEA301_1
(MACROPHAGE
METALLOELASTASE)		1slm STROMELYSIN-1
(Homo
sapiens)		5 / 6HIS A 166
HIS A 201
GLU A 202
HIS A 205
HIS A 211
 ZN  A 258 ( 3.0A)
ZN  A 257 ( 3.0A)
ZN  A 257 ( 4.1A)
ZN  A 257 ( 3.2A)
ZN  A 257 ( 3.1A)
0.25A41.45
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1Y93_A_HAEA301_1
(MACROPHAGE
METALLOELASTASE)		1su3 INTERSTITIAL
COLLAGENASE
(Homo
sapiens)		4 / 6HIS A 183
HIS A 218
HIS A 222
HIS A 228
 ZN  A 915 (-3.3A)
ZN  A 913 (-3.2A)
ZN  A 913 (-3.2A)
ZN  A 913 (-3.2A)
0.16A38.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Y93_A_HAEA301_1
(MACROPHAGE
METALLOELASTASE)		1xcr HYPOTHETICAL PROTEIN
PTD012
(Homo
sapiens)		4 / 6HIS A 268
GLU A 110
HIS A 278
HIS A 266
 ZN  A1001 ( 3.2A)
ACY  A2001 ( 3.7A)
ZN  A1001 ( 3.2A)
ZN  A1001 ( 3.2A)
0.97A21.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Y93_A_HAEA301_1
(MACROPHAGE
METALLOELASTASE)		2fv5 ADAM 17
(Homo
sapiens)		4 / 6HIS A 405
GLU A 406
HIS A 409
HIS A 415
 ZN  A   3 ( 3.2A)
541  A   1 (-2.6A)
ZN  A   3 ( 3.3A)
ZN  A   3 ( 3.2A)
0.26A23.08
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1Y93_A_HAEA301_1
(MACROPHAGE
METALLOELASTASE)		2jsd MATRIX
METALLOPROTEINASE-20
(Homo
sapiens)		5 / 6HIS A 191
HIS A 226
GLU A 227
HIS A 230
HIS A 236
 ZN  A 275 (-3.4A)
NGH  A 277 ( 3.0A)
NGH  A 277 (-3.6A)
ZN  A 276 ( 3.3A)
ZN  A 276 ( 3.0A)
0.78A54.09
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1Y93_A_HAEA301_1
(MACROPHAGE
METALLOELASTASE)		2oy4 NEUTROPHIL
COLLAGENASE
(Homo
sapiens)		5 / 6HIS A 162
HIS A 197
GLU A 198
HIS A 201
HIS A 207
 ZN  A 998 (-3.3A)
ZN  A 999 (-3.2A)
ZN  A 999 ( 4.4A)
ZN  A 999 (-3.4A)
ZN  A 999 (-3.2A)
0.19A53.46
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1Y93_A_HAEA301_1
(MACROPHAGE
METALLOELASTASE)		2oy4 NEUTROPHIL
COLLAGENASE
(Homo
sapiens)		5 / 6ILE A 159
HIS A 162
GLU A 198
HIS A 201
HIS A 207
None
ZN  A 998 (-3.3A)
ZN  A 999 ( 4.4A)
ZN  A 999 (-3.4A)
ZN  A 999 (-3.2A)
0.58A53.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Y93_A_HAEA301_1
(MACROPHAGE
METALLOELASTASE)		2rjq ADAMTS-5
(Homo
sapiens)		4 / 6HIS A 410
GLU A 411
HIS A 414
HIS A 420
 ZN  A   1 ( 3.2A)
BAT  A 559 (-2.5A)
ZN  A   1 ( 3.3A)
ZN  A   1 ( 3.3A)
0.16A15.80
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1Y93_A_HAEA301_1
(MACROPHAGE
METALLOELASTASE)		2y6c MATRILYSIN
(Homo
sapiens)		5 / 6HIS A 183
HIS A 219
GLU A 220
HIS A 223
HIS A 229
 ZN  A1266 ( 3.3A)
ZN  A1267 ( 3.2A)
TQI  A1269 (-2.9A)
ZN  A1267 ( 3.3A)
ZN  A1267 ( 3.2A)
0.35A53.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Y93_A_HAEA301_1
(MACROPHAGE
METALLOELASTASE)		3b8z PROTEIN ADAMTS-5
(Homo
sapiens)		4 / 6HIS A 410
GLU A 411
HIS A 414
HIS A 420
 ZN  A 901 ( 3.2A)
294  A 801 (-2.7A)
ZN  A 901 ( 3.3A)
ZN  A 901 ( 3.3A)
0.11A23.72
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1Y93_A_HAEA301_1
(MACROPHAGE
METALLOELASTASE)		3ba0 MACROPHAGE
METALLOELASTASE
(Homo
sapiens)		6 / 6ILE A 180
HIS A 183
HIS A 218
GLU A 219
HIS A 222
HIS A 228
None
ZN  A 472 (-3.1A)
ZN  A 471 (-4.0A)
ZN  A 471 ( 3.2A)
HAE  A 477 ( 3.1A)
ZN  A 471 (-3.7A)
0.80A100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Y93_A_HAEA301_1
(MACROPHAGE
METALLOELASTASE)		3edi TOLLOID-LIKE PROTEIN
1
(Homo
sapiens)		4 / 6HIS A  92
GLU A  93
HIS A  96
HIS A 102
 ZN  A 210 (-3.2A)
ZN  A 210 ( 4.3A)
ZN  A 210 (-3.3A)
ZN  A 210 (-3.2A)
0.16A23.12
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1Y93_A_HAEA301_1
(MACROPHAGE
METALLOELASTASE)		3o2x COLLAGENASE 3
(Homo
sapiens)		5 / 6HIS A1187
HIS A1222
GLU A1223
HIS A1226
HIS A1232
 ZN  A1998 ( 3.2A)
ZN  A1999 ( 3.2A)
3O2  A1801 (-2.7A)
ZN  A1999 ( 3.4A)
ZN  A1999 ( 3.2A)
0.25A56.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Y93_A_HAEA301_1
(MACROPHAGE
METALLOELASTASE)		3q2h A DISINTEGRIN AND
METALLOPROTEINASE
WITH THROMBOSPONDIN
MOTIFS 1
(Homo
sapiens)		4 / 6HIS A 149
GLU A 150
HIS A 153
HIS A 159
 ZN  A 401 ( 3.3A)
QHF  A   1 (-2.6A)
QHF  A   1 ( 3.0A)
ZN  A 401 ( 3.2A)
0.19A18.87
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1Y93_A_HAEA301_1
(MACROPHAGE
METALLOELASTASE)		3shi INTERSTITIAL
COLLAGENASE
(Homo
sapiens)		5 / 6HIS A 183
HIS A 218
GLU A 219
HIS A 222
HIS A 228
 ZN  A 302 (-3.1A)
ZN  A 301 (-3.3A)
ZN  A 301 ( 4.7A)
ZN  A 301 (-3.4A)
ZN  A 301 (-3.3A)
0.30A57.67
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1Y93_A_HAEA301_1
(MACROPHAGE
METALLOELASTASE)		3v96 STROMELYSIN-2
(Homo
sapiens)		5 / 6HIS B 182
HIS B 217
GLU B 218
HIS B 221
HIS B 227
 ZN  B 302 (-3.2A)
ZN  B 301 (-3.2A)
ZN  B 301 ( 3.9A)
ZN  B 301 (-3.3A)
ZN  B 301 (-3.2A)
0.28A55.76
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1Y93_A_HAEA301_1
(MACROPHAGE
METALLOELASTASE)		4auo INTERSTITIAL
COLLAGENASE
(Homo
sapiens)		4 / 6HIS A 164
HIS A 199
HIS A 203
HIS A 209
 ZN  A1201 (-3.1A)
ZN  A1202 (-3.0A)
ZN  A1202 (-3.1A)
ZN  A1202 (-3.4A)
0.14A55.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Y93_A_HAEA301_1
(MACROPHAGE
METALLOELASTASE)		4dd8 DISINTEGRIN AND
METALLOPROTEINASE
DOMAIN-CONTAINING
PROTEIN 8
(Homo
sapiens)		4 / 6HIS A 334
GLU A 335
HIS A 338
HIS A 344
 ZN  A1002 ( 3.3A)
BAT  A1000 (-2.7A)
ZN  A1002 (-3.3A)
ZN  A1002 ( 3.3A)
0.40A18.52
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1Y93_A_HAEA301_1
(MACROPHAGE
METALLOELASTASE)		4fvl COLLAGENASE 3
(Homo
sapiens)		4 / 6HIS A 187
HIS A 222
HIS A 226
HIS A 232
 ZN  A 502 (-3.3A)
ZN  A 501 (-3.3A)
ZN  A 501 (-3.1A)
ZN  A 501 (-3.2A)
0.36A55.49
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1Y93_A_HAEA301_1
(MACROPHAGE
METALLOELASTASE)		4gr8 MACROPHAGE
METALLOELASTASE
(Homo
sapiens)		6 / 6ILE A 180
HIS A 183
HIS A 218
GLU A 219
HIS A 222
HIS A 228
R4C  A 306 (-4.3A)
ZN  A 302 (-3.2A)
R4C  A 306 ( 3.2A)
R4C  A 306 (-2.7A)
ZN  A 301 ( 3.2A)
ZN  A 301 ( 3.2A)
0.30A100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Y93_A_HAEA301_1
(MACROPHAGE
METALLOELASTASE)		4gwn MEPRIN A SUBUNIT
BETA
(Homo
sapiens)		4 / 6HIS A 152
GLU A 153
HIS A 156
HIS A 162
 CD  A 701 (-3.7A)
CD  A 701 (-3.5A)
CD  A 701 (-3.7A)
CD  A 701 (-3.7A)
0.29A13.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Y93_A_HAEA301_1
(MACROPHAGE
METALLOELASTASE)		4wk7 A DISINTEGRIN AND
METALLOPROTEINASE
WITH THROMBOSPONDIN
MOTIFS 4
(Homo
sapiens)		4 / 6HIS A 361
GLU A 362
HIS A 365
HIS A 371
 ZN  A 501 ( 3.2A)
3PQ  A 505 (-2.6A)
ZN  A 501 ( 3.3A)
ZN  A 501 ( 3.2A)
0.24A19.67
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1Y93_A_HAEA301_1
(MACROPHAGE
METALLOELASTASE)		4xct MATRIX
METALLOPROTEINASE-9,
MATRIX
METALLOPROTEINASE-9
(Homo
sapiens)		5 / 6HIS A 190
HIS A 226
GLU A 227
HIS A 230
HIS A 236
 ZN  A 303 ( 3.2A)
ZN  A 302 ( 3.2A)
N73  A 301 (-2.5A)
ZN  A 302 ( 3.3A)
ZN  A 302 ( 3.3A)
0.16A50.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1Y93_A_HAEA301_1
(MACROPHAGE
METALLOELASTASE)		5h0u MATRIX
METALLOPROTEINASE-14
(Homo
sapiens)		5 / 6HIS A 201
HIS A 239
GLU A 240
HIS A 243
HIS A 249
 ZN  A 303 (-3.2A)
ZN  A 302 ( 3.3A)
GOL  A 311 (-4.2A)
ZN  A 302 (-3.4A)
ZN  A 302 (-3.2A)
0.38A50.89
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1Y93_A_HAEA301_1
(MACROPHAGE
METALLOELASTASE)		5th6 MATRIX
METALLOPROTEINASE-9,
MATRIX
METALLOPROTEINASE-9
(Homo
sapiens)		5 / 6HIS A 190
HIS A 401
GLU A 402
HIS A 405
HIS A 411
 ZN  A 502 (-3.2A)
ZN  A 501 (-3.3A)
ZN  A 501 ( 4.2A)
ZN  A 501 (-3.2A)
ZN  A 501 (-3.1A)
0.21A35.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Y93_A_HAEA301_1
(MACROPHAGE
METALLOELASTASE)		6bdz DISINTEGRIN AND
METALLOPROTEINASE
DOMAIN-CONTAINING
PROTEIN 10
(Homo
sapiens)		4 / 6HIS A 383
GLU A 384
HIS A 387
HIS A 393
 ZN  A 705 (-3.3A)
ZN  A 705 (-3.8A)
ZN  A 705 (-4.0A)
ZN  A 705 (-3.2A)
0.49A19.87
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2HU6_A_HAEA269_1
(MACROPHAGE
METALLOELASTASE)		1hfs STROMELYSIN-1
(Homo
sapiens)		4 / 4HIS A 201
GLU A 202
HIS A 205
HIS A 211
 ZN  A 257 ( 3.1A)
L04  A 256 ( 2.7A)
ZN  A 257 ( 3.2A)
ZN  A 257 ( 3.1A)
0.19A58.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HU6_A_HAEA269_1
(MACROPHAGE
METALLOELASTASE)		1l6j MATRIX
METALLOPROTEINASE-9
(Homo
sapiens)		4 / 4HIS A 401
GLU A 402
HIS A 405
HIS A 411
 ZN  A 500 (-3.4A)
ZN  A 500 ( 4.3A)
ZN  A 500 (-3.2A)
ZN  A 500 (-3.4A)
0.22A23.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2HU6_A_HAEA269_1
(MACROPHAGE
METALLOELASTASE)		1qib 72 KDA TYPE IV
COLLAGENASE
(Homo
sapiens)		4 / 4HIS A 201
GLU A 202
HIS A 205
HIS A 211
 ZN  A 501 (-3.5A)
ZN  A 501 ( 4.5A)
ZN  A 501 (-3.5A)
ZN  A 501 (-3.5A)
0.27A59.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HU6_A_HAEA269_1
(MACROPHAGE
METALLOELASTASE)		1r55 ADAM 33
(Homo
sapiens)		4 / 4HIS A 345
GLU A 346
HIS A 349
HIS A 355
 ZN  A 201 ( 3.3A)
097  A 518 (-2.9A)
ZN  A 201 ( 3.2A)
ZN  A 201 ( 3.3A)
0.26A25.33
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2HU6_A_HAEA269_1
(MACROPHAGE
METALLOELASTASE)		1rm8 MATRIX
METALLOPROTEINASE-16
(Homo
sapiens)		4 / 4HIS A 246
GLU A 247
HIS A 250
HIS A 256
 ZN  A 500 ( 3.3A)
BAT  A 800 (-2.7A)
ZN  A 500 ( 3.2A)
ZN  A 500 ( 3.3A)
0.15A50.89
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2HU6_A_HAEA269_1
(MACROPHAGE
METALLOELASTASE)		1slm STROMELYSIN-1
(Homo
sapiens)		4 / 4HIS A 201
GLU A 202
HIS A 205
HIS A 211
 ZN  A 257 ( 3.0A)
ZN  A 257 ( 4.1A)
ZN  A 257 ( 3.2A)
ZN  A 257 ( 3.1A)
0.24A41.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HU6_A_HAEA269_1
(MACROPHAGE
METALLOELASTASE)		1xcr HYPOTHETICAL PROTEIN
PTD012
(Homo
sapiens)		4 / 4HIS A 268
GLU A 110
HIS A 278
HIS A 266
 ZN  A1001 ( 3.2A)
ACY  A2001 ( 3.7A)
ZN  A1001 ( 3.2A)
ZN  A1001 ( 3.2A)
0.95A21.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HU6_A_HAEA269_1
(MACROPHAGE
METALLOELASTASE)		2fv5 ADAM 17
(Homo
sapiens)		4 / 4HIS A 405
GLU A 406
HIS A 409
HIS A 415
 ZN  A   3 ( 3.2A)
541  A   1 (-2.6A)
ZN  A   3 ( 3.3A)
ZN  A   3 ( 3.2A)
0.22A23.08
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2HU6_A_HAEA269_1
(MACROPHAGE
METALLOELASTASE)		2jsd MATRIX
METALLOPROTEINASE-20
(Homo
sapiens)		4 / 4HIS A 226
GLU A 227
HIS A 230
HIS A 236
NGH  A 277 ( 3.0A)
NGH  A 277 (-3.6A)
ZN  A 276 ( 3.3A)
ZN  A 276 ( 3.0A)
0.65A54.09
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2HU6_A_HAEA269_1
(MACROPHAGE
METALLOELASTASE)		2oy4 NEUTROPHIL
COLLAGENASE
(Homo
sapiens)		4 / 4HIS A 197
GLU A 198
HIS A 201
HIS A 207
 ZN  A 999 (-3.2A)
ZN  A 999 ( 4.4A)
ZN  A 999 (-3.4A)
ZN  A 999 (-3.2A)
0.13A53.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HU6_A_HAEA269_1
(MACROPHAGE
METALLOELASTASE)		2rjq ADAMTS-5
(Homo
sapiens)		4 / 4HIS A 410
GLU A 411
HIS A 414
HIS A 420
 ZN  A   1 ( 3.2A)
BAT  A 559 (-2.5A)
ZN  A   1 ( 3.3A)
ZN  A   1 ( 3.3A)
0.12A15.80
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2HU6_A_HAEA269_1
(MACROPHAGE
METALLOELASTASE)		2y6c MATRILYSIN
(Homo
sapiens)		4 / 4HIS A 219
GLU A 220
HIS A 223
HIS A 229
 ZN  A1267 ( 3.2A)
TQI  A1269 (-2.9A)
ZN  A1267 ( 3.3A)
ZN  A1267 ( 3.2A)
0.17A53.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HU6_A_HAEA269_1
(MACROPHAGE
METALLOELASTASE)		3b8z PROTEIN ADAMTS-5
(Homo
sapiens)		4 / 4HIS A 410
GLU A 411
HIS A 414
HIS A 420
 ZN  A 901 ( 3.2A)
294  A 801 (-2.7A)
ZN  A 901 ( 3.3A)
ZN  A 901 ( 3.3A)
0.14A23.72
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2HU6_A_HAEA269_1
(MACROPHAGE
METALLOELASTASE)		3ba0 MACROPHAGE
METALLOELASTASE
(Homo
sapiens)		4 / 4HIS A 218
GLU A 219
HIS A 222
HIS A 228
 ZN  A 471 (-4.0A)
ZN  A 471 ( 3.2A)
HAE  A 477 ( 3.1A)
ZN  A 471 (-3.7A)
0.41A100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HU6_A_HAEA269_1
(MACROPHAGE
METALLOELASTASE)		3edi TOLLOID-LIKE PROTEIN
1
(Homo
sapiens)		4 / 4HIS A  92
GLU A  93
HIS A  96
HIS A 102
 ZN  A 210 (-3.2A)
ZN  A 210 ( 4.3A)
ZN  A 210 (-3.3A)
ZN  A 210 (-3.2A)
0.17A23.12
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2HU6_A_HAEA269_1
(MACROPHAGE
METALLOELASTASE)		3o2x COLLAGENASE 3
(Homo
sapiens)		4 / 4HIS A1222
GLU A1223
HIS A1226
HIS A1232
 ZN  A1999 ( 3.2A)
3O2  A1801 (-2.7A)
ZN  A1999 ( 3.4A)
ZN  A1999 ( 3.2A)
0.22A56.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HU6_A_HAEA269_1
(MACROPHAGE
METALLOELASTASE)		3q2h A DISINTEGRIN AND
METALLOPROTEINASE
WITH THROMBOSPONDIN
MOTIFS 1
(Homo
sapiens)		4 / 4HIS A 149
GLU A 150
HIS A 153
HIS A 159
 ZN  A 401 ( 3.3A)
QHF  A   1 (-2.6A)
QHF  A   1 ( 3.0A)
ZN  A 401 ( 3.2A)
0.15A18.87
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2HU6_A_HAEA269_1
(MACROPHAGE
METALLOELASTASE)		3shi INTERSTITIAL
COLLAGENASE
(Homo
sapiens)		4 / 4HIS A 218
GLU A 219
HIS A 222
HIS A 228
 ZN  A 301 (-3.3A)
ZN  A 301 ( 4.7A)
ZN  A 301 (-3.4A)
ZN  A 301 (-3.3A)
0.23A57.67
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2HU6_A_HAEA269_1
(MACROPHAGE
METALLOELASTASE)		3v96 STROMELYSIN-2
(Homo
sapiens)		4 / 4HIS B 217
GLU B 218
HIS B 221
HIS B 227
 ZN  B 301 (-3.2A)
ZN  B 301 ( 3.9A)
ZN  B 301 (-3.3A)
ZN  B 301 (-3.2A)
0.26A55.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HU6_A_HAEA269_1
(MACROPHAGE
METALLOELASTASE)		4dd8 DISINTEGRIN AND
METALLOPROTEINASE
DOMAIN-CONTAINING
PROTEIN 8
(Homo
sapiens)		4 / 4HIS A 334
GLU A 335
HIS A 338
HIS A 344
 ZN  A1002 ( 3.3A)
BAT  A1000 (-2.7A)
ZN  A1002 (-3.3A)
ZN  A1002 ( 3.3A)
0.37A18.52
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2HU6_A_HAEA269_1
(MACROPHAGE
METALLOELASTASE)		4gr8 MACROPHAGE
METALLOELASTASE
(Homo
sapiens)		4 / 4HIS A 218
GLU A 219
HIS A 222
HIS A 228
R4C  A 306 ( 3.2A)
R4C  A 306 (-2.7A)
ZN  A 301 ( 3.2A)
ZN  A 301 ( 3.2A)
0.20A100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HU6_A_HAEA269_1
(MACROPHAGE
METALLOELASTASE)		4gwn MEPRIN A SUBUNIT
BETA
(Homo
sapiens)		4 / 4HIS A 152
GLU A 153
HIS A 156
HIS A 162
 CD  A 701 (-3.7A)
CD  A 701 (-3.5A)
CD  A 701 (-3.7A)
CD  A 701 (-3.7A)
0.29A13.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HU6_A_HAEA269_1
(MACROPHAGE
METALLOELASTASE)		4qgn 1,2-DIHYDROXY-3-KETO
-5-METHYLTHIOPENTENE
DIOXYGENASE
(Homo
sapiens)		4 / 4HIS A 133
GLU A  94
HIS A  90
HIS A  88
 FE  A 201 (-3.3A)
FE  A 201 ( 2.7A)
FE  A 201 (-3.3A)
FE  A 201 (-3.4A)
1.03A20.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HU6_A_HAEA269_1
(MACROPHAGE
METALLOELASTASE)		4wk7 A DISINTEGRIN AND
METALLOPROTEINASE
WITH THROMBOSPONDIN
MOTIFS 4
(Homo
sapiens)		4 / 4HIS A 361
GLU A 362
HIS A 365
HIS A 371
 ZN  A 501 ( 3.2A)
3PQ  A 505 (-2.6A)
ZN  A 501 ( 3.3A)
ZN  A 501 ( 3.2A)
0.20A19.67
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2HU6_A_HAEA269_1
(MACROPHAGE
METALLOELASTASE)		4xct MATRIX
METALLOPROTEINASE-9,
MATRIX
METALLOPROTEINASE-9
(Homo
sapiens)		4 / 4HIS A 226
GLU A 227
HIS A 230
HIS A 236
 ZN  A 302 ( 3.2A)
N73  A 301 (-2.5A)
ZN  A 302 ( 3.3A)
ZN  A 302 ( 3.3A)
0.08A50.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2HU6_A_HAEA269_1
(MACROPHAGE
METALLOELASTASE)		5h0u MATRIX
METALLOPROTEINASE-14
(Homo
sapiens)		4 / 4HIS A 239
GLU A 240
HIS A 243
HIS A 249
 ZN  A 302 ( 3.3A)
GOL  A 311 (-4.2A)
ZN  A 302 (-3.4A)
ZN  A 302 (-3.2A)
0.11A50.89
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2HU6_A_HAEA269_1
(MACROPHAGE
METALLOELASTASE)		5th6 MATRIX
METALLOPROTEINASE-9,
MATRIX
METALLOPROTEINASE-9
(Homo
sapiens)		4 / 4HIS A 401
GLU A 402
HIS A 405
HIS A 411
 ZN  A 501 (-3.3A)
ZN  A 501 ( 4.2A)
ZN  A 501 (-3.2A)
ZN  A 501 (-3.1A)
0.19A35.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HU6_A_HAEA269_1
(MACROPHAGE
METALLOELASTASE)		6bdz DISINTEGRIN AND
METALLOPROTEINASE
DOMAIN-CONTAINING
PROTEIN 10
(Homo
sapiens)		4 / 4HIS A 383
GLU A 384
HIS A 387
HIS A 393
 ZN  A 705 (-3.3A)
ZN  A 705 (-3.8A)
ZN  A 705 (-4.0A)
ZN  A 705 (-3.2A)
0.48A19.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OW9_A_HAEA502_1
(COLLAGENASE 3)		1ck7 PROTEIN (GELATINASE
A)
(Homo
sapiens)		4 / 6HIS A 193
HIS A 403
HIS A 407
HIS A 413
 ZN  A 991 ( 3.1A)
ZN  A 990 ( 3.4A)
ZN  A 990 ( 3.3A)
ZN  A 990 ( 3.4A)
0.43A22.66
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2OW9_A_HAEA502_1
(COLLAGENASE 3)		1eak 72 KDA TYPE IV
COLLAGENASE
(Homo
sapiens)		4 / 6HIS A 193
HIS A 403
HIS A 407
HIS A 413
 ZN  A 996 (-3.1A)
ZN  A 997 (-3.5A)
ZN  A 997 (-3.6A)
ZN  A 997 (-3.5A)
0.38A30.42
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2OW9_A_HAEA502_1
(COLLAGENASE 3)		1hfs STROMELYSIN-1
(Homo
sapiens)		5 / 6HIS A 166
HIS A 201
GLU A 202
HIS A 205
HIS A 211
 ZN  A 258 ( 3.0A)
ZN  A 257 ( 3.1A)
L04  A 256 ( 2.7A)
ZN  A 257 ( 3.2A)
ZN  A 257 ( 3.1A)
0.64A60.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OW9_A_HAEA502_1
(COLLAGENASE 3)		1l6j MATRIX
METALLOPROTEINASE-9
(Homo
sapiens)		5 / 6HIS A 190
HIS A 401
GLU A 402
HIS A 405
HIS A 411
 ZN  A 501 (-3.4A)
ZN  A 500 (-3.4A)
ZN  A 500 ( 4.3A)
ZN  A 500 (-3.2A)
ZN  A 500 (-3.4A)
0.34A24.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OW9_A_HAEA502_1
(COLLAGENASE 3)		1l6j MATRIX
METALLOPROTEINASE-9
(Homo
sapiens)		5 / 6LEU A 187
HIS A 190
HIS A 401
GLU A 402
HIS A 411
None
ZN  A 501 (-3.4A)
ZN  A 500 (-3.4A)
ZN  A 500 ( 4.3A)
ZN  A 500 (-3.4A)
0.69A24.36
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2OW9_A_HAEA502_1
(COLLAGENASE 3)		1qib 72 KDA TYPE IV
COLLAGENASE
(Homo
sapiens)		6 / 6LEU A 163
HIS A 166
HIS A 201
GLU A 202
HIS A 205
HIS A 211
None
ZN  A 502 (-3.5A)
ZN  A 501 (-3.5A)
ZN  A 501 ( 4.5A)
ZN  A 501 (-3.5A)
ZN  A 501 (-3.5A)
0.67A65.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OW9_A_HAEA502_1
(COLLAGENASE 3)		1r55 ADAM 33
(Homo
sapiens)		4 / 6HIS A 345
GLU A 346
HIS A 349
HIS A 355
 ZN  A 201 ( 3.3A)
097  A 518 (-2.9A)
ZN  A 201 ( 3.2A)
ZN  A 201 ( 3.3A)
0.39A24.32
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2OW9_A_HAEA502_1
(COLLAGENASE 3)		1rm8 MATRIX
METALLOPROTEINASE-16
(Homo
sapiens)		5 / 6HIS A 208
HIS A 246
GLU A 247
HIS A 250
HIS A 256
 ZN  A 501 (-3.2A)
ZN  A 500 ( 3.3A)
BAT  A 800 (-2.7A)
ZN  A 500 ( 3.2A)
ZN  A 500 ( 3.3A)
0.27A47.75
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2OW9_A_HAEA502_1
(COLLAGENASE 3)		1slm STROMELYSIN-1
(Homo
sapiens)		5 / 6HIS A 166
HIS A 201
GLU A 202
HIS A 205
HIS A 211
 ZN  A 258 ( 3.0A)
ZN  A 257 ( 3.0A)
ZN  A 257 ( 4.1A)
ZN  A 257 ( 3.2A)
ZN  A 257 ( 3.1A)
0.32A43.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OW9_A_HAEA502_1
(COLLAGENASE 3)		1su3 INTERSTITIAL
COLLAGENASE
(Homo
sapiens)		4 / 6HIS A 183
HIS A 218
HIS A 222
HIS A 228
 ZN  A 915 (-3.3A)
ZN  A 913 (-3.2A)
ZN  A 913 (-3.2A)
ZN  A 913 (-3.2A)
0.33A27.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OW9_A_HAEA502_1
(COLLAGENASE 3)		1xcr HYPOTHETICAL PROTEIN
PTD012
(Homo
sapiens)		5 / 6LEU A  68
HIS A 268
GLU A 110
HIS A 278
HIS A 266
None
ZN  A1001 ( 3.2A)
ACY  A2001 ( 3.7A)
ZN  A1001 ( 3.2A)
ZN  A1001 ( 3.2A)
1.15A19.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OW9_A_HAEA502_1
(COLLAGENASE 3)		2fv5 ADAM 17
(Homo
sapiens)		4 / 6HIS A 405
GLU A 406
HIS A 409
HIS A 415
 ZN  A   3 ( 3.2A)
541  A   1 (-2.6A)
ZN  A   3 ( 3.3A)
ZN  A   3 ( 3.2A)
0.33A22.64
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2OW9_A_HAEA502_1
(COLLAGENASE 3)		2jsd MATRIX
METALLOPROTEINASE-20
(Homo
sapiens)		5 / 6HIS A 191
HIS A 226
GLU A 227
HIS A 230
HIS A 236
 ZN  A 275 (-3.4A)
NGH  A 277 ( 3.0A)
NGH  A 277 (-3.6A)
ZN  A 276 ( 3.3A)
ZN  A 276 ( 3.0A)
0.66A57.14
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2OW9_A_HAEA502_1
(COLLAGENASE 3)		2oy4 NEUTROPHIL
COLLAGENASE
(Homo
sapiens)		5 / 6HIS A 162
HIS A 197
GLU A 198
HIS A 201
HIS A 207
 ZN  A 998 (-3.3A)
ZN  A 999 (-3.2A)
ZN  A 999 ( 4.4A)
ZN  A 999 (-3.4A)
ZN  A 999 (-3.2A)
0.32A60.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OW9_A_HAEA502_1
(COLLAGENASE 3)		2rjq ADAMTS-5
(Homo
sapiens)		4 / 6HIS A 410
GLU A 411
HIS A 414
HIS A 420
 ZN  A   1 ( 3.2A)
BAT  A 559 (-2.5A)
ZN  A   1 ( 3.3A)
ZN  A   1 ( 3.3A)
0.19A19.14
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2OW9_A_HAEA502_1
(COLLAGENASE 3)		2y6c MATRILYSIN
(Homo
sapiens)		5 / 6HIS A 183
HIS A 219
GLU A 220
HIS A 223
HIS A 229
 ZN  A1266 ( 3.3A)
ZN  A1267 ( 3.2A)
TQI  A1269 (-2.9A)
ZN  A1267 ( 3.3A)
ZN  A1267 ( 3.2A)
0.47A51.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OW9_A_HAEA502_1
(COLLAGENASE 3)		3b8z PROTEIN ADAMTS-5
(Homo
sapiens)		4 / 6HIS A 410
GLU A 411
HIS A 414
HIS A 420
 ZN  A 901 ( 3.2A)
294  A 801 (-2.7A)
ZN  A 901 ( 3.3A)
ZN  A 901 ( 3.3A)
0.20A23.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OW9_A_HAEA502_1
(COLLAGENASE 3)		3ba0 MACROPHAGE
METALLOELASTASE
(Homo
sapiens)		5 / 6HIS A 183
HIS A 218
GLU A 219
HIS A 222
HIS A 228
 ZN  A 472 (-3.1A)
ZN  A 471 (-4.0A)
ZN  A 471 ( 3.2A)
HAE  A 477 ( 3.1A)
ZN  A 471 (-3.7A)
0.68A28.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OW9_A_HAEA502_1
(COLLAGENASE 3)		3edi TOLLOID-LIKE PROTEIN
1
(Homo
sapiens)		4 / 6HIS A  92
GLU A  93
HIS A  96
HIS A 102
 ZN  A 210 (-3.2A)
ZN  A 210 ( 4.3A)
ZN  A 210 (-3.3A)
ZN  A 210 (-3.2A)
0.11A23.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OW9_A_HAEA502_1
(COLLAGENASE 3)		3lgg ADENOSINE DEAMINASE
CECR1
(Homo
sapiens)		4 / 6LEU A 389
HIS A  86
HIS A  88
HIS A 330
None
ZN  A 512 (-3.4A)
CFE  A 513 ( 3.3A)
ZN  A 512 ( 3.5A)
0.91A15.21
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2OW9_A_HAEA502_1
(COLLAGENASE 3)		3o2x COLLAGENASE 3
(Homo
sapiens)		5 / 6HIS A1187
HIS A1222
GLU A1223
HIS A1226
HIS A1232
 ZN  A1998 ( 3.2A)
ZN  A1999 ( 3.2A)
3O2  A1801 (-2.7A)
ZN  A1999 ( 3.4A)
ZN  A1999 ( 3.2A)
0.34A98.80
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2OW9_A_HAEA502_1
(COLLAGENASE 3)		3o2x COLLAGENASE 3
(Homo
sapiens)		5 / 6LEU A1184
HIS A1187
HIS A1222
HIS A1226
HIS A1232
3O2  A1801 ( 4.5A)
ZN  A1998 ( 3.2A)
ZN  A1999 ( 3.2A)
ZN  A1999 ( 3.4A)
ZN  A1999 ( 3.2A)
0.74A98.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OW9_A_HAEA502_1
(COLLAGENASE 3)		3q2h A DISINTEGRIN AND
METALLOPROTEINASE
WITH THROMBOSPONDIN
MOTIFS 1
(Homo
sapiens)		4 / 6HIS A 149
GLU A 150
HIS A 153
HIS A 159
 ZN  A 401 ( 3.3A)
QHF  A   1 (-2.6A)
QHF  A   1 ( 3.0A)
ZN  A 401 ( 3.2A)
0.23A20.77
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2OW9_A_HAEA502_1
(COLLAGENASE 3)		3shi INTERSTITIAL
COLLAGENASE
(Homo
sapiens)		5 / 6HIS A 183
HIS A 218
GLU A 219
HIS A 222
HIS A 228
 ZN  A 302 (-3.1A)
ZN  A 301 (-3.3A)
ZN  A 301 ( 4.7A)
ZN  A 301 (-3.4A)
ZN  A 301 (-3.3A)
0.47A58.28
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2OW9_A_HAEA502_1
(COLLAGENASE 3)		3v96 STROMELYSIN-2
(Homo
sapiens)		5 / 6HIS B 182
HIS B 217
GLU B 218
HIS B 221
HIS B 227
 ZN  B 302 (-3.2A)
ZN  B 301 (-3.2A)
ZN  B 301 ( 3.9A)
ZN  B 301 (-3.3A)
ZN  B 301 (-3.2A)
0.35A61.90
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2OW9_A_HAEA502_1
(COLLAGENASE 3)		4auo INTERSTITIAL
COLLAGENASE
(Homo
sapiens)		4 / 6HIS A 164
HIS A 199
HIS A 203
HIS A 209
 ZN  A1201 (-3.1A)
ZN  A1202 (-3.0A)
ZN  A1202 (-3.1A)
ZN  A1202 (-3.4A)
0.33A31.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OW9_A_HAEA502_1
(COLLAGENASE 3)		4dd8 DISINTEGRIN AND
METALLOPROTEINASE
DOMAIN-CONTAINING
PROTEIN 8
(Homo
sapiens)		4 / 6HIS A 334
GLU A 335
HIS A 338
HIS A 344
 ZN  A1002 ( 3.3A)
BAT  A1000 (-2.7A)
ZN  A1002 (-3.3A)
ZN  A1002 ( 3.3A)
0.40A22.73
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2OW9_A_HAEA502_1
(COLLAGENASE 3)		4fvl COLLAGENASE 3
(Homo
sapiens)		5 / 6LEU A 184
HIS A 187
HIS A 222
HIS A 226
HIS A 232
None
ZN  A 502 (-3.3A)
ZN  A 501 (-3.3A)
ZN  A 501 (-3.1A)
ZN  A 501 (-3.2A)
0.85A99.40
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2OW9_A_HAEA502_1
(COLLAGENASE 3)		4gr8 MACROPHAGE
METALLOELASTASE
(Homo
sapiens)		5 / 6HIS A 183
HIS A 218
GLU A 219
HIS A 222
HIS A 228
 ZN  A 302 (-3.2A)
R4C  A 306 ( 3.2A)
R4C  A 306 (-2.7A)
ZN  A 301 ( 3.2A)
ZN  A 301 ( 3.2A)
0.49A58.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OW9_A_HAEA502_1
(COLLAGENASE 3)		4gwn MEPRIN A SUBUNIT
BETA
(Homo
sapiens)		4 / 6HIS A 152
GLU A 153
HIS A 156
HIS A 162
 CD  A 701 (-3.7A)
CD  A 701 (-3.5A)
CD  A 701 (-3.7A)
CD  A 701 (-3.7A)
0.18A16.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OW9_A_HAEA502_1
(COLLAGENASE 3)		4wk7 A DISINTEGRIN AND
METALLOPROTEINASE
WITH THROMBOSPONDIN
MOTIFS 4
(Homo
sapiens)		4 / 6HIS A 361
GLU A 362
HIS A 365
HIS A 371
 ZN  A 501 ( 3.2A)
3PQ  A 505 (-2.6A)
ZN  A 501 ( 3.3A)
ZN  A 501 ( 3.2A)
0.34A25.71
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2OW9_A_HAEA502_1
(COLLAGENASE 3)		4xct MATRIX
METALLOPROTEINASE-9,
MATRIX
METALLOPROTEINASE-9
(Homo
sapiens)		5 / 6HIS A 190
HIS A 226
GLU A 227
HIS A 230
HIS A 236
 ZN  A 303 ( 3.2A)
ZN  A 302 ( 3.2A)
N73  A 301 (-2.5A)
ZN  A 302 ( 3.3A)
ZN  A 302 ( 3.3A)
0.32A60.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2OW9_A_HAEA502_1
(COLLAGENASE 3)		4xct MATRIX
METALLOPROTEINASE-9,
MATRIX
METALLOPROTEINASE-9
(Homo
sapiens)		5 / 6LEU A 187
HIS A 190
HIS A 226
HIS A 230
HIS A 236
N73  A 301 (-4.0A)
ZN  A 303 ( 3.2A)
ZN  A 302 ( 3.2A)
ZN  A 302 ( 3.3A)
ZN  A 302 ( 3.3A)
0.75A60.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2OW9_A_HAEA502_1
(COLLAGENASE 3)		5h0u MATRIX
METALLOPROTEINASE-14
(Homo
sapiens)		5 / 6HIS A 201
HIS A 239
GLU A 240
HIS A 243
HIS A 249
 ZN  A 303 (-3.2A)
ZN  A 302 ( 3.3A)
GOL  A 311 (-4.2A)
ZN  A 302 (-3.4A)
ZN  A 302 (-3.2A)
0.46A47.22
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2OW9_A_HAEA502_1
(COLLAGENASE 3)		5th6 MATRIX
METALLOPROTEINASE-9,
MATRIX
METALLOPROTEINASE-9
(Homo
sapiens)		6 / 6LEU A 187
HIS A 190
HIS A 401
GLU A 402
HIS A 405
HIS A 411
None
ZN  A 502 (-3.2A)
ZN  A 501 (-3.3A)
ZN  A 501 ( 4.2A)
ZN  A 501 (-3.2A)
ZN  A 501 (-3.1A)
0.52A43.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OW9_A_HAEA502_1
(COLLAGENASE 3)		6bdz DISINTEGRIN AND
METALLOPROTEINASE
DOMAIN-CONTAINING
PROTEIN 10
(Homo
sapiens)		4 / 6HIS A 383
GLU A 384
HIS A 387
HIS A 393
 ZN  A 705 (-3.3A)
ZN  A 705 (-3.8A)
ZN  A 705 (-4.0A)
ZN  A 705 (-3.2A)
0.38A18.67
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2OW9_B_HAEB502_1
(COLLAGENASE 3)		1hfs STROMELYSIN-1
(Homo
sapiens)		4 / 4HIS A 201
GLU A 202
HIS A 205
HIS A 211
 ZN  A 257 ( 3.1A)
L04  A 256 ( 2.7A)
ZN  A 257 ( 3.2A)
ZN  A 257 ( 3.1A)
0.28A60.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OW9_B_HAEB502_1
(COLLAGENASE 3)		1l6j MATRIX
METALLOPROTEINASE-9
(Homo
sapiens)		4 / 4HIS A 401
GLU A 402
HIS A 405
HIS A 411
 ZN  A 500 (-3.4A)
ZN  A 500 ( 4.3A)
ZN  A 500 (-3.2A)
ZN  A 500 (-3.4A)
0.19A24.36
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2OW9_B_HAEB502_1
(COLLAGENASE 3)		1qib 72 KDA TYPE IV
COLLAGENASE
(Homo
sapiens)		4 / 4HIS A 201
GLU A 202
HIS A 205
HIS A 211
 ZN  A 501 (-3.5A)
ZN  A 501 ( 4.5A)
ZN  A 501 (-3.5A)
ZN  A 501 (-3.5A)
0.31A65.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OW9_B_HAEB502_1
(COLLAGENASE 3)		1r55 ADAM 33
(Homo
sapiens)		4 / 4HIS A 345
GLU A 346
HIS A 349
HIS A 355
 ZN  A 201 ( 3.3A)
097  A 518 (-2.9A)
ZN  A 201 ( 3.2A)
ZN  A 201 ( 3.3A)
0.38A24.32
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2OW9_B_HAEB502_1
(COLLAGENASE 3)		1rm8 MATRIX
METALLOPROTEINASE-16
(Homo
sapiens)		4 / 4HIS A 246
GLU A 247
HIS A 250
HIS A 256
 ZN  A 500 ( 3.3A)
BAT  A 800 (-2.7A)
ZN  A 500 ( 3.2A)
ZN  A 500 ( 3.3A)
0.17A47.75
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2OW9_B_HAEB502_1
(COLLAGENASE 3)		1slm STROMELYSIN-1
(Homo
sapiens)		4 / 4HIS A 201
GLU A 202
HIS A 205
HIS A 211
 ZN  A 257 ( 3.0A)
ZN  A 257 ( 4.1A)
ZN  A 257 ( 3.2A)
ZN  A 257 ( 3.1A)
0.21A43.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OW9_B_HAEB502_1
(COLLAGENASE 3)		1xcr HYPOTHETICAL PROTEIN
PTD012
(Homo
sapiens)		4 / 4HIS A 268
GLU A 110
HIS A 278
HIS A 266
 ZN  A1001 ( 3.2A)
ACY  A2001 ( 3.7A)
ZN  A1001 ( 3.2A)
ZN  A1001 ( 3.2A)
1.01A19.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OW9_B_HAEB502_1
(COLLAGENASE 3)		2fv5 ADAM 17
(Homo
sapiens)		4 / 4HIS A 405
GLU A 406
HIS A 409
HIS A 415
 ZN  A   3 ( 3.2A)
541  A   1 (-2.6A)
ZN  A   3 ( 3.3A)
ZN  A   3 ( 3.2A)
0.32A22.64
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2OW9_B_HAEB502_1
(COLLAGENASE 3)		2jsd MATRIX
METALLOPROTEINASE-20
(Homo
sapiens)		4 / 4HIS A 226
GLU A 227
HIS A 230
HIS A 236
NGH  A 277 ( 3.0A)
NGH  A 277 (-3.6A)
ZN  A 276 ( 3.3A)
ZN  A 276 ( 3.0A)
0.59A57.14
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2OW9_B_HAEB502_1
(COLLAGENASE 3)		2oy4 NEUTROPHIL
COLLAGENASE
(Homo
sapiens)		4 / 4HIS A 197
GLU A 198
HIS A 201
HIS A 207
 ZN  A 999 (-3.2A)
ZN  A 999 ( 4.4A)
ZN  A 999 (-3.4A)
ZN  A 999 (-3.2A)
0.17A60.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OW9_B_HAEB502_1
(COLLAGENASE 3)		2rjq ADAMTS-5
(Homo
sapiens)		4 / 4HIS A 410
GLU A 411
HIS A 414
HIS A 420
 ZN  A   1 ( 3.2A)
BAT  A 559 (-2.5A)
ZN  A   1 ( 3.3A)
ZN  A   1 ( 3.3A)
0.19A19.14
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2OW9_B_HAEB502_1
(COLLAGENASE 3)		2y6c MATRILYSIN
(Homo
sapiens)		4 / 4HIS A 219
GLU A 220
HIS A 223
HIS A 229
 ZN  A1267 ( 3.2A)
TQI  A1269 (-2.9A)
ZN  A1267 ( 3.3A)
ZN  A1267 ( 3.2A)
0.21A51.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OW9_B_HAEB502_1
(COLLAGENASE 3)		3b8z PROTEIN ADAMTS-5
(Homo
sapiens)		4 / 4HIS A 410
GLU A 411
HIS A 414
HIS A 420
 ZN  A 901 ( 3.2A)
294  A 801 (-2.7A)
ZN  A 901 ( 3.3A)
ZN  A 901 ( 3.3A)
0.21A23.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OW9_B_HAEB502_1
(COLLAGENASE 3)		3ba0 MACROPHAGE
METALLOELASTASE
(Homo
sapiens)		4 / 4HIS A 218
GLU A 219
HIS A 222
HIS A 228
 ZN  A 471 (-4.0A)
ZN  A 471 ( 3.2A)
HAE  A 477 ( 3.1A)
ZN  A 471 (-3.7A)
0.34A28.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OW9_B_HAEB502_1
(COLLAGENASE 3)		3edi TOLLOID-LIKE PROTEIN
1
(Homo
sapiens)		4 / 4HIS A  92
GLU A  93
HIS A  96
HIS A 102
 ZN  A 210 (-3.2A)
ZN  A 210 ( 4.3A)
ZN  A 210 (-3.3A)
ZN  A 210 (-3.2A)
0.13A23.42
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2OW9_B_HAEB502_1
(COLLAGENASE 3)		3o2x COLLAGENASE 3
(Homo
sapiens)		4 / 4HIS A1222
GLU A1223
HIS A1226
HIS A1232
 ZN  A1999 ( 3.2A)
3O2  A1801 (-2.7A)
ZN  A1999 ( 3.4A)
ZN  A1999 ( 3.2A)
0.13A98.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OW9_B_HAEB502_1
(COLLAGENASE 3)		3q2h A DISINTEGRIN AND
METALLOPROTEINASE
WITH THROMBOSPONDIN
MOTIFS 1
(Homo
sapiens)		4 / 4HIS A 149
GLU A 150
HIS A 153
HIS A 159
 ZN  A 401 ( 3.3A)
QHF  A   1 (-2.6A)
QHF  A   1 ( 3.0A)
ZN  A 401 ( 3.2A)
0.20A20.77
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2OW9_B_HAEB502_1
(COLLAGENASE 3)		3shi INTERSTITIAL
COLLAGENASE
(Homo
sapiens)		4 / 4HIS A 218
GLU A 219
HIS A 222
HIS A 228
 ZN  A 301 (-3.3A)
ZN  A 301 ( 4.7A)
ZN  A 301 (-3.4A)
ZN  A 301 (-3.3A)
0.31A58.28
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2OW9_B_HAEB502_1
(COLLAGENASE 3)		3v96 STROMELYSIN-2
(Homo
sapiens)		4 / 4HIS B 217
GLU B 218
HIS B 221
HIS B 227
 ZN  B 301 (-3.2A)
ZN  B 301 ( 3.9A)
ZN  B 301 (-3.3A)
ZN  B 301 (-3.2A)
0.21A61.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OW9_B_HAEB502_1
(COLLAGENASE 3)		4dd8 DISINTEGRIN AND
METALLOPROTEINASE
DOMAIN-CONTAINING
PROTEIN 8
(Homo
sapiens)		4 / 4HIS A 334
GLU A 335
HIS A 338
HIS A 344
 ZN  A1002 ( 3.3A)
BAT  A1000 (-2.7A)
ZN  A1002 (-3.3A)
ZN  A1002 ( 3.3A)
0.40A22.73
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2OW9_B_HAEB502_1
(COLLAGENASE 3)		4gr8 MACROPHAGE
METALLOELASTASE
(Homo
sapiens)		4 / 4HIS A 218
GLU A 219
HIS A 222
HIS A 228
R4C  A 306 ( 3.2A)
R4C  A 306 (-2.7A)
ZN  A 301 ( 3.2A)
ZN  A 301 ( 3.2A)
0.29A58.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OW9_B_HAEB502_1
(COLLAGENASE 3)		4gwn MEPRIN A SUBUNIT
BETA
(Homo
sapiens)		4 / 4HIS A 152
GLU A 153
HIS A 156
HIS A 162
 CD  A 701 (-3.7A)
CD  A 701 (-3.5A)
CD  A 701 (-3.7A)
CD  A 701 (-3.7A)
0.23A16.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OW9_B_HAEB502_1
(COLLAGENASE 3)		4qgn 1,2-DIHYDROXY-3-KETO
-5-METHYLTHIOPENTENE
DIOXYGENASE
(Homo
sapiens)		4 / 4HIS A 133
GLU A  94
HIS A  90
HIS A  88
 FE  A 201 (-3.3A)
FE  A 201 ( 2.7A)
FE  A 201 (-3.3A)
FE  A 201 (-3.4A)
1.05A18.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OW9_B_HAEB502_1
(COLLAGENASE 3)		4wk7 A DISINTEGRIN AND
METALLOPROTEINASE
WITH THROMBOSPONDIN
MOTIFS 4
(Homo
sapiens)		4 / 4HIS A 361
GLU A 362
HIS A 365
HIS A 371
 ZN  A 501 ( 3.2A)
3PQ  A 505 (-2.6A)
ZN  A 501 ( 3.3A)
ZN  A 501 ( 3.2A)
0.30A25.71
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2OW9_B_HAEB502_1
(COLLAGENASE 3)		4xct MATRIX
METALLOPROTEINASE-9,
MATRIX
METALLOPROTEINASE-9
(Homo
sapiens)		4 / 4HIS A 226
GLU A 227
HIS A 230
HIS A 236
 ZN  A 302 ( 3.2A)
N73  A 301 (-2.5A)
ZN  A 302 ( 3.3A)
ZN  A 302 ( 3.3A)
0.13A60.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2OW9_B_HAEB502_1
(COLLAGENASE 3)		5h0u MATRIX
METALLOPROTEINASE-14
(Homo
sapiens)		4 / 4HIS A 239
GLU A 240
HIS A 243
HIS A 249
 ZN  A 302 ( 3.3A)
GOL  A 311 (-4.2A)
ZN  A 302 (-3.4A)
ZN  A 302 (-3.2A)
0.16A47.22
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2OW9_B_HAEB502_1
(COLLAGENASE 3)		5th6 MATRIX
METALLOPROTEINASE-9,
MATRIX
METALLOPROTEINASE-9
(Homo
sapiens)		4 / 4HIS A 401
GLU A 402
HIS A 405
HIS A 411
 ZN  A 501 (-3.3A)
ZN  A 501 ( 4.2A)
ZN  A 501 (-3.2A)
ZN  A 501 (-3.1A)
0.17A43.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OW9_B_HAEB502_1
(COLLAGENASE 3)		6bdz DISINTEGRIN AND
METALLOPROTEINASE
DOMAIN-CONTAINING
PROTEIN 10
(Homo
sapiens)		4 / 4HIS A 383
GLU A 384
HIS A 387
HIS A 393
 ZN  A 705 (-3.3A)
ZN  A 705 (-3.8A)
ZN  A 705 (-4.0A)
ZN  A 705 (-3.2A)
0.41A18.67
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2OZR_C_HAEC3001_1
(COLLAGENASE 3)		1hfs STROMELYSIN-1
(Homo
sapiens)		4 / 4HIS A 201
GLU A 202
HIS A 205
HIS A 211
 ZN  A 257 ( 3.1A)
L04  A 256 ( 2.7A)
ZN  A 257 ( 3.2A)
ZN  A 257 ( 3.1A)
0.31A60.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OZR_C_HAEC3001_1
(COLLAGENASE 3)		1l6j MATRIX
METALLOPROTEINASE-9
(Homo
sapiens)		4 / 4HIS A 401
GLU A 402
HIS A 405
HIS A 411
 ZN  A 500 (-3.4A)
ZN  A 500 ( 4.3A)
ZN  A 500 (-3.2A)
ZN  A 500 (-3.4A)
0.15A24.36
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2OZR_C_HAEC3001_1
(COLLAGENASE 3)		1qib 72 KDA TYPE IV
COLLAGENASE
(Homo
sapiens)		4 / 4HIS A 201
GLU A 202
HIS A 205
HIS A 211
 ZN  A 501 (-3.5A)
ZN  A 501 ( 4.5A)
ZN  A 501 (-3.5A)
ZN  A 501 (-3.5A)
0.32A65.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OZR_C_HAEC3001_1
(COLLAGENASE 3)		1r55 ADAM 33
(Homo
sapiens)		4 / 4HIS A 345
GLU A 346
HIS A 349
HIS A 355
 ZN  A 201 ( 3.3A)
097  A 518 (-2.9A)
ZN  A 201 ( 3.2A)
ZN  A 201 ( 3.3A)
0.41A24.32
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2OZR_C_HAEC3001_1
(COLLAGENASE 3)		1rm8 MATRIX
METALLOPROTEINASE-16
(Homo
sapiens)		4 / 4HIS A 246
GLU A 247
HIS A 250
HIS A 256
 ZN  A 500 ( 3.3A)
BAT  A 800 (-2.7A)
ZN  A 500 ( 3.2A)
ZN  A 500 ( 3.3A)
0.20A47.75
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2OZR_C_HAEC3001_1
(COLLAGENASE 3)		1slm STROMELYSIN-1
(Homo
sapiens)		4 / 4HIS A 201
GLU A 202
HIS A 205
HIS A 211
 ZN  A 257 ( 3.0A)
ZN  A 257 ( 4.1A)
ZN  A 257 ( 3.2A)
ZN  A 257 ( 3.1A)
0.21A43.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OZR_C_HAEC3001_1
(COLLAGENASE 3)		1xcr HYPOTHETICAL PROTEIN
PTD012
(Homo
sapiens)		4 / 4HIS A 268
GLU A 110
HIS A 278
HIS A 266
 ZN  A1001 ( 3.2A)
ACY  A2001 ( 3.7A)
ZN  A1001 ( 3.2A)
ZN  A1001 ( 3.2A)
0.96A19.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OZR_C_HAEC3001_1
(COLLAGENASE 3)		2fv5 ADAM 17
(Homo
sapiens)		4 / 4HIS A 405
GLU A 406
HIS A 409
HIS A 415
 ZN  A   3 ( 3.2A)
541  A   1 (-2.6A)
ZN  A   3 ( 3.3A)
ZN  A   3 ( 3.2A)
0.34A22.64
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2OZR_C_HAEC3001_1
(COLLAGENASE 3)		2jsd MATRIX
METALLOPROTEINASE-20
(Homo
sapiens)		4 / 4HIS A 226
GLU A 227
HIS A 230
HIS A 236
NGH  A 277 ( 3.0A)
NGH  A 277 (-3.6A)
ZN  A 276 ( 3.3A)
ZN  A 276 ( 3.0A)
0.54A57.14
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2OZR_C_HAEC3001_1
(COLLAGENASE 3)		2oy4 NEUTROPHIL
COLLAGENASE
(Homo
sapiens)		4 / 4HIS A 197
GLU A 198
HIS A 201
HIS A 207
 ZN  A 999 (-3.2A)
ZN  A 999 ( 4.4A)
ZN  A 999 (-3.4A)
ZN  A 999 (-3.2A)
0.17A60.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OZR_C_HAEC3001_1
(COLLAGENASE 3)		2rjq ADAMTS-5
(Homo
sapiens)		4 / 4HIS A 410
GLU A 411
HIS A 414
HIS A 420
 ZN  A   1 ( 3.2A)
BAT  A 559 (-2.5A)
ZN  A   1 ( 3.3A)
ZN  A   1 ( 3.3A)
0.22A19.14
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2OZR_C_HAEC3001_1
(COLLAGENASE 3)		2y6c MATRILYSIN
(Homo
sapiens)		4 / 4HIS A 219
GLU A 220
HIS A 223
HIS A 229
 ZN  A1267 ( 3.2A)
TQI  A1269 (-2.9A)
ZN  A1267 ( 3.3A)
ZN  A1267 ( 3.2A)
0.25A51.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OZR_C_HAEC3001_1
(COLLAGENASE 3)		3b8z PROTEIN ADAMTS-5
(Homo
sapiens)		4 / 4HIS A 410
GLU A 411
HIS A 414
HIS A 420
 ZN  A 901 ( 3.2A)
294  A 801 (-2.7A)
ZN  A 901 ( 3.3A)
ZN  A 901 ( 3.3A)
0.25A23.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OZR_C_HAEC3001_1
(COLLAGENASE 3)		3ba0 MACROPHAGE
METALLOELASTASE
(Homo
sapiens)		4 / 4HIS A 218
GLU A 219
HIS A 222
HIS A 228
 ZN  A 471 (-4.0A)
ZN  A 471 ( 3.2A)
HAE  A 477 ( 3.1A)
ZN  A 471 (-3.7A)
0.34A28.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OZR_C_HAEC3001_1
(COLLAGENASE 3)		3edi TOLLOID-LIKE PROTEIN
1
(Homo
sapiens)		4 / 4HIS A  92
GLU A  93
HIS A  96
HIS A 102
 ZN  A 210 (-3.2A)
ZN  A 210 ( 4.3A)
ZN  A 210 (-3.3A)
ZN  A 210 (-3.2A)
0.12A23.42
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2OZR_C_HAEC3001_1
(COLLAGENASE 3)		3o2x COLLAGENASE 3
(Homo
sapiens)		4 / 4HIS A1222
GLU A1223
HIS A1226
HIS A1232
 ZN  A1999 ( 3.2A)
3O2  A1801 (-2.7A)
ZN  A1999 ( 3.4A)
ZN  A1999 ( 3.2A)
0.09A98.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OZR_C_HAEC3001_1
(COLLAGENASE 3)		3q2h A DISINTEGRIN AND
METALLOPROTEINASE
WITH THROMBOSPONDIN
MOTIFS 1
(Homo
sapiens)		4 / 4HIS A 149
GLU A 150
HIS A 153
HIS A 159
 ZN  A 401 ( 3.3A)
QHF  A   1 (-2.6A)
QHF  A   1 ( 3.0A)
ZN  A 401 ( 3.2A)
0.25A20.77
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2OZR_C_HAEC3001_1
(COLLAGENASE 3)		3shi INTERSTITIAL
COLLAGENASE
(Homo
sapiens)		4 / 4HIS A 218
GLU A 219
HIS A 222
HIS A 228
 ZN  A 301 (-3.3A)
ZN  A 301 ( 4.7A)
ZN  A 301 (-3.4A)
ZN  A 301 (-3.3A)
0.33A58.28
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2OZR_C_HAEC3001_1
(COLLAGENASE 3)		3v96 STROMELYSIN-2
(Homo
sapiens)		4 / 4HIS B 217
GLU B 218
HIS B 221
HIS B 227
 ZN  B 301 (-3.2A)
ZN  B 301 ( 3.9A)
ZN  B 301 (-3.3A)
ZN  B 301 (-3.2A)
0.19A61.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OZR_C_HAEC3001_1
(COLLAGENASE 3)		4dd8 DISINTEGRIN AND
METALLOPROTEINASE
DOMAIN-CONTAINING
PROTEIN 8
(Homo
sapiens)		4 / 4HIS A 334
GLU A 335
HIS A 338
HIS A 344
 ZN  A1002 ( 3.3A)
BAT  A1000 (-2.7A)
ZN  A1002 (-3.3A)
ZN  A1002 ( 3.3A)
0.44A22.73
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2OZR_C_HAEC3001_1
(COLLAGENASE 3)		4gr8 MACROPHAGE
METALLOELASTASE
(Homo
sapiens)		4 / 4HIS A 218
GLU A 219
HIS A 222
HIS A 228
R4C  A 306 ( 3.2A)
R4C  A 306 (-2.7A)
ZN  A 301 ( 3.2A)
ZN  A 301 ( 3.2A)
0.32A58.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OZR_C_HAEC3001_1
(COLLAGENASE 3)		4gwn MEPRIN A SUBUNIT
BETA
(Homo
sapiens)		4 / 4HIS A 152
GLU A 153
HIS A 156
HIS A 162
 CD  A 701 (-3.7A)
CD  A 701 (-3.5A)
CD  A 701 (-3.7A)
CD  A 701 (-3.7A)
0.20A16.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OZR_C_HAEC3001_1
(COLLAGENASE 3)		4qgn 1,2-DIHYDROXY-3-KETO
-5-METHYLTHIOPENTENE
DIOXYGENASE
(Homo
sapiens)		4 / 4HIS A 133
GLU A  94
HIS A  90
HIS A  88
 FE  A 201 (-3.3A)
FE  A 201 ( 2.7A)
FE  A 201 (-3.3A)
FE  A 201 (-3.4A)
1.03A18.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OZR_C_HAEC3001_1
(COLLAGENASE 3)		4wk7 A DISINTEGRIN AND
METALLOPROTEINASE
WITH THROMBOSPONDIN
MOTIFS 4
(Homo
sapiens)		4 / 4HIS A 361
GLU A 362
HIS A 365
HIS A 371
 ZN  A 501 ( 3.2A)
3PQ  A 505 (-2.6A)
ZN  A 501 ( 3.3A)
ZN  A 501 ( 3.2A)
0.34A25.71
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2OZR_C_HAEC3001_1
(COLLAGENASE 3)		4xct MATRIX
METALLOPROTEINASE-9,
MATRIX
METALLOPROTEINASE-9
(Homo
sapiens)		4 / 4HIS A 226
GLU A 227
HIS A 230
HIS A 236
 ZN  A 302 ( 3.2A)
N73  A 301 (-2.5A)
ZN  A 302 ( 3.3A)
ZN  A 302 ( 3.3A)
0.18A60.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2OZR_C_HAEC3001_1
(COLLAGENASE 3)		5h0u MATRIX
METALLOPROTEINASE-14
(Homo
sapiens)		4 / 4HIS A 239
GLU A 240
HIS A 243
HIS A 249
 ZN  A 302 ( 3.3A)
GOL  A 311 (-4.2A)
ZN  A 302 (-3.4A)
ZN  A 302 (-3.2A)
0.18A47.22
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2OZR_C_HAEC3001_1
(COLLAGENASE 3)		5th6 MATRIX
METALLOPROTEINASE-9,
MATRIX
METALLOPROTEINASE-9
(Homo
sapiens)		4 / 4HIS A 401
GLU A 402
HIS A 405
HIS A 411
 ZN  A 501 (-3.3A)
ZN  A 501 ( 4.2A)
ZN  A 501 (-3.2A)
ZN  A 501 (-3.1A)
0.12A43.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OZR_C_HAEC3001_1
(COLLAGENASE 3)		6bdz DISINTEGRIN AND
METALLOPROTEINASE
DOMAIN-CONTAINING
PROTEIN 10
(Homo
sapiens)		4 / 4HIS A 383
GLU A 384
HIS A 387
HIS A 393
 ZN  A 705 (-3.3A)
ZN  A 705 (-3.8A)
ZN  A 705 (-4.0A)
ZN  A 705 (-3.2A)
0.34A18.67
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2OZR_D_HAED3002_1
(COLLAGENASE 3)		1hfs STROMELYSIN-1
(Homo
sapiens)		4 / 4HIS A 201
GLU A 202
HIS A 205
HIS A 211
 ZN  A 257 ( 3.1A)
L04  A 256 ( 2.7A)
ZN  A 257 ( 3.2A)
ZN  A 257 ( 3.1A)
0.34A60.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OZR_D_HAED3002_1
(COLLAGENASE 3)		1l6j MATRIX
METALLOPROTEINASE-9
(Homo
sapiens)		4 / 4HIS A 401
GLU A 402
HIS A 405
HIS A 411
 ZN  A 500 (-3.4A)
ZN  A 500 ( 4.3A)
ZN  A 500 (-3.2A)
ZN  A 500 (-3.4A)
0.19A24.36
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2OZR_D_HAED3002_1
(COLLAGENASE 3)		1qib 72 KDA TYPE IV
COLLAGENASE
(Homo
sapiens)		4 / 4HIS A 201
GLU A 202
HIS A 205
HIS A 211
 ZN  A 501 (-3.5A)
ZN  A 501 ( 4.5A)
ZN  A 501 (-3.5A)
ZN  A 501 (-3.5A)
0.30A65.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OZR_D_HAED3002_1
(COLLAGENASE 3)		1r55 ADAM 33
(Homo
sapiens)		4 / 4HIS A 345
GLU A 346
HIS A 349
HIS A 355
 ZN  A 201 ( 3.3A)
097  A 518 (-2.9A)
ZN  A 201 ( 3.2A)
ZN  A 201 ( 3.3A)
0.39A24.32
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2OZR_D_HAED3002_1
(COLLAGENASE 3)		1rm8 MATRIX
METALLOPROTEINASE-16
(Homo
sapiens)		4 / 4HIS A 246
GLU A 247
HIS A 250
HIS A 256
 ZN  A 500 ( 3.3A)
BAT  A 800 (-2.7A)
ZN  A 500 ( 3.2A)
ZN  A 500 ( 3.3A)
0.18A47.75
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2OZR_D_HAED3002_1
(COLLAGENASE 3)		1slm STROMELYSIN-1
(Homo
sapiens)		4 / 4HIS A 201
GLU A 202
HIS A 205
HIS A 211
 ZN  A 257 ( 3.0A)
ZN  A 257 ( 4.1A)
ZN  A 257 ( 3.2A)
ZN  A 257 ( 3.1A)
0.21A43.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OZR_D_HAED3002_1
(COLLAGENASE 3)		1xcr HYPOTHETICAL PROTEIN
PTD012
(Homo
sapiens)		4 / 4HIS A 268
GLU A 110
HIS A 278
HIS A 266
 ZN  A1001 ( 3.2A)
ACY  A2001 ( 3.7A)
ZN  A1001 ( 3.2A)
ZN  A1001 ( 3.2A)
0.98A19.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OZR_D_HAED3002_1
(COLLAGENASE 3)		2fv5 ADAM 17
(Homo
sapiens)		4 / 4HIS A 405
GLU A 406
HIS A 409
HIS A 415
 ZN  A   3 ( 3.2A)
541  A   1 (-2.6A)
ZN  A   3 ( 3.3A)
ZN  A   3 ( 3.2A)
0.31A22.64
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2OZR_D_HAED3002_1
(COLLAGENASE 3)		2jsd MATRIX
METALLOPROTEINASE-20
(Homo
sapiens)		4 / 4HIS A 226
GLU A 227
HIS A 230
HIS A 236
NGH  A 277 ( 3.0A)
NGH  A 277 (-3.6A)
ZN  A 276 ( 3.3A)
ZN  A 276 ( 3.0A)
0.61A57.14
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2OZR_D_HAED3002_1
(COLLAGENASE 3)		2oy4 NEUTROPHIL
COLLAGENASE
(Homo
sapiens)		4 / 4HIS A 197
GLU A 198
HIS A 201
HIS A 207
 ZN  A 999 (-3.2A)
ZN  A 999 ( 4.4A)
ZN  A 999 (-3.4A)
ZN  A 999 (-3.2A)
0.18A60.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OZR_D_HAED3002_1
(COLLAGENASE 3)		2rjq ADAMTS-5
(Homo
sapiens)		4 / 4HIS A 410
GLU A 411
HIS A 414
HIS A 420
 ZN  A   1 ( 3.2A)
BAT  A 559 (-2.5A)
ZN  A   1 ( 3.3A)
ZN  A   1 ( 3.3A)
0.23A19.14
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2OZR_D_HAED3002_1
(COLLAGENASE 3)		2y6c MATRILYSIN
(Homo
sapiens)		4 / 4HIS A 219
GLU A 220
HIS A 223
HIS A 229
 ZN  A1267 ( 3.2A)
TQI  A1269 (-2.9A)
ZN  A1267 ( 3.3A)
ZN  A1267 ( 3.2A)
0.30A51.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OZR_D_HAED3002_1
(COLLAGENASE 3)		3b8z PROTEIN ADAMTS-5
(Homo
sapiens)		4 / 4HIS A 410
GLU A 411
HIS A 414
HIS A 420
 ZN  A 901 ( 3.2A)
294  A 801 (-2.7A)
ZN  A 901 ( 3.3A)
ZN  A 901 ( 3.3A)
0.30A23.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OZR_D_HAED3002_1
(COLLAGENASE 3)		3ba0 MACROPHAGE
METALLOELASTASE
(Homo
sapiens)		4 / 4HIS A 218
GLU A 219
HIS A 222
HIS A 228
 ZN  A 471 (-4.0A)
ZN  A 471 ( 3.2A)
HAE  A 477 ( 3.1A)
ZN  A 471 (-3.7A)
0.31A28.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OZR_D_HAED3002_1
(COLLAGENASE 3)		3edi TOLLOID-LIKE PROTEIN
1
(Homo
sapiens)		4 / 4HIS A  92
GLU A  93
HIS A  96
HIS A 102
 ZN  A 210 (-3.2A)
ZN  A 210 ( 4.3A)
ZN  A 210 (-3.3A)
ZN  A 210 (-3.2A)
0.22A23.42
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2OZR_D_HAED3002_1
(COLLAGENASE 3)		3o2x COLLAGENASE 3
(Homo
sapiens)		4 / 4HIS A1222
GLU A1223
HIS A1226
HIS A1232
 ZN  A1999 ( 3.2A)
3O2  A1801 (-2.7A)
ZN  A1999 ( 3.4A)
ZN  A1999 ( 3.2A)
0.16A98.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OZR_D_HAED3002_1
(COLLAGENASE 3)		3q2h A DISINTEGRIN AND
METALLOPROTEINASE
WITH THROMBOSPONDIN
MOTIFS 1
(Homo
sapiens)		4 / 4HIS A 149
GLU A 150
HIS A 153
HIS A 159
 ZN  A 401 ( 3.3A)
QHF  A   1 (-2.6A)
QHF  A   1 ( 3.0A)
ZN  A 401 ( 3.2A)
0.21A20.77
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2OZR_D_HAED3002_1
(COLLAGENASE 3)		3shi INTERSTITIAL
COLLAGENASE
(Homo
sapiens)		4 / 4HIS A 218
GLU A 219
HIS A 222
HIS A 228
 ZN  A 301 (-3.3A)
ZN  A 301 ( 4.7A)
ZN  A 301 (-3.4A)
ZN  A 301 (-3.3A)
0.32A58.28
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2OZR_D_HAED3002_1
(COLLAGENASE 3)		3v96 STROMELYSIN-2
(Homo
sapiens)		4 / 4HIS B 217
GLU B 218
HIS B 221
HIS B 227
 ZN  B 301 (-3.2A)
ZN  B 301 ( 3.9A)
ZN  B 301 (-3.3A)
ZN  B 301 (-3.2A)
0.15A61.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OZR_D_HAED3002_1
(COLLAGENASE 3)		4dd8 DISINTEGRIN AND
METALLOPROTEINASE
DOMAIN-CONTAINING
PROTEIN 8
(Homo
sapiens)		4 / 4HIS A 334
GLU A 335
HIS A 338
HIS A 344
 ZN  A1002 ( 3.3A)
BAT  A1000 (-2.7A)
ZN  A1002 (-3.3A)
ZN  A1002 ( 3.3A)
0.40A22.73
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2OZR_D_HAED3002_1
(COLLAGENASE 3)		4gr8 MACROPHAGE
METALLOELASTASE
(Homo
sapiens)		4 / 4HIS A 218
GLU A 219
HIS A 222
HIS A 228
R4C  A 306 ( 3.2A)
R4C  A 306 (-2.7A)
ZN  A 301 ( 3.2A)
ZN  A 301 ( 3.2A)
0.40A58.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OZR_D_HAED3002_1
(COLLAGENASE 3)		4gwn MEPRIN A SUBUNIT
BETA
(Homo
sapiens)		4 / 4HIS A 152
GLU A 153
HIS A 156
HIS A 162
 CD  A 701 (-3.7A)
CD  A 701 (-3.5A)
CD  A 701 (-3.7A)
CD  A 701 (-3.7A)
0.22A16.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OZR_D_HAED3002_1
(COLLAGENASE 3)		4qgn 1,2-DIHYDROXY-3-KETO
-5-METHYLTHIOPENTENE
DIOXYGENASE
(Homo
sapiens)		4 / 4HIS A 133
GLU A  94
HIS A  90
HIS A  88
 FE  A 201 (-3.3A)
FE  A 201 ( 2.7A)
FE  A 201 (-3.3A)
FE  A 201 (-3.4A)
1.01A18.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OZR_D_HAED3002_1
(COLLAGENASE 3)		4wk7 A DISINTEGRIN AND
METALLOPROTEINASE
WITH THROMBOSPONDIN
MOTIFS 4
(Homo
sapiens)		4 / 4HIS A 361
GLU A 362
HIS A 365
HIS A 371
 ZN  A 501 ( 3.2A)
3PQ  A 505 (-2.6A)
ZN  A 501 ( 3.3A)
ZN  A 501 ( 3.2A)
0.37A25.71
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2OZR_D_HAED3002_1
(COLLAGENASE 3)		4xct MATRIX
METALLOPROTEINASE-9,
MATRIX
METALLOPROTEINASE-9
(Homo
sapiens)		4 / 4HIS A 226
GLU A 227
HIS A 230
HIS A 236
 ZN  A 302 ( 3.2A)
N73  A 301 (-2.5A)
ZN  A 302 ( 3.3A)
ZN  A 302 ( 3.3A)
0.24A60.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2OZR_D_HAED3002_1
(COLLAGENASE 3)		5h0u MATRIX
METALLOPROTEINASE-14
(Homo
sapiens)		4 / 4HIS A 239
GLU A 240
HIS A 243
HIS A 249
 ZN  A 302 ( 3.3A)
GOL  A 311 (-4.2A)
ZN  A 302 (-3.4A)
ZN  A 302 (-3.2A)
0.22A47.22
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2OZR_D_HAED3002_1
(COLLAGENASE 3)		5th6 MATRIX
METALLOPROTEINASE-9,
MATRIX
METALLOPROTEINASE-9
(Homo
sapiens)		4 / 4HIS A 401
GLU A 402
HIS A 405
HIS A 411
 ZN  A 501 (-3.3A)
ZN  A 501 ( 4.2A)
ZN  A 501 (-3.2A)
ZN  A 501 (-3.1A)
0.13A43.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OZR_D_HAED3002_1
(COLLAGENASE 3)		6bdz DISINTEGRIN AND
METALLOPROTEINASE
DOMAIN-CONTAINING
PROTEIN 10
(Homo
sapiens)		4 / 4HIS A 383
GLU A 384
HIS A 387
HIS A 393
 ZN  A 705 (-3.3A)
ZN  A 705 (-3.8A)
ZN  A 705 (-4.0A)
ZN  A 705 (-3.2A)
0.31A18.67
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2OZR_E_HAEE3003_1
(COLLAGENASE 3)		1hfs STROMELYSIN-1
(Homo
sapiens)		4 / 4HIS A 201
GLU A 202
HIS A 205
HIS A 211
 ZN  A 257 ( 3.1A)
L04  A 256 ( 2.7A)
ZN  A 257 ( 3.2A)
ZN  A 257 ( 3.1A)
0.37A60.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OZR_E_HAEE3003_1
(COLLAGENASE 3)		1kcw CERULOPLASMIN
(Homo
sapiens)		4 / 4HIS A 101
GLU A 112
HIS A 980
HIS A 978
 CU  A1052 (-3.2A)
None
CU  A1050 (-3.0A)
CU  A1052 ( 3.2A)
1.33A10.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OZR_E_HAEE3003_1
(COLLAGENASE 3)		1l6j MATRIX
METALLOPROTEINASE-9
(Homo
sapiens)		4 / 4HIS A 401
GLU A 402
HIS A 405
HIS A 411
 ZN  A 500 (-3.4A)
ZN  A 500 ( 4.3A)
ZN  A 500 (-3.2A)
ZN  A 500 (-3.4A)
0.27A24.36
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2OZR_E_HAEE3003_1
(COLLAGENASE 3)		1qib 72 KDA TYPE IV
COLLAGENASE
(Homo
sapiens)		4 / 4HIS A 201
GLU A 202
HIS A 205
HIS A 211
 ZN  A 501 (-3.5A)
ZN  A 501 ( 4.5A)
ZN  A 501 (-3.5A)
ZN  A 501 (-3.5A)
0.22A65.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OZR_E_HAEE3003_1
(COLLAGENASE 3)		1r55 ADAM 33
(Homo
sapiens)		4 / 4HIS A 345
GLU A 346
HIS A 349
HIS A 355
 ZN  A 201 ( 3.3A)
097  A 518 (-2.9A)
ZN  A 201 ( 3.2A)
ZN  A 201 ( 3.3A)
0.39A24.32
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2OZR_E_HAEE3003_1
(COLLAGENASE 3)		1rm8 MATRIX
METALLOPROTEINASE-16
(Homo
sapiens)		4 / 4HIS A 246
GLU A 247
HIS A 250
HIS A 256
 ZN  A 500 ( 3.3A)
BAT  A 800 (-2.7A)
ZN  A 500 ( 3.2A)
ZN  A 500 ( 3.3A)
0.22A47.75
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2OZR_E_HAEE3003_1
(COLLAGENASE 3)		1slm STROMELYSIN-1
(Homo
sapiens)		4 / 4HIS A 201
GLU A 202
HIS A 205
HIS A 211
 ZN  A 257 ( 3.0A)
ZN  A 257 ( 4.1A)
ZN  A 257 ( 3.2A)
ZN  A 257 ( 3.1A)
0.38A43.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OZR_E_HAEE3003_1
(COLLAGENASE 3)		1xcr HYPOTHETICAL PROTEIN
PTD012
(Homo
sapiens)		4 / 4HIS A 268
GLU A 110
HIS A 278
HIS A 266
 ZN  A1001 ( 3.2A)
ACY  A2001 ( 3.7A)
ZN  A1001 ( 3.2A)
ZN  A1001 ( 3.2A)
0.99A19.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OZR_E_HAEE3003_1
(COLLAGENASE 3)		2fv5 ADAM 17
(Homo
sapiens)		4 / 4HIS A 405
GLU A 406
HIS A 409
HIS A 415
 ZN  A   3 ( 3.2A)
541  A   1 (-2.6A)
ZN  A   3 ( 3.3A)
ZN  A   3 ( 3.2A)
0.31A22.64
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2OZR_E_HAEE3003_1
(COLLAGENASE 3)		2jsd MATRIX
METALLOPROTEINASE-20
(Homo
sapiens)		4 / 4HIS A 226
GLU A 227
HIS A 230
HIS A 236
NGH  A 277 ( 3.0A)
NGH  A 277 (-3.6A)
ZN  A 276 ( 3.3A)
ZN  A 276 ( 3.0A)
0.69A57.14
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2OZR_E_HAEE3003_1
(COLLAGENASE 3)		2oy4 NEUTROPHIL
COLLAGENASE
(Homo
sapiens)		4 / 4HIS A 197
GLU A 198
HIS A 201
HIS A 207
 ZN  A 999 (-3.2A)
ZN  A 999 ( 4.4A)
ZN  A 999 (-3.4A)
ZN  A 999 (-3.2A)
0.24A60.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OZR_E_HAEE3003_1
(COLLAGENASE 3)		2rjq ADAMTS-5
(Homo
sapiens)		4 / 4HIS A 410
GLU A 411
HIS A 414
HIS A 420
 ZN  A   1 ( 3.2A)
BAT  A 559 (-2.5A)
ZN  A   1 ( 3.3A)
ZN  A   1 ( 3.3A)
0.25A19.14
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2OZR_E_HAEE3003_1
(COLLAGENASE 3)		2y6c MATRILYSIN
(Homo
sapiens)		4 / 4HIS A 219
GLU A 220
HIS A 223
HIS A 229
 ZN  A1267 ( 3.2A)
TQI  A1269 (-2.9A)
ZN  A1267 ( 3.3A)
ZN  A1267 ( 3.2A)
0.30A51.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OZR_E_HAEE3003_1
(COLLAGENASE 3)		3b8z PROTEIN ADAMTS-5
(Homo
sapiens)		4 / 4HIS A 410
GLU A 411
HIS A 414
HIS A 420
 ZN  A 901 ( 3.2A)
294  A 801 (-2.7A)
ZN  A 901 ( 3.3A)
ZN  A 901 ( 3.3A)
0.37A23.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OZR_E_HAEE3003_1
(COLLAGENASE 3)		3ba0 MACROPHAGE
METALLOELASTASE
(Homo
sapiens)		4 / 4HIS A 218
GLU A 219
HIS A 222
HIS A 228
 ZN  A 471 (-4.0A)
ZN  A 471 ( 3.2A)
HAE  A 477 ( 3.1A)
ZN  A 471 (-3.7A)
0.42A28.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OZR_E_HAEE3003_1
(COLLAGENASE 3)		3edi TOLLOID-LIKE PROTEIN
1
(Homo
sapiens)		4 / 4HIS A  92
GLU A  93
HIS A  96
HIS A 102
 ZN  A 210 (-3.2A)
ZN  A 210 ( 4.3A)
ZN  A 210 (-3.3A)
ZN  A 210 (-3.2A)
0.33A23.42
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2OZR_E_HAEE3003_1
(COLLAGENASE 3)		3o2x COLLAGENASE 3
(Homo
sapiens)		4 / 4HIS A1222
GLU A1223
HIS A1226
HIS A1232
 ZN  A1999 ( 3.2A)
3O2  A1801 (-2.7A)
ZN  A1999 ( 3.4A)
ZN  A1999 ( 3.2A)
0.31A98.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OZR_E_HAEE3003_1
(COLLAGENASE 3)		3q2h A DISINTEGRIN AND
METALLOPROTEINASE
WITH THROMBOSPONDIN
MOTIFS 1
(Homo
sapiens)		4 / 4HIS A 149
GLU A 150
HIS A 153
HIS A 159
 ZN  A 401 ( 3.3A)
QHF  A   1 (-2.6A)
QHF  A   1 ( 3.0A)
ZN  A 401 ( 3.2A)
0.27A20.77
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2OZR_E_HAEE3003_1
(COLLAGENASE 3)		3shi INTERSTITIAL
COLLAGENASE
(Homo
sapiens)		4 / 4HIS A 218
GLU A 219
HIS A 222
HIS A 228
 ZN  A 301 (-3.3A)
ZN  A 301 ( 4.7A)
ZN  A 301 (-3.4A)
ZN  A 301 (-3.3A)
0.31A58.28
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2OZR_E_HAEE3003_1
(COLLAGENASE 3)		3v96 STROMELYSIN-2
(Homo
sapiens)		4 / 4HIS B 217
GLU B 218
HIS B 221
HIS B 227
 ZN  B 301 (-3.2A)
ZN  B 301 ( 3.9A)
ZN  B 301 (-3.3A)
ZN  B 301 (-3.2A)
0.32A61.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OZR_E_HAEE3003_1
(COLLAGENASE 3)		4dd8 DISINTEGRIN AND
METALLOPROTEINASE
DOMAIN-CONTAINING
PROTEIN 8
(Homo
sapiens)		4 / 4HIS A 334
GLU A 335
HIS A 338
HIS A 344
 ZN  A1002 ( 3.3A)
BAT  A1000 (-2.7A)
ZN  A1002 (-3.3A)
ZN  A1002 ( 3.3A)
0.42A22.73
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2OZR_E_HAEE3003_1
(COLLAGENASE 3)		4gr8 MACROPHAGE
METALLOELASTASE
(Homo
sapiens)		4 / 4HIS A 218
GLU A 219
HIS A 222
HIS A 228
R4C  A 306 ( 3.2A)
R4C  A 306 (-2.7A)
ZN  A 301 ( 3.2A)
ZN  A 301 ( 3.2A)
0.38A58.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OZR_E_HAEE3003_1
(COLLAGENASE 3)		4gwn MEPRIN A SUBUNIT
BETA
(Homo
sapiens)		4 / 4HIS A 152
GLU A 153
HIS A 156
HIS A 162
 CD  A 701 (-3.7A)
CD  A 701 (-3.5A)
CD  A 701 (-3.7A)
CD  A 701 (-3.7A)
0.38A16.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OZR_E_HAEE3003_1
(COLLAGENASE 3)		4wk7 A DISINTEGRIN AND
METALLOPROTEINASE
WITH THROMBOSPONDIN
MOTIFS 4
(Homo
sapiens)		4 / 4HIS A 361
GLU A 362
HIS A 365
HIS A 371
 ZN  A 501 ( 3.2A)
3PQ  A 505 (-2.6A)
ZN  A 501 ( 3.3A)
ZN  A 501 ( 3.2A)
0.32A25.71
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2OZR_E_HAEE3003_1
(COLLAGENASE 3)		4xct MATRIX
METALLOPROTEINASE-9,
MATRIX
METALLOPROTEINASE-9
(Homo
sapiens)		4 / 4HIS A 226
GLU A 227
HIS A 230
HIS A 236
 ZN  A 302 ( 3.2A)
N73  A 301 (-2.5A)
ZN  A 302 ( 3.3A)
ZN  A 302 ( 3.3A)
0.29A60.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2OZR_E_HAEE3003_1
(COLLAGENASE 3)		5h0u MATRIX
METALLOPROTEINASE-14
(Homo
sapiens)		4 / 4HIS A 239
GLU A 240
HIS A 243
HIS A 249
 ZN  A 302 ( 3.3A)
GOL  A 311 (-4.2A)
ZN  A 302 (-3.4A)
ZN  A 302 (-3.2A)
0.23A47.22
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2OZR_E_HAEE3003_1
(COLLAGENASE 3)		5th6 MATRIX
METALLOPROTEINASE-9,
MATRIX
METALLOPROTEINASE-9
(Homo
sapiens)		4 / 4HIS A 401
GLU A 402
HIS A 405
HIS A 411
 ZN  A 501 (-3.3A)
ZN  A 501 ( 4.2A)
ZN  A 501 (-3.2A)
ZN  A 501 (-3.1A)
0.26A43.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OZR_E_HAEE3003_1
(COLLAGENASE 3)		6bdz DISINTEGRIN AND
METALLOPROTEINASE
DOMAIN-CONTAINING
PROTEIN 10
(Homo
sapiens)		4 / 4HIS A 383
GLU A 384
HIS A 387
HIS A 393
 ZN  A 705 (-3.3A)
ZN  A 705 (-3.8A)
ZN  A 705 (-4.0A)
ZN  A 705 (-3.2A)
0.48A18.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OZR_F_HAEF3004_1
(COLLAGENASE 3)		1ck7 PROTEIN (GELATINASE
A)
(Homo
sapiens)		3 / 3HIS A 403
HIS A 407
HIS A 413
 ZN  A 990 ( 3.4A)
ZN  A 990 ( 3.3A)
ZN  A 990 ( 3.4A)
0.24A22.66
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2OZR_F_HAEF3004_1
(COLLAGENASE 3)		1eak 72 KDA TYPE IV
COLLAGENASE
(Homo
sapiens)		3 / 3HIS A 403
HIS A 407
HIS A 413
 ZN  A 997 (-3.5A)
ZN  A 997 (-3.6A)
ZN  A 997 (-3.5A)
0.35A30.42
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2OZR_F_HAEF3004_1
(COLLAGENASE 3)		1hfs STROMELYSIN-1
(Homo
sapiens)		3 / 3HIS A 201
HIS A 205
HIS A 211
 ZN  A 257 ( 3.1A)
ZN  A 257 ( 3.2A)
ZN  A 257 ( 3.1A)
0.32A60.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OZR_F_HAEF3004_1
(COLLAGENASE 3)		1l6j MATRIX
METALLOPROTEINASE-9
(Homo
sapiens)		3 / 3HIS A 401
HIS A 405
HIS A 411
 ZN  A 500 (-3.4A)
ZN  A 500 (-3.2A)
ZN  A 500 (-3.4A)
0.19A24.36
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2OZR_F_HAEF3004_1
(COLLAGENASE 3)		1qib 72 KDA TYPE IV
COLLAGENASE
(Homo
sapiens)		3 / 3HIS A 201
HIS A 205
HIS A 211
 ZN  A 501 (-3.5A)
ZN  A 501 (-3.5A)
ZN  A 501 (-3.5A)
0.19A65.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OZR_F_HAEF3004_1
(COLLAGENASE 3)		1r55 ADAM 33
(Homo
sapiens)		3 / 3HIS A 345
HIS A 349
HIS A 355
 ZN  A 201 ( 3.3A)
ZN  A 201 ( 3.2A)
ZN  A 201 ( 3.3A)
0.28A24.32
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2OZR_F_HAEF3004_1
(COLLAGENASE 3)		1rm8 MATRIX
METALLOPROTEINASE-16
(Homo
sapiens)		3 / 3HIS A 246
HIS A 250
HIS A 256
 ZN  A 500 ( 3.3A)
ZN  A 500 ( 3.2A)
ZN  A 500 ( 3.3A)
0.25A47.75
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2OZR_F_HAEF3004_1
(COLLAGENASE 3)		1slm STROMELYSIN-1
(Homo
sapiens)		3 / 3HIS A 201
HIS A 205
HIS A 211
 ZN  A 257 ( 3.0A)
ZN  A 257 ( 3.2A)
ZN  A 257 ( 3.1A)
0.31A43.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OZR_F_HAEF3004_1
(COLLAGENASE 3)		1su3 INTERSTITIAL
COLLAGENASE
(Homo
sapiens)		3 / 3HIS A 218
HIS A 222
HIS A 228
 ZN  A 913 (-3.2A)
ZN  A 913 (-3.2A)
ZN  A 913 (-3.2A)
0.24A27.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OZR_F_HAEF3004_1
(COLLAGENASE 3)		2fv5 ADAM 17
(Homo
sapiens)		3 / 3HIS A 405
HIS A 409
HIS A 415
 ZN  A   3 ( 3.2A)
ZN  A   3 ( 3.3A)
ZN  A   3 ( 3.2A)
0.23A22.64
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2OZR_F_HAEF3004_1
(COLLAGENASE 3)		2jsd MATRIX
METALLOPROTEINASE-20
(Homo
sapiens)		3 / 3HIS A 226
HIS A 230
HIS A 236
NGH  A 277 ( 3.0A)
ZN  A 276 ( 3.3A)
ZN  A 276 ( 3.0A)
0.40A57.14
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2OZR_F_HAEF3004_1
(COLLAGENASE 3)		2oy4 NEUTROPHIL
COLLAGENASE
(Homo
sapiens)		3 / 3HIS A 197
HIS A 201
HIS A 207
 ZN  A 999 (-3.2A)
ZN  A 999 (-3.4A)
ZN  A 999 (-3.2A)
0.17A60.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OZR_F_HAEF3004_1
(COLLAGENASE 3)		2rjq ADAMTS-5
(Homo
sapiens)		3 / 3HIS A 410
HIS A 414
HIS A 420
 ZN  A   1 ( 3.2A)
ZN  A   1 ( 3.3A)
ZN  A   1 ( 3.3A)
0.23A19.14
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2OZR_F_HAEF3004_1
(COLLAGENASE 3)		2y6c MATRILYSIN
(Homo
sapiens)		3 / 3HIS A 219
HIS A 223
HIS A 229
 ZN  A1267 ( 3.2A)
ZN  A1267 ( 3.3A)
ZN  A1267 ( 3.2A)
0.26A51.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OZR_F_HAEF3004_1
(COLLAGENASE 3)		2znv AMSH-LIKE PROTEASE
(Homo
sapiens)		3 / 3HIS A 410
HIS A 408
HIS A 362
 ZN  A   1 (-3.2A)
ZN  A   1 (-3.2A)
ZN  A   1 ( 3.3A)
0.40A20.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OZR_F_HAEF3004_1
(COLLAGENASE 3)		3b2z ADAMTS-4
(Homo
sapiens)		3 / 3HIS A 361
HIS A 365
HIS A 371
 ZN  A   1 (-3.0A)
ZN  A   1 (-3.3A)
ZN  A   1 (-3.2A)
0.24A20.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OZR_F_HAEF3004_1
(COLLAGENASE 3)		3b8z PROTEIN ADAMTS-5
(Homo
sapiens)		3 / 3HIS A 410
HIS A 414
HIS A 420
 ZN  A 901 ( 3.2A)
ZN  A 901 ( 3.3A)
ZN  A 901 ( 3.3A)
0.32A23.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OZR_F_HAEF3004_1
(COLLAGENASE 3)		3ba0 MACROPHAGE
METALLOELASTASE
(Homo
sapiens)		3 / 3HIS A 218
HIS A 222
HIS A 228
 ZN  A 471 (-4.0A)
HAE  A 477 ( 3.1A)
ZN  A 471 (-3.7A)
0.35A28.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OZR_F_HAEF3004_1
(COLLAGENASE 3)		3edi TOLLOID-LIKE PROTEIN
1
(Homo
sapiens)		3 / 3HIS A  92
HIS A  96
HIS A 102
 ZN  A 210 (-3.2A)
ZN  A 210 (-3.3A)
ZN  A 210 (-3.2A)
0.30A23.42
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2OZR_F_HAEF3004_1
(COLLAGENASE 3)		3o2x COLLAGENASE 3
(Homo
sapiens)		3 / 3HIS A1222
HIS A1226
HIS A1232
 ZN  A1999 ( 3.2A)
ZN  A1999 ( 3.4A)
ZN  A1999 ( 3.2A)
0.31A98.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OZR_F_HAEF3004_1
(COLLAGENASE 3)		3q2h A DISINTEGRIN AND
METALLOPROTEINASE
WITH THROMBOSPONDIN
MOTIFS 1
(Homo
sapiens)		3 / 3HIS A 149
HIS A 153
HIS A 159
 ZN  A 401 ( 3.3A)
QHF  A   1 ( 3.0A)
ZN  A 401 ( 3.2A)
0.24A20.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OZR_F_HAEF3004_1
(COLLAGENASE 3)		3rzu STAM-BINDING PROTEIN
(Homo
sapiens)		3 / 3HIS A 398
HIS A 396
HIS A 350
 ZN  A   2 (-3.4A)
ZN  A   2 (-3.5A)
ZN  A   2 (-3.5A)
0.54A20.71
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2OZR_F_HAEF3004_1
(COLLAGENASE 3)		3shi INTERSTITIAL
COLLAGENASE
(Homo
sapiens)		3 / 3HIS A 218
HIS A 222
HIS A 228
 ZN  A 301 (-3.3A)
ZN  A 301 (-3.4A)
ZN  A 301 (-3.3A)
0.22A58.28
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2OZR_F_HAEF3004_1
(COLLAGENASE 3)		3v96 STROMELYSIN-2
(Homo
sapiens)		3 / 3HIS B 217
HIS B 221
HIS B 227
 ZN  B 301 (-3.2A)
ZN  B 301 (-3.3A)
ZN  B 301 (-3.2A)
0.30A61.90
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2OZR_F_HAEF3004_1
(COLLAGENASE 3)		4auo INTERSTITIAL
COLLAGENASE
(Homo
sapiens)		3 / 3HIS A 199
HIS A 203
HIS A 209
 ZN  A1202 (-3.0A)
ZN  A1202 (-3.1A)
ZN  A1202 (-3.4A)
0.26A31.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OZR_F_HAEF3004_1
(COLLAGENASE 3)		4dd8 DISINTEGRIN AND
METALLOPROTEINASE
DOMAIN-CONTAINING
PROTEIN 8
(Homo
sapiens)		3 / 3HIS A 334
HIS A 338
HIS A 344
 ZN  A1002 ( 3.3A)
ZN  A1002 (-3.3A)
ZN  A1002 ( 3.3A)
0.18A22.73
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2OZR_F_HAEF3004_1
(COLLAGENASE 3)		4fvl COLLAGENASE 3
(Homo
sapiens)		3 / 3HIS A 222
HIS A 226
HIS A 232
 ZN  A 501 (-3.3A)
ZN  A 501 (-3.1A)
ZN  A 501 (-3.2A)
0.28A99.40
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2OZR_F_HAEF3004_1
(COLLAGENASE 3)		4gr8 MACROPHAGE
METALLOELASTASE
(Homo
sapiens)		3 / 3HIS A 218
HIS A 222
HIS A 228
R4C  A 306 ( 3.2A)
ZN  A 301 ( 3.2A)
ZN  A 301 ( 3.2A)
0.26A58.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OZR_F_HAEF3004_1
(COLLAGENASE 3)		4gwn MEPRIN A SUBUNIT
BETA
(Homo
sapiens)		3 / 3HIS A 152
HIS A 156
HIS A 162
 CD  A 701 (-3.7A)
CD  A 701 (-3.7A)
CD  A 701 (-3.7A)
0.34A16.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OZR_F_HAEF3004_1
(COLLAGENASE 3)		4igm 2-AMINO-3-CARBOXYMUC
ONATE-6-SEMIALDEHYDE
DECARBOXYLASE
(Homo
sapiens)		3 / 3HIS A   6
HIS A   8
HIS A 174
 ZN  A 401 (-3.4A)
ZN  A 401 (-3.5A)
ZN  A 401 (-3.3A)
0.42A17.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OZR_F_HAEF3004_1
(COLLAGENASE 3)		4wk7 A DISINTEGRIN AND
METALLOPROTEINASE
WITH THROMBOSPONDIN
MOTIFS 4
(Homo
sapiens)		3 / 3HIS A 361
HIS A 365
HIS A 371
 ZN  A 501 ( 3.2A)
ZN  A 501 ( 3.3A)
ZN  A 501 ( 3.2A)
0.27A25.71
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2OZR_F_HAEF3004_1
(COLLAGENASE 3)		4xct MATRIX
METALLOPROTEINASE-9,
MATRIX
METALLOPROTEINASE-9
(Homo
sapiens)		3 / 3HIS A 226
HIS A 230
HIS A 236
 ZN  A 302 ( 3.2A)
ZN  A 302 ( 3.3A)
ZN  A 302 ( 3.3A)
0.28A60.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2OZR_F_HAEF3004_1
(COLLAGENASE 3)		5h0u MATRIX
METALLOPROTEINASE-14
(Homo
sapiens)		3 / 3HIS A 239
HIS A 243
HIS A 249
 ZN  A 302 ( 3.3A)
ZN  A 302 (-3.4A)
ZN  A 302 (-3.2A)
0.19A47.22
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2OZR_F_HAEF3004_1
(COLLAGENASE 3)		5th6 MATRIX
METALLOPROTEINASE-9,
MATRIX
METALLOPROTEINASE-9
(Homo
sapiens)		3 / 3HIS A 401
HIS A 405
HIS A 411
 ZN  A 501 (-3.3A)
ZN  A 501 (-3.2A)
ZN  A 501 (-3.1A)
0.22A43.16
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2OZR_F_HAEF3004_1
(COLLAGENASE 3)		5ue2 MATRILYSIN
(Homo
sapiens)		3 / 3HIS A 194
HIS A 198
HIS A 204
 ZN  A 304 (-3.3A)
ZN  A 304 (-3.3A)
ZN  A 304 (-3.2A)
0.37A37.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OZR_F_HAEF3004_1
(COLLAGENASE 3)		6bdz DISINTEGRIN AND
METALLOPROTEINASE
DOMAIN-CONTAINING
PROTEIN 10
(Homo
sapiens)		3 / 3HIS A 383
HIS A 387
HIS A 393
 ZN  A 705 (-3.3A)
ZN  A 705 (-4.0A)
ZN  A 705 (-3.2A)
0.45A18.67
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3BA0_A_HAEA477_1
(MACROPHAGE
METALLOELASTASE)		1hfs STROMELYSIN-1
(Homo
sapiens)		3 / 3HIS A 166
GLU A 202
HIS A 205
 ZN  A 258 ( 3.0A)
L04  A 256 ( 2.7A)
ZN  A 257 ( 3.2A)
0.41A59.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BA0_A_HAEA477_1
(MACROPHAGE
METALLOELASTASE)		1l6j MATRIX
METALLOPROTEINASE-9
(Homo
sapiens)		3 / 3HIS A 190
GLU A 402
HIS A 405
 ZN  A 501 (-3.4A)
ZN  A 500 ( 4.3A)
ZN  A 500 (-3.2A)
0.52A26.82
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3BA0_A_HAEA477_1
(MACROPHAGE
METALLOELASTASE)		1qib 72 KDA TYPE IV
COLLAGENASE
(Homo
sapiens)		3 / 3HIS A 166
GLU A 202
HIS A 205
 ZN  A 502 (-3.5A)
ZN  A 501 ( 4.5A)
ZN  A 501 (-3.5A)
0.55A38.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BA0_A_HAEA477_1
(MACROPHAGE
METALLOELASTASE)		1rm8 MATRIX
METALLOPROTEINASE-16
(Homo
sapiens)		3 / 3HIS A 208
GLU A 247
HIS A 250
 ZN  A 501 (-3.2A)
BAT  A 800 (-2.7A)
ZN  A 500 ( 3.2A)
0.55A26.81
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3BA0_A_HAEA477_1
(MACROPHAGE
METALLOELASTASE)		1slm STROMELYSIN-1
(Homo
sapiens)		3 / 3HIS A 166
GLU A 202
HIS A 205
 ZN  A 258 ( 3.0A)
ZN  A 257 ( 4.1A)
ZN  A 257 ( 3.2A)
0.39A30.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BA0_A_HAEA477_1
(MACROPHAGE
METALLOELASTASE)		1xfd DIPEPTIDYL
AMINOPEPTIDASE-LIKE
PROTEIN 6
(Homo
sapiens)		3 / 3HIS A 213
GLU A 294
HIS A 301
None
0.87A18.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BA0_A_HAEA477_1
(MACROPHAGE
METALLOELASTASE)		2dq7 PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE FYN
(Homo
sapiens)		3 / 3HIS X 241
GLU X 237
HIS X 236
None
0.85A20.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BA0_A_HAEA477_1
(MACROPHAGE
METALLOELASTASE)		2efl FORMIN-BINDING
PROTEIN 1
(Homo
sapiens)		3 / 3HIS A 206
GLU A 203
HIS A 199
None
0.89A19.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BA0_A_HAEA477_1
(MACROPHAGE
METALLOELASTASE)		2ick ISOPENTENYL-DIPHOSPH
ATE DELTA ISOMERASE
(Homo
sapiens)		3 / 3HIS A 148
GLU A 147
HIS A  41
None
MN  A 229 ( 2.0A)
MN  A 229 (-3.4A)
0.67A19.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BA0_A_HAEA477_1
(MACROPHAGE
METALLOELASTASE)		2j1d DISHEVELED-ASSOCIATE
D ACTIVATOR OF
MORPHOGENESIS 1
(Homo
sapiens)		3 / 3HIS G 749
GLU G 750
HIS G 747
None
0.72A22.08
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3BA0_A_HAEA477_1
(MACROPHAGE
METALLOELASTASE)		2oy4 NEUTROPHIL
COLLAGENASE
(Homo
sapiens)		3 / 3HIS A 162
GLU A 198
HIS A 201
 ZN  A 998 (-3.3A)
ZN  A 999 ( 4.4A)
ZN  A 999 (-3.4A)
0.52A53.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BA0_A_HAEA477_1
(MACROPHAGE
METALLOELASTASE)		2pny ISOPENTENYL-DIPHOSPH
ATE DELTA-ISOMERASE
2
(Homo
sapiens)		3 / 3HIS A 147
GLU A 146
HIS A  40
None
MN  A 229 (-1.9A)
MN  A 229 (-3.3A)
0.68A19.27
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3BA0_A_HAEA477_1
(MACROPHAGE
METALLOELASTASE)		2y6c MATRILYSIN
(Homo
sapiens)		3 / 3HIS A 183
GLU A 220
HIS A 223
 ZN  A1266 ( 3.3A)
TQI  A1269 (-2.9A)
ZN  A1267 ( 3.3A)
0.43A54.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BA0_A_HAEA477_1
(MACROPHAGE
METALLOELASTASE)		3c10 HISTONE DEACETYLASE
7A
(Homo
sapiens)		3 / 3HIS A 806
GLU A 804
HIS A 814
None
0.66A19.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BA0_A_HAEA477_1
(MACROPHAGE
METALLOELASTASE)		3lgg ADENOSINE DEAMINASE
CECR1
(Homo
sapiens)		3 / 3HIS A  59
GLU A 168
HIS A 166
None
0.83A20.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BA0_A_HAEA477_1
(MACROPHAGE
METALLOELASTASE)		3lgg ADENOSINE DEAMINASE
CECR1
(Homo
sapiens)		3 / 3HIS A 301
GLU A 182
HIS A 267
None
CFE  A 513 (-3.0A)
CFE  A 513 (-3.9A)
0.81A20.04
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3BA0_A_HAEA477_1
(MACROPHAGE
METALLOELASTASE)		3o2x COLLAGENASE 3
(Homo
sapiens)		3 / 3HIS A1187
GLU A1223
HIS A1226
 ZN  A1998 ( 3.2A)
3O2  A1801 (-2.7A)
ZN  A1999 ( 3.4A)
0.56A56.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BA0_A_HAEA477_1
(MACROPHAGE
METALLOELASTASE)		3pja TRANSLIN
(Homo
sapiens)		3 / 3HIS A  90
GLU A  89
HIS A  88
None
0.86A19.24
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3BA0_A_HAEA477_1
(MACROPHAGE
METALLOELASTASE)		3shi INTERSTITIAL
COLLAGENASE
(Homo
sapiens)		3 / 3HIS A 183
GLU A 219
HIS A 222
 ZN  A 302 (-3.1A)
ZN  A 301 ( 4.7A)
ZN  A 301 (-3.4A)
0.53A58.02
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3BA0_A_HAEA477_1
(MACROPHAGE
METALLOELASTASE)		3v96 STROMELYSIN-2
(Homo
sapiens)		3 / 3HIS B 182
GLU B 218
HIS B 221
 ZN  B 302 (-3.2A)
ZN  B 301 ( 3.9A)
ZN  B 301 (-3.3A)
0.38A57.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BA0_A_HAEA477_1
(MACROPHAGE
METALLOELASTASE)		4ad9 BETA-LACTAMASE-LIKE
PROTEIN 2
(Homo
sapiens)		3 / 3HIS A 259
GLU A 255
HIS A 254
None
0.89A21.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BA0_A_HAEA477_1
(MACROPHAGE
METALLOELASTASE)		4bc6 SERINE/THREONINE-PRO
TEIN KINASE 10
(Homo
sapiens)		3 / 3HIS A 238
GLU A 239
HIS A 237
None
0.80A23.30
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3BA0_A_HAEA477_1
(MACROPHAGE
METALLOELASTASE)		4gr8 MACROPHAGE
METALLOELASTASE
(Homo
sapiens)		3 / 3HIS A 183
GLU A 219
HIS A 222
 ZN  A 302 (-3.2A)
R4C  A 306 (-2.7A)
ZN  A 301 ( 3.2A)
0.55A100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BA0_A_HAEA477_1
(MACROPHAGE
METALLOELASTASE)		4wxx DNA
(CYTOSINE-5)-METHYLT
RANSFERASE 1
(Homo
sapiens)		3 / 3HIS A1460
GLU A1480
HIS A1459
None
0.76A13.54
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3BA0_A_HAEA477_1
(MACROPHAGE
METALLOELASTASE)		4xct MATRIX
METALLOPROTEINASE-9,
MATRIX
METALLOPROTEINASE-9
(Homo
sapiens)		3 / 3HIS A 190
GLU A 227
HIS A 230
 ZN  A 303 ( 3.2A)
N73  A 301 (-2.5A)
ZN  A 302 ( 3.3A)
0.48A50.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BA0_A_HAEA477_1
(MACROPHAGE
METALLOELASTASE)		5do7 ATP-BINDING CASSETTE
SUB-FAMILY G MEMBER
8
(Homo
sapiens)		3 / 3HIS B 504
GLU B 503
HIS B 420
None
0.76A19.94
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3BA0_A_HAEA477_1
(MACROPHAGE
METALLOELASTASE)		5h0u MATRIX
METALLOPROTEINASE-14
(Homo
sapiens)		3 / 3HIS A 201
GLU A 240
HIS A 243
 ZN  A 303 (-3.2A)
GOL  A 311 (-4.2A)
ZN  A 302 (-3.4A)
0.39A31.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BA0_A_HAEA477_1
(MACROPHAGE
METALLOELASTASE)		5th6 MATRIX
METALLOPROTEINASE-9,
MATRIX
METALLOPROTEINASE-9
(Homo
sapiens)		3 / 3HIS A 190
GLU A 402
HIS A 405
 ZN  A 502 (-3.2A)
ZN  A 501 ( 4.2A)
ZN  A 501 (-3.2A)
0.49A22.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BA0_A_HAEA477_1
(MACROPHAGE
METALLOELASTASE)		5uj8 ORIGIN RECOGNITION
COMPLEX SUBUNIT 3
(Homo
sapiens)		3 / 3HIS A 586
GLU A 590
HIS A 591
None
0.80A19.55
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3KEC_A_HAEA272_1
(COLLAGENASE 3)		1hfs STROMELYSIN-1
(Homo
sapiens)		4 / 5HIS A 201
GLU A 202
HIS A 205
HIS A 211
 ZN  A 257 ( 3.1A)
L04  A 256 ( 2.7A)
ZN  A 257 ( 3.2A)
ZN  A 257 ( 3.1A)
0.27A61.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KEC_A_HAEA272_1
(COLLAGENASE 3)		1kcw CERULOPLASMIN
(Homo
sapiens)		4 / 5LEU A1018
HIS A 103
HIS A 161
HIS A1022
None
CU  A1051 (-3.3A)
CU  A1051 (-3.3A)
CU  A1051 (-3.2A)
1.00A10.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KEC_A_HAEA272_1
(COLLAGENASE 3)		1l6j MATRIX
METALLOPROTEINASE-9
(Homo
sapiens)		4 / 5HIS A 401
GLU A 402
HIS A 405
HIS A 411
 ZN  A 500 (-3.4A)
ZN  A 500 ( 4.3A)
ZN  A 500 (-3.2A)
ZN  A 500 (-3.4A)
0.15A24.12
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3KEC_A_HAEA272_1
(COLLAGENASE 3)		1qib 72 KDA TYPE IV
COLLAGENASE
(Homo
sapiens)		5 / 5LEU A 163
HIS A 201
GLU A 202
HIS A 205
HIS A 211
None
ZN  A 501 (-3.5A)
ZN  A 501 ( 4.5A)
ZN  A 501 (-3.5A)
ZN  A 501 (-3.5A)
0.64A65.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KEC_A_HAEA272_1
(COLLAGENASE 3)		1r55 ADAM 33
(Homo
sapiens)		4 / 5HIS A 345
GLU A 346
HIS A 349
HIS A 355
 ZN  A 201 ( 3.3A)
097  A 518 (-2.9A)
ZN  A 201 ( 3.2A)
ZN  A 201 ( 3.3A)
0.35A25.12
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3KEC_A_HAEA272_1
(COLLAGENASE 3)		1rm8 MATRIX
METALLOPROTEINASE-16
(Homo
sapiens)		4 / 5HIS A 246
GLU A 247
HIS A 250
HIS A 256
 ZN  A 500 ( 3.3A)
BAT  A 800 (-2.7A)
ZN  A 500 ( 3.2A)
ZN  A 500 ( 3.3A)
0.17A48.57
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3KEC_A_HAEA272_1
(COLLAGENASE 3)		1slm STROMELYSIN-1
(Homo
sapiens)		4 / 5HIS A 201
GLU A 202
HIS A 205
HIS A 211
 ZN  A 257 ( 3.0A)
ZN  A 257 ( 4.1A)
ZN  A 257 ( 3.2A)
ZN  A 257 ( 3.1A)
0.23A43.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KEC_A_HAEA272_1
(COLLAGENASE 3)		1xcr HYPOTHETICAL PROTEIN
PTD012
(Homo
sapiens)		4 / 5HIS A 268
GLU A 110
HIS A 278
HIS A 266
 ZN  A1001 ( 3.2A)
ACY  A2001 ( 3.7A)
ZN  A1001 ( 3.2A)
ZN  A1001 ( 3.2A)
0.98A18.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KEC_A_HAEA272_1
(COLLAGENASE 3)		2fv5 ADAM 17
(Homo
sapiens)		4 / 5HIS A 405
GLU A 406
HIS A 409
HIS A 415
 ZN  A   3 ( 3.2A)
541  A   1 (-2.6A)
ZN  A   3 ( 3.3A)
ZN  A   3 ( 3.2A)
0.29A22.64
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3KEC_A_HAEA272_1
(COLLAGENASE 3)		2jsd MATRIX
METALLOPROTEINASE-20
(Homo
sapiens)		4 / 5HIS A 226
GLU A 227
HIS A 230
HIS A 236
NGH  A 277 ( 3.0A)
NGH  A 277 (-3.6A)
ZN  A 276 ( 3.3A)
ZN  A 276 ( 3.0A)
0.58A58.18
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3KEC_A_HAEA272_1
(COLLAGENASE 3)		2oy4 NEUTROPHIL
COLLAGENASE
(Homo
sapiens)		4 / 5HIS A 197
GLU A 198
HIS A 201
HIS A 207
 ZN  A 999 (-3.2A)
ZN  A 999 ( 4.4A)
ZN  A 999 (-3.4A)
ZN  A 999 (-3.2A)
0.12A60.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KEC_A_HAEA272_1
(COLLAGENASE 3)		2rjq ADAMTS-5
(Homo
sapiens)		4 / 5HIS A 410
GLU A 411
HIS A 414
HIS A 420
 ZN  A   1 ( 3.2A)
BAT  A 559 (-2.5A)
ZN  A   1 ( 3.3A)
ZN  A   1 ( 3.3A)
0.18A18.60
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3KEC_A_HAEA272_1
(COLLAGENASE 3)		2y6c MATRILYSIN
(Homo
sapiens)		4 / 5HIS A 219
GLU A 220
HIS A 223
HIS A 229
 ZN  A1267 ( 3.2A)
TQI  A1269 (-2.9A)
ZN  A1267 ( 3.3A)
ZN  A1267 ( 3.2A)
0.20A52.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KEC_A_HAEA272_1
(COLLAGENASE 3)		3b8z PROTEIN ADAMTS-5
(Homo
sapiens)		4 / 5HIS A 410
GLU A 411
HIS A 414
HIS A 420
 ZN  A 901 ( 3.2A)
294  A 801 (-2.7A)
ZN  A 901 ( 3.3A)
ZN  A 901 ( 3.3A)
0.23A23.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KEC_A_HAEA272_1
(COLLAGENASE 3)		3ba0 MACROPHAGE
METALLOELASTASE
(Homo
sapiens)		4 / 5HIS A 218
GLU A 219
HIS A 222
HIS A 228
 ZN  A 471 (-4.0A)
ZN  A 471 ( 3.2A)
HAE  A 477 ( 3.1A)
ZN  A 471 (-3.7A)
0.36A28.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KEC_A_HAEA272_1
(COLLAGENASE 3)		3edi TOLLOID-LIKE PROTEIN
1
(Homo
sapiens)		4 / 5HIS A  92
GLU A  93
HIS A  96
HIS A 102
 ZN  A 210 (-3.2A)
ZN  A 210 ( 4.3A)
ZN  A 210 (-3.3A)
ZN  A 210 (-3.2A)
0.15A22.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KEC_A_HAEA272_1
(COLLAGENASE 3)		3lgg ADENOSINE DEAMINASE
CECR1
(Homo
sapiens)		4 / 5LEU A 389
HIS A  86
HIS A  88
HIS A 330
None
ZN  A 512 (-3.4A)
CFE  A 513 ( 3.3A)
ZN  A 512 ( 3.5A)
0.98A15.01
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3KEC_A_HAEA272_1
(COLLAGENASE 3)		3o2x COLLAGENASE 3
(Homo
sapiens)		4 / 5HIS A1222
GLU A1223
HIS A1226
HIS A1232
 ZN  A1999 ( 3.2A)
3O2  A1801 (-2.7A)
ZN  A1999 ( 3.4A)
ZN  A1999 ( 3.2A)
0.17A99.39
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3KEC_A_HAEA272_1
(COLLAGENASE 3)		3o2x COLLAGENASE 3
(Homo
sapiens)		4 / 5LEU A1184
HIS A1222
HIS A1226
HIS A1232
3O2  A1801 ( 4.5A)
ZN  A1999 ( 3.2A)
ZN  A1999 ( 3.4A)
ZN  A1999 ( 3.2A)
0.76A99.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KEC_A_HAEA272_1
(COLLAGENASE 3)		3q2h A DISINTEGRIN AND
METALLOPROTEINASE
WITH THROMBOSPONDIN
MOTIFS 1
(Homo
sapiens)		4 / 5HIS A 149
GLU A 150
HIS A 153
HIS A 159
 ZN  A 401 ( 3.3A)
QHF  A   1 (-2.6A)
QHF  A   1 ( 3.0A)
ZN  A 401 ( 3.2A)
0.20A20.68
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3KEC_A_HAEA272_1
(COLLAGENASE 3)		3shi INTERSTITIAL
COLLAGENASE
(Homo
sapiens)		4 / 5HIS A 218
GLU A 219
HIS A 222
HIS A 228
 ZN  A 301 (-3.3A)
ZN  A 301 ( 4.7A)
ZN  A 301 (-3.4A)
ZN  A 301 (-3.3A)
0.27A58.28
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3KEC_A_HAEA272_1
(COLLAGENASE 3)		3v96 STROMELYSIN-2
(Homo
sapiens)		4 / 5HIS B 217
GLU B 218
HIS B 221
HIS B 227
 ZN  B 301 (-3.2A)
ZN  B 301 ( 3.9A)
ZN  B 301 (-3.3A)
ZN  B 301 (-3.2A)
0.22A62.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KEC_A_HAEA272_1
(COLLAGENASE 3)		4dd8 DISINTEGRIN AND
METALLOPROTEINASE
DOMAIN-CONTAINING
PROTEIN 8
(Homo
sapiens)		4 / 5HIS A 334
GLU A 335
HIS A 338
HIS A 344
 ZN  A1002 ( 3.3A)
BAT  A1000 (-2.7A)
ZN  A1002 (-3.3A)
ZN  A1002 ( 3.3A)
0.38A22.02
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3KEC_A_HAEA272_1
(COLLAGENASE 3)		4gr8 MACROPHAGE
METALLOELASTASE
(Homo
sapiens)		4 / 5HIS A 218
GLU A 219
HIS A 222
HIS A 228
R4C  A 306 ( 3.2A)
R4C  A 306 (-2.7A)
ZN  A 301 ( 3.2A)
ZN  A 301 ( 3.2A)
0.28A58.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KEC_A_HAEA272_1
(COLLAGENASE 3)		4gwn MEPRIN A SUBUNIT
BETA
(Homo
sapiens)		4 / 5HIS A 152
GLU A 153
HIS A 156
HIS A 162
 CD  A 701 (-3.7A)
CD  A 701 (-3.5A)
CD  A 701 (-3.7A)
CD  A 701 (-3.7A)
0.24A16.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KEC_A_HAEA272_1
(COLLAGENASE 3)		4wk7 A DISINTEGRIN AND
METALLOPROTEINASE
WITH THROMBOSPONDIN
MOTIFS 4
(Homo
sapiens)		4 / 5HIS A 361
GLU A 362
HIS A 365
HIS A 371
 ZN  A 501 ( 3.2A)
3PQ  A 505 (-2.6A)
ZN  A 501 ( 3.3A)
ZN  A 501 ( 3.2A)
0.28A24.90
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3KEC_A_HAEA272_1
(COLLAGENASE 3)		4xct MATRIX
METALLOPROTEINASE-9,
MATRIX
METALLOPROTEINASE-9
(Homo
sapiens)		4 / 5HIS A 226
GLU A 227
HIS A 230
HIS A 236
 ZN  A 302 ( 3.2A)
N73  A 301 (-2.5A)
ZN  A 302 ( 3.3A)
ZN  A 302 ( 3.3A)
0.15A57.83
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3KEC_A_HAEA272_1
(COLLAGENASE 3)		4xct MATRIX
METALLOPROTEINASE-9,
MATRIX
METALLOPROTEINASE-9
(Homo
sapiens)		4 / 5LEU A 187
HIS A 226
HIS A 230
HIS A 236
N73  A 301 (-4.0A)
ZN  A 302 ( 3.2A)
ZN  A 302 ( 3.3A)
ZN  A 302 ( 3.3A)
0.74A57.83
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3KEC_A_HAEA272_1
(COLLAGENASE 3)		5h0u MATRIX
METALLOPROTEINASE-14
(Homo
sapiens)		4 / 5HIS A 239
GLU A 240
HIS A 243
HIS A 249
 ZN  A 302 ( 3.3A)
GOL  A 311 (-4.2A)
ZN  A 302 (-3.4A)
ZN  A 302 (-3.2A)
0.12A48.02
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3KEC_A_HAEA272_1
(COLLAGENASE 3)		5th6 MATRIX
METALLOPROTEINASE-9,
MATRIX
METALLOPROTEINASE-9
(Homo
sapiens)		4 / 5HIS A 401
GLU A 402
HIS A 405
HIS A 411
 ZN  A 501 (-3.3A)
ZN  A 501 ( 4.2A)
ZN  A 501 (-3.2A)
ZN  A 501 (-3.1A)
0.15A44.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KEC_A_HAEA272_1
(COLLAGENASE 3)		6bdz DISINTEGRIN AND
METALLOPROTEINASE
DOMAIN-CONTAINING
PROTEIN 10
(Homo
sapiens)		4 / 5HIS A 383
GLU A 384
HIS A 387
HIS A 393
 ZN  A 705 (-3.3A)
ZN  A 705 (-3.8A)
ZN  A 705 (-4.0A)
ZN  A 705 (-3.2A)
0.42A18.67
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3KEC_B_HAEB271_1
(COLLAGENASE 3)		1hfs STROMELYSIN-1
(Homo
sapiens)		3 / 3HIS A 201
GLU A 202
HIS A 205
 ZN  A 257 ( 3.1A)
L04  A 256 ( 2.7A)
ZN  A 257 ( 3.2A)
0.22A61.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KEC_B_HAEB271_1
(COLLAGENASE 3)		1l6j MATRIX
METALLOPROTEINASE-9
(Homo
sapiens)		3 / 3HIS A 401
GLU A 402
HIS A 405
 ZN  A 500 (-3.4A)
ZN  A 500 ( 4.3A)
ZN  A 500 (-3.2A)
0.14A24.12
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3KEC_B_HAEB271_1
(COLLAGENASE 3)		1rm8 MATRIX
METALLOPROTEINASE-16
(Homo
sapiens)		3 / 3HIS A 246
GLU A 247
HIS A 250
 ZN  A 500 ( 3.3A)
BAT  A 800 (-2.7A)
ZN  A 500 ( 3.2A)
0.21A48.57
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3KEC_B_HAEB271_1
(COLLAGENASE 3)		1slm STROMELYSIN-1
(Homo
sapiens)		3 / 3HIS A 201
GLU A 202
HIS A 205
 ZN  A 257 ( 3.0A)
ZN  A 257 ( 4.1A)
ZN  A 257 ( 3.2A)
0.11A43.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KEC_B_HAEB271_1
(COLLAGENASE 3)		2o36 THIMET
OLIGOPEPTIDASE
(Homo
sapiens)		3 / 3HIS A 473
GLU A 474
HIS A 477
 ZN  A 690 (-3.4A)
ZN  A 690 ( 4.1A)
ZN  A 690 (-3.3A)
0.19A13.94
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3KEC_B_HAEB271_1
(COLLAGENASE 3)		2oy4 NEUTROPHIL
COLLAGENASE
(Homo
sapiens)		3 / 3HIS A 197
GLU A 198
HIS A 201
 ZN  A 999 (-3.2A)
ZN  A 999 ( 4.4A)
ZN  A 999 (-3.4A)
0.14A60.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KEC_B_HAEB271_1
(COLLAGENASE 3)		2rjq ADAMTS-5
(Homo
sapiens)		3 / 3HIS A 410
GLU A 411
HIS A 414
 ZN  A   1 ( 3.2A)
BAT  A 559 (-2.5A)
ZN  A   1 ( 3.3A)
0.17A18.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KEC_B_HAEB271_1
(COLLAGENASE 3)		2xy9 ANGIOTENSIN-CONVERTI
NG ENZYME
(Homo
sapiens)		3 / 3HIS A 383
GLU A 384
HIS A 387
 ZN  A1628 ( 3.2A)
3ES  A1635 (-2.8A)
ZN  A1628 ( 3.2A)
0.10A15.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KEC_B_HAEB271_1
(COLLAGENASE 3)		2xyd ANGIOTENSIN-CONVERTI
NG ENZYME
(Homo
sapiens)		3 / 3HIS A 361
GLU A 362
HIS A 365
3ES  A1611 ( 3.2A)
3ES  A1611 (-2.5A)
ZN  A1620 ( 3.2A)
0.12A14.77
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3KEC_B_HAEB271_1
(COLLAGENASE 3)		2y6c MATRILYSIN
(Homo
sapiens)		3 / 3HIS A 219
GLU A 220
HIS A 223
 ZN  A1267 ( 3.2A)
TQI  A1269 (-2.9A)
ZN  A1267 ( 3.3A)
0.14A52.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KEC_B_HAEB271_1
(COLLAGENASE 3)		2yd0 ENDOPLASMIC
RETICULUM
AMINOPEPTIDASE 1
(Homo
sapiens)		3 / 3HIS A 353
GLU A 354
HIS A 357
 ZN  A1946 ( 3.3A)
BES  A1950 (-3.3A)
BES  A1950 ( 3.3A)
0.17A11.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KEC_B_HAEB271_1
(COLLAGENASE 3)		3b8z PROTEIN ADAMTS-5
(Homo
sapiens)		3 / 3HIS A 410
GLU A 411
HIS A 414
 ZN  A 901 ( 3.2A)
294  A 801 (-2.7A)
ZN  A 901 ( 3.3A)
0.13A23.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KEC_B_HAEB271_1
(COLLAGENASE 3)		3dwb ENDOTHELIN-CONVERTIN
G ENZYME 1
(Homo
sapiens)		3 / 3HIS A 607
GLU A 608
HIS A 611
 ZN  A 771 ( 3.4A)
RDF  A 817 (-2.4A)
ZN  A 771 ( 3.3A)
0.20A13.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KEC_B_HAEB271_1
(COLLAGENASE 3)		3edi TOLLOID-LIKE PROTEIN
1
(Homo
sapiens)		3 / 3HIS A  92
GLU A  93
HIS A  96
 ZN  A 210 (-3.2A)
ZN  A 210 ( 4.3A)
ZN  A 210 (-3.3A)
0.11A22.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KEC_B_HAEB271_1
(COLLAGENASE 3)		3g5k PEPTIDE DEFORMYLASE,
MITOCHONDRIAL
(Homo
sapiens)		3 / 3HIS A 156
GLU A 157
HIS A 160
 CO  A1002 ( 3.2A)
BB2  A1001 (-2.6A)
CO  A1002 ( 3.3A)
0.19A18.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KEC_B_HAEB271_1
(COLLAGENASE 3)		3kbh ANGIOTENSIN-CONVERTI
NG ENZYME 2
(Homo
sapiens)		3 / 3HIS A 374
GLU A 375
HIS A 378
None
0.18A16.17
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3KEC_B_HAEB271_1
(COLLAGENASE 3)		3o2x COLLAGENASE 3
(Homo
sapiens)		3 / 3HIS A1222
GLU A1223
HIS A1226
 ZN  A1999 ( 3.2A)
3O2  A1801 (-2.7A)
ZN  A1999 ( 3.4A)
0.07A99.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KEC_B_HAEB271_1
(COLLAGENASE 3)		3q2h A DISINTEGRIN AND
METALLOPROTEINASE
WITH THROMBOSPONDIN
MOTIFS 1
(Homo
sapiens)		3 / 3HIS A 149
GLU A 150
HIS A 153
 ZN  A 401 ( 3.3A)
QHF  A   1 (-2.6A)
QHF  A   1 ( 3.0A)
0.22A20.68
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3KEC_B_HAEB271_1
(COLLAGENASE 3)		3v96 STROMELYSIN-2
(Homo
sapiens)		3 / 3HIS B 217
GLU B 218
HIS B 221
 ZN  B 301 (-3.2A)
ZN  B 301 ( 3.9A)
ZN  B 301 (-3.3A)
0.14A62.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KEC_B_HAEB271_1
(COLLAGENASE 3)		3zus BOTULINUM NEUROTOXIN
TYPE A,
SYNAPTOSOMAL-ASSOCIA
TED PROTEIN 23
(Clostridium
botulinum;
Homo
sapiens)		3 / 3HIS A 223
GLU A 224
HIS A 227
 ZN  A1916 (-3.3A)
ZN  A1916 ( 4.3A)
ZN  A1916 (-3.3A)
0.19A10.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KEC_B_HAEB271_1
(COLLAGENASE 3)		4fys AMINOPEPTIDASE N
(Homo
sapiens)		3 / 3HIS A 388
GLU A 389
HIS A 392
None
0.19A11.83
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3KEC_B_HAEB271_1
(COLLAGENASE 3)		4gr8 MACROPHAGE
METALLOELASTASE
(Homo
sapiens)		3 / 3HIS A 218
GLU A 219
HIS A 222
R4C  A 306 ( 3.2A)
R4C  A 306 (-2.7A)
ZN  A 301 ( 3.2A)
0.13A58.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KEC_B_HAEB271_1
(COLLAGENASE 3)		4gwn MEPRIN A SUBUNIT
BETA
(Homo
sapiens)		3 / 3HIS A 152
GLU A 153
HIS A 156
 CD  A 701 (-3.7A)
CD  A 701 (-3.5A)
CD  A 701 (-3.7A)
0.13A16.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KEC_B_HAEB271_1
(COLLAGENASE 3)		4kxb GLUTAMYL
AMINOPEPTIDASE
(Homo
sapiens)		3 / 3HIS A 393
GLU A 394
HIS A 397
 ZN  A1001 ( 3.3A)
BES  A1017 (-3.1A)
ZN  A1001 ( 3.2A)
0.21A12.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KEC_B_HAEB271_1
(COLLAGENASE 3)		4wk7 A DISINTEGRIN AND
METALLOPROTEINASE
WITH THROMBOSPONDIN
MOTIFS 4
(Homo
sapiens)		3 / 3HIS A 361
GLU A 362
HIS A 365
 ZN  A 501 ( 3.2A)
3PQ  A 505 (-2.6A)
ZN  A 501 ( 3.3A)
0.20A24.90
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3KEC_B_HAEB271_1
(COLLAGENASE 3)		4xct MATRIX
METALLOPROTEINASE-9,
MATRIX
METALLOPROTEINASE-9
(Homo
sapiens)		3 / 3HIS A 226
GLU A 227
HIS A 230
 ZN  A 302 ( 3.2A)
N73  A 301 (-2.5A)
ZN  A 302 ( 3.3A)
0.11A57.83
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3KEC_B_HAEB271_1
(COLLAGENASE 3)		5h0u MATRIX
METALLOPROTEINASE-14
(Homo
sapiens)		3 / 3HIS A 239
GLU A 240
HIS A 243
 ZN  A 302 ( 3.3A)
GOL  A 311 (-4.2A)
ZN  A 302 (-3.4A)
0.12A48.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KEC_B_HAEB271_1
(COLLAGENASE 3)		5syt CAAX PRENYL PROTEASE
1 HOMOLOG
(Homo
sapiens)		3 / 3HIS A 335
GLU A 336
HIS A 339
 ZN  A 517 (-3.2A)
ZN  A 517 (-3.9A)
ZN  A 517 (-3.2A)
0.22A15.93
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3KEC_B_HAEB271_1
(COLLAGENASE 3)		5th6 MATRIX
METALLOPROTEINASE-9,
MATRIX
METALLOPROTEINASE-9
(Homo
sapiens)		3 / 3HIS A 401
GLU A 402
HIS A 405
 ZN  A 501 (-3.3A)
ZN  A 501 ( 4.2A)
ZN  A 501 (-3.2A)
0.15A44.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LIK_A_HAEA302_1
(MACROPHAGE
METALLOELASTASE)		1ck7 PROTEIN (GELATINASE
A)
(Homo
sapiens)		4 / 5HIS A 193
HIS A 403
HIS A 407
HIS A 413
 ZN  A 991 ( 3.1A)
ZN  A 990 ( 3.4A)
ZN  A 990 ( 3.3A)
ZN  A 990 ( 3.4A)
0.45A26.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LIK_A_HAEA302_1
(MACROPHAGE
METALLOELASTASE)		1eak 72 KDA TYPE IV
COLLAGENASE
(Homo
sapiens)		4 / 5HIS A 193
HIS A 403
HIS A 407
HIS A 413
 ZN  A 996 (-3.1A)
ZN  A 997 (-3.5A)
ZN  A 997 (-3.6A)
ZN  A 997 (-3.5A)
0.39A26.88
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3LIK_A_HAEA302_1
(MACROPHAGE
METALLOELASTASE)		1hfs STROMELYSIN-1
(Homo
sapiens)		5 / 5HIS A 166
HIS A 201
GLU A 202
HIS A 205
HIS A 211
 ZN  A 258 ( 3.0A)
ZN  A 257 ( 3.1A)
L04  A 256 ( 2.7A)
ZN  A 257 ( 3.2A)
ZN  A 257 ( 3.1A)
0.59A58.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LIK_A_HAEA302_1
(MACROPHAGE
METALLOELASTASE)		1l6j MATRIX
METALLOPROTEINASE-9
(Homo
sapiens)		5 / 5HIS A 190
HIS A 401
GLU A 402
HIS A 405
HIS A 411
 ZN  A 501 (-3.4A)
ZN  A 500 (-3.4A)
ZN  A 500 ( 4.3A)
ZN  A 500 (-3.2A)
ZN  A 500 (-3.4A)
0.32A23.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3LIK_A_HAEA302_1
(MACROPHAGE
METALLOELASTASE)		1qib 72 KDA TYPE IV
COLLAGENASE
(Homo
sapiens)		5 / 5HIS A 166
HIS A 201
GLU A 202
HIS A 205
HIS A 211
 ZN  A 502 (-3.5A)
ZN  A 501 (-3.5A)
ZN  A 501 ( 4.5A)
ZN  A 501 (-3.5A)
ZN  A 501 (-3.5A)
0.35A59.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LIK_A_HAEA302_1
(MACROPHAGE
METALLOELASTASE)		1r55 ADAM 33
(Homo
sapiens)		4 / 5HIS A 345
GLU A 346
HIS A 349
HIS A 355
 ZN  A 201 ( 3.3A)
097  A 518 (-2.9A)
ZN  A 201 ( 3.2A)
ZN  A 201 ( 3.3A)
0.30A25.33
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3LIK_A_HAEA302_1
(MACROPHAGE
METALLOELASTASE)		1rm8 MATRIX
METALLOPROTEINASE-16
(Homo
sapiens)		5 / 5HIS A 208
HIS A 246
GLU A 247
HIS A 250
HIS A 256
 ZN  A 501 (-3.2A)
ZN  A 500 ( 3.3A)
BAT  A 800 (-2.7A)
ZN  A 500 ( 3.2A)
ZN  A 500 ( 3.3A)
0.26A50.89
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3LIK_A_HAEA302_1
(MACROPHAGE
METALLOELASTASE)		1slm STROMELYSIN-1
(Homo
sapiens)		5 / 5HIS A 166
HIS A 201
GLU A 202
HIS A 205
HIS A 211
 ZN  A 258 ( 3.0A)
ZN  A 257 ( 3.0A)
ZN  A 257 ( 4.1A)
ZN  A 257 ( 3.2A)
ZN  A 257 ( 3.1A)
0.34A41.45
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3LIK_A_HAEA302_1
(MACROPHAGE
METALLOELASTASE)		1su3 INTERSTITIAL
COLLAGENASE
(Homo
sapiens)		4 / 5HIS A 183
HIS A 218
HIS A 222
HIS A 228
 ZN  A 915 (-3.3A)
ZN  A 913 (-3.2A)
ZN  A 913 (-3.2A)
ZN  A 913 (-3.2A)
0.28A38.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LIK_A_HAEA302_1
(MACROPHAGE
METALLOELASTASE)		1xcr HYPOTHETICAL PROTEIN
PTD012
(Homo
sapiens)		4 / 5HIS A 268
GLU A 110
HIS A 278
HIS A 266
 ZN  A1001 ( 3.2A)
ACY  A2001 ( 3.7A)
ZN  A1001 ( 3.2A)
ZN  A1001 ( 3.2A)
0.95A21.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LIK_A_HAEA302_1
(MACROPHAGE
METALLOELASTASE)		2fv5 ADAM 17
(Homo
sapiens)		4 / 5HIS A 405
GLU A 406
HIS A 409
HIS A 415
 ZN  A   3 ( 3.2A)
541  A   1 (-2.6A)
ZN  A   3 ( 3.3A)
ZN  A   3 ( 3.2A)
0.27A23.08
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3LIK_A_HAEA302_1
(MACROPHAGE
METALLOELASTASE)		2jsd MATRIX
METALLOPROTEINASE-20
(Homo
sapiens)		5 / 5HIS A 191
HIS A 226
GLU A 227
HIS A 230
HIS A 236
 ZN  A 275 (-3.4A)
NGH  A 277 ( 3.0A)
NGH  A 277 (-3.6A)
ZN  A 276 ( 3.3A)
ZN  A 276 ( 3.0A)
0.70A54.09
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3LIK_A_HAEA302_1
(MACROPHAGE
METALLOELASTASE)		2oy4 NEUTROPHIL
COLLAGENASE
(Homo
sapiens)		5 / 5HIS A 162
HIS A 197
GLU A 198
HIS A 201
HIS A 207
 ZN  A 998 (-3.3A)
ZN  A 999 (-3.2A)
ZN  A 999 ( 4.4A)
ZN  A 999 (-3.4A)
ZN  A 999 (-3.2A)
0.28A53.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LIK_A_HAEA302_1
(MACROPHAGE
METALLOELASTASE)		2rjq ADAMTS-5
(Homo
sapiens)		4 / 5HIS A 410
GLU A 411
HIS A 414
HIS A 420
 ZN  A   1 ( 3.2A)
BAT  A 559 (-2.5A)
ZN  A   1 ( 3.3A)
ZN  A   1 ( 3.3A)
0.15A15.80
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3LIK_A_HAEA302_1
(MACROPHAGE
METALLOELASTASE)		2y6c MATRILYSIN
(Homo
sapiens)		5 / 5HIS A 183
HIS A 219
GLU A 220
HIS A 223
HIS A 229
 ZN  A1266 ( 3.3A)
ZN  A1267 ( 3.2A)
TQI  A1269 (-2.9A)
ZN  A1267 ( 3.3A)
ZN  A1267 ( 3.2A)
0.43A53.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LIK_A_HAEA302_1
(MACROPHAGE
METALLOELASTASE)		3b8z PROTEIN ADAMTS-5
(Homo
sapiens)		4 / 5HIS A 410
GLU A 411
HIS A 414
HIS A 420
 ZN  A 901 ( 3.2A)
294  A 801 (-2.7A)
ZN  A 901 ( 3.3A)
ZN  A 901 ( 3.3A)
0.13A23.72
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3LIK_A_HAEA302_1
(MACROPHAGE
METALLOELASTASE)		3ba0 MACROPHAGE
METALLOELASTASE
(Homo
sapiens)		5 / 5HIS A 183
HIS A 218
GLU A 219
HIS A 222
HIS A 228
 ZN  A 472 (-3.1A)
ZN  A 471 (-4.0A)
ZN  A 471 ( 3.2A)
HAE  A 477 ( 3.1A)
ZN  A 471 (-3.7A)
0.73A100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LIK_A_HAEA302_1
(MACROPHAGE
METALLOELASTASE)		3edi TOLLOID-LIKE PROTEIN
1
(Homo
sapiens)		4 / 5HIS A  92
GLU A  93
HIS A  96
HIS A 102
 ZN  A 210 (-3.2A)
ZN  A 210 ( 4.3A)
ZN  A 210 (-3.3A)
ZN  A 210 (-3.2A)
0.16A23.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LIK_A_HAEA302_1
(MACROPHAGE
METALLOELASTASE)		3hig AMILORIDE-SENSITIVE
AMINE OXIDASE
(Homo
sapiens)		4 / 5HIS A 486
HIS A 512
HIS A 510
HIS A 675
None
CU  A 801 (-3.2A)
CU  A 801 (-3.3A)
CU  A 801 (-3.0A)
0.98A11.71
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3LIK_A_HAEA302_1
(MACROPHAGE
METALLOELASTASE)		3o2x COLLAGENASE 3
(Homo
sapiens)		5 / 5HIS A1187
HIS A1222
GLU A1223
HIS A1226
HIS A1232
 ZN  A1998 ( 3.2A)
ZN  A1999 ( 3.2A)
3O2  A1801 (-2.7A)
ZN  A1999 ( 3.4A)
ZN  A1999 ( 3.2A)
0.36A56.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LIK_A_HAEA302_1
(MACROPHAGE
METALLOELASTASE)		3q2h A DISINTEGRIN AND
METALLOPROTEINASE
WITH THROMBOSPONDIN
MOTIFS 1
(Homo
sapiens)		4 / 5HIS A 149
GLU A 150
HIS A 153
HIS A 159
 ZN  A 401 ( 3.3A)
QHF  A   1 (-2.6A)
QHF  A   1 ( 3.0A)
ZN  A 401 ( 3.2A)
0.20A18.87
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3LIK_A_HAEA302_1
(MACROPHAGE
METALLOELASTASE)		3shi INTERSTITIAL
COLLAGENASE
(Homo
sapiens)		5 / 5HIS A 183
HIS A 218
GLU A 219
HIS A 222
HIS A 228
 ZN  A 302 (-3.1A)
ZN  A 301 (-3.3A)
ZN  A 301 ( 4.7A)
ZN  A 301 (-3.4A)
ZN  A 301 (-3.3A)
0.40A57.67
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3LIK_A_HAEA302_1
(MACROPHAGE
METALLOELASTASE)		3v96 STROMELYSIN-2
(Homo
sapiens)		5 / 5HIS B 182
HIS B 217
GLU B 218
HIS B 221
HIS B 227
 ZN  B 302 (-3.2A)
ZN  B 301 (-3.2A)
ZN  B 301 ( 3.9A)
ZN  B 301 (-3.3A)
ZN  B 301 (-3.2A)
0.38A55.76
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3LIK_A_HAEA302_1
(MACROPHAGE
METALLOELASTASE)		4auo INTERSTITIAL
COLLAGENASE
(Homo
sapiens)		4 / 5HIS A 164
HIS A 199
HIS A 203
HIS A 209
 ZN  A1201 (-3.1A)
ZN  A1202 (-3.0A)
ZN  A1202 (-3.1A)
ZN  A1202 (-3.4A)
0.29A55.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LIK_A_HAEA302_1
(MACROPHAGE
METALLOELASTASE)		4dd8 DISINTEGRIN AND
METALLOPROTEINASE
DOMAIN-CONTAINING
PROTEIN 8
(Homo
sapiens)		4 / 5HIS A 334
GLU A 335
HIS A 338
HIS A 344
 ZN  A1002 ( 3.3A)
BAT  A1000 (-2.7A)
ZN  A1002 (-3.3A)
ZN  A1002 ( 3.3A)
0.40A18.52
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3LIK_A_HAEA302_1
(MACROPHAGE
METALLOELASTASE)		4fvl COLLAGENASE 3
(Homo
sapiens)		4 / 5HIS A 187
HIS A 222
HIS A 226
HIS A 232
 ZN  A 502 (-3.3A)
ZN  A 501 (-3.3A)
ZN  A 501 (-3.1A)
ZN  A 501 (-3.2A)
0.51A55.49
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3LIK_A_HAEA302_1
(MACROPHAGE
METALLOELASTASE)		4gr8 MACROPHAGE
METALLOELASTASE
(Homo
sapiens)		5 / 5HIS A 183
HIS A 218
GLU A 219
HIS A 222
HIS A 228
 ZN  A 302 (-3.2A)
R4C  A 306 ( 3.2A)
R4C  A 306 (-2.7A)
ZN  A 301 ( 3.2A)
ZN  A 301 ( 3.2A)
0.40A100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LIK_A_HAEA302_1
(MACROPHAGE
METALLOELASTASE)		4gwn MEPRIN A SUBUNIT
BETA
(Homo
sapiens)		4 / 5HIS A 152
GLU A 153
HIS A 156
HIS A 162
 CD  A 701 (-3.7A)
CD  A 701 (-3.5A)
CD  A 701 (-3.7A)
CD  A 701 (-3.7A)
0.28A13.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LIK_A_HAEA302_1
(MACROPHAGE
METALLOELASTASE)		4qgn 1,2-DIHYDROXY-3-KETO
-5-METHYLTHIOPENTENE
DIOXYGENASE
(Homo
sapiens)		4 / 5HIS A 133
GLU A  94
HIS A  90
HIS A  88
 FE  A 201 (-3.3A)
FE  A 201 ( 2.7A)
FE  A 201 (-3.3A)
FE  A 201 (-3.4A)
1.05A20.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LIK_A_HAEA302_1
(MACROPHAGE
METALLOELASTASE)		4wk7 A DISINTEGRIN AND
METALLOPROTEINASE
WITH THROMBOSPONDIN
MOTIFS 4
(Homo
sapiens)		4 / 5HIS A 361
GLU A 362
HIS A 365
HIS A 371
 ZN  A 501 ( 3.2A)
3PQ  A 505 (-2.6A)
ZN  A 501 ( 3.3A)
ZN  A 501 ( 3.2A)
0.24A19.67
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3LIK_A_HAEA302_1
(MACROPHAGE
METALLOELASTASE)		4xct MATRIX
METALLOPROTEINASE-9,
MATRIX
METALLOPROTEINASE-9
(Homo
sapiens)		5 / 5HIS A 190
HIS A 226
GLU A 227
HIS A 230
HIS A 236
 ZN  A 303 ( 3.2A)
ZN  A 302 ( 3.2A)
N73  A 301 (-2.5A)
ZN  A 302 ( 3.3A)
ZN  A 302 ( 3.3A)
0.29A50.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3LIK_A_HAEA302_1
(MACROPHAGE
METALLOELASTASE)		5h0u MATRIX
METALLOPROTEINASE-14
(Homo
sapiens)		5 / 5HIS A 201
HIS A 239
GLU A 240
HIS A 243
HIS A 249
 ZN  A 303 (-3.2A)
ZN  A 302 ( 3.3A)
GOL  A 311 (-4.2A)
ZN  A 302 (-3.4A)
ZN  A 302 (-3.2A)
0.43A50.89
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3LIK_A_HAEA302_1
(MACROPHAGE
METALLOELASTASE)		5th6 MATRIX
METALLOPROTEINASE-9,
MATRIX
METALLOPROTEINASE-9
(Homo
sapiens)		5 / 5HIS A 190
HIS A 401
GLU A 402
HIS A 405
HIS A 411
 ZN  A 502 (-3.2A)
ZN  A 501 (-3.3A)
ZN  A 501 ( 4.2A)
ZN  A 501 (-3.2A)
ZN  A 501 (-3.1A)
0.29A35.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LIK_A_HAEA302_1
(MACROPHAGE
METALLOELASTASE)		6bdz DISINTEGRIN AND
METALLOPROTEINASE
DOMAIN-CONTAINING
PROTEIN 10
(Homo
sapiens)		4 / 5HIS A 383
GLU A 384
HIS A 387
HIS A 393
 ZN  A 705 (-3.3A)
ZN  A 705 (-3.8A)
ZN  A 705 (-4.0A)
ZN  A 705 (-3.2A)
0.46A19.87
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3LIL_A_HAEA302_1
(MACROPHAGE
METALLOELASTASE)		1hfs STROMELYSIN-1
(Homo
sapiens)		4 / 4HIS A 201
GLU A 202
HIS A 205
HIS A 211
 ZN  A 257 ( 3.1A)
L04  A 256 ( 2.7A)
ZN  A 257 ( 3.2A)
ZN  A 257 ( 3.1A)
0.21A58.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LIL_A_HAEA302_1
(MACROPHAGE
METALLOELASTASE)		1l6j MATRIX
METALLOPROTEINASE-9
(Homo
sapiens)		4 / 4HIS A 401
GLU A 402
HIS A 405
HIS A 411
 ZN  A 500 (-3.4A)
ZN  A 500 ( 4.3A)
ZN  A 500 (-3.2A)
ZN  A 500 (-3.4A)
0.22A23.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3LIL_A_HAEA302_1
(MACROPHAGE
METALLOELASTASE)		1qib 72 KDA TYPE IV
COLLAGENASE
(Homo
sapiens)		4 / 4HIS A 201
GLU A 202
HIS A 205
HIS A 211
 ZN  A 501 (-3.5A)
ZN  A 501 ( 4.5A)
ZN  A 501 (-3.5A)
ZN  A 501 (-3.5A)
0.31A59.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LIL_A_HAEA302_1
(MACROPHAGE
METALLOELASTASE)		1r55 ADAM 33
(Homo
sapiens)		4 / 4HIS A 345
GLU A 346
HIS A 349
HIS A 355
 ZN  A 201 ( 3.3A)
097  A 518 (-2.9A)
ZN  A 201 ( 3.2A)
ZN  A 201 ( 3.3A)
0.31A25.33
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3LIL_A_HAEA302_1
(MACROPHAGE
METALLOELASTASE)		1rm8 MATRIX
METALLOPROTEINASE-16
(Homo
sapiens)		4 / 4HIS A 246
GLU A 247
HIS A 250
HIS A 256
 ZN  A 500 ( 3.3A)
BAT  A 800 (-2.7A)
ZN  A 500 ( 3.2A)
ZN  A 500 ( 3.3A)
0.20A50.89
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3LIL_A_HAEA302_1
(MACROPHAGE
METALLOELASTASE)		1slm STROMELYSIN-1
(Homo
sapiens)		4 / 4HIS A 201
GLU A 202
HIS A 205
HIS A 211
 ZN  A 257 ( 3.0A)
ZN  A 257 ( 4.1A)
ZN  A 257 ( 3.2A)
ZN  A 257 ( 3.1A)
0.25A41.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LIL_A_HAEA302_1
(MACROPHAGE
METALLOELASTASE)		1xcr HYPOTHETICAL PROTEIN
PTD012
(Homo
sapiens)		4 / 4HIS A 268
GLU A 110
HIS A 278
HIS A 266
 ZN  A1001 ( 3.2A)
ACY  A2001 ( 3.7A)
ZN  A1001 ( 3.2A)
ZN  A1001 ( 3.2A)
0.95A21.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LIL_A_HAEA302_1
(MACROPHAGE
METALLOELASTASE)		2fv5 ADAM 17
(Homo
sapiens)		4 / 4HIS A 405
GLU A 406
HIS A 409
HIS A 415
 ZN  A   3 ( 3.2A)
541  A   1 (-2.6A)
ZN  A   3 ( 3.3A)
ZN  A   3 ( 3.2A)
0.28A23.08
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3LIL_A_HAEA302_1
(MACROPHAGE
METALLOELASTASE)		2jsd MATRIX
METALLOPROTEINASE-20
(Homo
sapiens)		4 / 4HIS A 226
GLU A 227
HIS A 230
HIS A 236
NGH  A 277 ( 3.0A)
NGH  A 277 (-3.6A)
ZN  A 276 ( 3.3A)
ZN  A 276 ( 3.0A)
0.61A54.09
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3LIL_A_HAEA302_1
(MACROPHAGE
METALLOELASTASE)		2oy4 NEUTROPHIL
COLLAGENASE
(Homo
sapiens)		4 / 4HIS A 197
GLU A 198
HIS A 201
HIS A 207
 ZN  A 999 (-3.2A)
ZN  A 999 ( 4.4A)
ZN  A 999 (-3.4A)
ZN  A 999 (-3.2A)
0.14A53.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LIL_A_HAEA302_1
(MACROPHAGE
METALLOELASTASE)		2rjq ADAMTS-5
(Homo
sapiens)		4 / 4HIS A 410
GLU A 411
HIS A 414
HIS A 420
 ZN  A   1 ( 3.2A)
BAT  A 559 (-2.5A)
ZN  A   1 ( 3.3A)
ZN  A   1 ( 3.3A)
0.17A15.80
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3LIL_A_HAEA302_1
(MACROPHAGE
METALLOELASTASE)		2y6c MATRILYSIN
(Homo
sapiens)		4 / 4HIS A 219
GLU A 220
HIS A 223
HIS A 229
 ZN  A1267 ( 3.2A)
TQI  A1269 (-2.9A)
ZN  A1267 ( 3.3A)
ZN  A1267 ( 3.2A)
0.18A53.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LIL_A_HAEA302_1
(MACROPHAGE
METALLOELASTASE)		3b8z PROTEIN ADAMTS-5
(Homo
sapiens)		4 / 4HIS A 410
GLU A 411
HIS A 414
HIS A 420
 ZN  A 901 ( 3.2A)
294  A 801 (-2.7A)
ZN  A 901 ( 3.3A)
ZN  A 901 ( 3.3A)
0.15A23.72
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3LIL_A_HAEA302_1
(MACROPHAGE
METALLOELASTASE)		3ba0 MACROPHAGE
METALLOELASTASE
(Homo
sapiens)		4 / 4HIS A 218
GLU A 219
HIS A 222
HIS A 228
 ZN  A 471 (-4.0A)
ZN  A 471 ( 3.2A)
HAE  A 477 ( 3.1A)
ZN  A 471 (-3.7A)
0.42A100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LIL_A_HAEA302_1
(MACROPHAGE
METALLOELASTASE)		3edi TOLLOID-LIKE PROTEIN
1
(Homo
sapiens)		4 / 4HIS A  92
GLU A  93
HIS A  96
HIS A 102
 ZN  A 210 (-3.2A)
ZN  A 210 ( 4.3A)
ZN  A 210 (-3.3A)
ZN  A 210 (-3.2A)
0.15A23.12
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3LIL_A_HAEA302_1
(MACROPHAGE
METALLOELASTASE)		3o2x COLLAGENASE 3
(Homo
sapiens)		4 / 4HIS A1222
GLU A1223
HIS A1226
HIS A1232
 ZN  A1999 ( 3.2A)
3O2  A1801 (-2.7A)
ZN  A1999 ( 3.4A)
ZN  A1999 ( 3.2A)
0.22A56.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LIL_A_HAEA302_1
(MACROPHAGE
METALLOELASTASE)		3q2h A DISINTEGRIN AND
METALLOPROTEINASE
WITH THROMBOSPONDIN
MOTIFS 1
(Homo
sapiens)		4 / 4HIS A 149
GLU A 150
HIS A 153
HIS A 159
 ZN  A 401 ( 3.3A)
QHF  A   1 (-2.6A)
QHF  A   1 ( 3.0A)
ZN  A 401 ( 3.2A)
0.21A18.87
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3LIL_A_HAEA302_1
(MACROPHAGE
METALLOELASTASE)		3shi INTERSTITIAL
COLLAGENASE
(Homo
sapiens)		4 / 4HIS A 218
GLU A 219
HIS A 222
HIS A 228
 ZN  A 301 (-3.3A)
ZN  A 301 ( 4.7A)
ZN  A 301 (-3.4A)
ZN  A 301 (-3.3A)
0.27A57.67
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3LIL_A_HAEA302_1
(MACROPHAGE
METALLOELASTASE)		3v96 STROMELYSIN-2
(Homo
sapiens)		4 / 4HIS B 217
GLU B 218
HIS B 221
HIS B 227
 ZN  B 301 (-3.2A)
ZN  B 301 ( 3.9A)
ZN  B 301 (-3.3A)
ZN  B 301 (-3.2A)
0.28A55.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LIL_A_HAEA302_1
(MACROPHAGE
METALLOELASTASE)		4dd8 DISINTEGRIN AND
METALLOPROTEINASE
DOMAIN-CONTAINING
PROTEIN 8
(Homo
sapiens)		4 / 4HIS A 334
GLU A 335
HIS A 338
HIS A 344
 ZN  A1002 ( 3.3A)
BAT  A1000 (-2.7A)
ZN  A1002 (-3.3A)
ZN  A1002 ( 3.3A)
0.41A18.52
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3LIL_A_HAEA302_1
(MACROPHAGE
METALLOELASTASE)		4gr8 MACROPHAGE
METALLOELASTASE
(Homo
sapiens)		4 / 4HIS A 218
GLU A 219
HIS A 222
HIS A 228
R4C  A 306 ( 3.2A)
R4C  A 306 (-2.7A)
ZN  A 301 ( 3.2A)
ZN  A 301 ( 3.2A)
0.19A100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LIL_A_HAEA302_1
(MACROPHAGE
METALLOELASTASE)		4gwn MEPRIN A SUBUNIT
BETA
(Homo
sapiens)		4 / 4HIS A 152
GLU A 153
HIS A 156
HIS A 162
 CD  A 701 (-3.7A)
CD  A 701 (-3.5A)
CD  A 701 (-3.7A)
CD  A 701 (-3.7A)
0.29A13.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LIL_A_HAEA302_1
(MACROPHAGE
METALLOELASTASE)		4qgn 1,2-DIHYDROXY-3-KETO
-5-METHYLTHIOPENTENE
DIOXYGENASE
(Homo
sapiens)		4 / 4HIS A 133
GLU A  94
HIS A  90
HIS A  88
 FE  A 201 (-3.3A)
FE  A 201 ( 2.7A)
FE  A 201 (-3.3A)
FE  A 201 (-3.4A)
1.06A20.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LIL_A_HAEA302_1
(MACROPHAGE
METALLOELASTASE)		4wk7 A DISINTEGRIN AND
METALLOPROTEINASE
WITH THROMBOSPONDIN
MOTIFS 4
(Homo
sapiens)		4 / 4HIS A 361
GLU A 362
HIS A 365
HIS A 371
 ZN  A 501 ( 3.2A)
3PQ  A 505 (-2.6A)
ZN  A 501 ( 3.3A)
ZN  A 501 ( 3.2A)
0.23A19.67
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3LIL_A_HAEA302_1
(MACROPHAGE
METALLOELASTASE)		4xct MATRIX
METALLOPROTEINASE-9,
MATRIX
METALLOPROTEINASE-9
(Homo
sapiens)		4 / 4HIS A 226
GLU A 227
HIS A 230
HIS A 236
 ZN  A 302 ( 3.2A)
N73  A 301 (-2.5A)
ZN  A 302 ( 3.3A)
ZN  A 302 ( 3.3A)
0.09A50.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3LIL_A_HAEA302_1
(MACROPHAGE
METALLOELASTASE)		5h0u MATRIX
METALLOPROTEINASE-14
(Homo
sapiens)		4 / 4HIS A 239
GLU A 240
HIS A 243
HIS A 249
 ZN  A 302 ( 3.3A)
GOL  A 311 (-4.2A)
ZN  A 302 (-3.4A)
ZN  A 302 (-3.2A)
0.12A50.89
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3LIL_A_HAEA302_1
(MACROPHAGE
METALLOELASTASE)		5th6 MATRIX
METALLOPROTEINASE-9,
MATRIX
METALLOPROTEINASE-9
(Homo
sapiens)		4 / 4HIS A 401
GLU A 402
HIS A 405
HIS A 411
 ZN  A 501 (-3.3A)
ZN  A 501 ( 4.2A)
ZN  A 501 (-3.2A)
ZN  A 501 (-3.1A)
0.21A35.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LIL_A_HAEA302_1
(MACROPHAGE
METALLOELASTASE)		6bdz DISINTEGRIN AND
METALLOPROTEINASE
DOMAIN-CONTAINING
PROTEIN 10
(Homo
sapiens)		4 / 4HIS A 383
GLU A 384
HIS A 387
HIS A 393
 ZN  A 705 (-3.3A)
ZN  A 705 (-3.8A)
ZN  A 705 (-4.0A)
ZN  A 705 (-3.2A)
0.48A19.87
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3LJG_A_HAEA301_1
(MACROPHAGE
METALLOELASTASE)		1hfs STROMELYSIN-1
(Homo
sapiens)		4 / 5HIS A 201
GLU A 202
HIS A 205
HIS A 211
 ZN  A 257 ( 3.1A)
L04  A 256 ( 2.7A)
ZN  A 257 ( 3.2A)
ZN  A 257 ( 3.1A)
0.21A58.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LJG_A_HAEA301_1
(MACROPHAGE
METALLOELASTASE)		1kcw CERULOPLASMIN
(Homo
sapiens)		4 / 5ILE A 159
HIS A 163
HIS A 980
HIS A1020
None
CU  A1050 (-3.3A)
CU  A1050 (-3.0A)
CU  A1050 (-3.2A)
0.98A9.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LJG_A_HAEA301_1
(MACROPHAGE
METALLOELASTASE)		1l6j MATRIX
METALLOPROTEINASE-9
(Homo
sapiens)		4 / 5HIS A 401
GLU A 402
HIS A 405
HIS A 411
 ZN  A 500 (-3.4A)
ZN  A 500 ( 4.3A)
ZN  A 500 (-3.2A)
ZN  A 500 (-3.4A)
0.25A23.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3LJG_A_HAEA301_1
(MACROPHAGE
METALLOELASTASE)		1qib 72 KDA TYPE IV
COLLAGENASE
(Homo
sapiens)		4 / 5HIS A 201
GLU A 202
HIS A 205
HIS A 211
 ZN  A 501 (-3.5A)
ZN  A 501 ( 4.5A)
ZN  A 501 (-3.5A)
ZN  A 501 (-3.5A)
0.30A59.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LJG_A_HAEA301_1
(MACROPHAGE
METALLOELASTASE)		1r55 ADAM 33
(Homo
sapiens)		4 / 5HIS A 345
GLU A 346
HIS A 349
HIS A 355
 ZN  A 201 ( 3.3A)
097  A 518 (-2.9A)
ZN  A 201 ( 3.2A)
ZN  A 201 ( 3.3A)
0.28A25.33
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3LJG_A_HAEA301_1
(MACROPHAGE
METALLOELASTASE)		1rm8 MATRIX
METALLOPROTEINASE-16
(Homo
sapiens)		4 / 5HIS A 246
GLU A 247
HIS A 250
HIS A 256
 ZN  A 500 ( 3.3A)
BAT  A 800 (-2.7A)
ZN  A 500 ( 3.2A)
ZN  A 500 ( 3.3A)
0.21A50.89
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3LJG_A_HAEA301_1
(MACROPHAGE
METALLOELASTASE)		1slm STROMELYSIN-1
(Homo
sapiens)		4 / 5HIS A 201
GLU A 202
HIS A 205
HIS A 211
 ZN  A 257 ( 3.0A)
ZN  A 257 ( 4.1A)
ZN  A 257 ( 3.2A)
ZN  A 257 ( 3.1A)
0.27A41.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LJG_A_HAEA301_1
(MACROPHAGE
METALLOELASTASE)		1xcr HYPOTHETICAL PROTEIN
PTD012
(Homo
sapiens)		4 / 5HIS A 268
GLU A 110
HIS A 278
HIS A 266
 ZN  A1001 ( 3.2A)
ACY  A2001 ( 3.7A)
ZN  A1001 ( 3.2A)
ZN  A1001 ( 3.2A)
0.93A21.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LJG_A_HAEA301_1
(MACROPHAGE
METALLOELASTASE)		2fv5 ADAM 17
(Homo
sapiens)		4 / 5HIS A 405
GLU A 406
HIS A 409
HIS A 415
 ZN  A   3 ( 3.2A)
541  A   1 (-2.6A)
ZN  A   3 ( 3.3A)
ZN  A   3 ( 3.2A)
0.26A23.08
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3LJG_A_HAEA301_1
(MACROPHAGE
METALLOELASTASE)		2jsd MATRIX
METALLOPROTEINASE-20
(Homo
sapiens)		4 / 5HIS A 226
GLU A 227
HIS A 230
HIS A 236
NGH  A 277 ( 3.0A)
NGH  A 277 (-3.6A)
ZN  A 276 ( 3.3A)
ZN  A 276 ( 3.0A)
0.64A54.09
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3LJG_A_HAEA301_1
(MACROPHAGE
METALLOELASTASE)		2oy4 NEUTROPHIL
COLLAGENASE
(Homo
sapiens)		5 / 5ILE A 159
HIS A 197
GLU A 198
HIS A 201
HIS A 207
None
ZN  A 999 (-3.2A)
ZN  A 999 ( 4.4A)
ZN  A 999 (-3.4A)
ZN  A 999 (-3.2A)
0.29A53.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LJG_A_HAEA301_1
(MACROPHAGE
METALLOELASTASE)		2rjq ADAMTS-5
(Homo
sapiens)		4 / 5HIS A 410
GLU A 411
HIS A 414
HIS A 420
 ZN  A   1 ( 3.2A)
BAT  A 559 (-2.5A)
ZN  A   1 ( 3.3A)
ZN  A   1 ( 3.3A)
0.18A15.80
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3LJG_A_HAEA301_1
(MACROPHAGE
METALLOELASTASE)		2y6c MATRILYSIN
(Homo
sapiens)		4 / 5HIS A 219
GLU A 220
HIS A 223
HIS A 229
 ZN  A1267 ( 3.2A)
TQI  A1269 (-2.9A)
ZN  A1267 ( 3.3A)
ZN  A1267 ( 3.2A)
0.20A53.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LJG_A_HAEA301_1
(MACROPHAGE
METALLOELASTASE)		3b8z PROTEIN ADAMTS-5
(Homo
sapiens)		4 / 5HIS A 410
GLU A 411
HIS A 414
HIS A 420
 ZN  A 901 ( 3.2A)
294  A 801 (-2.7A)
ZN  A 901 ( 3.3A)
ZN  A 901 ( 3.3A)
0.13A23.72
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3LJG_A_HAEA301_1
(MACROPHAGE
METALLOELASTASE)		3ba0 MACROPHAGE
METALLOELASTASE
(Homo
sapiens)		5 / 5ILE A 180
HIS A 218
GLU A 219
HIS A 222
HIS A 228
None
ZN  A 471 (-4.0A)
ZN  A 471 ( 3.2A)
HAE  A 477 ( 3.1A)
ZN  A 471 (-3.7A)
0.65A100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LJG_A_HAEA301_1
(MACROPHAGE
METALLOELASTASE)		3edi TOLLOID-LIKE PROTEIN
1
(Homo
sapiens)		4 / 5HIS A  92
GLU A  93
HIS A  96
HIS A 102
 ZN  A 210 (-3.2A)
ZN  A 210 ( 4.3A)
ZN  A 210 (-3.3A)
ZN  A 210 (-3.2A)
0.19A23.12
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3LJG_A_HAEA301_1
(MACROPHAGE
METALLOELASTASE)		3o2x COLLAGENASE 3
(Homo
sapiens)		4 / 5HIS A1222
GLU A1223
HIS A1226
HIS A1232
 ZN  A1999 ( 3.2A)
3O2  A1801 (-2.7A)
ZN  A1999 ( 3.4A)
ZN  A1999 ( 3.2A)
0.26A56.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LJG_A_HAEA301_1
(MACROPHAGE
METALLOELASTASE)		3q2h A DISINTEGRIN AND
METALLOPROTEINASE
WITH THROMBOSPONDIN
MOTIFS 1
(Homo
sapiens)		4 / 5HIS A 149
GLU A 150
HIS A 153
HIS A 159
 ZN  A 401 ( 3.3A)
QHF  A   1 (-2.6A)
QHF  A   1 ( 3.0A)
ZN  A 401 ( 3.2A)
0.21A18.87
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3LJG_A_HAEA301_1
(MACROPHAGE
METALLOELASTASE)		3shi INTERSTITIAL
COLLAGENASE
(Homo
sapiens)		4 / 5HIS A 218
GLU A 219
HIS A 222
HIS A 228
 ZN  A 301 (-3.3A)
ZN  A 301 ( 4.7A)
ZN  A 301 (-3.4A)
ZN  A 301 (-3.3A)
0.26A57.67
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3LJG_A_HAEA301_1
(MACROPHAGE
METALLOELASTASE)		3v96 STROMELYSIN-2
(Homo
sapiens)		4 / 5HIS B 217
GLU B 218
HIS B 221
HIS B 227
 ZN  B 301 (-3.2A)
ZN  B 301 ( 3.9A)
ZN  B 301 (-3.3A)
ZN  B 301 (-3.2A)
0.32A55.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LJG_A_HAEA301_1
(MACROPHAGE
METALLOELASTASE)		4dd8 DISINTEGRIN AND
METALLOPROTEINASE
DOMAIN-CONTAINING
PROTEIN 8
(Homo
sapiens)		4 / 5HIS A 334
GLU A 335
HIS A 338
HIS A 344
 ZN  A1002 ( 3.3A)
BAT  A1000 (-2.7A)
ZN  A1002 (-3.3A)
ZN  A1002 ( 3.3A)
0.41A18.52
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3LJG_A_HAEA301_1
(MACROPHAGE
METALLOELASTASE)		4gr8 MACROPHAGE
METALLOELASTASE
(Homo
sapiens)		5 / 5ILE A 180
HIS A 218
GLU A 219
HIS A 222
HIS A 228
R4C  A 306 (-4.3A)
R4C  A 306 ( 3.2A)
R4C  A 306 (-2.7A)
ZN  A 301 ( 3.2A)
ZN  A 301 ( 3.2A)
0.44A100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LJG_A_HAEA301_1
(MACROPHAGE
METALLOELASTASE)		4gwn MEPRIN A SUBUNIT
BETA
(Homo
sapiens)		4 / 5HIS A 152
GLU A 153
HIS A 156
HIS A 162
 CD  A 701 (-3.7A)
CD  A 701 (-3.5A)
CD  A 701 (-3.7A)
CD  A 701 (-3.7A)
0.32A13.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LJG_A_HAEA301_1
(MACROPHAGE
METALLOELASTASE)		4wk7 A DISINTEGRIN AND
METALLOPROTEINASE
WITH THROMBOSPONDIN
MOTIFS 4
(Homo
sapiens)		4 / 5HIS A 361
GLU A 362
HIS A 365
HIS A 371
 ZN  A 501 ( 3.2A)
3PQ  A 505 (-2.6A)
ZN  A 501 ( 3.3A)
ZN  A 501 ( 3.2A)
0.22A19.67
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3LJG_A_HAEA301_1
(MACROPHAGE
METALLOELASTASE)		4xct MATRIX
METALLOPROTEINASE-9,
MATRIX
METALLOPROTEINASE-9
(Homo
sapiens)		4 / 5HIS A 226
GLU A 227
HIS A 230
HIS A 236
 ZN  A 302 ( 3.2A)
N73  A 301 (-2.5A)
ZN  A 302 ( 3.3A)
ZN  A 302 ( 3.3A)
0.14A50.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3LJG_A_HAEA301_1
(MACROPHAGE
METALLOELASTASE)		5h0u MATRIX
METALLOPROTEINASE-14
(Homo
sapiens)		4 / 5HIS A 239
GLU A 240
HIS A 243
HIS A 249
 ZN  A 302 ( 3.3A)
GOL  A 311 (-4.2A)
ZN  A 302 (-3.4A)
ZN  A 302 (-3.2A)
0.16A50.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LJG_A_HAEA301_1
(MACROPHAGE
METALLOELASTASE)		5lxg ADIPONECTIN RECEPTOR
PROTEIN 1
(Homo
sapiens)		4 / 5ILE A 212
HIS A 341
HIS A 337
HIS A 191
None
ZN  A 401 (-3.2A)
ZN  A 401 (-3.5A)
ZN  A 401 (-3.5A)
1.01A16.72
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3LJG_A_HAEA301_1
(MACROPHAGE
METALLOELASTASE)		5th6 MATRIX
METALLOPROTEINASE-9,
MATRIX
METALLOPROTEINASE-9
(Homo
sapiens)		4 / 5HIS A 401
GLU A 402
HIS A 405
HIS A 411
 ZN  A 501 (-3.3A)
ZN  A 501 ( 4.2A)
ZN  A 501 (-3.2A)
ZN  A 501 (-3.1A)
0.23A35.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LJG_A_HAEA301_1
(MACROPHAGE
METALLOELASTASE)		6bdz DISINTEGRIN AND
METALLOPROTEINASE
DOMAIN-CONTAINING
PROTEIN 10
(Homo
sapiens)		4 / 5HIS A 383
GLU A 384
HIS A 387
HIS A 393
 ZN  A 705 (-3.3A)
ZN  A 705 (-3.8A)
ZN  A 705 (-4.0A)
ZN  A 705 (-3.2A)
0.51A19.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LKA_A_HAEA269_1
(MACROPHAGE
METALLOELASTASE)		1ck7 PROTEIN (GELATINASE
A)
(Homo
sapiens)		4 / 5HIS A 193
HIS A 403
HIS A 407
HIS A 413
 ZN  A 991 ( 3.1A)
ZN  A 990 ( 3.4A)
ZN  A 990 ( 3.3A)
ZN  A 990 ( 3.4A)
0.46A23.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LKA_A_HAEA269_1
(MACROPHAGE
METALLOELASTASE)		1eak 72 KDA TYPE IV
COLLAGENASE
(Homo
sapiens)		4 / 5HIS A 193
HIS A 403
HIS A 407
HIS A 413
 ZN  A 996 (-3.1A)
ZN  A 997 (-3.5A)
ZN  A 997 (-3.6A)
ZN  A 997 (-3.5A)
0.42A23.74
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3LKA_A_HAEA269_1
(MACROPHAGE
METALLOELASTASE)		1hfs STROMELYSIN-1
(Homo
sapiens)		5 / 5HIS A 166
HIS A 201
GLU A 202
HIS A 205
HIS A 211
 ZN  A 258 ( 3.0A)
ZN  A 257 ( 3.1A)
L04  A 256 ( 2.7A)
ZN  A 257 ( 3.2A)
ZN  A 257 ( 3.1A)
0.55A59.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LKA_A_HAEA269_1
(MACROPHAGE
METALLOELASTASE)		1l6j MATRIX
METALLOPROTEINASE-9
(Homo
sapiens)		5 / 5HIS A 190
HIS A 401
GLU A 402
HIS A 405
HIS A 411
 ZN  A 501 (-3.4A)
ZN  A 500 (-3.4A)
ZN  A 500 ( 4.3A)
ZN  A 500 (-3.2A)
ZN  A 500 (-3.4A)
0.34A23.22
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3LKA_A_HAEA269_1
(MACROPHAGE
METALLOELASTASE)		1qib 72 KDA TYPE IV
COLLAGENASE
(Homo
sapiens)		5 / 5HIS A 166
HIS A 201
GLU A 202
HIS A 205
HIS A 211
 ZN  A 502 (-3.5A)
ZN  A 501 (-3.5A)
ZN  A 501 ( 4.5A)
ZN  A 501 (-3.5A)
ZN  A 501 (-3.5A)
0.35A59.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LKA_A_HAEA269_1
(MACROPHAGE
METALLOELASTASE)		1r55 ADAM 33
(Homo
sapiens)		4 / 5HIS A 345
GLU A 346
HIS A 349
HIS A 355
 ZN  A 201 ( 3.3A)
097  A 518 (-2.9A)
ZN  A 201 ( 3.2A)
ZN  A 201 ( 3.3A)
0.26A25.33
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3LKA_A_HAEA269_1
(MACROPHAGE
METALLOELASTASE)		1rm8 MATRIX
METALLOPROTEINASE-16
(Homo
sapiens)		5 / 5HIS A 208
HIS A 246
GLU A 247
HIS A 250
HIS A 256
 ZN  A 501 (-3.2A)
ZN  A 500 ( 3.3A)
BAT  A 800 (-2.7A)
ZN  A 500 ( 3.2A)
ZN  A 500 ( 3.3A)
0.25A51.19
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3LKA_A_HAEA269_1
(MACROPHAGE
METALLOELASTASE)		1slm STROMELYSIN-1
(Homo
sapiens)		5 / 5HIS A 166
HIS A 201
GLU A 202
HIS A 205
HIS A 211
 ZN  A 258 ( 3.0A)
ZN  A 257 ( 3.0A)
ZN  A 257 ( 4.1A)
ZN  A 257 ( 3.2A)
ZN  A 257 ( 3.1A)
0.31A46.38
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3LKA_A_HAEA269_1
(MACROPHAGE
METALLOELASTASE)		1su3 INTERSTITIAL
COLLAGENASE
(Homo
sapiens)		4 / 5HIS A 183
HIS A 218
HIS A 222
HIS A 228
 ZN  A 915 (-3.3A)
ZN  A 913 (-3.2A)
ZN  A 913 (-3.2A)
ZN  A 913 (-3.2A)
0.27A45.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LKA_A_HAEA269_1
(MACROPHAGE
METALLOELASTASE)		1xcr HYPOTHETICAL PROTEIN
PTD012
(Homo
sapiens)		4 / 5HIS A 268
GLU A 110
HIS A 278
HIS A 266
 ZN  A1001 ( 3.2A)
ACY  A2001 ( 3.7A)
ZN  A1001 ( 3.2A)
ZN  A1001 ( 3.2A)
0.95A19.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LKA_A_HAEA269_1
(MACROPHAGE
METALLOELASTASE)		2fv5 ADAM 17
(Homo
sapiens)		4 / 5HIS A 405
GLU A 406
HIS A 409
HIS A 415
 ZN  A   3 ( 3.2A)
541  A   1 (-2.6A)
ZN  A   3 ( 3.3A)
ZN  A   3 ( 3.2A)
0.24A23.08
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3LKA_A_HAEA269_1
(MACROPHAGE
METALLOELASTASE)		2jsd MATRIX
METALLOPROTEINASE-20
(Homo
sapiens)		5 / 5HIS A 191
HIS A 226
GLU A 227
HIS A 230
HIS A 236
 ZN  A 275 (-3.4A)
NGH  A 277 ( 3.0A)
NGH  A 277 (-3.6A)
ZN  A 276 ( 3.3A)
ZN  A 276 ( 3.0A)
0.74A54.72
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3LKA_A_HAEA269_1
(MACROPHAGE
METALLOELASTASE)		2oy4 NEUTROPHIL
COLLAGENASE
(Homo
sapiens)		5 / 5HIS A 162
HIS A 197
GLU A 198
HIS A 201
HIS A 207
 ZN  A 998 (-3.3A)
ZN  A 999 (-3.2A)
ZN  A 999 ( 4.4A)
ZN  A 999 (-3.4A)
ZN  A 999 (-3.2A)
0.27A53.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LKA_A_HAEA269_1
(MACROPHAGE
METALLOELASTASE)		2rjq ADAMTS-5
(Homo
sapiens)		4 / 5HIS A 410
GLU A 411
HIS A 414
HIS A 420
 ZN  A   1 ( 3.2A)
BAT  A 559 (-2.5A)
ZN  A   1 ( 3.3A)
ZN  A   1 ( 3.3A)
0.17A16.08
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3LKA_A_HAEA269_1
(MACROPHAGE
METALLOELASTASE)		2y6c MATRILYSIN
(Homo
sapiens)		5 / 5HIS A 183
HIS A 219
GLU A 220
HIS A 223
HIS A 229
 ZN  A1266 ( 3.3A)
ZN  A1267 ( 3.2A)
TQI  A1269 (-2.9A)
ZN  A1267 ( 3.3A)
ZN  A1267 ( 3.2A)
0.41A54.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LKA_A_HAEA269_1
(MACROPHAGE
METALLOELASTASE)		3b8z PROTEIN ADAMTS-5
(Homo
sapiens)		4 / 5HIS A 410
GLU A 411
HIS A 414
HIS A 420
 ZN  A 901 ( 3.2A)
294  A 801 (-2.7A)
ZN  A 901 ( 3.3A)
ZN  A 901 ( 3.3A)
0.17A23.72
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3LKA_A_HAEA269_1
(MACROPHAGE
METALLOELASTASE)		3ba0 MACROPHAGE
METALLOELASTASE
(Homo
sapiens)		5 / 5HIS A 183
HIS A 218
GLU A 219
HIS A 222
HIS A 228
 ZN  A 472 (-3.1A)
ZN  A 471 (-4.0A)
ZN  A 471 ( 3.2A)
HAE  A 477 ( 3.1A)
ZN  A 471 (-3.7A)
0.68A100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LKA_A_HAEA269_1
(MACROPHAGE
METALLOELASTASE)		3edi TOLLOID-LIKE PROTEIN
1
(Homo
sapiens)		4 / 5HIS A  92
GLU A  93
HIS A  96
HIS A 102
 ZN  A 210 (-3.2A)
ZN  A 210 ( 4.3A)
ZN  A 210 (-3.3A)
ZN  A 210 (-3.2A)
0.17A24.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LKA_A_HAEA269_1
(MACROPHAGE
METALLOELASTASE)		3hig AMILORIDE-SENSITIVE
AMINE OXIDASE
(Homo
sapiens)		4 / 5HIS A 486
HIS A 512
HIS A 510
HIS A 675
None
CU  A 801 (-3.2A)
CU  A 801 (-3.3A)
CU  A 801 (-3.0A)
1.00A11.76
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3LKA_A_HAEA269_1
(MACROPHAGE
METALLOELASTASE)		3o2x COLLAGENASE 3
(Homo
sapiens)		5 / 5HIS A1187
HIS A1222
GLU A1223
HIS A1226
HIS A1232
 ZN  A1998 ( 3.2A)
ZN  A1999 ( 3.2A)
3O2  A1801 (-2.7A)
ZN  A1999 ( 3.4A)
ZN  A1999 ( 3.2A)
0.39A56.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LKA_A_HAEA269_1
(MACROPHAGE
METALLOELASTASE)		3q2h A DISINTEGRIN AND
METALLOPROTEINASE
WITH THROMBOSPONDIN
MOTIFS 1
(Homo
sapiens)		4 / 5HIS A 149
GLU A 150
HIS A 153
HIS A 159
 ZN  A 401 ( 3.3A)
QHF  A   1 (-2.6A)
QHF  A   1 ( 3.0A)
ZN  A 401 ( 3.2A)
0.16A18.87
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3LKA_A_HAEA269_1
(MACROPHAGE
METALLOELASTASE)		3shi INTERSTITIAL
COLLAGENASE
(Homo
sapiens)		5 / 5HIS A 183
HIS A 218
GLU A 219
HIS A 222
HIS A 228
 ZN  A 302 (-3.1A)
ZN  A 301 (-3.3A)
ZN  A 301 ( 4.7A)
ZN  A 301 (-3.4A)
ZN  A 301 (-3.3A)
0.38A58.02
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3LKA_A_HAEA269_1
(MACROPHAGE
METALLOELASTASE)		3v96 STROMELYSIN-2
(Homo
sapiens)		5 / 5HIS B 182
HIS B 217
GLU B 218
HIS B 221
HIS B 227
 ZN  B 302 (-3.2A)
ZN  B 301 (-3.2A)
ZN  B 301 ( 3.9A)
ZN  B 301 (-3.3A)
ZN  B 301 (-3.2A)
0.36A57.50
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3LKA_A_HAEA269_1
(MACROPHAGE
METALLOELASTASE)		4auo INTERSTITIAL
COLLAGENASE
(Homo
sapiens)		4 / 5HIS A 164
HIS A 199
HIS A 203
HIS A 209
 ZN  A1201 (-3.1A)
ZN  A1202 (-3.0A)
ZN  A1202 (-3.1A)
ZN  A1202 (-3.4A)
0.25A57.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LKA_A_HAEA269_1
(MACROPHAGE
METALLOELASTASE)		4dd8 DISINTEGRIN AND
METALLOPROTEINASE
DOMAIN-CONTAINING
PROTEIN 8
(Homo
sapiens)		4 / 5HIS A 334
GLU A 335
HIS A 338
HIS A 344
 ZN  A1002 ( 3.3A)
BAT  A1000 (-2.7A)
ZN  A1002 (-3.3A)
ZN  A1002 ( 3.3A)
0.37A19.91
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3LKA_A_HAEA269_1
(MACROPHAGE
METALLOELASTASE)		4fvl COLLAGENASE 3
(Homo
sapiens)		4 / 5HIS A 187
HIS A 222
HIS A 226
HIS A 232
 ZN  A 502 (-3.3A)
ZN  A 501 (-3.3A)
ZN  A 501 (-3.1A)
ZN  A 501 (-3.2A)
0.47A55.49
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3LKA_A_HAEA269_1
(MACROPHAGE
METALLOELASTASE)		4gr8 MACROPHAGE
METALLOELASTASE
(Homo
sapiens)		5 / 5HIS A 183
HIS A 218
GLU A 219
HIS A 222
HIS A 228
 ZN  A 302 (-3.2A)
R4C  A 306 ( 3.2A)
R4C  A 306 (-2.7A)
ZN  A 301 ( 3.2A)
ZN  A 301 ( 3.2A)
0.40A100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LKA_A_HAEA269_1
(MACROPHAGE
METALLOELASTASE)		4gwn MEPRIN A SUBUNIT
BETA
(Homo
sapiens)		4 / 5HIS A 152
GLU A 153
HIS A 156
HIS A 162
 CD  A 701 (-3.7A)
CD  A 701 (-3.5A)
CD  A 701 (-3.7A)
CD  A 701 (-3.7A)
0.27A14.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LKA_A_HAEA269_1
(MACROPHAGE
METALLOELASTASE)		4qgn 1,2-DIHYDROXY-3-KETO
-5-METHYLTHIOPENTENE
DIOXYGENASE
(Homo
sapiens)		4 / 5HIS A 133
GLU A  94
HIS A  90
HIS A  88
 FE  A 201 (-3.3A)
FE  A 201 ( 2.7A)
FE  A 201 (-3.3A)
FE  A 201 (-3.4A)
1.02A20.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LKA_A_HAEA269_1
(MACROPHAGE
METALLOELASTASE)		4wk7 A DISINTEGRIN AND
METALLOPROTEINASE
WITH THROMBOSPONDIN
MOTIFS 4
(Homo
sapiens)		4 / 5HIS A 361
GLU A 362
HIS A 365
HIS A 371
 ZN  A 501 ( 3.2A)
3PQ  A 505 (-2.6A)
ZN  A 501 ( 3.3A)
ZN  A 501 ( 3.2A)
0.25A19.67
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3LKA_A_HAEA269_1
(MACROPHAGE
METALLOELASTASE)		4xct MATRIX
METALLOPROTEINASE-9,
MATRIX
METALLOPROTEINASE-9
(Homo
sapiens)		5 / 5HIS A 190
HIS A 226
GLU A 227
HIS A 230
HIS A 236
 ZN  A 303 ( 3.2A)
ZN  A 302 ( 3.2A)
N73  A 301 (-2.5A)
ZN  A 302 ( 3.3A)
ZN  A 302 ( 3.3A)
0.27A50.31
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3LKA_A_HAEA269_1
(MACROPHAGE
METALLOELASTASE)		5h0u MATRIX
METALLOPROTEINASE-14
(Homo
sapiens)		5 / 5HIS A 201
HIS A 239
GLU A 240
HIS A 243
HIS A 249
 ZN  A 303 (-3.2A)
ZN  A 302 ( 3.3A)
GOL  A 311 (-4.2A)
ZN  A 302 (-3.4A)
ZN  A 302 (-3.2A)
0.40A50.89
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3LKA_A_HAEA269_1
(MACROPHAGE
METALLOELASTASE)		5th6 MATRIX
METALLOPROTEINASE-9,
MATRIX
METALLOPROTEINASE-9
(Homo
sapiens)		5 / 5HIS A 190
HIS A 401
GLU A 402
HIS A 405
HIS A 411
 ZN  A 502 (-3.2A)
ZN  A 501 (-3.3A)
ZN  A 501 ( 4.2A)
ZN  A 501 (-3.2A)
ZN  A 501 (-3.1A)
0.29A40.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LKA_A_HAEA269_1
(MACROPHAGE
METALLOELASTASE)		6bdz DISINTEGRIN AND
METALLOPROTEINASE
DOMAIN-CONTAINING
PROTEIN 10
(Homo
sapiens)		4 / 5HIS A 383
GLU A 384
HIS A 387
HIS A 393
 ZN  A 705 (-3.3A)
ZN  A 705 (-3.8A)
ZN  A 705 (-4.0A)
ZN  A 705 (-3.2A)
0.45A20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A7B_A_HAEA1273_1
(COLLAGENASE 3)		1ck7 PROTEIN (GELATINASE
A)
(Homo
sapiens)		4 / 6HIS A 193
HIS A 403
HIS A 407
HIS A 413
 ZN  A 991 ( 3.1A)
ZN  A 990 ( 3.4A)
ZN  A 990 ( 3.3A)
ZN  A 990 ( 3.4A)
0.40A23.58
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4A7B_A_HAEA1273_1
(COLLAGENASE 3)		1eak 72 KDA TYPE IV
COLLAGENASE
(Homo
sapiens)		4 / 6HIS A 193
HIS A 403
HIS A 407
HIS A 413
 ZN  A 996 (-3.1A)
ZN  A 997 (-3.5A)
ZN  A 997 (-3.6A)
ZN  A 997 (-3.5A)
0.35A32.75
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4A7B_A_HAEA1273_1
(COLLAGENASE 3)		1hfs STROMELYSIN-1
(Homo
sapiens)		5 / 6HIS A 166
HIS A 201
GLU A 202
HIS A 205
HIS A 211
 ZN  A 258 ( 3.0A)
ZN  A 257 ( 3.1A)
L04  A 256 ( 2.7A)
ZN  A 257 ( 3.2A)
ZN  A 257 ( 3.1A)
0.63A61.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A7B_A_HAEA1273_1
(COLLAGENASE 3)		1l6j MATRIX
METALLOPROTEINASE-9
(Homo
sapiens)		5 / 6HIS A 190
HIS A 401
GLU A 402
HIS A 405
HIS A 411
 ZN  A 501 (-3.4A)
ZN  A 500 (-3.4A)
ZN  A 500 ( 4.3A)
ZN  A 500 (-3.2A)
ZN  A 500 (-3.4A)
0.32A24.12
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4A7B_A_HAEA1273_1
(COLLAGENASE 3)		1qib 72 KDA TYPE IV
COLLAGENASE
(Homo
sapiens)		5 / 6HIS A 166
HIS A 201
GLU A 202
HIS A 205
HIS A 211
 ZN  A 502 (-3.5A)
ZN  A 501 (-3.5A)
ZN  A 501 ( 4.5A)
ZN  A 501 (-3.5A)
ZN  A 501 (-3.5A)
0.41A65.24
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4A7B_A_HAEA1273_1
(COLLAGENASE 3)		1qib 72 KDA TYPE IV
COLLAGENASE
(Homo
sapiens)		5 / 6LEU A 163
HIS A 166
HIS A 201
HIS A 205
HIS A 211
None
ZN  A 502 (-3.5A)
ZN  A 501 (-3.5A)
ZN  A 501 (-3.5A)
ZN  A 501 (-3.5A)
0.75A65.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A7B_A_HAEA1273_1
(COLLAGENASE 3)		1r55 ADAM 33
(Homo
sapiens)		4 / 6HIS A 345
GLU A 346
HIS A 349
HIS A 355
 ZN  A 201 ( 3.3A)
097  A 518 (-2.9A)
ZN  A 201 ( 3.2A)
ZN  A 201 ( 3.3A)
0.47A24.88
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4A7B_A_HAEA1273_1
(COLLAGENASE 3)		1rm8 MATRIX
METALLOPROTEINASE-16
(Homo
sapiens)		5 / 6HIS A 208
HIS A 246
GLU A 247
HIS A 250
HIS A 256
 ZN  A 501 (-3.2A)
ZN  A 500 ( 3.3A)
BAT  A 800 (-2.7A)
ZN  A 500 ( 3.2A)
ZN  A 500 ( 3.3A)
0.32A48.57
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4A7B_A_HAEA1273_1
(COLLAGENASE 3)		1slm STROMELYSIN-1
(Homo
sapiens)		5 / 6HIS A 166
HIS A 201
GLU A 202
HIS A 205
HIS A 211
 ZN  A 258 ( 3.0A)
ZN  A 257 ( 3.0A)
ZN  A 257 ( 4.1A)
ZN  A 257 ( 3.2A)
ZN  A 257 ( 3.1A)
0.32A43.14
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4A7B_A_HAEA1273_1
(COLLAGENASE 3)		1su3 INTERSTITIAL
COLLAGENASE
(Homo
sapiens)		4 / 6HIS A 183
HIS A 218
HIS A 222
HIS A 228
 ZN  A 915 (-3.3A)
ZN  A 913 (-3.2A)
ZN  A 913 (-3.2A)
ZN  A 913 (-3.2A)
0.36A30.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A7B_A_HAEA1273_1
(COLLAGENASE 3)		1xcr HYPOTHETICAL PROTEIN
PTD012
(Homo
sapiens)		5 / 6LEU A  68
HIS A 268
GLU A 110
HIS A 278
HIS A 266
None
ZN  A1001 ( 3.2A)
ACY  A2001 ( 3.7A)
ZN  A1001 ( 3.2A)
ZN  A1001 ( 3.2A)
1.19A18.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A7B_A_HAEA1273_1
(COLLAGENASE 3)		2fv5 ADAM 17
(Homo
sapiens)		4 / 6HIS A 405
GLU A 406
HIS A 409
HIS A 415
 ZN  A   3 ( 3.2A)
541  A   1 (-2.6A)
ZN  A   3 ( 3.3A)
ZN  A   3 ( 3.2A)
0.41A23.64
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4A7B_A_HAEA1273_1
(COLLAGENASE 3)		2jsd MATRIX
METALLOPROTEINASE-20
(Homo
sapiens)		5 / 6HIS A 191
HIS A 226
GLU A 227
HIS A 230
HIS A 236
 ZN  A 275 (-3.4A)
NGH  A 277 ( 3.0A)
NGH  A 277 (-3.6A)
ZN  A 276 ( 3.3A)
ZN  A 276 ( 3.0A)
0.66A58.18
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4A7B_A_HAEA1273_1
(COLLAGENASE 3)		2oy4 NEUTROPHIL
COLLAGENASE
(Homo
sapiens)		5 / 6HIS A 162
HIS A 197
GLU A 198
HIS A 201
HIS A 207
 ZN  A 998 (-3.3A)
ZN  A 999 (-3.2A)
ZN  A 999 ( 4.4A)
ZN  A 999 (-3.4A)
ZN  A 999 (-3.2A)
0.33A60.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A7B_A_HAEA1273_1
(COLLAGENASE 3)		2rjq ADAMTS-5
(Homo
sapiens)		4 / 6HIS A 410
GLU A 411
HIS A 414
HIS A 420
 ZN  A   1 ( 3.2A)
BAT  A 559 (-2.5A)
ZN  A   1 ( 3.3A)
ZN  A   1 ( 3.3A)
0.29A18.42
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4A7B_A_HAEA1273_1
(COLLAGENASE 3)		2y6c MATRILYSIN
(Homo
sapiens)		5 / 6HIS A 183
HIS A 219
GLU A 220
HIS A 223
HIS A 229
 ZN  A1266 ( 3.3A)
ZN  A1267 ( 3.2A)
TQI  A1269 (-2.9A)
ZN  A1267 ( 3.3A)
ZN  A1267 ( 3.2A)
0.46A52.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A7B_A_HAEA1273_1
(COLLAGENASE 3)		3b8z PROTEIN ADAMTS-5
(Homo
sapiens)		4 / 6HIS A 410
GLU A 411
HIS A 414
HIS A 420
 ZN  A 901 ( 3.2A)
294  A 801 (-2.7A)
ZN  A 901 ( 3.3A)
ZN  A 901 ( 3.3A)
0.30A23.68
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4A7B_A_HAEA1273_1
(COLLAGENASE 3)		3ba0 MACROPHAGE
METALLOELASTASE
(Homo
sapiens)		5 / 6HIS A 183
HIS A 218
GLU A 219
HIS A 222
HIS A 228
 ZN  A 472 (-3.1A)
ZN  A 471 (-4.0A)
ZN  A 471 ( 3.2A)
HAE  A 477 ( 3.1A)
ZN  A 471 (-3.7A)
0.65A31.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A7B_A_HAEA1273_1
(COLLAGENASE 3)		3e0l GUANINE DEAMINASE
(Homo
sapiens)		4 / 6LEU A 306
HIS A  82
HIS A  84
HIS A 238
None
ZN  A1452 (-3.3A)
ZN  A1452 (-3.1A)
ZN  A1452 (-3.2A)
0.92A17.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A7B_A_HAEA1273_1
(COLLAGENASE 3)		3edi TOLLOID-LIKE PROTEIN
1
(Homo
sapiens)		4 / 6HIS A  92
GLU A  93
HIS A  96
HIS A 102
 ZN  A 210 (-3.2A)
ZN  A 210 ( 4.3A)
ZN  A 210 (-3.3A)
ZN  A 210 (-3.2A)
0.18A23.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A7B_A_HAEA1273_1
(COLLAGENASE 3)		3lgg ADENOSINE DEAMINASE
CECR1
(Homo
sapiens)		4 / 6LEU A 389
HIS A  86
HIS A  88
HIS A 330
None
ZN  A 512 (-3.4A)
CFE  A 513 ( 3.3A)
ZN  A 512 ( 3.5A)
0.91A14.57
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4A7B_A_HAEA1273_1
(COLLAGENASE 3)		3o2x COLLAGENASE 3
(Homo
sapiens)		5 / 6HIS A1187
HIS A1222
GLU A1223
HIS A1226
HIS A1232
 ZN  A1998 ( 3.2A)
ZN  A1999 ( 3.2A)
3O2  A1801 (-2.7A)
ZN  A1999 ( 3.4A)
ZN  A1999 ( 3.2A)
0.36A99.39
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4A7B_A_HAEA1273_1
(COLLAGENASE 3)		3o2x COLLAGENASE 3
(Homo
sapiens)		4 / 6LEU A1184
HIS A1187
HIS A1222
HIS A1232
3O2  A1801 ( 4.5A)
ZN  A1998 ( 3.2A)
ZN  A1999 ( 3.2A)
ZN  A1999 ( 3.2A)
0.83A99.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A7B_A_HAEA1273_1
(COLLAGENASE 3)		3q2h A DISINTEGRIN AND
METALLOPROTEINASE
WITH THROMBOSPONDIN
MOTIFS 1
(Homo
sapiens)		4 / 6HIS A 149
GLU A 150
HIS A 153
HIS A 159
 ZN  A 401 ( 3.3A)
QHF  A   1 (-2.6A)
QHF  A   1 ( 3.0A)
ZN  A 401 ( 3.2A)
0.31A20.54
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4A7B_A_HAEA1273_1
(COLLAGENASE 3)		3shi INTERSTITIAL
COLLAGENASE
(Homo
sapiens)		5 / 6HIS A 183
HIS A 218
GLU A 219
HIS A 222
HIS A 228
 ZN  A 302 (-3.1A)
ZN  A 301 (-3.3A)
ZN  A 301 ( 4.7A)
ZN  A 301 (-3.4A)
ZN  A 301 (-3.3A)
0.48A58.28
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4A7B_A_HAEA1273_1
(COLLAGENASE 3)		3v96 STROMELYSIN-2
(Homo
sapiens)		5 / 6HIS B 182
HIS B 217
GLU B 218
HIS B 221
HIS B 227
 ZN  B 302 (-3.2A)
ZN  B 301 (-3.2A)
ZN  B 301 ( 3.9A)
ZN  B 301 (-3.3A)
ZN  B 301 (-3.2A)
0.35A62.42
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4A7B_A_HAEA1273_1
(COLLAGENASE 3)		4auo INTERSTITIAL
COLLAGENASE
(Homo
sapiens)		4 / 6HIS A 164
HIS A 199
HIS A 203
HIS A 209
 ZN  A1201 (-3.1A)
ZN  A1202 (-3.0A)
ZN  A1202 (-3.1A)
ZN  A1202 (-3.4A)
0.35A33.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A7B_A_HAEA1273_1
(COLLAGENASE 3)		4dd8 DISINTEGRIN AND
METALLOPROTEINASE
DOMAIN-CONTAINING
PROTEIN 8
(Homo
sapiens)		4 / 6HIS A 334
GLU A 335
HIS A 338
HIS A 344
 ZN  A1002 ( 3.3A)
BAT  A1000 (-2.7A)
ZN  A1002 (-3.3A)
ZN  A1002 ( 3.3A)
0.43A21.82
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4A7B_A_HAEA1273_1
(COLLAGENASE 3)		4fvl COLLAGENASE 3
(Homo
sapiens)		4 / 6HIS A 187
HIS A 222
HIS A 226
HIS A 232
 ZN  A 502 (-3.3A)
ZN  A 501 (-3.3A)
ZN  A 501 (-3.1A)
ZN  A 501 (-3.2A)
0.46A99.41
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4A7B_A_HAEA1273_1
(COLLAGENASE 3)		4fvl COLLAGENASE 3
(Homo
sapiens)		4 / 6LEU A 184
HIS A 187
HIS A 222
HIS A 232
None
ZN  A 502 (-3.3A)
ZN  A 501 (-3.3A)
ZN  A 501 (-3.2A)
0.86A99.41
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4A7B_A_HAEA1273_1
(COLLAGENASE 3)		4gr8 MACROPHAGE
METALLOELASTASE
(Homo
sapiens)		5 / 6HIS A 183
HIS A 218
GLU A 219
HIS A 222
HIS A 228
 ZN  A 302 (-3.2A)
R4C  A 306 ( 3.2A)
R4C  A 306 (-2.7A)
ZN  A 301 ( 3.2A)
ZN  A 301 ( 3.2A)
0.50A58.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A7B_A_HAEA1273_1
(COLLAGENASE 3)		4gwn MEPRIN A SUBUNIT
BETA
(Homo
sapiens)		4 / 6HIS A 152
GLU A 153
HIS A 156
HIS A 162
 CD  A 701 (-3.7A)
CD  A 701 (-3.5A)
CD  A 701 (-3.7A)
CD  A 701 (-3.7A)
0.22A16.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A7B_A_HAEA1273_1
(COLLAGENASE 3)		4wk7 A DISINTEGRIN AND
METALLOPROTEINASE
WITH THROMBOSPONDIN
MOTIFS 4
(Homo
sapiens)		4 / 6HIS A 361
GLU A 362
HIS A 365
HIS A 371
 ZN  A 501 ( 3.2A)
3PQ  A 505 (-2.6A)
ZN  A 501 ( 3.3A)
ZN  A 501 ( 3.2A)
0.41A24.90
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4A7B_A_HAEA1273_1
(COLLAGENASE 3)		4xct MATRIX
METALLOPROTEINASE-9,
MATRIX
METALLOPROTEINASE-9
(Homo
sapiens)		5 / 6HIS A 190
HIS A 226
GLU A 227
HIS A 230
HIS A 236
 ZN  A 303 ( 3.2A)
ZN  A 302 ( 3.2A)
N73  A 301 (-2.5A)
ZN  A 302 ( 3.3A)
ZN  A 302 ( 3.3A)
0.35A57.83
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4A7B_A_HAEA1273_1
(COLLAGENASE 3)		4xct MATRIX
METALLOPROTEINASE-9,
MATRIX
METALLOPROTEINASE-9
(Homo
sapiens)		5 / 6LEU A 187
HIS A 190
HIS A 226
HIS A 230
HIS A 236
N73  A 301 (-4.0A)
ZN  A 303 ( 3.2A)
ZN  A 302 ( 3.2A)
ZN  A 302 ( 3.3A)
ZN  A 302 ( 3.3A)
0.78A57.83
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4A7B_A_HAEA1273_1
(COLLAGENASE 3)		5h0u MATRIX
METALLOPROTEINASE-14
(Homo
sapiens)		5 / 6HIS A 201
HIS A 239
GLU A 240
HIS A 243
HIS A 249
 ZN  A 303 (-3.2A)
ZN  A 302 ( 3.3A)
GOL  A 311 (-4.2A)
ZN  A 302 (-3.4A)
ZN  A 302 (-3.2A)
0.44A48.02
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4A7B_A_HAEA1273_1
(COLLAGENASE 3)		5th6 MATRIX
METALLOPROTEINASE-9,
MATRIX
METALLOPROTEINASE-9
(Homo
sapiens)		5 / 6HIS A 190
HIS A 401
GLU A 402
HIS A 405
HIS A 411
 ZN  A 502 (-3.2A)
ZN  A 501 (-3.3A)
ZN  A 501 ( 4.2A)
ZN  A 501 (-3.2A)
ZN  A 501 (-3.1A)
0.30A44.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A7B_A_HAEA1273_1
(COLLAGENASE 3)		6bdz DISINTEGRIN AND
METALLOPROTEINASE
DOMAIN-CONTAINING
PROTEIN 10
(Homo
sapiens)		4 / 6HIS A 383
GLU A 384
HIS A 387
HIS A 393
 ZN  A 705 (-3.3A)
ZN  A 705 (-3.8A)
ZN  A 705 (-4.0A)
ZN  A 705 (-3.2A)
0.35A19.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A7B_B_HAEB1270_1
(COLLAGENASE 3)		1dmw PHENYLALANINE
HYDROXYLASE
(Homo
sapiens)		4 / 5LEU A 248
HIS A 285
GLU A 286
HIS A 290
HBI  A 700 ( 4.5A)
FE  A 425 (-3.4A)
None
FE  A 425 (-3.3A)
1.23A19.94
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4A7B_B_HAEB1270_1
(COLLAGENASE 3)		1hfs STROMELYSIN-1
(Homo
sapiens)		4 / 5HIS A 166
HIS A 201
GLU A 202
HIS A 205
 ZN  A 258 ( 3.0A)
ZN  A 257 ( 3.1A)
L04  A 256 ( 2.7A)
ZN  A 257 ( 3.2A)
0.26A61.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A7B_B_HAEB1270_1
(COLLAGENASE 3)		1l6j MATRIX
METALLOPROTEINASE-9
(Homo
sapiens)		5 / 5LEU A 187
HIS A 190
HIS A 401
GLU A 402
HIS A 405
None
ZN  A 501 (-3.4A)
ZN  A 500 (-3.4A)
ZN  A 500 ( 4.3A)
ZN  A 500 (-3.2A)
0.68A24.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A7B_B_HAEB1270_1
(COLLAGENASE 3)		1o5t TRYPTOPHANYL-TRNA
SYNTHETASE
(Homo
sapiens)		4 / 5LEU A 441
HIS A 130
GLU A 408
HIS A 129
None
1.33A18.35
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4A7B_B_HAEB1270_1
(COLLAGENASE 3)		1qib 72 KDA TYPE IV
COLLAGENASE
(Homo
sapiens)		5 / 5LEU A 163
HIS A 166
HIS A 201
GLU A 202
HIS A 205
None
ZN  A 502 (-3.5A)
ZN  A 501 (-3.5A)
ZN  A 501 ( 4.5A)
ZN  A 501 (-3.5A)
0.65A65.24
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4A7B_B_HAEB1270_1
(COLLAGENASE 3)		1rm8 MATRIX
METALLOPROTEINASE-16
(Homo
sapiens)		4 / 5HIS A 208
HIS A 246
GLU A 247
HIS A 250
 ZN  A 501 (-3.2A)
ZN  A 500 ( 3.3A)
BAT  A 800 (-2.7A)
ZN  A 500 ( 3.2A)
0.31A48.57
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4A7B_B_HAEB1270_1
(COLLAGENASE 3)		1slm STROMELYSIN-1
(Homo
sapiens)		4 / 5HIS A 166
HIS A 201
GLU A 202
HIS A 205
 ZN  A 258 ( 3.0A)
ZN  A 257 ( 3.0A)
ZN  A 257 ( 4.1A)
ZN  A 257 ( 3.2A)
0.15A43.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A7B_B_HAEB1270_1
(COLLAGENASE 3)		1txd RHO GUANINE
NUCLEOTIDE EXCHANGE
FACTOR 12
(Homo
sapiens)		4 / 5LEU A 943
HIS A 802
GLU A 799
HIS A 842
None
1.36A15.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A7B_B_HAEB1270_1
(COLLAGENASE 3)		1xcr HYPOTHETICAL PROTEIN
PTD012
(Homo
sapiens)		4 / 5LEU A  68
HIS A 268
GLU A 110
HIS A 278
None
ZN  A1001 ( 3.2A)
ACY  A2001 ( 3.7A)
ZN  A1001 ( 3.2A)
1.08A18.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A7B_B_HAEB1270_1
(COLLAGENASE 3)		1xcr HYPOTHETICAL PROTEIN
PTD012
(Homo
sapiens)		4 / 5LEU A  68
HIS A 278
GLU A 110
HIS A 217
None
ZN  A1001 ( 3.2A)
ACY  A2001 ( 3.7A)
None
1.09A18.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A7B_B_HAEB1270_1
(COLLAGENASE 3)		1xcr HYPOTHETICAL PROTEIN
PTD012
(Homo
sapiens)		4 / 5LEU A 157
HIS A 278
GLU A 110
HIS A 217
ACY  A2001 (-4.7A)
ZN  A1001 ( 3.2A)
ACY  A2001 ( 3.7A)
None
1.29A18.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A7B_B_HAEB1270_1
(COLLAGENASE 3)		2gli PROTEIN (FIVE-FINGER
GLI)
(Homo
sapiens)		4 / 5LEU A 148
HIS A 140
HIS A 160
HIS A 164
None
None
CO  A 259 (-3.2A)
CO  A 259 (-3.1A)
1.20A18.93
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4A7B_B_HAEB1270_1
(COLLAGENASE 3)		2jsd MATRIX
METALLOPROTEINASE-20
(Homo
sapiens)		4 / 5HIS A 191
HIS A 226
GLU A 227
HIS A 230
 ZN  A 275 (-3.4A)
NGH  A 277 ( 3.0A)
NGH  A 277 (-3.6A)
ZN  A 276 ( 3.3A)
0.79A58.18
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4A7B_B_HAEB1270_1
(COLLAGENASE 3)		2oy4 NEUTROPHIL
COLLAGENASE
(Homo
sapiens)		4 / 5HIS A 162
HIS A 197
GLU A 198
HIS A 201
 ZN  A 998 (-3.3A)
ZN  A 999 (-3.2A)
ZN  A 999 ( 4.4A)
ZN  A 999 (-3.4A)
0.16A60.74
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4A7B_B_HAEB1270_1
(COLLAGENASE 3)		2y6c MATRILYSIN
(Homo
sapiens)		4 / 5HIS A 183
HIS A 219
GLU A 220
HIS A 223
 ZN  A1266 ( 3.3A)
ZN  A1267 ( 3.2A)
TQI  A1269 (-2.9A)
ZN  A1267 ( 3.3A)
0.15A52.73
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4A7B_B_HAEB1270_1
(COLLAGENASE 3)		3ba0 MACROPHAGE
METALLOELASTASE
(Homo
sapiens)		4 / 5HIS A 183
HIS A 218
GLU A 219
HIS A 222
 ZN  A 472 (-3.1A)
ZN  A 471 (-4.0A)
ZN  A 471 ( 3.2A)
HAE  A 477 ( 3.1A)
0.59A31.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A7B_B_HAEB1270_1
(COLLAGENASE 3)		3d3l ARACHIDONATE
12-LIPOXYGENASE,
12S-TYPE
(Homo
sapiens)		4 / 5LEU A 631
HIS A 609
HIS A 392
HIS A 610
None
1.27A14.84
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4A7B_B_HAEB1270_1
(COLLAGENASE 3)		3o2x COLLAGENASE 3
(Homo
sapiens)		5 / 5LEU A1184
HIS A1187
HIS A1222
GLU A1223
HIS A1226
3O2  A1801 ( 4.5A)
ZN  A1998 ( 3.2A)
ZN  A1999 ( 3.2A)
3O2  A1801 (-2.7A)
ZN  A1999 ( 3.4A)
0.68A99.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A7B_B_HAEB1270_1
(COLLAGENASE 3)		3odx RHO GUANINE
NUCLEOTIDE EXCHANGE
FACTOR 1
(Homo
sapiens)		4 / 5LEU A 571
HIS A 431
GLU A 428
HIS A 471
None
1.38A16.03
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4A7B_B_HAEB1270_1
(COLLAGENASE 3)		3shi INTERSTITIAL
COLLAGENASE
(Homo
sapiens)		4 / 5HIS A 183
HIS A 218
GLU A 219
HIS A 222
 ZN  A 302 (-3.1A)
ZN  A 301 (-3.3A)
ZN  A 301 ( 4.7A)
ZN  A 301 (-3.4A)
0.25A58.28
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4A7B_B_HAEB1270_1
(COLLAGENASE 3)		3v96 STROMELYSIN-2
(Homo
sapiens)		4 / 5HIS B 182
HIS B 217
GLU B 218
HIS B 221
 ZN  B 302 (-3.2A)
ZN  B 301 (-3.2A)
ZN  B 301 ( 3.9A)
ZN  B 301 (-3.3A)
0.14A62.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A7B_B_HAEB1270_1
(COLLAGENASE 3)		3zwf ZINC
PHOSPHODIESTERASE
ELAC PROTEIN 1
(Homo
sapiens)		4 / 5LEU A 180
HIS A 313
GLU A 275
HIS A 291
None
ZN  A1363 ( 3.4A)
None
PO4  A1365 (-3.8A)
1.26A17.57
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4A7B_B_HAEB1270_1
(COLLAGENASE 3)		4fvl COLLAGENASE 3
(Homo
sapiens)		4 / 5LEU A 184
HIS A 187
HIS A 222
HIS A 226
None
ZN  A 502 (-3.3A)
ZN  A 501 (-3.3A)
ZN  A 501 (-3.1A)
0.72A99.41
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4A7B_B_HAEB1270_1
(COLLAGENASE 3)		4gr8 MACROPHAGE
METALLOELASTASE
(Homo
sapiens)		4 / 5HIS A 183
HIS A 218
GLU A 219
HIS A 222
 ZN  A 302 (-3.2A)
R4C  A 306 ( 3.2A)
R4C  A 306 (-2.7A)
ZN  A 301 ( 3.2A)
0.18A58.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A7B_B_HAEB1270_1
(COLLAGENASE 3)		4h1s 5'-NUCLEOTIDASE
(Homo
sapiens)		4 / 5LEU A 184
HIS A 437
GLU A 448
HIS A 440
None
1.13A14.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A7B_B_HAEB1270_1
(COLLAGENASE 3)		4pvg TYROSINE-PROTEIN
PHOSPHATASE
NON-RECEPTOR TYPE 11
(Homo
sapiens)		4 / 5LEU A 525
HIS A 443
GLU A 440
HIS A 444
None
1.30A18.39
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4A7B_B_HAEB1270_1
(COLLAGENASE 3)		4xct MATRIX
METALLOPROTEINASE-9,
MATRIX
METALLOPROTEINASE-9
(Homo
sapiens)		5 / 5LEU A 187
HIS A 190
HIS A 226
GLU A 227
HIS A 230
N73  A 301 (-4.0A)
ZN  A 303 ( 3.2A)
ZN  A 302 ( 3.2A)
N73  A 301 (-2.5A)
ZN  A 302 ( 3.3A)
0.67A57.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A7B_B_HAEB1270_1
(COLLAGENASE 3)		5ec3 4-HYDROXYPHENYLPYRUV
ATE DIOXYGENASE
(Homo
sapiens)		4 / 5LEU A 323
HIS A 183
GLU A 349
HIS A 266
LEU  A 323 ( 0.6A)
HIS  A 183 (-1.0A)
GLU  A 349 (-0.6A)
HIS  A 266 (-1.0A)
1.32A18.72
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4A7B_B_HAEB1270_1
(COLLAGENASE 3)		5h0u MATRIX
METALLOPROTEINASE-14
(Homo
sapiens)		4 / 5HIS A 201
HIS A 239
GLU A 240
HIS A 243
 ZN  A 303 (-3.2A)
ZN  A 302 ( 3.3A)
GOL  A 311 (-4.2A)
ZN  A 302 (-3.4A)
0.17A48.02
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4A7B_B_HAEB1270_1
(COLLAGENASE 3)		5th6 MATRIX
METALLOPROTEINASE-9,
MATRIX
METALLOPROTEINASE-9
(Homo
sapiens)		5 / 5LEU A 187
HIS A 190
HIS A 401
GLU A 402
HIS A 405
None
ZN  A 502 (-3.2A)
ZN  A 501 (-3.3A)
ZN  A 501 ( 4.2A)
ZN  A 501 (-3.2A)
0.61A44.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A7B_B_HAEB1270_1
(COLLAGENASE 3)		6amw TYROSINE-PROTEIN
KINASE ABL1
(Homo
sapiens)		4 / 5LEU A  61
HIS A 114
GLU A 117
HIS A  21
None
1.25A20.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4H9M_A_HAEA929_1
(UREASE)		2i7t CLEAVAGE AND
POLYADENYLATION
SPECIFICITY FACTOR
73 KDA SUBUNIT
(Homo
sapiens)		5 / 5HIS A  76
HIS A 158
HIS A 396
HIS A 418
ASP A  75
 ZN  A 481 (-3.4A)
ZN  A 482 ( 3.3A)
SO4  A 491 (-4.0A)
ZN  A 481 ( 3.4A)
ZN  A 481 ( 2.6A)
1.17A22.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4H9M_A_HAEA929_1
(UREASE)		2vr2 DIHYDROPYRIMIDINASE
(Homo
sapiens)		4 / 5HIS A  67
HIS A 192
HIS A 248
ASP A 326
 ZN  A1494 (-3.3A)
ZN  A1495 (-3.7A)
ZN  A1495 (-3.4A)
ZN  A1494 (-2.7A)
0.69A21.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4H9M_A_HAEA929_1
(UREASE)		2y1h PUTATIVE
DEOXYRIBONUCLEASE
TATDN3
(Homo
sapiens)		4 / 5HIS A  12
HIS A  70
HIS A 147
ASP A 218
 ZN  A1274 ( 3.2A)
PO4  A1275 (-3.8A)
ZN  A1273 ( 3.1A)
PO4  A1275 ( 2.7A)
0.56A15.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4H9M_A_HAEA929_1
(UREASE)		3zwf ZINC
PHOSPHODIESTERASE
ELAC PROTEIN 1
(Homo
sapiens)		4 / 5HIS A  67
HIS A 182
HIS A 313
ASP A  66
 ZN  A1363 (-3.4A)
ZN  A1364 ( 3.5A)
ZN  A1363 ( 3.4A)
ZN  A1363 ( 2.6A)
0.92A17.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4H9M_A_HAEA929_1
(UREASE)		4c6o CAD PROTEIN
(Homo
sapiens)		4 / 5HIS A1471
HIS A1590
HIS A1614
ASP A1686
 ZN  A2822 ( 3.2A)
ZN  A2823 (-3.0A)
ZN  A2823 (-3.2A)
ZN  A2822 (-2.6A)
0.59A19.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4H9M_A_HAEA929_1
(UREASE)		4zyo ACYL-COA DESATURASE
(Homo
sapiens)		4 / 5HIS A 269
HIS A 157
HIS A 161
HIS A 302
 ZN  A 402 (-3.2A)
ZN  A 401 ( 3.2A)
ZN  A 401 (-3.3A)
ZN  A 402 (-3.5A)
0.94A16.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4H9M_A_HAEA929_1
(UREASE)		5ao0 DEOXYNUCLEOSIDE
TRIPHOSPHATE
TRIPHOSPHOHYDROLASE
SAMHD1
(Homo
sapiens)		4 / 5HIS A 206
HIS A 210
HIS A 233
ASP A 311
 FE  A1001 ( 3.2A)
DG3  A2001 (-4.6A)
DG3  A2001 (-3.4A)
FE  A1001 ( 2.6A)
0.91A22.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UBP_C_HAEC800_1
(PROTEIN (UREASE
(CHAIN C)))		2i7t CLEAVAGE AND
POLYADENYLATION
SPECIFICITY FACTOR
73 KDA SUBUNIT
(Homo
sapiens)		5 / 6HIS A  76
HIS A 158
HIS A 396
HIS A 418
ASP A  75
 ZN  A 481 (-3.4A)
ZN  A 482 ( 3.3A)
SO4  A 491 (-4.0A)
ZN  A 481 ( 3.4A)
ZN  A 481 ( 2.6A)
1.17A22.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UBP_C_HAEC800_1
(PROTEIN (UREASE
(CHAIN C)))		2ibn INOSITOL OXYGENASE
(Homo
sapiens)		5 / 6HIS A 123
HIS A  98
HIS A 194
HIS A 220
ASP A 253
 FE  A 703 (-3.3A)
FE  A 703 (-3.2A)
FE  A 704 ( 3.5A)
FE  A 704 ( 3.4A)
FE  A 703 (-2.5A)
1.03A17.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UBP_C_HAEC800_1
(PROTEIN (UREASE
(CHAIN C)))		2vr2 DIHYDROPYRIMIDINASE
(Homo
sapiens)		5 / 6HIS A  67
HIS A  69
HIS A 192
HIS A 248
ASP A 326
 ZN  A1494 (-3.3A)
ZN  A1494 (-3.3A)
ZN  A1495 (-3.7A)
ZN  A1495 (-3.4A)
ZN  A1494 (-2.7A)
0.67A23.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UBP_C_HAEC800_1
(PROTEIN (UREASE
(CHAIN C)))		2y1h PUTATIVE
DEOXYRIBONUCLEASE
TATDN3
(Homo
sapiens)		5 / 6HIS A  12
HIS A  14
HIS A  70
HIS A 147
ASP A 218
 ZN  A1274 ( 3.2A)
ZN  A1274 ( 3.3A)
PO4  A1275 (-3.8A)
ZN  A1273 ( 3.1A)
PO4  A1275 ( 2.7A)
0.54A17.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UBP_C_HAEC800_1
(PROTEIN (UREASE
(CHAIN C)))		2y1h PUTATIVE
DEOXYRIBONUCLEASE
TATDN3
(Homo
sapiens)		5 / 6HIS A  14
HIS A  70
HIS A 147
HIS A 170
ASP A 218
 ZN  A1274 ( 3.3A)
PO4  A1275 (-3.8A)
ZN  A1273 ( 3.1A)
ZN  A1273 (-3.2A)
PO4  A1275 ( 2.7A)
0.99A17.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UBP_C_HAEC800_1
(PROTEIN (UREASE
(CHAIN C)))		4c6o CAD PROTEIN
(Homo
sapiens)		5 / 6HIS A1471
HIS A1473
HIS A1590
HIS A1614
ASP A1686
 ZN  A2822 ( 3.2A)
ZN  A2822 ( 3.2A)
ZN  A2823 (-3.0A)
ZN  A2823 (-3.2A)
ZN  A2822 (-2.6A)
0.45A21.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UBP_C_HAEC800_1
(PROTEIN (UREASE
(CHAIN C)))		5ao0 DEOXYNUCLEOSIDE
TRIPHOSPHATE
TRIPHOSPHOHYDROLASE
SAMHD1
(Homo
sapiens)		5 / 6HIS A 206
HIS A 167
HIS A 210
HIS A 233
ASP A 311
 FE  A1001 ( 3.2A)
FE  A1001 ( 3.6A)
DG3  A2001 (-4.6A)
DG3  A2001 (-3.4A)
FE  A1001 ( 2.6A)
1.06A23.87
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5N5J_A_HAEA306_1
(MACROPHAGE
METALLOELASTASE)		1hfs STROMELYSIN-1
(Homo
sapiens)		4 / 4HIS A 201
GLU A 202
HIS A 205
HIS A 211
 ZN  A 257 ( 3.1A)
L04  A 256 ( 2.7A)
ZN  A 257 ( 3.2A)
ZN  A 257 ( 3.1A)
0.21A59.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5N5J_A_HAEA306_1
(MACROPHAGE
METALLOELASTASE)		1l6j MATRIX
METALLOPROTEINASE-9
(Homo
sapiens)		4 / 4HIS A 401
GLU A 402
HIS A 405
HIS A 411
 ZN  A 500 (-3.4A)
ZN  A 500 ( 4.3A)
ZN  A 500 (-3.2A)
ZN  A 500 (-3.4A)
0.24A23.22
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5N5J_A_HAEA306_1
(MACROPHAGE
METALLOELASTASE)		1qib 72 KDA TYPE IV
COLLAGENASE
(Homo
sapiens)		4 / 4HIS A 201
GLU A 202
HIS A 205
HIS A 211
 ZN  A 501 (-3.5A)
ZN  A 501 ( 4.5A)
ZN  A 501 (-3.5A)
ZN  A 501 (-3.5A)
0.30A59.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5N5J_A_HAEA306_1
(MACROPHAGE
METALLOELASTASE)		1r55 ADAM 33
(Homo
sapiens)		4 / 4HIS A 345
GLU A 346
HIS A 349
HIS A 355
 ZN  A 201 ( 3.3A)
097  A 518 (-2.9A)
ZN  A 201 ( 3.2A)
ZN  A 201 ( 3.3A)
0.28A25.33
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5N5J_A_HAEA306_1
(MACROPHAGE
METALLOELASTASE)		1rm8 MATRIX
METALLOPROTEINASE-16
(Homo
sapiens)		4 / 4HIS A 246
GLU A 247
HIS A 250
HIS A 256
 ZN  A 500 ( 3.3A)
BAT  A 800 (-2.7A)
ZN  A 500 ( 3.2A)
ZN  A 500 ( 3.3A)
0.18A51.19
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5N5J_A_HAEA306_1
(MACROPHAGE
METALLOELASTASE)		1slm STROMELYSIN-1
(Homo
sapiens)		4 / 4HIS A 201
GLU A 202
HIS A 205
HIS A 211
 ZN  A 257 ( 3.0A)
ZN  A 257 ( 4.1A)
ZN  A 257 ( 3.2A)
ZN  A 257 ( 3.1A)
0.24A46.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5N5J_A_HAEA306_1
(MACROPHAGE
METALLOELASTASE)		1xcr HYPOTHETICAL PROTEIN
PTD012
(Homo
sapiens)		4 / 4HIS A 268
GLU A 110
HIS A 278
HIS A 266
 ZN  A1001 ( 3.2A)
ACY  A2001 ( 3.7A)
ZN  A1001 ( 3.2A)
ZN  A1001 ( 3.2A)
0.95A19.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5N5J_A_HAEA306_1
(MACROPHAGE
METALLOELASTASE)		2fv5 ADAM 17
(Homo
sapiens)		4 / 4HIS A 405
GLU A 406
HIS A 409
HIS A 415
 ZN  A   3 ( 3.2A)
541  A   1 (-2.6A)
ZN  A   3 ( 3.3A)
ZN  A   3 ( 3.2A)
0.25A23.08
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5N5J_A_HAEA306_1
(MACROPHAGE
METALLOELASTASE)		2jsd MATRIX
METALLOPROTEINASE-20
(Homo
sapiens)		4 / 4HIS A 226
GLU A 227
HIS A 230
HIS A 236
NGH  A 277 ( 3.0A)
NGH  A 277 (-3.6A)
ZN  A 276 ( 3.3A)
ZN  A 276 ( 3.0A)
0.63A54.72
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5N5J_A_HAEA306_1
(MACROPHAGE
METALLOELASTASE)		2oy4 NEUTROPHIL
COLLAGENASE
(Homo
sapiens)		4 / 4HIS A 197
GLU A 198
HIS A 201
HIS A 207
 ZN  A 999 (-3.2A)
ZN  A 999 ( 4.4A)
ZN  A 999 (-3.4A)
ZN  A 999 (-3.2A)
0.13A53.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5N5J_A_HAEA306_1
(MACROPHAGE
METALLOELASTASE)		2rjq ADAMTS-5
(Homo
sapiens)		4 / 4HIS A 410
GLU A 411
HIS A 414
HIS A 420
 ZN  A   1 ( 3.2A)
BAT  A 559 (-2.5A)
ZN  A   1 ( 3.3A)
ZN  A   1 ( 3.3A)
0.16A16.08
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5N5J_A_HAEA306_1
(MACROPHAGE
METALLOELASTASE)		2y6c MATRILYSIN
(Homo
sapiens)		4 / 4HIS A 219
GLU A 220
HIS A 223
HIS A 229
 ZN  A1267 ( 3.2A)
TQI  A1269 (-2.9A)
ZN  A1267 ( 3.3A)
ZN  A1267 ( 3.2A)
0.19A54.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5N5J_A_HAEA306_1
(MACROPHAGE
METALLOELASTASE)		3b8z PROTEIN ADAMTS-5
(Homo
sapiens)		4 / 4HIS A 410
GLU A 411
HIS A 414
HIS A 420
 ZN  A 901 ( 3.2A)
294  A 801 (-2.7A)
ZN  A 901 ( 3.3A)
ZN  A 901 ( 3.3A)
0.15A23.72
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5N5J_A_HAEA306_1
(MACROPHAGE
METALLOELASTASE)		3ba0 MACROPHAGE
METALLOELASTASE
(Homo
sapiens)		4 / 4HIS A 218
GLU A 219
HIS A 222
HIS A 228
 ZN  A 471 (-4.0A)
ZN  A 471 ( 3.2A)
HAE  A 477 ( 3.1A)
ZN  A 471 (-3.7A)
0.41A100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5N5J_A_HAEA306_1
(MACROPHAGE
METALLOELASTASE)		3edi TOLLOID-LIKE PROTEIN
1
(Homo
sapiens)		4 / 4HIS A  92
GLU A  93
HIS A  96
HIS A 102
 ZN  A 210 (-3.2A)
ZN  A 210 ( 4.3A)
ZN  A 210 (-3.3A)
ZN  A 210 (-3.2A)
0.17A24.14
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5N5J_A_HAEA306_1
(MACROPHAGE
METALLOELASTASE)		3o2x COLLAGENASE 3
(Homo
sapiens)		4 / 4HIS A1222
GLU A1223
HIS A1226
HIS A1232
 ZN  A1999 ( 3.2A)
3O2  A1801 (-2.7A)
ZN  A1999 ( 3.4A)
ZN  A1999 ( 3.2A)
0.22A56.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5N5J_A_HAEA306_1
(MACROPHAGE
METALLOELASTASE)		3q2h A DISINTEGRIN AND
METALLOPROTEINASE
WITH THROMBOSPONDIN
MOTIFS 1
(Homo
sapiens)		4 / 4HIS A 149
GLU A 150
HIS A 153
HIS A 159
 ZN  A 401 ( 3.3A)
QHF  A   1 (-2.6A)
QHF  A   1 ( 3.0A)
ZN  A 401 ( 3.2A)
0.17A18.87
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5N5J_A_HAEA306_1
(MACROPHAGE
METALLOELASTASE)		3shi INTERSTITIAL
COLLAGENASE
(Homo
sapiens)		4 / 4HIS A 218
GLU A 219
HIS A 222
HIS A 228
 ZN  A 301 (-3.3A)
ZN  A 301 ( 4.7A)
ZN  A 301 (-3.4A)
ZN  A 301 (-3.3A)
0.25A58.02
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5N5J_A_HAEA306_1
(MACROPHAGE
METALLOELASTASE)		3v96 STROMELYSIN-2
(Homo
sapiens)		4 / 4HIS B 217
GLU B 218
HIS B 221
HIS B 227
 ZN  B 301 (-3.2A)
ZN  B 301 ( 3.9A)
ZN  B 301 (-3.3A)
ZN  B 301 (-3.2A)
0.27A57.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5N5J_A_HAEA306_1
(MACROPHAGE
METALLOELASTASE)		4dd8 DISINTEGRIN AND
METALLOPROTEINASE
DOMAIN-CONTAINING
PROTEIN 8
(Homo
sapiens)		4 / 4HIS A 334
GLU A 335
HIS A 338
HIS A 344
 ZN  A1002 ( 3.3A)
BAT  A1000 (-2.7A)
ZN  A1002 (-3.3A)
ZN  A1002 ( 3.3A)
0.39A19.91
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5N5J_A_HAEA306_1
(MACROPHAGE
METALLOELASTASE)		4gr8 MACROPHAGE
METALLOELASTASE
(Homo
sapiens)		4 / 4HIS A 218
GLU A 219
HIS A 222
HIS A 228
R4C  A 306 ( 3.2A)
R4C  A 306 (-2.7A)
ZN  A 301 ( 3.2A)
ZN  A 301 ( 3.2A)
0.21A100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5N5J_A_HAEA306_1
(MACROPHAGE
METALLOELASTASE)		4gwn MEPRIN A SUBUNIT
BETA
(Homo
sapiens)		4 / 4HIS A 152
GLU A 153
HIS A 156
HIS A 162
 CD  A 701 (-3.7A)
CD  A 701 (-3.5A)
CD  A 701 (-3.7A)
CD  A 701 (-3.7A)
0.29A14.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5N5J_A_HAEA306_1
(MACROPHAGE
METALLOELASTASE)		4qgn 1,2-DIHYDROXY-3-KETO
-5-METHYLTHIOPENTENE
DIOXYGENASE
(Homo
sapiens)		4 / 4HIS A 133
GLU A  94
HIS A  90
HIS A  88
 FE  A 201 (-3.3A)
FE  A 201 ( 2.7A)
FE  A 201 (-3.3A)
FE  A 201 (-3.4A)
1.06A20.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5N5J_A_HAEA306_1
(MACROPHAGE
METALLOELASTASE)		4wk7 A DISINTEGRIN AND
METALLOPROTEINASE
WITH THROMBOSPONDIN
MOTIFS 4
(Homo
sapiens)		4 / 4HIS A 361
GLU A 362
HIS A 365
HIS A 371
 ZN  A 501 ( 3.2A)
3PQ  A 505 (-2.6A)
ZN  A 501 ( 3.3A)
ZN  A 501 ( 3.2A)
0.23A19.67
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5N5J_A_HAEA306_1
(MACROPHAGE
METALLOELASTASE)		4xct MATRIX
METALLOPROTEINASE-9,
MATRIX
METALLOPROTEINASE-9
(Homo
sapiens)		4 / 4HIS A 226
GLU A 227
HIS A 230
HIS A 236
 ZN  A 302 ( 3.2A)
N73  A 301 (-2.5A)
ZN  A 302 ( 3.3A)
ZN  A 302 ( 3.3A)
0.09A50.31
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5N5J_A_HAEA306_1
(MACROPHAGE
METALLOELASTASE)		5h0u MATRIX
METALLOPROTEINASE-14
(Homo
sapiens)		4 / 4HIS A 239
GLU A 240
HIS A 243
HIS A 249
 ZN  A 302 ( 3.3A)
GOL  A 311 (-4.2A)
ZN  A 302 (-3.4A)
ZN  A 302 (-3.2A)
0.13A50.89
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5N5J_A_HAEA306_1
(MACROPHAGE
METALLOELASTASE)		5th6 MATRIX
METALLOPROTEINASE-9,
MATRIX
METALLOPROTEINASE-9
(Homo
sapiens)		4 / 4HIS A 401
GLU A 402
HIS A 405
HIS A 411
 ZN  A 501 (-3.3A)
ZN  A 501 ( 4.2A)
ZN  A 501 (-3.2A)
ZN  A 501 (-3.1A)
0.21A40.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5N5J_A_HAEA306_1
(MACROPHAGE
METALLOELASTASE)		6bdz DISINTEGRIN AND
METALLOPROTEINASE
DOMAIN-CONTAINING
PROTEIN 10
(Homo
sapiens)		4 / 4HIS A 383
GLU A 384
HIS A 387
HIS A 393
 ZN  A 705 (-3.3A)
ZN  A 705 (-3.8A)
ZN  A 705 (-4.0A)
ZN  A 705 (-3.2A)
0.48A20.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5N5K_A_HAEA306_1
(MACROPHAGE
METALLOELASTASE)		1hfs STROMELYSIN-1
(Homo
sapiens)		4 / 5HIS A 201
GLU A 202
HIS A 205
HIS A 211
 ZN  A 257 ( 3.1A)
L04  A 256 ( 2.7A)
ZN  A 257 ( 3.2A)
ZN  A 257 ( 3.1A)
0.22A58.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5N5K_A_HAEA306_1
(MACROPHAGE
METALLOELASTASE)		1l6j MATRIX
METALLOPROTEINASE-9
(Homo
sapiens)		4 / 5HIS A 401
GLU A 402
HIS A 405
HIS A 411
 ZN  A 500 (-3.4A)
ZN  A 500 ( 4.3A)
ZN  A 500 (-3.2A)
ZN  A 500 (-3.4A)
0.23A20.14
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5N5K_A_HAEA306_1
(MACROPHAGE
METALLOELASTASE)		1qib 72 KDA TYPE IV
COLLAGENASE
(Homo
sapiens)		4 / 5HIS A 201
GLU A 202
HIS A 205
HIS A 211
 ZN  A 501 (-3.5A)
ZN  A 501 ( 4.5A)
ZN  A 501 (-3.5A)
ZN  A 501 (-3.5A)
0.32A58.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5N5K_A_HAEA306_1
(MACROPHAGE
METALLOELASTASE)		1r55 ADAM 33
(Homo
sapiens)		4 / 5HIS A 345
GLU A 346
HIS A 349
HIS A 355
 ZN  A 201 ( 3.3A)
097  A 518 (-2.9A)
ZN  A 201 ( 3.2A)
ZN  A 201 ( 3.3A)
0.30A25.33
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5N5K_A_HAEA306_1
(MACROPHAGE
METALLOELASTASE)		1rm8 MATRIX
METALLOPROTEINASE-16
(Homo
sapiens)		4 / 5HIS A 246
GLU A 247
HIS A 250
HIS A 256
 ZN  A 500 ( 3.3A)
BAT  A 800 (-2.7A)
ZN  A 500 ( 3.2A)
ZN  A 500 ( 3.3A)
0.16A50.60
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5N5K_A_HAEA306_1
(MACROPHAGE
METALLOELASTASE)		1slm STROMELYSIN-1
(Homo
sapiens)		4 / 5HIS A 201
GLU A 202
HIS A 205
HIS A 211
 ZN  A 257 ( 3.0A)
ZN  A 257 ( 4.1A)
ZN  A 257 ( 3.2A)
ZN  A 257 ( 3.1A)
0.19A40.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5N5K_A_HAEA306_1
(MACROPHAGE
METALLOELASTASE)		1xcr HYPOTHETICAL PROTEIN
PTD012
(Homo
sapiens)		4 / 5HIS A 268
GLU A 110
HIS A 278
HIS A 266
 ZN  A1001 ( 3.2A)
ACY  A2001 ( 3.7A)
ZN  A1001 ( 3.2A)
ZN  A1001 ( 3.2A)
0.95A18.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5N5K_A_HAEA306_1
(MACROPHAGE
METALLOELASTASE)		2fv5 ADAM 17
(Homo
sapiens)		4 / 5HIS A 405
GLU A 406
HIS A 409
HIS A 415
 ZN  A   3 ( 3.2A)
541  A   1 (-2.6A)
ZN  A   3 ( 3.3A)
ZN  A   3 ( 3.2A)
0.25A24.26
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5N5K_A_HAEA306_1
(MACROPHAGE
METALLOELASTASE)		2jsd MATRIX
METALLOPROTEINASE-20
(Homo
sapiens)		4 / 5HIS A 226
GLU A 227
HIS A 230
HIS A 236
NGH  A 277 ( 3.0A)
NGH  A 277 (-3.6A)
ZN  A 276 ( 3.3A)
ZN  A 276 ( 3.0A)
0.62A53.46
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5N5K_A_HAEA306_1
(MACROPHAGE
METALLOELASTASE)		2oy4 NEUTROPHIL
COLLAGENASE
(Homo
sapiens)		5 / 5ILE A 159
HIS A 197
GLU A 198
HIS A 201
HIS A 207
None
ZN  A 999 (-3.2A)
ZN  A 999 ( 4.4A)
ZN  A 999 (-3.4A)
ZN  A 999 (-3.2A)
0.56A53.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5N5K_A_HAEA306_1
(MACROPHAGE
METALLOELASTASE)		2rjq ADAMTS-5
(Homo
sapiens)		4 / 5HIS A 410
GLU A 411
HIS A 414
HIS A 420
 ZN  A   1 ( 3.2A)
BAT  A 559 (-2.5A)
ZN  A   1 ( 3.3A)
ZN  A   1 ( 3.3A)
0.15A16.39
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5N5K_A_HAEA306_1
(MACROPHAGE
METALLOELASTASE)		2y6c MATRILYSIN
(Homo
sapiens)		4 / 5HIS A 219
GLU A 220
HIS A 223
HIS A 229
 ZN  A1267 ( 3.2A)
TQI  A1269 (-2.9A)
ZN  A1267 ( 3.3A)
ZN  A1267 ( 3.2A)
0.20A56.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5N5K_A_HAEA306_1
(MACROPHAGE
METALLOELASTASE)		3b8z PROTEIN ADAMTS-5
(Homo
sapiens)		4 / 5HIS A 410
GLU A 411
HIS A 414
HIS A 420
 ZN  A 901 ( 3.2A)
294  A 801 (-2.7A)
ZN  A 901 ( 3.3A)
ZN  A 901 ( 3.3A)
0.14A24.29
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5N5K_A_HAEA306_1
(MACROPHAGE
METALLOELASTASE)		3ba0 MACROPHAGE
METALLOELASTASE
(Homo
sapiens)		5 / 5ILE A 180
HIS A 218
GLU A 219
HIS A 222
HIS A 228
None
ZN  A 471 (-4.0A)
ZN  A 471 ( 3.2A)
HAE  A 477 ( 3.1A)
ZN  A 471 (-3.7A)
0.73A100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5N5K_A_HAEA306_1
(MACROPHAGE
METALLOELASTASE)		3edi TOLLOID-LIKE PROTEIN
1
(Homo
sapiens)		4 / 5HIS A  92
GLU A  93
HIS A  96
HIS A 102
 ZN  A 210 (-3.2A)
ZN  A 210 ( 4.3A)
ZN  A 210 (-3.3A)
ZN  A 210 (-3.2A)
0.14A23.12
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5N5K_A_HAEA306_1
(MACROPHAGE
METALLOELASTASE)		3o2x COLLAGENASE 3
(Homo
sapiens)		4 / 5HIS A1222
GLU A1223
HIS A1226
HIS A1232
 ZN  A1999 ( 3.2A)
3O2  A1801 (-2.7A)
ZN  A1999 ( 3.4A)
ZN  A1999 ( 3.2A)
0.18A56.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5N5K_A_HAEA306_1
(MACROPHAGE
METALLOELASTASE)		3q2h A DISINTEGRIN AND
METALLOPROTEINASE
WITH THROMBOSPONDIN
MOTIFS 1
(Homo
sapiens)		4 / 5HIS A 149
GLU A 150
HIS A 153
HIS A 159
 ZN  A 401 ( 3.3A)
QHF  A   1 (-2.6A)
QHF  A   1 ( 3.0A)
ZN  A 401 ( 3.2A)
0.17A18.87
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5N5K_A_HAEA306_1
(MACROPHAGE
METALLOELASTASE)		3shi INTERSTITIAL
COLLAGENASE
(Homo
sapiens)		4 / 5HIS A 218
GLU A 219
HIS A 222
HIS A 228
 ZN  A 301 (-3.3A)
ZN  A 301 ( 4.7A)
ZN  A 301 (-3.4A)
ZN  A 301 (-3.3A)
0.28A57.41
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5N5K_A_HAEA306_1
(MACROPHAGE
METALLOELASTASE)		3v96 STROMELYSIN-2
(Homo
sapiens)		4 / 5HIS B 217
GLU B 218
HIS B 221
HIS B 227
 ZN  B 301 (-3.2A)
ZN  B 301 ( 3.9A)
ZN  B 301 (-3.3A)
ZN  B 301 (-3.2A)
0.23A57.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5N5K_A_HAEA306_1
(MACROPHAGE
METALLOELASTASE)		4dd8 DISINTEGRIN AND
METALLOPROTEINASE
DOMAIN-CONTAINING
PROTEIN 8
(Homo
sapiens)		4 / 5HIS A 334
GLU A 335
HIS A 338
HIS A 344
 ZN  A1002 ( 3.3A)
BAT  A1000 (-2.7A)
ZN  A1002 (-3.3A)
ZN  A1002 ( 3.3A)
0.40A21.27
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5N5K_A_HAEA306_1
(MACROPHAGE
METALLOELASTASE)		4gr8 MACROPHAGE
METALLOELASTASE
(Homo
sapiens)		5 / 5ILE A 180
HIS A 218
GLU A 219
HIS A 222
HIS A 228
R4C  A 306 (-4.3A)
R4C  A 306 ( 3.2A)
R4C  A 306 (-2.7A)
ZN  A 301 ( 3.2A)
ZN  A 301 ( 3.2A)
0.27A100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5N5K_A_HAEA306_1
(MACROPHAGE
METALLOELASTASE)		4gwn MEPRIN A SUBUNIT
BETA
(Homo
sapiens)		4 / 5HIS A 152
GLU A 153
HIS A 156
HIS A 162
 CD  A 701 (-3.7A)
CD  A 701 (-3.5A)
CD  A 701 (-3.7A)
CD  A 701 (-3.7A)
0.25A13.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5N5K_A_HAEA306_1
(MACROPHAGE
METALLOELASTASE)		4qgn 1,2-DIHYDROXY-3-KETO
-5-METHYLTHIOPENTENE
DIOXYGENASE
(Homo
sapiens)		4 / 5HIS A 133
GLU A  94
HIS A  90
HIS A  88
 FE  A 201 (-3.3A)
FE  A 201 ( 2.7A)
FE  A 201 (-3.3A)
FE  A 201 (-3.4A)
1.02A20.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5N5K_A_HAEA306_1
(MACROPHAGE
METALLOELASTASE)		4wk7 A DISINTEGRIN AND
METALLOPROTEINASE
WITH THROMBOSPONDIN
MOTIFS 4
(Homo
sapiens)		4 / 5HIS A 361
GLU A 362
HIS A 365
HIS A 371
 ZN  A 501 ( 3.2A)
3PQ  A 505 (-2.6A)
ZN  A 501 ( 3.3A)
ZN  A 501 ( 3.2A)
0.26A19.67
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5N5K_A_HAEA306_1
(MACROPHAGE
METALLOELASTASE)		4xct MATRIX
METALLOPROTEINASE-9,
MATRIX
METALLOPROTEINASE-9
(Homo
sapiens)		4 / 5HIS A 226
GLU A 227
HIS A 230
HIS A 236
 ZN  A 302 ( 3.2A)
N73  A 301 (-2.5A)
ZN  A 302 ( 3.3A)
ZN  A 302 ( 3.3A)
0.10A50.31
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5N5K_A_HAEA306_1
(MACROPHAGE
METALLOELASTASE)		5h0u MATRIX
METALLOPROTEINASE-14
(Homo
sapiens)		4 / 5HIS A 239
GLU A 240
HIS A 243
HIS A 249
 ZN  A 302 ( 3.3A)
GOL  A 311 (-4.2A)
ZN  A 302 (-3.4A)
ZN  A 302 (-3.2A)
0.15A50.30
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5N5K_A_HAEA306_1
(MACROPHAGE
METALLOELASTASE)		5th6 MATRIX
METALLOPROTEINASE-9,
MATRIX
METALLOPROTEINASE-9
(Homo
sapiens)		4 / 5HIS A 401
GLU A 402
HIS A 405
HIS A 411
 ZN  A 501 (-3.3A)
ZN  A 501 ( 4.2A)
ZN  A 501 (-3.2A)
ZN  A 501 (-3.1A)
0.17A37.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5N5K_A_HAEA306_1
(MACROPHAGE
METALLOELASTASE)		6bdz DISINTEGRIN AND
METALLOPROTEINASE
DOMAIN-CONTAINING
PROTEIN 10
(Homo
sapiens)		4 / 5HIS A 383
GLU A 384
HIS A 387
HIS A 393
 ZN  A 705 (-3.3A)
ZN  A 705 (-3.8A)
ZN  A 705 (-4.0A)
ZN  A 705 (-3.2A)
0.44A20.26