POTENTIAL TARGETS FROM HUMAN (RESULTS FROM SUB-STRUCTURAL SIMILARITY SEARCHES)1) User may click on the DrReposER ID (the second column) to get information on the binding sites and drug molecule.
2) Click View (the second last column) to view matched residues and superposition in the NGL viewer (upper right part).
3) User may also click on the Dock (the last column) to get script for molecular docking in UCSF Chimera through AutoDock Vina.

	DrReposER ID / Desc.	Hit PDBID	Hit Macromolecule	Res. Matches	Interface	HETATM	RMSD	Seq. Identity (%)	View	Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	6DRZ_A_H8JA1206_0 (5HT2B RECEPTOR, BRIL CHIMERA)	1bey	CAMPATH-1H ANTIBODY (Homo sapiens)	5 / 12	VAL H 215 THR H 213 VAL H 219 GLY H 126 VAL H 160	None	0.91A	18.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	6DRZ_A_H8JA1206_0 (5HT2B RECEPTOR, BRIL CHIMERA)	1hci	ALPHA-ACTININ 2 (Homo sapiens)	5 / 12	VAL A 614 LEU A 565 PHE A 561 GLY A 534 PHE A 528	None	1.13A	20.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	6DRZ_A_H8JA1206_0 (5HT2B RECEPTOR, BRIL CHIMERA)	1rz8	FAB 17B HEAVY CHAIN (Homo sapiens)	5 / 12	VAL B 207 THR B 205 VAL B 211 GLY B 118 VAL B 152	None	1.00A	19.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	6DRZ_A_H8JA1206_0 (5HT2B RECEPTOR, BRIL CHIMERA)	1rzf	FAB E51 HEAVY CHAIN (Homo sapiens)	5 / 12	VAL H 207 THR H 205 VAL H 211 GLY H 118 VAL H 152	GOL  H9007 ( 4.9A) None None None None	1.05A	17.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	6DRZ_A_H8JA1206_0 (5HT2B RECEPTOR, BRIL CHIMERA)	1v5w	MEIOTIC RECOMBINATION PROTEIN DMC1/LIM15 HOMOLOG (Homo sapiens)	5 / 12	SER A 136 THR A 138 LEU A 303 PHE A 328 GLY A 334	None	1.11A	23.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	6DRZ_A_H8JA1206_0 (5HT2B RECEPTOR, BRIL CHIMERA)	2eh0	KINESIN-LIKE PROTEIN KIF1B (Homo sapiens)	5 / 12	THR A  82 VAL A  12 LEU A  11 PHE A  60 ASN A  99	None	1.15A	14.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	6DRZ_A_H8JA1206_0 (5HT2B RECEPTOR, BRIL CHIMERA)	2id5	LEUCINE RICH REPEAT NEURONAL 6A (Homo sapiens)	5 / 12	VAL A 341 LEU A 327 PHE A 350 PHE A 316 VAL A 315	None	1.16A	21.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	6DRZ_A_H8JA1206_0 (5HT2B RECEPTOR, BRIL CHIMERA)	2kom	PARTITIONING DEFECTIVE 3 HOMOLOG (Homo sapiens)	5 / 12	VAL A 540 VAL A 528 LEU A 531 PHE A 473 VAL A 517	None	1.16A	13.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	6DRZ_A_H8JA1206_0 (5HT2B RECEPTOR, BRIL CHIMERA)	2qsc	FAB F425-B4E8, HEAVY CHAIN (Homo sapiens)	5 / 12	VAL H 219 THR H 217 VAL H 223 GLY H 118 VAL H 154	None	1.00A	19.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	6DRZ_A_H8JA1206_0 (5HT2B RECEPTOR, BRIL CHIMERA)	2xra	HK20, HUMAN MONOCLONAL ANTIBODY HEAVY CHAIN (Homo sapiens)	5 / 12	VAL H 207 THR H 205 VAL H 211 GLY H 118 VAL H 152	None	1.01A	17.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	6DRZ_A_H8JA1206_0 (5HT2B RECEPTOR, BRIL CHIMERA)	3go1	FAB 268-D, HEAVY CHAIN (Homo sapiens)	5 / 12	VAL H 207 THR H 205 VAL H 211 GLY H 118 VAL H 152	None	1.00A	18.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	6DRZ_A_H8JA1206_0 (5HT2B RECEPTOR, BRIL CHIMERA)	3iu4	CHP3 FAB HEAVY CHAIN (Homo sapiens; Mus musculus)	5 / 12	VAL H 207 THR H 205 VAL H 211 GLY H 118 VAL H 152	None	1.05A	18.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	6DRZ_A_H8JA1206_0 (5HT2B RECEPTOR, BRIL CHIMERA)	3lqa	HEAVY CHAIN OF ANTI HIV FAB FROM HUMAN 21C ANTIBODY (Homo sapiens)	5 / 12	VAL H 219 THR H 217 VAL H 223 GLY H 130 VAL H 164	None	0.92A	17.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	6DRZ_A_H8JA1206_0 (5HT2B RECEPTOR, BRIL CHIMERA)	3mlw	HUMAN MONOCLONAL ANTI-HIV-1 GP120 V3 ANTIBODY 1006-15D FAB HEAVY CHAIN (Homo sapiens)	5 / 12	VAL H 207 THR H 205 VAL H 211 GLY H 118 VAL H 152	None	1.07A	16.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	6DRZ_A_H8JA1206_0 (5HT2B RECEPTOR, BRIL CHIMERA)	3p30	1281 FAB HEAVY CHAIN (Homo sapiens)	5 / 12	VAL H 207 THR H 205 VAL H 211 GLY H 118 VAL H 152	None	0.96A	20.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	6DRZ_A_H8JA1206_0 (5HT2B RECEPTOR, BRIL CHIMERA)	3pbl	D(3) DOPAMINE RECEPTOR, LYSOZYME CHIMERA (Homo sapiens; Escherichia virus T4)	5 / 12	VAL A 111 THR A 115 PHE A 188 PHE A 346 TYR A 373	ETQ  A1200 (-3.4A) None None ETQ  A1200 ( 4.5A) ETQ  A1200 (-4.4A)	0.75A	29.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	6DRZ_A_H8JA1206_0 (5HT2B RECEPTOR, BRIL CHIMERA)	3pbl	D(3) DOPAMINE RECEPTOR, LYSOZYME CHIMERA (Homo sapiens; Escherichia virus T4)	5 / 12	VAL A 111 THR A 115 PHE A 345 PHE A 346 TYR A 373	ETQ  A1200 (-3.4A) None ETQ  A1200 (-4.4A) ETQ  A1200 ( 4.5A) ETQ  A1200 (-4.4A)	0.70A	29.10
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	6DRZ_A_H8JA1206_0 (5HT2B RECEPTOR, BRIL CHIMERA)	3pds	FUSION PROTEIN BETA-2 ADRENERGIC RECEPTOR/LYSOZYME (Homo sapiens; Escherichia virus T4)	5 / 12	VAL A 114 PHE A 289 PHE A 290 ASN A 293 TYR A 316	ERC  A1201 (-3.8A) ERC  A1201 (-4.5A) ERC  A1201 (-4.8A) ERC  A1201 (-3.5A) None	0.60A	30.15
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	6DRZ_A_H8JA1206_0 (5HT2B RECEPTOR, BRIL CHIMERA)	3pds	FUSION PROTEIN BETA-2 ADRENERGIC RECEPTOR/LYSOZYME (Homo sapiens; Escherichia virus T4)	5 / 12	VAL A 114 THR A 118 PHE A 289 PHE A 290 ASN A 293	ERC  A1201 (-3.8A) None ERC  A1201 (-4.5A) ERC  A1201 (-4.8A) ERC  A1201 (-3.5A)	0.75A	30.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	6DRZ_A_H8JA1206_0 (5HT2B RECEPTOR, BRIL CHIMERA)	3piq	HUMAN MONOCLONAL ANTIBODY 2909 FAB HEAVY CHAIN (Homo sapiens)	5 / 12	VAL H 207 THR H 205 VAL H 211 GLY H 118 VAL H 152	None	1.08A	19.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	6DRZ_A_H8JA1206_0 (5HT2B RECEPTOR, BRIL CHIMERA)	3qhf	HUMAN MONOCLONAL ANTIBODY DEL2D1, FAB HEAVY CHAIN (Homo sapiens)	5 / 12	VAL H 219 THR H 217 VAL H 223 GLY H 118 VAL H 154	None	1.07A	19.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	6DRZ_A_H8JA1206_0 (5HT2B RECEPTOR, BRIL CHIMERA)	3s4y	THIAMIN PYROPHOSPHOKINASE 1 (Homo sapiens)	5 / 12	VAL A  22 LEU A 105 GLY A  48 PHE A  67 ASN A  69	None	1.11A	20.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	6DRZ_A_H8JA1206_0 (5HT2B RECEPTOR, BRIL CHIMERA)	3sdy	ANTIBODY CR8020, HEAVY CHAIN (Homo sapiens)	5 / 12	VAL H 207 THR H 205 VAL H 211 GLY H 118 VAL H 152	None	1.09A	19.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	6DRZ_A_H8JA1206_0 (5HT2B RECEPTOR, BRIL CHIMERA)	3ulv	FAB12 HEAVY CHAIN (Homo sapiens)	5 / 12	VAL D 216 THR D 214 VAL D 220 GLY D 127 VAL D 161	None	0.99A	19.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	6DRZ_A_H8JA1206_0 (5HT2B RECEPTOR, BRIL CHIMERA)	3whe	IMMUNOGLOBULIN HEAVY CHAIN (Homo sapiens)	5 / 12	VAL M 220 THR M 218 VAL M 224 GLY M 131 VAL M 165	None	1.08A	16.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	6DRZ_A_H8JA1206_0 (5HT2B RECEPTOR, BRIL CHIMERA)	4a6e	HYDROXYINDOLE O-METHYLTRANSFERASE (Homo sapiens)	5 / 12	LEU A 142 PHE A 143 GLY A 187 PHE A 238 PHE A 237	None SAM  A1349 (-3.8A) SAM  A1349 (-3.6A) SAM  A1349 (-4.7A) SAM  A1349 (-3.5A)	1.12A	20.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	6DRZ_A_H8JA1206_0 (5HT2B RECEPTOR, BRIL CHIMERA)	4d1e	ALPHA-ACTININ-2 (Homo sapiens)	5 / 12	VAL A 614 LEU A 565 PHE A 561 GLY A 534 PHE A 528	None MLZ  A 562 ( 4.2A) MLZ  A 562 ( 4.5A) None None	1.12A	18.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	6DRZ_A_H8JA1206_0 (5HT2B RECEPTOR, BRIL CHIMERA)	4fqk	ANTIBODY CR8059 HEAVY CHAIN (Homo sapiens)	5 / 12	VAL E 207 THR E 205 VAL E 211 GLY E 118 VAL E 152	None	1.01A	18.03
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	6DRZ_A_H8JA1206_0 (5HT2B RECEPTOR, BRIL CHIMERA)	4gbr	BETA-2 ADRENERGIC RECEPTOR (Homo sapiens)	6 / 12	VAL A 114 THR A 118 PHE A 261 PHE A 262 ASN A 265 TYR A 288	CAU  A 500 (-3.5A) CAU  A 500 ( 4.7A) CAU  A 500 (-4.2A) CAU  A 500 (-4.6A) CAU  A 500 (-3.4A) CAU  A 500 (-4.6A)	0.79A	30.12
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	6DRZ_A_H8JA1206_0 (5HT2B RECEPTOR, BRIL CHIMERA)	4ib4	CHIMERA PROTEIN OF HUMAN 5-HYDROXYTRYPTAMINE RECEPTOR 2B AND E. COLI SOLUBLE CYTOCHROME B562 (Escherichia coli; Homo sapiens)	5 / 12	VAL A 136 SER A 139 LEU A 209 PHE A 217 PHE A 340	ERM  A2001 (-3.8A) ERM  A2001 (-3.6A) ERM  A2001 (-3.7A) ERM  A2001 (-4.6A) ERM  A2001 (-4.3A)	1.12A	99.51
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	6DRZ_A_H8JA1206_0 (5HT2B RECEPTOR, BRIL CHIMERA)	4ib4	CHIMERA PROTEIN OF HUMAN 5-HYDROXYTRYPTAMINE RECEPTOR 2B AND E. COLI SOLUBLE CYTOCHROME B562 (Escherichia coli; Homo sapiens)	11 / 12	VAL A 136 SER A 139 THR A 140 VAL A 208 LEU A 209 PHE A 217 PHE A 340 PHE A 341 ASN A 344 VAL A 366 TYR A 370	ERM  A2001 (-3.8A) ERM  A2001 (-3.6A) ERM  A2001 (-3.9A) ERM  A2001 (-4.0A) ERM  A2001 (-3.7A) ERM  A2001 (-4.6A) ERM  A2001 (-4.3A) None ERM  A2001 (-4.3A) ERM  A2001 ( 4.2A) ERM  A2001 ( 4.8A)	0.55A	99.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	6DRZ_A_H8JA1206_0 (5HT2B RECEPTOR, BRIL CHIMERA)	4iml	CROSSED LIGHT CHAIN (VL-CH1) (Homo sapiens)	5 / 12	VAL L 204 THR L 202 VAL L 208 GLY L 115 VAL L 149	None	1.10A	17.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	6DRZ_A_H8JA1206_0 (5HT2B RECEPTOR, BRIL CHIMERA)	4irz	FAB NATALIZUMAB HEAVY CHAIN (Homo sapiens)	5 / 12	VAL H 217 THR H 215 VAL H 221 GLY H 128 VAL H 162	None	1.06A	17.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	6DRZ_A_H8JA1206_0 (5HT2B RECEPTOR, BRIL CHIMERA)	4jb9	ANTIBODY VRC06 HEAVY CHAIN (Homo sapiens)	5 / 12	VAL H 207 THR H 205 VAL H 211 GLY H 118 VAL H 152	None	0.89A	17.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	6DRZ_A_H8JA1206_0 (5HT2B RECEPTOR, BRIL CHIMERA)	4jpw	HEAVY CHAIN OF ANTIBODY 12A21 (Homo sapiens)	5 / 12	VAL H 207 THR H 205 VAL H 211 GLY H 118 VAL H 152	None	1.03A	18.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	6DRZ_A_H8JA1206_0 (5HT2B RECEPTOR, BRIL CHIMERA)	4lde	LYSOZYME, BETA-2 ADRENERGIC RECEPTOR (Homo sapiens; Escherichia virus T4)	6 / 12	VAL A1114 THR A1118 PHE A1289 PHE A1290 ASN A1293 TYR A1316	P0G  A1401 (-3.7A) None P0G  A1401 ( 4.7A) P0G  A1401 ( 4.9A) P0G  A1401 (-3.0A) None	0.39A	25.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	6DRZ_A_H8JA1206_0 (5HT2B RECEPTOR, BRIL CHIMERA)	4mwf	FAB AR3C HEAVY CHAIN (Homo sapiens)	5 / 12	VAL A 207 THR A 205 VAL A 211 GLY A 118 VAL A 152	None	1.04A	19.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	6DRZ_A_H8JA1206_0 (5HT2B RECEPTOR, BRIL CHIMERA)	4od1	CAP256-VRC26.03 HEAVY CHAIN (Homo sapiens)	5 / 12	VAL H 207 THR H 205 VAL H 211 GLY H 118 VAL H 152	None	1.04A	19.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	6DRZ_A_H8JA1206_0 (5HT2B RECEPTOR, BRIL CHIMERA)	4rnr	PGT130 HEAVY CHAIN (Homo sapiens)	5 / 12	VAL A 207 THR A 205 VAL A 211 GLY A 118 VAL A 152	None	1.00A	17.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	6DRZ_A_H8JA1206_0 (5HT2B RECEPTOR, BRIL CHIMERA)	5alc	ANTI-TICAGRELOR FAB 72, HEAVY CHAIN (Homo sapiens)	5 / 12	VAL H 207 THR H 205 VAL H 211 GLY H 118 VAL H 152	None	1.05A	16.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	6DRZ_A_H8JA1206_0 (5HT2B RECEPTOR, BRIL CHIMERA)	5bzd	5G8 HIV ANTIBODY HEAVY CHAIN (Homo sapiens)	5 / 12	VAL B 207 THR B 205 VAL B 211 GLY B 118 VAL B 152	None	1.10A	17.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	6DRZ_A_H8JA1206_0 (5HT2B RECEPTOR, BRIL CHIMERA)	5d1z	D4-10 HEAVY CHAIN (Homo sapiens)	5 / 12	VAL D 222 THR D 220 VAL D 226 GLY D 133 VAL D 167	None	0.97A	18.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	6DRZ_A_H8JA1206_0 (5HT2B RECEPTOR, BRIL CHIMERA)	5drz	HIV ANTIBODY F240 HEAVY CHAIN (Homo sapiens)	5 / 12	VAL H 207 THR H 205 VAL H 211 GLY H 118 VAL H 152	None	1.07A	17.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	6DRZ_A_H8JA1206_0 (5HT2B RECEPTOR, BRIL CHIMERA)	5esv	CH03 HEAVY CHAIN (Homo sapiens)	5 / 12	VAL A 207 THR A 205 VAL A 211 GLY A 118 VAL A 152	None	1.08A	19.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	6DRZ_A_H8JA1206_0 (5HT2B RECEPTOR, BRIL CHIMERA)	5k1c	UBIQUITIN CARBOXYL-TERMINAL HYDROLASE 12 (Homo sapiens)	5 / 12	THR A 135 LEU A  54 PHE A 128 PHE A  63 VAL A  67	None	1.13A	21.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	6DRZ_A_H8JA1206_0 (5HT2B RECEPTOR, BRIL CHIMERA)	5kan	16.G.07 HEAVY CHAIN (Homo sapiens)	5 / 12	VAL G 222 THR G 220 VAL G 226 GLY G 133 VAL G 167	None	0.99A	16.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	6DRZ_A_H8JA1206_0 (5HT2B RECEPTOR, BRIL CHIMERA)	5kaq	ANTIBODY 31.A.83 FAB HEAVY CHAIN (Homo sapiens)	5 / 12	VAL F 225 THR F 223 VAL F 229 GLY F 136 VAL F 170	None	0.94A	18.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	6DRZ_A_H8JA1206_0 (5HT2B RECEPTOR, BRIL CHIMERA)	5lug	SPINDLIN-LIKE PROTEIN 2, ISOFORM CRA_A (Homo sapiens)	5 / 12	VAL A 255 LEU A 254 PHE A 264 GLY A 211 VAL A 232	None	1.10A	19.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	6DRZ_A_H8JA1206_0 (5HT2B RECEPTOR, BRIL CHIMERA)	5nyx	HEAVY CHAIN (Homo sapiens)	5 / 12	VAL H 217 THR H 215 VAL H 221 GLY H 128 VAL H 162	None	1.07A	undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	6DRZ_A_H8JA1206_0 (5HT2B RECEPTOR, BRIL CHIMERA)	5t3x	IOMA HEAVY CHAIN (Homo sapiens)	5 / 12	VAL D 207 THR D 205 VAL D 211 GLY D 118 VAL D 152	None	1.01A	18.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	6DRZ_A_H8JA1206_0 (5HT2B RECEPTOR, BRIL CHIMERA)	5tqa	DH270.6 FAB HEAVY CHAIN (Homo sapiens)	5 / 12	VAL H 221 THR H 219 VAL H 225 GLY H 132 VAL H 166	None	1.10A	17.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	6DRZ_A_H8JA1206_0 (5HT2B RECEPTOR, BRIL CHIMERA)	5vic	FAB HEAVY CHAIN (Homo sapiens)	5 / 12	VAL H 207 THR H 205 VAL H 211 GLY H 118 VAL H 152	None	1.09A	18.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	6DRZ_A_H8JA1206_0 (5HT2B RECEPTOR, BRIL CHIMERA)	5w1k	CR1-10 FAB HEAVY CHAIN (Homo sapiens)	5 / 12	VAL D 220 THR D 218 VAL D 224 GLY D 131 VAL D 165	None	1.02A	undetectable
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	6DRZ_A_H8JA1206_0 (5HT2B RECEPTOR, BRIL CHIMERA)	5wiv	D(4) DOPAMINE RECEPTOR, SOLUBLE CYTOCHROME B562 CHIMERA (Escherichia coli; Homo sapiens)	6 / 12	VAL A 116 THR A 120 LEU A 187 PHE A 410 PHE A 411 TYR A 438	AQD  A1201 ( 3.9A) AQD  A1201 (-4.4A) AQD  A1201 (-4.5A) AQD  A1201 (-4.7A) AQD  A1201 (-4.6A) None	0.76A	50.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	6DRZ_A_H8JA1206_0 (5HT2B RECEPTOR, BRIL CHIMERA)	6apd	AM22 FAB HEAVY CHAIN,IGH@ PROTEIN (Homo sapiens)	5 / 12	VAL D 207 THR D 205 VAL D 211 GLY D 118 VAL D 152	None	1.02A	undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	6DRZ_A_H8JA1206_0 (5HT2B RECEPTOR, BRIL CHIMERA)	6bqh	5-HYDROXYTRYPTAMINE RECEPTOR 2C,SOLUBLE CYTOCHROME B562 (Escherichia coli; Homo sapiens)	6 / 12	SER A 138 PHE A 327 PHE A 328 ASN A 331 VAL A 354 TYR A 358	E2J  A1201 (-3.2A) E2J  A1201 (-4.6A) E2J  A1201 (-4.4A) None E2J  A1201 (-4.6A) None	0.62A	undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	6DRZ_A_H8JA1206_0 (5HT2B RECEPTOR, BRIL CHIMERA)	6bqh	5-HYDROXYTRYPTAMINE RECEPTOR 2C,SOLUBLE CYTOCHROME B562 (Escherichia coli; Homo sapiens)	8 / 12	VAL A 135 SER A 138 THR A 139 LEU A 209 PHE A 327 PHE A 328 VAL A 354 TYR A 358	E2J  A1201 (-3.8A) E2J  A1201 (-3.2A) E2J  A1201 (-4.3A) None E2J  A1201 (-4.6A) E2J  A1201 (-4.4A) E2J  A1201 (-4.6A) None	0.84A	undetectable
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	6DRZ_A_H8JA1206_0 (5HT2B RECEPTOR, BRIL CHIMERA)	6cm4	D(2) DOPAMINE RECEPTOR, ENDOLYSIN CHIMERA (Homo sapiens; Escherichia virus T4)	5 / 12	VAL A 115 THR A 119 PHE A 389 PHE A 390 TYR A 416	8NU  A2001 ( 3.5A) 8NU  A2001 ( 4.4A) 8NU  A2001 ( 4.5A) 8NU  A2001 ( 4.8A) 8NU  A2001 ( 4.9A)	0.79A	33.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	6DRZ_A_H8JA1206_0 (5HT2B RECEPTOR, BRIL CHIMERA)	6db6	HUMAN MONOCLONAL ANTI-HIV-1 GP120 V3 ANTIBODY 311-11D FAB HEAVY CHAIN (Homo sapiens)	5 / 12	VAL H 207 THR H 205 VAL H 211 GLY H 118 VAL H 152	None	1.06A	undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	6DRZ_A_H8JA1206_0 (5HT2B RECEPTOR, BRIL CHIMERA)	6db7	HUMAN MONOCLONAL ANTI-HIV-1 GP120 V3 ANTIBODY 1334 FAB HEAVY CHAIN (Homo sapiens)	5 / 12	VAL H 207 THR H 205 VAL H 211 GLY H 118 VAL H 152	None	1.07A	undetectable