POTENTIAL TARGETS FROM HUMAN (RESULTS FROM SUB-STRUCTURAL SIMILARITY SEARCHES)
1) User may click on the DrReposER ID (the second column) to get information on the binding sites and drug molecule.
2) Click View (the second last column) to view matched residues and superposition in the NGL viewer (upper right part).
3) User may also click on the Dock (the last column) to get script for molecular docking in UCSF Chimera through AutoDock Vina.

DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DRX_A_H8GA1201_0
(5HT2B RECEPTOR, BRIL
CHIMERA)		1ey2 HOMOGENTISATE
1,2-DIOXYGENASE
(Homo
sapiens)		5 / 12VAL A  81
THR A 118
ALA A 132
PHE A 154
ASN A 149
None
1.25A19.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DRX_A_H8GA1201_0
(5HT2B RECEPTOR, BRIL
CHIMERA)		1kqo NICOTINAMIDE
MONONUCLEOTIDE
ADENYLYL TRANSFERASE
(Homo
sapiens)		5 / 12LEU A  11
VAL A  80
THR A  74
ALA A  73
PHE A  17
None
None
None
None
DND  A 301 (-4.6A)
1.46A21.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DRX_A_H8GA1201_0
(5HT2B RECEPTOR, BRIL
CHIMERA)		1x5r GLUTAMATE RECEPTOR
INTERACTING PROTEIN
2
(Homo
sapiens)		5 / 12VAL A  70
SER A  72
THR A  78
ALA A  86
VAL A 100
None
1.33A14.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DRX_A_H8GA1201_0
(5HT2B RECEPTOR, BRIL
CHIMERA)		2adu METHIONINE
AMINOPEPTIDASE 2
(Homo
sapiens)		5 / 12SER A 473
THR A 461
PHE A 219
ALA A 362
TYR A 478
None
None
R20  A 906 ( 3.8A)
CO  A 502 ( 3.8A)
None
1.46A21.61
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
6DRX_A_H8GA1201_0
(5HT2B RECEPTOR, BRIL
CHIMERA)		3pds FUSION PROTEIN
BETA-2 ADRENERGIC
RECEPTOR/LYSOZYME
(Homo
sapiens;
Escherichia
virus
T4)		6 / 12TRP A 109
VAL A 114
THR A 118
TRP A 286
PHE A 289
ASN A 293
None
ERC  A1201 (-3.8A)
None
None
ERC  A1201 (-4.5A)
ERC  A1201 (-3.5A)
0.93A30.35
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
6DRX_A_H8GA1201_0
(5HT2B RECEPTOR, BRIL
CHIMERA)		3pds FUSION PROTEIN
BETA-2 ADRENERGIC
RECEPTOR/LYSOZYME
(Homo
sapiens;
Escherichia
virus
T4)		6 / 12TRP A 109
VAL A 114
TRP A 286
PHE A 289
ASN A 293
TYR A 316
None
ERC  A1201 (-3.8A)
None
ERC  A1201 (-4.5A)
ERC  A1201 (-3.5A)
None
0.82A30.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DRX_A_H8GA1201_0
(5HT2B RECEPTOR, BRIL
CHIMERA)		3rze HISTAMINE H1
RECEPTOR, LYSOZYME
CHIMERA
(Homo
sapiens;
Escherichia
virus
T4)		6 / 12TRP A 103
LEU A 104
SER A 111
THR A 112
TRP A 428
TYR A 458
None
None
5EH  A1200 ( 3.7A)
D7V  A1201 ( 4.0A)
5EH  A1200 ( 3.4A)
5EH  A1200 ( 4.4A)
0.79A27.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DRX_A_H8GA1201_0
(5HT2B RECEPTOR, BRIL
CHIMERA)		3uon HUMAN M2 MUSCARINIC
ACETYLCHOLINE,
RECEPTOR T4 LYSOZYME
FUSION PROTEIN
(Homo
sapiens;
Escherichia
virus
T4)		5 / 12TRP A  99
LEU A 100
SER A 107
PHE A 181
ALA A 194
None
None
QNB  A1162 (-3.4A)
QNB  A1162 (-4.4A)
QNB  A1162 ( 4.0A)
0.99A27.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DRX_A_H8GA1201_0
(5HT2B RECEPTOR, BRIL
CHIMERA)		3uon HUMAN M2 MUSCARINIC
ACETYLCHOLINE,
RECEPTOR T4 LYSOZYME
FUSION PROTEIN
(Homo
sapiens;
Escherichia
virus
T4)		5 / 12TRP A  99
LEU A 100
SER A 107
PHE A 181
TRP A 400
None
None
QNB  A1162 (-3.4A)
QNB  A1162 (-4.4A)
QNB  A1162 (-4.7A)
1.31A27.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DRX_A_H8GA1201_0
(5HT2B RECEPTOR, BRIL
CHIMERA)		4fys AMINOPEPTIDASE N
(Homo
sapiens)		5 / 12LEU A 325
ALA A 414
ASN A 397
VAL A 360
TYR A 362
None
1.39A17.38
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
6DRX_A_H8GA1201_0
(5HT2B RECEPTOR, BRIL
CHIMERA)		4gbr BETA-2 ADRENERGIC
RECEPTOR
(Homo
sapiens)		7 / 12TRP A 109
VAL A 114
THR A 118
TRP A 258
PHE A 261
ASN A 265
TYR A 288
None
CAU  A 500 (-3.5A)
CAU  A 500 ( 4.7A)
None
CAU  A 500 (-4.2A)
CAU  A 500 (-3.4A)
CAU  A 500 (-4.6A)
0.93A30.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DRX_A_H8GA1201_0
(5HT2B RECEPTOR, BRIL
CHIMERA)		4hq6 ACETYL-COA
CARBOXYLASE 2
(Homo
sapiens)		5 / 12TRP A 351
SER A 685
THR A 668
ALA A 308
TYR A 683
None
1.41A21.07
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
6DRX_A_H8GA1201_0
(5HT2B RECEPTOR, BRIL
CHIMERA)		4ib4 CHIMERA PROTEIN OF
HUMAN
5-HYDROXYTRYPTAMINE
RECEPTOR 2B AND E.
COLI SOLUBLE
CYTOCHROME B562
(Escherichia
coli;
Homo
sapiens)		12 / 12TRP A 131
LEU A 132
VAL A 136
SER A 139
THR A 140
PHE A 217
ALA A 225
TRP A 337
PHE A 340
ASN A 344
VAL A 366
TYR A 370
None
None
ERM  A2001 (-3.8A)
ERM  A2001 (-3.6A)
ERM  A2001 (-3.9A)
ERM  A2001 (-4.6A)
ERM  A2001 (-3.4A)
None
ERM  A2001 (-4.3A)
ERM  A2001 (-4.3A)
ERM  A2001 ( 4.2A)
ERM  A2001 ( 4.8A)
0.38A100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
6DRX_A_H8GA1201_0
(5HT2B RECEPTOR, BRIL
CHIMERA)		4ib4 CHIMERA PROTEIN OF
HUMAN
5-HYDROXYTRYPTAMINE
RECEPTOR 2B AND E.
COLI SOLUBLE
CYTOCHROME B562
(Escherichia
coli;
Homo
sapiens)		5 / 12VAL A 136
SER A 139
PHE A 217
TRP A 337
PHE A 341
ERM  A2001 (-3.8A)
ERM  A2001 (-3.6A)
ERM  A2001 (-4.6A)
None
None
1.45A100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DRX_A_H8GA1201_0
(5HT2B RECEPTOR, BRIL
CHIMERA)		4lde LYSOZYME, BETA-2
ADRENERGIC RECEPTOR
(Homo
sapiens;
Escherichia
virus
T4)		7 / 12TRP A1109
VAL A1114
THR A1118
TRP A1286
PHE A1289
ASN A1293
TYR A1316
None
P0G  A1401 (-3.7A)
None
None
P0G  A1401 ( 4.7A)
P0G  A1401 (-3.0A)
None
0.53A25.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DRX_A_H8GA1201_0
(5HT2B RECEPTOR, BRIL
CHIMERA)		4mqt MUSCARINIC
ACETYLCHOLINE
RECEPTOR M2
(Homo
sapiens)		5 / 12TRP A  99
LEU A 100
SER A 107
ALA A 194
TRP A 400
None
None
IXO  A 501 (-3.4A)
IXO  A 501 (-3.5A)
IXO  A 501 (-4.6A)
0.60A27.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DRX_A_H8GA1201_0
(5HT2B RECEPTOR, BRIL
CHIMERA)		4mqt MUSCARINIC
ACETYLCHOLINE
RECEPTOR M2
(Homo
sapiens)		5 / 12TRP A  99
LEU A 100
SER A 107
ALA A 194
TYR A 430
None
None
IXO  A 501 (-3.4A)
IXO  A 501 (-3.5A)
IXO  A 501 (-4.5A)
0.76A27.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DRX_A_H8GA1201_0
(5HT2B RECEPTOR, BRIL
CHIMERA)		4pju COHESIN SUBUNIT SA-2
DOUBLE-STRAND-BREAK
REPAIR PROTEIN RAD21
HOMOLOG
(Homo
sapiens;
Homo
sapiens)		5 / 12VAL A 376
SER A 377
THR A 379
ALA A 390
TYR B 344
None
1.32A18.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DRX_A_H8GA1201_0
(5HT2B RECEPTOR, BRIL
CHIMERA)		5dsg MUSCARINIC
ACETYLCHOLINE
RECEPTOR
M4,ENDOLYSIN,ENDOLYS
IN,MUSCARINIC
ACETYLCHOLINE
RECEPTOR M4
(Homo
sapiens;
Escherichia
virus
T4)		5 / 12TRP A 108
LEU A 109
SER A 116
ALA A 203
TRP A 413
None
P6G  A1205 (-4.7A)
0HK  A1201 (-3.3A)
0HK  A1201 (-3.6A)
0HK  A1201 (-4.3A)
1.22A29.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DRX_A_H8GA1201_0
(5HT2B RECEPTOR, BRIL
CHIMERA)		5v54 5-HYDROXYTRYPTAMINE
RECEPTOR 1B,OB-1
FUSED 5-HT1B
RECEPTOR,5-HYDROXYTR
YPTAMINE RECEPTOR 1B
(Spodoptera
frugiperda;
Homo
sapiens)		5 / 12LEU A 126
THR A 134
ALA A 216
PHE A 330
TYR A 359
89F  A1201 (-4.9A)
89F  A1201 (-4.2A)
89F  A1201 ( 3.9A)
89F  A1201 (-4.1A)
None
0.97Aundetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DRX_A_H8GA1201_0
(5HT2B RECEPTOR, BRIL
CHIMERA)		5v54 5-HYDROXYTRYPTAMINE
RECEPTOR 1B,OB-1
FUSED 5-HT1B
RECEPTOR,5-HYDROXYTR
YPTAMINE RECEPTOR 1B
(Spodoptera
frugiperda;
Homo
sapiens)		5 / 12THR A 134
ALA A 216
TRP A 327
PHE A 330
TYR A 359
89F  A1201 (-4.2A)
89F  A1201 ( 3.9A)
89F  A1201 (-3.6A)
89F  A1201 (-4.1A)
None
0.77Aundetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DRX_A_H8GA1201_0
(5HT2B RECEPTOR, BRIL
CHIMERA)		5v54 5-HYDROXYTRYPTAMINE
RECEPTOR 1B,OB-1
FUSED 5-HT1B
RECEPTOR,5-HYDROXYTR
YPTAMINE RECEPTOR 1B
(Spodoptera
frugiperda;
Homo
sapiens)		5 / 12TRP A 125
LEU A 126
THR A 134
ALA A 216
PHE A 330
None
89F  A1201 (-4.9A)
89F  A1201 (-4.2A)
89F  A1201 ( 3.9A)
89F  A1201 (-4.1A)
0.96Aundetectable
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
6DRX_A_H8GA1201_0
(5HT2B RECEPTOR, BRIL
CHIMERA)		5wiv D(4) DOPAMINE
RECEPTOR, SOLUBLE
CYTOCHROME B562
CHIMERA
(Escherichia
coli;
Homo
sapiens)		5 / 12VAL A 116
THR A 120
TRP A 407
PHE A 410
TYR A 438
AQD  A1201 ( 3.9A)
AQD  A1201 (-4.4A)
None
AQD  A1201 (-4.7A)
None
0.73A51.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DRX_A_H8GA1201_0
(5HT2B RECEPTOR, BRIL
CHIMERA)		5xjv DUAL SPECIFICITY
PROTEIN PHOSPHATASE
13 ISOFORM A
(Homo
sapiens)		5 / 12VAL A  88
SER A  87
THR A  65
ALA A 123
PHE A 113
None
1.41Aundetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DRX_A_H8GA1201_0
(5HT2B RECEPTOR, BRIL
CHIMERA)		6bqh 5-HYDROXYTRYPTAMINE
RECEPTOR 2C,SOLUBLE
CYTOCHROME B562
(Escherichia
coli;
Homo
sapiens)		5 / 12LEU A 209
SER A 138
TRP A 324
VAL A 354
TYR A 358
None
E2J  A1201 (-3.2A)
E2J  A1201 ( 3.7A)
E2J  A1201 (-4.6A)
None
1.48Aundetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DRX_A_H8GA1201_0
(5HT2B RECEPTOR, BRIL
CHIMERA)		6bqh 5-HYDROXYTRYPTAMINE
RECEPTOR 2C,SOLUBLE
CYTOCHROME B562
(Escherichia
coli;
Homo
sapiens)		7 / 12TRP A 130
SER A 138
THR A 139
TRP A 324
PHE A 327
VAL A 354
TYR A 358
None
E2J  A1201 (-3.2A)
E2J  A1201 (-4.3A)
E2J  A1201 ( 3.7A)
E2J  A1201 (-4.6A)
E2J  A1201 (-4.6A)
None
0.74Aundetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DRX_A_H8GA1201_0
(5HT2B RECEPTOR, BRIL
CHIMERA)		6bqh 5-HYDROXYTRYPTAMINE
RECEPTOR 2C,SOLUBLE
CYTOCHROME B562
(Escherichia
coli;
Homo
sapiens)		7 / 12TRP A 130
SER A 138
TRP A 324
PHE A 327
ASN A 331
VAL A 354
TYR A 358
None
E2J  A1201 (-3.2A)
E2J  A1201 ( 3.7A)
E2J  A1201 (-4.6A)
None
E2J  A1201 (-4.6A)
None
0.63Aundetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DRX_A_H8GA1201_0
(5HT2B RECEPTOR, BRIL
CHIMERA)		6bqh 5-HYDROXYTRYPTAMINE
RECEPTOR 2C,SOLUBLE
CYTOCHROME B562
(Escherichia
coli;
Homo
sapiens)		7 / 12TRP A 130
VAL A 135
SER A 138
THR A 139
ALA A 222
TRP A 324
TYR A 358
None
E2J  A1201 (-3.8A)
E2J  A1201 (-3.2A)
E2J  A1201 (-4.3A)
E2J  A1201 ( 3.8A)
E2J  A1201 ( 3.7A)
None
0.64Aundetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DRX_A_H8GA1201_0
(5HT2B RECEPTOR, BRIL
CHIMERA)		6bqh 5-HYDROXYTRYPTAMINE
RECEPTOR 2C,SOLUBLE
CYTOCHROME B562
(Escherichia
coli;
Homo
sapiens)		7 / 12TRP A 130
VAL A 135
SER A 138
THR A 139
TRP A 324
PHE A 327
TYR A 358
None
E2J  A1201 (-3.8A)
E2J  A1201 (-3.2A)
E2J  A1201 (-4.3A)
E2J  A1201 ( 3.7A)
E2J  A1201 (-4.6A)
None
0.70Aundetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DRX_A_H8GA1201_0
(5HT2B RECEPTOR, BRIL
CHIMERA)		6g79 5-HYDROXYTRYPTAMINE
RECEPTOR 1B
(Homo
sapiens)		6 / 12LEU S 126
THR S 134
ALA S 216
TRP S 327
PHE S 330
TYR S 359
None
EP5  S 401 (-3.8A)
EP5  S 401 ( 4.0A)
None
EP5  S 401 (-4.0A)
EP5  S 401 ( 4.9A)
0.60Aundetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DRX_A_H8GA1201_0
(5HT2B RECEPTOR, BRIL
CHIMERA)		6g79 5-HYDROXYTRYPTAMINE
RECEPTOR 1B
(Homo
sapiens)		6 / 12TRP S 125
LEU S 126
THR S 134
ALA S 216
TRP S 327
TYR S 359
None
None
EP5  S 401 (-3.8A)
EP5  S 401 ( 4.0A)
None
EP5  S 401 ( 4.9A)
0.58Aundetectable