POTENTIAL TARGETS FROM HUMAN (RESULTS FROM SUB-STRUCTURAL SIMILARITY SEARCHES)1) User may click on the DrReposER ID (the second column) to get information on the binding sites and drug molecule.
2) Click View (the second last column) to view matched residues and superposition in the NGL viewer (upper right part).
3) User may also click on the Dock (the last column) to get script for molecular docking in UCSF Chimera through AutoDock Vina.

	DrReposER ID / Desc.	Hit PDBID	Hit Macromolecule	Res. Matches	Interface	HETATM	RMSD	Seq. Identity (%)	View	Dock
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	4C66_A_H4CA1168_0 (BROMODOMAIN-CONTAINI NG PROTEIN 4)	2dvr	BROMODOMAIN-CONTAINI NG PROTEIN 2 (Homo sapiens)	9 / 9	TRP A  31 PRO A  32 GLN A  35 VAL A  37 LEU A  42 LEU A  44 ASN A  90 ILE A  96 MET A  99	None	0.42A	64.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4C66_A_H4CA1168_0 (BROMODOMAIN-CONTAINI NG PROTEIN 4)	2lav	VACCINIA-RELATED KINASE 1 (Homo sapiens)	5 / 9	PRO A 296 LEU A 155 LEU A 324 ILE A 299 MET A 286	None	1.48A	16.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	4C66_A_H4CA1168_0 (BROMODOMAIN-CONTAINI NG PROTEIN 4)	2yek	BROMODOMAIN-CONTAINI NG PROTEIN 2 (Homo sapiens)	8 / 9	TRP A  97 PRO A  98 VAL A 103 LEU A 108 LEU A 110 ASN A 156 ILE A 162 MET A 165	None EAM  A1188 (-4.6A) EAM  A1188 (-4.4A) EAM  A1188 ( 3.8A) EAM  A1188 (-4.5A) EAM  A1188 (-3.2A) EAM  A1188 (-3.8A) EAM  A1188 ( 4.1A)	0.47A	69.85
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	4C66_A_H4CA1168_0 (BROMODOMAIN-CONTAINI NG PROTEIN 4)	2yek	BROMODOMAIN-CONTAINI NG PROTEIN 2 (Homo sapiens)	5 / 9	VAL A 103 LEU A 108 ASN A 156 ILE A 162 MET A 165	EAM  A1188 (-4.4A) EAM  A1188 ( 3.8A) EAM  A1188 (-3.2A) EAM  A1188 (-3.8A) EAM  A1188 ( 4.1A)	1.43A	69.85
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	4C66_A_H4CA1168_0 (BROMODOMAIN-CONTAINI NG PROTEIN 4)	3nxb	CAT EYE SYNDROME CRITICAL REGION PROTEIN 2 (Homo sapiens)	5 / 9	TRP A 457 PRO A 458 VAL A 463 ASN A 514 MET A 523	None None EDO  A   1 (-4.3A) EDO  A   1 (-3.3A) None	0.57A	32.56
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	4C66_A_H4CA1168_0 (BROMODOMAIN-CONTAINI NG PROTEIN 4)	4hbx	BROMODOMAIN-CONTAINI NG PROTEIN 4 (Homo sapiens)	9 / 9	TRP A  81 PRO A  82 GLN A  85 VAL A  87 LEU A  92 LEU A  94 ASN A 140 ILE A 146 MET A 149	None 14X  A 201 (-4.4A) None 14X  A 201 (-4.7A) 14X  A 201 (-4.4A) None 14X  A 201 (-3.1A) 14X  A 201 ( 4.0A) 14X  A 201 (-3.5A)	0.57A	100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4C66_A_H4CA1168_0 (BROMODOMAIN-CONTAINI NG PROTEIN 4)	4n3w	CREB-BINDING PROTEIN (Homo sapiens)	5 / 9	PRO A1110 GLN A1113 VAL A1115 LEU A1120 ASN A1168	None	0.66A	20.42
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	4C66_A_H4CA1168_0 (BROMODOMAIN-CONTAINI NG PROTEIN 4)	4uyd	BROMODOMAIN-CONTAINI NG PROTEIN 4 (Homo sapiens)	9 / 9	TRP A  81 PRO A  82 GLN A  85 VAL A  87 LEU A  92 LEU A  94 ASN A 140 ILE A 146 MET A 149	None V1T  A1171 (-4.2A) V1T  A1171 (-4.6A) V1T  A1171 (-4.9A) V1T  A1171 (-3.8A) None V1T  A1171 (-3.1A) DMS  A1169 ( 4.3A) DMS  A1169 ( 3.8A)	0.35A	92.65
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	4C66_A_H4CA1168_0 (BROMODOMAIN-CONTAINI NG PROTEIN 4)	4uyg	BROMODOMAIN-CONTAINI NG PROTEIN 2 (Homo sapiens)	7 / 9	TRP A 370 PRO A 371 VAL A 376 LEU A 381 LEU A 383 ASN A 429 MET A 438	None None 73B  A1456 (-4.0A) 73B  A1456 (-4.9A) 73B  A1456 (-4.9A) 73B  A1456 (-3.3A) 73B  A1456 ( 3.8A)	0.43A	35.06
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	4C66_A_H4CA1168_0 (BROMODOMAIN-CONTAINI NG PROTEIN 4)	4z93	BROMODOMAIN-CONTAINI NG PROTEIN 4 (Homo sapiens)	7 / 9	TRP A 374 PRO A 375 VAL A 380 LEU A 385 LEU A 387 ASN A 433 MET A 442	4LD  A 501 (-3.9A) 4LD  A 501 (-3.9A) 4LD  A 501 ( 3.8A) 4LD  A 501 (-4.1A) 4LD  A 501 (-4.4A) 4LD  A 501 (-2.8A) 4LD  A 501 ( 3.4A)	0.50A	36.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4C66_A_H4CA1168_0 (BROMODOMAIN-CONTAINI NG PROTEIN 4)	5enf	PH-INTERACTING PROTEIN (Homo sapiens)	5 / 9	PRO A1340 GLN A1343 VAL A1345 ILE A1403 MET A1406	None None 5Q7  A1503 (-4.0A) 5Q7  A1503 ( 3.9A) None	0.95A	27.27
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	4C66_A_H4CA1168_0 (BROMODOMAIN-CONTAINI NG PROTEIN 4)	5hjc	BROMODOMAIN-CONTAINI NG PROTEIN 3 (Homo sapiens)	7 / 9	TRP A 332 PRO A 333 VAL A 338 LEU A 343 LEU A 345 ASN A 391 MET A 400	None	0.56A	39.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4C66_A_H4CA1168_0 (BROMODOMAIN-CONTAINI NG PROTEIN 4)	5i8g	CREB-BINDING PROTEIN (Homo sapiens)	5 / 9	PRO A1110 GLN A1113 VAL A1115 LEU A1120 ASN A1168	69E  A1404 (-3.7A) 69E  A1404 (-3.4A) 69E  A1404 (-4.3A) 69E  A1404 (-4.2A) 69E  A1404 (-3.0A)	0.75A	22.32
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	4C66_A_H4CA1168_0 (BROMODOMAIN-CONTAINI NG PROTEIN 4)	5lpk	HISTONE ACETYLTRANSFERASE P300 (Homo sapiens)	5 / 9	PRO A1074 GLN A1077 VAL A1079 LEU A1084 ASN A1132	XDM  A1201 (-3.9A) None XDM  A1201 (-4.7A) XDM  A1201 ( 4.4A) XDM  A1201 (-3.1A)	0.49A	31.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4C66_A_H4CA1168_0 (BROMODOMAIN-CONTAINI NG PROTEIN 4)	5u6v	BROMODOMAIN-CONTAINI NG PROTEIN 2 (Homo sapiens)	7 / 9	TRP A 370 PRO A 371 VAL A 376 LEU A 381 LEU A 383 ASN A 429 MET A 438	None 7WY  A 501 (-4.4A) 7WY  A 501 ( 4.5A) 7WY  A 501 (-4.9A) None 7WY  A 501 (-3.4A) 7WY  A 501 ( 3.9A)	0.40A	undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4C66_A_H4CA1168_0 (BROMODOMAIN-CONTAINI NG PROTEIN 4)	5v84	CAT EYE SYNDROME CRITICAL REGION PROTEIN 2 (Homo sapiens)	5 / 9	TRP A 457 PRO A 458 VAL A 463 ASN A 514 MET A 523	None 96V  A 602 (-4.5A) 96V  A 602 (-3.9A) 96V  A 602 (-2.6A) None	0.29A	28.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4C66_A_H4CA1168_0 (BROMODOMAIN-CONTAINI NG PROTEIN 4)	5vbr	BROMODOMAIN TESTIS-SPECIFIC PROTEIN (Homo sapiens)	8 / 9	TRP A  50 PRO A  51 VAL A  56 LEU A  61 LEU A  63 ASN A 109 ILE A 115 MET A 118	CL  A 208 (-4.9A) IBI  A 201 (-4.3A) IBI  A 201 ( 4.6A) IBI  A 201 (-4.2A) IBI  A 201 (-4.9A) IBI  A 201 (-3.3A) IBI  A 201 ( 3.8A) None	0.50A	undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4C66_A_H4CA1168_0 (BROMODOMAIN-CONTAINI NG PROTEIN 4)	6dne	BROMODOMAIN-CONTAINI NG PROTEIN 4 (Homo sapiens)	9 / 9	TRP A  81 PRO A  82 GLN A  85 VAL A  87 LEU A  92 LEU A  94 ASN A 140 ILE A 146 MET A 149	None H1V  A 501 (-4.6A) H1V  A 501 ( 4.5A) H1V  A 501 ( 4.4A) H1V  A 501 (-4.2A) H1V  A 501 (-4.7A) H1V  A 501 (-3.2A) H1V  A 501 (-3.8A) H1V  A 501 ( 3.8A)	0.52A	undetectable