POTENTIAL TARGETS FROM HUMAN (RESULTS FROM SUB-STRUCTURAL SIMILARITY SEARCHES)
1) User may click on the DrReposER ID (the second column) to get information on the binding sites and drug molecule.
2) Click View (the second last column) to view matched residues and superposition in the NGL viewer (upper right part).
3) User may also click on the Dock (the last column) to get script for molecular docking in UCSF Chimera through AutoDock Vina.


DrReposER ID / Desc. Hit
PDBID
Hit
Macromolecule
Res.
Matches
Interface HETATM RMSD Seq.
Identity (%)
View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ETE_A_H3PA552_1
(GLUTAMATE
DEHYDROGENASE)
1ygu LEUKOCYTE COMMON
ANTIGEN
(Homo
sapiens)
4 / 6ILE A 824
TYR A 687
ILE A 715
HIS A 788
None
1.17A23.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ETE_A_H3PA552_1
(GLUTAMATE
DEHYDROGENASE)
2d5r CCR4-NOT
TRANSCRIPTION
COMPLEX SUBUNIT 7
(Homo
sapiens)
4 / 6ILE A 250
LYS A 152
ILE A 192
HIS A 258
None
1.21A19.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ETE_A_H3PA552_1
(GLUTAMATE
DEHYDROGENASE)
2gf0 GTP-BINDING PROTEIN
DI-RAS1
(Homo
sapiens)
4 / 6ILE A  76
TYR A 101
ILE A 114
HIS A  80
None
0.97A16.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ETE_A_H3PA552_1
(GLUTAMATE
DEHYDROGENASE)
2lns ANTERIOR GRADIENT
PROTEIN 2 HOMOLOG
(Homo
sapiens)
4 / 6ILE A  74
MET A 164
ILE A 128
HIS A  77
None
1.15A15.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ETE_A_H3PA552_1
(GLUTAMATE
DEHYDROGENASE)
2p1f URIDINE
5'-MONOPHOSPHATE
SYNTHASE
(Homo
sapiens)
4 / 6ILE A 250
MET A  58
ILE A 257
HIS A 225
None
1.21A23.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ETE_A_H3PA552_1
(GLUTAMATE
DEHYDROGENASE)
3edi TOLLOID-LIKE PROTEIN
1
(Homo
sapiens)
4 / 6ILE A  77
TYR A  17
MET A  29
HIS A  92
None
DMS  A 215 (-4.3A)
None
ZN  A 210 (-3.2A)
1.07A18.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ETE_A_H3PA552_1
(GLUTAMATE
DEHYDROGENASE)
4cq1 POLYPYRIMIDINE
TRACT-BINDING
PROTEIN 2
(Homo
sapiens)
4 / 6ILE A 380
TYR A 362
MET A 400
ILE A 405
None
1.13A18.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ETE_A_H3PA552_1
(GLUTAMATE
DEHYDROGENASE)
4d61 EUKARYOTIC PEPTIDE
CHAIN RELEASE FACTOR
GTP-BINDING SUBUNIT
ERF3A
(Homo
sapiens)
4 / 6ILE i 526
MET i 334
ILE i 529
HIS i 531
None
1.18A23.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ETE_A_H3PA552_1
(GLUTAMATE
DEHYDROGENASE)
4db1 MYOSIN-7
(Homo
sapiens)
4 / 6ILE A 313
TYR A 283
ILE A 356
HIS A 358
None
0.98A20.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ETE_A_H3PA552_1
(GLUTAMATE
DEHYDROGENASE)
4fmw RNA
(GUANINE-9-)-METHYLT
RANSFERASE
DOMAIN-CONTAINING
PROTEIN 2
(Homo
sapiens)
4 / 6ILE A 227
TYR A 203
LYS A 201
ILE A 178
None
1.19A16.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ETE_A_H3PA552_1
(GLUTAMATE
DEHYDROGENASE)
4gl2 INTERFERON-INDUCED
HELICASE C
DOMAIN-CONTAINING
PROTEIN 1
(Homo
sapiens)
4 / 6ILE A 484
TYR A 454
ILE A 441
HIS A 346
None
1.08A22.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ETE_A_H3PA552_1
(GLUTAMATE
DEHYDROGENASE)
4l87 SERINE--TRNA LIGASE,
CYTOPLASMIC
(Homo
sapiens)
4 / 6ILE A 276
TYR A 224
MET A 229
ILE A 269
None
1.04A21.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ETE_A_H3PA552_1
(GLUTAMATE
DEHYDROGENASE)
4p7h MYOSIN-7,GREEN
FLUORESCENT PROTEIN
(Aequorea
victoria;
Homo
sapiens)
4 / 6ILE A 313
TYR A 283
ILE A 356
HIS A 358
None
0.98A19.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ETE_A_H3PA552_1
(GLUTAMATE
DEHYDROGENASE)
4yhj G PROTEIN-COUPLED
RECEPTOR KINASE 4
(Homo
sapiens)
4 / 6ILE A 380
TYR A 292
ILE A 276
HIS A 383
None
1.21A20.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ETE_A_H3PA552_1
(GLUTAMATE
DEHYDROGENASE)
5ig3 CALCIUM/CALMODULIN-D
EPENDENT PROTEIN
KINASE TYPE II
SUBUNIT ALPHA
(Homo
sapiens)
4 / 6ILE A 350
TYR A 431
ILE A 464
HIS A 456
None
0.81A15.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ETE_A_H3PA552_1
(GLUTAMATE
DEHYDROGENASE)
5kj2 HISTONE
ACETYLTRANSFERASE
P300
(Homo
sapiens)
4 / 6ILE A1479
TYR A1421
ILE A1598
HIS A1481
None
1.22A23.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ETE_A_H3PA552_1
(GLUTAMATE
DEHYDROGENASE)
5lkz HISTONE
ACETYLTRANSFERASE
P300,HISTONE
ACETYLTRANSFERASE
P300
(Homo
sapiens)
4 / 6ILE A1479
TYR A1421
ILE A1598
HIS A1481
None
1.18A22.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ETE_A_H3PA552_1
(GLUTAMATE
DEHYDROGENASE)
5zcs TARGET OF RAPAMYCIN
COMPLEX SUBUNIT LST8
(Homo
sapiens)
4 / 6ILE C 173
MET C 185
ILE C 144
HIS C 153
None
1.03A12.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ETE_B_H3PB552_1
(GLUTAMATE
DEHYDROGENASE)
1jy1 TYROSYL-DNA
PHOSPHODIESTERASE
(Homo
sapiens)
3 / 3TYR A 497
TYR A 574
ILE A 440
None
0.71A21.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ETE_B_H3PB552_1
(GLUTAMATE
DEHYDROGENASE)
1mt6 SET9
(Homo
sapiens)
3 / 3TYR A 245
TYR A 287
ILE A 201
None
0.83A21.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ETE_B_H3PB552_1
(GLUTAMATE
DEHYDROGENASE)
2b5m DAMAGE-SPECIFIC DNA
BINDING PROTEIN 1
(Homo
sapiens)
3 / 3TYR A 171
TYR A 271
ILE A 220
None
0.85A19.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ETE_B_H3PB552_1
(GLUTAMATE
DEHYDROGENASE)
2j67 TOLL LIKE RECEPTOR
10
(Homo
sapiens)
3 / 3TYR A 668
TYR A 708
ILE A 682
None
0.67A18.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ETE_B_H3PB552_1
(GLUTAMATE
DEHYDROGENASE)
2qqh COMPLEMENT COMPONENT
C8 ALPHA CHAIN
(Homo
sapiens)
3 / 3TYR A 422
TYR A 185
ILE A 116
None
0.84A21.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ETE_B_H3PB552_1
(GLUTAMATE
DEHYDROGENASE)
2v40 ADENYLOSUCCINATE
SYNTHETASE ISOZYME 2
(Homo
sapiens)
3 / 3TYR A 300
TYR A 428
ILE A 372
None
0.76A22.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ETE_B_H3PB552_1
(GLUTAMATE
DEHYDROGENASE)
3max HISTONE DEACETYLASE
2
(Homo
sapiens)
3 / 3TYR A 206
TYR A 363
ILE A 367
None
0.70A21.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ETE_B_H3PB552_1
(GLUTAMATE
DEHYDROGENASE)
3q5e ATLASTIN-1
(Homo
sapiens)
3 / 3TYR A 196
TYR A 336
ILE A 335
None
0.74A23.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ETE_B_H3PB552_1
(GLUTAMATE
DEHYDROGENASE)
4pd3 NONMUSCLE MYOSIN
HEAVY CHAIN B,
ALPHA-ACTININ A
CHIMERA PROTEIN
(Dictyostelium
discoideum;
Homo
sapiens)
3 / 3TYR A 128
TYR A 109
ILE A 125
None
0.84A19.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ETE_B_H3PB552_1
(GLUTAMATE
DEHYDROGENASE)
4uhi STEROL 14-ALPHA
DEMETHYLASE
(Homo
sapiens)
3 / 3TYR A 426
TYR A 456
ILE A 367
None
0.85A20.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ETE_B_H3PB552_1
(GLUTAMATE
DEHYDROGENASE)
4uhy REPULSIVE GUIDANCE
MOLECULE A
(Homo
sapiens)
3 / 3TYR C  99
TYR C  82
ILE C 106
None
0.81A13.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ETE_B_H3PB552_1
(GLUTAMATE
DEHYDROGENASE)
4ui0 RGM DOMAIN FAMILY
MEMBER B
(Homo
sapiens)
3 / 3TYR C 105
TYR C  88
ILE C 112
None
0.84A12.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ETE_B_H3PB552_1
(GLUTAMATE
DEHYDROGENASE)
4ui2 REPULSIVE GUIDANCE
MOLECULE C, RGMC,
HEMOJUVELIN
(Homo
sapiens)
3 / 3TYR C 105
TYR C  88
ILE C 112
None
0.79A13.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ETE_B_H3PB552_1
(GLUTAMATE
DEHYDROGENASE)
5fqd DNA DAMAGE-BINDING
PROTEIN 1
(Homo
sapiens)
3 / 3TYR A 171
TYR A 271
ILE A 220
None
0.78A21.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ETE_B_H3PB552_1
(GLUTAMATE
DEHYDROGENASE)
5i4e MYOSIN-14,ALPHA-ACTI
NIN A
(Dictyostelium
discoideum;
Homo
sapiens)
3 / 3TYR A 148
TYR A 129
ILE A 145
AOV  A1500 (-4.4A)
None
None
0.76A19.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ETE_B_H3PB552_1
(GLUTAMATE
DEHYDROGENASE)
5ukw GLUCOSE-6-PHOSPHATE
1-DEHYDROGENASE
(Homo
sapiens)
3 / 3TYR A 107
TYR A  49
ILE A  36
None
0.71A23.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ETE_B_H3PB552_1
(GLUTAMATE
DEHYDROGENASE)
5vgr ATLASTIN-3
(Homo
sapiens)
3 / 3TYR A 192
TYR A 332
ILE A 331
None
0.75A19.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ETE_B_H3PB552_1
(GLUTAMATE
DEHYDROGENASE)
6flk CEP120
(Homo
sapiens)
3 / 3TYR A 509
TYR A 478
ILE A 489
None
0.78A9.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ETE_C_H3PC552_1
(GLUTAMATE
DEHYDROGENASE)
1n76 LACTOFERRIN
(Homo
sapiens)
3 / 3TYR A 324
TYR A  92
GLY A  61
None
FE  A 693 ( 4.2A)
None
0.74A21.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ETE_C_H3PC552_1
(GLUTAMATE
DEHYDROGENASE)
1n76 LACTOFERRIN
(Homo
sapiens)
3 / 3TYR A 667
TYR A 435
GLY A 397
None
FE  A 694 ( 4.1A)
None
0.73A21.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ETE_C_H3PC552_1
(GLUTAMATE
DEHYDROGENASE)
1ryo SEROTRANSFERRIN
(Homo
sapiens)
3 / 3TYR A 319
TYR A  95
GLY A  65
None
FE  A 329 ( 4.4A)
None
0.70A23.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ETE_C_H3PC552_1
(GLUTAMATE
DEHYDROGENASE)
1suv SEROTRANSFERRIN,
C-LOBE
(Homo
sapiens)
3 / 3TYR E 652
TYR E 425
GLY E 393
None
FE  E 703 ( 4.1A)
None
0.72A22.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ETE_C_H3PC552_1
(GLUTAMATE
DEHYDROGENASE)
1suv SEROTRANSFERRIN,
C-LOBE
(Homo
sapiens)
3 / 3TYR E 652
TYR E 425
GLY E 394
None
FE  E 703 ( 4.1A)
None
0.67A22.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ETE_C_H3PC552_1
(GLUTAMATE
DEHYDROGENASE)
2eiz ANTI-LYSOZYME
ANTIBODY FV REGION
(Homo
sapiens)
3 / 3TYR A  36
TYR B  47
GLY B 100
None
0.76A10.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ETE_C_H3PC552_1
(GLUTAMATE
DEHYDROGENASE)
2wvi MITOTIC CHECKPOINT
SERINE/THREONINE-PRO
TEIN KINASE BUB1
BETA
(Homo
sapiens)
3 / 3TYR A 116
TYR A 141
GLY A 111
None
0.65A15.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ETE_C_H3PC552_1
(GLUTAMATE
DEHYDROGENASE)
3ifq E-CADHERIN
PLAKOGLOBIN
(Homo
sapiens;
Mus
musculus)
3 / 3TYR A 297
TYR C 681
GLY C 685
SEP  C 684 ( 4.8A)
None
SEP  C 686 ( 2.4A)
0.64A23.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ETE_C_H3PC552_1
(GLUTAMATE
DEHYDROGENASE)
3zys DYNAMIN-1
(Homo
sapiens)
3 / 3TYR C  92
TYR C  33
GLY C  24
None
0.75A12.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ETE_C_H3PC552_1
(GLUTAMATE
DEHYDROGENASE)
5lcw MITOTIC CHECKPOINT
SERINE/THREONINE-PRO
TEIN KINASE BUB1
BETA,MITOTIC
CHECKPOINT
SERINE/THREONINE-PRO
TEIN KINASE BUB1
BETA
(Homo
sapiens)
3 / 3TYR S 116
TYR S 141
GLY S 111
None
0.59A20.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ETE_C_H3PC552_1
(GLUTAMATE
DEHYDROGENASE)
5xj3 IPILIMUMAB-VH
IPILIMUMAB-VL
(Homo
sapiens)
3 / 3TYR B  88
TYR A  95
GLY A  44
None
0.75A9.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ETE_C_H3PC552_1
(GLUTAMATE
DEHYDROGENASE)
6bdz DISINTEGRIN AND
METALLOPROTEINASE
DOMAIN-CONTAINING
PROTEIN 10
(Homo
sapiens)
3 / 3TYR A 257
TYR A 316
GLY A 386
None
0.68A10.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ETE_C_H3PC554_1
(GLUTAMATE
DEHYDROGENASE)
1ygu LEUKOCYTE COMMON
ANTIGEN
(Homo
sapiens)
4 / 5ILE A 824
TYR A 687
ILE A 715
HIS A 788
None
1.18A23.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ETE_C_H3PC554_1
(GLUTAMATE
DEHYDROGENASE)
2gf0 GTP-BINDING PROTEIN
DI-RAS1
(Homo
sapiens)
4 / 5ILE A  76
TYR A 101
ILE A 114
HIS A  80
None
0.95A16.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ETE_C_H3PC554_1
(GLUTAMATE
DEHYDROGENASE)
2lns ANTERIOR GRADIENT
PROTEIN 2 HOMOLOG
(Homo
sapiens)
4 / 5ILE A  74
MET A 164
ILE A 128
HIS A  77
None
1.15A15.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ETE_C_H3PC554_1
(GLUTAMATE
DEHYDROGENASE)
2p1f URIDINE
5'-MONOPHOSPHATE
SYNTHASE
(Homo
sapiens)
4 / 5ILE A 250
MET A  58
ILE A 257
HIS A 225
None
1.22A23.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ETE_C_H3PC554_1
(GLUTAMATE
DEHYDROGENASE)
3edi TOLLOID-LIKE PROTEIN
1
(Homo
sapiens)
4 / 5ILE A  77
TYR A  17
MET A  29
HIS A  92
None
DMS  A 215 (-4.3A)
None
ZN  A 210 (-3.2A)
1.08A18.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ETE_C_H3PC554_1
(GLUTAMATE
DEHYDROGENASE)
4db1 MYOSIN-7
(Homo
sapiens)
4 / 5ILE A 313
TYR A 283
ILE A 356
HIS A 358
None
0.96A20.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ETE_C_H3PC554_1
(GLUTAMATE
DEHYDROGENASE)
4gl2 INTERFERON-INDUCED
HELICASE C
DOMAIN-CONTAINING
PROTEIN 1
(Homo
sapiens)
4 / 5ILE A 484
TYR A 454
ILE A 441
HIS A 346
None
1.06A22.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ETE_C_H3PC554_1
(GLUTAMATE
DEHYDROGENASE)
4l87 SERINE--TRNA LIGASE,
CYTOPLASMIC
(Homo
sapiens)
4 / 5ILE A 276
TYR A 224
MET A 229
ILE A 269
None
1.05A21.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ETE_C_H3PC554_1
(GLUTAMATE
DEHYDROGENASE)
4p7h MYOSIN-7,GREEN
FLUORESCENT PROTEIN
(Aequorea
victoria;
Homo
sapiens)
4 / 5ILE A 313
TYR A 283
ILE A 356
HIS A 358
None
0.96A19.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ETE_C_H3PC554_1
(GLUTAMATE
DEHYDROGENASE)
4yhj G PROTEIN-COUPLED
RECEPTOR KINASE 4
(Homo
sapiens)
4 / 5ILE A 380
TYR A 292
ILE A 276
HIS A 383
None
1.18A20.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ETE_C_H3PC554_1
(GLUTAMATE
DEHYDROGENASE)
5ig3 CALCIUM/CALMODULIN-D
EPENDENT PROTEIN
KINASE TYPE II
SUBUNIT ALPHA
(Homo
sapiens)
4 / 5ILE A 350
TYR A 431
ILE A 464
HIS A 456
None
0.80A15.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ETE_C_H3PC554_1
(GLUTAMATE
DEHYDROGENASE)
5kj2 HISTONE
ACETYLTRANSFERASE
P300
(Homo
sapiens)
4 / 5ILE A1479
TYR A1421
ILE A1598
HIS A1481
None
1.21A23.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ETE_C_H3PC554_1
(GLUTAMATE
DEHYDROGENASE)
5lkz HISTONE
ACETYLTRANSFERASE
P300,HISTONE
ACETYLTRANSFERASE
P300
(Homo
sapiens)
4 / 5ILE A1479
TYR A1421
ILE A1598
HIS A1481
None
1.17A22.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ETE_C_H3PC554_1
(GLUTAMATE
DEHYDROGENASE)
5nfu SERINE/THREONINE-PRO
TEIN KINASE PLK1
(Homo
sapiens)
4 / 5ILE A 542
TYR A 552
ILE A 532
HIS A 524
None
1.07A10.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ETE_C_H3PC554_1
(GLUTAMATE
DEHYDROGENASE)
5zcs TARGET OF RAPAMYCIN
COMPLEX SUBUNIT LST8
(Homo
sapiens)
4 / 5ILE C 173
MET C 185
ILE C 144
HIS C 153
None
1.02A12.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ETE_C_H3PC554_1
(GLUTAMATE
DEHYDROGENASE)
6bsz METABOTROPIC
GLUTAMATE RECEPTOR 8
(Homo
sapiens)
4 / 5ILE A 209
MET A 502
ILE A 488
HIS A 490
None
1.24A12.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ETE_C_H3PC554_1
(GLUTAMATE
DEHYDROGENASE)
6glc E3 UBIQUITIN-PROTEIN
LIGASE PARKIN
(Homo
sapiens)
4 / 5ILE A 306
TYR A 267
ILE A 298
HIS A 302
None
None
None
MPD  A 510 (-4.2A)
1.13A10.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ETE_F_H3PF552_1
(GLUTAMATE
DEHYDROGENASE)
1ygu LEUKOCYTE COMMON
ANTIGEN
(Homo
sapiens)
4 / 7ILE A 715
HIS A 788
ILE A 824
TYR A 687
None
1.18A23.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ETE_F_H3PF552_1
(GLUTAMATE
DEHYDROGENASE)
2gf0 GTP-BINDING PROTEIN
DI-RAS1
(Homo
sapiens)
4 / 7ILE A 114
HIS A  80
ILE A  76
TYR A 101
None
0.97A16.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ETE_F_H3PF552_1
(GLUTAMATE
DEHYDROGENASE)
2lns ANTERIOR GRADIENT
PROTEIN 2 HOMOLOG
(Homo
sapiens)
4 / 7MET A 164
ILE A 128
HIS A  77
ILE A  74
None
1.15A15.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ETE_F_H3PF552_1
(GLUTAMATE
DEHYDROGENASE)
3d6t LEUCINE-RICH REPEAT
SERINE/THREONINE-PRO
TEIN KINASE 2
(Homo
sapiens)
4 / 7LYS B1468
ILE B1482
LYS B1439
TYR B1419
None
1.18A15.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ETE_F_H3PF552_1
(GLUTAMATE
DEHYDROGENASE)
3edi TOLLOID-LIKE PROTEIN
1
(Homo
sapiens)
4 / 7MET A  29
HIS A  92
ILE A  77
TYR A  17
None
ZN  A 210 (-3.2A)
None
DMS  A 215 (-4.3A)
1.06A18.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ETE_F_H3PF552_1
(GLUTAMATE
DEHYDROGENASE)
4cq1 POLYPYRIMIDINE
TRACT-BINDING
PROTEIN 2
(Homo
sapiens)
4 / 7MET A 400
ILE A 405
ILE A 380
TYR A 362
None
1.13A18.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ETE_F_H3PF552_1
(GLUTAMATE
DEHYDROGENASE)
4d61 EUKARYOTIC PEPTIDE
CHAIN RELEASE FACTOR
GTP-BINDING SUBUNIT
ERF3A
(Homo
sapiens)
4 / 7MET i 334
ILE i 529
HIS i 531
ILE i 526
None
1.16A23.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ETE_F_H3PF552_1
(GLUTAMATE
DEHYDROGENASE)
4db1 MYOSIN-7
(Homo
sapiens)
4 / 7ILE A 356
HIS A 358
ILE A 313
TYR A 283
None
0.97A20.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ETE_F_H3PF552_1
(GLUTAMATE
DEHYDROGENASE)
4gl2 INTERFERON-INDUCED
HELICASE C
DOMAIN-CONTAINING
PROTEIN 1
(Homo
sapiens)
4 / 7ILE A 441
HIS A 346
ILE A 484
TYR A 454
None
1.07A22.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ETE_F_H3PF552_1
(GLUTAMATE
DEHYDROGENASE)
4l87 SERINE--TRNA LIGASE,
CYTOPLASMIC
(Homo
sapiens)
4 / 7MET A 229
ILE A 269
ILE A 276
TYR A 224
None
1.05A21.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ETE_F_H3PF552_1
(GLUTAMATE
DEHYDROGENASE)
4p7h MYOSIN-7,GREEN
FLUORESCENT PROTEIN
(Aequorea
victoria;
Homo
sapiens)
4 / 7ILE A 356
HIS A 358
ILE A 313
TYR A 283
None
0.98A19.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ETE_F_H3PF552_1
(GLUTAMATE
DEHYDROGENASE)
5dot CARBAMOYL-PHOSPHATE
SYNTHASE [AMMONIA],
MITOCHONDRIAL
(Homo
sapiens)
4 / 7HIS A  63
LYS A 157
ILE A 126
TYR A  80
None
1.01A16.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ETE_F_H3PF552_1
(GLUTAMATE
DEHYDROGENASE)
5ig3 CALCIUM/CALMODULIN-D
EPENDENT PROTEIN
KINASE TYPE II
SUBUNIT ALPHA
(Homo
sapiens)
4 / 7ILE A 464
HIS A 456
ILE A 350
TYR A 431
None
0.81A15.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ETE_F_H3PF552_1
(GLUTAMATE
DEHYDROGENASE)
5law E3 UBIQUITIN-PROTEIN
LIGASE MDM2
(Homo
sapiens)
4 / 7ILE A  19
LYS A  94
ILE A  99
TYR A 104
None
6SJ  A 201 ( 2.7A)
6SJ  A 201 (-3.5A)
None
0.83A13.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ETE_F_H3PF552_1
(GLUTAMATE
DEHYDROGENASE)
5zcs TARGET OF RAPAMYCIN
COMPLEX SUBUNIT LST8
(Homo
sapiens)
4 / 7MET C 185
ILE C 144
HIS C 153
ILE C 173
None
1.03A12.09