POTENTIAL TARGETS FROM HUMAN (RESULTS FROM SUB-STRUCTURAL SIMILARITY SEARCHES)1) User may click on the DrReposER ID (the second column) to get information on the binding sites and drug molecule.
2) Click View (the second last column) to view matched residues and superposition in the NGL viewer (upper right part).
3) User may also click on the Dock (the last column) to get script for molecular docking in UCSF Chimera through AutoDock Vina.

	DrReposER ID / Desc.	Hit PDBID	Hit Macromolecule	Res. Matches	Interface	HETATM	RMSD	Seq. Identity (%)
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	1DX6_A_GNTA602_1 (ACETYLCHOLINESTERASE)	1b41	ACETYLCHOLINESTERASE (Homo sapiens)	6 / 12	ASP A 74 GLY A 122 TYR A 124 SER A 203 PHE A 338 HIS A 447	None	1.23A	57.67
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	1DX6_A_GNTA602_1 (ACETYLCHOLINESTERASE)	1b41	ACETYLCHOLINESTERASE (Homo sapiens)	11 / 12	ASP A 74 TRP A 86 GLY A 120 GLY A 121 GLY A 122 TYR A 124 SER A 203 TRP A 236 PHE A 297 PHE A 338 HIS A 447	None	0.53A	57.67
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	1DX6_A_GNTA602_1 (ACETYLCHOLINESTERASE)	1b41	ACETYLCHOLINESTERASE (Homo sapiens)	8 / 12	GLY A 120 GLY A 121 GLY A 122 TYR A 124 SER A 203 PHE A 297 PHE A 295 HIS A 447	None	1.09A	57.67
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	1DX6_A_GNTA602_1 (ACETYLCHOLINESTERASE)	1jmy	BILE-SALT-ACTIVATED LIPASE (Homo sapiens)	6 / 12	GLY A 106 GLY A 107 SER A 194 TRP A 227 PHE A 324 HIS A 435	None	0.47A	32.98
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	1DX6_A_GNTA602_1 (ACETYLCHOLINESTERASE)	1jmy	BILE-SALT-ACTIVATED LIPASE (Homo sapiens)	5 / 12	GLY A 107 SER A 194 TRP A 227 PHE A 324 HIS A 435	None	0.86A	32.98
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	1DX6_A_GNTA602_1 (ACETYLCHOLINESTERASE)	3k9b	LIVER CARBOXYLESTERASE 1 (Homo sapiens)	5 / 12	GLY A1141 GLY A1142 GLY A1143 SER A1221 HIS A1468	WW2 A 193 (-3.8A) WW2 A 193 (-3.4A) WW2 A 193 (-3.4A) WW2 A 193 (-1.4A) None	0.42A	37.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1DX6_A_GNTA602_1 (ACETYLCHOLINESTERASE)	4az3	LYSOSOMAL PROTECTIVE PROTEIN 20 KDA CHAIN LYSOSOMAL PROTECTIVE PROTEIN 32 KDA CHAIN (Homo sapiens)	5 / 12	ASP B 300 GLY A 56 GLY A 57 SER A 150 HIS B 429	None S35 A1259 ( 3.7A) S35 A1259 ( 3.6A) S35 A1259 ( 3.8A) S35 A1259 ( 3.9A)	0.98A	14.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1DX6_A_GNTA602_1 (ACETYLCHOLINESTERASE)	4mwt	LYSOSOMAL PROTECTIVE PROTEIN (Homo sapiens)	5 / 12	ASP A 300 GLY A 56 GLY A 57 SER A 150 HIS A 429	ASP A 300 ( 0.6A) GLY A 56 ( 0.0A) GLY A 57 ( 0.0A) SER A 150 ( 0.0A) HIS A 429 ( 1.0A)	1.01A	21.71
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	1DX6_A_GNTA602_1 (ACETYLCHOLINESTERASE)	4xii	CHOLINESTERASE (Homo sapiens)	9 / 12	ASP A 70 TRP A 82 GLY A 115 GLY A 116 GLY A 117 SER A 198 TRP A 231 PHE A 329 HIS A 438	40V A1001 (-4.2A) 40V A1001 (-3.3A) None 40V A1001 (-3.2A) 40V A1001 (-3.4A) 40V A1001 (-3.1A) 40V A1001 (-3.4A) 40V A1001 (-4.0A) 40V A1001 (-3.6A)	0.53A	52.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1DX6_A_GNTA602_1 (ACETYLCHOLINESTERASE)	5a1k	ADSEVERIN (Homo sapiens)	5 / 12	GLY A 234 GLY A 233 GLY A 163 PHE A 166 HIS A 141	None	1.00A	20.86
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	1QTI_A_GNTA600_1 (ACETYLCHOLINESTERASE)	1b41	ACETYLCHOLINESTERASE (Homo sapiens)	7 / 12	ASP A 74 GLY A 122 TYR A 124 GLU A 202 SER A 203 PHE A 338 HIS A 447	None	1.16A	57.67
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	1QTI_A_GNTA600_1 (ACETYLCHOLINESTERASE)	1b41	ACETYLCHOLINESTERASE (Homo sapiens)	12 / 12	ASP A 74 TRP A 86 GLY A 120 GLY A 121 GLY A 122 TYR A 124 GLU A 202 SER A 203 PHE A 295 PHE A 297 PHE A 338 HIS A 447	None	0.51A	57.67
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	1QTI_A_GNTA600_1 (ACETYLCHOLINESTERASE)	1b41	ACETYLCHOLINESTERASE (Homo sapiens)	6 / 12	GLY A 121 TYR A 124 SER A 203 PHE A 295 PHE A 338 HIS A 447	None	1.06A	57.67
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	1QTI_A_GNTA600_1 (ACETYLCHOLINESTERASE)	1b41	ACETYLCHOLINESTERASE (Homo sapiens)	6 / 12	GLY A 122 TYR A 124 GLU A 202 SER A 203 PHE A 338 HIS A 447	None	1.33A	57.67
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	1QTI_A_GNTA600_1 (ACETYLCHOLINESTERASE)	1b41	ACETYLCHOLINESTERASE (Homo sapiens)	6 / 12	GLY A 205 GLU A 202 SER A 203 PHE A 295 PHE A 297 HIS A 447	None	1.36A	57.67
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	1QTI_A_GNTA600_1 (ACETYLCHOLINESTERASE)	1jmy	BILE-SALT-ACTIVATED LIPASE (Homo sapiens)	6 / 12	GLY A 106 GLY A 107 GLU A 193 SER A 194 PHE A 324 HIS A 435	None	0.57A	33.33
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	1QTI_A_GNTA600_1 (ACETYLCHOLINESTERASE)	1jmy	BILE-SALT-ACTIVATED LIPASE (Homo sapiens)	6 / 12	GLY A 106 GLY A 107 GLU A 193 SER A 194 PHE A 324 HIS A 435	None	0.78A	33.33
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	1QTI_A_GNTA600_1 (ACETYLCHOLINESTERASE)	3k9b	LIVER CARBOXYLESTERASE 1 (Homo sapiens)	6 / 12	GLY A1141 GLY A1142 GLY A1143 GLU A1220 SER A1221 HIS A1468	WW2 A 193 (-3.8A) WW2 A 193 (-3.4A) WW2 A 193 (-3.4A) WW2 A 193 ( 4.2A) WW2 A 193 (-1.4A) None	0.51A	37.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1QTI_A_GNTA600_1 (ACETYLCHOLINESTERASE)	4mwt	LYSOSOMAL PROTECTIVE PROTEIN (Homo sapiens)	6 / 12	ASP A 300 GLY A 56 GLY A 57 GLU A 149 SER A 150 HIS A 429	ASP A 300 ( 0.6A) GLY A 56 ( 0.0A) GLY A 57 ( 0.0A) GLU A 149 ( 0.5A) SER A 150 ( 0.0A) HIS A 429 ( 1.0A)	1.14A	21.18
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	1QTI_A_GNTA600_1 (ACETYLCHOLINESTERASE)	4xii	CHOLINESTERASE (Homo sapiens)	9 / 12	ASP A 70 TRP A 82 GLY A 115 GLY A 116 GLY A 117 GLU A 197 SER A 198 PHE A 329 HIS A 438	40V A1001 (-4.2A) 40V A1001 (-3.3A) None 40V A1001 (-3.2A) 40V A1001 (-3.4A) 40V A1001 (-3.2A) 40V A1001 (-3.1A) 40V A1001 (-4.0A) 40V A1001 (-3.6A)	0.57A	52.77
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	1QTI_A_GNTA600_1 (ACETYLCHOLINESTERASE)	4xii	CHOLINESTERASE (Homo sapiens)	7 / 12	GLY A 115 GLY A 116 GLY A 117 GLU A 197 SER A 198 PHE A 329 HIS A 438	None 40V A1001 (-3.2A) 40V A1001 (-3.4A) 40V A1001 (-3.2A) 40V A1001 (-3.1A) 40V A1001 (-4.0A) 40V A1001 (-3.6A)	1.00A	52.77
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	1W6R_A_GNTA1536_1 (ACETYLCHOLINESTERASE)	1b41	ACETYLCHOLINESTERASE (Homo sapiens)	6 / 12	ASP A 74 GLY A 122 TYR A 124 SER A 203 PHE A 338 HIS A 447	None	1.24A	57.67
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	1W6R_A_GNTA1536_1 (ACETYLCHOLINESTERASE)	1b41	ACETYLCHOLINESTERASE (Homo sapiens)	11 / 12	ASP A 74 TRP A 86 GLY A 120 GLY A 121 GLY A 122 TYR A 124 SER A 203 PHE A 295 PHE A 297 PHE A 338 HIS A 447	None	0.51A	57.67
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	1W6R_A_GNTA1536_1 (ACETYLCHOLINESTERASE)	1b41	ACETYLCHOLINESTERASE (Homo sapiens)	7 / 12	GLY A 120 GLY A 121 GLY A 122 SER A 203 PHE A 297 PHE A 295 HIS A 447	None	1.16A	57.67
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	1W6R_A_GNTA1536_1 (ACETYLCHOLINESTERASE)	1b41	ACETYLCHOLINESTERASE (Homo sapiens)	7 / 12	GLY A 120 GLY A 121 GLY A 122 TYR A 124 SER A 203 PHE A 338 HIS A 447	None	0.95A	57.67
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	1W6R_A_GNTA1536_1 (ACETYLCHOLINESTERASE)	1jmy	BILE-SALT-ACTIVATED LIPASE (Homo sapiens)	5 / 12	GLY A 106 GLY A 107 SER A 194 PHE A 324 HIS A 435	None	0.51A	32.98
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	1W6R_A_GNTA1536_1 (ACETYLCHOLINESTERASE)	1jmy	BILE-SALT-ACTIVATED LIPASE (Homo sapiens)	5 / 12	GLY A 106 GLY A 107 SER A 194 PHE A 324 HIS A 435	None	0.80A	32.98
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	1W6R_A_GNTA1536_1 (ACETYLCHOLINESTERASE)	3k9b	LIVER CARBOXYLESTERASE 1 (Homo sapiens)	5 / 12	GLY A1141 GLY A1142 GLY A1143 SER A1221 HIS A1468	WW2 A 193 (-3.8A) WW2 A 193 (-3.4A) WW2 A 193 (-3.4A) WW2 A 193 (-1.4A) None	0.41A	37.19
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	1W6R_A_GNTA1536_1 (ACETYLCHOLINESTERASE)	4xii	CHOLINESTERASE (Homo sapiens)	8 / 12	ASP A 70 TRP A 82 GLY A 115 GLY A 116 GLY A 117 SER A 198 PHE A 329 HIS A 438	40V A1001 (-4.2A) 40V A1001 (-3.3A) None 40V A1001 (-3.2A) 40V A1001 (-3.4A) 40V A1001 (-3.1A) 40V A1001 (-4.0A) 40V A1001 (-3.6A)	0.58A	52.67
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	1W6R_A_GNTA1536_1 (ACETYLCHOLINESTERASE)	4xii	CHOLINESTERASE (Homo sapiens)	6 / 12	GLY A 115 GLY A 116 GLY A 117 SER A 198 PHE A 329 HIS A 438	None 40V A1001 (-3.2A) 40V A1001 (-3.4A) 40V A1001 (-3.1A) 40V A1001 (-4.0A) 40V A1001 (-3.6A)	1.11A	52.67
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	1W76_A_GNTA1538_1 (ACETYLCHOLINESTERASE)	1b41	ACETYLCHOLINESTERASE (Homo sapiens)	7 / 11	ASP A 74 GLY A 122 TYR A 124 GLU A 202 SER A 203 PHE A 338 HIS A 447	None	1.19A	57.67
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	1W76_A_GNTA1538_1 (ACETYLCHOLINESTERASE)	1b41	ACETYLCHOLINESTERASE (Homo sapiens)	10 / 11	ASP A 74 TRP A 86 GLY A 121 GLY A 122 TYR A 124 GLU A 202 SER A 203 PHE A 297 PHE A 338 HIS A 447	None	0.57A	57.67
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	1W76_A_GNTA1538_1 (ACETYLCHOLINESTERASE)	1b41	ACETYLCHOLINESTERASE (Homo sapiens)	7 / 11	GLY A 121 GLY A 122 GLU A 202 SER A 203 PHE A 297 PHE A 295 HIS A 447	None	1.10A	57.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1W76_A_GNTA1538_1 (ACETYLCHOLINESTERASE)	1gg3	ERYTHROID MEMBRANE PROTEIN 4.1R (Homo sapiens)	5 / 11	GLY A 188 TYR A 187 PHE A 277 PHE A 278 HIS A 274	None	1.31A	19.53
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	1W76_A_GNTA1538_1 (ACETYLCHOLINESTERASE)	1jmy	BILE-SALT-ACTIVATED LIPASE (Homo sapiens)	5 / 11	GLY A 107 GLU A 193 SER A 194 PHE A 324 HIS A 435	None	0.52A	32.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1W76_A_GNTA1538_1 (ACETYLCHOLINESTERASE)	3bin	BAND 4.1-LIKE PROTEIN 3 (Homo sapiens)	5 / 11	GLY A 297 TYR A 296 PHE A 386 PHE A 387 HIS A 383	None	1.38A	19.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1W76_A_GNTA1538_1 (ACETYLCHOLINESTERASE)	3gqc	DNA REPAIR PROTEIN REV1 (Homo sapiens)	5 / 11	GLY A 773 GLY A 772 TYR A 718 GLU A 466 PHE A 525	None	1.23A	21.86
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	1W76_A_GNTA1538_1 (ACETYLCHOLINESTERASE)	3k9b	LIVER CARBOXYLESTERASE 1 (Homo sapiens)	5 / 11	GLY A1142 GLY A1143 GLU A1220 SER A1221 HIS A1468	WW2 A 193 (-3.4A) WW2 A 193 (-3.4A) WW2 A 193 ( 4.2A) WW2 A 193 (-1.4A) None	0.47A	37.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1W76_A_GNTA1538_1 (ACETYLCHOLINESTERASE)	4i0p	HLA CLASS II HISTOCOMPATIBILITY ANTIGEN, DM BETA CHAIN HLA CLASS II HISTOCOMPATIBILITY ANTIGEN, DO ALPHA CHAIN (Homo sapiens)	5 / 11	ASP B 31 GLY C 58 GLY C 59 PHE C 32 HIS C 24	None	1.14A	14.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1W76_A_GNTA1538_1 (ACETYLCHOLINESTERASE)	4mwt	LYSOSOMAL PROTECTIVE PROTEIN (Homo sapiens)	5 / 11	ASP A 300 GLY A 57 GLU A 149 SER A 150 HIS A 429	ASP A 300 ( 0.6A) GLY A 57 ( 0.0A) GLU A 149 ( 0.5A) SER A 150 ( 0.0A) HIS A 429 ( 1.0A)	1.03A	21.71
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	1W76_A_GNTA1538_1 (ACETYLCHOLINESTERASE)	4xii	CHOLINESTERASE (Homo sapiens)	8 / 11	ASP A 70 TRP A 82 GLY A 116 GLY A 117 GLU A 197 SER A 198 PHE A 329 HIS A 438	40V A1001 (-4.2A) 40V A1001 (-3.3A) 40V A1001 (-3.2A) 40V A1001 (-3.4A) 40V A1001 (-3.2A) 40V A1001 (-3.1A) 40V A1001 (-4.0A) 40V A1001 (-3.6A)	0.55A	52.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1W76_A_GNTA1538_1 (ACETYLCHOLINESTERASE)	4ye4	HEAVY CHAIN HUMAN ANTIBODY HJ16 HT593.1 GP120 (Homo sapiens; Human immunodeficiency virus)	5 / 11	GLY G 458 GLY G 459 PHE H 111 PHE H 102 HIS H 103	None	1.30A	21.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1W76_A_GNTA1538_1 (ACETYLCHOLINESTERASE)	5mv9	UNCONVENTIONAL MYOSIN-VIIA (Homo sapiens)	5 / 11	TRP A1838 GLY A1842 GLU A1891 PHE A1844 PHE A1800	None	1.41A	24.23
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	1W76_B_GNTB1538_1 (ACETYLCHOLINESTERASE)	1b41	ACETYLCHOLINESTERASE (Homo sapiens)	7 / 10	ASP A 74 GLY A 122 TYR A 124 GLU A 202 SER A 203 PHE A 338 HIS A 447	None	1.19A	57.67
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	1W76_B_GNTB1538_1 (ACETYLCHOLINESTERASE)	1b41	ACETYLCHOLINESTERASE (Homo sapiens)	10 / 10	ASP A 74 TRP A 86 GLY A 120 GLY A 121 TYR A 124 GLU A 202 SER A 203 PHE A 297 PHE A 338 HIS A 447	None	0.55A	57.67
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	1W76_B_GNTB1538_1 (ACETYLCHOLINESTERASE)	1b41	ACETYLCHOLINESTERASE (Homo sapiens)	7 / 10	GLY A 120 GLY A 121 GLU A 202 SER A 203 PHE A 297 PHE A 295 HIS A 447	None	1.16A	57.67
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	1W76_B_GNTB1538_1 (ACETYLCHOLINESTERASE)	1jmy	BILE-SALT-ACTIVATED LIPASE (Homo sapiens)	6 / 10	GLY A 106 GLY A 107 GLU A 193 SER A 194 PHE A 324 HIS A 435	None	0.46A	32.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1W76_B_GNTB1538_1 (ACETYLCHOLINESTERASE)	2pvs	PANCREATIC LIPASE-RELATED PROTEIN 2 (Homo sapiens)	5 / 10	TRP A 85 GLY A 154 GLY A 76 SER A 152 HIS A 263	None	1.19A	21.89
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	1W76_B_GNTB1538_1 (ACETYLCHOLINESTERASE)	3k9b	LIVER CARBOXYLESTERASE 1 (Homo sapiens)	5 / 10	GLY A1141 GLY A1142 GLU A1220 SER A1221 HIS A1468	WW2 A 193 (-3.8A) WW2 A 193 (-3.4A) WW2 A 193 ( 4.2A) WW2 A 193 (-1.4A) None	0.50A	37.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1W76_B_GNTB1538_1 (ACETYLCHOLINESTERASE)	4az3	LYSOSOMAL PROTECTIVE PROTEIN 20 KDA CHAIN LYSOSOMAL PROTECTIVE PROTEIN 32 KDA CHAIN (Homo sapiens)	5 / 10	ASP B 300 GLY A 56 GLY A 57 SER A 150 HIS B 429	None S35 A1259 ( 3.7A) S35 A1259 ( 3.6A) S35 A1259 ( 3.8A) S35 A1259 ( 3.9A)	0.96A	14.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1W76_B_GNTB1538_1 (ACETYLCHOLINESTERASE)	4mwt	LYSOSOMAL PROTECTIVE PROTEIN (Homo sapiens)	5 / 10	ASP A 300 GLY A 56 GLY A 57 SER A 150 HIS A 429	ASP A 300 ( 0.6A) GLY A 56 ( 0.0A) GLY A 57 ( 0.0A) SER A 150 ( 0.0A) HIS A 429 ( 1.0A)	1.00A	21.71
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	1W76_B_GNTB1538_1 (ACETYLCHOLINESTERASE)	4xii	CHOLINESTERASE (Homo sapiens)	5 / 10	ASP A 70 GLY A 117 SER A 198 PHE A 329 HIS A 438	40V A1001 (-4.2A) 40V A1001 (-3.4A) 40V A1001 (-3.1A) 40V A1001 (-4.0A) 40V A1001 (-3.6A)	1.14A	52.67
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	1W76_B_GNTB1538_1 (ACETYLCHOLINESTERASE)	4xii	CHOLINESTERASE (Homo sapiens)	8 / 10	ASP A 70 TRP A 82 GLY A 115 GLY A 116 GLU A 197 SER A 198 PHE A 329 HIS A 438	40V A1001 (-4.2A) 40V A1001 (-3.3A) None 40V A1001 (-3.2A) 40V A1001 (-3.2A) 40V A1001 (-3.1A) 40V A1001 (-4.0A) 40V A1001 (-3.6A)	0.44A	52.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2PH9_A_GNTA301_1 (SOLUBLE ACETYLCHOLINE RECEPTOR)	1m9q	ENDOTHELIAL NITRIC-OXIDE SYNTHASE (Homo sapiens)	4 / 7	TYR A 251 TYR A 357 TYR A 373 ILE A 375	None 5NI A 907 (-4.6A) None None	1.34A	21.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2PH9_A_GNTA301_1 (SOLUBLE ACETYLCHOLINE RECEPTOR)	1xfd	DIPEPTIDYL AMINOPEPTIDASE-LIKE PROTEIN 6 (Homo sapiens)	4 / 7	TRP A 291 GLN A 403 TYR A 382 TYR A 344	None	1.25A	15.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2PH9_A_GNTA301_1 (SOLUBLE ACETYLCHOLINE RECEPTOR)	1ya0	SMG-7 TRANSCRIPT VARIANT 2 (Homo sapiens)	4 / 7	TYR A 102 TRP A 61 GLN A 41 TYR A 40	None	1.33A	20.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2PH9_A_GNTA301_1 (SOLUBLE ACETYLCHOLINE RECEPTOR)	2go0	REGENERATING ISLET-DERIVED PROTEIN 3 ALPHA (Homo sapiens)	4 / 7	TYR A 92 TRP A 120 TYR A 9 ILE A 66	None	1.10A	19.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2PH9_A_GNTA301_1 (SOLUBLE ACETYLCHOLINE RECEPTOR)	2jnu	REGULATOR OF G-PROTEIN SIGNALING 14 (Homo sapiens)	4 / 7	TYR A 69 TRP A 88 GLN A 76 ILE A 83	None	1.31A	20.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2PH9_A_GNTA301_1 (SOLUBLE ACETYLCHOLINE RECEPTOR)	3keh	GLUCOCEREBROSIDASE (Homo sapiens)	4 / 7	TRP A 378 TYR A 108 TYR A 363 ILE A 367	None	1.11A	17.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2PH9_A_GNTA301_1 (SOLUBLE ACETYLCHOLINE RECEPTOR)	3rgh	FILAMIN-A (Homo sapiens)	4 / 7	TYR A 229 GLN A 248 TYR A 221 ILE A 222	CME A 198 (-4.4A) None None None	1.31A	18.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2PH9_A_GNTA301_1 (SOLUBLE ACETYLCHOLINE RECEPTOR)	4cc1	PROTEIN JAGGED-1 (Homo sapiens)	4 / 7	TRP A 128 GLN A 83 TYR A 82 ILE A 161	None	1.21A	20.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2PH9_A_GNTA301_1 (SOLUBLE ACETYLCHOLINE RECEPTOR)	4d01	NEURONAL ACETYLCHOLINE RECEPTOR SUBUNIT ALPHA-9 (Homo sapiens)	4 / 7	TYR A 95 TRP A 151 TYR A 192 TYR A 199	EDO A1220 ( 4.1A) None None EDO A1220 (-3.8A)	0.59A	26.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2PH9_A_GNTA301_1 (SOLUBLE ACETYLCHOLINE RECEPTOR)	4d4l	6-PHOSPHOFRUCTO-2-KI NASE/FRUCTOSE-2,6-BI SPHOSPHATASE 3 (Homo sapiens)	4 / 7	TYR A 333 TYR A 408 TYR A 356 ILE A 323	F6P A1448 (-4.8A) None None None	1.19A	18.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2PH9_A_GNTA301_1 (SOLUBLE ACETYLCHOLINE RECEPTOR)	4p13	MEDIUM-CHAIN SPECIFIC ACYL-COA DEHYDROGENASE, MITOCHONDRIAL (Homo sapiens)	4 / 7	TYR A 375 GLN A 95 TYR A 133 ILE A 167	FAD A 401 (-4.9A) None FAD A 401 (-3.6A) FAD A 401 (-4.3A)	1.33A	20.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2PH9_A_GNTA301_1 (SOLUBLE ACETYLCHOLINE RECEPTOR)	4xbm	DELTA-LIKE PROTEIN 1 (Homo sapiens)	4 / 7	TYR A 79 TRP A 116 GLN A 68 TYR A 67	None	1.19A	17.57
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	2PH9_A_GNTA301_1 (SOLUBLE ACETYLCHOLINE RECEPTOR)	4zjs	ACETYLCHOLINE RECEPTOR SUBUNIT ALPHA,SOLUBLE ACETYLCHOLINE RECEPTOR,ACETYLCHOLI NE RECEPTOR SUBUNIT ALPHA,SOLUBLE ACETYLCHOLINE RECEPTOR (Aplysia californica; Homo sapiens)	5 / 7	TYR A 93 TRP A 147 GLN A 186 TYR A 188 TYR A 195	None	0.97A	82.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2PH9_A_GNTA301_1 (SOLUBLE ACETYLCHOLINE RECEPTOR)	5h64	SERINE/THREONINE-PRO TEIN KINASE MTOR (Homo sapiens)	4 / 7	GLN A1774 TYR A1775 TYR A1776 ILE A1764	None	1.34A	6.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2PH9_A_GNTA301_1 (SOLUBLE ACETYLCHOLINE RECEPTOR)	5htk	6-PHOSPHOFRUCTO-2-KI NASE/FRUCTOSE-2,6-BI SPHOSPHATASE 2 (Homo sapiens)	4 / 7	TYR A 337 TYR A 412 TYR A 360 ILE A 327	F6P A 604 (-4.6A) None None F6P A 604 ( 4.4A)	1.13A	19.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2PH9_A_GNTA301_1 (SOLUBLE ACETYLCHOLINE RECEPTOR)	5mw7	PROTEIN JAGGED-2 (Homo sapiens)	4 / 7	TYR A 90 TRP A 138 GLN A 79 ILE A 172	None	1.28A	19.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2PH9_A_GNTA301_1 (SOLUBLE ACETYLCHOLINE RECEPTOR)	5ndz	LYSOZYME,PROTEINASE- ACTIVATED RECEPTOR 2,SOLUBLE CYTOCHROME B562,PROTEINASE-ACTI VATED RECEPTOR 2 (Escherichia coli; Escherichia virus T4; Homo sapiens)	4 / 7	GLN A 214 TYR A 210 TYR A 160 ILE A 202	None 8UN A2201 (-3.9A) None 8UN A2201 ( 4.6A)	1.05A	16.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2PH9_A_GNTA301_1 (SOLUBLE ACETYLCHOLINE RECEPTOR)	5ndz	LYSOZYME,PROTEINASE- ACTIVATED RECEPTOR 2,SOLUBLE CYTOCHROME B562,PROTEINASE-ACTI VATED RECEPTOR 2 (Escherichia coli; Escherichia virus T4; Homo sapiens)	4 / 7	TYR A 242 GLN A 214 TYR A 160 ILE A 202	None None None 8UN A2201 ( 4.6A)	1.21A	16.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2PH9_A_GNTA301_1 (SOLUBLE ACETYLCHOLINE RECEPTOR)	5nj6	PROTEINASE-ACTIVATED RECEPTOR 2,SOLUBLE CYTOCHROME B562,PROTEINASE-ACTI VATED RECEPTOR 2 (Escherichia coli; Homo sapiens)	4 / 7	TYR A 242 GLN A 214 TYR A 160 ILE A 202	None	1.25A	17.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2PH9_A_GNTA301_1 (SOLUBLE ACETYLCHOLINE RECEPTOR)	5y3r	DNA-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT (Homo sapiens)	4 / 7	TYR C 408 GLN C 399 TYR C 366 ILE C 363	None	1.21A	4.74
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	4EY6_A_GNTA604_1 (ACETYLCHOLINESTERASE)	1b41	ACETYLCHOLINESTERASE (Homo sapiens)	9 / 12	GLY A 120 GLY A 121 GLY A 122 TYR A 124 SER A 125 SER A 203 PHE A 297 PHE A 295 HIS A 447	None	1.03A	100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	4EY6_A_GNTA604_1 (ACETYLCHOLINESTERASE)	1b41	ACETYLCHOLINESTERASE (Homo sapiens)	6 / 12	GLY A 121 TYR A 124 SER A 125 SER A 203 PHE A 295 HIS A 447	None	1.45A	100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	4EY6_A_GNTA604_1 (ACETYLCHOLINESTERASE)	1b41	ACETYLCHOLINESTERASE (Homo sapiens)	6 / 12	GLY A 122 TYR A 124 SER A 125 SER A 203 PHE A 338 HIS A 447	None	1.48A	100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	4EY6_A_GNTA604_1 (ACETYLCHOLINESTERASE)	1b41	ACETYLCHOLINESTERASE (Homo sapiens)	12 / 12	TRP A 86 GLY A 120 GLY A 121 GLY A 122 TYR A 124 SER A 125 SER A 203 PHE A 295 PHE A 297 TYR A 337 PHE A 338 HIS A 447	None	0.37A	100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	4EY6_A_GNTA604_1 (ACETYLCHOLINESTERASE)	1b41	ACETYLCHOLINESTERASE (Homo sapiens)	6 / 12	TRP A 86 GLY A 121 SER A 203 PHE A 295 PHE A 338 HIS A 447	None	1.11A	100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	4EY6_A_GNTA604_1 (ACETYLCHOLINESTERASE)	1jmy	BILE-SALT-ACTIVATED LIPASE (Homo sapiens)	5 / 12	GLY A 106 GLY A 107 SER A 194 PHE A 324 HIS A 435	None	0.42A	33.27
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	4EY6_A_GNTA604_1 (ACETYLCHOLINESTERASE)	1jmy	BILE-SALT-ACTIVATED LIPASE (Homo sapiens)	5 / 12	GLY A 106 GLY A 107 SER A 194 PHE A 324 HIS A 435	None	0.88A	33.27
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	4EY6_A_GNTA604_1 (ACETYLCHOLINESTERASE)	3k9b	LIVER CARBOXYLESTERASE 1 (Homo sapiens)	5 / 12	GLY A1141 GLY A1142 GLY A1143 SER A1221 HIS A1468	WW2 A 193 (-3.8A) WW2 A 193 (-3.4A) WW2 A 193 (-3.4A) WW2 A 193 (-1.4A) None	0.39A	36.13
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	4EY6_A_GNTA604_1 (ACETYLCHOLINESTERASE)	4xii	CHOLINESTERASE (Homo sapiens)	6 / 12	GLY A 115 GLY A 116 GLY A 117 SER A 198 PHE A 329 HIS A 438	None 40V A1001 (-3.2A) 40V A1001 (-3.4A) 40V A1001 (-3.1A) 40V A1001 (-4.0A) 40V A1001 (-3.6A)	1.17A	52.78
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	4EY6_A_GNTA604_1 (ACETYLCHOLINESTERASE)	4xii	CHOLINESTERASE (Homo sapiens)	7 / 12	TRP A 82 GLY A 115 GLY A 116 GLY A 117 SER A 198 PHE A 329 HIS A 438	40V A1001 (-3.3A) None 40V A1001 (-3.2A) 40V A1001 (-3.4A) 40V A1001 (-3.1A) 40V A1001 (-4.0A) 40V A1001 (-3.6A)	0.56A	52.78
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	4EY6_B_GNTB605_1 (ACETYLCHOLINESTERASE)	1b41	ACETYLCHOLINESTERASE (Homo sapiens)	9 / 12	GLY A 120 GLY A 121 GLY A 122 TYR A 124 GLU A 202 SER A 203 PHE A 297 PHE A 295 HIS A 447	None	1.02A	100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	4EY6_B_GNTB605_1 (ACETYLCHOLINESTERASE)	1b41	ACETYLCHOLINESTERASE (Homo sapiens)	6 / 12	GLY A 121 TYR A 124 GLU A 202 SER A 203 PHE A 295 HIS A 447	None	1.38A	100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	4EY6_B_GNTB605_1 (ACETYLCHOLINESTERASE)	1b41	ACETYLCHOLINESTERASE (Homo sapiens)	6 / 12	GLY A 122 TYR A 124 GLU A 202 SER A 203 PHE A 338 HIS A 447	None	1.40A	100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	4EY6_B_GNTB605_1 (ACETYLCHOLINESTERASE)	1b41	ACETYLCHOLINESTERASE (Homo sapiens)	6 / 12	GLY A 205 GLU A 202 SER A 203 PHE A 295 PHE A 297 HIS A 447	None	1.26A	100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	4EY6_B_GNTB605_1 (ACETYLCHOLINESTERASE)	1b41	ACETYLCHOLINESTERASE (Homo sapiens)	12 / 12	TRP A 86 GLY A 120 GLY A 121 GLY A 122 TYR A 124 GLU A 202 SER A 203 PHE A 295 PHE A 297 TYR A 337 PHE A 338 HIS A 447	None	0.36A	100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	4EY6_B_GNTB605_1 (ACETYLCHOLINESTERASE)	1b41	ACETYLCHOLINESTERASE (Homo sapiens)	6 / 12	TRP A 86 GLY A 120 PHE A 295 TYR A 337 PHE A 338 HIS A 447	None	1.01A	100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	4EY6_B_GNTB605_1 (ACETYLCHOLINESTERASE)	1jmy	BILE-SALT-ACTIVATED LIPASE (Homo sapiens)	6 / 12	GLY A 106 GLY A 107 GLU A 193 SER A 194 PHE A 324 HIS A 435	None	0.41A	33.27
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	4EY6_B_GNTB605_1 (ACETYLCHOLINESTERASE)	1jmy	BILE-SALT-ACTIVATED LIPASE (Homo sapiens)	6 / 12	GLY A 106 GLY A 107 GLU A 193 SER A 194 PHE A 324 HIS A 435	None	0.88A	33.27
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	4EY6_B_GNTB605_1 (ACETYLCHOLINESTERASE)	3k9b	LIVER CARBOXYLESTERASE 1 (Homo sapiens)	6 / 12	GLY A1141 GLY A1142 GLY A1143 GLU A1220 SER A1221 HIS A1468	WW2 A 193 (-3.8A) WW2 A 193 (-3.4A) WW2 A 193 (-3.4A) WW2 A 193 ( 4.2A) WW2 A 193 (-1.4A) None	0.53A	36.13
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	4EY6_B_GNTB605_1 (ACETYLCHOLINESTERASE)	4xii	CHOLINESTERASE (Homo sapiens)	7 / 12	GLY A 115 GLY A 116 GLY A 117 GLU A 197 SER A 198 PHE A 329 HIS A 438	None 40V A1001 (-3.2A) 40V A1001 (-3.4A) 40V A1001 (-3.2A) 40V A1001 (-3.1A) 40V A1001 (-4.0A) 40V A1001 (-3.6A)	1.13A	52.78
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	4EY6_B_GNTB605_1 (ACETYLCHOLINESTERASE)	4xii	CHOLINESTERASE (Homo sapiens)	8 / 12	TRP A 82 GLY A 115 GLY A 116 GLY A 117 GLU A 197 SER A 198 PHE A 329 HIS A 438	40V A1001 (-3.3A) None 40V A1001 (-3.2A) 40V A1001 (-3.4A) 40V A1001 (-3.2A) 40V A1001 (-3.1A) 40V A1001 (-4.0A) 40V A1001 (-3.6A)	0.58A	52.78