POTENTIAL TARGETS FROM HUMAN (RESULTS FROM SUB-STRUCTURAL SIMILARITY SEARCHES)1) User may click on the DrReposER ID (the second column) to get information on the binding sites and drug molecule.
2) Click View (the second last column) to view matched residues and superposition in the NGL viewer (upper right part).
3) User may also click on the Dock (the last column) to get script for molecular docking in UCSF Chimera through AutoDock Vina.

	DrReposER ID / Desc.	Hit PDBID	Hit Macromolecule	Res. Matches	Interface	HETATM	RMSD	Seq. Identity (%)	View	Dock
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	4YVX_A_GMRA401_1 (ALDO-KETO REDUCTASE FAMILY 1 MEMBER C3)	2fvl	ALDO-KETO REDUCTASE FAMILY 1, MEMBER C4 (Homo sapiens)	7 / 12	TYR A  24 LEU A  54 TYR A  55 TRP A  86 HIS A 117 LEU A 122 ASN A 167	None None NAP  A1001 (-4.7A) None NAP  A1001 (-4.4A) None NAP  A1001 (-3.1A)	0.24A	84.21
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	4YVX_A_GMRA401_1 (ALDO-KETO REDUCTASE FAMILY 1 MEMBER C3)	2is7	ALDOSE REDUCTASE (Homo sapiens)	5 / 12	TYR A  48 TRP A  79 HIS A 110 ASN A 160 SER A 302	2CL  A 317 ( 4.5A) None 2CL  A 317 ( 3.8A) NAP  A 316 (-3.4A) None	0.90A	48.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4YVX_A_GMRA401_1 (ALDO-KETO REDUCTASE FAMILY 1 MEMBER C3)	4x90	GROUP XV PHOSPHOLIPASE A2 (Homo sapiens)	5 / 12	LEU A 363 TYR A 104 HIS A 164 LEU A 354 ASN A 168	None None None NAG  A 404 (-4.0A) None	1.37A	21.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4YVX_A_GMRA401_1 (ALDO-KETO REDUCTASE FAMILY 1 MEMBER C3)	5udh	E3 UBIQUITIN-PROTEIN LIGASE ARIH1 (Homo sapiens)	5 / 12	LEU A 472 TYR A 476 HIS A 424 SER A 427 LEU A 465	None	1.50A	21.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4YVX_A_GMRA401_1 (ALDO-KETO REDUCTASE FAMILY 1 MEMBER C3)	5w2h	INOSITOL POLYPHOSPHATE MULTIKINASE,INOSITOL POLYPHOSPHATE MULTIKINASE (Homo sapiens)	5 / 12	TYR A  94 LEU A 106 TRP A 239 PHE A 276 SER A 251	None	1.44A	22.62
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	4YVX_A_GMRA401_1 (ALDO-KETO REDUCTASE FAMILY 1 MEMBER C3)	6f2u	ALDO-KETO REDUCTASE FAMILY 1 MEMBER C3 (Homo sapiens)	9 / 12	TYR A  24 LEU A  54 TYR A  55 TRP A  86 HIS A 117 SER A 118 ASN A 167 TRP A 227 PHE A 306	CJ2  A 402 (-4.2A) None CJ2  A 402 ( 4.1A) None CJ2  A 402 ( 3.8A) CJ2  A 402 ( 3.7A) NAP  A 401 ( 3.3A) CJ2  A 402 ( 4.8A) CJ2  A 402 (-3.8A)	0.92A	100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	4YVX_A_GMRA401_1 (ALDO-KETO REDUCTASE FAMILY 1 MEMBER C3)	6f2u	ALDO-KETO REDUCTASE FAMILY 1 MEMBER C3 (Homo sapiens)	10 / 12	TYR A  24 LEU A  54 TYR A  55 TRP A  86 HIS A 117 SER A 118 LEU A 122 SER A 129 ASN A 167 PHE A 306	CJ2  A 402 (-4.2A) None CJ2  A 402 ( 4.1A) None CJ2  A 402 ( 3.8A) CJ2  A 402 ( 3.7A) None None NAP  A 401 ( 3.3A) CJ2  A 402 (-3.8A)	0.49A	100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	4YVX_B_GMRB401_1 (ALDO-KETO REDUCTASE FAMILY 1 MEMBER C3)	2fvl	ALDO-KETO REDUCTASE FAMILY 1, MEMBER C4 (Homo sapiens)	8 / 12	TYR A  24 LEU A  54 TYR A  55 TRP A  86 HIS A 117 MET A 120 LEU A 122 ASN A 167	None None NAP  A1001 (-4.7A) None NAP  A1001 (-4.4A) None None NAP  A1001 (-3.1A)	0.41A	84.21
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	4YVX_B_GMRB401_1 (ALDO-KETO REDUCTASE FAMILY 1 MEMBER C3)	3cav	3-OXO-5-BETA-STEROID 4-DEHYDROGENASE (Homo sapiens)	5 / 12	TYR A  26 TYR A  58 TRP A  89 MET A 123 ASN A 170	CI2  A 328 ( 4.0A) CI2  A 328 ( 4.5A) None None NAP  A 327 (-3.6A)	0.50A	55.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4YVX_B_GMRB401_1 (ALDO-KETO REDUCTASE FAMILY 1 MEMBER C3)	3p8c	NCK-ASSOCIATED PROTEIN 1 (Homo sapiens)	5 / 12	LEU B1087 HIS B1025 SER B1016 LEU B 904 ASN B1080	None	1.45A	15.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4YVX_B_GMRB401_1 (ALDO-KETO REDUCTASE FAMILY 1 MEMBER C3)	4x90	GROUP XV PHOSPHOLIPASE A2 (Homo sapiens)	5 / 12	LEU A 363 TYR A 104 HIS A 164 LEU A 354 ASN A 168	None None None NAG  A 404 (-4.0A) None	1.32A	21.17
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	4YVX_B_GMRB401_1 (ALDO-KETO REDUCTASE FAMILY 1 MEMBER C3)	6f2u	ALDO-KETO REDUCTASE FAMILY 1 MEMBER C3 (Homo sapiens)	6 / 12	TYR A  24 LEU A  54 TYR A  55 HIS A 117 SER A  87 TRP A 227	CJ2  A 402 (-4.2A) None CJ2  A 402 ( 4.1A) CJ2  A 402 ( 3.8A) None CJ2  A 402 ( 4.8A)	1.49A	100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	4YVX_B_GMRB401_1 (ALDO-KETO REDUCTASE FAMILY 1 MEMBER C3)	6f2u	ALDO-KETO REDUCTASE FAMILY 1 MEMBER C3 (Homo sapiens)	10 / 12	TYR A  24 LEU A  54 TYR A  55 TRP A  86 HIS A 117 SER A 118 MET A 120 ASN A 167 TRP A 227 PHE A 306	CJ2  A 402 (-4.2A) None CJ2  A 402 ( 4.1A) None CJ2  A 402 ( 3.8A) CJ2  A 402 ( 3.7A) CJ2  A 402 ( 4.7A) NAP  A 401 ( 3.3A) CJ2  A 402 ( 4.8A) CJ2  A 402 (-3.8A)	0.82A	100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	4YVX_B_GMRB401_1 (ALDO-KETO REDUCTASE FAMILY 1 MEMBER C3)	6f2u	ALDO-KETO REDUCTASE FAMILY 1 MEMBER C3 (Homo sapiens)	11 / 12	TYR A  24 LEU A  54 TYR A  55 TRP A  86 HIS A 117 SER A 118 MET A 120 LEU A 122 SER A 129 ASN A 167 PHE A 306	CJ2  A 402 (-4.2A) None CJ2  A 402 ( 4.1A) None CJ2  A 402 ( 3.8A) CJ2  A 402 ( 3.7A) CJ2  A 402 ( 4.7A) None None NAP  A 401 ( 3.3A) CJ2  A 402 (-3.8A)	0.34A	100.00