POTENTIAL TARGETS FROM HUMAN (RESULTS FROM SUB-STRUCTURAL SIMILARITY SEARCHES)1) User may click on the DrReposER ID (the second column) to get information on the binding sites and drug molecule.
2) Click View (the second last column) to view matched residues and superposition in the NGL viewer (upper right part).
3) User may also click on the Dock (the last column) to get script for molecular docking in UCSF Chimera through AutoDock Vina.

	DrReposER ID / Desc.	Hit PDBID	Hit Macromolecule	Res. Matches	Interface	HETATM	RMSD	Seq. Identity (%)	View	Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	6DJZ_A_GMJA301_0 (SIGMA NON-OPIOID INTRACELLULAR RECEPTOR 1)	1dbh	PROTEIN (HUMAN SOS 1) (Homo sapiens)	5 / 12	MET A 538 LEU A 541 ILE A 461 HIS A 460 ALA A 528	None	1.20A	20.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	6DJZ_A_GMJA301_0 (SIGMA NON-OPIOID INTRACELLULAR RECEPTOR 1)	1fu1	DNA REPAIR PROTEIN XRCC4 (Homo sapiens)	5 / 12	LEU A  28 ILE A  34 LEU A 108 ALA A  73 TYR A  66	None None ACY  A 501 ( 4.9A) None None	1.08A	20.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	6DJZ_A_GMJA301_0 (SIGMA NON-OPIOID INTRACELLULAR RECEPTOR 1)	1fu1	DNA REPAIR PROTEIN XRCC4 (Homo sapiens)	5 / 12	LEU A  28 ILE A  34 THR A  37 LEU A 108 TYR A  66	None None None ACY  A 501 ( 4.9A) None	1.24A	20.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	6DJZ_A_GMJA301_0 (SIGMA NON-OPIOID INTRACELLULAR RECEPTOR 1)	1luj	CATENIN BETA-1 (Homo sapiens)	5 / 12	LEU A 498 ILE A 569 VAL A 564 LEU A 577 ALA A 576	None	1.21A	19.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	6DJZ_A_GMJA301_0 (SIGMA NON-OPIOID INTRACELLULAR RECEPTOR 1)	1xdv	SON OF SEVENLESS PROTEIN HOMOLOG 1 (Homo sapiens)	5 / 12	MET A 538 LEU A 541 ILE A 461 HIS A 460 ALA A 528	None	1.19A	14.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	6DJZ_A_GMJA301_0 (SIGMA NON-OPIOID INTRACELLULAR RECEPTOR 1)	1zrz	PROTEIN KINASE C, IOTA (Homo sapiens)	5 / 12	LEU A 430 ILE A 507 VAL A 516 LEU A 360 ALA A 356	None	1.18A	21.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	6DJZ_A_GMJA301_0 (SIGMA NON-OPIOID INTRACELLULAR RECEPTOR 1)	3mud	DNA REPAIR PROTEIN XRCC4,TROPOMYOSIN ALPHA-1 CHAIN (Gallus gallus; Homo sapiens)	5 / 12	LEU A  28 ILE A  34 LEU A 108 ALA A  73 TYR A  66	None	1.00A	20.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	6DJZ_A_GMJA301_0 (SIGMA NON-OPIOID INTRACELLULAR RECEPTOR 1)	3q4f	DNA REPAIR PROTEIN XRCC4 (Homo sapiens)	5 / 12	LEU C  28 ILE C  34 LEU C 108 ALA C  73 TYR C  66	None	1.18A	19.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	6DJZ_A_GMJA301_0 (SIGMA NON-OPIOID INTRACELLULAR RECEPTOR 1)	3w03	DNA REPAIR PROTEIN XRCC4 (Homo sapiens)	5 / 12	LEU C  28 ILE C  34 LEU C 108 ALA C  73 TYR C  66	None	1.08A	18.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	6DJZ_A_GMJA301_0 (SIGMA NON-OPIOID INTRACELLULAR RECEPTOR 1)	3w03	DNA REPAIR PROTEIN XRCC4 (Homo sapiens)	5 / 12	LEU C  28 ILE C  34 THR C  37 LEU C 108 TYR C  66	None	1.24A	18.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	6DJZ_A_GMJA301_0 (SIGMA NON-OPIOID INTRACELLULAR RECEPTOR 1)	4gnk	1-PHOSPHATIDYLINOSIT OL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-3 (Homo sapiens)	5 / 12	VAL B 823 THR B 842 VAL B 730 LEU B 791 ALA B 792	None	1.23A	10.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	6DJZ_A_GMJA301_0 (SIGMA NON-OPIOID INTRACELLULAR RECEPTOR 1)	4keg	MALTOSE-BINDING PERIPLASMIC/PALATE LUNG AND NASAL EPITHELIUM CLONE FUSION PROTEIN (Escherichia coli; Homo sapiens)	5 / 12	LEU A1234 ILE A1163 PHE A1252 VAL A1253 LEU A1059	None	1.21A	18.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	6DJZ_A_GMJA301_0 (SIGMA NON-OPIOID INTRACELLULAR RECEPTOR 1)	4p5w	CALCIUM-BINDING MITOCHONDRIAL CARRIER PROTEIN ARALAR2,CALCIUM-BIND ING MITOCHONDRIAL CARRIER PROTEIN ARALAR2 (Homo sapiens)	5 / 12	ILE A 650 PHE A  99 THR A 119 VAL A 115 LEU A  45	None	1.10A	19.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	6DJZ_A_GMJA301_0 (SIGMA NON-OPIOID INTRACELLULAR RECEPTOR 1)	4qj4	1-PHOSPHATIDYLINOSIT OL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-3 (Homo sapiens)	5 / 12	LEU B 685 VAL B 823 THR B 842 VAL B 730 LEU B 791	None	1.05A	14.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	6DJZ_A_GMJA301_0 (SIGMA NON-OPIOID INTRACELLULAR RECEPTOR 1)	5chx	XRCC4-MYH7-1590-1657 (Homo sapiens)	5 / 12	LEU A  28 ILE A  34 LEU A 108 ALA A  73 TYR A  66	None None MLY  A  99 ( 4.5A) MLY  A  72 ( 3.6A) None	1.07A	21.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	6DJZ_A_GMJA301_0 (SIGMA NON-OPIOID INTRACELLULAR RECEPTOR 1)	5cj0	XRCC4-MYH7-(1631-169 2) CHIMERA PROTEIN (Homo sapiens)	5 / 12	LEU A  28 ILE A  34 LEU A 108 ALA A  73 TYR A  66	None	1.11A	21.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	6DJZ_A_GMJA301_0 (SIGMA NON-OPIOID INTRACELLULAR RECEPTOR 1)	5cj4	XRCC4-MYH7-(1562-162 2) CHIMERA PROTEIN (Homo sapiens)	5 / 12	LEU A  28 ILE A  34 LEU A 108 ALA A  73 TYR A  66	None None MLY  A  99 ( 4.8A) MLY  A  72 ( 3.6A) None	1.12A	22.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	6DJZ_A_GMJA301_0 (SIGMA NON-OPIOID INTRACELLULAR RECEPTOR 1)	5clw	1,4-ALPHA-GLUCAN-BRA NCHING ENZYME (Homo sapiens)	5 / 12	LEU A 663 THR A 640 VAL A 638 ALA A 692 TYR A 657	None	1.13A	16.29
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	6DJZ_A_GMJA301_0 (SIGMA NON-OPIOID INTRACELLULAR RECEPTOR 1)	5hk2	SIGMA NON-OPIOID INTRACELLULAR RECEPTOR 1 (Homo sapiens)	6 / 12	ILE A 124 PHE A 133 VAL A 152 HIS A 154 THR A 160 ALA A  86	61V  A 301 ( 4.7A) None None 61V  A 301 ( 4.1A) None None	1.00A	100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	6DJZ_A_GMJA301_0 (SIGMA NON-OPIOID INTRACELLULAR RECEPTOR 1)	5hk2	SIGMA NON-OPIOID INTRACELLULAR RECEPTOR 1 (Homo sapiens)	9 / 12	MET A  93 LEU A 105 PHE A 133 VAL A 152 HIS A 154 THR A 160 VAL A 162 LEU A 186 ALA A 185	61V  A 301 (-3.4A) None None None 61V  A 301 ( 4.1A) None None None 61V  A 301 ( 4.2A)	1.49A	100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	6DJZ_A_GMJA301_0 (SIGMA NON-OPIOID INTRACELLULAR RECEPTOR 1)	5hk2	SIGMA NON-OPIOID INTRACELLULAR RECEPTOR 1 (Homo sapiens)	12 / 12	MET A  93 TYR A 103 LEU A 105 ILE A 124 PHE A 133 VAL A 152 HIS A 154 THR A 160 VAL A 162 LEU A 182 ALA A 185 TYR A 206	61V  A 301 (-3.4A) 61V  A 301 ( 4.3A) None 61V  A 301 ( 4.7A) None None 61V  A 301 ( 4.1A) None None None 61V  A 301 ( 4.2A) 61V  A 301 (-3.6A)	0.58A	100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	6DJZ_A_GMJA301_0 (SIGMA NON-OPIOID INTRACELLULAR RECEPTOR 1)	5hk2	SIGMA NON-OPIOID INTRACELLULAR RECEPTOR 1 (Homo sapiens)	6 / 12	PHE A 133 VAL A 152 HIS A 154 THR A 160 LEU A 186 ALA A  86	None None 61V  A 301 ( 4.1A) None None None	0.95A	100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	6DJZ_A_GMJA301_0 (SIGMA NON-OPIOID INTRACELLULAR RECEPTOR 1)	5ko9	EMBRYONIC STEM CELL-SPECIFIC 5-HYDROXYMETHYLCYTOS INE-BINDING PROTEIN (Homo sapiens)	5 / 12	LEU A 238 ILE A 179 THR A  94 LEU A 217 ALA A 215	None	1.13A	20.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	6DJZ_A_GMJA301_0 (SIGMA NON-OPIOID INTRACELLULAR RECEPTOR 1)	5wj7	DNA REPAIR PROTEIN XRCC4,MYOSIN-7 (Homo sapiens)	5 / 12	LEU A  28 ILE A  34 LEU A 108 ALA A  73 TYR A  66	None	1.22A	21.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	6DJZ_A_GMJA301_0 (SIGMA NON-OPIOID INTRACELLULAR RECEPTOR 1)	5wlz	DNA REPAIR PROTEIN XRCC4,MYOSIN-7 (Homo sapiens)	5 / 12	LEU C  28 ILE C  34 LEU C 108 ALA C  73 TYR C  66	None	1.18A	18.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	6DJZ_A_GMJA301_1 (SIGMA NON-OPIOID INTRACELLULAR RECEPTOR 1)	1x03	SH3-CONTAINING GRB2-LIKE PROTEIN 2 (Homo sapiens)	4 / 6	SER A  44 ASP A 148 GLN A 155 THR A  52	None	1.32A	22.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	6DJZ_A_GMJA301_1 (SIGMA NON-OPIOID INTRACELLULAR RECEPTOR 1)	2aex	COPROPORPHYRINOGEN III OXIDASE, MITOCHONDRIAL (Homo sapiens)	4 / 6	SER A 420 TYR A 392 ASP A 400 THR A 284	None	1.23A	21.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	6DJZ_A_GMJA301_1 (SIGMA NON-OPIOID INTRACELLULAR RECEPTOR 1)	2hck	HEMATOPOETIC CELL KINASE HCK (Homo sapiens)	4 / 6	SER A 266 TYR A 286 GLU A 255 THR A 290	None	1.40A	18.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	6DJZ_A_GMJA301_1 (SIGMA NON-OPIOID INTRACELLULAR RECEPTOR 1)	2qqo	NEUROPILIN-2 (Homo sapiens)	4 / 6	SER A 470 ASP A 371 GLN A 504 GLU A 370	None	1.49A	19.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	6DJZ_A_GMJA301_1 (SIGMA NON-OPIOID INTRACELLULAR RECEPTOR 1)	2xyd	ANGIOTENSIN-CONVERTI NG ENZYME (Homo sapiens)	4 / 6	SER A 333 GLN A 347 GLU A 389 THR A 496	3ES  A1611 (-4.4A) None ZN  A1620 ( 2.4A) 3ES  A1611 (-3.4A)	1.41A	17.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	6DJZ_A_GMJA301_1 (SIGMA NON-OPIOID INTRACELLULAR RECEPTOR 1)	4wk4	INTEGRIN ALPHA-5 (Homo sapiens)	4 / 6	SER A  77 TYR A 119 GLN A  46 GLU A 147	None	1.33A	18.51
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	6DJZ_A_GMJA301_1 (SIGMA NON-OPIOID INTRACELLULAR RECEPTOR 1)	5hk2	SIGMA NON-OPIOID INTRACELLULAR RECEPTOR 1 (Homo sapiens)	6 / 6	SER A 117 TYR A 120 ASP A 126 GLN A 135 GLU A 172 THR A 181	61V  A 301 (-2.9A) None 61V  A 301 (-3.2A) None 61V  A 301 (-2.9A) 61V  A 301 ( 4.7A)	0.56A	100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	6DJZ_A_GMJA301_1 (SIGMA NON-OPIOID INTRACELLULAR RECEPTOR 1)	5vhj	26S PROTEASOME REGULATORY SUBUNIT 8 (Homo sapiens)	4 / 6	ASP C 394 GLN C 392 GLU C 358 THR C 364	None	1.33A	22.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	6DJZ_A_GMJA301_1 (SIGMA NON-OPIOID INTRACELLULAR RECEPTOR 1)	6f9n	CLEAVAGE AND POLYADENYLATION SPECIFICITY FACTOR SUBUNIT 1 (Homo sapiens)	4 / 6	SER A 582 ASP A 596 GLN A 603 GLU A 594	None	1.39A	undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	6DJZ_B_GMJB301_0 (SIGMA NON-OPIOID INTRACELLULAR RECEPTOR 1)	2aw5	NADP-DEPENDENT MALIC ENZYME (Homo sapiens)	5 / 12	LEU A 256 SER A 275 THR A 481 VAL A 457 LEU A 307	None	1.28A	17.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	6DJZ_B_GMJB301_0 (SIGMA NON-OPIOID INTRACELLULAR RECEPTOR 1)	2pfr	ARYLAMINE N-ACETYLTRANSFERASE 2 (Homo sapiens)	5 / 12	LEU A 135 SER A 127 PHE A 244 VAL A 231 LEU A 109	None UNX  A1009 ( 4.0A) None None None	1.12A	21.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	6DJZ_B_GMJB301_0 (SIGMA NON-OPIOID INTRACELLULAR RECEPTOR 1)	2rex	PLEXIN-B1 RHO-RELATED GTP-BINDING PROTEIN RHO6 (Homo sapiens; Homo sapiens)	5 / 12	LEU A1751 ILE A1777 THR A1823 VAL B  77 LEU A1772	None UNX  A  11 ( 4.8A) None None None	1.33A	20.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	6DJZ_B_GMJB301_0 (SIGMA NON-OPIOID INTRACELLULAR RECEPTOR 1)	3qxl	RAS-SPECIFIC GUANINE NUCLEOTIDE-RELEASING FACTOR RALGPS1 (Homo sapiens)	5 / 12	TYR A 249 LEU A 252 ILE A 200 HIS A 139 VAL A 101	None	1.32A	22.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	6DJZ_B_GMJB301_0 (SIGMA NON-OPIOID INTRACELLULAR RECEPTOR 1)	4p5w	CALCIUM-BINDING MITOCHONDRIAL CARRIER PROTEIN ARALAR2,CALCIUM-BIND ING MITOCHONDRIAL CARRIER PROTEIN ARALAR2 (Homo sapiens)	5 / 12	ILE A 650 PHE A  99 THR A 119 VAL A 115 LEU A  45	None	1.26A	19.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	6DJZ_B_GMJB301_0 (SIGMA NON-OPIOID INTRACELLULAR RECEPTOR 1)	5f8p	ALPHA-KETOGLUTARATE- DEPENDENT DIOXYGENASE FTO (Homo sapiens)	5 / 12	TYR A 295 LEU A 289 PHE A  69 HIS A 321 VAL A  65	AKG  A 603 (-4.6A) None None None None	1.36A	17.63
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	6DJZ_B_GMJB301_0 (SIGMA NON-OPIOID INTRACELLULAR RECEPTOR 1)	5hk2	SIGMA NON-OPIOID INTRACELLULAR RECEPTOR 1 (Homo sapiens)	7 / 12	SER A 117 PHE A 133 HIS A 154 THR A 160 VAL A 162 TRP A 164 LEU A 186	61V  A 301 (-2.9A) None 61V  A 301 ( 4.1A) None None None None	1.03A	100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	6DJZ_B_GMJB301_0 (SIGMA NON-OPIOID INTRACELLULAR RECEPTOR 1)	5hk2	SIGMA NON-OPIOID INTRACELLULAR RECEPTOR 1 (Homo sapiens)	12 / 12	TRP A  89 TYR A 103 LEU A 105 SER A 117 ILE A 124 PHE A 133 HIS A 154 THR A 160 VAL A 162 TRP A 164 THR A 181 LEU A 182	None 61V  A 301 ( 4.3A) None 61V  A 301 (-2.9A) 61V  A 301 ( 4.7A) None 61V  A 301 ( 4.1A) None None None 61V  A 301 ( 4.7A) None	0.63A	100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	6DJZ_B_GMJB301_0 (SIGMA NON-OPIOID INTRACELLULAR RECEPTOR 1)	5u1m	INSULIN RECEPTOR SUBSTRATE 1 (Homo sapiens)	5 / 12	TRP A 164 LEU A 208 ILE A 223 VAL A 166 LEU A 254	None	1.31A	17.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	6DJZ_B_GMJB301_0 (SIGMA NON-OPIOID INTRACELLULAR RECEPTOR 1)	5xgj	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM (Homo sapiens)	5 / 12	LEU A 445 ILE A 338 VAL A 376 THR A 358 LEU A 456	None	1.36A	undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	6DJZ_B_GMJB301_0 (SIGMA NON-OPIOID INTRACELLULAR RECEPTOR 1)	6bfn	INTERLEUKIN-1 RECEPTOR-ASSOCIATED KINASE 1 (Homo sapiens)	5 / 12	LEU A 241 HIS A 338 VAL A 272 THR A 258 LEU A 257	None None DL1  A 601 ( 4.8A) None None	1.27A	undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	6DJZ_B_GMJB301_1 (SIGMA NON-OPIOID INTRACELLULAR RECEPTOR 1)	2fvl	ALDO-KETO REDUCTASE FAMILY 1, MEMBER C4 (Homo sapiens)	4 / 6	TYR A 114 GLN A 190 GLU A  58 ALA A  98	None NAP  A1001 (-4.0A) None None	1.26A	21.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	6DJZ_B_GMJB301_1 (SIGMA NON-OPIOID INTRACELLULAR RECEPTOR 1)	2is7	ALDOSE REDUCTASE (Homo sapiens)	4 / 6	TYR A 107 GLN A 183 GLU A  51 ALA A  91	None NAP  A 316 (-3.7A) None None	1.26A	22.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	6DJZ_B_GMJB301_1 (SIGMA NON-OPIOID INTRACELLULAR RECEPTOR 1)	2uw2	RIBONUCLEOSIDE-DIPHO SPHATE REDUCTASE M2 SUBUNIT (Homo sapiens)	4 / 6	ASP A 138 GLN A 165 VAL A 141 ALA A 104	None	1.22A	24.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	6DJZ_B_GMJB301_1 (SIGMA NON-OPIOID INTRACELLULAR RECEPTOR 1)	2vhf	UBIQUITIN CARBOXYL-TERMINAL HYDROLASE CYLD (Homo sapiens)	4 / 6	TYR A 955 VAL A 616 GLU A 860 ALA A 884	None	1.16A	20.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	6DJZ_B_GMJB301_1 (SIGMA NON-OPIOID INTRACELLULAR RECEPTOR 1)	3mos	TRANSKETOLASE (Homo sapiens)	4 / 6	TYR A 147 ASP A 119 VAL A 120 ALA A 293	None	1.26A	17.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	6DJZ_B_GMJB301_1 (SIGMA NON-OPIOID INTRACELLULAR RECEPTOR 1)	3vpo	RIBONUCLEOSIDE-DIPHO SPHATE REDUCTASE SUBUNIT M2 (Homo sapiens)	4 / 6	ASP A 138 GLN A 165 VAL A 141 ALA A 104	None FE  A 402 (-4.5A) None None	1.12A	23.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	6DJZ_B_GMJB301_1 (SIGMA NON-OPIOID INTRACELLULAR RECEPTOR 1)	4mzv	EPITHELIAL CELL ADHESION MOLECULE (Homo sapiens)	4 / 6	ASP A 211 GLN A 175 VAL A 207 ALA A  71	None	1.17A	20.68
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	6DJZ_B_GMJB301_1 (SIGMA NON-OPIOID INTRACELLULAR RECEPTOR 1)	5hk2	SIGMA NON-OPIOID INTRACELLULAR RECEPTOR 1 (Homo sapiens)	4 / 6	ASP A 126 VAL A 152 GLU A 172 ALA A  86	61V  A 301 (-3.2A) None 61V  A 301 (-2.9A) None	1.20A	100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	6DJZ_B_GMJB301_1 (SIGMA NON-OPIOID INTRACELLULAR RECEPTOR 1)	5hk2	SIGMA NON-OPIOID INTRACELLULAR RECEPTOR 1 (Homo sapiens)	6 / 6	TYR A 120 ASP A 126 GLN A 135 VAL A 152 GLU A 172 ALA A 185	None 61V  A 301 (-3.2A) None None 61V  A 301 (-2.9A) 61V  A 301 ( 4.2A)	0.36A	100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	6DJZ_B_GMJB301_1 (SIGMA NON-OPIOID INTRACELLULAR RECEPTOR 1)	5jho	ELECTRONEUTRAL SODIUM BICARBONATE EXCHANGER 1 (Homo sapiens)	4 / 6	ASP A 328 GLN A  47 VAL A 319 GLU A 325	None	1.06A	21.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	6DJZ_B_GMJB301_1 (SIGMA NON-OPIOID INTRACELLULAR RECEPTOR 1)	5liy	ALDO-KETO REDUCTASE FAMILY 1 MEMBER B10 (Homo sapiens)	4 / 6	TYR X 108 GLN X 184 GLU X  52 ALA X  92	None NAP  X 401 (-3.8A) None None	1.20A	20.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	6DJZ_B_GMJB301_1 (SIGMA NON-OPIOID INTRACELLULAR RECEPTOR 1)	5w6m	HISTIDINE--TRNA LIGASE, CYTOPLASMIC (Homo sapiens)	4 / 6	ASP A 488 VAL A 489 GLU A 470 ALA A 416	None	1.23A	undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	6DJZ_B_GMJB301_1 (SIGMA NON-OPIOID INTRACELLULAR RECEPTOR 1)	5y3r	DNA-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT (Homo sapiens)	4 / 6	ASP C2964 GLN C3291 GLU C2960 ALA C3255	None	1.18A	4.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	6DJZ_B_GMJB301_1 (SIGMA NON-OPIOID INTRACELLULAR RECEPTOR 1)	6f2u	ALDO-KETO REDUCTASE FAMILY 1 MEMBER C3 (Homo sapiens)	4 / 6	TYR A 114 GLN A 190 GLU A  58 ALA A  98	None NAP  A 401 (-3.8A) None None	1.24A	undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	6DJZ_C_GMJC301_0 (SIGMA NON-OPIOID INTRACELLULAR RECEPTOR 1)	2coc	FYVE, RHOGEF AND PH DOMAIN CONTAINING PROTEIN 3 (Homo sapiens)	5 / 12	ALA A  28 SER A 111 THR A 100 LEU A 101 ALA A 104	None	1.11A	21.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	6DJZ_C_GMJC301_0 (SIGMA NON-OPIOID INTRACELLULAR RECEPTOR 1)	2vcy	TRANS-2-ENOYL-COA REDUCTASE (Homo sapiens)	5 / 12	ALA A 206 LEU A 340 VAL A 152 LEU A 175 ALA A 171	None	1.07A	22.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	6DJZ_C_GMJC301_0 (SIGMA NON-OPIOID INTRACELLULAR RECEPTOR 1)	3a77	INTERFERON REGULATORY FACTOR 3 (Homo sapiens)	5 / 12	ALA A 283 LEU A 281 SER A 396 VAL A 197 LEU A 226	None	1.06A	25.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	6DJZ_C_GMJC301_0 (SIGMA NON-OPIOID INTRACELLULAR RECEPTOR 1)	4hxq	ARGINASE-1 (Homo sapiens)	6 / 12	ALA A  34 LEU A  37 SER A  94 VAL A  87 THR A 300 LEU A 301	None	1.33A	21.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	6DJZ_C_GMJC301_0 (SIGMA NON-OPIOID INTRACELLULAR RECEPTOR 1)	4l27	CYSTATHIONINE BETA-SYNTHASE (Homo sapiens)	5 / 12	ALA B 158 LEU B 154 VAL B 314 LEU B 136 TYR B 163	None None HEM  B 602 (-4.1A) None None	1.12A	18.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	6DJZ_C_GMJC301_0 (SIGMA NON-OPIOID INTRACELLULAR RECEPTOR 1)	5gve	DNA TOPOISOMERASE 3-BETA-1 (Homo sapiens)	5 / 12	LEU A 301 HIS A 387 LEU A 328 ALA A 325 TYR A 409	None	1.09A	16.72
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	6DJZ_C_GMJC301_0 (SIGMA NON-OPIOID INTRACELLULAR RECEPTOR 1)	5hk2	SIGMA NON-OPIOID INTRACELLULAR RECEPTOR 1 (Homo sapiens)	9 / 12	ALA A  98 SER A 117 PHE A 133 VAL A 152 HIS A 154 VAL A 162 THR A 181 LEU A 182 TYR A 206	61V  A 301 ( 4.8A) 61V  A 301 (-2.9A) None None 61V  A 301 ( 4.1A) None 61V  A 301 ( 4.7A) None 61V  A 301 (-3.6A)	0.84A	100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	6DJZ_C_GMJC301_0 (SIGMA NON-OPIOID INTRACELLULAR RECEPTOR 1)	5hk2	SIGMA NON-OPIOID INTRACELLULAR RECEPTOR 1 (Homo sapiens)	11 / 12	MET A  93 ALA A  98 LEU A 105 SER A 117 PHE A 133 VAL A 152 HIS A 154 VAL A 162 THR A 181 ALA A 185 TYR A 206	61V  A 301 (-3.4A) 61V  A 301 ( 4.8A) None 61V  A 301 (-2.9A) None None 61V  A 301 ( 4.1A) None 61V  A 301 ( 4.7A) 61V  A 301 ( 4.2A) 61V  A 301 (-3.6A)	0.51A	100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	6DJZ_C_GMJC301_0 (SIGMA NON-OPIOID INTRACELLULAR RECEPTOR 1)	5hk2	SIGMA NON-OPIOID INTRACELLULAR RECEPTOR 1 (Homo sapiens)	9 / 12	MET A  93 ALA A  98 LEU A 105 SER A 117 VAL A 153 HIS A 154 THR A 181 ALA A 185 TYR A 206	61V  A 301 (-3.4A) 61V  A 301 ( 4.8A) None 61V  A 301 (-2.9A) None 61V  A 301 ( 4.1A) 61V  A 301 ( 4.7A) 61V  A 301 ( 4.2A) 61V  A 301 (-3.6A)	1.45A	100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	6DJZ_C_GMJC301_0 (SIGMA NON-OPIOID INTRACELLULAR RECEPTOR 1)	5nug	CYTOPLASMIC DYNEIN 1 HEAVY CHAIN 1 (Homo sapiens)	5 / 12	ALA A3512 THR A3153 LEU A3154 ALA A3157 TYR A3516	None	1.07A	3.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	6DJZ_C_GMJC301_1 (SIGMA NON-OPIOID INTRACELLULAR RECEPTOR 1)	3ctt	MALTASE-GLUCOAMYLASE (Homo sapiens)	4 / 6	LEU A  87 TYR A 263 GLN A 117 GLU A  90	None	1.25A	14.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	6DJZ_C_GMJC301_1 (SIGMA NON-OPIOID INTRACELLULAR RECEPTOR 1)	4a35	MITOCHONDRIAL ENOLASE SUPERFAMILY MEMBER 1 (Homo sapiens)	4 / 6	LEU A 326 TYR A 194 ASP A 254 GLU A 280	None None MG  A1445 (-2.6A) MG  A1445 (-3.0A)	1.48A	18.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	6DJZ_C_GMJC301_1 (SIGMA NON-OPIOID INTRACELLULAR RECEPTOR 1)	4bla	MALTOSE-BINDING PERIPLASMIC PROTEIN, SUPPRESSOR OF FUSED HOMOLOG (Escherichia coli; Homo sapiens)	4 / 6	LEU A 464 TYR A 385 ASP A 522 GLN A 526	None	1.41A	16.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	6DJZ_C_GMJC301_1 (SIGMA NON-OPIOID INTRACELLULAR RECEPTOR 1)	4cmn	INOSITOL POLYPHOSPHATE 5-PHOSPHATASE OCRL-1 (Homo sapiens)	4 / 6	LEU A 376 TYR A 513 ASP A 451 GLN A 445	None	1.50A	20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	6DJZ_C_GMJC301_1 (SIGMA NON-OPIOID INTRACELLULAR RECEPTOR 1)	4fdj	N-ACETYLGALACTOSAMIN E-6-SULFATASE (Homo sapiens)	4 / 6	TRP A 141 LEU A 128 GLN A 148 GLU A 126	None	1.41A	21.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	6DJZ_C_GMJC301_1 (SIGMA NON-OPIOID INTRACELLULAR RECEPTOR 1)	4iqr	HEPATOCYTE NUCLEAR FACTOR 4-ALPHA (Homo sapiens)	4 / 6	LEU A 329 TYR A 319 ASP A 273 GLU A 276	None	1.24A	21.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	6DJZ_C_GMJC301_1 (SIGMA NON-OPIOID INTRACELLULAR RECEPTOR 1)	4mh0	RAP GUANINE NUCLEOTIDE EXCHANGE FACTOR 4 RAS-RELATED PROTEIN RAP-1B (Mus musculus; Homo sapiens)	4 / 6	LEU E 893 ASP R  38 GLN R  43 GLU R  37	None	1.25A	14.68
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	6DJZ_C_GMJC301_1 (SIGMA NON-OPIOID INTRACELLULAR RECEPTOR 1)	5hk2	SIGMA NON-OPIOID INTRACELLULAR RECEPTOR 1 (Homo sapiens)	6 / 6	TRP A  89 LEU A  95 TYR A 120 ASP A 126 GLN A 135 GLU A 172	None None None 61V  A 301 (-3.2A) None 61V  A 301 (-2.9A)	0.34A	100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	6DJZ_C_GMJC301_1 (SIGMA NON-OPIOID INTRACELLULAR RECEPTOR 1)	5ogs	WD REPEAT AND HMG-BOX DNA-BINDING PROTEIN 1 (Homo sapiens)	4 / 6	LEU A 440 ASP A 534 GLN A 531 GLU A 502	None	1.49A	19.01