POTENTIAL TARGETS FROM HUMAN (RESULTS FROM SUB-STRUCTURAL SIMILARITY SEARCHES)
1) User may click on the DrReposER ID (the second column) to get information on the binding sites and drug molecule.
2) Click View (the second last column) to view matched residues and superposition in the NGL viewer (upper right part).
3) User may also click on the Dock (the last column) to get script for molecular docking in UCSF Chimera through AutoDock Vina.

DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EQB_A_GLYA1292_0
(SERINE
HYDROXYMETHYLTRANSFE
RASE)		2cy7 CYSTEINE PROTEASE
APG4B
(Homo
sapiens)		4 / 8SER A 262
HIS A 280
TYR A 276
PHE A 266
None
0.97A20.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EQB_A_GLYA1292_0
(SERINE
HYDROXYMETHYLTRANSFE
RASE)		2n03 PLECTIN
(Homo
sapiens)		4 / 8HIS A4401
SER A4400
HIS A4395
TYR A4517
None
1.32A19.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EQB_A_GLYA1292_0
(SERINE
HYDROXYMETHYLTRANSFE
RASE)		4b92 DIHYDROPYRIMIDINASE-
RELATED PROTEIN 5
(Homo
sapiens)		4 / 8SER A  66
HIS A 191
HIS A 100
ARG A 189
None
1.16A23.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EQB_A_GLYA1292_0
(SERINE
HYDROXYMETHYLTRANSFE
RASE)		4u7m LEUCINE-RICH REPEATS
AND
IMMUNOGLOBULIN-LIKE
DOMAINS PROTEIN 1
(Homo
sapiens)		4 / 8SER A 521
HIS A 582
SER A 524
LYS A 494
None
1.16A21.31
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1EQB_A_GLYA1292_0
(SERINE
HYDROXYMETHYLTRANSFE
RASE)		5v7i SERINE
HYDROXYMETHYLTRANSFE
RASE, MITOCHONDRIAL
(Homo
sapiens)		5 / 8SER A  76
HIS A 171
SER A 226
HIS A 254
ARG A 425
None
LLP  A 280 (-3.3A)
LLP  A 280 (-3.4A)
LLP  A 280 ( 4.0A)
8Z1  A 601 ( 3.8A)
0.25A44.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EQB_A_GLYA1292_0
(SERINE
HYDROXYMETHYLTRANSFE
RASE)		5vad BIFUNCTIONAL
GLUTAMATE/PROLINE--T
RNA LIGASE
(Homo
sapiens)		4 / 8SER A1272
SER A1122
HIS A1173
PHE A1216
PRO  A1602 (-3.3A)
None
PRO  A1602 ( 4.5A)
PRO  A1602 (-4.3A)
1.13A22.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EQB_A_GLYA1292_0
(SERINE
HYDROXYMETHYLTRANSFE
RASE)		5xtd NADH-UBIQUINONE
OXIDOREDUCTASE CHAIN
1
(Homo
sapiens)		4 / 8SER s 178
SER s 152
HIS s 304
PHE s 242
None
1.07A20.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EQB_B_GLYB2292_0
(SERINE
HYDROXYMETHYLTRANSFE
RASE)		2cy7 CYSTEINE PROTEASE
APG4B
(Homo
sapiens)		4 / 8TYR A 276
PHE A 266
SER A 262
HIS A 280
None
0.95A20.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EQB_B_GLYB2292_0
(SERINE
HYDROXYMETHYLTRANSFE
RASE)		2n03 PLECTIN
(Homo
sapiens)		4 / 8TYR A4517
HIS A4401
SER A4400
HIS A4395
None
1.31A19.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EQB_B_GLYB2292_0
(SERINE
HYDROXYMETHYLTRANSFE
RASE)		4b92 DIHYDROPYRIMIDINASE-
RELATED PROTEIN 5
(Homo
sapiens)		4 / 8SER A  66
HIS A 191
HIS A 100
ARG A 189
None
1.14A23.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EQB_B_GLYB2292_0
(SERINE
HYDROXYMETHYLTRANSFE
RASE)		4u7m LEUCINE-RICH REPEATS
AND
IMMUNOGLOBULIN-LIKE
DOMAINS PROTEIN 1
(Homo
sapiens)		4 / 8SER A 521
HIS A 582
SER A 524
LYS A 494
None
1.16A21.31
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1EQB_B_GLYB2292_0
(SERINE
HYDROXYMETHYLTRANSFE
RASE)		5v7i SERINE
HYDROXYMETHYLTRANSFE
RASE, MITOCHONDRIAL
(Homo
sapiens)		5 / 8SER A  76
HIS A 171
SER A 226
HIS A 254
ARG A 425
None
LLP  A 280 (-3.3A)
LLP  A 280 (-3.4A)
LLP  A 280 ( 4.0A)
8Z1  A 601 ( 3.8A)
0.25A44.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EQB_B_GLYB2292_0
(SERINE
HYDROXYMETHYLTRANSFE
RASE)		5vad BIFUNCTIONAL
GLUTAMATE/PROLINE--T
RNA LIGASE
(Homo
sapiens)		4 / 8PHE A1216
SER A1272
SER A1122
HIS A1173
PRO  A1602 (-4.3A)
PRO  A1602 (-3.3A)
None
PRO  A1602 ( 4.5A)
1.13A22.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EQB_B_GLYB2292_0
(SERINE
HYDROXYMETHYLTRANSFE
RASE)		5xtd NADH-UBIQUINONE
OXIDOREDUCTASE CHAIN
1
(Homo
sapiens)		4 / 8PHE s 242
SER s 178
SER s 152
HIS s 304
None
1.09A20.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EQB_C_GLYC3292_0
(SERINE
HYDROXYMETHYLTRANSFE
RASE)		2cy7 CYSTEINE PROTEASE
APG4B
(Homo
sapiens)		4 / 8SER A 262
HIS A 280
TYR A 276
PHE A 266
None
0.97A20.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EQB_C_GLYC3292_0
(SERINE
HYDROXYMETHYLTRANSFE
RASE)		2n03 PLECTIN
(Homo
sapiens)		4 / 8HIS A4401
SER A4400
HIS A4395
TYR A4517
None
1.31A19.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EQB_C_GLYC3292_0
(SERINE
HYDROXYMETHYLTRANSFE
RASE)		4b92 DIHYDROPYRIMIDINASE-
RELATED PROTEIN 5
(Homo
sapiens)		4 / 8SER A  66
HIS A 191
HIS A 100
ARG A 189
None
1.16A23.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EQB_C_GLYC3292_0
(SERINE
HYDROXYMETHYLTRANSFE
RASE)		4u7m LEUCINE-RICH REPEATS
AND
IMMUNOGLOBULIN-LIKE
DOMAINS PROTEIN 1
(Homo
sapiens)		4 / 8SER A 521
HIS A 582
SER A 524
LYS A 494
None
1.16A21.31
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1EQB_C_GLYC3292_0
(SERINE
HYDROXYMETHYLTRANSFE
RASE)		5v7i SERINE
HYDROXYMETHYLTRANSFE
RASE, MITOCHONDRIAL
(Homo
sapiens)		5 / 8SER A  76
HIS A 171
SER A 226
HIS A 254
ARG A 425
None
LLP  A 280 (-3.3A)
LLP  A 280 (-3.4A)
LLP  A 280 ( 4.0A)
8Z1  A 601 ( 3.8A)
0.24A44.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EQB_C_GLYC3292_0
(SERINE
HYDROXYMETHYLTRANSFE
RASE)		5vad BIFUNCTIONAL
GLUTAMATE/PROLINE--T
RNA LIGASE
(Homo
sapiens)		4 / 8SER A1272
SER A1122
HIS A1173
PHE A1216
PRO  A1602 (-3.3A)
None
PRO  A1602 ( 4.5A)
PRO  A1602 (-4.3A)
1.14A22.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EQB_C_GLYC3292_0
(SERINE
HYDROXYMETHYLTRANSFE
RASE)		5xtd NADH-UBIQUINONE
OXIDOREDUCTASE CHAIN
1
(Homo
sapiens)		4 / 8SER s 178
SER s 152
HIS s 304
PHE s 242
None
1.07A20.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EQB_D_GLYD4292_0
(SERINE
HYDROXYMETHYLTRANSFE
RASE)		2cy7 CYSTEINE PROTEASE
APG4B
(Homo
sapiens)		4 / 8TYR A 276
PHE A 266
SER A 262
HIS A 280
None
0.95A20.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EQB_D_GLYD4292_0
(SERINE
HYDROXYMETHYLTRANSFE
RASE)		2n03 PLECTIN
(Homo
sapiens)		4 / 8TYR A4517
HIS A4401
SER A4400
HIS A4395
None
1.31A19.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EQB_D_GLYD4292_0
(SERINE
HYDROXYMETHYLTRANSFE
RASE)		4b92 DIHYDROPYRIMIDINASE-
RELATED PROTEIN 5
(Homo
sapiens)		4 / 8SER A  66
HIS A 191
HIS A 100
ARG A 189
None
1.15A23.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EQB_D_GLYD4292_0
(SERINE
HYDROXYMETHYLTRANSFE
RASE)		4u7m LEUCINE-RICH REPEATS
AND
IMMUNOGLOBULIN-LIKE
DOMAINS PROTEIN 1
(Homo
sapiens)		4 / 8SER A 521
HIS A 582
SER A 524
LYS A 494
None
1.16A21.31
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1EQB_D_GLYD4292_0
(SERINE
HYDROXYMETHYLTRANSFE
RASE)		5v7i SERINE
HYDROXYMETHYLTRANSFE
RASE, MITOCHONDRIAL
(Homo
sapiens)		5 / 8SER A  76
HIS A 171
SER A 226
HIS A 254
ARG A 425
None
LLP  A 280 (-3.3A)
LLP  A 280 (-3.4A)
LLP  A 280 ( 4.0A)
8Z1  A 601 ( 3.8A)
0.25A44.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EQB_D_GLYD4292_0
(SERINE
HYDROXYMETHYLTRANSFE
RASE)		5vad BIFUNCTIONAL
GLUTAMATE/PROLINE--T
RNA LIGASE
(Homo
sapiens)		4 / 8PHE A1216
SER A1272
SER A1122
HIS A1173
PRO  A1602 (-4.3A)
PRO  A1602 (-3.3A)
None
PRO  A1602 ( 4.5A)
1.13A22.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EQB_D_GLYD4292_0
(SERINE
HYDROXYMETHYLTRANSFE
RASE)		5xtd NADH-UBIQUINONE
OXIDOREDUCTASE CHAIN
1
(Homo
sapiens)		4 / 8PHE s 242
SER s 178
SER s 152
HIS s 304
None
1.08A20.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2RLC_A_GLYA333_0
(CHOLOYLGLYCINE
HYDROLASE)		1fpr PROTEIN-TYROSINE
PHOSPHATASE 1C
(Homo
sapiens)		3 / 3ASN A 276
ASN A 305
ARG A 497
None
0.86A19.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2RLC_A_GLYA333_0
(CHOLOYLGLYCINE
HYDROLASE)		1l8k T-CELL
PROTEIN-TYROSINE
PHOSPHATASE
(Homo
sapiens)		3 / 3ASN A  46
ASN A  70
ARG A 255
None
0.74A23.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2RLC_A_GLYA333_0
(CHOLOYLGLYCINE
HYDROLASE)		1lar PROTEIN (LAR)
(Homo
sapiens)		3 / 3ASN A1353
ASN A1381
ARG A1561
None
0.73A19.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2RLC_A_GLYA333_0
(CHOLOYLGLYCINE
HYDROLASE)		1lar PROTEIN (LAR)
(Homo
sapiens)		3 / 3ASN A1642
ASN A1670
ARG A1852
None
0.72A19.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2RLC_A_GLYA333_0
(CHOLOYLGLYCINE
HYDROLASE)		1rpm RECEPTOR PROTEIN
TYROSINE PHOSPHATASE
MU
(Homo
sapiens)		3 / 3ASN A 927
ASN A 955
ARG A1134
None
0.78A18.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2RLC_A_GLYA333_0
(CHOLOYLGLYCINE
HYDROLASE)		1wch PROTEIN TYROSINE
PHOSPHATASE,
NON-RECEPTOR TYPE 13
(Homo
sapiens)		3 / 3ASN A2241
ASN A2264
ARG A2447
None
0.68A20.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2RLC_A_GLYA333_0
(CHOLOYLGLYCINE
HYDROLASE)		1ygu LEUKOCYTE COMMON
ANTIGEN
(Homo
sapiens)		3 / 3ASN A 656
ASN A 684
ARG A 867
None
0.66A18.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2RLC_A_GLYA333_0
(CHOLOYLGLYCINE
HYDROLASE)		1ygu LEUKOCYTE COMMON
ANTIGEN
(Homo
sapiens)		3 / 3ASN A 947
ASN A 994
ARG A1183
None
0.77A18.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2RLC_A_GLYA333_0
(CHOLOYLGLYCINE
HYDROLASE)		2a8b RECEPTOR-TYPE
TYROSINE-PROTEIN
PHOSPHATASE R
(Homo
sapiens)		3 / 3ASN A 419
ASN A 448
ARG A 627
None
0.78A21.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2RLC_A_GLYA333_0
(CHOLOYLGLYCINE
HYDROLASE)		2b3o TYROSINE-PROTEIN
PHOSPHATASE,
NON-RECEPTOR TYPE 6
(Homo
sapiens)		3 / 3ASN A 274
ASN A 303
ARG A 495
None
0.85A22.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2RLC_A_GLYA333_0
(CHOLOYLGLYCINE
HYDROLASE)		2b49 PROTEIN TYROSINE
PHOSPHATASE,
NON-RECEPTOR TYPE 3
(Homo
sapiens)		3 / 3ASN A 674
ASN A 697
ARG A 881
None
0.67A20.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2RLC_A_GLYA333_0
(CHOLOYLGLYCINE
HYDROLASE)		2bv5 TYROSINE-PROTEIN
PHOSPHATASE,
NON-RECEPTOR TYPE 5
(Homo
sapiens)		3 / 3ASN A 302
ASN A 331
ARG A 511
None
0.82A19.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2RLC_A_GLYA333_0
(CHOLOYLGLYCINE
HYDROLASE)		2c7s RECEPTOR-TYPE
TYROSINE-PROTEIN
PHOSPHATASE KAPPA
(Homo
sapiens)		3 / 3ASN A 915
ASN A 943
ARG A1122
None
0.77A21.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2RLC_A_GLYA333_0
(CHOLOYLGLYCINE
HYDROLASE)		2cfv HUMAN PROTEIN
TYROSINE PHOSPHATASE
RECEPTOR TYPE J
(Homo
sapiens)		3 / 3ASN A1069
ASN A1096
ARG A1278
None
0.70A21.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2RLC_A_GLYA333_0
(CHOLOYLGLYCINE
HYDROLASE)		2gjt RECEPTOR-TYPE
TYROSINE-PROTEIN
PHOSPHATASE PTPRO
(Homo
sapiens)		3 / 3ASN A 966
ASN A 994
ARG A1175
None
0.68A22.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2RLC_A_GLYA333_0
(CHOLOYLGLYCINE
HYDROLASE)		2h03 PROTEIN TYROSINE
PHOSPHATASE,
RECEPTOR TYPE, B,
(Homo
sapiens)		3 / 3ASN A1731
ASN A1759
ARG A1943
None
0.65A19.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2RLC_A_GLYA333_0
(CHOLOYLGLYCINE
HYDROLASE)		2i1y RECEPTOR-TYPE
TYROSINE-PROTEIN
PHOSPHATASE
(Homo
sapiens)		3 / 3ASN A 738
ASN A 766
ARG A 949
None
0.60A22.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2RLC_A_GLYA333_0
(CHOLOYLGLYCINE
HYDROLASE)		2i75 TYROSINE-PROTEIN
PHOSPHATASE
NON-RECEPTOR TYPE 4
(Homo
sapiens)		3 / 3ASN A 683
ASN A 706
ARG A 891
None
0.71A22.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2RLC_A_GLYA333_0
(CHOLOYLGLYCINE
HYDROLASE)		2jjd RECEPTOR-TYPE
TYROSINE-PROTEIN
PHOSPHATASE EPSILON
(Homo
sapiens)		3 / 3ASN A 163
ASN A 191
ARG A 374
None
0.67A18.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2RLC_A_GLYA333_0
(CHOLOYLGLYCINE
HYDROLASE)		2nlk PROTEIN TYROSINE
PHOSPHATASE,
RECEPTOR TYPE, G
VARIANT (FRAGMENT)
(Homo
sapiens)		3 / 3ASN A 878
ASN A 908
ARG A1099
None
0.76A20.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2RLC_A_GLYA333_0
(CHOLOYLGLYCINE
HYDROLASE)		2nlk PROTEIN TYROSINE
PHOSPHATASE,
RECEPTOR TYPE, G
VARIANT (FRAGMENT)
(Homo
sapiens)		3 / 3ASN A1179
ASN A1207
ARG A1390
None
0.83A20.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2RLC_A_GLYA333_0
(CHOLOYLGLYCINE
HYDROLASE)		2ooq RECEPTOR-TYPE
TYROSINE-PROTEIN
PHOSPHATASE T
(Homo
sapiens)		3 / 3ASN A 938
ASN A 966
ARG A1145
None
0.75A20.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2RLC_A_GLYA333_0
(CHOLOYLGLYCINE
HYDROLASE)		2pa5 TYROSINE-PROTEIN
PHOSPHATASE
NON-RECEPTOR TYPE 9
(Homo
sapiens)		3 / 3ASN A 331
ASN A 359
ARG A 554
None
0.79A22.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2RLC_A_GLYA333_0
(CHOLOYLGLYCINE
HYDROLASE)		2qep RECEPTOR-TYPE
TYROSINE-PROTEIN
PHOSPHATASE N2
(Homo
sapiens)		3 / 3ASN A 774
ASN A 802
ARG A 985
None
0.72A20.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2RLC_A_GLYA333_0
(CHOLOYLGLYCINE
HYDROLASE)		2zu6 EUKARYOTIC
INITIATION FACTOR
4A-I
(Homo
sapiens)		3 / 3ASN A 352
ASN A 355
ARG A 334
None
0.70A22.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2RLC_A_GLYA333_0
(CHOLOYLGLYCINE
HYDROLASE)		3a5k TYROSINE-PROTEIN
PHOSPHATASE
NON-RECEPTOR TYPE 1
(Homo
sapiens)		3 / 3ASN A  44
ASN A  68
ARG A 257
None
0.71A21.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2RLC_A_GLYA333_0
(CHOLOYLGLYCINE
HYDROLASE)		3h2x TYROSINE-PROTEIN
PHOSPHATASE
NON-RECEPTOR TYPE 22
(Homo
sapiens)		3 / 3ASN A  58
ASN A  86
ARG A 269
None
0.74A22.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2RLC_A_GLYA333_0
(CHOLOYLGLYCINE
HYDROLASE)		3ps5 TYROSINE-PROTEIN
PHOSPHATASE
NON-RECEPTOR TYPE 6
(Homo
sapiens)		3 / 3ASN A 274
ASN A 303
ARG A 495
None
0.75A21.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2RLC_A_GLYA333_0
(CHOLOYLGLYCINE
HYDROLASE)		3qci RECEPTOR-TYPE
TYROSINE-PROTEIN
PHOSPHATASE GAMMA
(Homo
sapiens)		3 / 3ASN A 878
ASN A 908
ARG A1099
None
0.76A21.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2RLC_A_GLYA333_0
(CHOLOYLGLYCINE
HYDROLASE)		4bpc RECEPTOR-TYPE
TYROSINE-PROTEIN
PHOSPHATASE S
(Homo
sapiens)		3 / 3ASN A1420
ASN A1448
ARG A1628
None
0.73A19.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2RLC_A_GLYA333_0
(CHOLOYLGLYCINE
HYDROLASE)		4bpc RECEPTOR-TYPE
TYROSINE-PROTEIN
PHOSPHATASE S
(Homo
sapiens)		3 / 3ASN A1709
ASN A1737
ARG A1919
None
0.69A19.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2RLC_A_GLYA333_0
(CHOLOYLGLYCINE
HYDROLASE)		4ikc PHOSPHOTIDYLINOSITOL
PHOSPHATASE PTPRQ
(Homo
sapiens)		3 / 3ASN A2710
ASN A2738
ARG A2918
None
0.68A21.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2RLC_A_GLYA333_0
(CHOLOYLGLYCINE
HYDROLASE)		4nnd TYROSINE-PROTEIN
PHOSPHATASE
NON-RECEPTOR TYPE 18
(Homo
sapiens)		3 / 3ASN A  60
ASN A  88
ARG A 271
None
0.72A20.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2RLC_A_GLYA333_0
(CHOLOYLGLYCINE
HYDROLASE)		4pj3 INTRON-BINDING
PROTEIN AQUARIUS
(Homo
sapiens)		3 / 3ASN A 155
ASN A 456
ARG A1125
None
0.79A11.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2RLC_A_GLYA333_0
(CHOLOYLGLYCINE
HYDROLASE)		4pvg TYROSINE-PROTEIN
PHOSPHATASE
NON-RECEPTOR TYPE 11
(Homo
sapiens)		3 / 3ASN A 277
ASN A 306
ARG A 501
None
0.76A21.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2RLC_A_GLYA333_0
(CHOLOYLGLYCINE
HYDROLASE)		4z94 GELSOLIN,
TROPOMODULIN-1,
LEIOMODIN-1 CHIMERA
(Homo
sapiens)		3 / 3ASN G  54
ASN G  56
ARG G  91
None
0.91A22.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2RLC_A_GLYA333_0
(CHOLOYLGLYCINE
HYDROLASE)		5h08 RECEPTOR-TYPE
TYROSINE-PROTEIN
PHOSPHATASE ZETA
(Homo
sapiens)		3 / 3ASN A1754
ASN A1784
ARG A1972
None
0.80A21.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2RLC_A_GLYA333_0
(CHOLOYLGLYCINE
HYDROLASE)		5hde TYROSINE-PROTEIN
PHOSPHATASE
NON-RECEPTOR TYPE 12
(Homo
sapiens)		3 / 3ASN A  62
ASN A  90
ARG A 273
None
0.70A22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2RLC_A_GLYA333_0
(CHOLOYLGLYCINE
HYDROLASE)		5i6v TYROSINE-PROTEIN
PHOSPHATASE
NON-RECEPTOR TYPE 11
(Homo
sapiens)		3 / 3ASN A 277
ASN A 306
ARG A 501
None
0.68A18.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VMY_A_GLYA502_0
(SERINE
HYDROXYMETHYLTRANSFE
RASE)		1wao SERINE/THREONINE
PROTEIN PHOSPHATASE
5
(Homo
sapiens)		4 / 7HIS 1 427
HIS 1 304
ARG 1 275
TYR 1  78
 MN  1 601 (-3.4A)
None
MN  1 602 ( 4.7A)
None
1.14A23.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VMY_A_GLYA502_0
(SERINE
HYDROXYMETHYLTRANSFE
RASE)		2fy2 CHOLINE
O-ACETYLTRANSFERASE
(Homo
sapiens)		4 / 7SER A 532
ARG A 453
TYR A 529
TYR A  28
None
1.45A21.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VMY_A_GLYA502_0
(SERINE
HYDROXYMETHYLTRANSFE
RASE)		4b92 DIHYDROPYRIMIDINASE-
RELATED PROTEIN 5
(Homo
sapiens)		4 / 7SER A  66
HIS A 191
HIS A 100
ARG A 189
None
1.18A21.70
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2VMY_A_GLYA502_0
(SERINE
HYDROXYMETHYLTRANSFE
RASE)		5v7i SERINE
HYDROXYMETHYLTRANSFE
RASE, MITOCHONDRIAL
(Homo
sapiens)		4 / 7SER A  76
HIS A 171
HIS A 254
ARG A 425
None
LLP  A 280 (-3.3A)
LLP  A 280 ( 4.0A)
8Z1  A 601 ( 3.8A)
0.27A43.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VMY_A_GLYA502_0
(SERINE
HYDROXYMETHYLTRANSFE
RASE)		6b9j FAB VV138 HEAVY
CHAIN
(Homo
sapiens)		4 / 7SER H 100
HIS H 105
LYS H  98
TYR H  32
None
1.49A19.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VMY_B_GLYB502_0
(SERINE
HYDROXYMETHYLTRANSFE
RASE)		1pl0 BIFUNCTIONAL PURINE
BIOSYNTHESIS PROTEIN
PURH
(Homo
sapiens)		4 / 8TYR A 104
SER A  12
SER A  10
LYS A  14
XMP  A 901 (-4.1A)
XMP  A 901 (-2.6A)
XMP  A 901 (-3.0A)
XMP  A 901 (-3.4A)
1.34A21.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VMY_B_GLYB502_0
(SERINE
HYDROXYMETHYLTRANSFE
RASE)		1wao SERINE/THREONINE
PROTEIN PHOSPHATASE
5
(Homo
sapiens)		4 / 8TYR 1  78
HIS 1 427
HIS 1 304
ARG 1 275
None
MN  1 601 (-3.4A)
None
MN  1 602 ( 4.7A)
1.13A23.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VMY_B_GLYB502_0
(SERINE
HYDROXYMETHYLTRANSFE
RASE)		2n03 PLECTIN
(Homo
sapiens)		4 / 8TYR A4517
HIS A4401
SER A4400
HIS A4395
None
1.33A20.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VMY_B_GLYB502_0
(SERINE
HYDROXYMETHYLTRANSFE
RASE)		4b90 DIHYDROPYRIMIDINASE-
RELATED PROTEIN 5
(Homo
sapiens)		4 / 8SER A  66
HIS A 191
HIS A 100
ARG A 189
None
1.10A21.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VMY_B_GLYB502_0
(SERINE
HYDROXYMETHYLTRANSFE
RASE)		4b92 DIHYDROPYRIMIDINASE-
RELATED PROTEIN 5
(Homo
sapiens)		4 / 8SER A  66
HIS A 191
HIS A 100
ARG A 189
None
1.08A21.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VMY_B_GLYB502_0
(SERINE
HYDROXYMETHYLTRANSFE
RASE)		4rgw TRANSCRIPTION
INITIATION FACTOR
TFIID SUBUNIT 1
(Homo
sapiens)		4 / 8TYR A 909
HIS A 858
SER A 857
HIS A 627
None
1.25A20.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VMY_B_GLYB502_0
(SERINE
HYDROXYMETHYLTRANSFE
RASE)		4u7m LEUCINE-RICH REPEATS
AND
IMMUNOGLOBULIN-LIKE
DOMAINS PROTEIN 1
(Homo
sapiens)		4 / 8SER A 521
HIS A 582
SER A 524
LYS A 494
None
1.25A22.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VMY_B_GLYB502_0
(SERINE
HYDROXYMETHYLTRANSFE
RASE)		5fur TRANSCRIPTION
INITIATION FACTOR
TFIID SUBUNIT 1
(Homo
sapiens)		4 / 8TYR G 909
HIS G 858
SER G 857
HIS G 627
None
1.25A11.09
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2VMY_B_GLYB502_0
(SERINE
HYDROXYMETHYLTRANSFE
RASE)		5v7i SERINE
HYDROXYMETHYLTRANSFE
RASE, MITOCHONDRIAL
(Homo
sapiens)		5 / 8SER A  76
HIS A 171
SER A 226
HIS A 254
ARG A 425
None
LLP  A 280 (-3.3A)
LLP  A 280 (-3.4A)
LLP  A 280 ( 4.0A)
8Z1  A 601 ( 3.8A)
0.33A43.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YS6_A_GLYA431_0
(PHOSPHORIBOSYLGLYCIN
AMIDE SYNTHETASE)		1saw HYPOTHETICAL PROTEIN
FLJ36880
(Homo
sapiens)		4 / 8ASP A 102
LYS A 123
GLY A 191
GLU A  73
 MG  A 225 (-3.2A)
MG  A 225 (-3.6A)
MG  A 225 ( 4.6A)
MG  A 225 (-2.7A)
0.81A20.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YS6_A_GLYA431_0
(PHOSPHORIBOSYLGLYCIN
AMIDE SYNTHETASE)		2kk6 PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE FER
(Homo
sapiens)		4 / 8TYR A  51
GLY A  49
PRO A  48
GLU A  43
None
0.94A13.94
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2YS6_A_GLYA431_0
(PHOSPHORIBOSYLGLYCIN
AMIDE SYNTHETASE)		2qk4 TRIFUNCTIONAL PURINE
BIOSYNTHETIC PROTEIN
ADENOSINE-3
(Homo
sapiens)		6 / 8ASP A 217
LYS A 219
ARG A 292
GLY A 294
PRO A 296
GLU A 297
None
None
SO4  A 701 (-4.1A)
None
None
None
1.06A49.46
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2YS6_A_GLYA431_0
(PHOSPHORIBOSYLGLYCIN
AMIDE SYNTHETASE)		2qk4 TRIFUNCTIONAL PURINE
BIOSYNTHETIC PROTEIN
ADENOSINE-3
(Homo
sapiens)		6 / 8ASP A 217
LYS A 219
TYR A 274
ARG A 292
GLY A 294
GLU A 297
None
None
None
SO4  A 701 (-4.1A)
None
None
1.22A49.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YS6_A_GLYA431_0
(PHOSPHORIBOSYLGLYCIN
AMIDE SYNTHETASE)		2wd9 ACYL-COENZYME A
SYNTHETASE ACSM2A,
MITOCHONDRIAL
(Homo
sapiens)		4 / 8TYR A 235
ASN A  45
GLY A 211
GLU A 214
None
0.97A23.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YS6_A_GLYA431_0
(PHOSPHORIBOSYLGLYCIN
AMIDE SYNTHETASE)		3fed GLUTAMATE
CARBOXYPEPTIDASE III
(Homo
sapiens)		4 / 8TYR A 677
ASN A 252
GLY A 253
GLU A 512
None
0.95A21.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YS6_A_GLYA431_0
(PHOSPHORIBOSYLGLYCIN
AMIDE SYNTHETASE)		3n3k UBIQUITIN
CARBOXYL-TERMINAL
HYDROLASE 8
(Homo
sapiens)		4 / 8LYS A 891
ASN A 815
GLY A 821
GLU A 882
None
0.98A23.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YS6_A_GLYA431_0
(PHOSPHORIBOSYLGLYCIN
AMIDE SYNTHETASE)		4j6p LOW AFFINITY
IMMUNOGLOBULIN
EPSILON FC RECEPTOR
(Homo
sapiens)		4 / 8ASP A 270
GLY A 248
PRO A 250
GLU A 249
None
0.97A18.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YS6_A_GLYA431_0
(PHOSPHORIBOSYLGLYCIN
AMIDE SYNTHETASE)		5ao0 DEOXYNUCLEOSIDE
TRIPHOSPHATE
TRIPHOSPHOHYDROLASE
SAMHD1
(Homo
sapiens)		4 / 8ASN A 527
ARG A 339
PRO A 187
GLU A 188
None
1.01A22.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Z0A_A_GLYA73_0
(NONSTRUCTURAL
PROTEIN 1)		1xtj PROBABLE
ATP-DEPENDENT RNA
HELICASE P47
(Homo
sapiens)		4 / 5GLN A 305
ALA A 302
GLN A 298
ILE A 301
None
1.24A12.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Z0A_A_GLYA73_0
(NONSTRUCTURAL
PROTEIN 1)		2a2a DEATH-ASSOCIATED
PROTEIN KINASE 2
(Homo
sapiens)		4 / 5ALA A 214
GLN A 299
ILE A 209
ARG A 303
None
1.10A12.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Z0A_A_GLYA73_0
(NONSTRUCTURAL
PROTEIN 1)		2mh9 BLOOM SYNDROME
PROTEIN
(Homo
sapiens)		4 / 5ALA A  58
GLN A  61
ILE A  60
ARG A  32
None
1.33A22.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Z0A_A_GLYA73_0
(NONSTRUCTURAL
PROTEIN 1)		2o4x STAPHYLOCOCCAL
NUCLEASE
DOMAIN-CONTAINING
PROTEIN 1
(Homo
sapiens)		4 / 5ALA B 768
GLN B 767
ILE B 739
ARG B 722
None
1.47A19.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Z0A_A_GLYA73_0
(NONSTRUCTURAL
PROTEIN 1)		2qfz TBC1 DOMAIN FAMILY
MEMBER 22A
(Homo
sapiens)		4 / 5GLN A 320
GLN A 279
ILE A 282
ARG A 278
UNX  A1012 (-3.1A)
None
None
None
1.34A14.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Z0A_A_GLYA73_0
(NONSTRUCTURAL
PROTEIN 1)		3bdl STAPHYLOCOCCAL
NUCLEASE
DOMAIN-CONTAINING
PROTEIN 1
(Homo
sapiens)		4 / 5ALA A 768
GLN A 767
ILE A 739
ARG A 722
None
1.43A11.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Z0A_A_GLYA73_0
(NONSTRUCTURAL
PROTEIN 1)		3eh1 PROTEIN TRANSPORT
PROTEIN SEC24B
(Homo
sapiens)		4 / 5GLN A1084
ALA A1101
GLN A1104
ILE A1105
None
1.46A8.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Z0A_A_GLYA73_0
(NONSTRUCTURAL
PROTEIN 1)		3lhr ZINC FINGER PROTEIN
24
(Homo
sapiens)		4 / 5GLN A  56
ALA A  59
GLN A  66
ILE A  60
None
1.17A21.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Z0A_A_GLYA73_0
(NONSTRUCTURAL
PROTEIN 1)		3rl2 HLA CLASS I
HISTOCOMPATIBILITY
ANTIGEN, A-3 ALPHA
CHAIN
(Homo
sapiens)		4 / 5ALA A 140
GLN A 141
ILE A 142
ARG A 145
None
1.43A14.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Z0A_A_GLYA73_0
(NONSTRUCTURAL
PROTEIN 1)		3wap AUTOPHAGY-RELATED
PROTEIN 13,
MICROTUBULE-ASSOCIAT
ED PROTEINS 1A/1B
LIGHT CHAIN 3C
(Homo
sapiens)		4 / 5ALA A 111
GLN A  71
ILE A  46
ARG A  39
None
1.17A21.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Z0A_A_GLYA73_0
(NONSTRUCTURAL
PROTEIN 1)		4f9o HEXOKINASE-1
(Homo
sapiens)		4 / 5GLN A 799
ALA A 802
GLN A 805
ILE A 803
None
1.39A7.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Z0A_A_GLYA73_0
(NONSTRUCTURAL
PROTEIN 1)		4f9o HEXOKINASE-1
(Homo
sapiens)		4 / 5GLN A 799
ALA A 802
GLN A 806
ILE A 803
None
1.24A7.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Z0A_A_GLYA73_0
(NONSTRUCTURAL
PROTEIN 1)		5dpw MICROTUBULE-ASSOCIAT
ED PROTEINS 1A/1B
LIGHT CHAIN 3C
(Homo
sapiens)		4 / 5ALA A  92
GLN A  52
ILE A  27
ARG A  20
None
1.22A22.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Z0A_A_GLYA73_0
(NONSTRUCTURAL
PROTEIN 1)		5hhx CAT-2000 FAB LIGHT
CHAIN
(Homo
sapiens)		4 / 5GLN L  53
ALA L  50
GLN L  34
ILE L  48
None
1.29A14.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Z0A_A_GLYA73_0
(NONSTRUCTURAL
PROTEIN 1)		5jjw SQUAMOUS CELL
CARCINOMA ANTIGEN
RECOGNIZED BY
T-CELLS 3
(Homo
sapiens)		4 / 5ALA A 315
GLN A 314
ILE A 317
ARG A 349
None
EDO  A 601 ( 4.6A)
None
EDO  A 601 (-4.2A)
1.32A14.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Z0A_A_GLYA73_0
(NONSTRUCTURAL
PROTEIN 1)		5veu CYTOCHROME P450 3A5
(Homo
sapiens)		4 / 5GLN A 298
ALA A 117
ILE A 118
ARG A 439
None
None
HEM  A 601 (-4.1A)
HEM  A 601 (-3.9A)
1.31A10.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Z0A_A_GLYA73_0
(NONSTRUCTURAL
PROTEIN 1)		8fab IGG1-LAMBDA HIL FAB
(LIGHT CHAIN)
(Homo
sapiens)		4 / 5GLN A  30
ALA A  89
GLN A  88
ILE A  96
None
1.08A13.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Z0A_C_GLYC73_0
(NONSTRUCTURAL
PROTEIN 1)		1ux6 THROMBOSPONDIN-1
(Homo
sapiens)		4 / 4ASP A 843
ASP A 832
SER A1013
ARG A1016
 CA  A2010 (-3.1A)
CA  A2012 ( 2.8A)
None
None
1.45A13.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Z0A_C_GLYC73_0
(NONSTRUCTURAL
PROTEIN 1)		2rhp THROMBOSPONDIN-2
(Homo
sapiens)		4 / 4ASP A 863
ASP A 852
SER A1033
ARG A1036
 CA  A  10 (-3.1A)
CA  A  12 ( 2.6A)
None
NAG  A   4 ( 3.8A)
1.49A8.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZT7_A_GLYA1300_0
(GLYCYL-TRNA
SYNTHETASE)		3egi TRIMETHYLGUANOSINE
SYNTHASE HOMOLOG
(Homo
sapiens)		4 / 7ARG A 848
GLU A 825
GLU A 827
SER A 656
None
1.10A15.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZT7_A_GLYA1300_0
(GLYCYL-TRNA
SYNTHETASE)		4e54 DNA DAMAGE-BINDING
PROTEIN 2
(Homo
sapiens)		4 / 7GLU B  29
ARG B  25
GLU B  31
SER B  82
None
1.21A20.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZT7_A_GLYA1300_0
(GLYCYL-TRNA
SYNTHETASE)		4nhy 2-OXOGLUTARATE AND
IRON-DEPENDENT
OXYGENASE
DOMAIN-CONTAINING
PROTEIN 1
(Homo
sapiens)		4 / 7GLU A 457
ARG A 505
TYR A 541
ARG A 255
None
1.20A21.14
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2ZT7_A_GLYA1300_0
(GLYCYL-TRNA
SYNTHETASE)		4qei GLYCINE--TRNA LIGASE
(Homo
sapiens)		6 / 7GLU A 245
ARG A 277
GLU A 296
ARG A 410
GLU A 522
SER A 524
None
AMP  A 701 (-2.9A)
None
None
None
AMP  A 701 (-3.2A)
0.54A99.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZT7_A_GLYA1300_0
(GLYCYL-TRNA
SYNTHETASE)		5dot CARBAMOYL-PHOSPHATE
SYNTHASE [AMMONIA],
MITOCHONDRIAL
(Homo
sapiens)		4 / 7ARG A 718
GLU A 696
GLU A 635
SER A 723
None
1.06A19.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZT7_A_GLYA1300_0
(GLYCYL-TRNA
SYNTHETASE)		5gu6 ENDOPLASMIC
RETICULUM RESIDENT
PROTEIN 44
(Homo
sapiens)		4 / 7GLU A 229
ARG A 372
ARG A  95
GLU A  93
None
1.24A21.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZT7_A_GLYA1300_0
(GLYCYL-TRNA
SYNTHETASE)		6gru ADP-SUGAR
PYROPHOSPHATASE
(Homo
sapiens)		4 / 7GLU A 166
ARG A  84
GLU A 116
GLU A 112
 MG  A 302 ( 2.5A)
MG  A 301 ( 4.5A)
MG  A 301 ( 2.5A)
MG  A 302 (-2.5A)
1.28Aundetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3PGY_A_GLYA510_0
(SERINE
HYDROXYMETHYLTRANSFE
RASE)		1b4j ANTIBODY
(Homo
sapiens)		4 / 6ILE L   2
GLU L  27
ALA L  25
ASN L  28
None
0.92A20.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3PGY_A_GLYA510_0
(SERINE
HYDROXYMETHYLTRANSFE
RASE)		1bbj IGG4-KAPPA B72.3 FAB
(LIGHT CHAIN)
(Homo
sapiens;
Mus
musculus)		4 / 6ILE L   2
GLU L  27
ALA L  25
ASN L  28
None
1.10A19.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3PGY_A_GLYA510_0
(SERINE
HYDROXYMETHYLTRANSFE
RASE)		1k6m 6-PHOSPHOFRUCTO-2-KI
NASE/FRUCTOSE-2,6-BI
PHOSPHATASE
2-PHOSPHATASE
(Homo
sapiens)		4 / 6GLU A 365
ILE A 328
GLU A 327
ASN A 326
None
None
PO4  A 501 (-3.9A)
None
0.98A22.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3PGY_A_GLYA510_0
(SERINE
HYDROXYMETHYLTRANSFE
RASE)		1pl0 BIFUNCTIONAL PURINE
BIOSYNTHESIS PROTEIN
PURH
(Homo
sapiens)		4 / 6ILE A 228
PHE A 318
ALA A 243
ASN A 239
None
1.01A22.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3PGY_A_GLYA510_0
(SERINE
HYDROXYMETHYLTRANSFE
RASE)		2diw PUTATIVE RNA-BINDING
PROTEIN 16
(Homo
sapiens)		4 / 6ILE A  38
GLU A  19
ALA A  42
ASN A  17
None
1.06A14.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3PGY_A_GLYA510_0
(SERINE
HYDROXYMETHYLTRANSFE
RASE)		2vxo GMP SYNTHASE
[GLUTAMINE-HYDROLYZI
NG]
(Homo
sapiens)		4 / 6ILE A 339
PHE A 274
ALA A 444
ASN A 272
None
0.99A22.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3PGY_A_GLYA510_0
(SERINE
HYDROXYMETHYLTRANSFE
RASE)		4a5w COMPLEMENT C5
(Homo
sapiens)		4 / 6ILE A1432
GLU A1481
PHE A1477
ALA A1434
None
0.99A14.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3PGY_A_GLYA510_0
(SERINE
HYDROXYMETHYLTRANSFE
RASE)		4b8w GDP-L-FUCOSE
SYNTHASE
(Homo
sapiens)		4 / 6ILE A 169
GLU A 128
ALA A 284
ASN A 286
None
1.12A22.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3PGY_A_GLYA510_0
(SERINE
HYDROXYMETHYLTRANSFE
RASE)		4d4l 6-PHOSPHOFRUCTO-2-KI
NASE/FRUCTOSE-2,6-BI
SPHOSPHATASE 3
(Homo
sapiens)		4 / 6GLU A 360
ILE A 323
GLU A 322
ASN A 321
None
None
F6P  A1448 (-3.7A)
None
0.99A20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3PGY_A_GLYA510_0
(SERINE
HYDROXYMETHYLTRANSFE
RASE)		5a3f DYNAMIN 3
(Homo
sapiens)		4 / 6ILE A 581
PHE A 598
ALA A 583
ASN A 526
None
1.09A20.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3PGY_A_GLYA510_0
(SERINE
HYDROXYMETHYLTRANSFE
RASE)		5ajz 6-PHOSPHOFRUCTO-2-KI
NASE/FRUCTOSE-2,6-BI
SPHOSPHATASE 3
(Homo
sapiens)		4 / 6GLU A 360
ILE A 323
GLU A 322
ASN A 321
None
None
F6P  A1447 (-3.5A)
None
0.99A21.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3PGY_A_GLYA510_0
(SERINE
HYDROXYMETHYLTRANSFE
RASE)		5hho JM22 TCR ALPHA CHAIN
(Homo
sapiens)		4 / 6ILE D  14
GLU D  18
ALA D  80
ASN D  19
None
1.08A20.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3PGY_A_GLYA510_0
(SERINE
HYDROXYMETHYLTRANSFE
RASE)		5htk 6-PHOSPHOFRUCTO-2-KI
NASE/FRUCTOSE-2,6-BI
SPHOSPHATASE 2
(Homo
sapiens)		4 / 6GLU A 364
ILE A 327
GLU A 326
ASN A 325
None
F6P  A 604 ( 4.4A)
F6P  A 604 (-3.1A)
None
1.01A22.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3PGY_A_GLYA510_0
(SERINE
HYDROXYMETHYLTRANSFE
RASE)		5j68 ASTROTACTIN-2
(Homo
sapiens)		4 / 6GLU A1148
GLU A1149
ALA A1147
ASN A1145
None
1.14A20.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3PGY_B_GLYB509_0
(SERINE
HYDROXYMETHYLTRANSFE
RASE)		2he3 GLUTATHIONE
PEROXIDASE 2
(Homo
sapiens)		4 / 4PHE A  47
THR A  43
LEU A  86
TYR A  95
None
1.31A17.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3PGY_B_GLYB509_0
(SERINE
HYDROXYMETHYLTRANSFE
RASE)		3swv BREFELDIN
A-INHIBITED GUANINE
NUCLEOTIDE-EXCHANGE
PROTEIN 2
(Homo
sapiens)		4 / 4PHE A 763
THR A 761
LEU A 810
TYR A 814
None
1.44A19.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3PGY_B_GLYB511_0
(SERINE
HYDROXYMETHYLTRANSFE
RASE)		1u71 DIHYDROFOLATE
REDUCTASE
(Homo
sapiens)		4 / 5SER A  90
GLU A 104
LEU A  99
GLN A 102
None
1.45A19.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3PGY_B_GLYB511_0
(SERINE
HYDROXYMETHYLTRANSFE
RASE)		2c3n GLUTATHIONE
S-TRANSFERASE THETA
1
(Homo
sapiens)		4 / 5SER A 109
GLU A 173
LEU A 106
GLN A 102
None
1.30A20.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3PGY_B_GLYB511_0
(SERINE
HYDROXYMETHYLTRANSFE
RASE)		2o36 THIMET
OLIGOPEPTIDASE
(Homo
sapiens)		5 / 5SER A 461
GLU A 467
LEU A 463
GLN A 464
LYS A 357
None
1.01A20.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3PGY_B_GLYB511_0
(SERINE
HYDROXYMETHYLTRANSFE
RASE)		4b3g DNA-BINDING PROTEIN
SMUBP-2
(Homo
sapiens)		4 / 5GLU A 226
LEU A 229
GLN A 230
LYS A 233
None
0.45A21.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3PGY_B_GLYB511_0
(SERINE
HYDROXYMETHYLTRANSFE
RASE)		4pxj C-JUN-AMINO-TERMINAL
KINASE-INTERACTING
PROTEIN 3
(Homo
sapiens)		4 / 5GLU A 454
LEU A 451
GLN A 450
LYS A 447
None
1.15A11.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RGL_A_GLYA301_0
(GLYCYL-TRNA
SYNTHETASE ALPHA
SUBUNIT)		1pk6 COMPLEMENT C1Q
SUBCOMPONENT, A
CHAIN PRECURSOR
COMPLEMENT C1Q
SUBCOMPONENT, B
CHAIN PRECURSOR
(Homo
sapiens;
Homo
sapiens)		4 / 8GLY B 184
THR B 144
GLN A 142
THR B 182
None
0.91A18.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RGL_A_GLYA301_0
(GLYCYL-TRNA
SYNTHETASE ALPHA
SUBUNIT)		1rx0 ACYL-COA
DEHYDROGENASE FAMILY
MEMBER 8,
MITOCHONDRIAL
(Homo
sapiens)		4 / 8ALA A  34
GLY A  93
THR A  92
THR A  98
None
None
EDO  A2001 ( 4.6A)
None
0.81A20.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RGL_A_GLYA301_0
(GLYCYL-TRNA
SYNTHETASE ALPHA
SUBUNIT)		1s1d APYRASE
(Homo
sapiens)		4 / 8ALA A  31
GLY A  32
THR A  29
THR A  65
None
0.92A21.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RGL_A_GLYA301_0
(GLYCYL-TRNA
SYNTHETASE ALPHA
SUBUNIT)		1s35 SPECTRIN BETA CHAIN,
ERYTHROCYTE
(Homo
sapiens)		4 / 8ALA A1152
GLY A1149
THR A1148
GLN A1081
None
0.94A22.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RGL_A_GLYA301_0
(GLYCYL-TRNA
SYNTHETASE ALPHA
SUBUNIT)		1zoq INTERFERON
REGULATORY FACTOR 3
(Homo
sapiens)		4 / 8GLN A 214
GLN A 217
GLU A 205
THR A 207
None
0.93A20.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RGL_A_GLYA301_0
(GLYCYL-TRNA
SYNTHETASE ALPHA
SUBUNIT)		2es3 THROMBOSPONDIN-1
(Homo
sapiens)		4 / 8ALA A 107
GLY A 108
THR A 109
GLU A 126
None
0.93A21.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RGL_A_GLYA301_0
(GLYCYL-TRNA
SYNTHETASE ALPHA
SUBUNIT)		2hz0 PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1
(Homo
sapiens)		4 / 8ALA A 399
GLY A 398
ARG A 386
GLN A 252
None
0.74A18.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RGL_A_GLYA301_0
(GLYCYL-TRNA
SYNTHETASE ALPHA
SUBUNIT)		2p28 INTEGRIN BETA-2
INTEGRIN BETA-2
(Homo
sapiens;
Homo
sapiens)		4 / 8GLN B 418
GLN A  66
GLU A  64
THR A  82
None
0.82A18.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RGL_A_GLYA301_0
(GLYCYL-TRNA
SYNTHETASE ALPHA
SUBUNIT)		3a77 INTERFERON
REGULATORY FACTOR 3
(Homo
sapiens)		4 / 8GLN A 214
GLN A 217
GLU A 205
THR A 207
None
0.82A17.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RGL_A_GLYA301_0
(GLYCYL-TRNA
SYNTHETASE ALPHA
SUBUNIT)		3drx BTB/POZ
DOMAIN-CONTAINING
PROTEIN KCTD5
(Homo
sapiens)		4 / 8ALA A  89
GLY A  88
THR A  87
GLU A  86
None
0.65A20.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RGL_A_GLYA301_0
(GLYCYL-TRNA
SYNTHETASE ALPHA
SUBUNIT)		3drz BTB/POZ
DOMAIN-CONTAINING
PROTEIN KCTD5
(Homo
sapiens)		4 / 8ALA A  89
GLY A  88
THR A  87
GLU A  86
None
0.81A17.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RGL_A_GLYA301_0
(GLYCYL-TRNA
SYNTHETASE ALPHA
SUBUNIT)		3fhc ATP-DEPENDENT RNA
HELICASE DDX19B
(Homo
sapiens)		4 / 8ALA B 146
GLY B 143
THR B 142
GLN B 119
None
0.86A22.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RGL_A_GLYA301_0
(GLYCYL-TRNA
SYNTHETASE ALPHA
SUBUNIT)		3nr1 HD DOMAIN-CONTAINING
PROTEIN 3
(Homo
sapiens)		4 / 8ALA A  80
GLY A  79
ARG A  84
GLN A  81
None
0.90A22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RGL_A_GLYA301_0
(GLYCYL-TRNA
SYNTHETASE ALPHA
SUBUNIT)		3nvn PLEXIN-C1
(Homo
sapiens)		4 / 8ALA B 133
GLY B 132
THR B 151
ARG B  81
None
0.91A21.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RGL_A_GLYA301_0
(GLYCYL-TRNA
SYNTHETASE ALPHA
SUBUNIT)		3ol2 PLEXIN-B1
(Homo
sapiens)		4 / 8GLY B 125
GLN B  57
GLU B  65
THR B  46
None
0.91A19.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RGL_A_GLYA301_0
(GLYCYL-TRNA
SYNTHETASE ALPHA
SUBUNIT)		3zyx AMINE OXIDASE
[FLAVIN-CONTAINING]
B
(Homo
sapiens)		5 / 8ALA A 442
GLY A 425
THR A 426
ARG A 445
GLU A 427
None
FAD  A 600 (-3.3A)
FAD  A 600 (-3.4A)
None
None
1.38A18.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RGL_A_GLYA301_0
(GLYCYL-TRNA
SYNTHETASE ALPHA
SUBUNIT)		4crh SH3KBP1-BINDING
PROTEIN 1
(Homo
sapiens)		4 / 8ALA A  62
GLY A  61
THR A  60
GLU A  59
None
0.72A23.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RGL_A_GLYA301_0
(GLYCYL-TRNA
SYNTHETASE ALPHA
SUBUNIT)		4h27 L-SERINE
DEHYDRATASE/L-THREON
INE DEAMINASE
(Homo
sapiens)		4 / 8ALA A  23
GLY A  24
THR A  25
GLN A 283
None
0.70A25.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RGL_A_GLYA301_0
(GLYCYL-TRNA
SYNTHETASE ALPHA
SUBUNIT)		5a6r BTB/POZ
DOMAIN-CONTAINING
PROTEIN KCTD17
(Homo
sapiens)		4 / 8ALA A  75
GLY A  74
THR A  73
GLU A  72
None
0.75A21.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RGL_A_GLYA301_0
(GLYCYL-TRNA
SYNTHETASE ALPHA
SUBUNIT)		5b4w PLEXIN-B1
(Homo
sapiens)		4 / 8GLY A 125
GLN A  57
GLU A  65
THR A  46
None
0.93A18.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RGL_A_GLYA301_0
(GLYCYL-TRNA
SYNTHETASE ALPHA
SUBUNIT)		5hkj COMPLEMENT C1Q
SUBCOMPONENT SUBUNIT
A,COMPLEMENT C1Q
SUBCOMPONENT SUBUNIT
C,COMPLEMENT C1Q
SUBCOMPONENT SUBUNIT
B
(Homo
sapiens)		4 / 8GLY A 368
THR A 328
GLN A  55
THR A 366
None
0.94A20.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KR3_A_GLYA701_0
(GLYCINE--TRNA LIGASE)		1cjy PROTEIN (CYTOSOLIC
PHOSPHOLIPASE A2)
(Homo
sapiens)		4 / 6GLU A 348
GLU A 353
ARG A 566
GLU A 154
None
1.45A22.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KR3_A_GLYA701_0
(GLYCINE--TRNA LIGASE)		1s9i DUAL SPECIFICITY
MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE 2
(Homo
sapiens)		4 / 6GLU A 167
GLU A 168
ARG A 371
GLU A 375
None
1.39A20.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KR3_A_GLYA701_0
(GLYCINE--TRNA LIGASE)		3egi TRIMETHYLGUANOSINE
SYNTHASE HOMOLOG
(Homo
sapiens)		4 / 6ARG A 848
GLU A 825
GLU A 827
SER A 656
None
1.07A16.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KR3_A_GLYA701_0
(GLYCINE--TRNA LIGASE)		3fjo NADPH-CYTOCHROME
P450 REDUCTASE
(Saccharomyces
cerevisiae;
Homo
sapiens)		4 / 6GLU A 295
ARG A 293
GLU A 526
SER A 441
None
1.17A19.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KR3_A_GLYA701_0
(GLYCINE--TRNA LIGASE)		3j7y BL21
ML43
(Homo
sapiens;
Homo
sapiens)		4 / 6ARG S 194
GLU S 162
ARG b   9
SER b 108
None
1.32A15.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KR3_A_GLYA701_0
(GLYCINE--TRNA LIGASE)		3m7p FN1 PROTEIN
(Homo
sapiens)		4 / 6GLU A 377
GLU A 537
ARG A 592
GLU A 596
 ZN  A 955 ( 4.3A)
ZN  A 955 (-2.6A)
None
ZN  A 955 ( 3.9A)
1.36A17.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KR3_A_GLYA701_0
(GLYCINE--TRNA LIGASE)		4dpg LYSINE--TRNA LIGASE
(Homo
sapiens)		4 / 6ARG A 323
GLU A 494
ARG A 485
GLU A 487
APC  A 602 (-3.1A)
MG  A 603 ( 3.4A)
None
MG  A 603 (-3.4A)
1.32A22.89
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4KR3_A_GLYA701_0
(GLYCINE--TRNA LIGASE)		4qei GLYCINE--TRNA LIGASE
(Homo
sapiens)		6 / 6GLU A 245
ARG A 277
GLU A 296
ARG A 410
GLU A 522
SER A 524
None
AMP  A 701 (-2.9A)
None
None
None
AMP  A 701 (-3.2A)
0.71A99.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KR3_A_GLYA701_0
(GLYCINE--TRNA LIGASE)		5dot CARBAMOYL-PHOSPHATE
SYNTHASE [AMMONIA],
MITOCHONDRIAL
(Homo
sapiens)		4 / 6ARG A 718
GLU A 696
GLU A 635
SER A 723
None
1.41A19.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KR3_A_GLYA701_0
(GLYCINE--TRNA LIGASE)		5hmp UNCONVENTIONAL
MYOSIN-VC
(Homo
sapiens)		4 / 6GLU A 448
ARG A 217
GLU A 243
SER A 245
None
1.08A21.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KR3_A_GLYA701_0
(GLYCINE--TRNA LIGASE)		6bq1 PHOSPHATIDYLINOSITOL
4-KINASE III ALPHA
(PI4KA)
(Homo
sapiens)		4 / 6GLU A1397
ARG A1401
ARG A2022
GLU A2018
None
1.43Aundetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KR3_A_GLYA701_0
(GLYCINE--TRNA LIGASE)		6fbk SERINE/THREONINE-PRO
TEIN KINASE WNK2
SERINE/THREONINE-PRO
TEIN KINASE WNK1
(Homo
sapiens;
Homo
sapiens)		4 / 6GLU A 505
GLU A 509
ARG P1256
GLU A 513
None
1.21Aundetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YSH_B_GLYB401_0
(GLYCINE OXIDASE)		2cxy BAF250B SUBUNIT
(Homo
sapiens)		4 / 6LYS A  55
GLY A  59
ALA A  61
ARG A 105
None
1.16A16.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YSH_B_GLYB401_0
(GLYCINE OXIDASE)		2oj4 REGULATOR OF
G-PROTEIN SIGNALING
3
(Homo
sapiens)		4 / 6PHE A 117
GLY A  21
TYR A 123
ALA A   5
None
1.28A16.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YSH_B_GLYB401_0
(GLYCINE OXIDASE)		2wno TUMOR NECROSIS
FACTOR-INDUCIBLE
GENE 6 PROTEIN
(Homo
sapiens)		4 / 6PHE A 229
GLY A 239
TYR A 155
ALA A 237
None
1.27A15.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YSH_B_GLYB401_0
(GLYCINE OXIDASE)		5igq E3 UBIQUITIN-PROTEIN
LIGASE RFWD2
(Homo
sapiens)		4 / 6PHE A 595
LYS A 629
GLY A 628
TYR A 582
None
1.21A20.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YSH_B_GLYB402_0
(GLYCINE OXIDASE)		1k2p TYROSINE-PROTEIN
KINASE BTK
(Homo
sapiens)		4 / 5MET A 449
GLU A 445
ARG A 520
ARG A 544
None
1.31A21.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YSH_B_GLYB402_0
(GLYCINE OXIDASE)		6c01 ECTONUCLEOTIDE
PYROPHOSPHATASE/PHOS
PHODIESTERASE FAMILY
MEMBER 3
(Homo
sapiens)		4 / 5MET A 200
GLU A 513
TYR A 217
ARG A 838
None
None
NAG  A 912 ( 3.9A)
None
1.19Aundetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YSH_B_GLYB402_0
(GLYCINE OXIDASE)		6db5 HUMAN MONOCLONAL
ANTI-HIV-1 GP120 V3
ANTIBODY TA6 FAB
HEAVY CHAIN
(Homo
sapiens)		4 / 5MET H  48
GLU H  46
TYR H  90
ARG H  66
None
1.49Aundetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZXI_A_GLYA1402_0
(TYROCIDINE
SYNTHETASE 3)		1dmw PHENYLALANINE
HYDROXYLASE
(Homo
sapiens)		4 / 7ASP A 282
ILE A 269
GLY A 272
THR A 278
None
1.09A13.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZXI_A_GLYA1402_0
(TYROCIDINE
SYNTHETASE 3)		1zef ALKALINE PHOSPHATASE
(Homo
sapiens)		4 / 7PHE A  39
ILE A 338
GLY A 342
THR A 292
None
1.13A16.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZXI_A_GLYA1402_0
(TYROCIDINE
SYNTHETASE 3)		2hxs RAS-RELATED PROTEIN
RAB-28
(Homo
sapiens)		4 / 7ASP A  68
ILE A  69
GLY A  19
THR A  26
 MG  A 402 ( 4.0A)
None
None
MG  A 402 ( 3.0A)
1.01A8.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZXI_A_GLYA1402_0
(TYROCIDINE
SYNTHETASE 3)		2w3c GENERAL VESICULAR
TRANSPORT FACTOR
P115
(Homo
sapiens)		4 / 7PHE A 577
ILE A 568
GLY A 546
THR A 625
None
1.13A19.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZXI_A_GLYA1402_0
(TYROCIDINE
SYNTHETASE 3)		4byf UNCONVENTIONAL
MYOSIN-IC
(Homo
sapiens)		4 / 7ASP A 386
ILE A 387
GLY A 389
THR A 112
 MG  A1000 ( 4.0A)
None
AOV  A1001 (-3.1A)
MG  A1000 ( 2.6A)
0.92A20.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZXI_A_GLYA1402_0
(TYROCIDINE
SYNTHETASE 3)		4r7a HISTONE-BINDING
PROTEIN RBBP4
(Homo
sapiens)		4 / 7ASP B 199
GLY B 180
THR B 201
LYS B 143
None
1.12A16.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZXI_A_GLYA1402_0
(TYROCIDINE
SYNTHETASE 3)		5oed RAS-RELATED PROTEIN
RAB-32
(Homo
sapiens)		4 / 7ASP B  81
ILE B  82
GLY B  32
THR B  39
 MG  A 901 ( 3.7A)
None
None
MG  A 901 ( 3.2A)
0.96Aundetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HHJ_A_GLYA403_0
(RETRON-TYPE REVERSE
TRANSCRIPTASE)		2yrz INTEGRIN BETA-4
(Homo
sapiens)		4 / 4LEU A  81
LEU A  56
GLY A  60
GLU A  61
None
1.23A17.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HHJ_A_GLYA403_0
(RETRON-TYPE REVERSE
TRANSCRIPTASE)		3kyd SUMO-ACTIVATING
ENZYME SUBUNIT 1
(Homo
sapiens)		4 / 4LEU A  81
LEU A  44
GLY A  48
GLU A  50
None
1.17A21.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HHJ_A_GLYA403_0
(RETRON-TYPE REVERSE
TRANSCRIPTASE)		4fao ACTIVIN RECEPTOR
TYPE-2B
(Homo
sapiens)		4 / 4LEU E  61
LEU E  39
GLY E  33
GLU E  34
None
1.22A15.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HHJ_A_GLYA403_0
(RETRON-TYPE REVERSE
TRANSCRIPTASE)		4kkd MANNAN-BINDING
LECTIN SERINE
PROTEASE 1
(Homo
sapiens)		4 / 4LEU A 466
LEU A 617
GLY A 592
GLU A 666
None
1.24A18.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HHJ_A_GLYA403_0
(RETRON-TYPE REVERSE
TRANSCRIPTASE)		4p22 UBIQUITIN-LIKE
MODIFIER-ACTIVATING
ENZYME 1
(Homo
sapiens)		4 / 4LEU A 135
LEU A  80
GLY A  84
GLU A  86
None
1.13A22.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HHJ_A_GLYA403_0
(RETRON-TYPE REVERSE
TRANSCRIPTASE)		5cgy HEAVY CHAIN OF FAB
(Homo
sapiens)		4 / 4LEU H 152
LEU H 203
GLY H 204
GLU H 226
None
1.26A17.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HHJ_A_GLYA403_0
(RETRON-TYPE REVERSE
TRANSCRIPTASE)		5dse TETRATRICOPEPTIDE
REPEAT PROTEIN 7B
(Homo
sapiens)		4 / 4LEU A 787
LEU A 808
GLY A 805
GLU A 806
None
1.09A16.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HHJ_A_GLYA403_0
(RETRON-TYPE REVERSE
TRANSCRIPTASE)		5j1g PLECTIN
(Homo
sapiens)		4 / 4LEU A1101
LEU A1063
GLY A1062
GLU A1061
None
1.25A20.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HHJ_A_GLYA403_0
(RETRON-TYPE REVERSE
TRANSCRIPTASE)		5j1i PLECTIN
(Homo
sapiens)		4 / 4LEU A1101
LEU A1063
GLY A1062
GLU A1061
None
1.25A18.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HHJ_A_GLYA403_0
(RETRON-TYPE REVERSE
TRANSCRIPTASE)		5tet ATP-CITRATE SYNTHASE
(Homo
sapiens)		4 / 4LEU B 702
LEU B 736
GLY B 730
GLU B 733
None
0.98A21.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HHJ_B_GLYB404_0
(RETRON-TYPE REVERSE
TRANSCRIPTASE)		3up1 INTERLEUKIN-7
RECEPTOR SUBUNIT
ALPHA
(Homo
sapiens)		4 / 4GLN A 151
ALA A 179
GLN A 176
THR A 208
None
1.44A19.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HHJ_B_GLYB404_0
(RETRON-TYPE REVERSE
TRANSCRIPTASE)		4q6r SPHINGOSINE-1-PHOSPH
ATE LYASE 1
(Homo
sapiens)		4 / 4GLN A 478
ALA A 529
GLN A 530
THR A 532
None
1.21A21.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HHJ_B_GLYB404_0
(RETRON-TYPE REVERSE
TRANSCRIPTASE)		5do7 ATP-BINDING CASSETTE
SUB-FAMILY G MEMBER
5
(Homo
sapiens)		4 / 4GLN A 206
ALA A 205
GLN A 209
THR A 151
None
1.33A18.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AF6_A_GLYA507_0
(L-PROLYL-[PEPTIDYL-C
ARRIER PROTEIN]
DEHYDROGENASE)		1k27 5'-DEOXY-5'-METHYLTH
IOADENOSINE
PHOSPHORYLASE
(Homo
sapiens)		3 / 3TYR A  74
HIS A  61
MET A  68
None
PO4  A 301 ( 3.8A)
None
1.17A20.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AF6_A_GLYA507_0
(L-PROLYL-[PEPTIDYL-C
ARRIER PROTEIN]
DEHYDROGENASE)		1kfu M-CALPAIN LARGE
SUBUNIT
(Homo
sapiens)		3 / 3TYR L 146
HIS L 415
MET L 422
None
1.16A19.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AF6_A_GLYA507_0
(L-PROLYL-[PEPTIDYL-C
ARRIER PROTEIN]
DEHYDROGENASE)		1m9i ANNEXIN VI
(Homo
sapiens)		3 / 3TYR A 481
HIS A 438
MET A 434
None
1.26A21.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AF6_A_GLYA507_0
(L-PROLYL-[PEPTIDYL-C
ARRIER PROTEIN]
DEHYDROGENASE)		1ya0 SMG-7 TRANSCRIPT
VARIANT 2
(Homo
sapiens)		3 / 3TYR A  40
HIS A  63
MET A  19
None
1.10A22.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AF6_A_GLYA507_0
(L-PROLYL-[PEPTIDYL-C
ARRIER PROTEIN]
DEHYDROGENASE)		1z6y ADP-RIBOSYLATION
FACTOR-LIKE PROTEIN
5
(Homo
sapiens)		3 / 3TYR A  80
HIS A 112
MET A 109
None
1.08A18.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AF6_A_GLYA507_0
(L-PROLYL-[PEPTIDYL-C
ARRIER PROTEIN]
DEHYDROGENASE)		2yt4 PROTEIN DGCR8
(Homo
sapiens)		3 / 3TYR A 530
HIS A 517
MET A 520
None
1.15A22.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AF6_A_GLYA507_0
(L-PROLYL-[PEPTIDYL-C
ARRIER PROTEIN]
DEHYDROGENASE)		3kuq RHO
GTPASE-ACTIVATING
PROTEIN 7
(Homo
sapiens)		3 / 3TYR A1174
HIS A1275
MET A1276
None
1.21A19.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AF6_A_GLYA507_0
(L-PROLYL-[PEPTIDYL-C
ARRIER PROTEIN]
DEHYDROGENASE)		3v4o MUCOSA-ASSOCIATED
LYMPHOID TISSUE
LYMPHOMA
TRANSLOCATION
PROTEIN 1
(Homo
sapiens)		3 / 3TYR A 434
HIS A 415
MET A 463
None
1.07A21.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AF6_A_GLYA507_0
(L-PROLYL-[PEPTIDYL-C
ARRIER PROTEIN]
DEHYDROGENASE)		5cek TRIBBLES HOMOLOG 1
(Homo
sapiens)		3 / 3TYR A 248
HIS A 168
MET A 167
None
0.99A21.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AF6_A_GLYA507_0
(L-PROLYL-[PEPTIDYL-C
ARRIER PROTEIN]
DEHYDROGENASE)		5ums FACT COMPLEX SUBUNIT
SSRP1
(Homo
sapiens)		3 / 3TYR A 353
HIS A 247
MET A 253
None
1.18Aundetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AF6_A_GLYA507_0
(L-PROLYL-[PEPTIDYL-C
ARRIER PROTEIN]
DEHYDROGENASE)		5zya SPLICING FACTOR 3B
SUBUNIT 1
(Homo
sapiens)		3 / 3TYR C1136
HIS C1184
MET C1178
None
1.22Aundetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AF6_A_GLYA507_0
(L-PROLYL-[PEPTIDYL-C
ARRIER PROTEIN]
DEHYDROGENASE)		6c9m N-ALPHA-ACETYLTRANSF
ERASE 10
(Homo
sapiens)		3 / 3TYR B 138
HIS B 110
MET B 147
None
1.26Aundetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DWD_A_GLYA715_0
(DEOXYNUCLEOSIDE
TRIPHOSPHATE
TRIPHOSPHOHYDROLASE
SAMHD1)		1h5p NUCLEAR AUTOANTIGEN
SP100-B
(Homo
sapiens)		4 / 6GLY A 610
ASP A 648
SER A 658
ARG A 660
None
1.21A12.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DWD_A_GLYA715_0
(DEOXYNUCLEOSIDE
TRIPHOSPHATE
TRIPHOSPHOHYDROLASE
SAMHD1)		1q33 ADP-RIBOSE
PYROPHOSPHATASE
(Homo
sapiens)		4 / 6GLY A 152
ASN A 149
ASP A 276
ARG A  66
None
0.96A19.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DWD_A_GLYA715_0
(DEOXYNUCLEOSIDE
TRIPHOSPHATE
TRIPHOSPHOHYDROLASE
SAMHD1)		1x9n DNA LIGASE I
(Homo
sapiens)		4 / 6GLY A 769
ASP A 378
ARG A 449
ARG A 444
None
1.22A21.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DWD_A_GLYA715_0
(DEOXYNUCLEOSIDE
TRIPHOSPHATE
TRIPHOSPHOHYDROLASE
SAMHD1)		2ffu POLYPEPTIDE
N-ACETYLGALACTOSAMIN
YLTRANSFERASE 2
(Homo
sapiens)		4 / 6GLY A  88
ASP A 110
SER A 150
ARG A 149
None
1.12A23.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DWD_A_GLYA715_0
(DEOXYNUCLEOSIDE
TRIPHOSPHATE
TRIPHOSPHOHYDROLASE
SAMHD1)		2vxo GMP SYNTHASE
[GLUTAMINE-HYDROLYZI
NG]
(Homo
sapiens)		4 / 6GLY A 273
ASN A 272
ASP A 271
ARG A 589
None
0.75A23.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DWD_A_GLYA715_0
(DEOXYNUCLEOSIDE
TRIPHOSPHATE
TRIPHOSPHOHYDROLASE
SAMHD1)		2zb4 PROSTAGLANDIN
REDUCTASE 2
(Homo
sapiens)		4 / 6GLY A 234
ASN A 235
ASP A 238
SER A 270
None
SO4  A2005 (-3.9A)
None
None
0.87A18.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DWD_A_GLYA715_0
(DEOXYNUCLEOSIDE
TRIPHOSPHATE
TRIPHOSPHOHYDROLASE
SAMHD1)		3ikm DNA POLYMERASE
SUBUNIT GAMMA-1
(Homo
sapiens)		4 / 6GLY A 928
ASP A 930
SER A 933
ARG A 943
None
1.19A17.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DWD_A_GLYA715_0
(DEOXYNUCLEOSIDE
TRIPHOSPHATE
TRIPHOSPHOHYDROLASE
SAMHD1)		3rl7 DISKS LARGE HOMOLOG
1
(Homo
sapiens)		4 / 6GLY B 241
ASN B 244
ASP B 243
SER B 290
None
1.10A14.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DWD_A_GLYA715_0
(DEOXYNUCLEOSIDE
TRIPHOSPHATE
TRIPHOSPHOHYDROLASE
SAMHD1)		5gje LOW-DENSITY
LIPOPROTEIN
RECEPTOR-RELATED
PROTEIN 6
(Homo
sapiens)		4 / 6GLY A  80
ASP A  79
SER A  95
ARG A 122
None
1.02A22.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DWD_A_GLYA715_0
(DEOXYNUCLEOSIDE
TRIPHOSPHATE
TRIPHOSPHOHYDROLASE
SAMHD1)		5gje LOW-DENSITY
LIPOPROTEIN
RECEPTOR-RELATED
PROTEIN 6
(Homo
sapiens)		4 / 6GLY B 822
ASN B 819
SER B 817
ARG B 825
None
1.07A21.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DWD_A_GLYA715_0
(DEOXYNUCLEOSIDE
TRIPHOSPHATE
TRIPHOSPHOHYDROLASE
SAMHD1)		5iz5 CYTOSOLIC
PHOSPHOLIPASE A2
DELTA
(Homo
sapiens)		4 / 6GLY B 233
ASN B 229
SER B 225
ARG B 224
None
1.08A20.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DWD_A_GLYA715_0
(DEOXYNUCLEOSIDE
TRIPHOSPHATE
TRIPHOSPHOHYDROLASE
SAMHD1)		5ndf POLYPEPTIDE
N-ACETYLGALACTOSAMIN
YLTRANSFERASE 2
(Homo
sapiens)		4 / 6GLY A  88
ASP A 110
SER A 150
ARG A 149
None
1.18A22.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DWD_A_GLYA715_0
(DEOXYNUCLEOSIDE
TRIPHOSPHATE
TRIPHOSPHOHYDROLASE
SAMHD1)		6bsz METABOTROPIC
GLUTAMATE RECEPTOR 8
(Homo
sapiens)		4 / 6ASN A 186
SER A 193
ARG A 194
ARG A 447
None
1.15Aundetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DWD_A_GLYA715_0
(DEOXYNUCLEOSIDE
TRIPHOSPHATE
TRIPHOSPHOHYDROLASE
SAMHD1)		6ejb XYLOSYLTRANSFERASE 1
(Homo
sapiens)		4 / 6ASP A 944
SER A 947
ARG A 344
ARG A 340
None
1.06Aundetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DWD_A_GLYA717_0
(DEOXYNUCLEOSIDE
TRIPHOSPHATE
TRIPHOSPHOHYDROLASE
SAMHD1)		1b2i PROTEIN
(PLASMINOGEN)
(Homo
sapiens)		4 / 5SER A  -3
ASP A  10
ARG A  52
LYS A  47
None
1.39A10.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DWD_A_GLYA717_0
(DEOXYNUCLEOSIDE
TRIPHOSPHATE
TRIPHOSPHOHYDROLASE
SAMHD1)		1qgr PROTEIN (IMPORTIN
BETA SUBUNIT)
PROTEIN (IMPORTIN
ALPHA-2 SUBUNIT)
(Homo
sapiens;
Homo
sapiens)		4 / 5SER A 633
ASP A 676
ARG B  39
LYS B  42
None
1.19A19.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DWD_A_GLYA717_0
(DEOXYNUCLEOSIDE
TRIPHOSPHATE
TRIPHOSPHOHYDROLASE
SAMHD1)		2dw4 LYSINE-SPECIFIC
HISTONE DEMETHYLASE
1
(Homo
sapiens)		4 / 5SER A 522
ARG A 524
ASP A 525
LYS A 374
None
1.28A20.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DWD_A_GLYA717_0
(DEOXYNUCLEOSIDE
TRIPHOSPHATE
TRIPHOSPHOHYDROLASE
SAMHD1)		4hqp ALPHA7 NICOTINIC
RECEPTOR CHIMERA
(Lymnaea
stagnalis;
Homo
sapiens)		4 / 5SER A 180
ARG A 182
ASP A 193
LYS A 141
None
1.44A17.94
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
6DWD_A_GLYA717_0
(DEOXYNUCLEOSIDE
TRIPHOSPHATE
TRIPHOSPHOHYDROLASE
SAMHD1)		4zwe DEOXYNUCLEOSIDE
TRIPHOSPHATE
TRIPHOSPHOHYDROLASE
SAMHD1
(Homo
sapiens)		5 / 5SER A 192
ARG A 194
ASP A 195
ARG A 290
LYS A 294
None
0.26A99.81
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
6DWD_A_GLYA717_0
(DEOXYNUCLEOSIDE
TRIPHOSPHATE
TRIPHOSPHOHYDROLASE
SAMHD1)		5ao0 DEOXYNUCLEOSIDE
TRIPHOSPHATE
TRIPHOSPHOHYDROLASE
SAMHD1
(Homo
sapiens)		5 / 5SER A 192
ARG A 194
ASP A 195
ARG A 290
LYS A 294
None
0.41A85.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DWD_B_GLYB709_0
(DEOXYNUCLEOSIDE
TRIPHOSPHATE
TRIPHOSPHOHYDROLASE
SAMHD1)		1dxx DYSTROPHIN
(Homo
sapiens)		4 / 5GLY A  47
ASN A  76
ASP A  46
ARG A  49
None
1.31A16.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DWD_B_GLYB709_0
(DEOXYNUCLEOSIDE
TRIPHOSPHATE
TRIPHOSPHOHYDROLASE
SAMHD1)		1nug PROTEIN-GLUTAMINE
GLUTAMYLTRANSFERASE
E
(Homo
sapiens)		4 / 5GLY A 230
ASN A 229
ASP A 228
ARG A 199
 CA  A 703 ( 4.4A)
None
CA  A 703 (-2.3A)
None
1.33A21.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DWD_B_GLYB709_0
(DEOXYNUCLEOSIDE
TRIPHOSPHATE
TRIPHOSPHOHYDROLASE
SAMHD1)		1q33 ADP-RIBOSE
PYROPHOSPHATASE
(Homo
sapiens)		4 / 5GLY A 152
ASN A 149
ASP A 276
ARG A  66
None
0.95A19.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DWD_B_GLYB709_0
(DEOXYNUCLEOSIDE
TRIPHOSPHATE
TRIPHOSPHOHYDROLASE
SAMHD1)		1x9n DNA LIGASE I
(Homo
sapiens)		4 / 5GLY A 769
ASP A 378
ARG A 449
ARG A 444
None
1.24A21.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DWD_B_GLYB709_0
(DEOXYNUCLEOSIDE
TRIPHOSPHATE
TRIPHOSPHOHYDROLASE
SAMHD1)		2gdz NAD+-DEPENDENT
15-HYDROXYPROSTAGLAN
DIN DEHYDROGENASE
(Homo
sapiens)		4 / 5GLY A  42
ASN A  38
ASP A  36
ARG A  19
None
None
NAD  A 300 (-2.8A)
None
1.25A21.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DWD_B_GLYB709_0
(DEOXYNUCLEOSIDE
TRIPHOSPHATE
TRIPHOSPHOHYDROLASE
SAMHD1)		2r05 PROGRAMMED CELL
DEATH 6-INTERACTING
PROTEIN
(Homo
sapiens)		4 / 5GLY A 271
ASN A 315
ASP A 321
ARG A 322
None
1.37A22.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DWD_B_GLYB709_0
(DEOXYNUCLEOSIDE
TRIPHOSPHATE
TRIPHOSPHOHYDROLASE
SAMHD1)		2rl0 FIBRONECTIN
(Homo
sapiens)		4 / 5GLY A 231
ASN A 232
ARG A 197
ARG A 234
None
1.40A10.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DWD_B_GLYB709_0
(DEOXYNUCLEOSIDE
TRIPHOSPHATE
TRIPHOSPHOHYDROLASE
SAMHD1)		2vxo GMP SYNTHASE
[GLUTAMINE-HYDROLYZI
NG]
(Homo
sapiens)		4 / 5GLY A 273
ASN A 272
ASP A 271
ARG A 589
None
0.74A23.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DWD_B_GLYB709_0
(DEOXYNUCLEOSIDE
TRIPHOSPHATE
TRIPHOSPHOHYDROLASE
SAMHD1)		3e7g NITRIC OXIDE
SYNTHASE, INDUCIBLE
(Homo
sapiens)		4 / 5GLY A 269
ASN A 283
ASP A 280
ARG A 266
None
None
None
AT2  A 906 (-3.6A)
1.32A22.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DWD_B_GLYB709_0
(DEOXYNUCLEOSIDE
TRIPHOSPHATE
TRIPHOSPHOHYDROLASE
SAMHD1)		3fe2 PROBABLE
ATP-DEPENDENT RNA
HELICASE DDX5
(Homo
sapiens)		4 / 5GLY A 167
ASN A 238
ARG A 241
ARG A 240
None
1.32A20.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DWD_B_GLYB709_0
(DEOXYNUCLEOSIDE
TRIPHOSPHATE
TRIPHOSPHOHYDROLASE
SAMHD1)		3nxp PRETHROMBIN-1
(Homo
sapiens)		4 / 5GLY A 228
ASN A 221
ASP A 225
ARG A 633
None
1.33A22.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DWD_B_GLYB709_0
(DEOXYNUCLEOSIDE
TRIPHOSPHATE
TRIPHOSPHOHYDROLASE
SAMHD1)		4chb KELCH-LIKE PROTEIN 2
(Homo
sapiens)		4 / 5GLY A 363
ASN A 362
ARG A 345
ARG A 343
None
SO4  A1596 ( 3.9A)
None
SO4  A1596 (-3.0A)
1.29A19.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DWD_B_GLYB709_0
(DEOXYNUCLEOSIDE
TRIPHOSPHATE
TRIPHOSPHOHYDROLASE
SAMHD1)		4hga HISTONE H3.3
(Homo
sapiens)		4 / 5GLY B 132
ASP B 106
ARG B 128
ARG B 134
None
1.39A13.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DWD_B_GLYB709_0
(DEOXYNUCLEOSIDE
TRIPHOSPHATE
TRIPHOSPHOHYDROLASE
SAMHD1)		5h9m E3 UBIQUITIN-PROTEIN
LIGASE SIAH2
(Homo
sapiens)		4 / 5GLY A 269
ASN A 268
ARG A 272
ARG A 273
None
1.24A15.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DWD_B_GLYB709_0
(DEOXYNUCLEOSIDE
TRIPHOSPHATE
TRIPHOSPHOHYDROLASE
SAMHD1)		5la7 HEPARANASE
(Homo
sapiens)		4 / 5GLY A 223
ASN A 224
ASP A 267
ARG A  93
None
6S6  A 613 (-2.9A)
None
6S6  A 613 ( 4.9A)
1.30A19.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DWD_B_GLYB709_0
(DEOXYNUCLEOSIDE
TRIPHOSPHATE
TRIPHOSPHOHYDROLASE
SAMHD1)		6db7 HUMAN MONOCLONAL
ANTI-HIV-1 GP120 V3
ANTIBODY 1334 FAB
HEAVY CHAIN
HIV-1 GP120 V3
PEPTIDE FROM MN
STRAIN
(Homo
sapiens;
Human
immunodeficiency
virus
1)		4 / 5GLY H  52
ASN H  52
ASP H  53
ARG P 315
None
1.27Aundetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DWD_C_GLYC713_0
(DEOXYNUCLEOSIDE
TRIPHOSPHATE
TRIPHOSPHOHYDROLASE
SAMHD1)		1jxk ALPHA-AMYLASE,
SALIVARY
(Homo
sapiens)		3 / 3GLN A 232
TYR A 247
ASN A 250
None
1.07A22.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DWD_C_GLYC713_0
(DEOXYNUCLEOSIDE
TRIPHOSPHATE
TRIPHOSPHOHYDROLASE
SAMHD1)		1mi1 NEUROBEACHIN
(Homo
sapiens)		3 / 3GLN A2149
TYR A2210
ASN A2230
None
1.01A22.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DWD_C_GLYC713_0
(DEOXYNUCLEOSIDE
TRIPHOSPHATE
TRIPHOSPHOHYDROLASE
SAMHD1)		1yjd T-CELL-SPECIFIC
SURFACE GLYCOPROTEIN
CD28
(Homo
sapiens)		3 / 3GLN C  88
TYR C  85
ASN C  87
None
NAG  C 203 (-3.4A)
NAG  C 203 (-1.9A)
0.86A12.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DWD_C_GLYC713_0
(DEOXYNUCLEOSIDE
TRIPHOSPHATE
TRIPHOSPHOHYDROLASE
SAMHD1)		2xh1 KYNURENINE/ALPHA-AMI
NOADIPATE
AMINOTRANSFERASE,
MITOCHONDRIAL
(Homo
sapiens)		3 / 3GLN A 237
TYR A 234
ASN A 199
None
0.68A23.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DWD_C_GLYC713_0
(DEOXYNUCLEOSIDE
TRIPHOSPHATE
TRIPHOSPHOHYDROLASE
SAMHD1)		2ybx PHOSPHATIDYLINOSITOL
-5-PHOSPHATE
4-KINASE TYPE-2
ALPHA
(Homo
sapiens)		3 / 3GLN A  32
TYR A  30
ASN A  83
None
0.98A25.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DWD_C_GLYC713_0
(DEOXYNUCLEOSIDE
TRIPHOSPHATE
TRIPHOSPHOHYDROLASE
SAMHD1)		3nwn KINESIN-LIKE PROTEIN
KIF9
(Homo
sapiens)		3 / 3GLN A  80
TYR A  85
ASN A 310
None
0.97A23.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DWD_C_GLYC713_0
(DEOXYNUCLEOSIDE
TRIPHOSPHATE
TRIPHOSPHOHYDROLASE
SAMHD1)		4d10 COP9 SIGNALOSOME
COMPLEX SUBUNIT 3
(Homo
sapiens)		3 / 3GLN C 132
TYR C 161
ASN C 136
None
0.97A22.73
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
6DWD_C_GLYC713_0
(DEOXYNUCLEOSIDE
TRIPHOSPHATE
TRIPHOSPHOHYDROLASE
SAMHD1)		5ao0 DEOXYNUCLEOSIDE
TRIPHOSPHATE
TRIPHOSPHOHYDROLASE
SAMHD1
(Homo
sapiens)		3 / 3GLN A 447
TYR A 450
ASN A 452
None
0.37A85.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DWD_C_GLYC713_0
(DEOXYNUCLEOSIDE
TRIPHOSPHATE
TRIPHOSPHOHYDROLASE
SAMHD1)		5lfn CHONDROADHERIN
(Homo
sapiens)		3 / 3GLN A 153
TYR A 177
ASN A 155
None
0.80A20.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DWD_C_GLYC713_0
(DEOXYNUCLEOSIDE
TRIPHOSPHATE
TRIPHOSPHOHYDROLASE
SAMHD1)		5w4b ADENOSYLHOMOCYSTEINA
SE
(Homo
sapiens)		3 / 3GLN A 251
TYR A 221
ASN A 248
None
None
NAD  A 501 (-3.2A)
1.05A20.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DWD_C_GLYC713_0
(DEOXYNUCLEOSIDE
TRIPHOSPHATE
TRIPHOSPHOHYDROLASE
SAMHD1)		5ykh PUMILIO HOMOLOG 1
(Homo
sapiens)		3 / 3GLN A 227
TYR A 224
ASN A 223
None
0.68Aundetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DWD_D_GLYD713_0
(DEOXYNUCLEOSIDE
TRIPHOSPHATE
TRIPHOSPHOHYDROLASE
SAMHD1)		1luj CATENIN BETA-1
(Homo
sapiens)		3 / 3ARG A 515
HIS A 578
ARG A 582
None
1.01A21.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DWD_D_GLYD713_0
(DEOXYNUCLEOSIDE
TRIPHOSPHATE
TRIPHOSPHOHYDROLASE
SAMHD1)		1yyh NOTCH 1, ANKYRIN
DOMAIN
(Homo
sapiens)		3 / 3ARG A  66
HIS A  62
ARG A  91
None
1.18A18.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DWD_D_GLYD713_0
(DEOXYNUCLEOSIDE
TRIPHOSPHATE
TRIPHOSPHOHYDROLASE
SAMHD1)		2cof PROTEIN KIAA1914
(Homo
sapiens)		3 / 3ARG A  30
HIS A  35
ARG A  42
None
1.17A11.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DWD_D_GLYD713_0
(DEOXYNUCLEOSIDE
TRIPHOSPHATE
TRIPHOSPHOHYDROLASE
SAMHD1)		2vif SUPPRESSOR OF
CYTOKINE SIGNALLING
6
(Homo
sapiens)		3 / 3ARG A 432
HIS A 430
ARG A 409
None
1.06A14.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DWD_D_GLYD713_0
(DEOXYNUCLEOSIDE
TRIPHOSPHATE
TRIPHOSPHOHYDROLASE
SAMHD1)		3gd7 FUSION COMPLEX OF
CYSTIC FIBROSIS
TRANSMEMBRANE
CONDUCTANCE
REGULATOR, RESIDUES
1193-1427 AND
MALTOSE/MALTODEXTRIN
IMPORT ATP-BINDING
PROTEIN MALK,
RESIDUES 219-371
(Escherichia
coli;
Homo
sapiens)		3 / 3ARG A1560
HIS A1575
ARG A1573
None
1.08A21.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DWD_D_GLYD713_0
(DEOXYNUCLEOSIDE
TRIPHOSPHATE
TRIPHOSPHOHYDROLASE
SAMHD1)		3ifq PLAKOGLOBIN
(Homo
sapiens)		3 / 3ARG A 506
HIS A 568
ARG A 572
None
1.09A19.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DWD_D_GLYD713_0
(DEOXYNUCLEOSIDE
TRIPHOSPHATE
TRIPHOSPHOHYDROLASE
SAMHD1)		3kul EPHRIN TYPE-A
RECEPTOR 8
(Homo
sapiens)		3 / 3ARG A 882
HIS A 876
ARG A 856
None
1.19A21.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DWD_D_GLYD713_0
(DEOXYNUCLEOSIDE
TRIPHOSPHATE
TRIPHOSPHOHYDROLASE
SAMHD1)		3sxs CYTOPLASMIC
TYROSINE-PROTEIN
KINASE BMX
(Homo
sapiens)		3 / 3ARG A 656
HIS A 650
ARG A 630
None
1.17A21.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DWD_D_GLYD713_0
(DEOXYNUCLEOSIDE
TRIPHOSPHATE
TRIPHOSPHOHYDROLASE
SAMHD1)		4fdd RNA-BINDING PROTEIN
FUS
(Homo
sapiens)		3 / 3ARG B 518
HIS B 517
ARG B 521
None
1.09A5.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DWD_D_GLYD713_0
(DEOXYNUCLEOSIDE
TRIPHOSPHATE
TRIPHOSPHOHYDROLASE
SAMHD1)		4fq3 FUSION (INVOLVED IN
T(12
16) IN MALIGNANT
LIPOSARCOMA)
(Homo
sapiens)		3 / 3ARG B 518
HIS B 517
ARG B 521
None
1.07A5.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DWD_D_GLYD713_0
(DEOXYNUCLEOSIDE
TRIPHOSPHATE
TRIPHOSPHOHYDROLASE
SAMHD1)		4n9j SERINE/THREONINE-PRO
TEIN KINASE PLK4
(Homo
sapiens)		3 / 3ARG A 697
HIS A 597
ARG A 598
None
0.93A19.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DWD_D_GLYD713_0
(DEOXYNUCLEOSIDE
TRIPHOSPHATE
TRIPHOSPHOHYDROLASE
SAMHD1)		4o3m BLOOM SYNDROME
PROTEIN
(Homo
sapiens)		3 / 3ARG A 859
HIS A 860
ARG A1038
EDO  A1304 (-3.6A)
None
None
1.08A22.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DWD_D_GLYD713_0
(DEOXYNUCLEOSIDE
TRIPHOSPHATE
TRIPHOSPHOHYDROLASE
SAMHD1)		4z6g MICROTUBULE-ACTIN
CROSS-LINKING FACTOR
1, ISOFORMS 1/2/3/5
(Homo
sapiens)		3 / 3ARG A 202
HIS A 201
ARG A 356
None
0.80A20.65
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
6DWD_D_GLYD713_0
(DEOXYNUCLEOSIDE
TRIPHOSPHATE
TRIPHOSPHOHYDROLASE
SAMHD1)		4zwe DEOXYNUCLEOSIDE
TRIPHOSPHATE
TRIPHOSPHOHYDROLASE
SAMHD1
(Homo
sapiens)		3 / 3ARG A 305
HIS A 517
ARG A 531
None
0.67A99.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DWD_D_GLYD713_0
(DEOXYNUCLEOSIDE
TRIPHOSPHATE
TRIPHOSPHOHYDROLASE
SAMHD1)		5lux HOMEOBOX PROTEIN
CDX-1
(Homo
sapiens)		3 / 3ARG K 177
HIS K 174
ARG K 205
None
1.00A8.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DWD_D_GLYD713_0
(DEOXYNUCLEOSIDE
TRIPHOSPHATE
TRIPHOSPHOHYDROLASE
SAMHD1)		5mr4 GDNF FAMILY RECEPTOR
ALPHA-2
(Homo
sapiens)		3 / 3ARG C 198
HIS C 201
ARG C 205
None
1.14Aundetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DWD_D_GLYD713_0
(DEOXYNUCLEOSIDE
TRIPHOSPHATE
TRIPHOSPHOHYDROLASE
SAMHD1)		5muf SERINE/THREONINE-PRO
TEIN PHOSPHATASE
PGAM5, MITOCHONDRIAL
(Homo
sapiens)		3 / 3ARG A 273
HIS A  99
ARG A 265
None
0.86A17.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DWD_D_GLYD713_0
(DEOXYNUCLEOSIDE
TRIPHOSPHATE
TRIPHOSPHOHYDROLASE
SAMHD1)		5vm9 PROTEIN ARGONAUTE-3
(Homo
sapiens)		3 / 3ARG A 711
HIS A 712
ARG A 715
 A  B   9 ( 4.4A)
None
A  B   7 ( 3.4A)
1.18A21.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DWD_D_GLYD713_0
(DEOXYNUCLEOSIDE
TRIPHOSPHATE
TRIPHOSPHOHYDROLASE
SAMHD1)		5wg6 HISTONE-LYSINE
N-METHYLTRANSFERASE
EZH2,POLYCOMB
PROTEIN SUZ12
(E.C.2.1.1.43)
CHIMERA
(Homo
sapiens)		3 / 3ARG A 594
HIS A 593
ARG A 608
None
1.19Aundetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DWD_D_GLYD713_0
(DEOXYNUCLEOSIDE
TRIPHOSPHATE
TRIPHOSPHOHYDROLASE
SAMHD1)		5yvi RNA-BINDING PROTEIN
FUS
(Homo
sapiens)		3 / 3ARG B 518
HIS B 517
ARG B 521
None
0.92Aundetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DWJ_B_GLYB710_0
(DEOXYNUCLEOSIDE
TRIPHOSPHATE
TRIPHOSPHOHYDROLASE
SAMHD1)		1q33 ADP-RIBOSE
PYROPHOSPHATASE
(Homo
sapiens)		4 / 5ARG A  66
GLY A 152
ASN A 149
ASP A 276
None
0.95A19.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DWJ_B_GLYB710_0
(DEOXYNUCLEOSIDE
TRIPHOSPHATE
TRIPHOSPHOHYDROLASE
SAMHD1)		1x9n DNA LIGASE I
(Homo
sapiens)		4 / 5ARG A 449
ARG A 444
GLY A 769
ASP A 378
None
1.34A21.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DWJ_B_GLYB710_0
(DEOXYNUCLEOSIDE
TRIPHOSPHATE
TRIPHOSPHOHYDROLASE
SAMHD1)		2gdz NAD+-DEPENDENT
15-HYDROXYPROSTAGLAN
DIN DEHYDROGENASE
(Homo
sapiens)		4 / 5ARG A  19
GLY A  42
ASN A  38
ASP A  36
None
None
None
NAD  A 300 (-2.8A)
1.23A21.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DWJ_B_GLYB710_0
(DEOXYNUCLEOSIDE
TRIPHOSPHATE
TRIPHOSPHOHYDROLASE
SAMHD1)		2vxo GMP SYNTHASE
[GLUTAMINE-HYDROLYZI
NG]
(Homo
sapiens)		4 / 5ARG A 589
GLY A 273
ASN A 272
ASP A 271
None
0.71A23.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DWJ_B_GLYB710_0
(DEOXYNUCLEOSIDE
TRIPHOSPHATE
TRIPHOSPHOHYDROLASE
SAMHD1)		3nxp PRETHROMBIN-1
(Homo
sapiens)		4 / 5ARG A 633
GLY A 228
ASN A 221
ASP A 225
None
1.32A22.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DWJ_B_GLYB710_0
(DEOXYNUCLEOSIDE
TRIPHOSPHATE
TRIPHOSPHOHYDROLASE
SAMHD1)		3o2q SYMPLEKIN
(Homo
sapiens)		4 / 5ARG A 180
GLY A 178
ASN A 176
ASP A 177
None
1.40A22.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DWJ_B_GLYB710_0
(DEOXYNUCLEOSIDE
TRIPHOSPHATE
TRIPHOSPHOHYDROLASE
SAMHD1)		4chb KELCH-LIKE PROTEIN 2
(Homo
sapiens)		4 / 5ARG A 345
ARG A 343
GLY A 363
ASN A 362
None
SO4  A1596 (-3.0A)
None
SO4  A1596 ( 3.9A)
1.34A19.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DWJ_B_GLYB710_0
(DEOXYNUCLEOSIDE
TRIPHOSPHATE
TRIPHOSPHOHYDROLASE
SAMHD1)		5h9m E3 UBIQUITIN-PROTEIN
LIGASE SIAH2
(Homo
sapiens)		4 / 5ARG A 272
ARG A 273
GLY A 269
ASN A 268
None
1.29A15.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DWJ_B_GLYB710_0
(DEOXYNUCLEOSIDE
TRIPHOSPHATE
TRIPHOSPHOHYDROLASE
SAMHD1)		5la7 HEPARANASE
(Homo
sapiens)		4 / 5ARG A  93
GLY A 223
ASN A 224
ASP A 267
6S6  A 613 ( 4.9A)
None
6S6  A 613 (-2.9A)
None
1.35A19.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DWJ_B_GLYB710_0
(DEOXYNUCLEOSIDE
TRIPHOSPHATE
TRIPHOSPHOHYDROLASE
SAMHD1)		5ms3 KALLIKREIN-8
(Homo
sapiens)		4 / 5ARG A 233
GLY A 179
ASN A 230
ASP A 178
None
1.27Aundetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6MN8_A_GLYA607_0
(UNCHARACTERIZED
PROTEIN)		1now BETA-HEXOSAMINIDASE
BETA CHAIN
(Homo
sapiens)		4 / 4GLU A 288
ASP A 208
ARG A 211
TRP A 489
None
None
IFG  A 557 (-2.8A)
IFG  A 557 (-3.6A)
1.14A20.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6MN8_A_GLYA607_0
(UNCHARACTERIZED
PROTEIN)		2gjx BETA-HEXOSAMINIDASE
ALPHA CHAIN
(Homo
sapiens)		4 / 4GLU A 256
ASP A 175
ARG A 178
TRP A 460
None
None
None
SO4  A 708 (-3.9A)
1.15A21.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6MN8_A_GLYA607_0
(UNCHARACTERIZED
PROTEIN)		2gk1 BETA-HEXOSAMINIDASE
SUBUNIT ALPHA
(Homo
sapiens)		4 / 4GLU I 256
ASP I 175
ARG I 178
TRP I 460
None
None
NGT  A  21 (-2.3A)
NGT  A  21 (-3.7A)
1.11A22.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6MN8_A_GLYA607_0
(UNCHARACTERIZED
PROTEIN)		2gk1 BETA-HEXOSAMINIDASE
SUBUNIT BETA CHAIN B
BETA-HEXOSAMINIDASE
SUBUNIT BETA CHAIN A
(Homo
sapiens;
Homo
sapiens)		4 / 4GLU M 288
ASP M 208
ARG M 211
TRP N 489
None
1.10A16.54